keyword
MENU ▼
Read by QxMD icon Read
search

Alzehimer

keyword
https://www.readbyqxmd.com/read/27467324/-some-aspects-of-the-immune-system-in-the-pathogenesis-of-alzehimers%C3%A2-disease
#1
Z Chmátalová, A Skoumalová
Alzheimers disease is a severe neurodegenerative disorder and the most common cause of dementia in the population above 60 years of age. Beta-amyloid accumulation and neurofibrillary tangles formation in the brain precedes the development of Alzheimer's dementia by many years. As beta-amyloid accumulation inhibition failed as a treatment option, the theories on the Alzheimers disease pathophysio-lo-gy are being revised. In this context, research targets the role of inflammation as the possible trigger mechanism and accompanying process of neurodegeneration...
2016: Epidemiologie, Mikrobiologie, Imunologie
https://www.readbyqxmd.com/read/24467234/influence-of-electronic-and-formulation-variables-on-transdermal-iontophoresis-of-tacrine-hydrochloride
#2
Niketkumar Patel, Shashank Jain, Parshotam Madan, Senshang Lin
Freshly excised rat skin and side-by-side permeation cells were used to study the effect of electronic and formulation variables on transdermal iontophoretic delivery of tacrine. Current strength at 0.1-0.3 mA was observed to be the driving force resulting in tacrine permation flux of 30.3-366.6 μg/cm(2)/h. Depot formation of tacrine and altered skin permeability resulted in post iontophoretic flux even after termination of applied current. Increase in the duration of current application did not show significant difference in tacrine permeation flux upto 6 h...
June 2015: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/12235808/-dynamic-neuropathology-of-tauopathy
#3
REVIEW
S Murayama
Tauopathy is defined as abnormal accumulation of aberrantly phosphorylated microtubule-associated protein tau in the central nervous system, best demonstrated by immunocytochemistry using anti-tau antibodies. The newly recognized familial tauopathy with mutation in tau gene, that is located on chromosome 17, confirms that the process directly leads to neuronal degeneration. Tau consists of six isoforms translated from alternative splicing of a single gene. They are classified into three repeat (3R) and four repeat (4R) subtypes, by the number of microtubulus-binding domain from the reading or skipping of the exon 10...
December 2001: Rinshō Shinkeigaku, Clinical Neurology
1
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"