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Ovarian carcinomatosis

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https://www.readbyqxmd.com/read/29315498/peritoneal-carcinomatosis-after-risk-reducing-surgery-in-brca1-2-mutation-carriers
#1
Marline G Harmsen, Jurgen M J Piek, Johan Bulten, Murray J Casey, Timothy R Rebbeck, Marian J Mourits, Mark H Greene, Brigitte F M Slangen, Marc van Beurden, Leon F A G Massuger, Nicoline Hoogerbrugge, Joanne A de Hullu
BACKGROUND: Risk-reducing salpingo-oophorectomy (RRSO) is recommended for BRCA1/2 mutation carriers because of their increased risk of ovarian carcinoma. Despite RRSO, metachronous peritoneal carcinomatosis occasionally is diagnosed. METHODS: The literature was searched for BRCA1/2 mutation carriers with peritoneal carcinomatosis after risk-reducing surgery. The authors were asked for additional data. Clinical and histopathological data were descriptively analyzed...
January 9, 2018: Cancer
https://www.readbyqxmd.com/read/29312629/fluorescence-guided-surgery-for-cancer-patients-a-proof-of-concept-study-on-human-xenografts-in-mice-and-spontaneous-tumors-in-pets
#2
Eliane Mery, Muriel Golzio, Stephanie Guillermet, Didier Lanore, Augustin Le Naour, Benoît Thibault, Anne Françoise Tilkin-Mariamé, Elizabeth Bellard, Jean Pierre Delord, Denis Querleu, Gwenael Ferron, Bettina Couderc
Surgery is often the first treatment option for patients with cancer. Patient survival essentially depends on the completeness of tumor resection. This is a major challenge, particularly in cases of peritoneal carcinomatosis, where tumors are widely disseminated in the large peritoneal cavity. Any development to help surgeons visualize these residual cells would improve the completeness of the surgery. For non-disseminated tumors, imaging could be used to ensure that the tumor margins and the draining lymph nodes are free of tumor deposits...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29298538/residual-tumor-less-than-0-25-centimetres-and-positive-lymph-nodes-are-risk-factors-for-early-relapse-in-recurrent-ovarian-peritoneal-carcinomatosis-treated-with-cytoreductive-surgery-hipec-and-systemic-chemotherapy
#3
Alvaro Arjona-Sanchez, Sebastian Rufian-Peña, Manuel Artiles, Juan Manuel Sánchez-Hidalgo, Ángela Casado-Adam, Antonio Cosano, Heather Thoelecke, Sharmila Ramnarine, Dimas Garcilazo, Javier Briceño-Delgado
The cytoreductive surgery (CRS) and HIPEC has showed promising results for the survival in patients with recurrent ovarian carcinomatosis, however, some of them will recur within the first year. The aim of this study is focused on identifying the risk factors to develop the recurrence within the first year after an optimal CRS-HIPEC in patients with recurrent ovarian carcinomatosis. METHODS: A total of 100 patients with peritoneal carcinomatosis from recurrent ovarian cancer treated by CRS+HIPEC were selected for analysis...
January 3, 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29288614/laparoscopic-hipec-for-peritoneal-carcinomatosis-from-gastric-cancer-technique-and-early-outcomes-of-our-first-cases
#4
Irina Bălescu, Daniela Godoroja, Mircea Gongu, Victor Tomulescu, Cătălin Copăescu
Gastric cancer remains one of the most aggressive malignancies, being associated with very poor therapeutic outcomes, especially in the advanced disease patients. Due to this evidence, finding a better treatment, a better control and higher survival rates is the current scientific focus of the medical community. Once the benefits of cytoreductive surgery in association with intraperitoneal hyperthermy (HIPEC) have been widely demonstrated in patients presenting peritoneal carcinomatosis from colorectal or ovarian origin,attention was focused on the possible benefit of this method in patients diagnosed with peritoneal carcinomatosis with gastric origin...
November 2017: Chirurgia
https://www.readbyqxmd.com/read/29167313/mechanism-informed-repurposing-of-minocycline-overcomes-resistance-to-topoisomerase-inhibition-for-peritoneal-carcinomatosis
#5
Huang-Chiao Huang, Joyce Liu, Yan Baglo, Imran Rizvi, Sriram Anbil, Michael Pigula, Tayyaba Hasan
Mechanism-inspired drug repurposing that augments standard treatments offers a cost-effective and a rapid route toward addressing the burgeoning problem of plateauing of effective therapeutics for drug-resistant micrometastases. We show that the antibiotic minocycline, by its ability to minimize DNA repair via reduced expression of tyrosyl-DNA phosphodiesterase-1 (Tdp1), removes a key process attenuating the efficacy of irinotecan, a frequently used chemotherapeutic against metastatic disease. Moreover, minocycline and irinotecan cooperatively mitigate each other's undesired cytokine inductions of VEGF and IL-8 respectively, thereby reinforcing the benefits of each modality...
