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https://www.readbyqxmd.com/read/28500775/vaccines-against-malaria-still-a-long-way-to-go
#1
REVIEW
Kai Matuschewski
Several species of Plasmodium cause a broad spectrum of human disease that range from nausea and fever to severe anemia, cerebral malaria, and multi-organ failure. In malaria-endemic countries continuous exposure to Plasmodium sporozoite inoculations and subsequent blood infections elicit only partial and short-lived immunity, which gradually develops over many years of parasite exposure and multiple clinical episodes. The ambitious goal of malaria vaccinology over the past 70 years has been to develop an immunization strategy that mounts protection superior to naturally acquired immunity...
May 13, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28493819/the-choice-of-freely-preferred-cadence-by-trained-nonprofessional-cyclists-may-not-be-characterized-by-mechanical-efficiency
#2
Yitzhak Weinstein, Ron Mor-Unikowski, Shachar Nice, Shraga Hocherman, Omri Inbar
BACKGROUND: Most cycling studies involve professional cyclists. Because training may affect riding style, it is of interest to determine the physiological basis for the personal choice of cycling cadence in nonprofessional cyclists. METHODS: Eleven nonprofessional (5.2±1.7-year-riding experience) male road cyclists, aged 35.0±11.0 years, underwent four separate laboratory test sessions. The first two sessions included habituation, anthropometry, V˙O2max,$\dot V{{\text{O}}_{\text{2}}}{\text{max}},$ and lactate threshold (LaTH) measurements...
May 11, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28463097/road-traffic-injury-in-lagos-nigeria-assessing-prehospital-care
#3
Nasiru A Ibrahim, Abdul Wahab O Ajani, Ibrahim A Mustafa, Rufai A Balogun, Mobolaji A Oludara, Olufemi E Idowu, Babatunde A Solagberu
Introduction Injuries are the third most important cause of overall deaths globally with one-quarter resulting from road traffic crashes. Majority of these deaths occur before arrival in the hospital and can be reduced with prompt and efficient prehospital care. The aim of this study was to highlight the burden of road traffic injury (RTI) in Lagos, Nigeria and assess the effectiveness of prehospital care, especially the role of Lagos State Ambulance Service (LASAMBUS) in providing initial care and transportation of the injured to the hospital...
May 2, 2017: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/28455199/upper-body-compression-garment-physiological-effects-while-cycling-in-a-hot-environment
#4
Iker Leoz-Abaurrea, Roberto Aguado-Jiménez
OBJECTIVE: The purpose of the present study was to investigate the effects of an upper body compression garment (UBCG) on physiologic and perceptual responses while cycling in a hot environment. METHODS: Twenty recreational road cyclists were pair-matched for age, anthropometric data, and fitness level (V̇O2max) and randomly assigned to a control (CON) group (n=10) of cyclists who wore a conventional t-shirt or to a group (n=10) of cyclists who wore UBCG. Test session consisted of cycling at a fixed load (~50% V̇O2max) for 30 minutes at an ambient temperature of ~40ºC (39...
April 25, 2017: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/28445875/double-incision-approach-and-early-rehabilitation-in-a-complicated-bicondylar-br-tibial-plateau-fracture-a-case-report-br-br
#5
Saverio Affatato, Maurizio Montalti, Claudio Masetti, Federico Giardina, Alessandra Sudanese
OBJECTIVE: The main goal of this case was to report the treatment of bicondylar fractures of the tibial plateau and the restoration of the metaphyseo-diaphyseal dissociation. CLINICAL PRESENTATION AND INTERVENTION: A 54-year old man who was cycling had a road accident that caused a closed fracture of the right tibial plateau and proximal fibula diagnosed by x-rays. Patient had surgical procedure and was immobilized with a long-leg splint for 4 weeks. After immobilization, aggressive rehabilitation was done...
April 26, 2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/28445540/individuals-with-severely-impaired-vision-can-learn-useful-orientation-and-mobility-skills-in-virtual-streets-and-can-use-them-to-improve-real-street-safety
#6
Ellen Lambert Bowman, Lei Liu
Virtual reality has great potential in training road safety skills to individuals with low vision but the feasibility of such training has not been demonstrated. We tested the hypotheses that low vision individuals could learn useful skills in virtual streets and could apply them to improve real street safety. Twelve participants, whose vision was too poor to use the pedestrian signals were taught by a certified orientation and mobility specialist to determine the safest time to cross the street using the visual and auditory signals made by the start of previously stopped cars at a traffic-light controlled street intersection...
2017: PloS One
https://www.readbyqxmd.com/read/28445398/consensus-based-cooperative-control-based-on-pollution-sensing-and-traffic-information-for-urban-traffic-networks
#7
Antonio Artuñedo, Raúl M Del Toro, Rodolfo E Haber
Nowadays many studies are being conducted to develop solutions for improving the performance of urban traffic networks. One of the main challenges is the necessary cooperation among different entities such as vehicles or infrastructure systems and how to exploit the information available through networks of sensors deployed as infrastructures for smart cities. In this work an algorithm for cooperative control of urban subsystems is proposed to provide a solution for mobility problems in cities. The interconnected traffic lights controller (TLC) network adapts traffic lights cycles, based on traffic and air pollution sensory information, in order to improve the performance of urban traffic networks...
