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https://www.readbyqxmd.com/read/27899174/concurrent-gliosarcoma-and-choroid-plexus-carcinoma-in-a-cow
#1
A Ortloff, J Neumann, O Illanes
Brain tumours in cattle are uncommon and the spontaneous development of primary brain tumours of different histological types is rare in both man and animals. In man, multiple concurrent primary tumours of different types are occasionally described. We report the rare simultaneous occurrence of two different primary brain tumours, gliosarcoma and choroid plexus carcinoma, diagnosed by microscopical and immunofluorescence evaluation in an 8-year-old cow with a 2-month history of neurological disease. Gliosarcoma is a rare variant of glioblastoma multiforme, characterized by the presence of malignant glial cells and mesenchymal tissue...
November 26, 2016: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/27867925/a-stable-secondary-gliosarcoma-with-extensive-systemic-metastases-a-case-report
#2
Tae-Min Choi, Young-Jun Cheon, Tae-Young Jung, Kyung-Hwa Lee
A 63-year-old man complained of intermittent motor weakness of his arm. The magnetic resonance image (MRI) of his brain displayed a high signal lesion in right cingulate gyrus on T2 weighted image. One year later, he showed a stuporous mental status with repeated seizures, and the follow-up brain MRI showed heterogeneously enhanced mass associated with bleeding. He was treated with surgery and radiotherapy for secondary glioblastomas in right cingulate gyrus. One year more later, a mass recurred on the left frontal base, and gliosarcoma was diagnosed...
October 2016: Brain Tumor Research and Treatment
https://www.readbyqxmd.com/read/27866898/optimizing-dose-enhancement-with-ta2o5-nanoparticles-for-synchrotron-microbeam-activated-radiation-therapy
#3
Elette Engels, Stéphanie Corde, Sally McKinnon, Sébastien Incerti, Konstantin Konstantinov, Anatoly Rosenfeld, Moeava Tehei, Michael Lerch, Susanna Guatelli
Microbeam Radiation Therapy (MRT) exploits tumour selectivity and normal tissue sparing with spatially fractionated kilovoltage X-ray microbeams through the dose volume effect. Experimental measurements with Ta2O5 nanoparticles (NPs) in 9L gliosarcoma treated with MRT at the Australian Synchrotron, increased the treatment efficiency. Ta2O5 NPs were observed to form shells around cell nuclei which may be the reason for their efficiency in MRT. In this article, our experimental observation of NP shell formation is the basis of a Geant4 radiation transport study to characterise dose enhancement by Ta2O5 NPs in MRT...
November 17, 2016: Physica Medica: PM
https://www.readbyqxmd.com/read/27792048/primary-gliosarcoma-of-the-optic-nerve-a-unique-adult-optic-pathway-glioma
#4
Patrick J Cimino, Yevgeniy V Sychev, Luis F Gonzalez-Cuyar, Raghu C Mudumbai, C Dirk Keene
A 90-year-old woman presented with 1-year history of right-sided progressive proptosis, neovascular glaucoma, blindness, and worsening ocular pain. No funduscopic examination was possible because of a corneal opacity. Head CT scan without contrast demonstrated a heterogeneous 4.1 cm (anterior-posterior) by 1.7 cm (transverse) cylindrical mass arising in the right optic nerve and extending from the retrobulbar globe to the optic canal. She underwent palliative enucleation with subtotal resection of the orbital optic nerve and tumor...
October 11, 2016: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27772848/gliosarcoma-with-a-primitive-neuroectodermal-tumour-component
#5
C Green, B Dessauvagie, P Robbins
No abstract text is available yet for this article.
February 2016: Pathology
https://www.readbyqxmd.com/read/27771113/-cerebral-primitive-osteosarcoma-a-radiological-and-histological-atypia
#6
K M H Ahanogbe, K Ibahioin, M Karkouri, M B Dianka, W Akpo, A El Azhari
INTRODUCTION: Osteosarcoma is a malignant mesenchymal tumor including cells that present an osteoblastic differentiation. On the skull, it has often extra-axial development associated with bone reaction. We report an atypical and rare case of intracranial or cerebral osteosarcoma underline the radiological and pathological diagnostic difficulties. CASE REPORT: Our case concerns a primary osteosarcoma without bone involvement in a 10-year old boy who was admitted for intracranial hypertension with progressive worsening and brachial monoparesis...
October 19, 2016: Neuro-Chirurgie
https://www.readbyqxmd.com/read/27742444/evaluation-of-permeability-doxorubicin-delivery-and-drug-retention-in-a-rat-brain-tumor-model-after-ultrasound-induced-blood-tumor-barrier-disruption
#7
Juyoung Park, Muna Aryal, Natalia Vykhodtseva, Yong-Zhi Zhang, Nathan McDannold
Drug delivery in brain tumors is challenging because of the presence of blood-brain barrier (BBB) and the blood-tumor barrier (BTB). Focused ultrasound (FUS) combined with microbubbles can enhance the permeability of the BTB in brain tumors, as well as disrupting the BBB in the surrounding tissue. In this study, dynamic contrast-enhanced Magnetic Resonance Imaging (DCE-MRI) was used to characterize FUS-induced permeability changes in a rat glioma model and in the normal brain and to investigate the relationship between these changes and the resulting concentration of the chemotherapy agent doxorubicin (DOX)...
