keyword
MENU ▼
Read by QxMD icon Read
search

Tourettes syndrome

keyword
https://www.readbyqxmd.com/read/29053770/tourette-syndrome-a-disorder-of-the-social-decision-making-network
#1
Roger L Albin
Tourette syndrome is a common neurodevelopmental disorder defined by characteristic involuntary movements, tics, with both motor and phonic components. Tourette syndrome is usually conceptualized as a basal ganglia disorder, with an emphasis on striatal dysfunction. While considerable evidence is consistent with these concepts, imaging data suggest diffuse functional and structural abnormalities in Tourette syndrome brain. Tourette syndrome exhibits features that are difficult to explain solely based on basal ganglia circuit dysfunctions...
August 22, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29053637/progress-in-genetic-studies-of-tourette-s-syndrome
#2
REVIEW
Yanjie Qi, Yi Zheng, Zhanjiang Li, Lan Xiong
Tourette's Syndrome (TS) is a complex disorder characterized by repetitive, sudden, and involuntary movements or vocalizations, called tics. Tics usually appear in childhood, and their severity varies over time. In addition to frequent tics, people with TS are at risk for associated problems including attention deficit hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD), anxiety, depression, and problems with sleep. TS occurs in most populations and ethnic groups worldwide, and it is more common in males than in females...
October 20, 2017: Brain Sciences
https://www.readbyqxmd.com/read/29046136/phenotype-development-in-adolescents-with-tourette-syndrome-a-large-clinical-longitudinal-study
#3
Camilla Groth, Nanette Mol Debes, Liselotte Skov
Tourette syndrome (TS) is a neurodevelopmental disorder characterized by frequent comorbidities and a wide spectrum of phenotype presentations. This study aimed to describe the development of phenotypes in TS and tic-related impairment in a large longitudinal study of 226 children and adolescents followed up after 6 years. The participants were clinically examined to assess tic severity and impairment, obsessive compulsive disorder (OCD), and attention-deficit/hyperactivity disorder (ADHD). The development in phenotypes changed toward less comorbidity with 40% TS-only (no OCD or ADHD) (TS without OCD or ADHD) at baseline and 55% at follow-up...
November 2017: Journal of Child Neurology
https://www.readbyqxmd.com/read/29038076/editorial-on-special-issue-animal-models-of-tourette-syndrome
#4
EDITORIAL
Marco Bortolato, Giuseppe di Giovanni
No abstract text is available yet for this article.
October 13, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29018554/psychiatric-neurosurgery-in-the-21st-century-overview-and-the-growth-of-deep-brain-stimulation
#5
REVIEW
Kenneth Barrett
Ambulatory deep brain stimulation (DBS) became possible in the late 1980s and was initially used to treat people with movement disorders. Trials of DBS in people with treatment-resistant psychiatric disorder began in the late 1990s, initially focusing on obsessive-compulsive disorder, major depressive disorder and Tourette syndrome. Despite methodological issues, including small participant numbers and lack of consensus over brain targets, DBS is now being trialled in a wide range of psychiatric conditions...
October 2017: BJPsych Bulletin
https://www.readbyqxmd.com/read/29017141/premonitory-urges-and-tics-in-tourette-syndrome-computational-mechanisms-and-neural-correlates
#6
REVIEW
Vasco A Conceição, Ângelo Dias, Ana C Farinha, Tiago V Maia
Tourette syndrome is characterized by open motor behaviors - tics - but another crucial aspect of the disorder is the presence of premonitory urges: uncomfortable sensations that typically precede tics and are temporarily alleviated by tics. We review the evidence implicating the somatosensory cortices and the insula in premonitory urges and the motor cortico-basal ganglia-thalamo-cortical loop in tics. We consider how these regions interact during tic execution, suggesting that the insula plays an important role as a nexus linking the sensory and emotional character of premonitory urges with their translation into tics...
October 7, 2017: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/28993238/thalamo-insular-pathway-conveying-orofacial-muscle-proprioception-in-the-rat
#7
Fumihiko Sato, Yume Uemura, Chiharu Kanno, Yumi Tsutsumi, Akiko Tomita, Ayaka Oka, Takafumi Kato, Katsuro Uchino, Jumpei Murakami, Tahsinul Haque, Yoshihisa Tachibana, Atsushi Yoshida
Little is known about how proprioceptive signals arising from muscles reach to higher brain regions such as the cerebral cortex. We have recently shown that a particular thalamic region, the caudo-ventromedial edge (VPMcvm) of ventral posteromedial thalamic nucleus (VPM), conveys the proprioceptive signals from jaw-closing muscle spindles (JCMSs) in rats. In this study, we further addressed how the orofacial thalamic inputs from the JCMSs were transmitted from the thalamus (VPMcvm) to the cerebral cortex in rats...
