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https://www.readbyqxmd.com/read/28327297/first-proof-of-bismuth-oxide-nanoparticles-as-efficient-radiosensitisers-on-highly-radioresistant-cancer-cells
#1
Callum Stewart, Konstantin Konstantinov, Sally McKinnon, Susanna Guatelli, Michael Lerch, Anatoly Rosenfeld, Moeava Tehei, Stéphanie Corde
This study provides the first proof of the novel application of bismuth oxide as a radiosensitiser. It was shown that on the highly radioresistant 9L gliosarcoma cell line, bismuth oxide nanoparticles sensitise to both kilovoltage (kVp) or megavoltage (MV) X-rays radiation. 9L cells were exposed to a concentration of 50μg.mL(-1) of nanoparticle before irradiation at 125kVp and 10MV. Sensitisation enhancement ratios of 1.48 and 1.25 for 125kVp and 10MV were obtained in vitro, respectively. The radiation enhancement of the nanoparticles is postulated to be a combination of the high Z nature of the bismuth (Z=83), and the surface chemistry...
November 2016: Physica Medica: PM
https://www.readbyqxmd.com/read/28288892/mr-image-guided-delivery-of-cisplatin-loaded-brain-penetrating-nanoparticles-to-invasive-glioma-with-focused-ultrasound
#2
Kelsie F Timbie, Umara Afzal, Abhijit Date, Clark Zhang, Ji Song, G Wilson Miller, Jung Soo Suk, Justin Hanes, Richard J Price
Systemically administered chemotherapeutic drugs are often ineffective in the treatment of invasive brain tumors due to poor therapeutic index. Within gliomas, despite the presence of heterogeneously leaky microvessels, dense extracellular matrix and high interstitial pressure generate a "blood-tumor barrier" (BTB), which inhibits drug delivery and distribution. Meanwhile, beyond the contrast MRI-enhancing edge of the tumor, invasive cancer cells are protected by the intact blood-brain barrier (BBB). Here, we tested whether brain-penetrating nanoparticles (BPN) that possess dense surface coatings of polyethylene glycol (PEG) and are loaded with cisplatin (CDDP) could be delivered across both the blood-tumor and blood-brain barriers with MR image-guided focused ultrasound (MRgFUS), and whether this treatment could control glioma growth and invasiveness...
March 11, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28261869/intraventricular-gliosarcoma-with-dual-sarcomatous-differentiation-a-unique-case
#3
Rajalakshmi Poyuran, Nandeesh Bn, Yerasi Varun Kumar Reddy, Amey R Savardekar
Gliosarcoma, a variant of isocitrate dehydrogenase-wildtype glioblastoma, is largely a lobar surfacing neoplasm often with dural attachment. In this biphasic neoplasm, the sarcomatous component usually takes the form of fibrosarcoma or malignant fibrous histiocytoma. Heterologous sarcomatous differentiation is a rare phenomenon. Here, we present a case of gliosarcoma with liposarcomatous and myosarcomatous differentiation in a 68-year-old man which was purely intraventricular. This is the first report of such a morphologic pattern in this location...
March 6, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/28180935/clinicopathological-features-and-microsurgical-outcomes-for-giant-pediatric-intracranial-tumor-in-60-consecutive-cases
#4
Ailing Guo, Vigneyshwar Suresh, Xianzhi Liu, Fuyou Guo
PURPOSE: Giant pediatric intracranial tumor (GPIT) remains to be a challenging disease with high morbidity and mortality. METHODS: The clinical data of 60 patients under 18 years of age operated on with GPIT (≥5 cm in diameter) were retrospectively analyzed. RESULTS: Gross total resection was achieved in 46 cases (77%) and subtotal resection was obtained in 14 cases (23%). Ninety percent (47/52) of the cases with obstructive hydrocephalus were resolved remarkably and only 10% (5/52) of the patients needed a ventriculoperitoneal shunt after tumor resection...
