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Mean cerebral blood flow

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https://www.readbyqxmd.com/read/28722518/effects-of-pentoxifylline-on-hemodynamic-hemorheological-and-microcirculatory-parameters-in-young-shrs-during-arterial-hypertension-development
#1
Mark B Plotnikov, Oleg I Aliev, Alexander Y Shamanaev, Anastasia V Sidekhmenova, Yana Anfinogenova, Anna M Anishchenko, Tatiana I Fomina, Alexander M Arkhipov
The most common form of hypertension in young adults is isolated diastolic hypertension. Diastolic arterial pressure is determined by the total peripheral resistance and depends on both vascular hindrance and blood viscosity. The aim of our work was to study the efficiency of pentoxifylline (PTX) in young spontaneously hypertensive rats (SHRs) during the development of arterial hypertension. The effects of a treatment course with PTX (100 mg/kg/day p.o. for 6 weeks, from 5 to 11 weeks old) on the mean, systolic, and diastolic blood pressure (BP); stroke volume; cardiac output; total peripheral resistance (TPR); whole blood viscosity (BV); plasma viscosity; hematocrit; RBC aggregation and deformability; local cerebral blood flow (lCBF); and microvascularization of the visual cortex were studied in SHRs in comparison with control SHRs and Wistar Kyoto rats...
July 19, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28720742/-two-cases-of-ruptured-blood-blister-like-aneurysm-treated-with-x-ray-angiography-perfusion-xap-analysis
#2
Shoichi Tani, Hirotoshi Imamura, Katsunori Asai, Kampei Shimizu, Hidemitsu Adachi, So Tokunaga, Takayuki Funatsu, Mikiya Beppu, Keita Suzuki, Hiromasa Adachi, Tomohiro Okuda, Yuichi Matsui, Yasunori Yoshida, Shuhei Kawabata, Ryo Akiyama, Kazufumi Horiuchi, Nobuyuki Sakai
Two cases of ruptured blood blister-like internal carotid artery aneurysms for which low flow bypass was sufficient to attain successful treatment of trapping are reported. In the acute stage of rupture, it is troublesome to perform accurate examinations of tolerance to ischemia like balloon occlusion test(BOT)for estimating the required amount of bypass flow. In our cases, X-ray angiography perfusion(XAP)analysis was introduced, which could be performed in a couple dozen seconds without room-to-room transfer of patients, following the ordinary examination of diagnostic digital subtraction angiography...
July 2017: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/28720528/postoperative-dilatation-of-superficial-temporal-artery-associated-with-transient-neurological-symptoms-after-direct-bypass-surgery-for-moyamoya-angiopathy
#3
Daizo Ishii, Takahito Okazaki, Toshinori Matsushige, Katsuhiro Shinagawa, Nobuhiko Ichinose, Shigeyuki Sakamoto, Kaoru Kurisu
OBJECTIVE: In moyamoya angiopathy (MMA), transient neurological symptoms (TNS) are occasionally observed after superficial temporal artery (STA)-middle cerebral artery (MCA) direct bypass surgery. The purpose of this study was to investigate the correlation between TNS and postoperative MR images, as well as perform a perfusion study. METHODS: A total of 52 hemispheres in 33 consecutive patients with MMA were reviewed. TNS were defined as reversible neurological dysfunction without any apparent intracranial infarction or hemorrhage...
July 15, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28717076/increase-in-the-regional-cerebral-blood-flow-following-waon-therapy-in-patients-with-chronic-fatigue-syndrome-a-pilot-study
#4
Takao Munemoto, Yuji Soejima, Akinori Masuda, Yoshiaki Nakabeppu, Chuwa Tei
Objective Chronic fatigue syndrome (CFS) is a complex disorder, with no consensus on therapeutic options. However, Waon therapy has been reported to be an effective treatment. The purpose of this study was to evaluate changes in the cerebral blood flow (CBF) before and after Waon therapy in CFS patients and to investigate the correlation between such changes and the therapeutic efficacy of Waon therapy. Methods Eleven patients (2 men and 9 women, mean age 27 years old) diagnosed with CFS participated in the study...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28708726/measuring-cerebral-hypoperfusion-induced-by-hyperventilation-challenge-with-intravoxel-incoherent-motion-magnetic-resonance-imaging-in-healthy-volunteers
#5
Aude Pavilla, Alessandro Arrigo, Mehdi Mejdoubi, Régis Duvauferrier, Giulio Gambarota, Hervé Saint-Jalmes
OBJECTIVES: The aim of this study was to demonstrate the feasibility to assess cerebral hypoperfusion with a hyperventilation (HV) challenge protocol using intravoxel incoherent motion (IVIM) magnetic resonance imaging. MATERIALS AND METHODS: Magnetic resonance imaging experiments were performed on 10 healthy volunteers at 1.5 T, with a diffusion IVIM magnetic resonance imaging protocol using a set of b-values optimized by Cramer-Rao Lower Bound analysis. Hypoperfusion was induced by an HV maneuver...