April 26, 2017: Sensors
https://www.readbyqxmd.com/read/28436731/fatal-and-serious-collisions-involving-pedal-cyclists-and-trucks-in-london-between-2007-and-2011
#8
Rachel Talbot, Steve Reed, Nicola Christie, Jo Barnes, Pete Thomas
OBJECTIVE: Increased numbers of people riding pedal cycles have led to a greater focus on pedal cycle safety. The aim of this article is to explore factors that are associated with fatal and a small number of serious-injury pedal cyclist crashes involving trucks that occurred in London between 2007 and 2011. METHODS: Data were collected from police collision files for 53 crashes, 27 of which involved a truck (≥3.5 tonnes) and a pedal cycle. A systematic case review approach was used to identify the infrastructure, vehicle road user, and management factors that contributed to these crashes and injuries and how these factors interacted...
February 8, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28436392/the-dna-damage-response-in-neurons-die-by-apoptosis-or-survive-in-a-senescence-like-state
#9
Edward Fielder, Thomas von Zglinicki, Diana Jurk
Neurons are exposed to high levels of DNA damage from both physiological and pathological sources. Neurons are post-mitotic and their loss cannot be easily recovered from; to cope with DNA damage a complex pathway called the DNA damage response (DDR) has evolved. This recognizes the damage, and through kinases such as ataxia-telangiectasia mutated (ATM) recruits and activates downstream factors that mediate either apoptosis or survival. This choice between these opposing outcomes integrates many inputs primarily through a number of key cross-road proteins, including ATM, p53, and p21...
April 18, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28426205/euro-6-unregulated-pollutant-characterization-and-statistical-analysis-of-after-treatment-device-and-driving-condition-impact-on-recent-passenger-car-emissions
#10
Simon Martinet, Yao Liu, Cédric Louis, Patrick Tassel, Pascal Perret, Agnès Chaumond, Michel André
This study aims to measure and analyze unregulated compound emissions for two Euro 6 diesel and gasoline vehicles. The vehicles were tested on a chassis dynamometer under various driving cycles: Artemis driving cycles (urban, road, and motorway), the New European Driving Cycle (NEDC) and the World Harmonized Light-Duty Test Cycle (WLTC) for Europe, and world approval cycles. The emissions of unregulated compounds (such as total particle number (PN) (over 5.6 nm); black carbon (BC); NO2; benzene, toluene, ethylbenzene, and xylene (BTEX); carbonyl compounds; and polycyclic aromatic hydrocarbons (PAHs)) were measured with several online devices, and different samples were collected using cartridges and quartz filters...
April 28, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28388327/biology-of-psorophora-albigenu-under-laboratory-conditions
#11
Jeronimo Alencar, Juliana Pacheco, Júlia Dos Santos Silva, Cecilia Ferreira Mello, Anthony Érico Guimarães
The present study investigates the effect of multiple immersions on Psorophora albigenu eggs and their development cycle under laboratory conditions. Engorged Ps. albigenu specimens were captured in January 2011 around the Transpantaneira Park Road, Mato Grosso, Brazil, using CO2-baited Centers for Disease Control and Prevention light traps. Psorophora albigenu eggs (n = 1274) were subjected to immersion, with a hatching rate between 49% and 73%. The Williams average showed a peak of 29% hatched eggs in the 3rd immersion; after 4-5 immersions, the effect of additional immersions was generally negligible...
March 2017: Journal of the American Mosquito Control Association
https://www.readbyqxmd.com/read/28384490/multiuse-trail-intersection-safety-analysis-a-crowdsourced-data-perspective
#12
Ben Jestico, Trisalyn A Nelson, Jason Potter, Meghan Winters
Real and perceived concerns about cycling safety are a barrier to increased ridership in many cities. Many people prefer to bike on facilities separated from motor vehicles, such as multiuse trails. However, due to underreporting, cities lack data on bike collisions, especially along greenways and multiuse paths. We used a crowdsourced cycling incident dataset (2005-2016) from BikeMaps.org for the Capital Regional District (CRD), BC, Canada. Our goal was to identify design characteristics associated with unsafe intersections between multiuse trails and roads...
April 3, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28368958/a-field-based-cycling-test-to-assess-predictors-of-endurance-performance-and-establishing-training-zones
#13
Dajo Sanders, Richard J Taylor, Tony Myers, Ibrahim Akubat
This study evaluates the relationship between a field-based 8-min time trial (8MTT) and physiological endurance variables assessed with an incremental laboratory test. Secondly, lactate thresholds assessed in the laboratory were compared to estimated functional threshold power (FTP) from the 8MTT. Nineteen well-trained road cyclists (aged 22 ± 2 yr, height 185.9 ± 4.5 cm, weight 72.8 ± 4.6 kg, VO2max 64 ± 4 ml·min·kg) participated. Linear regression revealed that mean 8MTT power output (PO) was strongly to very strongly related to PO at 4 mmol[BULLET OPERATOR]L, PO at initial rise of 1...
