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https://www.readbyqxmd.com/read/29679907/in-vitro-screening-homology-modeling-and-molecular-docking-studies-of-some-pyrazole-and-imidazole-derivatives
#1
Farid Abrigach, Yahya Rokni, Abdelilah Takfaoui, Mohamed Khoutoul, Henri Doucet, Abdeslam Asehraou, Rachid Touzani
A series of synthesized compounds based on pyrazole and imidazole skeletons prepared by palladium catalysts via a one-pot reaction was screened to determine their inhibitory potency against the pathogen fungus Fusarium oxysporum f.sp. albedinis (F.o.a) and four bacteria strains namely Micrococcus luteus, Bacillus subtilis, Staphylococcus aureus and Escherichia coli. The obtained result showed that these compounds exhibit an efficiency antifungal action. Whereas, they showed a very weak antibacterial activity...
April 18, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29679465/generating-anchors-only-to-lose-them-the-unusual-story-of-glycosylphosphatidylinositol-anchor-biosynthesis-and-remodeling-in-yeast-and-fungi
#2
REVIEW
Sneha Sudha Komath, Sneh Lata Singh, Vavilala A Pratyusha, Sudisht Kumar Sah
Glycosylphosphatidylinositol (GPI)-anchored proteins (GPI-APs) are present ubiquitously at the cell surface in all eukaryotes. They play a crucial role in the interaction of the cell with its external environment, allowing the cell to receive signals, respond to challenges, and mediate adhesion. In yeast and fungi, they also participate in the structural integrity of the cell wall and are often essential for survival. Roughly four decades after the discovery of the first GPI-APs, this review provides an overview of the insights gained from studies of the GPI biosynthetic pathway and the future challenges in the field...
May 2018: IUBMB Life
https://www.readbyqxmd.com/read/29679119/the-role-of-iron-competition-in-the-antagonistic-action-of-the-rice-endophyte-streptomyces-sporocinereus-osish-2-against-the-pathogen-magnaporthe-oryzae
#3
Jiarui Zeng, Ting Xu, Lidan Cao, Chunyi Tong, Xuan Zhang, Dingyi Luo, Shuping Han, Pei Pang, Weibin Fu, Jindong Yan, Xuanming Liu, Yonghua Zhu
Rice blast caused by Magnaporthe oryzae severely impacts global rice yield stability. The rice endophyte Streptomyces sporocinereus OsiSh-2, with strong antagonistic activity towards M. oryzae, has been reported in our previous study. To decipher the model of the antagonistic action of OsiSh-2 towards M. oryzae, we compared the iron-capturing abilities of these two strains. The cultivation of OsiSh-2 and a M. oryzae strain under iron-rich and iron-starved conditions showed that M. oryzae depended more on iron supplementation for growth and development than did OsiSh-2...
April 20, 2018: Microbial Ecology
https://www.readbyqxmd.com/read/29678697/intra-cranial-cryptococcoma-clinicopathological-correlation-and-surgical-outcome-a-single-institute-experience
#4
Alok Uppar, A R Prabhu Raj, Subhas Konar, Sandeep K, Dhaval Shukla, Sampath Somanna, B Indira Devi, Yasha C, Nagarathna Chandrashekar
OBJECTIVE: The present case series describes the clinical characteristics of patients diagnosed with intra cranialcryptococcoma(ICC), the clinic-pathological correlation and the outcomes following surgery. MATERIALS AND METHODS: The clinical data were collected from hospital case records and pathological confirmation was done by a neuropathologist. Clinical details, imaging features, and treatment modalities were studied and were correlated with outcomes based on regular follow up...
April 17, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29677399/outcomes-of-cryptococcosis-in-renal-transplant-recipients-in-a-less-resourced-health-care-system
#5
Vinicius Ponzio, Luis F A Camargo, José O Medina-Pestana, John R Perfect, Arnaldo L Colombo
BACKGROUND: Cryptococcosis is the second most common cause of invasive fungal infections in renal transplant recipients in many countries, and data on graft outcome after treatment for this infection is lacking in less-resourced health care settings. METHODS: Data from 47 renal transplant recipients were retrospectively collected at a single institution during a period of 13 years. Graft dysfunction, graft loss and mortality rates were evaluated. Predictors of mortality and graft loss were estimated...