November 22, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29164988/development-of-peritoneal-carcinomatosis-in-epithelial-ovarian-cancer-a-review
#6
Juliette O A M van Baal, Cornelis J F van Noorden, Rienk Nieuwland, Koen K Van de Vijver, Auguste Sturk, Willemien J van Driel, Gemma G Kenter, Christianne A R Lok
Epithelial ovarian cancer (EOC) metastasizes intra-abdominally with often numerous, superficial, small-sized lesions. This so-called peritoneal carcinomatosis is difficult to treat, and peritoneal recurrences are frequently observed, leading to a poor prognosis. Underlying mechanisms of interactions between EOC and peritoneal cells are incompletely understood. This review summarizes and discusses the development of peritoneal carcinomatosis from a cell-biological perspective, focusing on characteristics of EOC and peritoneal cells...
November 1, 2017: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
https://www.readbyqxmd.com/read/29137284/treatment-strategy-and-prognostic-factors-for-krukenberg-tumors-of-gastric-origin-report-of-a-10-year-single-center-experience-from-china
#7
Pengfei Yu, Ling Huang, Guoping Cheng, Litao Yang, Gaiguo Dai, Jieer Ying, Yian Du
Background: Gastric cancer patient with ovarian metastasis is common in clinical practice, but it is still uncertain whether surgical resection of ovarian metastasis could improve the outcome. This study aimed to explore the survival benefit of metastasectomy plus chemotherapy over chemotherapy alone in the treatment of Krukenberg tumors arising from gastric cancer and to identify prognostic factors. Results: A total of 152 patients were identified, including 93 patients with synchronous ovarian metastasis and 59 patients with metachronous ovarian metastasis...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29121779/image-guided-surgery-in-gynecologic-oncology
#8
Henri Azaïs, Geoffroy Canlorbe, Yohan Kerbage, Anne Grabarz, Pierre Collinet, Serge Mordon
Image-guided surgery is a relevant way to reduce surgical morbidity and maximize cytoreductive surgery approach especially in ovarian cancer. Sentinel lymph node detection is a promising approach to avoid radical lymph node dissection and is slightly becoming standard in daily practice in endometrial and cervical cancer surgery even if it needs to be evaluated more precisely. Regarding carcinomatosis of ovarian origin, detection and treatment of microscopic disease could be appropriate to avoid local recurrences...
November 10, 2017: Future Oncology
https://www.readbyqxmd.com/read/29117194/a-pre-operative-predictive-score-to-evaluate-the-feasibility-of-complete-cytoreductive-surgery-in-patients-with-epithelial-ovarian-cancer
#9
Marion Chesnais, Fabrice Lecuru, Myriam Mimouni, Charlotte Ngo, Arnaud Fauconnier, Cyrille Huchon
OBJECTIVE: Postoperative residual tumor is the major prognostic factor in ovarian cancer. The feasibility of complete cytoreductive surgery is assessed by laparoscopy. Our goal was to develop a predictive score prior to laparoscopy to evaluate the feasibility of complete cytoreductive surgery in patients with epithelial ovarian cancer. METHODS: We developed a score to predict incomplete cytoreductive surgery by performing multiple logistic regressions after bootstrap procedures on data from a retrospective cohort of 247 patients with advanced ovarian cancer...
2017: PloS One
https://www.readbyqxmd.com/read/29108718/a-new-animal-model-for-hyperthermic-intraperitoneal-chemotherapy-hipec-in-tumor-bearing-mice-in-the-treatment-of-peritoneal-carcinomatosis-of-ovarian-origin
#10
G Miailhe, A Arfi, M Mirshahi, C Eveno, M Pocard, C Touboul
AIM OF THE STUDY: We set out to develop and evaluate the morbidity of a non-invasive hyperthermic intraperitoneal chemotherapy (HIPEC) procedure in mice. HIPEC has been shown to improve overall survival in treating ovarian cancer with peritoneal carcinomatosis. However, related complications, toxicity and the lack of randomized trials limits its widespread use. To improve the surgical technique, there is a need for animal models that allow teams to work on large groups without burdensome logistics...