March 25, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28365563/pedestrian-inattention-blindness-while-playing-pok%C3%A3-mon-go-as-an-emerging-health-risk-behavior-a-case-report
#14
Stefania Barbieri, Gianna Vettore, Vincenzo Pietrantonio, Rossella Snenghi, Alberto Tredese, Mauro Bergamini, Sara Previato, Armando Stefanati, Rosa Maria Gaudio, Paolo Feltracco
BACKGROUND: Cases of trauma resulting from the use of mobile phones while driving motor vehicles have become quite common in recent years. Road injuries incurred by people playing video games on mobile phones (or other media devices) while walking have also become a cause for concern. Pokémon Go has been the world's most popular game since it was launched in July 2016, with more than 15 million players trying to catch all Pokémon available in the game; however, the case detailed here is the first reported accident in the medical literature caused by a pedestrian distracted by the game while crossing a street...
April 1, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28364017/recording-sympathetic-nerve-activity-in-conscious-humans-and-other-mammals-guidelines-and-the-road-to-standardization
#15
Emma C J Hart, Geoffrey A Head, Jason R Carter, Gunnar Wallin, Clive N May, Shereen M Hamza, John E Hall, Nisha Charkoudian, John W Osborn
Over the past several decades, studies of the sympathetic nervous system in humans, sheep, rabbits, rats and mice have substantially increased mechanistic understanding of cardiovascular function and dysfunction. Recently, interest in sympathetic neural mechanisms contributing to blood pressure control has grown, due in part to the development of devices or surgical procedures, which treat hypertension by manipulating sympathetic outflow. Studies in animal models have provided important insights into physiological and pathophysiological mechanisms, which are not accessible in human studies...
March 31, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28296466/road-accident-fatality-risks-for-vulnerable-versus-protected-road-users-in-northern-ghana
#16
James Damsere-Derry, Gavan Palk, Mark King
Background Road traffic injuries (RTIs) are a serious epidemic which claims more than a million lives across the globe each year. The burden of RTIs is particularly pronounced in Africa and other low and middle income countries. The unfavourable disparity of the burden of road trauma in the world is largely attributable to unsafe vehicles, lack of appropriate road infrastructure and the predominance of vulnerable road users (VRUs) in developing countries. However, little research exists in Northern Ghana to highlight the scale and risk of death among road users...
March 15, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28282865/utilizing-crowdsourced-data-for-studies-of-cycling-and-air-pollution-exposure-a-case-study-using-strava-data
#17
Yeran Sun, Amin Mobasheri
With the development of information and communications technology, user-generated content and crowdsourced data are playing a large role in studies of transport and public health. Recently, Strava, a popular website and mobile app dedicated to tracking athletic activity (cycling and running), began offering a data service called Strava Metro, designed to help transportation researchers and urban planners to improve infrastructure for cyclists and pedestrians. Strava Metro data has the potential to promote studies of cycling and health by indicating where commuting and non-commuting cycling activities are at a large spatial scale (street level and intersection level)...
March 8, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28259828/how-did-the-economic-recession-2008-2010-influence-traffic-fatalities-in-oecd-countries
#18
REVIEW
Fred Wegman, Richard Allsop, Constantinos Antoniou, Ruth Bergel-Hayat, Rune Elvik, Sylvain Lassarre, Daryl Lloyd, Wim Wijnen
This paper presents analyses of how the economic recession that started in 2008 has influenced the number of traffic fatalities in OECD countries. Previous studies of the relationship between economic recessions and changes in the number of traffic fatalities are reviewed. Based on these studies, a causal diagram of the relationship between changes of the business cycle and changes in the number of traffic fatalities is proposed. This causal model is tested empirically by means of multivariate analyses and analyses of accident statistics for Great Britain and Sweden...
May 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28253040/demands-of-world-cup-competitions-in-elite-women-road-cycling
#19
Paolo Menaspà, Marco Sias, Gene Bates, Antonio La Torre
PURPOSE: Describing the demand of recent World Cup (WC) races comparing Top 10 (T10) and non-Top 10 (N-T10) performances using power data. METHODS: Race data were collected in 1-day World Cup races during the 2012-2015 road cycling seasons. Seven female cyclists completed 49 WC races, finishing 25 times in T10 and 24 times N-T10. Peak power (1 s) and Maximal Mean Power (MMP) for durations of 5, 10, 20 and 30 s and 1, 2, 5, 10, 20, 30 and 60 min expressed as power to weight ratio were analysed in T10 and N-T10...
March 2, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28235858/in-vivo-assessment-of-regional-mechanics-post-myocardial-infarction-a-focus-on-the-road-ahead
#20
Eva Romito, Tarek Shazly, Francis G Spinale
Cardiovascular disease, particularly the occurrence of myocardial infarction (MI), remains a leading cause of morbidity and mortality. There is growing recognition that a key factor for post-MI outcomes is adverse remodeling and changes in the regional structure, composition, and mechanical properties of the MI region itself. However, in-vivo assessment of regional mechanics post-MI can be confounded by the species, temporal aspects of MI healing, as well as size, location, and extent of infarction across myocardial wall...
February 23, 2017: Journal of Applied Physiology
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