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Juyoung Park, Muna Aryal, Natalia Vykhodtseva, Yong-Zhi Zhang, Nathan McDannold
Drug delivery in brain tumors is challenging because of the presence of blood-brain barrier (BBB) and the blood-tumor barrier (BTB). Focused ultrasound (FUS) combined with microbubbles can enhance the permeability of the BTB in brain tumors, as well as disrupting the BBB in the surrounding tissue. In this study, dynamic contrast-enhanced Magnetic Resonance Imaging (DCE-MRI) was used to characterize FUS-induced permeability changes in a rat glioma model and in the normal brain and to investigate the relationship between these changes and the resulting concentration of the chemotherapy agent doxorubicin (DOX)...
October 11, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
Mohamed Amine Bani, Alia Zehani, Ines Chelly, Aida Khadhar, Haifa Azouz, Hafedh Jemel, Slim Haouet, Nidhameddine Kchir
No abstract text is available yet for this article.
April 2016: La Tunisie Médicale
Alexander Mason, Alan T Villavicencio, Ewell L Nelson, Robert C Forsythe, Sigita Burneikiene
Only four primary gliosarcoma case reports are described in the literature with transcranial (intradural to extradural) penetration into the region of the infratemporal fossa. This is the first report of a primary glioblastoma (GBM) that evolved into secondary or post-treatment gliosarcoma without evidence of a second de novo tumor and with extension into the left pterygomaxillary fossa.
July 18, 2016: Curēus
J Frandsen, A Orton, D C Shrieve, R L Jensen, H Colman, A Cohen, G Suneja
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Ugan Singh Meena, Sumit Sharma, Sanjeev Chopra, Shashi Kant Jain
Gliosarcoma is rare central nervous system tumour and a variant of glioblastoma multiforme with bimorphic histological pattern of glial and sarcomatous differentiation. It occurs in elderly between 5(th) and 6(th) decades of life and extremely rare in children. It is highly aggressive tumour and managed like glioblastoma multiforme. A 12-year-old female child presented with complaints of headache and vomiting from 15 d and blurring of vision from 3 d. Magnetic resonance imaging of brain shows heterogeneous mass in right parieto-occipital cortex...
September 16, 2016: World Journal of Clinical Cases
Carina Stegmayr, Ulrike Bandelow, Dennis Oliveira, Philipp Lohmann, Antje Willuweit, Christian Filss, Norbert Galldiks, Joachim H R Lübke, N Jon Shah, Johannes Ermert, Karl-Josef Langen
PURPOSE: O-(2-(18)F-fluoroethyl)-L-tyrosine ((18)F-FET) is an established tracer for the diagnosis of brain tumors with PET. This study investigates the influence of blood-brain barrier (BBB) permeability on (18)F-FET uptake in two rat glioma models and one human xenograft model. METHODS: F98 glioma, 9L gliosarcoma or human U87 glioblastoma cells were implanted into the striatum of 56 Fischer or RNU rats. Thereafter, animals were divided into a control group and a group receiving injections of the glucocorticoid dexamethasone (Dex)...
September 9, 2016: European Journal of Nuclear Medicine and Molecular Imaging
James Lee, Fausto Rodriguez, Syed Z Ali
Gliosarcoma is a rare variant of glioblastoma multiforme characterized by a biphasic pattern of glial and mesenchymal differentiation. Fine-needle aspiration (FNA) is routinely employed to diagnose a number of primary and secondary malignancies in a variety of clinical settings. Herein, we describe the cytomorphologic features of a gliosarcoma metastatic to an extracranial location accompanied by corresponding clinico-radiologic and histopathologic findings in a 51-year-old man with a posterior mediastinal mass...
September 2, 2016: Acta Cytologica
Peter Raab, Ulrich Pilatus, Elke Hattingen, Kea Franz, Elvis Hermann, Friedhelm E Zanella, Heinrich Lanfermann
OBJECTIVE: To evaluate the spectroscopic pattern of gliosarcomas for differentiation from glioblastomas or metastases. METHODS: H-nuclear magnetic resonance (NMR) spectroscopic intermediate echo time data of 5 patients with histologically proven gliosarcomas were compared with data of 17 metastases and 54 glioblastomas. Specialized H-NMR spectroscopy analysis software was used offline. Lipid and macromolecular resonances between 0.9 ppm and 1.4 ppm were compared besides the main metabolites using the Mann-Whitney U test...
