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JOURNAL ARTICLE
Kirsten R Müller-Vahl, Anna Pisarenko, Carolin Fremer, Martina Haas, Ewgeni Jakubovski, Natalia Szejko
BACKGROUND: Comorbid functional tic-like behaviors (FTB) have been described only rarely in patients with Tourette syndrome (TS). OBJECTIVES: We present the first large sample of patients suffering from TS and FTB to raise awareness of this clinical presentation and to guide how to differentiate one from the other. METHODS: We analyzed clinical data of 71 patients (n = 27 [38.0%] female, mean age: 21.5, range: 11-55) with TS + FTB...
March 2024: Movement Disorders Clinical Practice
#22
JOURNAL ARTICLE
Natalia Szejko, Julian Fletcher, Davide Martino, Tamara Pringsheim
BACKGROUND: Premonitory urges (PU) are well described in primary tics, but their frequency and intensity in functional tic-like behaviors (FTLB) are unclear. OBJECTIVE: To study the experience of PU in patients with FTLB. METHODS: We compared the results of the premonitory urge for tics scale (PUTS) in adults with tics and FTLB in the University of Calgary Adult Tic Registry. RESULTS: We included 83 patients with tics and 40 with FTLB...
March 2024: Movement Disorders Clinical Practice
#23
JOURNAL ARTICLE
Time is ticking for TikTok tics: A retrospective follow-up study in the post-COVID-19 isolation era.
Kinga K Tomczak, Jennifer Worhach, Michael Rich, Olivia Swearingen Ludolph, Susan Eppling, Georgios Sideridis, Tamar C Katz
INTRODUCTION: During the COVID-19 pandemic, an influx of adolescents presented worldwide with acute onset of functional tic-like behaviors (FTLBs). Our goal was to evaluate psychosocial factors around onset, to elucidate outcomes after pandemic isolation protocols were lifted, and to examine therapy and medication management. METHODS: A retrospective review was performed of 56 patients ages 10-18 years with new-onset FTLBs seen at Boston Children's Hospital beginning in March 2020...
March 2024: Brain and Behavior
#24
JOURNAL ARTICLE
Yatong Zhang, Qianfang Fu, Hui Liu, Shuyi Zhao, Ping Rong
OBJECTIVES: To explore the rules of acupoint selection and compatibility of acupuncture for Tourette syndrome(TS) in children. METHODS: The relevant literature regarding acupuncture for Tourette syndrome in children included in CNKI, Wanfang, VIP, SinoMed, PubMed, Web of Science and Cochrane Library from the establishment of the database to March 31st, 2023 was retrieved.The information of acupuncture prescription, syndrome type, meridian affinity was extracted to set up database...
March 12, 2024: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
#25
Meghan Van Zandt, Deirdre Flanagan, Christopher Pittenger
Dysfunction of the cortico-basal circuitry - including its primary input nucleus, the striatum - contributes to neuropsychiatric disorders, including autism and Tourette Syndrome (TS). These conditions show marked sexual dimorphism, occurring more often in males than in females. Regulatory interneurons, including cholinergic interneurons (CINs) and parvalbumin-expressing GABAergic fast spiking interneurons (FSIs), are implicated in human neuropsychiatric disorders such as TS, and ablation of these interneurons produces relevant behavioral pathology in male mice, but not in females...
March 3, 2024: bioRxiv
#26
Yifan Wang, Liana Fasching, Feinan Wu, Anita Huttner, Sabina Berretta, Rosalinda Roberts, James F Leckman, Alexej Abyzov, Flora M Vaccarino
Tourette syndrome (TS) is a disorder of high-order integration of sensory, motor, and cognitive functions afflicting as many as 1 in 150 children and characterized by motor hyperactivity and tics. Despite high familial recurrence rates, a few risk genes and no biomarkers have emerged as causative or predisposing factors. The syndrome is believed to originate in basal ganglia, where patterns of motor programs are encoded. Postmortem immunocytochemical analyses of brains with severe TS revealed decreases in cholinergic, fast-spiking parvalbumin, and somatostatin interneurons within the striatum (caudate and putamen nuclei)...
February 28, 2024: bioRxiv
#27
REVIEW
José Fidel Baizabal-Carvallo, Andrea E Cavanna, Joseph Jankovic
Tourette syndrome (TS) is a complex neurodevelopmental disorder characterized by the presence of tics, frequently accompanied by a variety of neuropsychiatric comorbidities. A subset of patients with TS present with severe and disabling symptoms, requiring prompt therapeutic intervention. Some of these manifestations may result in medical emergencies when severe motor or phonic tics lead to damage of anatomical structures closely related to the tic. Examples include myelopathy or radiculopathy following severe neck ("whiplash") jerks or a variety of self-inflicted injuries...
