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https://www.readbyqxmd.com/read/29443791/direction-changeable-lumbar-cage-versus-traditional-lumbar-cage-for-treating-lumbar-spondylolisthesis-a-retrospective-study
#1
Haiping Zhang, Yonghong Jiang, Biao Wang, Qinpeng Zhao, Simin He, Dingjun Hao
Despite the diverse designs for the lumbar interbody fusion cage, there is no consensus on the optimal design to date. The current study aimed to compare the efficacy and complications associated with the direction-changeable and traditional lumbar cages for treating lumbar spondylolisthesis.We conducted a retrospective study including 109 patients with lumbar spondylolisthesis, who were admitted to our hospital from January 2013 to December 2014. The patients were divided into the direction-changeable (group A) and traditional (group B) lumbar cage group...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29441735/the-role-of-mmu-mir-155-5p-nf-%C3%AE%C2%BAb-signaling-in-the-education-of-bone-marrow-derived-mesenchymal-stem-cells-by-gastric-cancer-cells
#2
Mei Wang, Fang Yang, Rong Qiu, Mengchu Zhu, Huiling Zhang, Wenrong Xu, Bo Shen, Wei Zhu
Bone marrow-derived mesenchymal stem cells (BM-MSCs) are important precursors of tumor stromal cells. Previously, we have demonstrated that miR-155-5p inhibition directly induced transition of BM-MSCs into gastric cancer-associated MSCs. Whether miR-155-5p is involved in the education of BM-MSCs by gastric cancer cells has not been established. Murine BM-MSCs (mMSCs) were isolated and grown in conditioned medium derived from gastric cancer cell line MFC (MFC-CM). The tumor-promoting phenotype and function of mMSCs were detected by immunofluorescence staining, quantitative reverse transcription-polymerase chain reaction (qRT-PCR), cell colony formation assay, transwell migration, and invasion assays...
February 14, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29439654/prospective-study-on-human-fecal-carriage-of-enterobacteriaceae-possessing-mcr-1-and-mcr-2-genes-in-a-regional-hospital-in-hong-kong
#3
Wai-Sing Chan, Chun-Hang Au, Dona N Ho, Tsun-Leung Chan, Edmond Shiu-Kwan Ma, Bone Siu-Fai Tang
BACKGROUND: Human fecal carriage of Enterobacteriaceae possessing mobilized colistin resistance genes (mcr-1 and mcr-2) remains obscure in Hong Kong. As part of routine surveillance on emerging antibiotic resistance, we conducted a prospective study on this topic in a regional hospital in Hong Kong. METHODS: From October 31 to November 25, 2016, all fecal specimens submitted for routine analysis were included in this surveillance study. These comprised 672 consecutive routine fecal specimens collected from 616 individuals...
February 13, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29439419/immunoconjugates-for-osteosarcoma-therapy-preclinical-experiences-and-future-perspectives
#4
REVIEW
Daniele Mercatelli, Massimo Bortolotti, Alberto Bazzocchi, Andrea Bolognesi, Letizia Polito
Osteosarcoma (OS) is an aggressive osteoid-producing tumor of mesenchymal origin, which represents the most common primary bone malignancy. It is characterized by a complex and frequently uncertain etiology. The current standard care for high-grade OS treatment is neoadjuvant chemotherapy, followed by surgery and post-operative chemotherapy. In order to ameliorate survival rates of patients, new therapeutic approaches have been evaluated, mainly immunotherapy with antibody-drug conjugates or immunoconjugates...
February 10, 2018: Biomedicines
https://www.readbyqxmd.com/read/29438552/estrogen-replacement-in-turner-syndrome-literature-review-and-practical-considerations
#5
Karen O Klein, Robert Rosenfield, Richard J Santen, Aneta Gawlik, Philippe Backeljauw, Claus H Gravholt, Theo Sas, Nelly Mauras
Context: Most girls with Turner Syndrome have hypergonadotropic hypogonadism and need hormonal replacement - for induction of puberty and later maintaining secondary sex characteristics, attaining peak bone mass, and uterine growth. The optimal estrogen replacement regimen is still being studied. Evidence Acquisition: We conducted a systematic search of PubMed for research related to TS and puberty, including key words: estrogen, growth, puberty. Evidence Synthesis: The goals of replacement are to mimic normal timing and progression of physical and social development while minimizing risks...
