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https://www.readbyqxmd.com/read/29245331/when-omeprazole-met-with-asymptomatic-clostridium-difficile-colonization-in-a-postoperative-colon-cancer-patient-a-case-report
#1
Boyu Li, Huachong Ma, Zhenjun Wang, Lihong Liu
RATIONALE: Clostridium difficile infection (CDI) is a symptomatic infection due to the spore-forming bacterium, C. difficile. Asymptomatic C. difficile colonization is the stage in absence of symptoms, with a prevalence of 1.4% to 21% on hospital admission. Proton-pump inhibitors (PPIs) was implicated as a novel potential contributor to CDI. PPIs injection could make asymptomatic C. difficile colonization progress to C. difficile associated diarrhea (CDAD). PATIENT CONCERNS: A postoperative colon cancer patient, who had been taking omeprazole for 4 years after operation, got asymptomatic C...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29207702/nagging-presence-of-clostridium-difficile-associated-diarrhoea-in-north-india
#2
Rama Chaudhry, Nidhi Sharma, Nitin Gupta, Kamla Kant, Tej Bahadur, Trupti M Shende, Lalit Kumar, Sushil K Kabra
Introduction: Clostridium Difficile Associated Diarrhoea (CDAD) is a significant cause of morbidity in hospitalised patients worldwide. The data on clinical epidemiology of this disease in Indian subcontinent is scarce. Aim: To evaluate the risk factors and clinical course of patients with CDAD. Materials and Methods: A cross-sectional study was planned at our tertiary care centre, All India Institute of Medical Sciences, whereby, all patients who had nosocomial diarrhea between 2010 and 2014 were included in the study...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29195778/epidemiology-and-risk-factors-for-clostridium-difficile-associated-diarrhea-in-adult-inpatients-in-a-university-hospital-in-china
#3
Chenjie Tang, Yang Li, Chengcheng Liu, Pengfei Sun, Xu Huang, Wenying Xia, Huimin Qian, Lunbiao Cui, Genyan Liu
BACKGROUND: Clostridium difficile-associated diarrhea (CDAD) is an important disease with rising incidence and mortality in western countries. However, studies about CDAD in China are limited. The aims of this study are to investigate the epidemiology and risk factors of CDAD in a university hospital located in Eastern China. METHODS: Diarrhea samples of all adult inpatients were collected for C difficile culture prospectively from August 2013-April 2014. Suspected colonies were identified by biochemical identification cards...
November 28, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/29170868/levofloxacin-for-febrile-neutropenia-prophylaxis-in-acute-myeloid-leukemia-patients-associated-with-reduction-in-hospital-admissions
#4
Samantha S F Lee, Adrienne E Fulford, Maureen A Quinn, Jamie Seabrook, Irina Rajakumar
PURPOSE: The purpose of this study is to evaluate the efficacy and safety of prophylactic oral levofloxacin in acute myeloid leukemia (AML) patients after receiving consolidation chemotherapy to prevent febrile neutropenia. METHODS: We conducted a retrospective chart review of 50 AML patients who were prescribed levofloxacin and 50 AML patients who were not prescribed levofloxacin post-consolidation chemotherapy between June 2006 and August 2013 at a tertiary academic medical center...
November 23, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29164044/characterization-of-clostridium-difficile-strains-isolated-from-patients-with-c-difficile-associated-disease-in-korea
#5
Seung-Hak Cho, Jung-Whan Chon, Kun-Ho Seo, Young Kwon Kim, Jung-Beom Kim, Young-Seok Bak, Woon-Won Jung, Cheorl-Ho Kim, Jong Tae Choi
Objectives: Studies on Clostridium difficile are rare in Korea. We investigated the epidemiological characteristics of C. difficile isolates from patients with C. difficile-associated disease (CDAD) in Korea. Methods: Multiplex polymerase chain reaction was performed to detect the presence of tcdA and tcdB toxin genes. Antimicrobial susceptibility test was carried out by the disk-dilution method. C. difficile strains were subtyped by automated repetitive-element palindromic PCR (rep-PCR)...
