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Mean cerebral blood flow

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https://www.readbyqxmd.com/read/28101162/correlation-between-high-perfusion-syndrome-and-stent-restenosis-after-stent-implantation
#1
Yingyi Li, Lingtao Tang, Dong Qi, Chunlei Wang, Suxia Zhang, Pengfei Hu, Yun Wang, Bogang Zhang, Kunxi Zhang
The present study was conducted to determine the correlation between high perfusion syndrome and stent restenosis after cerebral vascular stent implantation. A total of 146 patients diagnosed with cerebral vascular stenosis and stent implantation were selected. A total of 55 cases (37.67%) of cerebral hyperperfusion syndrome patients were diagnosed by xenon-enhanced computer tomography (Xe-CT) examination and clinical symptoms within 3 days after surgery and were chosen as the observation group. A total of 91 cases were selected as the control group...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28097330/electroencephalographic-periodic-discharges-and-frequency-dependent-brain-tissue-hypoxia-in-acute-brain-injury
#2
Jens Witsch, Hans-Peter Frey, J Michael Schmidt, Angela Velazquez, Cristina M Falo, Michael Reznik, David Roh, Sachin Agarwal, Soojin Park, E Sander Connolly, Jan Claassen
Importance: Periodic discharges (PDs) that do not meet seizure criteria, also termed the ictal interictal continuum, are pervasive on electroencephalographic (EEG) recordings after acute brain injury. However, their association with brain homeostasis and the need for clinical intervention remain unknown. Objective: To determine whether distinct PD patterns can be identified that, similar to electrographic seizures, cause brain tissue hypoxia, a measure of ongoing brain injury...
January 9, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28094088/usefulness-of-multiparametric-computerized-tomography-findings-in-the-differential-diagnosis-of-stroke-mimics-of-epileptic-origin-a-preliminary-study
#3
R López Ruiz, S Quintas, P Largo, M de Toledo, M T Carreras, A Gago-Veiga, R Manzanares, J Vivancos
OBJECTIVE: Thirty percent of the patients for whom code stroke is activated have stroke mimics, the most common being epilepsy. Our purpose was to evaluate the usefulness of multiparametric CT for differentiating between seizure-related symptoms and vascular events. MATERIAL AND METHODS: We conducted a retrospective observational study; data were gathered prospectively during one year. We studied multiparametric CT images of patients admitted following code stroke activation and finally diagnosed with epilepsy...
January 13, 2017: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/28068866/cognitive-abnormalities-and-cerebral-perfusion-defects-in-a-community-dwelling-cohort-of-elderly-men-with-mmse-within-the-normal-range
#4
Lena André-Petersson, Ola Thorsson, Arkadiusz Siennicki-Lantz
OBJECTIVES: Mini Mental State Examination's (MMSE's) sensitivity in its upper level is questioned, hence we investigated cognitive abnormalities and defects in regional cerebral blood flow (rCBF) in elderly with MMSE scores ≥24. METHODS: One hundred and four men at age 81 with MMSE scores ≥24 (mean 28.4 ± 1.7), no dementia or stroke, were examined with neuropsychological test battery, and their rCBF was estimated using (99mTc)-HMPAO SPECT. RESULTS: MMSE was very sparsely correlated with rCBF...
January 9, 2017: Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition
https://www.readbyqxmd.com/read/28057635/in-vivo-assessment-of-the-impact-of-regional-intracranial-atherosclerotic-lesions-on-brain-arterial-3d-hemodynamics
#5
C Wu, S Schnell, P Vakil, A R Honarmand, S A Ansari, J Carr, M Markl, S Prabhakaran
BACKGROUND AND PURPOSE: Intracranial atherosclerosis induces hemodynamic disturbance, which is not well-characterized, particularly in cerebral flow redistribution. We aimed to characterize the impact of regional stenotic lesions on intracranial hemodynamics by using 4D flow MR imaging. MATERIALS AND METHODS: 4D flow MR imaging was performed in 22 symptomatic patients (mean age, 68.4 ± 14.2 years) with intracranial stenosis (ICA, n = 7; MCA, n = 9; basilar artery, n = 6) and 10 age-appropriate healthy volunteers (mean age, 60...
