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Tourettes syndrome

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https://www.readbyqxmd.com/read/29924402/altered-perception-action-binding-modulates-inhibitory-control-in-gilles-de-la-tourette-syndrome
#1
Vanessa Petruo, Benjamin Bodmer, Valerie C Brandt, Leoni Baumung, Veit Roessner, Alexander Münchau, Christian Beste
BACKGROUND: Gilles de la Tourette Syndrome (GTS) is a multifaceted neuropsychiatric developmental disorder with onset in childhood or adolescence and frequent remissions in early adulthood. A rather new emerging concept of this syndrome suggests that it is a disorder of purposeful actions, in which sensory processes and their relation to motor responses (actions) play a particularly important role. Thus, this syndrome might be conceived as a condition of altered 'perception-action binding'...
June 20, 2018: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/29917136/deep-brain-stimulation-for-tourette-syndrome
#2
Camilo E Peña, Amir H Faraji, R Mark Richardson
No abstract text is available yet for this article.
July 1, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29904585/recent-advances-in-deep-brain-stimulation-in-psychiatric-disorders
#3
REVIEW
Anne-Hélène Clair, William Haynes, Luc Mallet
Deep brain stimulation (DBS) has been offered to patients suffering of severe and resistant neuropsychiatric disorders like Obsessive Compulsive Disorder (OCD), Gilles de la Tourette Syndrome (TS) and Major Depression (MDD). Modulation of several targets within the cortico-striato-thalamo-cortical circuits can lead to a decrease of symptom severity in those patients. This review focuses on the recent clinical outcomes in DBS in psychiatric disorders. Studies on OCD and TS are now focusing on the long-term effects of DBS, with encouraging results regarding not only the decrease of symptoms, but also quality of life...
2018: F1000Research
https://www.readbyqxmd.com/read/29893437/social-adjustment-experiences-of-adolescents-with-tourette-syndrome
#4
Mei-Yin Lee, Huei-Shyong Wang, Chen-Jung Chen, Mei-Hua Lee
AIMS AND OBJECTIVES: To explore and describe the experience of social adjustment of adolescents with Tourette syndrome in Taiwan. BACKGROUND: Although Tourette syndrome is a non-life-threatening disease, the inherent difficulties in controlling tics and comorbidities can cause long-term physical and psychological issues, as well as social maladjustment among adolescents. Good social adjustment can promote mental health among adolescents. Currently, it is not clear how adolescents with Tourette syndrome can self-adjust and maintain harmonious social interaction with others...
June 12, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29890507/genome-wide-analysis-of-rare-copy-number-variations-in-alcohol-abuse-or-dependence
#5
Julio Rodríguez-López, Gerardo Flórez, Vanessa Blanco, César Pereiro, José Manuel Fernández, Emilio Fariñas, Valentín Estévez, Jesús Gómez-Trigo, Xaquín Gurriarán, Raquel Calvo, Pilar Sáiz, Fernando Lino Vázquez, Manuel Arrojo, Javier Costas
Genetics plays an important role in alcohol abuse/dependence. Its heritability has been estimated as 45-65%. Rare copy number variations (CNVs) have been confirmed as relevant genetic factors in other neuropsychiatric disorders, such as autism spectrum disorders, schizophrenia, epilepsy, or Tourette syndrome. In the present study, we analyzed the role of rare CNVs affecting exons of coding genes in a sample from Northwest Spain genotyped using the Illumina Infinium PsychArray Beadchip. After rigorous genotyping quality control procedure, 712 patients with alcohol abuse or dependence and 804 controls were used for CNV detection...
June 2, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29885862/efficacy-of-repetitive-transcranial-magnetic-stimulation-for-tourette-syndrome-a-systematic-review-and-meta-analysis
#6
Chih-Wei Hsu, Liang-Jen Wang, Pao-Yen Lin
BACKGROUND: While previous studies have investigated the effect of repetitive transcranial magnetic stimulation (rTMS) in treating Tourette syndrome (TS), the results remain inconclusive. OBJECTIVE: We aim to systematically review the existing literature related to the efficacy of rTMS in TS and synthesize the results through meta-analysis. METHODS: We searched for PubMed, Embase, Cochrane Library, and ClinicalTrials.gov databases without language restriction through January 1, 2018, and included randomized-controlled and open-label trials that assessed the treatment effect of rTMS for tic symptoms...
