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https://www.readbyqxmd.com/read/28194484/perturbations-of-the-anti-ageing-hormone-klotho-in-patients-with-type-1-diabetes-and-microalbuminuria
#1
Giuseppe Maltese, Nikolaos Fountoulakis, Richard C Siow, Luigi Gnudi, Janaka Karalliedde
AIMS/HYPOTHESIS: Patients with type 1 diabetes and microalbuminuria are at high risk of cardiovascular disease (CVD) and end-stage renal disease. Soluble Klotho is an anti-ageing circulating hormone involved in phosphate metabolism and vascular homeostasis through protective effects on the endothelium and antioxidant actions. The role of soluble Klotho in patients with type 1 diabetes and microalbuminuria is unknown. METHODS: In a cross-sectional single-centre study we evaluated the levels of circulating serum soluble Klotho in 33 participants with type 1 diabetes and a history of microalbuminuria (receiving renin-angiotensin system [RAS] inhibitors) and 45 participants with type 1 diabetes without a history of microalbuminuria (not receiving RAS or other antihypertensive drugs)...
February 13, 2017: Diabetologia
https://www.readbyqxmd.com/read/28178934/the-prevalence-and-incidence-of-frailty-in-pre-diabetic-and-diabetic-community-dwelling-older-population-results-from-beijing-longitudinal-study-of-aging-ii-blsa-ii
#2
Jagadish Kumar Chhetri, Zheng Zheng, Xitong Xu, Cuihong Ma, Piu Chan
BACKGROUND: Various factors including cardio-metabolic disorders are found to be correlated with frailty. With the increase in age, older adults are likely to have elevated blood glucose level. In this study we intend to investigate the prevalence and incidence of frailty in the pre-diabetic and diabetic community dwelling elderly population and the associated risk factors. METHODS: At baseline total of 10,039 subjects with a mean age of 70.51 (±7.82) were included...
February 8, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28178390/metabolic-and-hemodynamic-effects-of-sodium-dependent-glucose-co-transporter-2-inhibitors-on-cardio-renal-protection-in-the-treatment-of-patients-with-type-2-diabetes-mellitus
#3
REVIEW
Atsunori Kashiwagi, Hiroshi Maegawa
The specific Na+/glucose co-transporter 2 inhibitors (SGLT2 inhibitors) inhibit glucose reabsorption in proximal renal tubular cells, and both fasting and postprandial glucose significantly decrease due to urinary glucose loss. As a result, pancreatic β-cell function and peripheral insulin action significantly improve with relief from glucose toxicity. Furthermore, whole body energy metabolism changes to relative glucose deficiency and triggers increased lipolysis in fat cells, and fatty acid oxidation and then ketone body production in the liver during treatment with SGLT2 inhibitors...
February 8, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28177677/mtorc1-inhibitors-rapamycin-and-metformin-affect-cardiovascular-markers-differentially-in-zdf-rats
#4
Ravi Nistala, Ahmad Raja, Lakshmi Pulakat
Mammalian target for rapamycin complex 1 (mTORC1) is a common target for the action of immunosuppressant macrolide rapamycin and glucose lowering metformin. Inhibition of mTORC1 can exert both beneficial and detrimental effects in different pathologies. Here we investigated the differential effects of rapamycin (1.2mg/kg/day delivered subcutaneously for six weeks) and metformin (300mg/kg/day delivered orally for 11 weeks) treatments on male Zucker diabetic fatty (ZDF) rats that mimic the cardio-renal pathology of T2DM patients and progress to insulin insufficiency...
January 4, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28169059/the-diagnostic-sensitivity-of-circulating-cardio-enriched-micrornas-is-increased-after-normalization-of-high-density-lipoprotein-levels
#5
Thrishila Parshu Ram, Ingrid Fomison-Nurse, Sophie Gandhi, Sean Coffey, Pankaj Saxena, Ivor Galvin, Richard Bunton, Michael J A Williams, Regis R Lamberts, Rajesh Katare
BACKGROUND: Emerging evidence suggests that microRNAs (miRs) could be a potential biomarker to identify early molecular alterations in the heart. HDL are the major carriers for miRs into the circulation. This study tested whether changes in the level of HDL could affect the diagnostic sensitivity of miRs. METHODS AND RESULTS: Peripheral blood samples were collected from 20 diabetic and 22 age and gender matched non-diabetic patients undergoing coronary artery bypass graft (CABG) surgery for ischemic heart disease (IHD)...