February 8, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29437791/a-phase-i-study-of-cpi-613-in-combination-with-high-dose-cytarabine-and-mitoxantrone-for-relapsed-or-refractory-acute-myeloid-leukemia
#6
Timothy S Pardee, Rebecca G Anderson, Kristin M Pladna, Scott Isom, Lais P Ghiraldeli, Lance D Miller, Jeff A Chou, Guangxu Jin, Wei Zhang, Leslie R Ellis, Dmitriy Berenzon, Dianna S Howard, David Hurd, Megan Manuel, Sarah Dralle, Susan Lyerly, Bayard L Powell
PURPOSE: CPI-613, a lipoate analog that inhibits pyruvate dehydrogenase (PDH) and α-ketogluterate dehydrogenase (KGDH) has activity in patients with myeloid malignancies. This study explored the role of mitochondrial metabolism in chemotherapy response, determined the maximally tolerated dose, efficacy and safety of CPI-613 combined with high dose cytarabine and mitoxantrone in patients with relapsed or refractory acute myeloid leukemia. METHODS: The role of mitochondrial response to chemotherapy was assessed in cell lines and animal models...
February 6, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29437025/association-between-vitamin-k-epoxide-reductase-vkorc1-1639g-a-polymorphism-and-osteoporosis-in-postmenopausal-women
#7
Faruk Kutluturk, Ahmet Inanir, Aydın Rustemoglu, Suheyla Kaya, Ayse Kevser Demir, Gul Dursun, Serbulent Yigit
Introductıon: Osteoporosis is a common disease, and several factors contribute to its development. Recently, there has been increasing evidence that vitamin K (VK) plays a critical role in maintaining bone strength. Vitamin K serves as a co-factor for the γ-carboxylation of particular proteins to convert specific glutamic acid residues to γ-carboxyglutamic acid residues. This process involves two enzymes, γ-glutamyl carboxylase and vitamin K epoxide reductase (VKORC1). The number of studies investigating the effects of VKORC1 gene mutations on bone mineral density in postmenopausal osteoporosis patients is limited...
February 11, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29435621/effect-of-selective-serotonin-reuptake-inhibitors-on-bone-mineral-density-a-systematic-review-and-meta-analysis
#8
REVIEW
C Zhou, L Fang, Y Chen, J Zhong, H Wang, P Xie
Our work is the first systematic meta-analysis to investigate the effect of selective serotonin reuptake inhibitor (SSRI) medication on bone mineral density. Through meta-analyzed 11 studies, our findings suggested that compared with nonusers, use of SSRIs was significantly associated with lumbar spine BMD reduction, particularly for old people. The use of selective serotonin reuptake inhibitors (SSRIs) has already been associated with bone mass loss. Their effects on bone mineral density (BMD) for the different bone sections have, however, thus been inconsistent...
February 12, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29435128/prognostic-factors-for-olfactory-groove-meningioma-with-nasal-cavity-extension
#9
Ji Zhang, Ke Sai, Zheng-Quan Zhu, Fu Hua Lin, Zi-Feng Wang, Yong-Ming Chen, Chun-Yu Huang, Yun-Lin Ye, Xiao-Li Wang, You-Ping Li, Shu-Xin Sun, Wei-Ying Zhong, Jian-Bin Chen, Yun-Qiang Yang
Objectives: Meningioma recurrence remains a significant issue. No study has described the relationship between the clinical features and prognosis of communicating meningioma that primarily originates from the olfactory groove. The aim of the study was to identify prognostic factors of communicating olfactory groove meningiomas that could be stratified according to their risk of recurrence. Results: A Simpson grade one or two resection was achieved. Complications with cerebrospinal rhinorrhoea occurred in two patients: one required reoperation, and the other was managed successfully with external drainage of lumbar cistern...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29434794/biomechanical-analysis-of-brachial-plexus-injury-availability-of-three-dimensional-finite-element-model-of-the-brachial-plexus
#10
Atsushi Mihara, Tsukasa Kanchiku, Norihiro Nishida, Haruki Tagawa, Junji Ohgi, Hidenori Suzuki, Yasuaki Imajo, Masahiro Funaba, Daisuke Nakashima, Xian Chen, Toshihiko Taguchi
Adult brachial plexus injuries frequently lead to significant and permanent physical disabilities. Investigating the mechanism of the injury using biomechanical approaches may lead to further knowledge with regard to preventing brachial plexus injuries. However, there are no reports of biomechanical studies of brachial plexus injuries till date. Therefore, the present study used a complex three-dimensional finite element model (3D-FEM) of the brachial plexus to analyze the mechanism of brachial plexus injury and to assess the validity of the model...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29433177/trabecular-anatomy-of-the-axis-vertebra-a-study-of-shaded-volume-rendered-computed-tomography-images
#11
K Venugopal Menon, Sameer B Raniga
BACKGROUND: To date, trabecular morphology studies have been conducted on thin-section computed tomography (CT) scans of cadaveric bone. Here we describe the trabecular anatomy of the axis vertebra as revealed by an innovative imaging tool. METHODS: Ten patients who underwent thin-slice CT scans for suspected cervical spine injury were prospectively subjected to shaded volume-rendered 3-dimensional reconstruction of the images. The trabecular anatomy thus depicted was recreated, and the mechanical vectors were deduced independently by a senior radiologist and spine surgeon and then matched...