February 8, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28161760/incidence-survival-pathology-and-genetics-of-adult-latino-americans-with-glioblastoma
#5
Maryam Shabihkhani, Donatello Telesca, Masoud Movassaghi, Yalda B Naeini, Kourosh M Naeini, Seyed Amin Hojat, Diviya Gupta, Gregory M Lucey, Michael Ontiveros, Michael W Wang, Lauren S Hanna, Desiree E Sanchez, Sergey Mareninov, Negar Khanlou, Harry V Vinters, Marvin Bergsneider, Phioanh Leia Nghiemphu, Albert Lai, Linda M Liau, Timothy F Cloughesy, William H Yong
Latino Americans are a rapidly growing ethnic group in the United States but studies of glioblastoma in this population are limited. We have evaluated characteristics of 21,184 glioblastoma patients from the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute. This SEER data from 2001 to 2011 draws from 28% of the U.S. POPULATION: Latinos have a lower incidence of GBM and present slightly younger than non-Latino Whites. Cubans present at an older age than other Latino sub-populations...
February 4, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/27975329/density-dependent-regulation-of-glioma-cell-proliferation-and-invasion-mediated-by-mir-9
#6
Mark Katakowski, Nicholas Charteris, Michael Chopp, Evgeniy Khain
The phenotypic axis of invasion and proliferation in malignant glioma cells is a well-documented phenomenon. Invasive glioma cells exhibit a decreased proliferation rate and a resistance to apoptosis, and invasive tumor cells dispersed in brain subsequently revert to proliferation and contribute to secondary tumor formation. One miRNA can affect dozens of mRNAs, and some miRNAs are potent oncogenes. Multiple miRNAs are implicated in glioma malignancy, and several of which have been identified to regulate tumor cell motility and division...
December 2016: Cancer Microenvironment: Official Journal of the International Cancer Microenvironment Society
https://www.readbyqxmd.com/read/27951723/-a-patient-with-primary-intraventricular-gliosarcoma-and-long-term-survival-a-case-report
#7
O Kalita, M Zlevorová, M Megová, M Vaverka, R Trojanec, L Tučková
BACKGROUND: Gliosarcoma is a rare, malignant CNS tumor with a very poor prognosis. Gliosarcoma is a variant of glioblastoma multiforme, which is characterized by the presence of both glial and mesenchymal components. The treatment strategy for gliosarcomas has not yet been determined clearly. CASE PRESENTATION: This case report presents a 23-year-old female patient who complained of increasing headaches, nausea and vomiting, and slight motor weakness in her left arm...
2016: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/27941882/use-of-an-anti-viral-drug-ribavirin-as-an-anti-glioblastoma-therapeutic
#8
F Volpin, J Casaos, J Sesen, A Mangraviti, J Choi, N Gorelick, J Frikeche, T Lott, R Felder, S J Scotland, T S K Eisinger-Mathason, H Brem, B Tyler, N Skuli
The median survival for glioblastoma patients is ~15 months despite aggressive surgery and radio-chemotherapy approaches. Thus, developing new therapeutics is necessary to improve the treatment of these invasive brain tumors, which are known to show high levels of the eukaryotic initiation factor, eIF4E, a potent oncogene. Ribavirin, the only clinically approved drug known to target eIF4E, is an anti-viral molecule currently used in hepatitis C treatment. Here, we report the effect of ribavirin on proliferation, cell cycle, cell death and migration of several human and murine glioma cell lines, as well as human glioblastoma stem-like cells, in vitro...
December 12, 2016: Oncogene
https://www.readbyqxmd.com/read/27899174/concurrent-gliosarcoma-and-choroid-plexus-carcinoma-in-a-cow
#9
A Ortloff, J Neumann, O Illanes
Brain tumours in cattle are uncommon and the spontaneous development of primary brain tumours of different histological types is rare in both man and animals. In man, multiple concurrent primary tumours of different types are occasionally described. We report the rare simultaneous occurrence of two different primary brain tumours, gliosarcoma and choroid plexus carcinoma, diagnosed by microscopical and immunofluorescence evaluation in an 8-year-old cow with a 2-month history of neurological disease. Gliosarcoma is a rare variant of glioblastoma multiforme, characterized by the presence of malignant glial cells and mesenchymal tissue...