January 26, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28164755/regulation-of-na-k-atpase-by-estradiol-and-igf-1-in-cardio-metabolic-diseases
#6
Milan Obradovic, Julijana Stanimirovic, Anastasija Panic, Nikola Bogdanovic, Emina Sudar-Milovanovic, Desanka Cenic-Milosevic, Esma R Isenovic
BACKGROUND: The sodium/potassium- adenosine- triphosphatase (Na+/K+-ATPase) is an important mediator in vasculature tone and contractility, and its abnormal regulation has been implicated in many diseases such as obesity, insulin resistance, diabetes, and hypertension. Decreased Na+/K+-ATPase abundance and its altered isoform expression induce cardiomyocytes death and cardiac dysfunction, possibly leading to the development of myocardial dilation and heart failure. Therefore, the regulation of Na+/K+-ATPase activity/expression could be important in treatment and possible prevention of cardio-metabolic diseases...
February 3, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28164545/plasma-zonulin-and-its-association-with-kidney-function-severity-of-heart-failure-and-metabolic-inflammation
#7
Thomas B Dschietzig, Felix Boschann, Jana Ruppert, Franz P Armbruster, Andreas Meinitzer, Dragic Bankovic, Veselin Mitrovic, Christoph Melzer
BACKGROUND: The tight junction regulator zonulin has attracted clinical attention as a biomarker of increased gastrointestinal permeability. Recent work also suggests zonulin to represent a general regulator of tissue barriers and a player in metabolic inflammation. Here, we investigated the associations of zonulin with chronic heart failure (CHF), kidney function, and metabolic inflammation. METHODS: Using multiple linear regression (Generalized Linear Model), this study determined the association of plasma zonulin with different laboratory and clinical parameters in 225 patients carrying automatic implantable cardioverters/defibrillators (AICD) for primary or secondary prevention...
December 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28162956/exercise-and-ectopic-fat-in-type-2-diabetes-a-systematic-review-and-meta-analysis
#8
REVIEW
A Sabag, K L Way, S E Keating, R N Sultana, H T O'Connor, M K Baker, V H Chuter, J George, N A Johnson
Ectopic adipose tissue surrounding the intra-abdominal organs (visceral fat) and located in the liver, heart, pancreas and muscle, is linked to cardio-metabolic complications commonly experienced in type 2 diabetes. A systematic review and meta-analysis was performed to determine the effect of exercise on ectopic fat in adults with type 2 diabetes. Relevant databases were searched to February 2016. Included were randomised controlled studies, which implemented≥4 weeks of aerobic and/or resistance exercise and quantified ectopic fat via magnetic resonance imaging, computed tomography, proton magnetic resonance spectroscopy or muscle biopsy before and after intervention...
February 2, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28161619/combination-of-metformin-with-chemotherapeutic-drugs-via-different-molecular-mechanisms
#9
REVIEW
Mei Peng, Kwame Oteng Darko, Ting Tao, Yanjun Huang, Qiongli Su, Caimei He, Tao Yin, Zhaoqian Liu, Xiaoping Yang
Metformin, a widely prescribed drug for treating type II diabetes, is one of the most extensively recognized metabolic modulators which has shown an important anti-cancer property. However, fairly amount of clinical trials on its single administration have not demonstrated a convincing efficiency yet. Thus, recent studies tend to combine metformin with clinical commonly used chemotherapeutic drugs to decrease their toxicity and attenuate their tumor resistance. These strategies have displayed promising clinical benefits...
