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Mild traumatic brain injury cerebral blood flow

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https://www.readbyqxmd.com/read/27834539/chronic-cerebrovascular-abnormalities-in-a-mouse-model-of-repetitive-mild-traumatic-brain-injury
#1
Cillian E Lynch, Gogce Crynen, Scott Ferguson, Benoit Mouzon, Daniel Paris, Joseph Ojo, Paige Leary, Fiona Crawford, Corbin Bachmeier
PRIMARY OBJECTIVE: To investigate the status of the cerebrovasculature following repetitive mild traumatic brain injury (r-mTBI). RESEARCH DESIGN: TBI is a risk factor for development of various neurodegenerative disorders. A common feature of neurodegenerative disease is cerebrovascular dysfunction which includes alterations in cerebral blood flow (CBF). TBI can result in transient reductions in CBF, with severe injuries often accompanied by varying degrees of vascular pathology post-mortem...
2016: Brain Injury: [BI]
https://www.readbyqxmd.com/read/27755938/arterial-spin-labeling-perfusion-of-the-brain-emerging-clinical-applications
#2
Sven Haller, Greg Zaharchuk, David L Thomas, Karl-Olof Lovblad, Frederik Barkhof, Xavier Golay
Arterial spin labeling (ASL) is a magnetic resonance (MR) imaging technique used to assess cerebral blood flow noninvasively by magnetically labeling inflowing blood. In this article, the main labeling techniques, notably pulsed and pseudocontinuous ASL, as well as emerging clinical applications will be reviewed. In dementia, the pattern of hypoperfusion on ASL images closely matches the established patterns of hypometabolism on fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography (PET) images due to the close coupling of perfusion and metabolism in the brain...
November 2016: Radiology
https://www.readbyqxmd.com/read/27582726/the-controlled-cortical-impact-model-applications-considerations-for-researchers-and-future-directions
#3
REVIEW
Nicole D Osier, C Edward Dixon
Controlled cortical impact (CCI) is a mechanical model of traumatic brain injury (TBI) that was developed nearly 30 years ago with the goal of creating a testing platform to determine the biomechanical properties of brain tissue exposed to direct mechanical deformation. Initially used to model TBIs produced by automotive crashes, the CCI model rapidly transformed into a standardized technique to study TBI mechanisms and evaluate therapies. CCI is most commonly produced using a device that rapidly accelerates a rod to impact the surgically exposed cortical dural surface...
2016: Frontiers in Neurology
https://www.readbyqxmd.com/read/27554429/cerebral-perfusion-changes-in-post-concussion-syndrome-a-prospective-controlled-cohort-study
#4
Karen M Barlow, Lorenzo D Marcil, Deborah Dewey, Helen L Carlson, Frank P MacMaster, Brian L Brooks, R Marc Lebel
The biology of post-concussive symptoms is unclear. Symptoms are often increased during activities, and have been linked to decreased cerebrovascular reactivity and perfusion. The aim of this study was to examine cerebral blood flow (CBF) in children with different clinical recovery patterns following mild traumatic brain injury (mTBI). This was a prospective controlled cohort study of children with mTBI (ages 8 to 18 years) who were symptomatic with post-concussive symptoms at one month post-injury (symptomatic, n = 27) and children who had recovered quickly (asymptomatic, n = 24)...
November 21, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27251042/chronic-repetitive-mild-traumatic-brain-injury-results-in-reduced-cerebral-blood-flow-axonal-injury-gliosis-and-increased-t-tau-and-tau-oligomers
#5
Joseph O Ojo, Benoit Mouzon, Moustafa Algamal, Paige Leary, Cillian Lynch, Laila Abdullah, James Evans, Michael Mullan, Corbin Bachmeier, William Stewart, Fiona Crawford
Exposure to repetitive mild traumatic brain injury (mTBI) is a risk factor for chronic traumatic encephalopathy, which is characterized by patchy deposition of hyperphosphorylated tau aggregates in neurons and astrocytes at the depths of cortical sulci. We developed an mTBI paradigm to explore effects of repetitive concussive-type injury over several months in mice with a human tau genetic background (hTau). Two injuries were induced in the hTau mice weekly over a period of 3 or 4 months and the effects were compared with those in noninjured sham animals...