January 5, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28052565/cerebral-hemodynamics-and-pseudo-continuous-arterial-spin-labeling-considerations-in-adults-with-sickle-cell-anemia
#6
Meher R Juttukonda, Lori C Jordan, Melissa C Gindville, Larry T Davis, Jennifer M Watchmaker, Sumit Pruthi, Manus J Donahue
Sickle cell anemia (SCA) is a genetic disorder resulting in reduced oxygen carrying capacity and elevated stroke risk. Pseudo-continuous arterial spin labeling (pCASL) measures of cerebral blood flow (CBF) may have relevance for stroke risk assessment; however, the effects of elevated flow velocity and reduced bolus arrival time (BAT) on CBF quantification in SCA patients have not been thoroughly characterized, and pCASL model parameters used in healthy adults are often applied to patients with SCA. Here, cervical arterial flow velocities and pCASL labeling efficiencies were computed in adults with SCA (n = 19) and age- and race-matched controls without sickle trait (n = 7) using pCASL in sequence with phase contrast MR angiography (MRA)...
January 4, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28049202/aortic-atherosclerosis-determines-increased-retrograde-blood-flow-as-a-potential-mechanism-of-retrograde-embolic-stroke
#7
Thomas Wehrum, Felix Guenther, Werner Vach, Beryl Primrose Gladstone, Sarah Wendel, Alexander Fuchs, Kehzong Wu, Christoph Johannes Maurer, Andreas Harloff
BACKGROUND: Retrograde brain embolization from complex plaques of the proximal descending aorta (DAo) has been identified as a new potential mechanism of stroke. Our purpose was to identify predictors of increased retrograde aortic blood flow indicating an elevated risk of brain embolization from the DAo. METHODS: A total of 485 patients with acute ischemic stroke were prospectively included and underwent transesophageal echocardiography. Blood flow velocities in the proximal DAo were studied using 2D pulse-wave Doppler ultrasound...
January 4, 2017: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/28048262/su-g-iep1-07-inaccuracy-of-lesion-blood-flow-quantification-related-to-the-proton-density-reference-image-in-arterial-spin-labeling-mri-of-brain-tumors
#8
M Jen, J Johnson, P Hou, H Liu
PURPOSE: Cerebral blood flow quantification in arterial spin labeling (ASL) MRI requires an estimate of the equilibrium magnetization of blood, which is often obtained by a set of proton density (PD) reference image. Normally, a constant blood-brain partition coefficient is assumed across the brain. However, this assumption may not be valid for brain lesions. This study aimed to evaluate the impact of lesion-related PD variations on ASL quantification in patients with brain tumors. METHODS: MR images for posttreatment evaluation of 42 patients with brain tumors were retrospectively analyzed...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046971/th-cd-206-01-expectation-maximization-algorithm-based-tissue-mixture-quantification-for-perfusion-mri
#9
H Han, Z Liang, L Li, L Xing
PURPOSE: To investigate the feasibility of estimating the tissue mixture perfusions and quantifying cerebral blood flow change in arterial spin labeled (ASL) perfusion MR images. METHODS: The proposed perfusion MR image analysis framework consists of 5 steps: (1) Inhomogeneity correction was performed on the T1- and T2-weighted images, which are available for each studied perfusion MR dataset. (2) We used the publicly available FSL toolbox to strip off the non-brain structures from the T1- and T2-weighted MR images...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046770/su-g-iep1-12-size-selective-arterial-cerebral-blood-volume-mapping-using-multiple-inversion-time-arterial-spin-labeling
#10
Y Jung, M Johnston, H Liu, C Whitlow
PURPOSE: To demonstrate the feasibility of a novel method for size specific arterial cerebral blood volume (aCBV) mapping using pseudo-continuous arterial spin labeling (PCASL), with multiple TI. METHODS: Multiple PCASL images were obtained from a subject with TI of [300, 400, 500, 600, 700, 800, 900, 1000, 1500, 2000, 2500, 3000, 3500, 4000] ms. Each TI pair was averaged six times. Two scans were performed: one without a flow crusher gradient and the other with a crusher gradient (10cm/s in three directions) to remove signals from large arteries...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28039210/relationship-between-tissue-doppler-measurements-of-left-ventricular-diastolic-function-and-silent-brain-infarction-in-patients-with-non-valvular-atrial-fibrillation
#11
Sera Ishikawa, Kenichi Sugioka, Shinichi Sakamoto, Suwako Fujita, Asahiro Ito, Naoki Norioka, Shinichi Iwata, Masashi Nakagawa, Masahiko Takagi, Yukio Miki, Makiko Ueda, Minoru Yoshiyama
AIMS: Left ventricular (LV) diastolic function assessed by tissue Doppler imaging (TDI) is reported to be associated with left atrial (LA) blood stasis in patients with non-valvular atrial fibrillation (AF). This study aimed to evaluate the relationship of diastolic TDI parameters with silent brain infarction (SBI) on brain magnetic resonance imaging (MRI), and in turn the risks of subsequent stroke or dementia, in non-valvular AF patients. METHODS AND RESULTS: The study population consisted of 171 neurologically asymptomatic patients with non-valvular AF who underwent transoesophageal echocardiography (TOE) (128 men; mean age, 63 ± 11 years)...
