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https://www.readbyqxmd.com/read/28746232/the-effect-of-topical-thiocolchicoside-in-preventing-and-reducing-the-increase-of-muscle-tone-stiffness-and-soreness-a-real-life-study-on-top-level-road-cyclists-during-stage-competition
#1
Marco Gervasi, Davide Sisti, Piero Benelli, Eneko Fernández-Peña, Cinzia Calcabrini, Marco B L Rocchi, Luigi Lanata, Michela Bagnasco, Andrea Tonti, Stocchi Vilberto, Piero Sestili
In professional road cyclists, the majority of overuse injuries affect the lower limbs and are mostly represented by contractures or muscle shortening, characterized by an increase of tone and stiffness and a variation of elasticity. Treatment and prevention of these specific conditions may include physical, supplementary, and pharmacologic support. The aim of this real-life study was to determine: first, the alterations of tone, stiffness, elasticity, and soreness of rectus femoris (RF) and biceps femoris (BF) in top class cyclists engaged in 3 multistage races, and second, whether any variable in the management of the athletes may affect the prevention and/or reduction of such alterations...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28739377/blood-hemostatic-changes-during-an-ultraendurance-road-cycling-event-in-a-hot-environment
#2
Brian R Kupchak, Josh B Kazman, Jakob L Vingren, Danielle E Levitt, Elaine C Lee, Keith H Williamson, Lawrence E Armstrong, Patricia A Deuster
OBJECTIVE: This study aims to examine blood hemostatic responses to completing a 164-km road cycling event in a hot environment. METHODS: Thirty-seven subjects (28 men and 9 women; 51.8±9.5 [mean±SD] y) completed the ride in 6.6±1.1 hours. Anthropometrics (height, body mass [taken also during morning of the ride], percent body fat [%]) were collected the day before the ride. Blood samples were collected on the morning of the ride (PRE) and immediately after (IP) the subject completed the ride...
July 21, 2017: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/28732320/do-cyclists-make-better-drivers-associations-between-cycling-experience-and-change-detection-in-road-scenes
#3
Vanessa Beanland, Lisa J Hansen
Efficient processing of visual information is crucial to safe driving. Previous research has demonstrated that driving experience strongly affects attentional allocation, with large differences between novice and experienced drivers. Expanding on this, we explored the influence of non-driving experiences on attentional allocation by comparing drivers with and without cycling experience. Based on situation awareness field studies, we predicted cyclist-drivers would demonstrate superior performance. Participants were 42 experienced drivers (17 female, 25 male) aged 30-50 years (M=39...
July 18, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28730920/validity-of-a-device-designed-to-measure-braking-power-in-bicycle-disc-brakes
#4
Matthew C Miller, Philip W Fink, Paul William Macdermid, Blake G Perry, Stephen R Stannard
Real-world cycling performance depends not only on exercise capacities, but also on efficiently traversing the bicycle through the terrain. The aim of this study was to determine if it was possible to quantify the braking done by a cyclist in the field. One cyclist performed 408 braking trials (348 on a flat road; 60 on a flat dirt path) over 5 days on a bicycle fitted with brake torque and angular velocity sensors to measure brake power. Based on Newtonian physics, the sum of brake work, aerodynamic drag and rolling resistance was compared with the change in kinetic energy in each braking event...
July 21, 2017: Sports Biomechanics
https://www.readbyqxmd.com/read/28722536/travel-burden-associated-with-granulocyte-colony-stimulating-factor-administration-in-a-medicare-aged-population-a-geospatial-analysis
#5
J Mark Stephens, Mark Bensink, Charles Bowers, Christopher S Hollenbeak
OBJECTIVE: Prophylaxis with granulocyte colony-stimulating factors (G-CSFs) is recommended for patients receiving myelosuppressive chemotherapy regimens with a high risk of febrile neutropenia (FN). G-CSFs should be administered starting the day after chemotherapy, necessitating return trips to the oncology clinic at the end of each cycle. We examined the travel burden related to prophylactic G-CSF injections after chemotherapy in the United States (US). METHODS: We used 2012-2014 Medicare claims data to identify a national cohort of beneficiaries age 65+ with non-myeloid cancers who received both chemotherapy and prophylactic G-CSFs...