October 11, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27704522/gliosarcoma-with-smooth-muscle-cell-differentiation-a-case-report
#8
Mohamed Amine Bani, Alia Zehani, Ines Chelly, Aida Khadhar, Haifa Azouz, Hafedh Jemel, Slim Haouet, Nidhameddine Kchir
No abstract text is available yet for this article.
April 2016: La Tunisie Médicale
https://www.readbyqxmd.com/read/27699141/post-treatment-gliosarcoma-extension-into-the-pterygomaxillary-fossa-literature-review-and-case-report
#9
Alexander Mason, Alan T Villavicencio, Ewell L Nelson, Robert C Forsythe, Sigita Burneikiene
Only four primary gliosarcoma case reports are described in the literature with transcranial (intradural to extradural) penetration into the region of the infratemporal fossa. This is the first report of a primary glioblastoma (GBM) that evolved into secondary or post-treatment gliosarcoma without evidence of a second de novo tumor and with extension into the left pterygomaxillary fossa.
July 18, 2016: Curēus
https://www.readbyqxmd.com/read/27675512/patterns-of-care-and-outcomes-analysis-for-gliosarcoma-a-national-cancer-data-base-project
#10
J Frandsen, A Orton, D C Shrieve, R L Jensen, H Colman, A Cohen, G Suneja
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27672648/gliosarcoma-a-rare-variant-of-glioblastoma-multiforme-in-paediatric-patient-case-report-and-review-of-literature
#11
Ugan Singh Meena, Sumit Sharma, Sanjeev Chopra, Shashi Kant Jain
Gliosarcoma is rare central nervous system tumour and a variant of glioblastoma multiforme with bimorphic histological pattern of glial and sarcomatous differentiation. It occurs in elderly between 5(th) and 6(th) decades of life and extremely rare in children. It is highly aggressive tumour and managed like glioblastoma multiforme. A 12-year-old female child presented with complaints of headache and vomiting from 15 d and blurring of vision from 3 d. Magnetic resonance imaging of brain shows heterogeneous mass in right parieto-occipital cortex...
September 16, 2016: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/27613541/influence-of-blood-brain-barrier-permeability-on-o-2-18-f-fluoroethyl-l-tyrosine-uptake-in-rat-gliomas
#12
Carina Stegmayr, Ulrike Bandelow, Dennis Oliveira, Philipp Lohmann, Antje Willuweit, Christian Filss, Norbert Galldiks, Joachim H R Lübke, N Jon Shah, Johannes Ermert, Karl-Josef Langen
PURPOSE: O-(2-(18)F-fluoroethyl)-L-tyrosine ((18)F-FET) is an established tracer for the diagnosis of brain tumors with PET. This study investigates the influence of blood-brain barrier (BBB) permeability on (18)F-FET uptake in two rat glioma models and one human xenograft model. METHODS: F98 glioma, 9L gliosarcoma or human U87 glioblastoma cells were implanted into the striatum of 56 Fischer or RNU rats. Thereafter, animals were divided into a control group and a group receiving injections of the glucocorticoid dexamethasone (Dex)...
September 9, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27584833/metastatic-gliosarcoma-cytopathologic-characteristics-with-histopathologic-correlations
#13
James Lee, Fausto Rodriguez, Syed Z Ali
Gliosarcoma is a rare variant of glioblastoma multiforme characterized by a biphasic pattern of glial and mesenchymal differentiation. Fine-needle aspiration (FNA) is routinely employed to diagnose a number of primary and secondary malignancies in a variety of clinical settings. Herein, we describe the cytomorphologic features of a gliosarcoma metastatic to an extracranial location accompanied by corresponding clinico-radiologic and histopathologic findings in a 51-year-old man with a posterior mediastinal mass...
2016: Acta Cytologica
https://www.readbyqxmd.com/read/27560009/spectroscopic-characterization-of-gliosarcomas-do-they-differ-from-glioblastomas-and-metastases
#14
Peter Raab, Ulrich Pilatus, Elke Hattingen, Kea Franz, Elvis Hermann, Friedhelm E Zanella, Heinrich Lanfermann
OBJECTIVE: To evaluate the spectroscopic pattern of gliosarcomas for differentiation from glioblastomas or metastases. METHODS: H-nuclear magnetic resonance (NMR) spectroscopic intermediate echo time data of 5 patients with histologically proven gliosarcomas were compared with data of 17 metastases and 54 glioblastomas. Specialized H-NMR spectroscopy analysis software was used offline. Lipid and macromolecular resonances between 0.9 ppm and 1.4 ppm were compared besides the main metabolites using the Mann-Whitney U test...