July 13, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28708664/esmolol-administration-to-control-tachycardia-in-an-ovine-model-of-peritonitis
#6
Koji Hosokawa, Fuhong Su, Fabio Silvio Taccone, Emiel Hendrik Post, Adriano José Pereira, Antoine Herpain, Jacques Creteur, Jean-Louis Vincent
BACKGROUND: Excessive adrenergic signaling may be harmful in sepsis. Using β-blockers to reduce sympathetic overactivity may modulate sepsis-induced cardiovascular, metabolic, immunologic, and coagulation alterations. Using a randomized ovine fecal peritonitis model, we investigated whether administration of a short-acting β-blocker, esmolol, could control tachycardia without deleterious effects on hemodynamics, renal perfusion, cerebral perfusion, cerebral metabolism, or outcome. METHODS: After induction of fecal peritonitis, 14 anesthetized, mechanically ventilated, and hemodynamically monitored adult female sheep were randomly assigned to receive a continuous intravenous infusion of esmolol to control heart rate between 80 and 100 bpm (n = 7) or a saline infusion (control group, n = 7)...
July 13, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28704836/abdominal-near-infrared-spectroscopy-detects-low-mesenteric-perfusion-early-in-preterm-infants-with-hemodynamic-significant-ductus-arteriosus
#7
Ana Ledo, Marta Aguar, Antonio Núñez-Ramiro, Pilar Saénz, Máximo Vento
BACKGROUND: The therapeutic decision to close patent ductus arteriosus in preterm infants entails great uncertainty. Near-infrared spectroscopy is a noninvasive bedside technique used to monitor mixed regional oxygen saturation. We hypothesized that near-infrared spectroscopy could identify preterm infants at risk of mesenteric hypoperfusion associated with hemodynamically significant ductus arteriosus. METHODS: This is a prospective observational study including consecutively admitted preterm infants with a gestational age <32 weeks...
July 14, 2017: Neonatology
https://www.readbyqxmd.com/read/28701298/carotid-stenting-for-unilateral-stenosis-can-increase-contralateral-hemispheric-cerebral-blood-flow
#8
Akiyo Sadato, Shingo Maeda, Motoharu Hayakawa, Kazuhide Adachi, Hiroshi Toyama, Ichiro Nakahara, Yuichi Hirose
BACKGROUND: The revascularization of carotid stenosis can increase ipsilateral cerebral blood flow (CBF). Occasionally, elevated CBF is also evident on the contralateral side, but this phenomenon is poorly understood. OBJECTIVE: To analyze retrospectively the relationship between a contralateral CBF increase and several clinical and radiologic features. MATERIALS AND METHODS: We retrospectively analyzed 40 patients with unilateral cervical carotid stenosis treated by carotid artery stenting (CAS)...
July 12, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/28685455/cortical-oxyhemoglobin-elevation-persists-after-moderate-intensity-cycling-exercise-a-near-infrared-spectroscopy-study
#9
Atsuhiro Tsubaki, Nana Takehara, Daisuke Sato, Shinichiro Morishita, Yuta Tokunaga, Kazuhiro Sugawara, Sho Kojima, Hiroyuki Tamaki, Yudai Yamazaki, Hideaki Onishi
Near-infrared spectroscopy (NIRS) can measure cortical activity during gross motor tasks based on the cerebral hemodynamic response. Although some reports suggest that cycling exercise improves cortical oxygenation, its after-effects are unknown. We examined the after-effects of low- and moderate-intensity cycling exercise on cortical oxygenation. Ten healthy volunteers (mean age 21.3 ± 0.7 years; 4 women) underwent cycle ergometer exercise at 30% or 50% of VO2peak for 20 min, followed by an 8-min post-exercise rest (PER)...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28685449/relationships-between-gum-chewing-and-stroop-test-a-pilot-study
#10
Y Kawakami, T Takeda, M Konno, Y Suzuki, Y Kawano, T Ozawa, Y Kondo, K Sakatani
Cognitive function tends to decrease with aging, therefore maintenance of this function in an aging society is an important issue. The role of chewing in nutrition is important. Although several studies indicate that gum chewing is thought to improve cognitive function, it remains debatable whether gum-chewing does in fact improve cognitive function. The Stroop test is a psychological tool used to measure cognition. A shorter reaction time indicates a mean higher behavioral performance and higher levels of oxy-Hb concentration...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28680306/changes-in-cerebral-blood-flow-in-patients-with-familial-mediterranean-fever
#11
Gözde Çetin, Uygar Utku, Nurhan Atilla, Kadir Gişi, Mehmet Sayarlioğlu
INTRODUCTION: It is known that there is a relationship between systemic inflammation and atherosclerosis. Atherosclerosis is one of the best-known causes of cerebrovascular diseases. The aim of this study was to assess cerebral blood flow velocity using transcranial Doppler (TCD) ultrasonography in patients with familial Mediterranean fever (FMF). METHODS: A total of 30 patients aged from 20 to 50 years with FMF were enrolled in the FMF group consecutively. The control group (non-FMF group) consisted of 30 age- and sex-matched randomly selected patients without FMF who had other diagnoses such as fibromyalgia and did not have risk factors for atherosclerosis...