December 29, 2016: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28031423/neurologic-injury-and-cerebral-blood-flow-in-single-ventricles-throughout-staged-surgical-reconstruction
#12
Mark A Fogel, Christine J Li, Okan U Elci, Tom Pawlowski, Peter J Schwab, Felice B Wilson, Susan C Nicolson, Lisa M Montenegro, Laura Diaz, Thomas L Spray, J William Gaynor, Stephanie Fuller, Christopher E Mascio, Marc S Keller, Matthew A Harris, Kevin K Whitehead, James Bethel, Arastoo Vossough, Daniel J Licht
BACKGROUND: -Single ventricle patients experience a high rate of brain injury and adverse neurodevelopmental outcome, however, the incidence of brain abnormalities throughout surgical reconstruction and its relationship with cerebral blood flow, oxygen delivery and carbon dioxide reactivity remains unknown. METHODS: -Single ventricle patients were studied with MRI scans immediately prior to bidirectional Glenn (pre-BDG), prior to Fontan and then 3-9 months after Fontan reconstruction...
December 28, 2016: Circulation
https://www.readbyqxmd.com/read/28026888/measurement-of-blood-flow-in-an-intracranial-artery-bypass-from-the-internal-maxillary-artery-by-intraoperative-duplex-sonography
#13
Zaitao Yu, Xiang'en Shi, Shams Raza Brohi, Hai Qian, Fangjun Liu, Yang Yang
This study explored the hemodynamic characteristics of a subcranial-intracranial bypass from the internal maxillary artery by measuring blood flow on intraoperative duplex sonography. The hemodynamic parameters of the internal maxillary artery (n = 20), radial artery (n = 20), internal maxillary artery-middle cerebral artery bypass (n = 42), and internal maxillary artery-posterior cerebral artery bypass (n = 9) were measured by intraoperative duplex sonography. There was no significant difference in the internal diameters of the internal maxillary and radial arteries (mean ± SD, 2...
December 27, 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28012450/exploring-sexual-dimorphism-in-placental-circulation-at-22-24-weeks-of-gestation-a-cross-sectional-observational-study
#14
Christian Widnes, Kari Flo, Ganesh Acharya
INTRODUCTION: Placental blood flow is closely associated with fetal growth and wellbeing. Recent studies suggest that there are differences in blood flow between male and female fetuses. We hypothesized that sexual dimorphism exists in fetal and placental blood flow at 22-24 weeks of gestation. METHODS: This was a prospective cross-sectional study of 520 healthy pregnant women. Blood flow velocities of the middle cerebral artery (MCA), umbilical artery (UA), umbilical vein (UV) and the uterine arteries (UtA) were measured using Doppler ultrasonography...
January 2017: Placenta
https://www.readbyqxmd.com/read/28007503/low-spontaneous-variability-in-cerebral-blood-flow-velocity-in-non-survivors-after-cardiac-arrest
#15
J M D van den Brule, E J Vinke, L M van Loon, J G van der Hoeven, C W E Hoedemaekers
OBJECTIVE: To investigate spontaneous variability in the time and frequency domain in mean flow velocity (MFV) and mean arterial pressure (MAP) in comatose patients after cardiac arrest, and determine possible differences between survivors and non-survivors. METHODS: A prospective observational study was performed at the ICU of a tertiary care university hospital in the Netherlands. We studied 11 comatose patients and 10 controls. MFV in the middle cerebral artery was measured with simultaneously recording of MAP...
December 19, 2016: Resuscitation
https://www.readbyqxmd.com/read/28006726/perfusion-deconvolution-in-dsc-mri-with-dispersion-compliant-bases
#16
Marco Pizzolato, Timothé Boutelier, Rachid Deriche
Perfusion imaging of the brain via Dynamic Susceptibility Contrast MRI (DSC-MRI) allows tissue perfusion characterization by recovering the tissue impulse response function and scalar parameters such as the cerebral blood flow (CBF), blood volume (CBV), and mean transit time (MTT). However, the presence of bolus dispersion causes the data to reflect macrovascular properties, in addition to tissue perfusion. In this case, when performing deconvolution of the measured arterial and tissue concentration time-curves it is only possible to recover the effective, i...
