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Ovarian carcinomatosis

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https://www.readbyqxmd.com/read/28736743/oncolytic-adenovirus-loaded-menstrual-blood-stem-cells-overcome-the-blockade-of-viral-activity-exerted-by-ovarian-cancer-ascites
#1
Ana Laura Alfano, Alejandro Nicola Candia, Nicasio Cuneo, Leandro N Guttlein, Alejandro Soderini, Cecilia Rotondaro, Leonardo Sganga, Osvaldo L Podhajcer, M Veronica Lopez
Patients with ovarian cancer present peritoneal ascites at recurrence as a marker of disseminated disease and dismal prognosis. Oncolytic immunotherapy is an emerging approach for the treatment of disseminated cancer. In the present work, we constructed a novel oncolytic adenovirus, AR2011, to target malignant ovarian tumors. AR2011 exhibited a clear lytic effect in vitro in human ovarian cancer cell lines and malignant cells obtained from ascitic fluids (AFs) of patients with ovarian cancer. AR2011 activity was neutralized by antibodies present in 31 samples of patient-derived AFs...
September 15, 2017: Molecular Therapy Oncolytics
https://www.readbyqxmd.com/read/28720378/a-novel-technique-carbon-dioxide-gas-assisted-total-peritonectomy-diaphragm-and-intestinal-meso-stripping-in-open-surgery-for-advanced-ovarian-cancer-%C3%A3-ukurova-technique
#2
Ghanim Khatib, Ahmet Baris Guzel, Umran Kucukgoz Gulec, Mehmet Ali Vardar
OBJECTIVE: Most of the ovarian cancers are diagnosed at advanced stages. As peritoneal carcinomatosis increases, especially when it extends to the diaphragm and intestinal mesos, probability of obtaining complete cytoreduction is reduced. Complete cytoreduction (residue zero: R0) is one of the main factors affecting survival [1-3]. Here we present a novel technique of stripping the peritoneal surfaces as a part of cytoreductive surgery in such cases. METHODS: A 55year-old woman diagnosed with peritoneal carcinomatosis was considered appropriate for primary cytoreduction after assessment of her thorax-abdominopelvic tomography, which revealed resectable intra-abdominal disease...
July 15, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28704322/malignant-bowel-obstruction-in-relapsed-ovarian-cancer-with-peritoneal-carcinomatosis-an-occlusive-state
#3
Pedro Martinez Castro, Lara Vargas, Antonio Mancheño, Salvador Martín Utrilla, Francisco Pascual, Ignacio Romero, Cristina Zorrero, José Manuel Bosch, Andrés Poveda, Lucas Minig
OBJECTIVE: The aim of this study was to describe the clinical and oncological outcomes of women with malignant bowel obstruction (MBO) for relapsed ovarian cancer and peritoneal carcinomatosis. METHODS: A retrospective cohort study was performed in all consecutive patients admitted at Instituto Valenciano de Oncología, Valencia, Spain, between July 2013 and July 2016 with MBO for relapsed ovarian cancer and peritoneal carcinomatosis. All patients underwent the same protocol of conservative management...
July 12, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28668403/f-18-fdg-pet-ct-metabolic-tumor-volume-predicts-overall-survival-in-patients-with-disseminated-epithelial-ovarian-cancer
#4
Rosj Gallicchio, Anna Nardelli, Angela Venetucci, Daniela Capacchione, Alessandra Pelagalli, Cesare Sirignano, Pierpaolo Mainenti, Piernicola Pedicini, Giuseppe Guglielmi, Giovanni Storto
OBJECTIVE: We evaluated the prognostic impact of quantitative assessment by maximum standardized uptake value (SUVmax), metabolic tumour volume (MTV) and tumour lesion glycolysis (TLG) on [F-18] FDG PET/CT for patients with peritoneal carcinomatosis from epithelial ovarian cancer (EOC). METHODS: Thirty-one patients with EOC underwent PET/CT for an early restaging after cytoreductive surgery, having been diagnosed with carcinomatosis (before chemotherapy). The SUVmax, MTV (cm(3); 42% threshold) and TLG (g) were registered on residual peritoneal lesions...