September 2016: Journal of Computer Assisted Tomography
Kejia Cai, Rong-Wen Tain, Xiaohong Joe Zhou, Frederick C Damen, Alessandro M Scotti, Hari Hariharan, Harish Poptani, Ravinder Reddy
PURPOSE: Creatine (Cr) is a major metabolite in the bioenergetic system. Measurement of Cr using conventional MR spectroscopy (MRS) suffers from low spatial resolution and relatively long acquisition times. Creatine chemical exchange saturation transfer (CrCEST) magnetic resonance imaging (MRI) is an emerging molecular imaging method for tissue Cr measurements. Our previous study showed that the CrCEST contrast, obtained through multicomponent Z-spectral fitting, was lower in tumors compared to normal brain, which further reduced with tumor progression...
August 19, 2016: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
Milena Guidi, Laura Giunti, Maurizio Lucchesi, Silvia Scoccianti, Sabrina Giglio, Claudio Favre, Giuseppe Oliveri, Iacopo Sardi
No abstract text is available yet for this article.
August 15, 2016: Future Oncology
So-Ra Kim, Eun-Hee Kim
PURPOSE: The influence of short-term exposure to an acidic environment on the radiosensitivity of tumor cells has been extensively explored, but the implication of chronic exposure to an acidic environment for the response of tumor cells to radiation has not been fully elucidated. This study aimed to investigate the effects of chronic pre- and post-irradiation exposure of tumor cells to an acidic environment on the radiation-induced clonogenic death. MATERIALS AND METHODS: Rat gliosarcoma cells were used throughout the in vitro study...
September 2016: International Journal of Radiation Biology
Sarah T Garber, Yuuri Hashimoto, Shiao-Pei Weathers, Joanne Xiu, Zoran Gatalica, Roel G W Verhaak, Shouhao Zhou, Gregory N Fuller, Mustafa Khasraw, John de Groot, Sandeep K Reddy, David Spetzler, Amy B Heimberger
BACKGROUND: Expression of programmed cell death protein 1 (PD-1)/programmed death ligand 1 (PD-L1) across glioma grades is undocumented, and their interactions with commonly expressed genetic and epigenetic alterations are undefined but nonetheless highly relevant to combinatorial treatments. METHODS: Patients with CNS malignancies were profiled by Caris Life Sciences from 2009 to 2016. Immunohistochemistry findings for PD-1 on tumor-infiltrating lymphocytes (TIL) and PD-L1 on tumor cells were available for 347 cases...
October 2016: Neuro-oncology
Felix Behling, Alonso Barrantes-Freer, Marco Skardelly, Maike Nieser, Arne Christians, Florian Stockhammer, Veit Rohde, Marcos Tatagiba, Christian Hartmann, Christine Stadelmann, Jens Schittenhelm
BACKGROUND: Treatment options for oncological diseases have been enhanced by the advent of targeted therapies. The point mutation of the BRAF gene at codon 600 (BRAF V600E) is found in several tumor entities and can be approached with selective inhibitory antibodies. The BRAF inhibitor vemurafenib has demonstrated clinical efficacy in patients with BRAF V600E-mutant melanoma brain metastases and in other cancer diseases. Therefore the BRAF V600E mutation is a highly interesting oncological target in brain tumors...
2016: Diagnostic Pathology
Hongzhou Duan, Kazuo Kitazawa, Takehiro Yako, Shunsuke Ichinose, Shigeaki Kobayashi, Motohiro Sudo
BACKGROUND: Gliosarcoma is a relatively rare and bimorphous brain tumor, predominantly located in the brain lobe. Here, we report a rare case of gliosarcoma presenting radiologically in the cerebellopontine angle (CPA) region. CASE DESCRIPTION: The patient was a 71-year-old woman with progressive tinnitus. A series of image examinations showed a rapidly growing CPA tumor, which enlarged from nonexistent to 4 cm in diameter with extension to the internal auditory canal in a short period of 6 months...
