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Tourettes syndrome

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https://www.readbyqxmd.com/read/28102636/thalamic-deep-brain-stimulation-for-refractory-tourette-syndrome-clinical-evidence-for-increasing-disbalance-of-therapeutic-effects-and-side-effects-at-long-term-follow-up
#1
Anouk Y J M Smeets, Annelien A Duits, Albert F G Leentjens, Koen Schruers, Vivianne van Kranen-Mastenbroek, Veerle Visser-Vandewalle, Yasin Temel, Linda Ackermans
OBJECTIVE: Thalamic deep brain stimulation (DBS) is effective in reducing tics in patients with refractory Tourette syndrome at the short-term. Here, we report on the long-term outcome. MATERIALS AND METHODS: Seven patients underwent bilateral DBS between 2001 and 2008. The target was the centromedian nucleus, substantia periventricularis and nucleus ventro-oralis internus cross point of the thalamus. The effect on tics and side effects were evaluated with a variable follow-up duration of 12 to 78 months...
January 19, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28099872/assessment-of-gait-and-sensorimotor-deficits-in-the-d1ct-7-mouse-model-of-tourette-syndrome
#2
Stephen C Fowler, Laura J Mosher, Sean C Godar, Marco Bortolato
Tourette syndrome (TS) is a neurodevelopmental disorder characterized by multiple motor and phonic tics. While TS patients have been also shown to exhibit subtle abnormalities of sensorimotor integration and gait, animal models of this disorder are seldom tested for these functions. To fill this gap, we assessed gait and sensorimotor integration in the D1CT-7 mouse, one of the best-validated animal models of TS. D1CT-7 mice exhibit spontaneous tic-like manifestations, which, in line with the clinical phenomenology of TS, are markedly exacerbated by environmental stress...
January 15, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28099039/gilles-de-la-tourette-syndrome-depression-depressive-illness-and-correlates-in-a-child-and-adolescent-population
#3
Renata Rizzo, Mariangela Gulisano, Davide Martino, Mary May Robertson
OBJECTIVE: Gilles de la Tourette syndrome (GTS) and depression are both common disorders. It has been suggested that depression occurs in 13%-76% GTS patients. Despite this, there are few studies into the specific relationships and correlates between the two disorders. There is only some consensus as to the precise relationship between the two disorders. MATERIALS AND METHODS: We undertook the study to investigate the relationship between depressive symptomatology and the core clinical features of GTS in a well-characterized clinical population of youth with this disorder...
January 18, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28090804/choline-acetyltransferase-may-contribute-to-the-risk-of-tourette-syndrome-combination-of-family-based-analysis-and-case-control-study
#4
Xiuling Yang, Wenmiao Liu, Mingji Yi, Ru Zhang, Yinglei Xu, Zuzhou Huang, Shiguo Liu, Tang Li
OBJECTIVES: Twin and family analyses have revealed a genetic contribution to Tourette syndrome and postmortem studies have raised the intriguing possibility of a reduction in cholinergic interneuronsin TS patients. METHODS: We selected five tag SNPs (rs100824791, rs12264845, rs1880676, rs3793790 and rs3793798) of Choline Acetyltransferase (CHAT) from the Han Chinese population Hapmap database. Genotyping was conducted on 401 TS nuclear family trios and 405 control subjects...
January 16, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28074769/-neuroradiological-changes-by-suppression-of-tics
#5
Sara Bohn Larsen, Camilla Birgitte Sørensen, Liselotte Skov, Nanette Mol Debes
Tourette's syndrome is characterized by involuntary tics. First choice of treatment has been pharmacological, but recently, behavioural therapy teaching patients to suppress their tics has been introduced. Neuroimaging studies have shown an increased activity in the prefrontal cortex, temporal lobes and caudate nucleus, and a decreased activity in globus pallidus and putamen during inhibition of tics. The activity in the frontal lobes changes with age, probably caused by a lack of compensatory hypertrophy. In order to fully understand the mechanism behind behavioural therapy further studies are needed...