April 20, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29677130/lipid-biosynthesis-as-an-antifungal-target
#6
REVIEW
Jiao Pan, Cuiting Hu, Jae-Hyuk Yu
Lipids, commonly including phospholipids, sphingolipids, fatty acids, sterols, and triacylglycerols (TAGs), are important biomolecules for the viability of all cells. Phospholipids, sphingolipids, and sterols are important constituents of biological membranes. Many lipids play important roles in the regulation of cell metabolism by acting as signaling molecules. Neutral lipids, including TAGs and sterol esters (STEs), are important storage lipids in cells. In view of the importance of lipid molecules, this review briefly summarizes the metabolic pathways for sterols, phospholipids, sphingolipids, fatty acids, and neutral lipids in fungi and illustrates the differences between fungal and human (or other mammalian) cells, especially in relation to lipid biosynthetic pathways...
April 20, 2018: Journal of Fungi (Basel, Switzerland)
https://www.readbyqxmd.com/read/29677084/voriconazole-treatment-for-an-infant-with-intractable-candida-glabrata-meningitis
#7
Sophia Tsakiri, Chiamaka Aneji, Christine Domonoske, Lynnette Mazur, Daniel K Benjamin, Susan H Wootton
We report voriconazole levels in an infant with disseminated Candida glabrata infection who received combination antifungal therapy and rescue voriconazole treatment. Serum and CSF voriconazole levels were higher than anticipated and above target. Dose reduction did not lead to a reduction in the blood or CSF levels. The patient did not exhibit identifiable drug toxicity.
April 19, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29676953/overinduction-of-the-cyp51a-gene-after-exposure-to-azole-antifungals-provides-a-first-clue-to-the-resistance-mechanism-in-the-fusarium-solani-species-complex
#8
Maurine D'Agostino, Thomas Lemmet, Claire Dufay, Amandine Luc, Jean Pol Frippiat, Marie Machouart, Anne Debourgogne
The genus Fusarium is largely represented in fungal infections, not only mostly in plants but also in humans. Fungi belonging to the Fusarium solani species complex (FSSC) are those that are most frequently isolated in invasive fusariosis and present elevated minimum inhibitory concentrations for the main antifungal drugs used in medicine. This study is the first to investigate the resistance mechanism in FSSC by monitoring CYP51A expression in the presence of azole antifungals. After exposure to voriconazole, an overinduction of CYP51A was observed irrespective of the concentration of antifungal used and the generation studied...
April 20, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29676766/yeast-isolation-and-identification-in-water-used-in-a-brazilian-hemodialysis-unit-by-classic-microbiological-techniques-and-raman-spectroscopy
#9
Lilian Bueno Montanari, Flávio Garcia Sartori, Diórginis Bueno Montrazi Ribeiro, Luís Fernando Leandro, Regina Helena Pires, Márcia de Souza Carvalho Melhem, César Alexandre de Mello, Carlos Henrique Gomes Martins
The use of poorly treated water in hemodialysis centers may lead to fungal contamination, which poses a serious threat to immunologically debilitated hemodialysis patients. This study aimed to isolate and identify yeast species in the water of a Brazilian hemodialysis center by using classic microbiological techniques and Raman spectroscopy. For 12 months, a total of 288 water samples were collected from different points of the hemodialysis treatment distribution center. One hundred and forty-six yeast species were isolated and identified in the samples that tested positive for the presence of yeasts such as Candida parapsilosis (100 isolates, or 68...
April 2018: Journal of Water and Health
https://www.readbyqxmd.com/read/29676728/detection-of-candida-species-in-pregnant-chinese-women-with-a-molecular-beacon-method
#10
Yanhong Zhai, Jing Liu, Li Zhou, Tongzhen Ji, Lingxin Meng, Yang Gao, Ran Liu, Xiao Wang, Lin Li, Binghuai Lu, Zheng Cao
PURPOSE: Candida pathogens are commonly found in women and can cause vulvovaginal candidiasis (VVC), whose infection rate is further increased during pregnancy. We aimed to study the Candida prevalence and strain distribution in pregnant Chinese women with a molecular beacon assay. METHODOLOGY: From March 2016 to February 2017, a total of 993 pregnant women attending routine antenatal visits at the Beijing Obstetrics and Gynecology Hospital were enrolled. For Candida detection and identification, a unique molecular beacon assay was presented and compared with a traditional phenotypic method...