October 6, 2017: Neuroscience
https://www.readbyqxmd.com/read/28966546/tic-treatment-goes-tech-a-review-of-tichelper-com
#8
Christine A Conelea, Brianna C M Wellen
TicHelper.com ("TicHelper") is an interactive online treatment program for youth with chronic tic disorders (CTDs) or Tourette Syndrome (TS) and their parents. It is based on Comprehensive Behavioral Intervention for Tics (CBIT), an individual, outpatient therapy protocol shown to effectively reduce tics in randomized controlled trials. The TicHelper website offers a user-friendly dashboard that is effective in making it easy to navigate through different treatment modules. Modules parallel core CBIT procedures and consist of interactive exercises, informational videos, and self-report ratings...
August 2017: Cognitive and Behavioral Practice
https://www.readbyqxmd.com/read/28965812/executive-control-development-in-tourette-syndrome-and-its-role-in-tic-reduction
#9
Asaf Yaniv, Noa Benaroya-Milshtein, Tamar Steinberg, Daphna Ruhrman, Alan Apter, Michal Lavidor
Tourette syndrome (TS) is a childhood-onset disorder characterized by motor and vocal tics. Recent findings point to a possible role of executive functions system development in the tic reduction observed with age. The goal of the present work was to track the development of executive functions system measured by well-established cognitive tasks and its correlation with diminished tic severity over time in order to understand the role of executive functions in the remission process observed in most adults. The first study followed 25 young TS patients, measuring their executive functions and clinical condition at three time- points...
September 18, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28964503/is-procedural-memory-enhanced-in-tourette-syndrome-evidence-from-a-sequence-learning-task
#10
Ádám Takács, Andrea Kóbor, Júlia Chezan, Noémi Éltető, Zsanett Tárnok, Dezso Nemeth, Michael T Ullman, Karolina Janacsek
Procedural memory, which is rooted in the basal ganglia, underlies the learning and processing of numerous automatized motor and cognitive skills, including in language. Not surprisingly, disorders with basal ganglia abnormalities have been found to show impairments of procedural memory. However, brain abnormalities could also lead to atypically enhanced function. Tourette syndrome (TS) is a candidate for enhanced procedural memory, given previous findings of enhanced TS processing of grammar, which likely depends on procedural memory...
September 9, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28960154/report-of-a-patient-undergoing-chronic-responsive-deep-brain-stimulation-for-tourette-syndrome-proof-of-concept
#11
Rene Molina, Michael S Okun, Jonathan B Shute, Enrico Opri, P Justin Rossi, Daniel Martinez-Ramirez, Kelly D Foote, Aysegul Gunduz
Deep brain stimulation (DBS) has emerged as a promising intervention for the treatment of select movement and neuropsychiatric disorders. Current DBS therapies deliver electrical stimulation continuously and are not designed to adapt to a patient's symptoms. Continuous DBS can lead to rapid battery depletion, which necessitates frequent surgery for battery replacement. Next-generation neurostimulation devices can monitor neural signals from implanted DBS leads, where stimulation can be delivered responsively, moving the field of neuromodulation away from continuous paradigms...
September 29, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28915150/tics-and-tourette-a-clinical-pathophysiological-and-etiological-review
#12
Russell C Dale
PURPOSE OF REVIEW: Describe developments in the etiological understanding of Tourette syndrome. RECENT FINDINGS: Tourette syndrome is a complex heterogenous clinical syndrome, which is not a unitary entity. Pathophysiological models describe gamma-aminobutyric acid-ergic-associated disinhibition of cortico-basal ganglia motor, sensory and limbic loops. MRI studies support basal ganglia volume loss, with additional white matter and cerebellar changes. Tourette syndrome cause likely involves multiple vulnerability genes and environmental factors...
September 14, 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/28912160/dopamine-d2-receptors-modulate-pyramidal-neurons-in-mouse-medial-prefrontal-cortex-through-a-stimulatory-g-protein-pathway
#13
Sarah E Robinson, Vikaas S Sohal
Dopaminergic modulation of prefrontal cortex (PFC) is thought to play key roles in many cognitive functions and to be disrupted in pathological conditions, such as schizophrenia. We have previously described a phenomenon whereby dopamine D2 receptor (D2R) activation elicits afterdepolarizations (ADPs) in subcortically projecting (SC) pyramidal neurons within L5 of the PFC. These D2R-induced ADPs only occur following synaptic input, which activates NMDARs, even when the delay between the synaptic input and ADPs is relatively long (e...
October 18, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28902066/latent-class-analysis-of-adhd-neurodevelopmental-and-mental-health-comorbidities
#14
Benjamin Zablotsky, Matthew D Bramlett, Susanna N Visser, Melissa L Danielson, Stephen J Blumberg
OBJECTIVE: Many children diagnosed with attention-deficit/hyperactivity disorder (ADHD) experience co-occurring neurodevelopmental and psychiatric disorders, and those who do often exhibit higher levels of impairment than children with ADHD alone. This study provides a latent class analysis (LCA) approach to categorizing children with ADHD into comorbidity groups, evaluating condition expression and treatment patterns in each group. METHODS: Parent-reported data from a large probability-based national sample of children diagnosed with ADHD (2014 National Survey of the Diagnosis and Treatment of ADHD and Tourette Syndrome) were used for an LCA to identify groups of children with similar groupings of neurodevelopmental and psychiatric comorbidities among children with current ADHD (n = 2495)...
