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https://www.readbyqxmd.com/read/29908452/transcriptomics-provides-mechanistic-indicators-of-fluoride-toxicology-on-endochondral-ossification-in-the-hind-limb-of-bufo-gargarizans
#1
Wu Chao, Yuhui Zhang, Lihong Chai, Hongyuan Wang
Endochondral ossification, the process by which most of the bone is formed, is regulated by many specific groups of molecules and extracellular matrix components. Hind limb of Bufo gargarizans is a model to study endochondral ossification during metamorphosis. Chinese toad (Bufo gargarizans) were exposed to different fluoride concentrations (0, 1, 5, 10 and 20 mg L-1 ) from G3 to G42. The development of hind limb of B. gargarizans was observed using the double staining methodology. The transcriptome of hind limb of B...
June 10, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29905969/vitamin-d-supplementation-in-elderly-black-women-does-not-prevent-bone-loss-a-randomized-controlled-trial
#2
John F Aloia, Melissa Fazzari, Shahidul Islam, Mageda Mikhail, Subhashini Katumuluwa, Ruban Dhaliwal, Alexandra Stolberg, Gianina Usera, Louis Ragolia
Black Americans have lower levels of serum 25(OH)D but superior bone health compared to white Americans. There is controversy over whether they should be screened for vitamin D deficiency and have higher vitamin D requirements than recommended by the Institute of Medicine (IOM). The purpose of this trial was to determine whether Vitamin D supplementation in elderly black women prevents bone loss. 260 healthy black American women, 60 years of age and older were recruited to take part in a two arm, double-dummy 3 year RCT of vitamin D3 vs...
June 15, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29905044/-correlation-analysis-between-interleukin-6-polymorphism-and-adolescent-idiopathic-scoliosis-susceptibility-and-bracing-effectiveness
#3
Junsheng Gao, Lu Zhang, Zhiang Liu, Shuaihui Yao, Songming Gao
Objective: To analyze the correlation between the polymorphism on interleukin 6 (IL-6) gene promoter region-174 locus and adolescent idiopathic scoliosis (AIS), including the susceptibility, the bracing effectiveness, and the possible mechanism. Methods: The 182 AIS patients and 210 healthy controls who met the inclusion criteria between January 2013 and January 2016 were collected as research objects. The genotype of IL-6 gene promoter region-174 locus, the serum IL-6, the bone mineral density (BMD) of femoral neck and vertebrae (L 1-4 ), and the bone metabolism parameters, including bone alkaline phosphatase (BALP), bone gla protein (BGP), tartrate resistant acid phosphatase 5b (TRACP-5b), urine Ca, and urine Ca/Cr, were detected...
June 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/29904422/prolyl-oligopeptidase-inhibitor-suppresses-the-upregulation-of-acsdkp-in-patients-with-acute-myeloid-leukemia
#4
Haiwu Cao, Xiaohong Zhao, Shiyun Lu, Zhi Wang
The aim of the current study was to measure the expression of acetyl-N-Ser-Asp-Lys-Pro (ACSDKP) in patients with acute myeloid leukemia (AML) and the effect of prolyl oligopeptidase inhibitor (POPi) on the bone marrow stromal cells of these patients. Serum and bone marrow stromal cell samples were collected from 33 patients with AML admitted to Wuxi Second People's Hospital, Nanjing Medical University between September 2011 and August 2016. ACSDKP levels were measured using a highly specific competitive enzyme immunoassay (EIA)...
June 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29902786/the-impact-of-two-stage-subtotal-petrosectomy-and-round-window-vibroplasty-on-bone-conduction-thresholds
#5
Nils Kristian Prenzler, Lennart Gruber, Thomas Lenarz, Hannes Maier, Burkard Schwab
OBJECTIVE: To evaluate possible increases in bone conduction (BC) hearing thresholds in patients undergoing subtotal petrosectomy (SP) with fat obliteration and blind sac closure of the outer ear canal and subsequent round window vibroplasty. PATIENTS AND INTERVENTIONS: Between 1997 and 2013, 43 patients (45 ears) with combined hearing loss and recurrent chronic otitis or status post formation of a radical cavity underwent SP around 6 months prior to implantation of a Vibrant SoundbridgeTM...