July 2016: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/27224640/transcranial-doppler-to-predict-neurologic-outcome-after-mild-to-moderate-traumatic-brain-injury
#6
Pierre Bouzat, Luc Almeras, Pauline Manhes, Laurence Sanders, Albrice Levrat, Jean-Stephane David, Raphael Cinotti, Russel Chabanne, Aurélie Gloaguen, Xavier Bobbia, Sophie Thoret, Lydia Oujamaa, Jean-Luc Bosson, Jean-François Payen, Karim Asehnoune, Philippe Pes, Jean-Yves Lefrant, Sébastien Mirek, François Albasini, Caron Scrimgeour, Jean-Marc Thouret, Freddy Chartier, Marc Ginet
BACKGROUND: To assess the performance of transcranial Doppler (TCD) in predicting neurologic worsening after mild to moderate traumatic brain injury. METHODS: The authors conducted a prospective observational study across 17 sites. TCD was performed upon admission in 356 patients (Glasgow Coma Score [GCS], 9 to 15) with mild lesions on cerebral computed tomography scan. Normal TCD was defined as a pulsatility index of less than 1.25 and diastolic blood flow velocity higher than 25 cm/s in the two middle cerebral arteries...
August 2016: Anesthesiology
https://www.readbyqxmd.com/read/27208495/spatiotemporal-changes-in-blood-brain-barrier-permeability-cerebral-blood-flow-t2-and-diffusion-following-mild-traumatic-brain-injury
#7
Wei Li, Lora Watts, Justin Long, Wei Zhou, Qiang Shen, Zhao Jiang, Yunxia Li, Timothy Q Duong
The blood-brain barrier (BBB) can be impaired following traumatic brain injury (TBI), however the spatiotemporal dynamics of BBB leakage remain incompletely understood. In this study, we evaluated the spatiotemporal evolution of BBB permeability using dynamic contrast-enhanced MRI and measured the volume transfer coefficient (K(trans)), a quantitative measure of contrast agent leakage across the blood and extravascular compartment. Measurements were made in a controlled cortical impact (CCI) model of mild TBI in rats from 1h to 7 days following TBI...
September 1, 2016: Brain Research
https://www.readbyqxmd.com/read/27206865/relations-of-blood-pressure-and-head-injury-to-regional-cerebral-blood-flow
#8
Jason E Kisser, Allyssa J Allen, Leslie I Katzel, Carrington R Wendell, Eliot L Siegel, David Lefkowitz, Shari R Waldstein
Hypertension confers increased risk for cognitive decline, dementia, and cerebrovascular disease. These associations have been attributed, in part, to cerebral hypoperfusion. Here we posit that relations of higher blood pressure to lower levels of cerebral perfusion may be potentiated by a prior head injury. Participants were 87 community-dwelling older adults - 69% men, 90% white, mean age=66.9years, 27.6% with a history of mild traumatic brain injury (mTBI) defined as a loss of consciousness ≤30min resulting from an injury to the head, and free of major medical (other than hypertension), neurological or psychiatric comorbidities...
June 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27165907/correlation-between-cerebral-autoregulation-and-carbon-dioxide-reactivity-in-patients-with-traumatic-brain-injury
#9
Yi Zhang, Xiuyun Liu, Luzius Steiner, Peter Smielewski, Eli Feen, John D Pickard, Marek Czosnyka
OBJECTIVE: Cerebral blood flow autoregulation is commonly impaired in patients with traumatic brain injury (TBI). This study was to investigate correlations between cerebral autoregulation and CO2 reactivity in patients with TBI during transient mild hypocapnia. METHODS: Patients with TBI who were on mechanical ventilation were hyperventilated for approximately 60 min. Indices of autoregulation, based on a model of the relationship between arterial blood pressure and blood flow velocity (FV) (ARIabp) and, separately, between cerebral perfusion pressure and FV (ARIcpp), were calculated...
2016: Acta Neurochirurgica. Supplement
https://www.readbyqxmd.com/read/27073378/pulsed-arterial-spin-labeling-effectively-and-dynamically-observes-changes-in-cerebral-blood-flow-after-mild-traumatic-brain-injury
#10
Shu-Ping Peng, Yi-Ning Li, Jun Liu, Zhi-Yuan Wang, Zi-Shu Zhang, Shun-Ke Zhou, Fang-Xu Tao, Zhi-Xue Zhang
Cerebral blood flow is strongly associated with brain function, and is the main symptom and diagnostic basis for a variety of encephalopathies. However, changes in cerebral blood flow after mild traumatic brain injury remain poorly understood. This study sought to observe changes in cerebral blood flow in different regions after mild traumatic brain injury using pulsed arterial spin labeling. Our results demonstrate maximal cerebral blood flow in gray matter and minimal in the white matter of patients with mild traumatic brain injury...