November 3, 2017: Journal of Visceral Surgery
https://www.readbyqxmd.com/read/29079180/mixed-endometrial-carcinomas-with-a-low-grade-serous-like-component-a-clinicopathologic-immunohistochemical-and-molecular-genetic-study
#11
Iñigo Espinosa, Emanuela D'Angelo, Marina Corominas, Alan Gonzalez, Jaime Prat
Recently, we reported 2 mixed endometrioid endometrial carcinomas with a low-grade serous-like component which doesn't fit into any of the 4 molecular groups described by The Cancer Genome Atlas (TCGA). In order to understand the nature of these tumors, we have done an immunohistochemical and molecular genetic study of these two cases and added a third case. Immunoreactivity for p53, ER, Ki67, WT1, MLH1, PMS2, MSH2, and MSH6 were assessed. Targeted next-generation sequencing for somatic mutations, including genes commonly implicated in carcinogenesis including TP53, KRAS, and PIK3CA, and Sanger sequencing for PTEN and POLE were also performed...
October 24, 2017: Human Pathology
https://www.readbyqxmd.com/read/29033584/dna-ploidy-and-s-phase-fraction-analysis-in-peritoneal-carcinomatosis-from-ovarian-cancer-correlation-with-clinical-pathological-factors-and-response-to-chemotherapy
#12
Silvia Carloni, Giulia Gallerani, Anna Tesei, Emanuela Scarpi, Giorgio Maria Verdecchia, Salvatore Virzì, Francesco Fabbri, Chiara Arienti
OBJECTIVE: We investigated the correlation between ploidy or S-phase fraction (SPF) and the clinical pathological characteristics of patients with peritoneal carcinomatosis from ovarian cancer. We also assessed their relation with the in vivo and in vitro response to several chemotherapeutic agents. PATIENTS AND METHODS: Fifty-three patients with peritoneal carcinomatosis from ovarian cancer were enrolled. Frozen tumor tissue was dissociated by a detergent-trypsin method, and the resulting cell suspension was stained with RNase A and propidium iodide...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28964609/multicentric-initial-experience-with-the-use-of-the-pressurized-intraperitoneal-aerosol-chemotherapy-pipac-in-the-management-of-unresectable-peritoneal-carcinomatosis
#13
MULTICENTER STUDY
Mohammad Alyami, Johan Gagniere, Olivia Sgarbura, Delphine Cabelguenne, Laurent Villeneuve, Denis Pezet, Francois Quenet, Olivier Glehen, Naoual Bakrin, Guillaume Passot
BACKGROUND: PIPAC is a recent approach for intraperitoneal chemotherapy with promising results for patients with peritoneal carcinomatosis (PC). We aimed to evaluate the postoperative outcome of PIPAC in patients with non-resectable PC during our initial experience of the technique. METHODS: All patients who underwent PIPAC for non-resectable PC in three centers were analyzed regarding postoperative outcomes. RESULTS: Seventy-three patients underwent 164 PIPAC...
November 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28888540/feasibility-safety-and-clinical-outcomes-of-cardiophrenic-lymph-node-resection-in-advanced-ovarian-cancer
#14
Renee A Cowan, Jill Tseng, Vijayashree Murthy, Radhika Srivastava, Kara C Long Roche, Oliver Zivanovic, Ginger J Gardner, Dennis S Chi, Bernard J Park, Yukio Sonoda
OBJECTIVES: Surgical resection of enlarged cardiophrenic lymph nodes (CPLNs) in primary treatment of advanced ovarian cancer has not been widely studied. We report on a cohort of patients undergoing CPLN resection during primary cytoreductive surgery (CRS), examining its feasibility, safety, and potential impact on clinical outcomes. METHODS: We identified all patients undergoing primary CRS/CPLN resection for Stages IIIB-IV high-grade epithelial ovarian cancer at our institution from 1/2001-12/2013...