June 14, 2018: ORL; Journal for Oto-rhino-laryngology and its related Specialties
https://www.readbyqxmd.com/read/29901636/male-patients-with-rheumatoid-arthritis-have-an-increased-risk-of-osteoporosis-frequency-and-risk-factors
#6
Seong-Min Kweon, Dong Hyun Sohn, Ji-Heh Park, Jung Hee Koh, Eun-Kyoung Park, Han-Na Lee, Keunyoung Kim, Yunkyung Kim, Geun-Tae Kim, Seung-Geun Lee
Most previous research investigating osteoporosis in rheumatoid arthritis (RA) has focused on female patients and there is a lack of data regarding clinical characteristics of osteoporosis in male patients with RA.The aim of this study was to compare the frequency of osteoporosis between male patients with RA and healthy patients, and to identify the risk factors for osteoporosis and low bone mineral density (BMD) in male patients with RA.We conducted a retrospective, cross-sectional study including 76 South Korean male patients with RA aged over 50 years and 76 age-matched male healthy individuals...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29901504/vertebral-augmentation-is-superior-to-nonoperative-care-at-reducing-lower-back-pain-for-symptomatic-osteoporotic-compression-fractures-a-meta-analysis
#7
Sina Pourtaheri, William Luo, Christina Cui, Steven Garfin
STUDY DESIGN: This is a systematic review and meta-analysis. OBJECTIVE: This study's goal was to (i) assess the clinical outcomes with and without vertebral augmentation (VA) for osteoporotic vertebral compression fractures (VCFs) with versus without correlating signs and symptoms; and (ii) acute (symptoms <3 mo duration) and subacute VCFs (3-6 mo duration) versus chronic VCFs (>6 mo). SUMMARY OF BACKGROUND DATA: Previously, a randomized controlled trial in the New England Journal of Medicine concluded that vertebroplasty for osteoporotic VCFs provided no clinical benefit over sham surgery...
June 12, 2018: Clinical Spine Surgery
https://www.readbyqxmd.com/read/29900480/bioactive-hybrid-zirconia-implant-surface-for-enhancing-osseointegration-an-in-vivo-study
#8
Dawlat Mostafa, Moustafa Aboushelib
BACKGROUND: Zirconia is characterized by a hard, dense, and chemically inert surface which requires additional surface treatments in order to enhance osseointegration. The proposed hypothesis of the study was that combination of a nano-porous surface infiltrated with a bioactive material may enhance osseointegration of zirconia implants. METHODS: Custom-made zirconia implants (3.7 mm × 8 mm) were designed, milled, and sintered according to manufacturer recommendations...
June 14, 2018: International Journal of Implant Dentistry
https://www.readbyqxmd.com/read/29900162/association-of-insulin-resistance-with-lower-bone-volume-and-strength-index-of-the-proximal-femur-in-nondiabetic-postmenopausal-women
#9
Jaewon Yang, Namki Hong, Jee-Seon Shim, Yumie Rhee, Hyeon Chang Kim
Background: Type 2 diabetes mellitus is associated with an increased risk of osteoporotic fracture despite relatively preserved bone mineral density (BMD). Although this paradox might be attributed to the influence of insulin resistance (IR) on bone structure and material properties, the association of IR with femur bone geometry and strength indices remains unclear. Methods: Using data from the Cardiovascular and Metabolic Disease Etiology Research Center cohort study, we conducted a cross-sectional analysis among nondiabetic postmenopausal women...
May 2018: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/29900160/improvement-of-osteoporosis-medication-after-multimodal-intervention-in-patients-with-hip-fracture-prospective-multicenter-study
#10
Yong-Geun Park, Kwang Woo Nam, Sang-Rim Kim, Min-Suk Park, Sang-Jae Kim, Yong-Chan Ha
Background: The authors had earlier conducted a retrospective cohort study from 2008 to 2011 in Jeju Island, among 945 hip fracture patients above 50 years of age. Of these 945 patients, 344 patients (36.4%) underwent a bone mineral density test and 218 patients (23.1%) received treatment for osteoporosis. The purpose of this study was to determine whether a patient education program could improve osteoporosis management after hip fracture. The data of the previous study was used for comparison...