April 20, 2018: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29675765/proteomic-identification-and-purification-of-seed-proteins-from-native-amazonian-species-displaying-antifungal-activity
#11
Márcio V Ramos, Daniel Brito, Cléverson D T Freitas, José Francisco C Gonçalves, Camila T M N Porfirio, Marina D P Lobo, Ana Cristina O Monteiro-Moreira, Luiz A C Souza, Andreia V Fernandes
Seeds of native species from the rain forest (Amazon) are source of chitinases and their protein extracts exhibited strong and broad antifungal activity. Numerous plant species native to the Amazon have not yet been chemically studied. Studies of seeds are scarcer, since adversities in accessing study areas and seasonality pose constant hurdles to systematic research. In this study, proteins were extracted from seeds belonging to endemic Amazon species and were investigated for the first time. Proteolytic activity, peptidase inhibitors, and chitinases were identified, but chitinolytic activity predominated...
April 19, 2018: Planta
https://www.readbyqxmd.com/read/29675561/de-escalation-of-antifungal-treatment-in-critically-ill-patients-with-suspected-invasive-candida-infection-incidence-associated-factors-and-safety
#12
Karim Jaffal, Julien Poissy, Anahita Rouze, Sébastien Preau, Boualem Sendid, Marjorie Cornu, Saad Nseir
BACKGROUND: Antifungal treatment is common in critically ill patients, but only a small proportion of patients receiving antifungals have a proven fungal infection. However, antifungal treatment has side effects such as toxicity, emergence of resistance, and high cost. Moreover, empirical antifungal treatment is still a matter for debate in these patients. Our study aimed to determine the incidence, associated factors, and safety of de-escalation of antifungals in critically ill patients...
April 19, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29675414/spondyloarthritis-acute-anterior-uveitis-and-fungi-updating-the-catterall-king-hypothesis
#13
Martin Laurence, Mark Asquith, James T Rosenbaum
Spondyloarthritis is a common type of arthritis which affects mostly adults. It consists of idiopathic chronic inflammation of the spine, joints, eyes, skin, gut, and prostate. Inflammation is often asymptomatic, especially in the gut and prostate. The HLA-B*27 allele group, which presents intracellular peptides to CD8+ T cells, is by far the strongest risk factor for spondyloarthritis. The precise mechanisms and antigens remain unknown. In 1959, Catterall and King advanced a novel hypothesis explaining the etiology of spondyloarthritis: an as-yet-unrecognized sexually acquired microbe would be causing all spondyloarthritis types, including acute anterior uveitis...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29675005/effects-of-acetone-fraction-from-buchenavia-tomentosa-aqueous-extract-and-gallic-acid-on-candida-albicans-biofilms-and-virulence-factors
#14
Guilherme R Teodoro, Aline V L Gontijo, Marcos J Salvador, Márcia H Tanaka, Fernanda L Brighenti, Alberto C B Delbem, Ádina C B Delbem, Cristiane Y Koga-Ito
A promising anti- Candida activity of Buchenavia tomentosa extracts was recently described. In the present work, experiments were carried out to determine the fraction with higher antifungal activity from a B. tomentosa extract. Acetone fraction (AF) was obtained from the aqueous extract from dried leaves (5 min/100°C) and it was the most effective one. Gallic acid (GA) was identified by electrospray ionization mass spectrometry (ESI-MS) and also chosen to perform antifungal tests due to its promising activity on Candida albicans ...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29674635/design-synthesis-biological-activity-and-structure-activity-relationship-studies-of-chalcone-derivatives-as-potential-anti-candida-agents
#15
Jéssica T Andrade, Felipe R S Santos, William G Lima, Carla D F Sousa, Lohanna S F M Oliveira, Rosy I M A Ribeiro, Ana J P S Gomes, Marcelo G F Araújo, José A F P Villar, Jaqueline M S Ferreira
Vulvovaginal candidiasis (VVC) affects millions of women around the world every year. Candida albicans is the most frequently isolated pathogen in women and its rapid ability to develop resistance to first and second line therapies has boosted the search for new and effective antifungal agents. In this study, we show the in vitro anti-Candida activity of fifteen synthetic chalcone analogs and their antifungal potential in an in vivo model of VVC. Chalcone 12 showed potent antifungal effects, being able to inhibit the growth of Candida spp...