February 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29433062/suppression-of-the-vestibular-short-latency-evoked-potential-by-electrical-stimulation-of-the-central-vestibular-system
#12
Christopher J Pastras, Ian S Curthoys, Ljiljana Sokolic, Daniel J Brown
In an attempt to view the effects of the efferent vestibular system (EVS) on peripheral dynamic vestibular function, we have monitored the Vestibular short-latency Evoked Potential (VsEP) evoked by pulses of bone conducted vibration during electrical stimulation of the EVS neurons near the floor of the fourth ventricle in the brainstem of anesthetized guinea pigs. Given the reported effects of EVS on primary afferent activity, we hypothesized that EVS stimulation would cause a slight reduction in the VsEP amplitude...
February 2, 2018: Hearing Research
https://www.readbyqxmd.com/read/29432502/comparison-of-the-effect-of-intravenous-anesthetics-used-for-anesthesia-during-electroconvulsive-therapy-on-the-hemodynamic-safety-and-the-course-of-ect
#13
REVIEW
Rafał Wojdacz, Łukasz Święcicki, Anna Antosik-Wójcińska
Electroconvulsive therapy (ECT) is the treatment method widely used in psychiatric disorders such as depression, bipolar disorder, schizophrenia and schizoaffective disorder. The advantage of ECT is therapeutic response that occurs significantly earlier than during pharmacotherapy. Initially ECTwas used without anesthesia. Then, in the 1950s procedures with general anesthesia were introduced to reduce the complications that may occur during a seizure caused by ECT, such as broken bones, teeth, tendon rupture, muscle damage...
December 30, 2017: Psychiatria Polska
https://www.readbyqxmd.com/read/29432319/are-variable-angle-locking-screws-stable-enough-to-prevent-calcaneal-articular-surface-collapse-a-biomechanical-study
#14
Martin C Jordan, Konrad Fuchs, Timo M Heintel, Hendrik Jansen, Stefanie Hoelscher-Doht, Rainer H Meffert
PURPOSE: To compare fixed- or variable-angle locking screws in calcaneal fracture plates using a sawbones biomechanical model. METHODS: Intra-articular calcaneal fractures were created in synthetic bones. Reduction and stabilization was performed with three different plates. In Group A, a fixed-angle locking plate was used with screws fastened perpendicularly to the plate (3.5 LCP, DePuySynthes). In Groups B and C (2.7 VA-LCP, DePuySynthes and 3.5 Aptus, Medartis, respectively), fracture fixation was performed using variable-angle locking plates...
February 9, 2018: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29430497/evaluation-of-bone-mineral-density-in-perimenopausal-period
#15
Zhaleh Shariati-Sarabi, Hamid Etemad Rezaie, Nasrin Milani, Farnaz Etemad Rezaie, Ali Etemad Rezaie
Background: The menopausal transition called perimenopause, happens after the reproductive years, and is specified with irregular menstrual cycles, perimenopause symptoms and hormonal changes. Women going through peri menopausal period are vulnerable to bone loss . Osteoporosis is one of the most common debilitating metabolic bone diseases, especially in the women almost around 50 years. This study was intended to evaluate the prevalence of osteopenia/osteoporosis amongst asymptomatic individuals during the menopause transition period...