April 2024: Neuroscience and Biobehavioral Reviews
#28
JOURNAL ARTICLE
Valerie Swisher, Maya Tooker, Christine Qu, Helen J Burgess, Meredith E Coles, Shannon Bennett, John Piacentini, Christopher S Colwell, Emily J Ricketts
The present study examined rates of sleep disorders and sleep medication use, and predictors of sleep disturbance in children with persistent tic disorders (PTD). Sixty-three parents of children aged 10 to 17 years with PTDs completed an internet survey evaluating sleep patterns and clinical symptoms. Insomnia (19.4%), nightmares (16.1%), and bruxism (13.1%) were the most commonly reported lifetime sleep disorders. Fifty-two percent endorsed current sleep medication use. Higher ADHD severity, overall life impairment, and female sex predicted greater sleep disturbance...
2024: Children's Health Care: Journal of the Association for the Care of Children's Health
#29
JOURNAL ARTICLE
Kirsten R Müller-Vahl
Although an increasing number of patients suffering from mental illnesses self-medicate with cannabis , current knowledge about the efficacy and safety of cannabis -based medicine in psychiatry is still extremely limited. So far, no cannabis -based finished product has been approved for the treatment of a mental illness. There is increasing evidence that cannabinoids may improve symptoms in autism spectrum disorder (ASD), Tourette syndrome (TS), anxiety disorders, and post-traumatic stress disorder (PTSD). According to surveys, patients often use cannabinoids to improve mood, sleep, and symptoms of attention deficit/hyperactivity disorder (ADHD)...
March 1, 2024: Pharmacopsychiatry
#30
JOURNAL ARTICLE
Lindsay Berg, Tamara M Pringsheim, Mackenzie Lerario, Davide Martino
Functional tic-like behaviours (FTLB) are a female predominant functional neurological disorder that escalated in incidence during the SARS CoV2 pandemic. This study compared social and adaptive functioning, social media use, pandemic experiences, and psychiatric comorbidities between FTLB (n = 35), Tourette Syndrome (TS) (n = 22), and neurotypical (NT) (n = 25) participants ages 11 to 25 years. The psychiatric comorbidity burden for participants with FTLB was formidable, with frequencies ranging from 1...
March 1, 2024: Research on child and adolescent psychopathology
#31
JOURNAL ARTICLE
Christine A Conelea, Shannon Bennett, Michael Himle, Sara Hamilton, Carolyn Hunt, Diana Shineman, Carol Mathews, Matthew Capriotti
To establish a patient-centered agenda for research that will lead to effective, widespread availability, adoption, and utilization of evidence-based behavioral treatment of Tourette syndrome and other tic disorders (TDs), we planned and executed a multistage, collaborative "Treating Tourette Together" research planning project with researchers, clinicians, patients, families, and other interested parties. Priorities for future behavioral treatment research were solicited from these parties via anonymous community surveys, a 2-day research planning summit with 46 individuals representing key stakeholder groups, and community response to summit reports...
March 2024: Behavior Therapy
#32
JOURNAL ARTICLE
Mark A Liker, Terence D Sanger, Jennifer A MacLean, Jaya Nataraj, Enrique Arguelles, Mark Krieger, Aaron Robison, Joffre Olaya
Selection of targets for deep brain stimulation (DBS) has been based on clinical experience, but inconsistent and unpredictable outcomes have limited its use in patients with heterogeneous or rare disorders. In this large case series, a novel staged procedure for neurophysiological assessment from 8 to 12 temporary depth electrodes is used to select targets for neuromodulation that are tailored to each patient's functional needs. Thirty children and young adults underwent deep brain stimulation target evaluation with the new procedure: Stereotactic Awake Basal ganglia Electrophysiological Recording and Stimulation (SABERS)...
February 26, 2024: Journal of Child Neurology
#33
JOURNAL ARTICLE
Christelle Nilles, Davide Martino, Tamara Pringsheim
BACKGROUND AND PURPOSE: The aim was to test the specificity of phenomenological criteria for functional tic-like behaviours (FTLBs). The European Society for the Study of Tourette Syndrome (ESSTS) criteria for the diagnosis of FTLBs include three major criteria: age at symptom onset ≥12 years, rapid evolution of symptoms and specific phenomenology. METHODS: Children and adolescents with primary tic disorders have been included in a Registry in Calgary, Canada, since 2017...
February 23, 2024: European Journal of Neurology
#34
JOURNAL ARTICLE
Giulia Conte, Carola Costanza, Maria Novelli, Veronica Scarselli, Elena Arigliani, Francesca Valente, Valentina Baglioni, Arianna Terrinoni, Flavia Chiarotti, Francesco Cardona
BACKGROUND: Cognitive functions represent foundational factors for mental health and quality of life (QoL). In Tourette syndrome (TS), psychiatric comorbidities are common and have been inconsistently reported to affect the cognition and QoL of patients, while the role of tic disorder duration has not been yet explored. METHODS: To examine how comorbidities and TS duration may influence cognition and QoL, N = 80 children with TS (6-16 years) were evaluated using the Wechsler Intelligence Scale for Children (WISC-IV)...