July 19, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28721185/the-smooth-and-bumpy-road-of-trastuzumab-administration-from-intravenous-iv-in-a-hospital-to-subcutaneous-sc-at-home
#6
Waa Tjalma, M T Huizing, K Papadimitriou
Trastuzumab has become standard of care in the treatment of early and metastatic HER2-positive breast cancer. Initially trastuzumab could only be administered intravenously (IV), however since a few years there is also a subcutaneous (SC) formulation. The efficacy and the safety profile of both formulations is the comparable. The administration logistics however have an impact on the patients, the health care professionals (HCPs), the hospital and the government. The preference for the patients (89%) and the HCPs (77%) is in favour of the SC formulation...
March 2017: Facts, Views & Vision in ObGyn
https://www.readbyqxmd.com/read/28710974/predictors-of-recovery-in-cyclists-hospitalised-for-orthopaedic-trauma-following-an-on-road-crash
#7
Ben Beck, Christina L Ekegren, Peter Cameron, Elton R Edwards, Andrew Bucknill, Rodney Judson, Richard Page, Raphael Hau, Mark Stevenson, Belinda J Gabbe
BACKGROUND: As cycling-related injury rates are on the rise, there is a need to understand the long term outcomes of these patients in order to quantify the burden of injury and to inform injury prevention strategies. This study aimed to investigate predictors of return to work and functional recovery in a cohort of cyclists hospitalised for orthopaedic trauma from crashes occurring on-road. METHODS: A retrospective analysis of data from the Victorian Orthopaedic Trauma Outcomes Registry (VOTOR) was conducted for patients who were hospitalised for orthopaedic trauma following a cycling crash that occurred on-road between July 2007 and June 2015...
July 12, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28700517/a-longitudinal-assessment-of-bone-mineral-density-and-body-composition-in-competitive-cyclists
#8
Breanne S Baker, Raoul F Reiser
Competitive cycling has been associated with low bone mineral density (BMD); however, BMD is a multifaceted issue. The purpose of this study was to investigate how age (18-49 years), sex, USA Cycling Category (elite-4) and racing type (road and multiple bikes), influenced body composition across a season in competitive cyclists. February marked the preseason, where 42 participants (22 males, 20 females) completed a health history and cycling questionnaire, four day dietary log and a Dual-energy X-ray absorptiometry (DXA) scan and repeated the measures 180±11 days later...
July 8, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28693547/longitudinal-associations-between-built-environment-characteristics-and-changes-in-active-commuting
#9
Lin Yang, Simon Griffin, Kay-Tee Khaw, Nick Wareham, Jenna Panter
BACKGROUND: Few studies have assessed the predictors of changes in commuting. This study investigated the associations between physical environmental characteristics and changes in active commuting. METHODS: Adults from the population-based European Prospective Investigation into Cancer (EPIC)-Norfolk cohort self-reported commuting patterns in 2000 and 2007. Active commuters were defined as those who reported 'always' or 'usually' walking or cycling to work. Environmental attributes around the home and route were assessed using Geographical Information Systems...
May 17, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28686682/a-road-damage-and-life-cycle-greenhouse-gas-comparison-of-trucking-and-pipeline-water-delivery-systems-for-hydraulically-fractured-oil-and-gas-field-development-in-colorado
#10
Ray C Duthu, Thomas H Bradley
The process of hydraulic fracturing for recovery of oil and natural gas uses large amounts of fresh water and produces a comparable amount of wastewater, much of which is typically transported by truck. Truck transport of water is an expensive and energy-intensive process with significant external costs including roads damages, and pollution. The integrated development plan (IDP) is the industry nomenclature for an integrated oil and gas infrastructure system incorporating pipeline-based transport of water and wastewater, centralized water treatment, and high rates of wastewater recycling...