January 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/27867925/a-stable-secondary-gliosarcoma-with-extensive-systemic-metastases-a-case-report
#10
Tae-Min Choi, Young-Jun Cheon, Tae-Young Jung, Kyung-Hwa Lee
A 63-year-old man complained of intermittent motor weakness of his arm. The magnetic resonance image (MRI) of his brain displayed a high signal lesion in right cingulate gyrus on T2 weighted image. One year later, he showed a stuporous mental status with repeated seizures, and the follow-up brain MRI showed heterogeneously enhanced mass associated with bleeding. He was treated with surgery and radiotherapy for secondary glioblastomas in right cingulate gyrus. One year more later, a mass recurred on the left frontal base, and gliosarcoma was diagnosed...
October 2016: Brain Tumor Research and Treatment
https://www.readbyqxmd.com/read/27866898/optimizing-dose-enhancement-with-ta2o5-nanoparticles-for-synchrotron-microbeam-activated-radiation-therapy
#11
Elette Engels, Stéphanie Corde, Sally McKinnon, Sébastien Incerti, Konstantin Konstantinov, Anatoly Rosenfeld, Moeava Tehei, Michael Lerch, Susanna Guatelli
Microbeam Radiation Therapy (MRT) exploits tumour selectivity and normal tissue sparing with spatially fractionated kilovoltage X-ray microbeams through the dose volume effect. Experimental measurements with Ta2O5 nanoparticles (NPs) in 9L gliosarcoma treated with MRT at the Australian Synchrotron, increased the treatment efficiency. Ta2O5 NPs were observed to form shells around cell nuclei which may be the reason for their efficiency in MRT. In this article, our experimental observation of NP shell formation is the basis of a Geant4 radiation transport study to characterise dose enhancement by Ta2O5 NPs in MRT...
December 2016: Physica Medica: PM
https://www.readbyqxmd.com/read/27792048/primary-gliosarcoma-of-the-optic-nerve-a-unique-adult-optic-pathway-glioma
#12
Patrick J Cimino, Yevgeniy V Sychev, Luis F Gonzalez-Cuyar, Raghu C Mudumbai, C Dirk Keene
A 90-year-old woman presented with 1-year history of right-sided progressive proptosis, neovascular glaucoma, blindness, and worsening ocular pain. No funduscopic examination was possible because of a corneal opacity. Head CT scan without contrast demonstrated a heterogeneous 4.1 cm (anterior-posterior) by 1.7 cm (transverse) cylindrical mass arising in the right optic nerve and extending from the retrobulbar globe to the optic canal. She underwent palliative enucleation with subtotal resection of the orbital optic nerve and tumor...
October 11, 2016: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27772848/gliosarcoma-with-a-primitive-neuroectodermal-tumour-component
#13
C Green, B Dessauvagie, P Robbins
No abstract text is available yet for this article.
February 2016: Pathology
https://www.readbyqxmd.com/read/27771113/-cerebral-primitive-osteosarcoma-a-radiological-and-histological-atypia
#14
K M H Ahanogbe, K Ibahioin, M Karkouri, M B Dianka, W Akpo, A El Azhari
INTRODUCTION: Osteosarcoma is a malignant mesenchymal tumor including cells that present an osteoblastic differentiation. On the skull, it has often extra-axial development associated with bone reaction. We report an atypical and rare case of intracranial or cerebral osteosarcoma underline the radiological and pathological diagnostic difficulties. CASE REPORT: Our case concerns a primary osteosarcoma without bone involvement in a 10-year old boy who was admitted for intracranial hypertension with progressive worsening and brachial monoparesis...