September 8, 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28894408/deep-brain-stimulation-dbs-for-movement-disorders-an-experience-in-hospital-universiti-sains-malaysia-husm-involving-12-patients
#15
Lim Liang Hooi, Diana Noma Fitzrol, Senthil Kumar Rajapathy, Tan Yew Chin, Sanihah Abdul Halim, Regunath Kandasamy, Wan Mohd Nazaruddin Wan Hassan, Badrisyah Idris, Abdul Rahman Izaini Ghani, Zamzuri Idris, John Tharakan, Sarun Nunta-Aree, Jafri Malin Abdullah
Deep brain stimulation (DBS) was first introduced in 1987 to the developed world. As a developing country Malaysia begun its movement disorder program by doing ablation therapy using the Radionics system. Hospital Universiti Sains Malaysia a rural based teaching hospital had to take into consideration both health economics and outcomes in the area that it was providing neurosurgical care for when it initiated its Deep Brain Stimulation program. Most of the patients were from the low to medium social economic groups and could not afford payment for a DBS implant...
March 2017: Malaysian Journal of Medical Sciences: MJMS
https://www.readbyqxmd.com/read/28888943/melanin-concentrating-hormone-modulates-oxytocin-mediated-marble-burying
#16
Nayna M Sanathara, Celia Garau, Amal Alachkar, Lien Wang, Zhiwei Wang, Katsuhiko Nishimori, Xiangmin Xu, Olivier Civelli
Repetitive and perseverative behaviors are common features of a number of neuropsychiatric diseases such as Angelman's syndrome, Tourette's syndrome, obsessive-compulsive disorder, and autism spectrum disorders. The oxytocin system has been linked to the regulation of repetitive behavior in both animal models and humans, but many of its downstream targets have still to be found. We report that the melanin-concentrating hormone (MCH) system is a target of the oxytocin system in regulating one repetitive behavior, marble burying...
September 6, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28887904/thirty-first-annual-symposium-on-etiology-pathogenesis-and-treatment-of-parkinson-disease-and-other-movement-disorders-presented-by-the-parkinson-study-group-huntington-study-group-dystonia-study-group-tourette-syndrome-study-group-cooperative-ataxia-group
#17
https://www.readbyqxmd.com/read/28878322/altered-topology-of-structural-brain-networks-in-patients-with-gilles-de-la-tourette-syndrome
#18
E Schlemm, B Cheng, F Fischer, C Hilgetag, C Gerloff, G Thomalla
Gilles de la Tourette syndrome is a neurodevelopmental disorder characterized by tics. Abnormal neuronal circuits in a wide-spread structural and functional network involved in planning, execution and control of motor functions are thought to represent the underlying pathology. We therefore studied changes of structural brain networks in 13 adult GTS patients reconstructed by diffusion tensor imaging and probabilistic tractography. Structural connectivity and network topology were characterized by graph theoretical measures and compared to 13 age-matched controls...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28863370/cognitive-flexibility-and-its-electrophysiological-correlates-in-gilles-de-la-tourette-syndrome
#19
Florian Lange, Caroline Seer, Kirsten Müller-Vahl, Bruno Kopp
Motor symptoms in Gilles de la Tourette syndrome (GTS) have been related to changes in frontostriatal brain networks. These changes may also give rise to alterations in cognitive flexibility. However, conclusive evidence for altered cognitive flexibility in patients with GTS is still lacking. Here, we meta-analyzed data from 20 neuropsychological studies that investigated cognitive flexibility in GTS using the Wisconsin Card Sorting Test (WCST). Results revealed medium-sized GTS-related performance deficits, which were significantly modulated by age: Whilst being substantial in children and adolescents with GTS, WCST deficits seem to dissolve in adult patients with GTS...
August 18, 2017: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/28861008/case-of-secondary-tics-associated-with-olanzapine-in-an-adult
#20
Eric W Mills, Lindsay S Shaffer, Fernando S Goes, Akira Sawa, Frederick C Nucifora
Atypical antipsychotic medications, such as risperidone, aripiprazole, and olanzapine, have utility in treating motor tics, particularly in Tourette syndrome. In rare cases, atypical antipsychotic medications have been associated with adult-onset motor tics. Such adverse drug reactions have been documented in response to quetiapine, aripiprazole, and amisulpride. Here, we report, to our knowledge, the first case of adult-onset motor tics related to olanzapine administration.
2017: Frontiers in Psychiatry
keyword
keyword
641
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"