2017: PloS One
https://www.readbyqxmd.com/read/28669689/effects-of-erythropoietin-on-cycling-performance-of-well-trained-cyclists-a-double-blind-randomised-placebo-controlled-trial
#11
Jules A A C Heuberger, Joris I Rotmans, Pim Gal, Frederik E Stuurman, Juliëtte van 't Westende, Titiaan E Post, Johannes M A Daniels, Matthijs Moerland, Peter L J van Veldhoven, Marieke L de Kam, Herman Ram, Olivier de Hon, Jelle J Posthuma, Jacobus Burggraaf, Adam F Cohen
BACKGROUND: Substances that potentially enhance performance (eg, recombinant human erythropoietin [rHuEPO]) are considered doping and are therefore forbidden in sports; however, the scientific evidence behind doping is frequently weak. We aimed to determine the effects of rHuEPO treatment in well trained cyclists on maximal, submaximal, and race performance and on safety, and to present a model clinical study for doping research on other substances. METHODS: We did this double-blind, randomised, placebo-controlled trial at the Centre for Human Drug Research in Leiden (Netherlands)...
June 29, 2017: Lancet Haematology
https://www.readbyqxmd.com/read/28658846/concomitant-presence-of-carcinoma-of-breast-in-a-patient-with-early-onset-cataract-first-case-report-of-a-potential-association
#12
Shahbaz Habib Faridi, Kaushal Deep Singh, Mehershree Lodhi
A recent nation-wide population based retrospective cohort study from Taiwan in 2014 suggested a propensity of developing breast cancer in young females with early-onset cataract. We report here a case of a young non-obese female who presented to us with a large lump in the right breast with skin nodules and bilateral painless progressive diminution of vision. Patient was diagnosed to be suffering from locally advanced carcinoma of right breast with axillary metastasis (Stage III B) and bilateral early-onset nuclear cataract...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28657804/physiological-profile-of-an-uphill-time-trial-in-elite-cyclists
#13
Ana B Peinado, Nuria Romero-Parra, Miguel A Rojo-Tirado, Rocío Cupeiro, Javier Butragueño, Eliane A Castro, Francisco J Calderón, Pedro J Benito
PURPOSE: While a number of studies have researched road cycling performance, few studies have attempted to investigate the physiological response in field conditions. Therefore, the purpose of this study was to describe the physiological and performance profile of an uphill time-trial frequently used in cycling competitions. METHODS: Fourteen elite road cyclists (mean±SD: age 25±6 years, height 174±4.2 cm, body mass 64.4±6.1 kg and fat mass 7.48±2.82%) performed a graded exercise test until exhaustion to determine maximal parameters...
June 28, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28657135/dna-methylation-mediated-repression-of-mir-766-3p-promotes-cell-proliferation-via-targeting-sf2-expression-in-renal-cell-carcinoma
#14
Chen Chen, Sheng Xue, Jin Zhang, Wei Chen, Dongkui Gong, Jiayi Zheng, Junjie Ma, Wei Xue, Yonghui Chen, Wei Zhai, Junhua Zheng
Aberrant expression of microRNA (miRNA) emerges as an important role in a wide range of human malignances, and further identification as well as validation of the change of these endogenous non-protein-coding transcripts is warranted. Here, we identify a novel epigenetic regulation of miR-766-3p and investigate its biological function as well as clinical significance in renal cell carcinoma (RCC). Bisulfate analysis elucidates that the promoter of miR-766-3p is highly methylated in RCC tissues compared with non-tumorous tissues...
June 28, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28651557/amphibian-and-reptile-road-kills-on-tertiary-roads-in-relation-to-landscape-structure-using-a-citizen-science-approach-with-open-access-land-cover-data
#15
Florian Heigl, Kathrin Horvath, Gregor Laaha, Johann G Zaller
BACKGROUND: Amphibians and reptiles are among the most endangered vertebrate species worldwide. However, little is known how they are affected by road-kills on tertiary roads and whether the surrounding landscape structure can explain road-kill patterns. The aim of our study was to examine the applicability of open-access remote sensing data for a large-scale citizen science approach to describe spatial patterns of road-killed amphibians and reptiles on tertiary roads. Using a citizen science app we monitored road-kills of amphibians and reptiles along 97...