June 2017: Noro Psikiyatri Arsivi
https://www.readbyqxmd.com/read/28668343/changes-in-arterial-cerebral-blood-volume-during-lower-body-negative-pressure-measured-with-mri
#12
Joseph R Whittaker, Molly G Bright, Ian D Driver, Adele Babic, Sharmila Khot, Kevin Murphy
Cerebral Autoregulation (CA), defined as the ability of the cerebral vasculature to maintain stable levels of blood flow despite changes in systemic blood pressure, is a critical factor in neurophysiological health. Magnetic resonance imaging (MRI) is a powerful technique for investigating cerebrovascular function, offering high spatial resolution and wide fields of view (FOV), yet it is relatively underutilized as a tool for assessment of CA. The aim of this study was to demonstrate the potential of using MRI to measure changes in cerebrovascular resistance in response to lower body negative pressure (LBNP)...
June 28, 2017: NeuroImage
https://www.readbyqxmd.com/read/28665172/treatment-with-low-dose-fasudil-for-acute-ischemic-stroke-in-chronic-hypertension
#13
Siu-Lung Chan, Marilyn J Cipolla
We investigated the effect of Rho kinase inhibition on changes in cerebral blood flow (CBF), brain injury and vascular function after ischemic stroke in spontaneously hypertensive rats (SHR). Changes in core MCA and collateral perfusion were measured by a validated laser Doppler method. Animals underwent 2 h tMCAO and 2 h reperfusion. Fasudil (0.1 mg/kg, i.v.) or vehicle was given at 30 min ischemia (n = 9/group; mean (SD)). Brain injury was determined by 2,3,5-triphenyltetrazolium chloride staining...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28664392/validation-of-near-infrared-spectroscopy-for-monitoring-cerebral-autoregulation-in-comatose-patients
#14
Lucia Rivera-Lara, Romergryko Geocadin, Andres Zorrilla-Vaca, Ryan Healy, Batya R Radzik, Caitlin Palmisano, Marek Mirski, Wendy C Ziai, Charles Hogue
BACKGROUND: Transcranial Doppler (TCD) noninvasively measures cerebral blood flow (CBF) velocity and is a well-studied method to monitor cerebral autoregulation (CA). Near-infrared spectroscopy (NIRS) has emerged as a promising noninvasive method to determine CA continuously by using regional cerebral oxygen saturation (rSO2) as a surrogate for CBF. Little is known about its accuracy to determine CA in patients with intracranial lesions. The purpose of this study was to assess the accuracy of rSO2-based CA monitoring with TCD methods in comatose patients with acute neurological injury...
June 29, 2017: Neurocritical Care
https://www.readbyqxmd.com/read/28664319/effect-of-resolution-recovery-using-graph-plots-on-regional-cerebral-blood-flow-in-healthy-volunteers
#15
Nobuhiro Yada, Hideo Onishi, Masahiro Miyai, Kentarou Ozasa, Takashi Katsube, Keiichi Onoda, Masuo Haramoto, Yasushi Yamamoto, Shuhei Yamaguchi, Hajime Kitagaki
PURPOSE: We evaluated the effect of resolution recovery (RR) using graph plots on regional cerebral blood flow (rCBF) in brain perfusion single-photon emission computed tomography (SPECT) images derived from healthy volunteers and patients diagnosed with probable Alzheimer's disease. METHOD: We acquired brain perfusion SPECT images with scatter correction (SC), computed tomography-based attenuation correction (CTAC), and RR from a three-dimensional brain phantom and from healthy volunteers...