February 9, 2024: Children
#35
JOURNAL ARTICLE
Hong-Hua Li, Xi-Fei Wang, Bing Wang, Fei-Yong Jia
Children with chronic tic disorders (CTD), including Tourette syndrome (TS), have significantly reduced serum 25-hydroxyvitamin D [25(OH)D]. While vitamin D3 supplementation (VDS) may reduce tic symptoms in these children, its mechanism is unclear. The study aim was to investigate the effects and mechanisms of vitamin D deficiency (VDD) and VDS on TS model behavior. Forty 5-week-old male Sprague-Dawley rats were randomly divided into (n = 10 each): control, TS model, TS model with VDD (TS + VDD), or TS model with VDS (TS + VDS; two intramuscular injections of 20,000 IU/200 g) groups...
February 23, 2024: European Child & Adolescent Psychiatry
#36
JOURNAL ARTICLE
Ancha Baranova, Qian Zhao, Hongbao Cao, Vikas Chandhoke, Fuquan Zhang
Previous studies have observed a significant comorbidity between Alzheimer's disease (AD) and some other neuropsychiatric disorders. However, the mechanistic connections between neuropsychiatric disorders and AD are not well understood. We conducted a Mendelian randomization analysis to appraise the potential influences of 18 neurodegenerative and neuropsychiatric disorders on AD. We found that four disorders are causally associated with increased risk for AD, including bipolar disorder (BD) (OR: 1.09), migraine (OR: 1...
February 23, 2024: Translational Psychiatry
#37
JOURNAL ARTICLE
Barbara Hollunder, Jill L Ostrem, Ilkem Aysu Sahin, Nanditha Rajamani, Simón Oxenford, Konstantin Butenko, Clemens Neudorfer, Pablo Reinhardt, Patricia Zvarova, Mircea Polosan, Harith Akram, Matteo Vissani, Chencheng Zhang, Bomin Sun, Pavel Navratil, Martin M Reich, Jens Volkmann, Fang-Cheng Yeh, Juan Carlos Baldermann, Till A Dembek, Veerle Visser-Vandewalle, Eduardo Joaquim Lopes Alho, Paulo Roberto Franceschini, Pranav Nanda, Carsten Finke, Andrea A Kühn, Darin D Dougherty, R Mark Richardson, Hagai Bergman, Mahlon R DeLong, Alberto Mazzoni, Luigi M Romito, Himanshu Tyagi, Ludvic Zrinzo, Eileen M Joyce, Stephan Chabardes, Philip A Starr, Ningfei Li, Andreas Horn
Frontal circuits play a critical role in motor, cognitive and affective processing, and their dysfunction may result in a variety of brain disorders. However, exactly which frontal domains mediate which (dys)functions remains largely elusive. We studied 534 deep brain stimulation electrodes implanted to treat four different brain disorders. By analyzing which connections were modulated for optimal therapeutic response across these disorders, we segregated the frontal cortex into circuits that had become dysfunctional in each of them...
February 22, 2024: Nature Neuroscience
#38
Yanlin Jiang, Yuan Li, Xi Chen, Rui Zhai, Yaqi Peng, Ran Tai, Congxiao Zhou, Junhong Wang
OBJECTIVE: This research aims to investigate whether peripheral biomarkers might differentiate individuals with Tourette syndrome (TS) from those without the condition. METHODS: A broad range of databases was searched through November 2022. This study employed a systematic literature review and subsequent meta-analysis of case-control studies that assessed the aberration of biomarkers of patients with TS and controls. RESULTS: A total of 81 studies were identified, out of which 60 met the eligibility criteria for inclusion in the meta-analysis...
2024: Frontiers in Neurology
#39
JOURNAL ARTICLE
Shu Wang, Shiying Fan, Yifei Gan, Yuan Zhang, Yuan Gao, Tao Xue, Hutao Xie, Ruoyu Ma, Quan Zhang, Baotian Zhao, Yanwen Wang, Guanyu Zhu, Anchao Yang, Yin Jiang, Fangang Meng, Jianguo Zhang
OBJECTIVES: To evaluate the efficacy and safety of combined deep brain stimulation (DBS) with capsulotomy for comorbid motor and psychiatric symptoms in patients with Tourette's syndrome (TS). METHODS: This retrospective cohort study consecutively enrolled TS patients with comorbid motor and psychiatric symptoms who were treated with combined DBS and anterior capsulotomy at our center. Longitudinal motor, psychiatric, and cognitive outcomes and quality of life were assessed...
February 7, 2024: Asian Journal of Psychiatry
#40
JOURNAL ARTICLE
Brenda Cabrera-Mendoza, Frank R Wendt, Gita A Pathak, Loic Yengo, Renato Polimanti
To investigate assortative mating (AM), participation bias and socioeconomic status (SES) with respect to the genetics of behavioural and psychiatric traits, we estimated AM signatures using gametic phase disequilibrium and within-spouses and within-siblings polygenic risk score correlation analyses, also performing a SES conditional analysis. The cross-method meta-analysis identified AM genetic signatures for multiple alcohol-related phenotypes, bipolar disorder, major depressive disorder, schizophrenia and Tourette syndrome...
February 16, 2024: Nature Human Behaviour
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