February 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/27013987/facilitating-mitochondrial-calcium-uptake-improves-activation-induced-cerebral-blood-flow-and-behavior-after-mtbi
#11
Madhuvika Murugan, Vijayalakshmi Santhakumar, Sridhar S Kannurpatti
Mild to moderate traumatic brain injury (mTBI) leads to secondary neuronal loss via excitotoxic mechanisms, including mitochondrial Ca(2+) overload. However, in the surviving cellular population, mitochondrial Ca(2+) influx, and oxidative metabolism are diminished leading to suboptimal neuronal circuit activity and poor prognosis. Hence we tested the impact of boosting neuronal electrical activity and oxidative metabolism by facilitating mitochondrial Ca(2+) uptake in a rat model of mTBI. In developing rats (P25-P26) sustaining an mTBI, we demonstrate post-traumatic changes in cerebral blood flow (CBF) in the sensorimotor cortex in response to whisker stimulation compared to sham using functional Laser Doppler Imaging (fLDI) at adulthood (P67-P73)...
2016: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/26940914/non-invasive-monitoring-of-intracranial-pressure-using-transcranial-doppler-ultrasonography-is-it-possible
#12
Danilo Cardim, C Robba, M Bohdanowicz, J Donnelly, B Cabella, X Liu, M Cabeleira, P Smielewski, B Schmidt, M Czosnyka
Although intracranial pressure (ICP) is essential to guide management of patients suffering from acute brain diseases, this signal is often neglected outside the neurocritical care environment. This is mainly attributed to the intrinsic risks of the available invasive techniques, which have prevented ICP monitoring in many conditions affecting the intracranial homeostasis, from mild traumatic brain injury to liver encephalopathy. In such scenario, methods for non-invasive monitoring of ICP (nICP) could improve clinical management of these conditions...
December 2016: Neurocritical Care
https://www.readbyqxmd.com/read/26871696/arterial-spin-labeling-perfusion-study-in-the-patients-with-subacute-mild-traumatic-brain-injury
#13
Che-Ming Lin, Ying-Chi Tseng, Hui-Ling Hsu, Chi-Jen Chen, David Yen-Ting Chen, Feng-Xian Yan, Wen-Ta Chiu
BACKGROUND: This study uses a MRI technique, three-dimension pulse continuous arterial spin labeling (3D-PCASL), to measure the patient's cerebral blood flow (CBF) at the subacute stage of mild traumatic brain injury (MTBI) in order to analyze the relationship between cerebral blood flow and neurocognitive deficits. OBJECTIVE: To provide the relationship between cortical CBF and neuropsychological dysfunction for the subacute MTBI patients. METHODS: After MTBI, perfusion MR imaging technique (3D-PCASL) measures the CBF of MTBI patients (n = 23) within 1 month and that of normal controls (n = 22) to determine the quantity and location of perfusion defect...
2016: PloS One
https://www.readbyqxmd.com/read/26489739/thoracic-shock-wave-injury-causes-behavioral-abnormalities-in-mice
#14
Hiromi Miyazaki, Hiroki Miyawaki, Yasushi Satoh, Takami Saiki, Satoko Kawauchi, Shunichi Sato, Daizoh Saitoh
BACKGROUND: Mild traumatic brain injury (mTBI) is caused by complex mechanisms of systemic, local and cerebral responses to blast exposure. However, the molecular mechanisms of cognitive impairment after exposure to blast waves are not clearly known. We tested the hypothesis that thoracic injury induced functional and morphological impairment in the brain, leading to behavioral abnormalities. METHODS: Mice were exposed to laser-induced shock waves (LISWs) impacting the thorax and assessed for behavioral outcome at 7 and 28 days post injury...
December 2015: Acta Neurochirurgica
https://www.readbyqxmd.com/read/26241476/disruptions-in-resting-state-functional-connectivity-and-cerebral-blood-flow-in-mild-traumatic-brain-injury-patients
#15
Chandler Sours, Jiachen Zhuo, Steven Roys, Kathirkamanthan Shanmuganathan, Rao P Gullapalli
Mild traumatic brain injury (mTBI) is often occult to conventional imaging techniques. However, there is growing evidence that mTBI patients who lack evidence of structural intracranial injury may develop post-concussive syndrome (PCS). We investigated longitudinal alterations in resting state functional connectivity (rs-FC) in brain networks in a population of 28 patients compared to 28 matched control participants. Rs-FC and cerebral blood flow (CBF) within the nodes of the Default Mode Network (DMN) and Task Positive Network (TPN) were assessed at three time points including acute, sub-acute, and chronic stages following mTBI...