January 2, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28071825/systematic-review-of-severity-scales-and-screening-instruments-for-tics-critique-and-recommendations
#6
Davide Martino, Tamara M Pringsheim, Andrea E Cavanna, Carlo Colosimo, Andreas Hartmann, James F Leckman, Sheng Luo, Alexander Munchau, Christopher G Goetz, Glenn T Stebbins, Pablo Martinez-Martin
BACKGROUND: Several clinician, informant, and self-report instruments for tics and associated phenomena have been developed that differ in construct, comprehensiveness, and ease of administration. OBJECTIVE: A Movement Disorders Society subcommittee aimed to rate psychometric quality of severity and screening instruments for tics and related sensory phenomena. METHODS: Following the methodology adopted by previous Movement Disorders Society subcommittee papers, a review of severity and screening instruments for tics was completed, applying a classification as "recommended," "suggested," or "listed" to each instrument...
January 10, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28039814/specific-executive-control-impairments-in-tourette-syndrome-the-role-of-response-inhibition
#7
Asaf Yaniv, Noa Benaroya-Milshtein, Tamar Steinberg, Dafna Ruhrrman, Alan Apter, Michal Lavidor
BACKGROUND: Tourette syndrome (TS) is a childhood-onset disorder characterized by motor and vocal tics. While cognitive features of common comorbid conditions such as attention deficit hyperactive disorder and obsessive compulsive disorder have been widely investigated, the cognitive profile of TS patients remains to be precisely defined. In this regard, the executive functions system (EF) is of especial interest. AIMS: The aim of the study was to delineate the various components of executive processes in adult TS patients...
December 28, 2016: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28038439/revisiting-stigma-exposure-to-tourette-in-an-ordinary-setting-increases-stigmatization
#8
Menachem Ben-Ezra, Sharon Anavi-Goffer, Ella Arditi, Pazit Ron, Rachel Paryenta Atia, Yonat Rate, Krzysztof Kaniasty
Stigma toward people with mental disorders is frequently studied yet less is known about prejudice toward persons with tic disorders, especially sufferers of Gilles de la Tourette Syndrome (GTS). We examined stigmatizing attributions concerning a GTS patient in an online study with participants randomly assigned to one of two video clip conditions: the experimental group saw to a person with Tourette syndrome; the control group watched a nature scenic footage. Results revealed that participants in the experimental condition exhibited higher scores on a stigma questionnaire...
November 29, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/28032854/do-cannabinoids-have-a-role-to-play-in-tourette%C3%A2-s-syndrome
#9
Karen García, Gabriel Rada
It has been suggested that the use of cannabinoids might play a role in the treatment of Tourette’s syndrome, but there is no consensus. Searching in Epistemonikos database, which is maintained by screening multiple databases, we identified seven systematic reviews including two randomized trials addressing the question of this article. We extracted data, combined the evidence using meta-analysis and generated a summary of findings following the GRADE approach. We concluded it is not clear whether cannabinoids reduce tics in Tourette’s syndrome, and they are probably associated to frequent adverse effects...
