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Pentaxin 3

Alireza Zandifar, Niloufar Iraji, Maryam Taheriun, Mohamadhasan Tajaddini, Shaghayegh Haghjooy Javanmard
BACKGROUND: Migraine is a common neurovascular disorder with multifactorial and polygenic inheritance. It has been shown that migraine may be a form of sterile neurogenic inflammation. Pentaxins 3 (PTX3) has been detected in brain during inflammatory responses. The aim of our study was to investigate the association of rs3816527 polymorphism of the PTX3 gene and migraine in an Iranian population. METHOD: We included 103 newly diagnosed migraine patients and 148 healthy subjects as control group...
February 15, 2015: Journal of the Neurological Sciences
Robert A J Oostendorp, Catherine Robin, Christine Steinhoff, Stefanie Marz, Rosalinde Bräuer, Ulrike A Nuber, Elaine A Dzierzak, Christian Peschel
We recently established that two midgestation-derived stromal clones--UG26-1B6, urogenital ridge-derived, and EL08-1D2, embryonic liver-derived--support the maintenance of murine adult bone marrow and human cord blood hematopoietic repopulating stem cells (HSCs). In this study, we investigate whether direct HSC-stroma contact is required for this stem cell maintenance. Adult bone marrow ckit+ Ly-6C- side population (K6-SP) cells and stromal cells were cocultured under contact or noncontact conditions. These experiments showed that HSCs were maintained for at least 4 weeks in culture and that direct contact between HSCs and stromal cells was not required...
June 2005: Stem Cells
F Breviario, E M d'Aniello, J Golay, G Peri, B Bottazzi, A Bairoch, S Saccone, R Marzella, V Predazzi, M Rocchi
Differential screening of a cDNA library constructed from human umbilical vein endothelial cells exposed for 1 h to interleukin-1 beta (IL-1 beta) has led to the identification of a novel gene (PTX3) related to pentaxins (C-reactive protein and serum amyloid P component in man), a subclass of acute phase proteins. Sequencing of the full-length cDNA clone and RNase mapping revealed that the PTX3 transcript is 1861 base pairs long and has a unique transcription start site. The predicted protein sequence of 381 amino acids is highly similar to pentaxins in its COOH-terminal half where it also contains a typical 8-amino acid "pentaxin signature" sequence...
November 5, 1992: Journal of Biological Chemistry
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