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Meral Gunaldi, Nilgun Isiksacan, Hakan Kocoglu, Yildiz Okuturlar, Omur Gunaldi, Turkan Ozturk Topcu, Mehmet Karabulut
Objective: Survivin is one of the apoptosis inhibitor proteins, and it plays a key role in tumor angiogenesis and cancer progression. This study was conducted to investigate the serum level of survivin to determine its diagnostic value in cancer patients. Materials and Methods: Blood samples were taken from cancer patients (n = 67) prior to surgery or chemo/radiotherapy and age-matched healthy volunteers (n = 23). The serum levels of survivin were analyzed by enzyme-linked immunosorbent assays...
April 2018: Journal of Cancer Research and Therapeutics
Dieter Henrik Heiland, Jakob Wörner, Jan Gerrit Haaker, Daniel Delev, Nils Pompe, Bianca Mercas, Pamela Franco, Annette Gäbelein, Sabrina Heynckes, Dietmar Pfeifer, Stefan Weber, Irina Mader, Oliver Schnell
The purpose of this study was to map the landscape of metabolic-transcriptional alterations in glioblastoma multiforme. Omic-datasets were acquired by metabolic profiling (1D-NMR spectroscopy n=33 Patient) and transcriptomic profiling (n=48 Patients). Both datasets were analyzed by integrative network modeling. The computed model concluded in four different metabolic-transcriptomic signatures containing: oligodendrocytic differentiation, cell-cycle functions, immune response and hypoxia. These clusters were found being distinguished by individual metabolism and distinct transcriptional programs...
July 25, 2017: Oncotarget
Melek K Eryılmaz, Hasan Mutlu, Fatma Yalçin Müsri, Derya K Salim, Gökhan Tazegül, Hasan Ş Coşkun
Bevacizumab is a humanized monoclonal antibody targeting vascular endothelial growth factor, and it has been shown to improve progression-free survival in patients with recurrent glioblastome multiforme when administered as second-line therapy. However, it has been associated with serious and fatal hemorrhagic events. Here, we present a 68-year-old male who developed severe periocular bleeding while on bevacizumab for recurrent temozolamide-resistant glioblastome multiforme.
April 22, 2016: Journal of Oncology Pharmacy Practice
Victor Kuete, Louis P Sandjo, Armelle T Mbaveng, Jackson A Seukep, Bonaventure T Ngadjui, Thomas Efferth
BACKGROUND: Malignacies are still a major public concern worldwide and despite the intensive search for new chemotherapeutic agents, treatment still remains a challenging issue. This work was designed to assess the cytotoxicity of six selected Cameroonian medicinal plants, including Nauclea pobeguinii and its constituents 3-acetoxy-11-oxo-urs-12-ene (1), p-coumaric acid (2), citric acid trimethyl ester (3), resveratrol (4), resveratrol β- D -glucopyranoside (5) and strictosamide (6), against 8 drug-sensitive and multidrug-resistant (MDR) cancer cell lines...
September 4, 2015: BMC Complementary and Alternative Medicine
Simone dos S Grecco, Euder Glendes A Martins, Natália Girola, Carlos R de Figueiredo, Alisson L Matsuo, Marisi G Soares, Bruno de C Bertoldo, Patricia Sartorelli, João Henrique G Lago
CONTEXT: Nectandra (Lauraceae) species have been used in folk medicine as an antidiarrheal, analgesic, antifungal, etc., and have many pharmacological proprieties. OBJECTIVE: Investigation of the chemical composition and cytotoxicity of essential oil from Nectandra leucantha Nees & Mart. leaves. This is the first study involving N. leucantha reported in the literature. MATERIAL AND METHODS: The essential oil of N. leucantha leaves was obtained by hydrodistillation...
January 2015: Pharmaceutical Biology
Alexander T Falk, Coralie Moncharmont, Matthieu Guilbert, Jean-Baptiste Guy, Gersende Alphonse, Jane-Chloé Trone, Romain Rivoirard, Marion Gilormini, Robert-Alain Toillon, Claire Rodriguez-Lafrasse, Nicolas Magné
Glioblastoma multiform is the most common and aggressive brain tumor with a worse prognostic. Ionizing radiation is a cornerstone in the treatment of glioblastome with chemo-radiation association being the actual standard. As a paradoxal effect, it has been suggested that radiotherapy could have a deleterious effect on local recurrence of cancer. In vivo studies have studied the effect of radiotherapy on biological modification and pathogenous effect of cancer cells. It seems that ionizing radiations with photon could activate oncogenic pathways in glioblastoma cell lines...
