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Ovarian carcinomatosis

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https://www.readbyqxmd.com/read/27906723/safety-and-outcome-measures-of-first-in-human-intraperitoneal-%C3%AE-radioimmunotherapy-with-212pb-tcmc-trastuzumab
#1
Ruby F Meredith, Julien J Torgue, Tania A Rozgaja, Eileen P Banaga, Patty W Bunch, Ronald D Alvarez, J Michael Straughn, Michael C Dobelbower, Andrew M Lowy
PURPOSE: One-year monitoring of patients receiving intraperitoneal (IP) Pb-TCMC-trastuzumab to provide long-term safety and outcome data. A secondary objective was to study 7 tumor markers for correlation with outcome. METHODS: Eighteen patients with relapsed intra-abdominal human epidermal growth factor receptor-2 expressing peritoneal metastases were treated with a single IP infusion of Pb-TCMC-trastuzumab, delivered <4 h after 4 mg/kg IV trastuzumab. Seven tumor markers were studied for correlation with outcome...
November 30, 2016: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27900846/plasmablastic-lymphoma-mimicking-carcinomatosis-a-case-report-and-review-of-the-literature
#2
Andrea M Olofson, Eric Y Loo, Paul A Hill, Xiaoying Liu
First identified as a distinct disease entity in HIV-positive patients, plasmablastic lymphoma is a rare aggressive disease which arises predominantly in men and is associated with immunodeficiency of all causes. Although its exact etiology is poorly understood, Epstein-Barr virus infection and MYC gene aberrations have been implicated in its development in both HIV-positive and HIV-negative patients. The disease typically involves extranodal sites with a predilection for the oral cavity but may occur in other locations...
November 30, 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27874958/diagnostic-accuracy-of-mdct-in-the-evaluation-of-patients-with-peritoneal-carcinomatosis-from-ovarian-cancer-is-delayed-enhanced-phase-really-effective
#3
E Rodolfino, E Devicienti, M Miccò, A Del Ciello, S E Di Giovanni, M Giuliani, C Conte, B Gui, A L Valentini, L Bonomo
OBJECTIVE: To assess the diagnostic accuracy of delayed enhanced phase in addition to portal enhanced phase in MDCT imaging for depicting peritoneal carcinomatosis (PC) implants in patients with ovarian cancer. PATIENTS AND METHODS: We retrospectively reviewed double-phase, portal enhanced phase (PEP) and delayed enhanced phase (DEP), MDCT-examinations of 40 patients with clinical suspicion of recurrent PC from histopathologically-proven ovarian cancer, previously treated with both cytoreductive surgery and adjuvant/neoadjuvant chemotherapy...
November 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27855557/201-consecutive-cytoreductive-surgery-crs-and-hyperthermic-intraperitoneal-chemotherapy-hipec-procedures-in-a-single-asian-tertiary-centre
#4
Grace Tan, Claramae Chia, Mrinal Kumar, Su Pin Choo, John Chia, Chee Kian Tham, Khee Chee Soo, Melissa Teo
INTRODUCTION: Peritoneal carcinomatosis (PC) is increasingly being treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). We provide a review of a high-volume Asian institute's experience and survival outcomes with this procedure. METHODS: Data was prospectively collected from 201 consecutive CRS and HIPEC procedures performed in a single institution between April 2001 and November 2015. Our primary endpoints were OS and DFS, and secondary endpoints were morbidity and mortality...
November 17, 2016: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/27807188/autophagy-induction-results-in-enhanced-anoikis-resistance-in-models-of-peritoneal-disease
#5
James L Chen, Jason David, Douglas Cook-Spaeth, Sydney Casey, David Cohen, Karuppaiyah Selvendiran, Tanios Bekaii-Saab, John Hays
: Peritoneal carcinomatosis and peritoneal sarcomatosis (PC/PS) is a potential complication of nearly all solid tumors and results in profoundly increased morbidity and mortality. Despite the ubiquity of PC/PS, there are no clinically relevant targeted therapies for either its treatment or prevention. To identify potential therapies, we developed in vitro models of PC/PS using tumor cell lines and patient-derived spheroids (PDS) that recapitulate anoikis resistance and spheroid proliferation across multiple cancer types...