April 19, 2018: Journal of Antibiotics
https://www.readbyqxmd.com/read/29673771/posaconazole-vs-voriconazole-in-the-prevention-of-invasive-fungal-diseases-in-patients-with-haematological-malignancies-a-retrospective-study
#16
L Tang, X-F Yang, M Qiao, L Zhang, X-W Tang, H-Y Qiu, D-P Wu, A-N Sun
BACKGROUND: Posaconazole is superior to fluconazole or itraconazole in preventing invasive fungal diseases (IFDs) in patients with haematological malignancies; however, there have been reports of the comparing posaconazole and voriconazole. METHODS: This single-centre, retrospective study in China enrolled AML, ALL and MDS patients, among others. Prophylaxis with posaconazole or voriconazole was administered for patients recovering from neutropenia or who had achieved complete remission...
April 16, 2018: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29673770/the-in-vitro-efficacy-of-sunsmile-%C3%A2-fruit-vegetable-rinse-against-pathogenic-strains-of-prototheca-algae-that-cause-mastitis-in-cows
#17
B Grzesiak, H Krukowski, A Głowacka
The research concerns algae of the genus Prototheca. They are found in the natural environment and they can cause a disease in animals and humans called protothecosis. The aim of the study was to evaluate the in vitro activity of the fruit and vegetable rinse agent SunSmile® Fruit & Vegetable Rinse (Sunrider International) against P. zopfii isolates. The materials consisted of ten P. zopfii strains isolated from the milk of cows with mastitis. The following antifungal chemotherapeutic agents were also used in the study for comparison: nystatin, ketoconazole, amphothericin B, miconazole, clotrimazole, econazole, fluconazole, and flucytosine...
April 16, 2018: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29673769/successful-treatment-of-a-recurrent-aspergillus-niger-otomycosis-with-local-application-of-voriconazole
#18
M Chappe, S Vrignaud, L de Gentile, G Legrand, F Lagarce, Y Le Govic
Fungal otitis (otomycosis) is a common infection encountered by otolaryngologists. Nevertheless, its management can be challenging because of its high recurrence rate and of the limited therapeutic options. A 45-year-old woman suffered from recurrent otomycosis. The ineffectiveness of successive antibiotic cures and repeated topical treatments with nystatin and then with econazole cream led to perform microbiological analyses. Culture of ear swab grew Aspergillus niger. The use of a 1% voriconazole sterile solution previously validated for treatment of eye infections was considered after ensuring the absence of known ototoxic effects of the antifungal and of the excipients...
April 16, 2018: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29673562/candida-tropicalis-burn-wound-sepsis-a-series-of-histopathology-confirmed-cases
#19
Chunjie Fan, Qingfen Tian, Guobao Huang, Lei Zhang, Qiuhe Wu, Keyan Zhang
Fungal infection in severely burned patients is a serious problem due to various factors, such as the extensive application of antibiotics. In this study, we report on the course of severely burned patients with Candida tropicalis burn wound sepsis. Five such cases were reviewed. The patients were treated with itraconazole intravenously and simultaneous antibiotics to prevent bacterial infections. In addition, dermabrasion was used to excise the eschar and the wound surface was covered immediately with dermatoplasty...
April 16, 2018: Intensive & Critical Care Nursing: the Official Journal of the British Association of Critical Care Nurses
https://www.readbyqxmd.com/read/29672274/cutaneous-mucormycosis-as-a-presenting-feature-of-type-1-diabetes-in-a-boy-case-report-and-review-of-the-literature
#20
Ganesh Jevalikar, Siddhnath Sudhanshu, Sanjay Mahendru, Smita Sarma, Khalid J Farooqui, Ambrish Mithal
BACKGROUND: Mucormycosis is a potentially fatal complication of diabetes. The rhino-orbito-cerebral form is the most common presentation, however, rarely other types can also be seen. CASE PRESENTATION: We describe the case of a 4½ -year-old boy not previously known to be a diabetic who presented to the plastic surgery department for gangrene of the left middle finger with surrounding erythema and induration. After the diagnosis of diabetes and initial treatment, pus from the wound showed broad aseptate hyphae suggestive of mucormycosis which was further confirmed on culture...
April 19, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
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