December 9, 2016: Medwave
https://www.readbyqxmd.com/read/28018198/time-processing-and-motor-control-in-movement-disorders
#10
REVIEW
Laura Avanzino, Elisa Pelosin, Carmelo M Vicario, Giovanna Lagravinese, Giovanni Abbruzzese, Davide Martino
The subjective representation of "time" is critical for cognitive tasks but also for several motor activities. The neural network supporting motor timing comprises: lateral cerebellum, basal ganglia, sensorimotor and prefrontal cortical areas. Basal ganglia and associated cortical areas act as a hypothetical "internal clock" that beats the rhythm when the movement is internally generated. When timing information is processed to make predictions on the outcome of a subjective or externally perceived motor act, cerebellar processing and outflow pathways appear to be primarily involved...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28017555/a-preliminary-examination-of-self-concept-in-older-adolescents-and-young-adults-with-gilles-de-la-tourette-syndrome
#11
Paola R Silvestri, Flavia Chiarotti, Valentina Baglioni, Valeria Neri, Francesco Cardona, Andrea E Cavanna
INTRODUCTION: Gilles de la Tourette syndrome (GTS) is a childhood-onset neuropsychiatric disorder characterised by multiple tics and often associated with behavioural problems. Although there is evidence of significantly reduced self-esteem in children and adolescents with GTS, little is known about perceived self-concept and its clinical determinants at the transition age between adolescence and adulthood. We therefore set out to investigate self-concept in a clinical sample of young patients with GTS at this crucial age for personal development...
December 18, 2016: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/28012699/fear-of-fear-severe-tics-and-deep-brain-stimulation-in-childhood-tourette-syndrome-the-long-and-winding-road
#12
EDITORIAL
Tammy Hedderly
No abstract text is available yet for this article.
December 8, 2016: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/28010171/neural-correlates-of-prediction-violations-in-boys-with-tourette-syndrome-evidence-from-harmonic-expectancy
#13
Judith Buse, Christian Beste, Veit Roessner
OBJECTIVES: It has been suggested that Tourette syndrome (TS) might be associated with alterations of the attention system, but the nature of these alterations and the underlying neuroanatomical network remains elusive. We aimed at investigating the functional neuroanatomical modulators of attention allocation towards predictable vs. unpredictable stimuli in boys with TS. METHODS: Using fMRI, we ran a harmonic expectancy violation paradigm in 17 boys with TS and 23 matched healthy controls (HC)...
December 23, 2016: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28009622/procedural-consolidation-during-electroconvulsive-therapy-for-a-patient-with-severe-tourette-syndrome
#14
Rachel Katz, Elena Bukanova, Robert Ostroff
No abstract text is available yet for this article.
December 21, 2016: Journal of ECT
https://www.readbyqxmd.com/read/28007998/pathological-glutamatergic-neurotransmission-in-gilles-de-la-tourette-syndrome
#15
Ahmad Seif Kanaan, Sarah Gerasch, Isabel García-García, Leonie Lampe, André Pampel, Alfred Anwander, Jamie Near, Harald E Möller, Kirsten Müller-Vahl
Gilles de la Tourette syndrome is a hereditary, neuropsychiatric movement disorder with reported abnormalities in the neurotransmission of dopamine and γ-aminobutyric acid (GABA). Spatially focalized alterations in excitatory, inhibitory and modulatory neurochemical ratios within specific functional subdivisions of the basal ganglia, may lead to the expression of diverse motor and non-motor features as manifested in Gilles de la Tourette syndrome. Current treatment strategies are often unsatisfactory thus provoking the need for further elucidation of the underlying pathophysiology...
January 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/27974054/heritability-of-tic-disorders-a-twin-family-study
#16
N R Zilhão, M C Olthof, D J A Smit, D C Cath, L Ligthart, C A Mathews, K Delucchi, D I Boomsma, C V Dolan
BACKGROUND: Genetic-epidemiological studies that estimate the contributions of genetic factors to variation in tic symptoms are scarce. We estimated the extent to which genetic and environmental influences contribute to tics, employing various phenotypic definitions ranging between mild and severe symptomatology, in a large population-based adult twin-family sample. METHOD: In an extended twin-family design, we analysed lifetime tic data reported by adult mono- and dizygotic twins (n = 8323) and their family members (n = 7164; parents and siblings) from 7311 families in the Netherlands Twin Register...