October 2017: Osong Public Health and Research Perspectives
https://www.readbyqxmd.com/read/29118940/frequency-of-antibiotic-associated-diarrhea-caused-by-clostridium-difficile-among-hospitalized-patients-in-intensive-care-unit-kerman-iran
#6
Ebrahim Rezazadeh Zarandi, Shahla Mansouri, Nouzar Nakhaee, Farhad Sarafzadeh, Zahra Iranmanesh, Mohammad Moradi
Aim: This study evaluated the frequency of C. difficile and CDAD in the ICU of Shahid Bahonhar Hospital, Kerman, Iran. Background: Clostridium difficile (C. difficile) is the most important antibiotic associated diarrhea agent in intensive care unit (ICU) patients. Based on its toxin producing ability, C .difficile is divided to toxigenic and non-toxigenic strains. Methods: A total of 233 diarrheal samples were collected from ICU patients...
2017: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/29044643/fidaxomicin-versus-vancomycin-as-a-first-line-treatment-for-clostridium-difficile-associated-diarrhea-cdad-in-specific-patient-populations-a-pharmacoeconomic-evaluation
#7
Kelly R Reveles, Jennifer L Backo, Frank A Corvino, Marko Zivkovic, Kelly C Broderick
OBJECTIVES: The reduction in recurrent Clostridium difficile-associated diarrhea (CDAD) with fidaxomicin therapy may reduce hospital readmissions and lead to lower overall CDAD costs. However, studies assessing the cost-effectiveness of fidaxomicin as first-line therapy from the United States (US) hospital perspective are lacking. This study evaluated the costs associated with utilizing fidaxomicin or vancomycin as a first-line therapy for CDAD in specific patient populations from a US hospital perspective...
October 17, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28991144/colon-sparing-surgery-for-clostridium-difficile
#8
David N Naumann, Aneel Bhangu, Douglas M Bowley
There has been recent evidence from a large multi-center study sponsored by the Eastern Association for the Surgery of Trauma that colon-sparing surgery reduces mortality for patients with severe Clostridium difficile associated disease (CDAD) when compared to total colectomy. Amoebic colitis shares many pathologic and clinical features to CDAD, such as worsening diarrhoea, patchy colonic ulceration and necrosis, toxic megacolon, pseudomembranous colitis, perforation, and death. However, published research regarding amoebic colitis is sparse...
October 4, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28966486/use-of-culture-and-elisa-based-toxin-assay-for-detecting-clostridium-difficile-a-neglected-pathogen-a-single-center-study-from-a-tertiary-care-setting
#9
Sujata Lall, Gita Nataraj, Preeti Mehta
INTRODUCTION: Clostridium difficile is a Gram-positive spore-bearing anaerobic bacillus increasingly associated with both community- and hospital-acquired colitis and diarrhea. It is the most common identifiable bacterial cause of healthcare-associated diarrhea associated with antibiotic use and one of the most common anaerobic infections. The diagnosis of C. difficile infection includes detection of toxin A/B in stool specimens by direct enzyme immunoassay, culture of pathogen from the stool specimens using a selective agar Cycloserine-Cefoxitin fructose agar (CCFA), tissue culture assay, and detection of glutamate dehydrogenase an enzyme produced by C...
October 2017: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/28827811/long-term-taxonomic-and-functional-divergence-from-donor-bacterial-strains-following-fecal-microbiota-transplantation-in-immunocompromised-patients
#10
Eli L Moss, Shannon B Falconer, Ekaterina Tkachenko, Mingjie Wang, Hannah Systrom, Jasmin Mahabamunuge, David A Relman, Elizabeth L Hohmann, Ami S Bhatt
Immunocompromised individuals are at high risk of developing Clostridium difficile-associated disease (CDAD). Fecal microbiota transplantation (FMT) is a highly effective therapy for refractory or recurrent CDAD and, despite safety concerns, has recently been offered to immunocompromised patients. We investigated the genomics of bacterial composition following FMT in immunocompromised patients over a 1-year period. Metagenomic, strain and gene-level bacterial dynamics were characterized in two CDAD-affected hematopoietic stem cell (HCT) recipients following FMT...