September 2014: Bulletin du Cancer
Erica Biolcati P da Silva, Alisson L Matsuo, Carlos R Figueiredo, Mariana H Chaves, Patricia Sartorelli, João Henrique G Lago
This work reports the chemical composition and cytotoxic evaluation of the essential oils from three different samples of the leaves of Porcelia macrocarpa R. E. Fries (Annonaceae). The crude oils, obtained by hydrodistillation procedures, were chemically analyzed by GC/MS. The obtained data indicated the predominance of sesquiterpenes (89.8 +/- 0.7%), the main compounds being germacrene D (47 +/-+/- 1%) and bicyclogermacrene (37 +/- 1%). These oils also contained the monoterpene verbanyl acetate (0.5 +/- 0...
February 2013: Natural Product Communications
Mark Rickhey, Zdenek Morávek, Christoph Eilles, Oliver Koelbl, Ludwig Bogner
PURPOSE: To investigate the potential of (18)F-fluoroethyltyrosine-positron emission tomography-((18)F-FET-PET-)based dose painting by numbers with protons. MATERIAL AND METHODS: Due to its high specificity to brain tumor cells, FET has a high potential to serve as a target for dose painting by numbers. Biological image-based dose painting might lead to an inhomogeneous dose prescription. For precise treatment planning of such a prescribed dose, an intensity-modulated radiotherapy (IMRT) algorithm including a Monte Carlo dose-calculation algorithm for spot-scanning protons was used...
June 2010: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
Xuan Zhou, Yu Ren, Lei Han, Mei Mei, Peng Xu, Chun-Zhi Zhang, Guang-Xiu Wang, Zhi-Fan Jia, Pei-Yu Pu, Chun-Sheng Kang
Activation of the AKT (serine-threonine kinase) pathway is a common feature in glioblastoma cells. Downstream factors of the AKT pathway are involved in cell proliferation, apoptosis, cellular migration and angiogenesis. Micro-RNAs (miRNAs) are highly conserved small non-coding RNAs that block targeted mRNA expression at the post-transcriptional level. The aim of this study was to investigate the role of the AKT pathway in regulating miRNA. The changes of miRNA expression profile in human glioblastome U251 cells after AKT small interfering RNA transfection were examined by a microarray, and confirmed by Northern blotting...
March 2010: International Journal of Oncology
A Bekar, H Bilgin, G Korfali, E Korfali, H Kocaeli, O Taskapiğlu
INTRODUCTION: Awake craniotomy permits the continuous assessment of intraoperative neurological functions. In addition, stereotactic laser guidance aids in performing minimally invasive procedures related to the radical resection of lesions located in eloquent and non-eloquent brain regions. METHODS: Between May 2000 and October 2006, 117 consecutive patients with various intracranial tumoral lesions underwent 141 resection procedures. The eloquent areas were determined with the aid of anatomic landmarks and/or functional MRI (fMRI) examinations...
August 2009: Minimally Invasive Neurosurgery: MIN
Kiyoshi Nakamatsu, Minoru Suzuki, Yasumasa Nishimura, Shuichi Kanamori, Ryuta Koike, Toru Shibata, Naoya Shintani, Masahiko Okumura, Kaoru Okajima, Fumiharu Akai
BACKGROUND: The aim of this article is to report the treatment outcomes, toxicities, and dosimetric feasibility of our simultaneous-boost intensity-modulated radiotherapy (SIB-IMRT) protocol. METHODS: Thirteen patients with malignant gliomas treated between December 2000 and September 2004 were enrolled in this study. Two planning target volumes (PTVs) were defined in the present study. Our IMRT regimen delivered 70 Gy/28 fractions (fr)/daily; 2.5 Gy to the gross tumor volume (GTV) with a 0...
February 2008: International Journal of Clinical Oncology
M Lévêque, C Dimitriu, T Gustin, J Jamart, C Gilliard, M W Bojanowski
OBJECTIVE: Internet has become the first place where patients go to when seeking information about their disease. Little is known about the type and the quality of the medical information available on French-speaking websites, especially in the field of neuro-oncology. The purpose of this study was to evaluate the quality of these sites. MATERIALS AND METHODS: We entered six key words "glioblastome", "méningiome", "métastase cérébrale", "neurinome de l'acoustique", "adénome à prolactine" and "lymphome primitif cérébral" into 2 different search engines and, for each key word, the first fifty websites were reviewed using the tool "DISCERN", and with the help of two neuro-oncologists, we rated their content in terms of quality and comprehension...