November 2, 2016: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/27751625/paraneoplastic-systemic-sclerosis-about-3-cases-and-review-of-literature
#6
J-B Monfort, I Lazareth, P Priollet
OBJECTIVE: Association between cancer and systemic sclerosis (SSc) has been described. However, paraneoplastic SSc is not well known. The aim of this article is to describe cases of paraneoplastic systemic sclerosis and to compare them to other cases of the literature, to find characteristics that can make suspect a paraneoplastic mechanism when SSc is diagnosed. METHODS: We retrospectively analyzed patients, in our department who, over the last 15 years, presented with Raynaud's phenomenon with a diagnosis of SSc (including cancer during the period of SSc)...
October 14, 2016: Journal des Maladies Vasculaires
https://www.readbyqxmd.com/read/27743737/total-parietal-peritonectomy-with-en-bloc-pelvic-resection-for-advanced-ovarian-cancer-with-peritoneal-carcinomatosis
#7
Hee Seung Kim, Robert E Bristow, Suk-Joon Chang
OBJECTIVE: The majority of advanced ovarian cancer patients have peritoneal carcinomatosis involving from the pelvis to upper abdomen, which is a major obstacle to optimal cytoreduction. Since total parietal peritonectomy was introduced for treating peritoneal carcinomatosis from colorectal cancer [3], similar surgical techniques including pelvic peritonectomy have been applied in advanced ovarian cancer with peritoneal carcinomatosis [1], and these can increase the rate of complete cytoreduction up to 60% [2]...
December 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27734552/imaging-diagnosis-computed-tomography-findings-in-a-case-of-metastatic-ovarian-adenocarcinoma-in-a-dog
#8
Conor Rowan, Laura Cuddy, Jill Bryan, Robert Shiel, Séamus Hoey
A 5-year-old female entire German Shepherd presented for otitis and lethargy. An incidental abdominal mass was identified on examination. Ultrasound examination (US) identified a heterogeneous left ovarian mass. Computed tomography (CT) was performed for surgical planning and staging. The reproductive tract was removed en bloc and submitted for histopathology. Multiple small (1-5 mm) nodules identified at coeliotomy on the surface of the liver, spleen and peritoneum were biopsied. The lesions were not visible on CT nor US on review...
October 13, 2016: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/27666623/use-of-18-f-fdg-pet-ct-in-the-preoperative-evaluation-of-patients-diagnosed-with-peritoneal-carcinomatosis-of-ovarian-origin-candidates-to-cytoreduction-and-hipec-a-pending-issue
#9
V Lopez-Lopez, P A Cascales-Campos, J Gil, L Frutos, R J Andrade, M Fuster-Quiñonero, E Feliciangeli, E Gil, P Parrilla
PURPOSE: To evaluate the clinical usefulness of the results obtained with (18)F-FDG PET/CT in relation to CT in the preoperative staging of patients with peritoneal carcinomatosis secondary to primary or recurrent ovarian cancer candidates to cytoreductive surgery and hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC). MATERIAL AND METHODS: A retrospective study comparing the results obtained with CT and (18)F-FDG PET/CT in the preoperative evaluation of a series of 59 patients was performed...
October 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/27663731/improved-i-p-drug-delivery-with-bioadhesive-nanoparticles
#10
Yang Deng, Fan Yang, Emiliano Cocco, Eric Song, Junwei Zhang, Jiajia Cui, Muneeb Mohideen, Stefania Bellone, Alessandro D Santin, W Mark Saltzman
The i.p. administration of chemotherapy in ovarian and uterine serous carcinoma patients by biodegradable nanoparticles may represent a highly effective way to suppress peritoneal carcinomatosis. However, the efficacy of nanoparticles loaded with chemotherapeutic agents is currently hampered by their fast clearance by lymphatic drainage. Here, we show that a unique formulation of bioadhesive nanoparticles (BNPs) can interact with mesothelial cells in the abdominal cavity and significantly extend the retention of the nanoparticles in the peritoneal space...
October 11, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27636249/ct-differentiation-of-female-peritoneal-tuberculosis-and-peritoneal-carcinomatosis-from-normal-sized-ovarian-cancer
#11
Sang Woo Shim, Shang Hun Shin, Woon Jung Kwon, Yoong Ki Jeong, Jong Hwa Lee
OBJECTIVE: The purpose of this study was to analyze the computed tomography (CT) features of female peritoneal tuberculosis and peritoneal carcinomatosis from normal-sized ovarian cancer for their differentiation. MATERIALS AND METHODS: We analyzed the CT features of 18 female peritoneal tuberculosis and 17 peritoneal carcinomatosis with proven normal-sized ovarian carcinomas. Omental change, mesenteric change, parietal peritoneal thickening, lymph node enlargement, ascites, ovarian CT attenuation, and ovarian capsular change were analyzed...