January 23, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28151941/does-training-and-support-of-general-practitioners-in-intensive-treatment-of-people-with-screen-detected-diabetes-improve-medication-morbidity-and-mortality-in-people-with-clinically-diagnosed-diabetes-investigation-of-a-spill-over-effect-in-a-cluster-rct
#10
Morten Charles, Mette V Skriver, Simon J Griffin, Rebecca K Simmons, Daniel R Witte, Else-Marie Dalsgaard, Torsten Lauritzen, Annelli Sandbæk
INTRODUCTION: Very few studies have examined the potential spill-over effect of a trial intervention in general practice. We investigated whether training and support of general practitioners in the intensive treatment of people with screen-detected diabetes improved rates of redeemed medication, morbidity and mortality in people with clinically-diagnosed diabetes. METHODS: This is a secondary, post-hoc, register-based analysis linked to a cluster randomised trial...
2017: PloS One
https://www.readbyqxmd.com/read/28124685/blood-pressure-and-cardiovascular-morbidity-risk-in-type-2-diabetes-with-hypertension-over-a-decade-of-follow-up-evidence-for-j-shaped-phenomenon
#11
S Riyahi-Alam, A Derakhshan, M A Mansournia, N Mansournia, M Almasi, F Azizi, F Hadaegh
There is still debate on whether the relationship between blood pressure (BP) and risk of cardiovascular diseases (CVD) in patients with type 2 diabetes (T2D) is linear or not. Since these cardio-metabolic disturbances share interrelated complex pathogenic mechanisms, we aimed to assess the relationship of baseline systolic (SBP)/diastolic pressures with CVD and coronary heart disease (CHD) events in a cohort of Iranians with T2D during a median follow-up of 8.8 years. Of all 1009 eligible participants with T2D with a mean (s...
January 26, 2017: Journal of Human Hypertension
https://www.readbyqxmd.com/read/28120715/hormonal-regulation-of-nitric-oxide-no-in-cardio-metabolic-diseases
#12
Emina Sudar-Milovanovic, Sonja Zafirovic, Aleksandra Jovanovic, Jovana Trebaljevac, Milan Obradovic, Desanka Cenic-Milosevic, Esma R Isenovic
BACKGROUND: Nitric oxide (NO) is a potential biochemical, cardio-metabolic risk marker. The production of NO is catalyzed by different isoforms of enzymes, NO synthases (NOS). An altered NO level is associated with obesity, insulin resistance (IR), diabetes and cardiovascular diseases (CVD). Activity of NOS and NO production are regulated by various hormones under physiological and pathophysiological condition. METHODS: Data used for this review were obtained by searching the electronic database [PUBMED/MEDLINE 1984 - May 2016]...
January 24, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28107484/resveratrol-co-treatment-attenuates-the-effects-of-hiv-protease-inhibitors-on-rat-body-weight-and-enhances-cardiac-mitochondrial-respiration
#13
Burger Symington, Rudo F Mapanga, Gavin R Norton, M Faadiel Essop
Since the early 1990s human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) emerged as a global health pandemic, with sub-Saharan Africa the hardest hit. While the successful roll-out of antiretroviral (ARV) therapy provided significant relief to HIV-positive individuals, such treatment can also elicit damaging side-effects. Here especially HIV protease inhibitors (PIs) are implicated in the onset of cardio-metabolic complications such as type-2 diabetes and coronary heart disease. As there is a paucity of data regarding suitable co-treatments within this context, this preclinical study investigated whether resveratrol (RSV), aspirin (ASP) or vitamin C (VitC) co-treatment is able to blunt side-effects in a rat model of chronic PI exposure (Lopinavir/Ritonavir treatment for 4 months)...
2017: PloS One
https://www.readbyqxmd.com/read/28100847/genetic-background-of-aberrant-thermogenin-expression-ucp1-in-obesity-leading-to-metabolic-syndrome
#14
Małgorzata Stosio, Agata Witkowicz, Anna Kowalska, Lidia Karabon
Cardiovascular and metabolic disturbances individually and interdependently lead to chronic pathological conditions observed in cardio-metabolic diseases (CMDs). In Europe, the morbidity and mortality caused by cardiovascular disease are the highest among all diseases. Therefore, it seems important to search for new and alternative therapies for obesity, which is the main cause of type 2 diabetes (T2D) and cardiovascular disease (CD). Great attention has been paid to the role of brown adipose tissue in fat burning and the possibility of transformation of the white adipose tissue to cells with brown adipose tissue function as a potential form of treatment of obesity...