November 2007: Neuro-Chirurgie
Paola D'Avenia, Alessandro Porrello, Marco Berardo, Marco D' Angelo, Silvia Soddu, Giorgio Arcangeli, Ada Sacchi, Gabriella D'Orazi
Tp53 is frequently mutated or inactivated in glioblastomas. Due to the impairment of p53 activity, glioblastomas show a high degree of radioresistance. In an attempt to convert the radioresistant phenotype to a more radiosensitive one, we evaluated the efficacy of the combination of Adp53 gene transfer and X-ray irradiation. The combination of Adp53, at low multiplicity in order to mimic the low in vivo efficiency of virus-mediated gene delivery, with X-ray irradiation resulted in a marked decrease of glioblastoms cell survival...
January 8, 2006: Cancer Letters
W Lux, H-G Klobeck, P B Daniel, M Costa, R L Medcalf, W-D Schleuning
Besides its well-established role in wound healing and fibrinolysis, tissue-type plasminogen activator (t-PA) has been shown to contribute to cognitive processes and memory formation within the central nervous system, and to promote glutamate receptor-mediated excitotoxicity. The t-PA gene is expressed and regulated in neuronal cells but the regulatory transcriptional processes directing this expression are still poorly characterized. We have used DNase I-hypersensitivity mapping and in vivo foot printing to identify putative regulatory elements and transcription factor binding sites in two human neuroblastomal (KELLY and SK-N-SH) and one human glioblastomal (SNB-19) cell lines...
May 2005: Journal of Thrombosis and Haemostasis: JTH
Delphine Cuchet, René Ferrera, Patrick Lomonte, Alberto L Epstein
BACKGROUND: The identification of novel proteins displaying cytostatic and/or cytotoxic actions that could eventually be used for gene therapy is a major issue in cancer research. Data from the literature suggested that the immediate-early ICP0 protein from herpes simplex virus type 1 (HSV-1) could fulfill these properties as it had been observed that this protein is involved in arrest of cell growth at the G1/S and G2/M phases of the cell cycle and that deletion of ICP0 from HSV-1 or HSV-1-recombinant vectors significantly reduced their cytotoxicity...
September 2005: Journal of Gene Medicine
No abstract text is available yet for this article.
September 1954: Monatsschrift Für Psychiatrie und Neurologie
J-F Mineo, I Quintin-Roue, B Lucas, V Buburusan, G Besson
Glioblastoma multiform is one of the most devastating primary tumors in neurooncology. We analyzed prognosis factors in patients with grade IV glioblastoma treated between 1993 and 1997. The 22 long-term survival patients (survival over 26 months) were extracted from our 30 years archives and the 2 populations are compared. The incidence was 2.6/100,000h/year, 62% male and 38% female, mean age 59 years, mean survival 12 months, median survival time 9 months. Multivariate analysis showed that younger age, surgical treatment and radiotherapy were all dependent prognosis factors for better survival...
December 2002: Neuro-Chirurgie
A Cabaravdić-Henda
In order to improve the quality of life and its duration, beside surgical operation with a patient with brain cancer, chemotherapy alone or in combination with radiotherapy may be applied in some cases. There are different protocols of chemotherapeutics (anticarcinomatous drugs) which are applied in treatment of some sorts carcinoma. The success of the therapy depends on the type and stage of the carcinoma, condition of patient well as of anticarcinomatous characteristics of the drug. Performed studies indicated that the life of the patients with glioblastom and astrocitom was prolonged through the application of carmustine or lomustine protocol of chemotherapy after x-rays...
2000: Medicinski Arhiv
G Boudin, B Pépin, J Mikol, M Haguenau, J C Vernant
Transient global amnesia occured three months previously to a tumoral Korsakoff's syndrome. Neuropathologic studies discovered a polymorph glioblastom strictly localized to posterior limbic system. The interest of topography and associated degenerations is pointed out.
March 1975: Revue Neurologique
A Zimmermann, M Schachner
The antigenic cell surface component NS-5 (nervous system antigen-5) is recognized by antiserum raised in C3H.SW/Sn mice against cerebellum of 4-day-old C57BL/6J mice. When analyzed in the cytotoxicity test the antiserum detects a cell surface antigen or set of antigens present not only an cerebellum but also other parts of the central nervous system, including retina, as well as on mature spermatozoa and to a lesser degree on kidney. All other non-neural tissues tested, liver, splee, thymocytes, muscle, testis, adrenal gland and epidermis do not express detectable amounts of the antigen...
October 15, 1976: Brain Research
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