September 16, 2016: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/27633094/usefulness-of-thermographic-analysis-to-control-temperature-homogeneity-in-the-development-and-implementation-of-a-closed-recirculating-co2-chemohyperthermia-model
#12
David Padilla-Valverde, Susana Sanchez-Garcia, Esther García-Santos, Carlos Marcote-Ibañez, Mercedes Molina-Robles, Jesús Martín-Fernández, Pedro Villarejo-Campos
PURPOSE: To determine the effectiveness of thermography to control the distribution of abdominal temperature in the development of a closed chemohyperthermia model Materials and Methods: For thermographic analysis, we divided the abdominopelvic cavity into nine regions according to a modification of carcinomatosis peritoneal index. A difference of 2.5º C between and within the quadrants, and thermographic colors, were used as asymmetric criteria. Preclinical study: Rats Model: Six athymic nude rats, male, rnu/rnu...
September 16, 2016: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/27631392/exploring-the-hydration-method-for-loading-sirna-on-liposomes-the-interplay-between-stability-and-biological-activity-in-human-undiluted-ascites-fluid
#13
George R Dakwar, Kevin Braeckmans, Wim Ceelen, Stefaan C De Smedt, Katrien Remaut
Delivery of small interfering RNA (siRNA) is recently gaining tremendous attention for the treatment of ovarian cancer. The present study investigated the potential of different liposomal formulations composed of (2,3-dioleoyloxy-propyl)-trimethylammonium (DOTAP) and 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) encapsulating siRNA (hydration method) for their ability to knockdown luciferase (Luc) activity in human ovarian cancer SKOV-3 cells. Fluorescence single particle tracking (fSPT) and fluorescence correlation spectroscopy (FCS) in human-undiluted ascites fluid obtained from a peritoneal carcinomatosis patient revealed that cationic hydra-lipoplexes (HYDRA-LPXs) and HYDRA-LPXs decorated with stable DSPE-PEG (DSPE HYDRA-LPXs) showed high stability during at least 24 h...
September 8, 2016: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/27612856/mesothelial-cells-interact-with-tumor-cells-for-the-formation-of-ovarian-cancer-multicellular-spheroids-in-peritoneal-effusions
#14
Isabelle Matte, Clara Major Legault, Perrine Garde-Granger, Claude Laplante, Paul Bessette, Claudine Rancourt, Alain Piché
Epithelial ovarian cancer (EOC) dissemination is primarily mediated by the shedding of tumor cells from the primary site into ascites where they form multicellular spheroids that rapidly lead to peritoneal carcinomatosis. While the clinical importance and fundamental role of multicellular spheroids in EOC is increasingly appreciated, the mechanisms that regulate their formation and dictate their cellular composition remain poorly characterized. To investigate these important questions, we characterized spheroids isolated from ascites of women with EOC...
December 2016: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/27611447/timing-and-patterns-of-recurrence-in-epithelial-ovarian-cancer-patients-with-no-gross-residual-disease-after-primary-debulking-surgery
#15
E Sun Paik, Yoo-Young Lee, Minhee Shim, Hyun Jin Choi, Tae-Joong Kim, Chel Hun Choi, Jeong-Won Lee, Byoung-Gie Kim, Duk-Soo Bae
OBJECTIVE: The aim of this study was to analyse patterns and timing of recurrence and their association with clinical outcomes in recurrent epithelial ovarian cancer (EOC) patients with no gross residual disease after primary debulking surgery (PDS). METHODS: This study was conducted on 303 EOC patients with no residual disease after PDS who were treated at the Samsung Medical Center from 2002 to 2012. By reviewing electronic medical records, information on date of clinical/pathological recurrence and pattern of disease presentation for each relapse were retrieved...