August 2016: World Neurosurgery
Daxa M Patel, Paul M Foreman, L Burt Nabors, Kristen O Riley, G Yancey Gillespie, James M Markert
M032 is a second-generation oncolytic herpes simplex virus (oHSV) that selectively replicates in tumor cells. M032 kills tumor cells directly through oncolytic replication and then proceeds to infect tumor cells in proximity, continuing the process of tumor destruction. In addition to this direct oncolytic activity, the virus carries a therapeutic payload-thus acting as a gene therapy vector-and causes the tumor cell to synthesize and secrete the immunity-stimulating protein interleukin-12 (IL-12) before cell death...
June 2016: Human Gene Therapy. Clinical Development
Joseph R Kapurch, Jeffrey T Jacob, Matthew L Carlson, John L Atkinson, Aditya Raghunathan, Michael J Link
OBJECTIVE: Secondary tumorigenesis after exposure to ionizing radiation is a well-described phenomenon. The probability of developing a malignancy after stereotactic radiosurgery (SRS) is theoretically less than conventional external beam radiation therapy; however, the exact risk remains unknown. Such information is important for patient counseling when considering treatment of benign conditions such as vestibular schwannoma (VS). The objective of the current report is to describe a case of a temporal lobe gliosarcoma developing 3 years after radiosurgical treatment of a sporadic VS...
September 2016: Otology & Neurotology
G Laurent, C Bernhard, S Dufort, G Jiménez Sánchez, R Bazzi, F Boschetti, M Moreau, T H Vu, B Collin, A Oudot, N Herath, H Requardt, S Laurent, L Vander Elst, R Muller, M Dutreix, M Meyer, F Brunotte, P Perriat, F Lux, O Tillement, G Le Duc, F Denat, S Roux
Many studies have been devoted to adapting the design of gold nanoparticles to efficiently exploit their promising capability to enhance the effects of radiotherapy. In particular, the addition of magnetic resonance imaging modality constitutes an attractive strategy for enhancing the selectivity of radiotherapy since it allows the determination of the most suited delay between the injection of nanoparticles and irradiation. This requires the functionalization of the gold core by an organic shell composed of thiolated gadolinium chelates...
June 9, 2016: Nanoscale
Daxa Patel, Paul Foreman, Burt Nabors, Kristen Riley, Yancey Gillespie, James Markert
M032 is a second-generation oncolytic herpes simplex virus (oHSV) that selectively replicates in tumor cells. M032 kills tumor cells directly through oncolytic replication then proceeds to infect tumor cells in proximity, continuing the process of tumor destruction. In addition to this direct oncolytic activity, the virus carries a therapeutic payload-thus acting as a gene therapy vector-and causes the tumor cell to synthesize and secrete the immunity-stimulating protein interleukin-12 (IL-12) prior to cell death...
May 27, 2016: Human Gene Therapy. Clinical Development
Fa-Ke Lu, David Calligaris, Olutayo I Olubiyi, Isaiah Norton, Wenlong Yang, Sandro Santagata, X Sunney Xie, Alexandra J Golby, Nathalie Y R Agar
The goal of brain tumor surgery is to maximize tumor removal without injuring critical brain structures. Achieving this goal is challenging as it can be difficult to distinguish tumor from nontumor tissue. While standard histopathology provides information that could assist tumor delineation, it cannot be performed iteratively during surgery as freezing, sectioning, and staining of the tissue require too much time. Stimulated Raman scattering (SRS) microscopy is a powerful label-free chemical imaging technology that enables rapid mapping of lipids and proteins within a fresh specimen...
June 15, 2016: Cancer Research
J Castelli, L Feuvret, Q C Haoming, J Biau, E Jouglar, A Berger, G Truc, F Llamas Gutierrez, X Morandi, P J Le Reste, F Thillays, D Loussouarn, E Nouhaud, G Crehange, D Antoni, E Vauleon, R de Crevoisier, G Noel
The aims of this multicentre retrospective study were to identify prognostic or therapeutic factors impacting on overall survival in patients with gliosarcoma. The analysis included all patients treated for gliosarcoma between 1998 and 2014 in seven French academic centres. Seventy-five patients with a median age of 60 years (range from 23 to 79 years) were treated with a combination of surgery (n = 66), radiotherapy (adjuvant for 64 patients and exclusive for 8 patients) and temozolomide based chemotherapy (n = 58)...
August 2016: Journal of Neuro-oncology
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