June 5, 2018: Brain Stimulation
https://www.readbyqxmd.com/read/29877753/attention-bias-for-social-threat-in-youth-with-tic-disorders-links-with-tic-severity-and-social-anxiety
#7
Victoria Pile, Sally Robinson, Marta Topor, Tammy Hedderly, Jennifer Y F Lau
Many individuals with Tourette syndrome and chronic tic disorders (TS/CTDs) report poor social functioning and comorbid social anxiety. Yet limited research has investigated the role of cognitive factors that highlight social threats in youth with TS/CTD, and whether these biases underlie tic severity and co-occurring social anxiety. This study examined whether selective attention to social threat is enhanced young people with TS/CTDs compared to healthy controls, and whether attention biases are associated with tic severity and social anxiety...
June 7, 2018: Child Neuropsychology: a Journal on Normal and Abnormal Development in Childhood and Adolescence
https://www.readbyqxmd.com/read/29874283/olfactory-functioning-in-adults-with-tourette-syndrome
#8
Martin Kronenbuerger, Patrizia Belenghi, Justus Ilgner, Jessica Freiherr, Thomas Hummel, Irene Neuner
Tourette syndrome is a chronic tic disorder characterized by motor and vocal tics. Comorbidities such as attention deficit hyperactivity disorder and obsessive compulsive disorder can be found. The overlap between neuroanatomical regions and neurotransmitter systems in the olfactory system and the pathophysiology of Tourette syndrome let us hypothesize altered olfactory performance in Tourette syndrome. The main objective of this study was to systematically assess olfactory functioning in subjects with Tourette syndrome and to compare it to healthy controls...
2018: PloS One
https://www.readbyqxmd.com/read/29846538/reply-social-communication-in-tourette-syndrome-a-glimpse-at-the-contribution-of-the-insula-and-the-prefrontal-cortex
#9
Roger L Albin
No abstract text is available yet for this article.
May 26, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29846510/social-communication-in-tourette-syndrome-a-glimpse-at-the-contribution-of-the-insula-and-the-prefrontal-cortex
#10
Carmelo M Vicario, Davide Martino
No abstract text is available yet for this article.
May 26, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29813161/association-of-tourette-syndrome-and-chronic-tic-disorders-with-objective-indicators-of-educational-attainment-a-population-based-sibling-comparison-study
#11
Ana Pérez-Vigil, Lorena Fernández de la Cruz, Gustaf Brander, Kayoko Isomura, Andreas Jangmo, Ralf Kuja-Halkola, Eva Hesselmark, Brian M D'Onofrio, Henrik Larsson, David Mataix-Cols
Importance: The influence of Tourette syndrome and chronic tic disorders on academic performance has not been objectively quantified. Objective: To investigate the association of Tourette syndrome and chronic tic disorders with objectively measured educational outcomes, adjusting for measured covariates and unmeasured factors shared between siblings and taking common psychiatric comorbidities into account. Design, Setting, and Participants: A population-based birth cohort consisting of all individuals born in Sweden from 1976 to 1998 was followed up until December 2013...
May 29, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29797064/dbs-in-pediatric-patients-institutional-experience
#12
Huseyin Canaz, Isik Karalok, Baris Topcular, Mert Agaoglu, Zuhal Yapici, Sabri Aydin
INTRODUCTION: DBS is initially used for treatment of essential tremor and Parkinson's disease in adults. In 1996, a child with severe life-threatening dystonia was offered DBS to the internal globus pallidus (GPi) with lasting efficacy at 20 years. Since that time, increasing number of children benefited from DBS. PATIENTS AND METHODS: We retrospectively evaluated our database of patients who underwent DBS from 2011 to 2017. All patients ≤ 17 years of age at the time of implantation of DBS were included in this series...
May 24, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29781408/gilles-de-la-tourette-syndrome-as-a-paradigmatic-neuropsychiatric-disorder
#13
Andrea E Cavanna
Gilles de la Tourette syndrome is a chronic and complex tic disorder accompanied by specific behavioral problems in the majority of patients. With its multifaceted interplay between motion and emotion, this condition is a paradigmatic example of the science and art of clinical neuropsychiatry. This review article encompasses the clinical phenomenology of motor and vocal tics and associated sensory experiences (premonitory urges), as well as the behavioral spectrum of the most common comorbidities, including obsessive-compulsive disorder, attention-deficit and hyperactivity disorder, affective symptoms, and impulsivity...
May 21, 2018: CNS Spectrums
https://www.readbyqxmd.com/read/29781133/inhibition-is-impaired-in-children-with-obsessive-compulsive-symptoms-but-not-in-those-with-tics
#14
Christian Mancini, Francesco Cardona, Valentina Baglioni, Sara Panunzi, Patrizia Pantano, Antonio Suppa, Giovanni Mirabella
BACKGROUND: Impaired inhibitory control is thought to be a core deficit in psychiatric disorders where patients exhibit problems with controlling urges. These problems include the urge to perform movements typical of Tourette syndrome and the urge to execute compulsive actions typical of obsessive-compulsive disorder. However, the picture emerging from studies that address this issue is controversial. Furthermore, most studies have only focused on reactive control (the ability of subjects to react to a stop signal), but not on proactive control (the ability of patients to shape their response strategies in anticipation of known task demands)...