December 2016: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/27585490/whole-body-diffusion-weighted-magnetic-resonance-imaging-in-the-diagnosis-of-recurrent-ovarian-cancer-a-clinical-feasibility-study
#16
Katrijn L M Michielsen, Ignace Vergote, Raphaëla Dresen, Katya Op de Beeck, Ragna Vanslembrouck, Frédéric Amant, Karin Leunen, Philippe Moerman, Steffen Fieuws, Frederik De Keyzer, Vincent Vandecaveye
OBJECTIVE: To assess the clinical feasibility of whole-body diffusion-weighted MRI (WB-DWI/MRI) for diagnosis and prediction of complete tumour resection in patients with suspected recurrent ovarian cancer. METHODS: 51 females clinically suspected for ovarian cancer recurrence underwent 3-T WB-DWI/MRI in addition to contrast-enhanced CT. WB-DWI/MRI was assessed for detection of tumour recurrence, prediction of tumour extent and complete resection compared with CT...
September 21, 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27566040/is-complete-cytoreductive-surgery-feasible-in-this-patient-with-ovarian-cancer
#17
Anne-Lucie Dessapt, Cyrille Huchon, Charlotte Ngo, Anne-Sophie Bats, Chérazade Bensaid, Fabrice Lecuru
BACKGROUND: Post-operative residual tumor size is the main prognostic factor in advanced epithelial ovarian cancer. Our objective was to develop a score for predicting the feasibility of complete cytoreductive surgery in patients with advanced epithelial ovarian cancer. MATERIAL AND METHODS: Using data from a retrospective cohort of 123 patients with advanced ovarian cancer, we developed a score for predicting complete cytoreductive surgery, by performing multiple logistic regression after a jackknife procedure...
September 2016: Surgical Oncology
https://www.readbyqxmd.com/read/27552404/oncologic-safety-of-laparoscopy-in-the-surgical-treatment-of-type-ii-endometrial-cancer
#18
Giovanni Favero, Cristina Anton, Xin Le, Alexandre Silva E Silva, Nasuh Utku Dogan, Tatiana Pfiffer, Christhardt Köhler, Edmund Chada Baracat, Jesus Paula Carvalho
BACKGROUND: Laparoscopy is considered the method of choice in the operative treatment of type I endometrial carcinoma (EC). However, there is a paucity of data regarding the safety of endoscopy for type II EC because these malignancies have several biological similarities with ovarian cancer. OBJECTIVES: This study aimed to evaluate the feasibility, operative outcomes, and oncologic safety of laparoscopic surgery in patients with type II EC. METHODS: A retrospective study with histologically confirmed serous or clear-cell EC without peritoneal carcinomatosis treated by laparoscopy (G1) or laparotomy (G2) was conducted...
August 22, 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27528037/preclinical-activity-of-melflufen-j1-in-ovarian-cancer
#19
Charlotte Carlier, Sara Strese, Kristina Viktorsson, Ebba Velander, Peter Nygren, Maria Uustalu, Therese Juntti, Rolf Lewensohn, Rolf Larsson, Jack Spira, Elly De Vlieghere, Wim P Ceelen, Joachim Gullbo
Ovarian cancer carries a significant mortality. Since symptoms tend to be minimal, the disease is often diagnosed when peritoneal metastases are already present. The standard of care in advanced ovarian cancer consists of platinum-based chemotherapy combined with cytoreductive surgery. Unfortunately, even after optimal cytoreduction and adjuvant chemotherapy, most patients with stage III disease will develop a recurrence. Intraperitoneal administration of chemotherapy is an alternative treatment for patients with localized disease...
August 9, 2016: Oncotarget
https://www.readbyqxmd.com/read/27488213/use-of-plasmajet-for-peritoneal-carcinomatosis-in-ovarian-cancer
#20
Enrico Panuccio, Karin Leunen, Els Van Nieuwenhuysen, Patrick Neven, Sandrina Lambrechts, Ignace Vergote
OBJECTIVE: This study aimed to assess the role and complications of extensive cytoreduction with PlasmaJet (Plasma Surgical, Roswell, Ga) in ovarian cancer with peritoneal carcinomatosis. MATERIALS: All patients undergoing primary, secondary, or interval debulking surgery for ovarian cancer and treated with PlasmaJet between October 2013 and February 2015 were analyzed. RESULTS: Nineteen patients were enrolled. The median operative time was 270 minutes, median blood loss was 700 mL, and median length of stay was 9 days...
October 2016: International Journal of Gynecological Cancer
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