August 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28659008/pain-mechanisms-in-peritoneal-diseases-might-be-partially-regulated-by-estrogen
#5
Clara Börner, Claudia Scheerer, Rene Buschow, Vito Chiantera, Jalid Sehouli, Sylvia Mechsner
To identify factors influencing the differential pain pathogenesis in peritoneal endometriosis (pEM) and peritoneal carcinomatosis in ovarian cancer (pOC), we undertook an experimental study. Tissue samples of 18 patients with pEM, 15 patients with pOC, and 15 unaffected peritoneums as controls were collected during laparoscopy or laparotomy. Immunohistochemical stainings were conducted to identify nerve fibers and neurotrophins in the tissue samples. Additionally, 23 pEM fluids, 25 pOC ascites fluids, and 20 peritoneal fluids of patients with myoma uteri as controls were collected...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28651922/peritoneal-carcinomatosis-in-primary-ovarian-cancer-ultrasound-detection-and-comparison-with-computed-tomography
#6
Zhenhong Qi, Yixiu Zhang, Qing Dai, Yu Xia, Yuxin Jiang
We retrospectively compared detection rates and consistency for diagnosis of peritoneal carcinomatosis (PC) of primary ovarian cancer (OC) between ultrasound (US) and computed tomography (CT) scans in 41 patients whose PC of OC (stages IIC-IV) had been diagnosed by histopathology findings. Compared with CT detection rates, those for US were significantly higher for metastases to the pelvic area (92.3% vs. 43.6%, p < 0.001) and bowel surface (64.0% vs. 16.0%, p = 0.002); however, they did not significantly differ for other sites: omentum, diaphragm, lateral peritoneum, mesenteric, hepatic and splenic surfaces...
June 23, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28649123/extraovarian-primary-peritoneal-carcinomatosis-a-case-report
#7
Gregory Nicolas, Tony Kfoury, Hassan Fawaz, Mahdi Issa
BACKGROUND Extraovarian primary peritoneal carcinoma (EOPPC) is a rare malignant epithelial tumor with an age-adjusted incidence rate of 6.78 per million, which arises from the peritoneal lining with minimal or no ovarian involvement. EOPPC is a diagnosis of exclusion with the absence of other identifiable primary sites and after surgical assessment and consideration of the histological report to evaluate the extent of ovarian invasion. CASE REPORT A 66-year-old woman complained of mild postprandial epigastric pain...
June 26, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28643069/lessons-learned-from-a-phase-ii-clinical-trial-of-laparoscopic-hipec-for-gastric-cancer
#8
Brian Badgwell, Mariela Blum, Prajnan Das, Jeannelyn Estrella, Xuemei Wang, Keith Fournier, Richard Royal, Paul Mansfield, Jaffer Ajani
BACKGROUND: Over the last two decades, intraperitoneal chemotherapy has been found to have activity for select subgroups of patients with carcinomatosis from colon, ovarian, appendiceal, and recently, gastric origins. However, there is little data to support an aggressive surgical approach of cytoreduction (debulking) and hyperthermic intraperitoneal perfusion with chemotherapy (HIPEC) for patients with gastric cancer and positive cytology or carcinomatosis. The morbidity and mortality rates of cytoreduction and HIPEC, in combination with gastrectomy, are significant and the survival rates of this approach may not extend beyond that of treatment with systemic chemotherapy...
June 22, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28626402/effect-of-the-combination-of-trabectedin-and-pegylated-liposomal-doxorubicin-in-a-brca2-mutation-carrier-with-recurrent-platinum-sensitive-ovarian-cancer
#9
María Jesús Rubio Pérez
INTRODUCTION: The current standard of care for ovarian cancer is optimal cytoreduction with adjuvant chemotherapy based on a platinum/taxane combination. Although the response rate to this therapy is high, most patients ultimately relapse. Response to second-line therapy and prognosis are linked to the platinum-free interval (PFI); when both improve, the PFI increases. As a result, there is an increasing interest in the PFI extension strategies including platinum-free combinations. CASE PRESENTATION: A 50-year-old postmenopausal woman presented with ovarian serous carcinoma with peritoneal carcinomatosis...
May 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28610414/role-of-galectin-3-combined-with-multi-detector-contrast-enhanced-computed-tomography-in-predicting-disease-recurrence-in-patients-with-ovarian-cancer
#10
Emanuela Anastasi, Silvia Gigli, Maria Santulli, Sara Tartaglione, Laura Ballesio, Maria Grazia Porpora, Teresa Granato, Carlo Catalano, Antonio Angeloni, Lucia Manganaro
Galectin-3 (Gal-3) is an endogenous β-galactoside-binding lectin, playing an important role in the pathogenesis of multiple malignancies. Aim of the study was to evaluate in a group of patients treated for ovarian cancer (EOC), the role of Gal-3 combined with multi-detector contrast-enhanced computed tomography (MDCT), as predictor of recurrence disease. Seventeen follow-up patients with recurrent ovarian cancer and 13 follow-up patients with stable ovarian disease, who performed MDCT at one-year follow-up after cytoreductive treatment, were enrolled...