January 2018: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/29429820/direct-bone-conduction-stimulation-ipsilateral-effect-of-different-transducer-attachments-in-active-transcutaneous-devices
#16
Cristina Rigato, Sabine Reinfeldt, Bo Håkansson, Karl-Johan Fredén Jansson, Erik Renvall, Måns Eeg-Olofsson
Active transcutaneous bone conduction devices, where the transducer is implanted, are used for rehabilitation of hearing impaired patients by directly stimulating the skull bone. The transducer and the way it is attached to the bone play a central role in the design of such devices. The actual effect of varying the contact to bone has not been addressed yet. The aim of this study is therefore to compare how different attachment methods of the transducer to the bone for direct stimulation affect the ear canal sound pressure and vibration transmission to the ipsilateral cochlea...
January 31, 2018: Hearing Research
https://www.readbyqxmd.com/read/29429762/enthesitis-a-hallmark-of-psoriatic-arthritis
#17
REVIEW
Gurjit S Kaeley, Lihi Eder, Sibel Z Aydin, Marwin Gutierrez, Catherine Bakewell
OBJECTIVE: To describe the growing importance of enthesitis in patients with psoriatic arthritis (PsA) and discuss the advantages and disadvantages of clinical and imaging methods currently used to assess enthesitis. METHODS: PubMed literature searches were conducted using the terms psoriatic arthritis, entheses, enthesitis, pathology, imaging, ultrasound, magnetic resonance imaging, clinical, and indices. Articles were deemed relevant if they provided insight into the pathology, monitoring, and/or diagnosis of enthesitis in PsA, or if they discussed clinical or imaging indices used to assess enthesitis...
January 6, 2018: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29429227/-effect-of-nerve-growth-factor-on-osteogenic-potential-of-type-2-diabetic-mice-bone-marrow-stromal-cell-in-vitro
#18
G S Cui, J Y Zeng, J Zhang, R Lu
Objective: To study the effects of nerve growth factor (NGF) on the proliferation, osteogenic differentiation and mineralization of type 2 diabetic mice bone marrow stromal cell (BMSC), providing basis for clinical application of NGF. Methods: Three 8-week-old male db/db mice and two 8-week-old male C57BL/6J mice were used in the study. BMSC derived from femur were cultured though adherence method. BMSC of C57BL/6J mice and db/db mice was divided into normal group and diabetic group to conduct the osteogenic potential experiment, named experiment one...
February 9, 2018: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/29428552/high-bone-mineral-density-in-sickle-cell-disease-prevalence-and-characteristics
#19
Gonzalo De Luna, Brigitte Ranque, Marie Courbebaisse, Jean-Antoine Ribeil, Djamal Khimoud, Sidonie Dupeux, Jonathan Silvera, Lucile Offredo, Jacques Pouchot, Jean-Benoît Arlet
BACKGROUND: Osteosclerosis (OSC) is a rarely studied complication of sickle cell disease (SCD). The objective of our study was to determine the prevalence and characteristics of high bone mineral density (BMD) and its radiological features in adult SCD patients. METHODS: This prospective observational study was conducted from May 2007 to May 2016 in consecutive patients with steady-state SCD at two university hospitals. The BMD of the lumbar spine (L1-L4) and right femoral neck was determined by dual energy X-ray absorptiometry...
February 8, 2018: Bone
https://www.readbyqxmd.com/read/29427218/short-to-mid-term-outcomes-of-anatomic-mcl-reconstruction-with-achilles-tendon-allograft-after-multiligament-knee-injury
#20
Ian J Barrett, Aaron J Krych, Ayoosh Pareek, Nicholas R Johnson, Diane L Dahm, Michael J Stuart, Bruce A Levy
PURPOSE: Multiple techniques have been described in the literature for reconstruction of the medial collateral ligament. The purpose of this study is to describe functional outcome, range of motion, and knee stability following anatomic MCL reconstruction utilizing an Achilles tendon bone allograft after multiligament knee injury. METHODS: A comprehensive search of a single-hospital multiligament knee injury (MLKI) procedural database was conducted to identify all patients that underwent reconstruction of the MCL utilizing an Achilles tendon bone allograft and with 2-year clinical follow-up...
February 9, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
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