2017: PloS One
https://www.readbyqxmd.com/read/28814204/faecal-microbiota-transplantation-for-em-clostridium-difficile-em-associated-diarrhoea-a-systematic-review-of-randomised-controlled-trials
#11
REVIEW
Paul Moayyedi, Yuhong Yuan, Harith Baharith, Alexander C Ford
OBJECTIVES: Faecal microbiota transplantation (FMT) has emerged as a useful approach for treating Clostridium difficile-associated diarrhoea (CDAD). Randomised controlled trials (RCTs) have recently evaluated its effectiveness, but systematic reviews have focused on evidence from case series. We therefore conducted a systematic review and meta-analysis of RCTs evaluating the effectiveness of FMT for treating CDAD. STUDY DESIGN: We included RCTs that primarily recruited adults with CDAD and compared the effectiveness of FMT with that of placebo, antibiotic therapy, or autologous stool transplantation, or compared different preparations or modes of delivery of FMT...
August 21, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28774865/shifts-in-antimicrobial-consumption-and-infection-rates-before-and-during-a-piperacillin-tazobactam-shortage
#12
S Travis King, Katie E Barber, Jason J Parham, Kayla R Stover
OBJECTIVES: Anti-infective shortages represent a growing threat to optimum management of infected patients and alter the institutional selective pressure against hospital-acquired infections (HAIs). The objective of this analysis was to assess the impact of a shortage of piperacillin/tazobactam (TZP) on overall antibacterial use and HAI rates at an academic institution. METHODS: Antimicrobial use and infection data were extracted from TheraDoc Clinical Surveillance Software (Premier, Inc...
December 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28764868/modeling-new-immunoregulatory-therapeutics-as-antimicrobial-alternatives-for-treating-clostridium-difficile-infection
#13
Andrew Leber, Raquel Hontecillas, Vida Abedi, Nuria Tubau-Juni, Victoria Zoccoli-Rodriguez, Caroline Stewart, Josep Bassaganya-Riera
The current treatment paradigm in Clostridium difficile infection is the administration of antibiotics contributing to the high rates of recurrent infections. Recent alternative strategies, such as fecal microbiome transplantation and anti-toxin antibodies, have shown similar efficacy in the treatment of C. difficile associated disease (CDAD). However, barriers exist for either treatment or other novel treatments to displace antibiotics as the standard of care. To aid in the comparison of these and future treatments in CDAD, we developed an in silico pipeline to predict clinical efficacy with nonclinical results...
May 2017: Artificial Intelligence in Medicine
https://www.readbyqxmd.com/read/28652125/probiotic-containing-lactobacillus-casei-lactobacillus-bulgaricus-and-streptococcus-thermophiles-actimel-for-the-prevention-of-clostridium-difficile-associated-diarrhoea-in-the-elderly-with-proximal-femur-fractures
#14
Ravi Mallina, J Craik, N Briffa, Viren Ahluwalia, J Clarke, A G Cobb
The incidence of Clostridium difficile associated diarrhoea (CDAD) is greater in elderly patients. Probiotics may have a beneficial effect in the prevention of CDAD. However, their effect in elderly orthopaedic patients has not been previously reported. Between April 2013 and April 2014, 105 patients admitted with femoral neck fractures, and who required 3days of antibiotics for infection of any cause, were prescribed the probiotic ACTIMEL until 3days after the last antibiotic dose. The incidence of CDAD was compared with historical controls (April 2011-April 2012)...
June 23, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28582620/observation-of-enhanced-chiral-asymmetries-in-the-inner-shell-photoionization-of-uniaxially-oriented-methyloxirane-enantiomers
#15
Maurice Tia, Martin Pitzer, Gregor Kastirke, Janine Gatzke, Hong-Keun Kim, Florian Trinter, Jonas Rist, Alexander Hartung, Daniel Trabert, Juliane Siebert, Kevin Henrichs, Jasper Becht, Stefan Zeller, Helena Gassert, Florian Wiegandt, Robert Wallauer, Andreas Kuhlins, Carl Schober, Tobias Bauer, Natascha Wechselberger, Phillip Burzynski, Jonathan Neff, Miriam Weller, Daniel Metz, Max Kircher, Markus Waitz, Joshua B Williams, Lothar Ph H Schmidt, Anne D Müller, André Knie, Andreas Hans, Ltaief Ben Ltaief, Arno Ehresmann, Robert Berger, Hironobu Fukuzawa, Kiyoshi Ueda, Horst Schmidt-Böcking, Reinhard Dörner, Till Jahnke, Philipp V Demekhin, Markus Schöffler
Most large molecules are chiral in their structure: they exist as two enantiomers, which are mirror images of each other. Whereas the rovibronic sublevels of two enantiomers are almost identical (neglecting a minuscular effect of the weak interaction), it turns out that the photoelectric effect is sensitive to the absolute configuration of the ionized enantiomer. Indeed, photoionization of randomly oriented enantiomers by left or right circularly polarized light results in a slightly different electron flux parallel or antiparallel with respect to the photon propagation direction-an effect termed photoelectron circular dichroism (PECD)...