May 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28603028/targeting-of-p32-in-peritoneal-carcinomatosis-with-intraperitoneal-lintt1-peptide-guided-pro-apoptotic-nanoparticles
#11
Hedi Hunt, Lorena Simón-Gracia, Allan Tobi, Venkata Ramana Kotamraju, Shweta Sharma, Mait Nigul, Kazuki N Sugahara, Erkki Ruoslahti, Tambet Teesalu
Gastrointestinal and gynecological malignancies disseminate in the peritoneal cavity - a condition known as peritoneal carcinomatosis (PC). Intraperitoneal (IP) administration can be used to improve therapeutic index of anticancer drugs used for PC treatment. Activity of IP anticancer drugs can be further potentiated by encapsulation in nanocarriers and/or affinity targeting with tumor-specific affinity ligands, such as tumor homing peptides. Here we evaluated a novel tumor penetrating peptide, linTT1 (AKRGARSTA), as a PC targeting ligand for nanoparticles...
June 8, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28551658/preoperative-ca-125-values-as-a-predictive-factor-for-the-postoperative-outcome-in-primary-serous-ovarian-cancer
#12
Mustafa Zelal Muallem, Asya Parashkevova, Jumana Almuheimid, Rolf Richter, Yasser Diab, Elena Ioana Braicu, Jalid Sehouli
BACKGROUND/AIM: The purpose of the study was to examine the preoperative CA-125 values as a predictive factor for postoperative outcome in primary serous ovarian cancer (POC) for complete tumor resection (CTR) and evaluate the preoperative CA-125 levels with other vital clinical dynamics such as ascites, lymph node involvement, diffuse peritoneal carcinomatosis, grading and staging. PATIENTS AND METHODS: A cohort of 277 POC-patients aged 18-75 years, who had undergone primary cytoreductive surgery at the Department of Gynecology & Oncological Surgery, Charité, Campus Virchow Klinikum (CVK) between 2000 und 2009 was analyzed in correlation with the preoperative CA-125 values...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28549831/adenocarcinoma-of-the-appendix-with-extra-appendicular-spread-clinico-surgical-and-histologic-analysis-of-27-cases
#13
Francisco J Morera Ocón, Bruno Camps Vilata, Elena Muñoz Forner, Clara Navarro Campoy, Javier Gallego Plazas, Samuel Navarro Fos
BACKGROUND AND OBJECTIVES: Appendiceal neoplasms with extra-appendiceal spread may show different clinical patterns with pseudomyxoma peritonei (PMP) being one of them. We analyse the results in a series of patients treated in our centre. MATERIAL AND METHODS: Retrospective study of patients operated on for appendiceal peritoneal carcinomatosis from January 2012 to May 2015. RESULTS: Twenty-seven consecutive patients were included. Median age 63 years (26-73); 14 were men...
May 23, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28546107/intestinal-toxicity-evaluation-of-long-circulating-and-ph-sensitive-liposomes-loaded-with-cisplatin
#14
Raquel Silva Araújo, Ana Letícia Malheiros Silveira, Éricka Lorenna de Sales E Souza, Rachel Horta Freire, Cristina Maria de Souza, Diego Carlos Reis, Bruno Rocha Cordeiro Costa, Michelle Amantéa Sugimoto, Josianne Nicácio Silveira, Flaviano Dos Santos Martins, Geovanni Dantas Cassali, Jacqueline Isaura Alvarez Leite, Lirlândia Pires Sousa, Adaliene Versiani Matos Ferreira, Mônica Cristina Oliveira, Valbert Nascimento Cardoso
Cisplatin (CDDP) is a chemotherapeutic agent widely used in several anticancer protocols for instance head and neck, testicle, ovarian, lung and peritoneal carcinomatosis. According to the literature, the use of CDDP is associated with several side effects; among them, we highlighted the mucositis. CDDP, when administered by IP, promoted significant intestinal epithelium alterations in an experimental model. Our research group has proposed that the incorporation of CDDP into long-circulating and pH-sensitive liposomes (SpHL-CDDP) could help to overcome some side effects induced by this drug...
August 30, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28540830/progress-in-the-management-of-primary-and-recurrent-ovarian-carcinomatosis-with-peritonectomy-procedure-and-hipec-in-a-high-volume-centre
#15
Alvaro Arjona-Sanchez, Sebastian Rufián-Peña
INTRODUCTION: The treatment of advanced primary or recurrent ephitelial ovarian cancer still remains an open and a critical question. The addition of HIPEC to cytoreductive surgery has shown improving overall survival rates. The aim of our study is to describe the progress in its management in our Unit and what we have learned after more than 350 HIPEC procedures. METHODS: From 1997 to 2016 we conducted a retrospective analysis from a prospective database. We described and analyzed 4 cut-points, 1997-2004, 2009, 2012 and 2016...