May 21, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29763648/autism-spectrum-disorder-classification-diagnosis-and-therapy
#15
REVIEW
Samata R Sharma, Xenia Gonda, Frank I Tarazi
Autism Spectrum Disorder (ASD) refers to a group of neurodevelopmental disorders including autism, Asperger's syndrome (AS) and pervasive developmental disorder-not otherwise specified (PDD-NOS). The new diagnostic criteria of ASD focuses on two core domains: social communication impairment and restricted interests/repetitive behaviors. The prevalence of ASD has been steadily increasing over the past two decades, with current estimates reaching up to 1 in 36 children. Hereditary factors, parental history of psychiatric disorders, pre-term births, and fetal exposure to psychotropic drugs or insecticides have all been linked to higher risk of ASD...
May 12, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29758375/alterations-in-the-microstructure-of-white-matter-in-children-and-adolescents-with-tourette-syndrome-measured-using-tract-based-spatial-statistics-and-probabilistic-tractography
#16
Hilmar P Sigurdsson, Sophia E Pépés, Georgina M Jackson, Amelia Draper, Paul S Morgan, Stephen R Jackson
Tourette syndrome (TS) is a neurodevelopmental disorder characterised by repetitive and intermittent motor and vocal tics. TS is thought to reflect fronto-striatal dysfunction and the aetiology of the disorder has been linked to widespread alterations in the functional and structural integrity of the brain. The aim of this study was to assess white matter (WM) abnormalities in a large sample of young patients with TS in comparison to a sample of matched typically developing control individuals (CS) using diffusion MRI...
April 12, 2018: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29755921/a-comprehensive-review-of-tourette-syndrome-and-complementary-alternative-medicine
#17
REVIEW
Ashutosh Kumar, L Duda, G Mainali, S Asghar, D Byler
Purpose of Review: Tourette syndrome (TS) is a neuropsychiatric condition defined by both motor and phonic tics over a period of at least 1 year with the onset before 18 years of age. The purpose of this article is to review the use of complementary alternative medicine (CAM) in children and adults with Tourette syndrome with emphasis on recent research. Recent Findings: Most patients do not tell their physician about the use of CAM unless if specifically asked...
2018: Current Developmental Disorders Reports
https://www.readbyqxmd.com/read/29748952/disentangling-tourette-syndrome-heterogeneity-through-hierarchical-ascendant-clustering
#18
Elena Cravedi, Emmanuelle Deniau, Marianna Giannitelli, Hugues Pellerin, Virginie Czernecki, Tiphanie Priou, Jean Xavier, Angèle Consoli, Andreas Hartmann, David Cohen
AIM: To explore the heterogeneity of Tourette syndrome as part of a neurodevelopmental spectrum. METHOD: Using hierarchical ascendant clustering based on tic symptoms, developmental milestones, and neurodevelopmental comorbidities, we analyzed the heterogeneity of Tourette syndrome phenotypes in a sample of 174 children and adolescents with Tourette syndrome referred to a tertiary university clinic. RESULTS: The model yielded three distinct clusters characterized as follows...
May 10, 2018: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29746399/tourette-syndrome-clinical-spectrum-mechanisms-and-personalized-treatments
#19
Andreas Hartmann, Yulia Worbe
PURPOSE OF REVIEW: To describe recent advances regarding the disease spectrum in Tourette syndrome, offer new mechanistic insights into tic generation and provide clues for personalized treatments in this disorder. RECENT FINDINGS: Apart from tics, which define Tourette syndrome, comorbidities are the rule and not the exception. They significantly define clinical presentation, disease severity and quality of life. Recent studies have highlighted the importance of screening for depression, anxiety and autism spectrum disorders in Tourette syndrome...
May 8, 2018: Current Opinion in Neurology
https://www.readbyqxmd.com/read/29736078/deep-brain-stimulation-of-anteromedial-globus-pallidus-internus-for-severe-tourette-syndrome
#20
Paresh K Doshi, Raghvendra Ramdasi, Smita Thorve
Tourette syndrome (TS) is a complex disorder characterized by tics and is associated with behavioral problems. Although its intensity decreases in adolescence and adult life, in some cases it continues to remain severe and refractory to medical treatment. Deep brain stimulation has been offered as a treatment option in such cases. We report two cases of TS treated with of anteromedial globus pallidum internus. Both the cases had good postoperative control of tics and associated obsessive-compulsive behavior...
January 2018: Indian Journal of Psychiatry
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