December 6, 2016: Medical Image Analysis
https://www.readbyqxmd.com/read/27999986/post-treatment-changes-of-tumour-perfusion-parameters-can-help-to-predict-survival-in-patients-with-high-grade-astrocytoma
#17
Roberto Sanz-Requena, Antonio J Revert-Ventura, Gracián García-Martí, Fares Salamé-Gamarra, Alexandre Pérez-Girbés, Enrique Mollá-Olmos, Luis Martí-Bonmatí
OBJECTIVES: Vascular characteristics of tumour and peritumoral volumes of high-grade gliomas change with treatment. This work evaluates the variations of T2*-weighted perfusion parameters as overall survival (OS) predictors. METHODS: Forty-five patients with histologically confirmed high-grade astrocytoma (8 grade III and 37 grade IV) were included. All patients underwent pre- and post-treatment T2*-weighted contrast-enhanced magnetic resonance (MR) imaging. Tumour, peritumoral and control volumes were segmented...
December 20, 2016: European Radiology
https://www.readbyqxmd.com/read/27998779/systemic-blood-pressure-alters-cortical-blood-flow-and-neurovascular-coupling-during-nociceptive-processing-in-the-primary-somatosensory-cortex-of-the-rat
#18
Sae Uchida, Suzie Bois, Jean-Paul Guillemot, Hugues Leblond, Mathieu Piché
Inference on nociceptive and pain-related processes from functional magnetic resonance imaging is made with the assumption that the coupling of neuronal activity and cerebral hemodynamic changes is stable. However, since nociceptive stimulation is associated with increases in systemic arterial pressure, it is essential to determine whether this coupling remains the same during different levels of nociception and pain. The main objective of the present study was to compare the amplitude of local field potentials (LFP) and cerebral blood flow (CBF) changes in the primary somatosensory cortex during nociceptive electrical stimulation of the contralateral or ipsilateral forepaw in isoflurane-anesthetized rats, while manipulating mean arterial pressure (MAP)...
December 18, 2016: Neuroscience
https://www.readbyqxmd.com/read/27989553/cerebrovascular-function-in-presymptomatic-and-symptomatic-individuals-with-hereditary-cerebral-amyloid-angiopathy-a-case-control-study
#19
Anna M van Opstal, Sanneke van Rooden, Thijs van Harten, Eidrees Ghariq, Gerda Labadie, Panagiotis Fotiadis, M Edip Gurol, Gisela M Terwindt, Marieke J H Wermer, Mark A van Buchem, Steven M Greenberg, Jeroen van der Grond
BACKGROUND: Previous work suggests that impairments of cerebrovascular flow or reactivity might be early markers of cerebral amyloid angiopathy (CAA). Hereditary cerebral haemorrhage with amyloidosis-Dutch type (HCHWA-D) is a genetic form of CAA that can be diagnosed before the onset of clinical symptoms by DNA testing. We aimed to investigate whether haemodynamic measures are decreased in presymptomatic and symptomatic HCHWA-D mutation carriers compared with healthy controls. METHODS: In this case-control study, we included presymptomatic and symptomatic HCHWA-D mutation carriers diagnosed through genetic testing and recruited through the HCHWA-D patient association (Katwijk, Netherlands) and the outpatient clinic of the Department of Neurology of the Leiden University Medical Center (Leiden, Netherlands), and healthy controls...
February 2017: Lancet Neurology
https://www.readbyqxmd.com/read/27982773/effect-of-combined-vegf165-sdf-1-gene-therapy-on-vascular-remodeling-and-blood-perfusion-in-cerebral-ischemia
#20
Guo-Jie Hu, Yu-Gong Feng, Wen-Peng Lu, Huan-Ting Li, Hong-Wei Xie, Shi-Fang Li
OBJECTIVE Therapeutic neovascularization is a promising strategy for treating patients after an ischemic stroke; however, single-factor therapy has limitations. Stromal cell-derived factor 1 (SDF-1) and vascular endothelial growth factor (VEGF) proteins synergistically promote angiogenesis. In this study, the authors assessed the effect of combined gene therapy with VEGF165 and SDF-1 in a rat model of cerebral infarction. METHODS An adenoviral vector expressing VEGF165 and SDF-1 connected via an internal ribosome entry site was constructed (Ad-VEGF165-SDF-1)...
December 16, 2016: Journal of Neurosurgery
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