November 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28874817/armored-car-t-cells-enhance-antitumor-efficacy-and-overcome-the-tumor-microenvironment
#15
Oladapo O Yeku, Terence J Purdon, Mythili Koneru, David Spriggs, Renier J Brentjens
Chimeric antigen receptor (CAR) T cell therapy has shown limited efficacy for the management of solid tumor malignancies. In ovarian cancer, this is in part due to an immunosuppressive cytokine and cellular tumor microenvironment which suppresses adoptively transferred T cells. We engineered an armored CAR T cell capable of constitutive secretion of IL-12, and delineate the mechanisms via which these CAR T cells overcome a hostile tumor microenvironment. In this report, we demonstrate enhanced proliferation, decreased apoptosis and increased cytotoxicity in the presence of immunosuppressive ascites...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28862207/effectiveness-of-intraperitoneal-or-intrapleural-administration-of-triamcinolone-acetonide-for-the-control-of-malignant-ascites-and-pleural-effusion-kansai-clinical-oncology-group-g1102-study
#16
Kimihiko Ito, Hiroshi Tsubamoto, Kayo Inoue, Yukari Miyoshi, Yoshihiro Ito, Kensuke Hori
OBJECTIVES: We conducted a retrospective multi-institutional study to evaluate the efficacy and toxicity of intraperitoneal or intrapleural triamcinolone acetonide (TA), a slowly metabolized corticosteroid administration for the management of malignant ascites or pleural effusion. MATERIALS AND METHODS: The medical records of patients with gynecologic cancer who were treated with paracentesis or thoracocentesis followed by administration of 400 mg of TA between 2005 and 2014 were reviewed...
July 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28855982/peritoneal-metastases-of-rare-carcinomas-treated-with-cytoreductive-surgery-and-hipec-a-single-center-case-series
#17
Andreas Brandl, Christina Barbara Zielinski, Wieland Raue, Johann Pratschke, Beate Rau
INTRODUCTION: In selected cases, cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is an established treatment for patients suffering from peritoneal metastases from colorectal, ovarian, gastric or appendiceal origin. The effectiveness of this extensive has not been elucidated within other rare diseases by now. METHODS: We conducted a retrospective analysis of patients treated with CRS for peritoneal carcinomatosis during the period between July 2010 and September 2015...
October 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28791387/atelocollagen-mediated-in-vivo-sirna-transfection-in-ovarian-carcinoma-is-influenced-by-tumor-site-sirna-target-and-administration-route
#18
Matthieu Meryet-Figuière, Charlotte Lecerf, Emilie Varin, Jean-Luc Coll, Marie-Hélène Louis, Soizic Dutoit, Florence Giffard, Cécile Blanc-Fournier, Siham Hedir, Nicolas Vigneron, Emilie Brotin, Laurent Pelletier, Véronique Josserand, Christophe Denoyelle, Laurent Poulain
Ovarian cancer is the leading cause of death from gynecological malignancies worldwide, and innate or acquired chemoresistance of ovarian cancer cells is the major cause of therapeutic failure. It has been demonstrated that the concomitant inhibition of Bcl-xL and Mcl-1 anti-apoptotic activities is able to trigger apoptosis in chemoresistant ovarian cancer cells. In this context, siRNA-mediated Bcl‑xL and Mcl-1 inhibition constitutes an appealing strategy by which to eliminate chemoresistant cancer cells...
October 2017: Oncology Reports
https://www.readbyqxmd.com/read/28790552/sister-mary-joseph-nodule-in-an-ovary-adenocarcinoma
#19
Selma Poparic, Asja Prohic, Suada Kuskunovic-Vlahovljak, Emir Guso, Aida Kapetanovic
INTRODUCTION: Sister Mary Joseph Nodule (SMJN) is a metastatic umbilical lesion secondary to a primary malignancy of any viscera, stomach and colon being most common in men, and ovary in women. CASE REPORT: In this article, we present the case of SMJN in a 54-year old female patient. An urgent diagnostic workup was performed with a computerized tomography of abdominal cavity and pelvis showing an expansive tumorous formation covering uterus with a carcinomatosis of peritoneum...
April 2017: Medical Archives
https://www.readbyqxmd.com/read/28772202/the-role-of-surgical-excision-for-the-krukenberg-tumour-a-case-report
#20
David Lam, Eugene Ong
INTRODUCTION: Krukenberg tumour (KT), which represents carcinoma in the ovary, is an uncommon manifestation of metastatic colorectal cancer. It is associated with poor prognosis and a high incidence of peritoneal metastatic disease. PRESENTATION OF CASE: The authors present a case of a 51-year-old female who had a symptomatic, metachronous right ovarian KT diagnosed 12 months after her initial resection. Surgery was performed to excise the 23cm tumour as well as the contralateral ovary and isolated peritoneal disease, with an R0 resection achieved...
2017: International Journal of Surgery Case Reports
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