October 2016: Neuro-Chirurgie
https://www.readbyqxmd.com/read/27742444/evaluation-of-permeability-doxorubicin-delivery-and-drug-retention-in-a-rat-brain-tumor-model-after-ultrasound-induced-blood-tumor-barrier-disruption
#15
Juyoung Park, Muna Aryal, Natalia Vykhodtseva, Yong-Zhi Zhang, Nathan McDannold
Drug delivery in brain tumors is challenging because of the presence of blood-brain barrier (BBB) and the blood-tumor barrier (BTB). Focused ultrasound (FUS) combined with microbubbles can enhance the permeability of the BTB in brain tumors, as well as disrupting the BBB in the surrounding tissue. In this study, dynamic contrast-enhanced Magnetic Resonance Imaging (DCE-MRI) was used to characterize FUS-induced permeability changes in a rat glioma model and in the normal brain and to investigate the relationship between these changes and the resulting concentration of the chemotherapy agent doxorubicin (DOX)...
October 11, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27704522/gliosarcoma-with-smooth-muscle-cell-differentiation-a-case-report
#16
Mohamed Amine Bani, Alia Zehani, Ines Chelly, Aida Khadhar, Haifa Azouz, Hafedh Jemel, Slim Haouet, Nidhameddine Kchir
No abstract text is available yet for this article.
April 2016: La Tunisie Médicale
https://www.readbyqxmd.com/read/27699141/post-treatment-gliosarcoma-extension-into-the-pterygomaxillary-fossa-literature-review-and-case-report
#17
REVIEW
Alexander Mason, Alan T Villavicencio, Ewell L Nelson, Robert C Forsythe, Sigita Burneikiene
Only four primary gliosarcoma case reports are described in the literature with transcranial (intradural to extradural) penetration into the region of the infratemporal fossa. This is the first report of a primary glioblastoma (GBM) that evolved into secondary or post-treatment gliosarcoma without evidence of a second de novo tumor and with extension into the left pterygomaxillary fossa.
July 18, 2016: Curēus
https://www.readbyqxmd.com/read/27675512/patterns-of-care-and-outcomes-analysis-for-gliosarcoma-a-national-cancer-data-base-project
#18
J Frandsen, A Orton, D C Shrieve, R L Jensen, H Colman, A Cohen, G Suneja
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27672648/gliosarcoma-a-rare-variant-of-glioblastoma-multiforme-in-paediatric-patient-case-report-and-review-of-literature
#19
Ugan Singh Meena, Sumit Sharma, Sanjeev Chopra, Shashi Kant Jain
Gliosarcoma is rare central nervous system tumour and a variant of glioblastoma multiforme with bimorphic histological pattern of glial and sarcomatous differentiation. It occurs in elderly between 5(th) and 6(th) decades of life and extremely rare in children. It is highly aggressive tumour and managed like glioblastoma multiforme. A 12-year-old female child presented with complaints of headache and vomiting from 15 d and blurring of vision from 3 d. Magnetic resonance imaging of brain shows heterogeneous mass in right parieto-occipital cortex...
September 16, 2016: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/27613541/influence-of-blood-brain-barrier-permeability-on-o-2-18-f-fluoroethyl-l-tyrosine-uptake-in-rat-gliomas
#20
Carina Stegmayr, Ulrike Bandelow, Dennis Oliveira, Philipp Lohmann, Antje Willuweit, Christian Filss, Norbert Galldiks, Joachim H R Lübke, N Jon Shah, Johannes Ermert, Karl-Josef Langen
PURPOSE: O-(2-(18)F-fluoroethyl)-L-tyrosine ((18)F-FET) is an established tracer for the diagnosis of brain tumors with PET. This study investigates the influence of blood-brain barrier (BBB) permeability on (18)F-FET uptake in two rat glioma models and one human xenograft model. METHODS: F98 glioma, 9L gliosarcoma or human U87 glioblastoma cells were implanted into the striatum of 56 Fischer or RNU rats. Thereafter, animals were divided into a control group and a group receiving injections of the glucocorticoid dexamethasone (Dex)...
March 2017: European Journal of Nuclear Medicine and Molecular Imaging
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