May 2018: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/29900158/high-plasma-sphingosine-1-phosphate-levels-predict-osteoporotic-fractures-in-postmenopausal-women-the-center-of-excellence-for-osteoporosis-research-study
#11
Mohammed-Salleh M Ardawi, Abdulrahim A Rouzi, Nawal S Al-Senani, Mohammed H Qari, Ayman Z Elsamanoudy, Shaker A Mousa
Background: Higher sphingosine 1-phosphate (S1P) plasma levels are associated with decreased bone mineral density (BMD), and increased risk of prevalent vertebral fracture. So, we hypothesized that postmenopausal women with increased baseline plasma S1P levels have a greater risk for future incident fracture (osteoporosis-related fractures [ORFs]). Methods: This study was conducted in a prospective longitudinal cohort of 707 women recruited in 2004 and followed up annually for a mean period of 5...
May 2018: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/29898932/management-of-bone-health-in-patients-with-celiac-disease-practical-guide-for-clinicians
#12
REVIEW
Donald Duerksen, Maria Ines Pinto-Sanchez, Alexandra Anca, Joyce Schnetzler, Shelley Case, Jenni Zelin, Adrianna Smallwood, Justine Turner, Elena Verdú, J Decker Butzner, Mohsin Rashid
OBJECTIVE: To describe clinical issues related to bone health in patients with celiac disease (CD) and to provide guidance on monitoring bone health in these patients. SOURCES OF INFORMATION: A PubMed search was conducted to review literature relevant to CD and bone health, including guidelines published by professional gastroenterological organizations. MAIN MESSAGE: Bone health can be negatively affected in both adults and children with CD owing to the inflammatory process and malabsorption of calcium and vitamin D...
June 2018: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/29898779/melatonin-rescued-interleukin-1%C3%AE-impaired-chondrogenesis-of-human-mesenchymal-stem-cells
#13
Bo Gao, Wenjie Gao, Zizhao Wu, Taifeng Zhou, Xianjian Qiu, Xudong Wang, Chengjie Lian, Yan Peng, Anjing Liang, Jincheng Qiu, Yuanxin Zhu, Caixia Xu, Yibing Li, Peiqiang Su, Dongsheng Huang
BACKGROUND: Osteoarthritis (OA) is a widespread arthritic disease and a primary cause of disability. Increasing evidence suggests that inflammation has a pivotal part in its pathogenesis. Interleukin-1β (IL-1β) is a primary mediator of local inflammatory processes in OA. Current therapies for OA mainly focus on the symptoms of the advanced stage of the disease. The possible utilization of bone marrow mesenchymal stem cells (BMSCs) to regenerate cartilage is an appealing method, but in the case of OA requires chondrogenesis to take place within an inflamed environment...
June 14, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29898022/comparative-study-of-oral-and-salivary-parameters-in-patients-with-and-without-loss-of-bone-mass
#14
Igor Figueiredo Pereira, Cláudia Borges Brasileiro, Núbia Priscilla Kleperon, Mauro Henrique Nogueira Guimarães de Abreu, Tarcília Aparecida da Silva, Ricardo Alves Mesquita, Tania Mara Pimenta Amaral
Osteoporosis is an insidious and increasingly prevalent disease that can cause fractures and affect patients' quality of life. The current study comparatively evaluates patients with and without loss of bone mass in terms of salivary calcium, viscosity, and pH. A controlled cross-sectional study was conducted in two groups of 32 postmenopausal women subjected to a bone densitometry scan and later referred for dental management at the Federal University of Minas Gerais, Brazil. The patients were assigned to two groups: Group 1 - patients with low bone mineral density (BMD) and Group 2 - patients without bone mineral changes...
June 7, 2018: Brazilian Oral Research
https://www.readbyqxmd.com/read/29898018/complications-with-pmma-compared-with-other-materials-used-in-cranioplasty-a-systematic-review-and-meta-analysis
#15
Rafaella de Souza Leão, Juliana Raposo Souto Maior, Cleidiel Aparecido de Araújo Lemos, Belmiro Cavalcanti do Egito Vasconcelos, Marcos Antônio Japiassú Resende Montes, Eduardo Piza Pellizzer, Sandra Lúcia Dantas Moraes
Polymethyl methacrylate (PMMA) has been considered a suitable material for cranioplasty. However, no consensus has been reached concerning the best material for cranioplasty with regard to minimizing complications. Thus, this systematic review and meta-analysis aimed to compare the complication rates of PMMA with those of autologous bone and titanium mesh. This review was registered with PROSPERO (CRD42016042725). Systematic searches were conducted on PubMed/MEDLINE, Scopus, and Web of Science. The focus question was, "Do PMMA prostheses used in cranioplasty have complications rates similar to those of autologous bone and titanium mesh?" A meta-analysis of complication rates was performed on the basis of dichotomous outcomes assessed by risk ratio (RR) with corresponding 95% confidence intervals (CI)...