September 2016: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/27541025/creatine-cest-mri-for-differentiating-gliomas-with-different-degrees-of-aggressiveness
#15
Kejia Cai, Rong-Wen Tain, Xiaohong Joe Zhou, Frederick C Damen, Alessandro M Scotti, Hari Hariharan, Harish Poptani, Ravinder Reddy
PURPOSE: Creatine (Cr) is a major metabolite in the bioenergetic system. Measurement of Cr using conventional MR spectroscopy (MRS) suffers from low spatial resolution and relatively long acquisition times. Creatine chemical exchange saturation transfer (CrCEST) magnetic resonance imaging (MRI) is an emerging molecular imaging method for tissue Cr measurements. Our previous study showed that the CrCEST contrast, obtained through multicomponent Z-spectral fitting, was lower in tumors compared to normal brain, which further reduced with tumor progression...
August 19, 2016: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/27523101/brain-tumors-in-li-fraumeni-syndrome-a-commentary-and-a-case-of-a-gliosarcoma-patient
#16
Milena Guidi, Laura Giunti, Maurizio Lucchesi, Silvia Scoccianti, Sabrina Giglio, Claudio Favre, Giuseppe Oliveri, Iacopo Sardi
No abstract text is available yet for this article.
January 2017: Future Oncology
https://www.readbyqxmd.com/read/27415583/effects-of-chronic-exposure-to-acidic-environment-on-the-response-of-tumor-cells-to-radiation
#17
So-Ra Kim, Eun-Hee Kim
PURPOSE: The influence of short-term exposure to an acidic environment on the radiosensitivity of tumor cells has been extensively explored, but the implication of chronic exposure to an acidic environment for the response of tumor cells to radiation has not been fully elucidated. This study aimed to investigate the effects of chronic pre- and post-irradiation exposure of tumor cells to an acidic environment on the radiation-induced clonogenic death. MATERIALS AND METHODS: Rat gliosarcoma cells were used throughout the in vitro study...
September 2016: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/27370400/immune-checkpoint-blockade-as-a-potential-therapeutic-target-surveying-cns-malignancies
#18
Sarah T Garber, Yuuri Hashimoto, Shiao-Pei Weathers, Joanne Xiu, Zoran Gatalica, Roel G W Verhaak, Shouhao Zhou, Gregory N Fuller, Mustafa Khasraw, John de Groot, Sandeep K Reddy, David Spetzler, Amy B Heimberger
BACKGROUND: Expression of programmed cell death protein 1 (PD-1)/programmed death ligand 1 (PD-L1) across glioma grades is undocumented, and their interactions with commonly expressed genetic and epigenetic alterations are undefined but nonetheless highly relevant to combinatorial treatments. METHODS: Patients with CNS malignancies were profiled by Caris Life Sciences from 2009 to 2016. Immunohistochemistry findings for PD-1 on tumor-infiltrating lymphocytes (TIL) and PD-L1 on tumor cells were available for 347 cases...
October 2016: Neuro-oncology
https://www.readbyqxmd.com/read/27350555/frequency-of-braf-v600e-mutations-in-969-central-nervous-system-neoplasms
#19
Felix Behling, Alonso Barrantes-Freer, Marco Skardelly, Maike Nieser, Arne Christians, Florian Stockhammer, Veit Rohde, Marcos Tatagiba, Christian Hartmann, Christine Stadelmann, Jens Schittenhelm
BACKGROUND: Treatment options for oncological diseases have been enhanced by the advent of targeted therapies. The point mutation of the BRAF gene at codon 600 (BRAF V600E) is found in several tumor entities and can be approached with selective inhibitory antibodies. The BRAF inhibitor vemurafenib has demonstrated clinical efficacy in patients with BRAF V600E-mutant melanoma brain metastases and in other cancer diseases. Therefore the BRAF V600E mutation is a highly interesting oncological target in brain tumors...
2016: Diagnostic Pathology
https://www.readbyqxmd.com/read/27338213/gliosarcoma-in-the-cerebellopontine-angle-with-rapid-tumor-growth-and-intratumoral-hemorrhage
#20
Hongzhou Duan, Kazuo Kitazawa, Takehiro Yako, Shunsuke Ichinose, Shigeaki Kobayashi, Motohiro Sudo
BACKGROUND: Gliosarcoma is a relatively rare and bimorphous brain tumor, predominantly located in the brain lobe. Here, we report a rare case of gliosarcoma presenting radiologically in the cerebellopontine angle (CPA) region. CASE DESCRIPTION: The patient was a 71-year-old woman with progressive tinnitus. A series of image examinations showed a rapidly growing CPA tumor, which enlarged from nonexistent to 4 cm in diameter with extension to the internal auditory canal in a short period of 6 months...
August 2016: World Neurosurgery
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