August 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28540777/acute-kidney-injury-in-ovarian-cancer-patients-undergoing-cytoreductive-surgery-and-hyperthermic-intra-peritoneal-chemotherapy
#16
Eliza I-Lin Sin, Claramae Shulyn Chia, Grace Hwei Ching Tan, Khee Chee Soo, Melissa Ching-Ching Teo
BACKGROUND: Cytoreductive surgery and hyperthermic intra-peritoneal chemotherapy (CRS-HIPEC) prolongs survival in patients with metastatic peritoneal disease. We look at the incidence of acute kidney injury (AKI) in patients who have received cisplatin during CRS-HIPEC in the treatment of peritoneal carcinomatosis from an ovarian primary, and identify possible peri-operative risk factors. METHODS: Between 2005 and 2013, we performed CRS-HIPEC on 47 patients with ovarian primaries and peritoneal metastasis...
March 5, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28491194/leptomeningeal-carcinomatosis-and-bilateral-internal-auditory-canal-metastases-from-ovarian-carcinoma
#17
Martin Krupa, Kathy Byun
Ovarian cancer, a leading cause of death in women, typically spreads locally and rarely metastasizes to the brain or seeds the leptomeninges. We present a case of a 62-year-old woman with a history of treated ovarian cell carcinoma who developed bilateral sensorineural deafness and right-sided facial weakness and on imaging was found to have bilateral internal auditory canal (IAC) masses and leptomeningeal carcinomatosis, pathologically proven by cerebrospinal fluid cytology. We discuss her magnetic resonance imaging and positron emission tomography-computed tomography findings and review the imaging characteristics of IAC metastases...
June 2017: Radiology case reports
https://www.readbyqxmd.com/read/28487593/ovarian-carcinomatosis-in-a-dog-managed-with-surgery-and-intraperitoneal-systemic-and-intrapleural-chemotherapy-utilizing-indwelling-pleural-access-ports
#18
Matthew P Best, Angela E Frimberger
A 3-year-old Weimaraner dog was presented with bilateral papillary ovarian carcinoma and abdominal carcinomatosis. Treatment included ovariectomy, intraperitoneal cisplatin, and systemic carboplatin. Pleural carcinomatosis 473 days following surgery was treated with intrapleural cisplatin through indwelling pleural access ports. Euthanasia occurred 1154 days following surgery due to malignant pleural effusion without peritoneal effusion.
May 2017: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/28483269/multiplex-profiling-identifies-distinct-local-and-systemic-alterations-during-intraperitoneal-chemotherapy-for-ovarian-cancer-an-nrg-oncology-gynecologic-oncology-group-study
#19
MULTICENTER STUDY
Shannon Grabosch, George Tseng, Robert P Edwards, Heather A Lankes, Kathleen Moore, Kunle Odunsi, Anda Vlad, Tianzhou Ma, Mary Strange, Joan Brozick, Amit Lugade, Angela Omilian, Wiam Bshara, Ashley R Stuckey, Joan L Walker, Michael Birrer
OBJECTIVES: Ovarian cancer leads to abdominal carcinomatosis and late stage (III/IV) diagnosis in 75% of patients. Three randomized phase III trials have demonstrated that intraperitoneal (IP) chemotherapy improves outcomes in epithelial ovarian cancer. While IP treatment is validated by clinical trials, there is a poor understanding of the mechanism(s) leading to the survival advantage other than the increased concentration of cytotoxic drugs within the tumor microenvironment. A better understanding of this process through analysis of dynamic biomarkers should promote novel approaches that may enhance tumor clearance...
July 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28465688/thrombopoietin-secretion-by-human-ovarian-cancer-cells
#20
Samaher Besbes, Shahid Shah, Iman Al-Dybiat, Shahsoltan Mirshahi, Helene Helfer, Haythem Najah, Caroline Fourgeaud, Marc Pocard, Ibtissem Ghedira, Jeannette Soria, Massoud Mirshahi
The thrombopoietin (TPO) gene expression in human ovary and cancer cells from patients with ovarian carcinomatosis, as well as several cancer cell lines including MDA-MB231 (breast cancer), K562 and HL60 (Leukemic cells), OVCAR-3NIH and SKOV-3 (ovarian cancer), was performed using RT PCR, real-time PCR, and gene sequencing. Human liver tissues are used as controls. The presence of TPO in the cells and its regulation by activated protein C were explored by flow cytometry. TPO content of cell extract as well as plasma of a patient with ovarian cancer was evaluated by ELISA...
2017: International Journal of Cell Biology
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