June 29, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28663374/extra-and-intra-cranial-blood-flow-regulation-during-the-cold-pressor-test-influence-of-age
#16
Daniela Flück, Philip N Ainslie, Anthony R Bain, Kevin W Wildfong, Laura Emily Morris, James P Fisher
We determined how the extra- and intra-cranial circulations respond to generalized sympathetic activation evoked by a cold pressor test (CPT) and whether this was affected by healthy aging. Ten young (23±2 yr; mean±SD) and nine older (66±3 yr) individuals performed a 3-min CPT by immersing the left foot into 0.8±0.3°C water. Common carotid artery (CCA) and internal carotid artery (ICA) diameter, velocity and flow were simultaneously measured (duplex ultrasound), along with middle cerebral artery and posterior cerebral artery mean blood velocity (MCAvmean and PCAvmean), and cardiorespiratory variables...
June 29, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28660179/monitoring-cerebral-and-renal-oxygenation-status-during-neonatal-digestive-surgeries-using-near-infrared-spectroscopy
#17
Jonathan Beck, Gauthier Loron, Claire Masson, Marie-Laurence Poli-Merol, Eliane Guyot, Camille Guillot, Nathalie Bednarek, Caroline François
BACKGROUND: Depending on the initial pathology, hypovolemia, intra-abdominal hypertension, and sepsis are often encountered in neonatal digestive surgery. Accurate newborn monitoring during and after surgery is essential to adapt resuscitation protocols. Near infrared spectroscopy (NIRS) is non-invasive and can detect hypoperfusion which indicates a low circulatory blood flow, regardless of the cause. OBJECTIVE: Evaluating changes in cerebral and renal regional oxygen saturation during neonatal digestive surgeries, conducted according to normal practices, with commonly used monitoring parameters...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28659787/better-correlation-of-cognitive-function-to-white-matter-integrity-than-to-blood-supply-in-subjects-with-leukoaraiosis
#18
Genlong Zhong, Ruiting Zhang, Yerfan Jiaerken, Xinfeng Yu, Ying Zhou, Chang Liu, Longting Lin, Lusha Tong, Min Lou
Leukoaraiosis is associated with increased risk of cognitive impairment, but its pathophysiological pathway is unclear. The aim of the present study was to determine whether brain structural damage or cerebral blood supply better correlated with the global cognitive outcome in subjects with leukoaraiosis. Seventy-five subjects with leukoaraiosis were included in present study, with age ranged from 43 to 85 years, with mean white matter hyperintensities (WMH) volume 30.69 ± 24.35 mL. Among them, 19(25.33%) subjects presented with cerebral microbleeds (CMB) and 40 (53...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28658875/efficacy-of-perfusion-computed-tomography-pct-in-differentiating-high-grade-gliomas-from-low-grade-gliomas-lymphomas-metastases-and-abscess
#19
Lakshmikanth Halegubbi Karegowda, Rajagopal Kadavigere, Poonam Mohan Shenoy, Samir Mustaffa Paruthikunnan
INTRODUCTION: Tumoural angioneogenesis and its quantification are important in predicting the tumour grade and in the management with respect to the treatment available and to assess the response to treatment and the prognosis. It also plays major role in the growth and spread of tumours. Hence, a need arises for non-invasive in vivo methods to assess tumour angioneogenesis and tumour grade at the time of presentation and for monitoring the response during treatment and follow up. In this regard Perfusion Computed Tomography (PCT) can be easily added into routine CT studies to obtain such information on lesion physiology along with its morphology...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28657491/novel-noninvasive-method-of-cerebrovascular-blood-volume-assessment-using-brain-bioimpedance
#20
Mohamad Hakam Tiba, Brendan M McCracken, Sardar Ansari, Ashwin Belle, Brandon C Cummings, Venkatakrishna Rajajee, Parag G Patil, Hasan B Alam, Kevin R Ward
Cerebro-vascular autoregulation (CAR) is the ability of vessels to modulate their tone in response to changes in pressure. CAR, as an auto-protective mechanism is critical in preventing secondary brain injury post trauma. Monitoring of changes in cerebral blood volume might be valuable in evaluating CAR and response to various therapies. In this study, we utilized an ocular-brain bioimpedance interface to assess real time changes in cerebral blood volume in response to a number of physiologic challenges. We hypothesize that changes in brain bioimpedance (dz) would track changes in cerebral blood volume...
June 28, 2017: Journal of Neurotrauma
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