June 8, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28575523/safety-and-pharmacokinetic-study-of-fidaxomicin-in-children-with-clostridium-difficile-associated-diarrhea-a-phase-2a-multicenter-clinical-trial
#16
Molly A O'Gorman, Marian G Michaels, Sheldon L Kaplan, Anthony Otley, Larry K Kociolek, Edward J Hoffenberg, Kwang Sik Kim, Sharon Nachman, Marian D Pfefferkorn, Timothy Sentongo, Janice E Sullivan, Pamela Sears
Background.: Fidaxomicin is an approved therapy for Clostridium difficile-associated diarrhea (CDAD) in adults. The safety of fidaxomicin in children has not been reported. Methods.: In this study (ClinicalTrials.gov identifier NCT01591863), pediatric patients with CDAD received twice-daily oral fidaxomicin at a dose of 16 mg/kg per day (up to 200 mg) for 10 days in an open-label study. Plasma and fecal samples were collected for pharmacokinetic assessments. The primary outcome measure was safety, which was assessed by adverse-event (AE), laboratory, and physical examination/vital-sign monitoring...
May 31, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28426557/loop-ileostomy-versus-total-colectomy-as-surgical-treatment-for-clostridium-difficile-associated-disease-an-eastern-association-for-the-surgery-of-trauma-multicenter-trial
#17
MULTICENTER STUDY
Paula Ferrada, Rachael Callcut, Martin D Zielinski, Brandon Bruns, Daniel Dante Yeh, Tanya L Zakrison, Jonathan P Meizoso, Babak Sarani, Richard D Catalano, Peter Kim, Valerie Plant, Amelia Pasley, Linda A Dultz, Asad J Choudhry, Elliott R Haut
OBJECTIVES: The mortality of patients with Clostridium difficile-associated disease (CDAD) requiring surgery continues to be very high. Loop ileostomy (LI) was introduced as an alternative procedure to total colectomy (TC) for CDAD by a single-center study. To date, no reproducible results have been published. The objective of this study was to compare these two procedures in a multicentric approach to help the surgeon decide what procedure is best suited for the patient in need. METHODS: This was a retrospective multicenter study conducted under the sponsorship of the Eastern Association for the Surgery of Trauma...
July 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28366569/development-of-a-dose-assay-for-a-clostridium-difficile-vaccine-using-a-tandem-ion-exchange-high-performance-liquid-chromatography-method
#18
Feng Wang, Sha Ha, Richard R Rustandi
Clostridium difficile is a gram-positive intestine bacterium that causes a severe diarrhea and could eventually be lethal. The main virulence factor is related to the release of two major exotoxins, toxin A (TcdA) and toxin B (TcdB). Recent C. difficile-associated disease (CDAD) outbreaks have been caused by hypervirulent strains which secrete an additional binary toxin (CDTa/CDTb). Vaccination against these toxins is considered the best way to combat the CDAD. Recently, a novel tetravalent C. difficile vaccine candidate containing all four toxins produced from a baculovirus expression system has been developed...
May 19, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28336757/development-of-a-bedside-scoring-system-for-predicting-a-first-recurrence-of-clostridium-difficile-associated-diarrhea
#19
Velliyur Viswesh, Ana L Hincapie, Marie Yu, Linda Khatchatourian, Michael A Nowak
PURPOSE: A scoring system for identifying patients at high or low risk for recurrent Clostridium difficile-associated diarrhea (CDAD) is described. METHODS: A retrospective cohort study was performed using data on adults with CDAD admitted to a 3-hospital system from 2009 to 2014. The primary endpoint was the rate of recurrent CDAD within 60 days of clinical cure of CDAD. Risk factors for CDAD recurrence were identified, and a risk prediction tool was developed using multivariate logistic regression...
April 1, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28265914/-probiotics-is-there-evidence-for-use-against-antibiotic-induced-diarrhea-cdad-and-travellers-diarrhea
#20
REVIEW
Johannes Bogner
No abstract text is available yet for this article.
March 2017: MMW Fortschritte der Medizin
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