December 15, 2016: Psychological Medicine
https://www.readbyqxmd.com/read/27942998/health-related-quality-of-life-anxiety-and-depression-in-parents-of-adolescents-with-gilles-de-la-tourette-syndrome-a-controlled-study
#17
Isabelle Jalenques, Candy Auclair, D Morand, G Legrand, Magali Marcheix, Clémentine Ramanoel, Andreas Hartmann, Ph Derost
Our objectives were to assess health-related quality of life (HRQoL), anxiety, depression of Gilles de la Tourette syndrome (GTS) adolescents' parents compared to controls; to assess GTS adolescents' HRQoL compared to controls; to investigate which parental and adolescent variables are associated with poorer parental HRQoL. The controlled study involved GTS outpatients and their parents, adolescent healthy controls matched for gender and age and their parents. Parents' HRQoL was assessed using SF-36 and WHOQOL-BREF; anxiety, depression using HADS...
December 9, 2016: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/27939782/what-makes-you-tic-translational-approaches-to-study-the-role-of-stress-and-contextual-triggers-in-tourette-syndrome
#18
REVIEW
Sean C Godar, Marco Bortolato
Tourette syndrome (TS) is a neurodevelopmental condition characterized by multiple, recurring motor and phonic tics. Rich empirical evidence shows that the severity of tics and associated manifestations is increased by several stressors and contextual triggers; however, the neurobiological mechanisms responsible for symptom exacerbation in TS remain poorly understood. This conceptual gap partially reflects the high phenotypic variability in tics, as well as the existing difficulties in operationalizing and standardizing stress and its effects in a clinical setting...
December 8, 2016: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/27932244/transcriptional-response-to-mitochondrial-protease-immp2l-knockdown-in-human-primary-astrocytes
#19
Akira Gokoolparsadh, Zhiming Fang, Nady Braidy, Peijie Lin, Christopher J Pardy, Valsamma Eapen, Raymond Clarke, Irina Voineagu
IMMP2L encodes the inner membrane peptidase subunit 2, a mitochondrial protease involved in cleaving the space-sorting signals of mitochondrial membrane proteins. IMMP2L has been implicated in Tourette syndrome, but how its dysfunction contributes to the neurodevelopmental phenotype remains unclear. Here we show that IMMP2L transcription requires Topoisomerase I in human primary astrocytes, and characterize the downstream effects of IMMP2L knockdown on gene expression. We demonstrate that IMMP2L knockdown leads to dysregulation of genes involved in central nervous system development...
January 22, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27920671/proceedings-of-the-fourth-annual-deep-brain-stimulation-think-tank-a-review-of-emerging-issues-and-technologies
#20
Wissam Deeb, James J Giordano, Peter J Rossi, Alon Y Mogilner, Aysegul Gunduz, Jack W Judy, Bryan T Klassen, Christopher R Butson, Craig Van Horne, Damiaan Deny, Darin D Dougherty, David Rowell, Greg A Gerhardt, Gwenn S Smith, Francisco A Ponce, Harrison C Walker, Helen M Bronte-Stewart, Helen S Mayberg, Howard J Chizeck, Jean-Philippe Langevin, Jens Volkmann, Jill L Ostrem, Jonathan B Shute, Joohi Jimenez-Shahed, Kelly D Foote, Aparna Wagle Shukla, Marvin A Rossi, Michael Oh, Michael Pourfar, Paul B Rosenberg, Peter A Silburn, Coralie de Hemptine, Philip A Starr, Timothy Denison, Umer Akbar, Warren M Grill, Michael S Okun
This paper provides an overview of current progress in the technological advances and the use of deep brain stimulation (DBS) to treat neurological and neuropsychiatric disorders, as presented by participants of the Fourth Annual DBS Think Tank, which was convened in March 2016 in conjunction with the Center for Movement Disorders and Neurorestoration at the University of Florida, Gainesveille FL, USA. The Think Tank discussions first focused on policy and advocacy in DBS research and clinical practice, formation of registries, and issues involving the use of DBS in the treatment of Tourette Syndrome...
2016: Frontiers in Integrative Neuroscience
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