Erfan Mohammadi, Fatemeh Sadoughi, Simin Younesi, Ansar Karimian, Zatollah Asemi, Nader Farsad-Akhtar, Fahime Jahanbakhshi, Hamidreza Jamilian, Bahman Yousefi
This review summarizes and addresses non-coding RNAs (rRNA, tRNA, Vault and Y RNA, snRNA, and miRNA) cytoplasmic decay pathways, the molecules, enzymes, and modifications such as uridylation, which play vital roles in the degradation processes in various eukaryotic organisms. Plus, SIRT1's role in fundamental cellular processes, including autophagy, DNA repair, DNA damage response (DDR), and the molecular mechanisms, is explored. Further, the HuR (an RNA-binding protein) impact on the expression of genes following DNA damage, and the pathways that regulate HuR function, which is through phosphorylation by Chk1/Cdk1 and Chk2, are specified...
July 2021: DNA Repair