2015: PloS One
https://www.readbyqxmd.com/read/26181957/111%C3%A2-new-observations-in-cerebral-glucose-metabolism-following-traumatic-brain-injury-the-mystery-of-the-missing-glucose-246-studies-in-74-patients-and-comparison-to-normal-controls
#16
Joshua Robert Dusick, Thomas C Glenn, Paul M Vespa, Neil A Martin
INTRODUCTION: Previous studies have demonstrated a profound dysfunction of cerebral metabolism following traumatic brain injury (TBI). Despite overall depression of cerebral metabolism, the cerebral metabolic rate (CMR) of oxygen is depressed out of proportion to the mildly reduced CMRglucose. This mismatch has raised the question, where does the missing glucose go if it is not metabolized oxidatively? We have previously demonstrated that an increased proportion of glucose is shunted through the pentose phosphate pathway prompting us to further investigate the total percentage of glucose metabolized by alternative pathways (the "missing glucose") in an attempt to understand the full milieu of altered or dysfunctional metabolism in the injured brain...
August 2015: Neurosurgery
https://www.readbyqxmd.com/read/26104285/the-effects-of-perturbed-cerebral-blood-flow-and-cerebrovascular-reactivity-on-structural-mri-and-behavioral-readouts-in-mild-traumatic-brain-injury
#17
Justin A Long, Lora T Watts, Wei Li, Qiang Shen, Eric R Muir, Shiliang Huang, Robert C Boggs, Abhinav Suri, Timothy Q Duong
This study investigated the effects of perturbed cerebral blood flow (CBF) and cerebrovascular reactivity (CR) on relaxation time constant (T2), apparent diffusion coefficient (ADC), fractional anisotropy (FA), and behavioral scores at 1 and 3 hours, 2, 7, and 14 days after traumatic brain injury (TBI) in rats. Open-skull TBI was induced over the left primary forelimb somatosensory cortex (N=8 and 3 sham). We found the abnormal areas of CBF and CR on days 0 and 2 were larger than those of the T2, ADC, and FA abnormalities...
November 2015: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/26018041/reasoning-training-in-veteran-and-civilian-traumatic-brain-injury-with-persistent-mild-impairment
#18
Asha Vas, Sandra Chapman, Sina Aslan, Jeffrey Spence, Molly Keebler, Gisella Rodriguez-Larrain, Barry Rodgers, Tiffani Jantz, David Martinez, Jelena Rakic, Daniel Krawczyk
Traumatic brain injury (TBI) is a chronic health condition. The prevalence of TBI, combined with limited advances in protocols to mitigate persistent TBI-related impairments in higher order cognition, present a significant challenge. In this randomised study (n = 60), we compared the benefits of Strategic Memory Advanced Reasoning Training (SMART, n = 31), a strategy-based programme shown to improve cognitive control, versus an active learning programme called Brain Health Workshop (BHW, n = 29) in individuals with TBI with persistent mild functional deficits...
August 2016: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/25714870/emerging-therapies-in-traumatic-brain-injury
#19
REVIEW
Patrick M Kochanek, Travis C Jackson, Nikki Miller Ferguson, Shaun W Carlson, Dennis W Simon, Erik C Brockman, Jing Ji, Hülya Bayır, Samuel M Poloyac, Amy K Wagner, Anthony E Kline, Philip E Empey, Robert S B Clark, Edwin K Jackson, C Edward Dixon
Despite decades of basic and clinical research, treatments to improve outcomes after traumatic brain injury (TBI) are limited. However, based on the recent recognition of the prevalence of mild TBI, and its potential link to neurodegenerative disease, many new and exciting secondary injury mechanisms have been identified and several new therapies are being evaluated targeting both classic and novel paradigms. This includes a robust increase in both preclinical and clinical investigations. Using a mechanism-based approach the authors define the targets and emerging therapies for TBI...
February 2015: Seminars in Neurology
https://www.readbyqxmd.com/read/25659079/cerebral-hemodynamic-changes-of-mild-traumatic-brain-injury-at-the-acute-stage
#20
Hardik Doshi, Natalie Wiseman, Jun Liu, Wentao Wang, Robert D Welch, Brian J O'Neil, Conor Zuk, Xiao Wang, Valerie Mika, Jerzy P Szaflarski, E Mark Haacke, Zhifeng Kou
Mild traumatic brain injury (mTBI) is a significant public health care burden in the United States. However, we lack a detailed understanding of the pathophysiology following mTBI and its relation to symptoms and recovery. With advanced magnetic resonance imaging (MRI), we can investigate brain perfusion and oxygenation in regions known to be implicated in symptoms, including cortical gray matter and subcortical structures. In this study, we assessed 14 mTBI patients and 18 controls with susceptibility weighted imaging and mapping (SWIM) for blood oxygenation quantification...
2015: PloS One
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