June 7, 2018: Brazilian Oral Research
https://www.readbyqxmd.com/read/29897928/nonalcoholic-fatty-liver-disease-with-elevated-alanine-aminotransferase-levels-is-negatively-associated-with-bone-mineral-density-cross-sectional-study-in-u-s-adults
#16
Toshihiro Umehara
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) has been reported to have a negative effect on bone mineral density (BMD) in Asian populations. Whether such an association exists in Western populations is less clear. METHODS: This cross-sectional analysis of data from NHANES III, a United States national health survey conducted from 1988 to 1994, included 6089 participants aged 40-75 years, selected after excluding people with hepatitis virus serology, elevated alcohol consumption, decreased renal function, or steroid use, and pregnant females...
2018: PloS One
https://www.readbyqxmd.com/read/29893317/the-effect-of-gel-homogeneity-on-dose-response-in-a-low-density-polymer-gel-dosimeter-for-radiation-therapy
#17
Mehrdad Gholami, Daryoush Shahbazi-Gahrouei
Background: The human body consists of a variety of tissues and cavities with different physical and radiological properties. The most important among these are tissues and cavities including lungs, oral cavities, teeth, nasal passages, sinuses, and bones. Thus, the dose distribution in these tissues cannot be verified with soft tissue equivalent polymer gel dosimeters. This study is conducted to evaluate the effect of homogeneity on dose response of an anoxic low-density polymer gel dosimeter for radiation therapy...
April 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29892528/to-determine-the-efficacy-of-ultrasonography-in-the-evaluation-of-bone-fill-at-the-regenerate-site-for-mandibular-distraction-osteogenesis-over-clinical-and-radiographic-assessment-an-in-vivo-prospective-study
#18
Neelam Andrade, Neha Aggrawal, Guruprasad Jadhav, Vyankatesh Sahu, Paul C Mathai
Until date conventional radiographs and computed tomography are the preferred diagnostic modalities to monitor the distraction osteogenesis regenerate. But these techniques do not detect the ongoing osteogenic process; moreover they obligate the patient to serial radiation exposure. In addition, anatomic overlap and metal artifacts obscure the virtual findings. In contrast, ultrasound is a noninvasive, efficient and an inexpensive way to evaluate bone healing. This study was conducted to test the efficacy of ultrasound in evaluating bone healing at the mandibular distraction site...
May 2018: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/29890312/the-characterization-and-potential-roles-of-bone-morphogenetic-protein-7-during-spermatogenesis-in-chinese-mitten-crab-eriocheir-sinensis
#19
Ya-Ru Xu, Gao-Yuan Wang, Yi-Chao Zhou, Wan-Xi Yang
Bone morphogenetic proteins (BMPs), which belong to the transforming growth factor-β superfamily, have been implicated in various biological and physiological processes, especially in the gonad development. However, scarce studies were focused on the roles of BMPs in the reproductive system of crustaceans. In this study, the whole gene encoding BMP7 protein was cloned and characterized firstly in Chinese mitten crab Eriocheir sinensis. The bioinformatics analysis of the deduced amino acid sequence showed that Es-BMP7 was composed of prodomain/latency-associated peptide and the TGF-β characteristic domain...
June 8, 2018: Gene
https://www.readbyqxmd.com/read/29890262/disease-modifying-effects-of-cox-2-selective-inhibitors-and-non-selective-nsaids-in-osteoarthritis-a-systematic-review
#20
REVIEW
Ken Nakata, Tatsuhiro Hanai, Yasuhiro Take, Takeshi Osada, Takanori Tsuchiya, Daisuke Shima, Yoko Fujimoto
Osteoarthritis (OA) is a potentially disabling disease whose progression is dependent on several risk factors. OA management usually involves the use of non-steroidal anti-inflammatory drugs (NSAIDs) that are the primary pharmacological treatments of choice. However, NSAIDs have often been associated with unwanted side effects. Cyclooxygenase (COX)-2 specific inhibitors, such as celecoxib, have been successfully used as an alternative in the past for OA treatment and have demonstrated fewer side effects. While abundant data are available for the clinical efficacy of drugs used for OA treatment, little is known about the disease-modifying effects of these agents...
June 8, 2018: Osteoarthritis and Cartilage
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