June 26, 2017: BMC Ecology
https://www.readbyqxmd.com/read/28649687/vehicle-emissions-of-short-lived-and-long-lived-climate-forcers-trends-and-tradeoffs
#16
Morgan R Edwards, Magdalena M Klemun, Hyung Chul Kim, Timothy J Wallington, Sandra L Winkler, Michael A Tamor, Jessika E Trancik
Evaluating technology options to mitigate the climate impacts of road transportation can be challenging, particularly when they involve a tradeoff between long-lived emissions (e.g., carbon dioxide) and short-lived emissions (e.g., methane or black carbon). Here we present trends in short- and long-lived emissions for light- and heavy-duty transport globally and in the U.S., EU, and China over the period 2000-2030, and we discuss past and future changes to vehicle technologies to reduce these emissions. We model the tradeoffs between short- and long-lived emission reductions across a range of technology options, life cycle emission intensities, and equivalency metrics...
June 26, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28617345/examining-associations-of-environmental-characteristics-with-recreational-cycling-behaviour-by-street-level-strava-data
#17
Yeran Sun, Yunyan Du, Yu Wang, Liyuan Zhuang
Policymakers pay much attention to effectively increasing frequency of people's cycling in the context of developing sustainable and green cities. Investigating associations of environmental characteristics and cycling behaviour could offer implications for changing urban infrastructure aiming at encouraging active travel. However, earlier examinations of associations between environmental characteristics and active travel behaviour are limited by low spatial granularity and coverage of traditional data. Crowdsourced geographic information offers an opportunity to determine the fine-grained travel patterns of people...
June 15, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28614905/long-term-follow-up-of-chemoimmunotherapy-with-rituximab-oxaliplatin-cytosine-arabinoside-dexamethasone-road-in-patients-with-relapsed-cd20-b-cell-non-hodgkin-lymphoma-results-of-a-study-of-the-mayo-clinic-cancer-research-consortium-mccrc-mc0485-now-known-as
#18
Thomas E Witzig, Patrick B Johnston, Betsy R LaPlant, Paul J Kurtin, Levi D Pederson, Dennis F Moore, Nassim H Nabbout, Daniel A Nikcevich, Kendrith M Rowland, Axel Grothey
Patients with relapsed aggressive non-Hodgkin lymphoma (NHL) are often treated with platinum-based chemoimmunotherapy regimens in preparation for autologous stem cell transplant. We sought to reduce toxicity and maintain efficacy by using oxaliplatin with rituximab, cytarabine and dexamethasone (ROAD) in a phase II clinical trial in patients who had relapsed after one prior regimen. ROAD was delivered q21 days and consisted of rituximab 375 mg/m2 IV weekly x 4 doses (cycle 1 only); dexamethasone 40 mg PO/IV d2 - 5; oxaliplatin 130 mg/m2 IV d2; cytarabine 2000 mg/m2 IV x two doses on days 2 - 3; and pegfilgrastim 6 mg SC on d4...
June 14, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28609580/metabolic-defense-against-oxidative-stress-the-road-less-travelled-so-far
#19
REVIEW
Joe Lemire, Azhar Alhasawi, Varun P Appanna, Sujeenthar Tharmalingam, Vasu D Appanna
Bacteria have survived, and many have thrived, since antiquity in the presence of the highly-reactive chalcogen - oxygen (O2 ). They are known to evoke intricate strategies to defend themselves from the reactive by-products of oxygen - reactive oxygen species (ROS). Many of these detoxifying mechanisms have been extensively characterized; superoxide dismutase (SOD), catalases, alkyl hydroperoxide reductase and the glutathione (GSH)-cycling system are responsible for neutralizing specific ROS. Meanwhile, a pool of NADPH - the reductive engine of many ROS-combating enzymes - is maintained by metabolic enzymes including, but not exclusively, glucose-6 phosphate dehydrogenase (G6PDH) and NADP-dependent isocitrate dehydrogenase (ICDH-NADP)...
June 13, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28605841/characterizing-copper-flows-in-international-trade-of-china-1975-2015
#20
Ling Zhang, Tianming Chen, Jiameng Yang, Zhijian Cai, Hu Sheng, Zengwei Yuan, Huijun Wu
Since the economic reform, China has actively participated in the global market with rapid industrialization and gradually dominated the utilization and consumption of some critical materials, one of which is copper. China has reigned the global anthropogenic cycle of copper since 2004. We explore copper flows along with the international trade of China during 1975-2015, through life cycle lens, from ore to final products. Our main finding is that China has become more active in the copper-related trade, indicated by its great increase in trade volume and the number of trade partners...
June 6, 2017: Science of the Total Environment
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