December 31, 2016: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/28096205/effect-of-prepublication-results-on-trends-in-prescribing-of-antihypertensive-medication-impact-of-the-altitude-aliskiren-trial-in-type-2-diabetes-using-cardio-renal-disease-endpoints-trial-on-aliskiren-prescribing
#15
Sahar S Othman, Peter C Austin, Jack V Tu, Douglas S Lee
No abstract text is available yet for this article.
January 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/28051185/serum-uric-acid-levels-are-associated-with-obesity-but-not-cardio-cerebrovascular-events-in-chinese-inpatients-with-type-2-diabetes
#16
Ming-Yun Chen, Cui-Chun Zhao, Ting-Ting Li, Yue Zhu, Tian-Pei Yu, Yu-Qian Bao, Lian-Xi Li, Wei-Ping Jia
We aim to explore the associations between serum uric acid (SUA) and obesity and cardio-cerebrovascular events (CCEs) in Chinese inpatients with type 2 diabetes mellitus (T2DM). 2 962 inpatients with T2DM were stratified into quartile based on SUA concentrations. There were significant increases in the prevalence of both obesity (32.6%, 41.9%, 50.1%, and 62.8%, respectively, p < 0.001 for trend) and severe obesity (0.4%, 0.6%, 0.8%, and 1.3%, respectively, p < 0.001 for trend) across the SUA quartiles...
January 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28043815/associations-among-insulin-resistance-triacylglycerol-high-density-lipoprotein-tag-hdl-ratio-and-thyroid-hormone-levels-a-study-on-type-2-diabetes-mellitus-in-obese-and-overweight-subjects
#17
Rajendran Jayanthi, Abu Raghavan Srinivasan, Mohammed Hanifah, Anandraj Lokesh Maran
AIM: Triacylglycerol/High density lipoprotein (TAG/HDL) ratio, a surrogate marker of LDL particle size (small dense) was included in our study to observe the link with insulin resistance and thyroid co-morbidity. METHODS: Ninety three patients with T2DM of both genders were enrolled from a tertiary health care unit in Puducherry, during the latter half of 2015. The cardio-metabolic risk factors were assessed through body mass index (BMI), blood pressure, fasting blood glucose and lipid profile, glycated haemoglobin and homeostasis model assessment of insulin resistance (HOMA-IR)...
December 23, 2016: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28043708/emerging-roles-of-sodium-glucose-cotransporter-2-inhibitors-in-cardiology
#18
REVIEW
Atsushi Tanaka, Koichi Node
The ultimate goal of treatment in people with diabetes mellitus is to prevent development of cardiovascular (CV) disease, resulting in prolongation of healthy life expectancy. Although impaired glycemic metabolism has a central role in its pathology, a number of studies have demonstrated that remedy for its imbalance cannot necessarily be accomplished as a therapeutic goal. A comprehensive medical approach against multi-factorial pathologies in diabetes, such as insulin resistance, obesity, hypertension, and dyslipidemia, in addition to diet and exercise therapy should be rather performed in the routine clinical setting...
March 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28040864/glp-1-receptor-independent-pathways-emerging-beneficial-effects-of-glp-1-breakdown-products
#19
REVIEW
Valeria Guglielmi, Paolo Sbraccia
The glucagon-like peptide-1 (GLP-1) axis has emerged as a major therapeutic target for the treatment of type 2 diabetes and, recently, of obesity. The insulinotropic activity of the native incretin hormone GLP-1(7-36)amide, which is mainly exerted through a unique G protein-coupled receptor (GLP-1R), is terminated via enzymatic cleavage by dipeptidyl peptidase-IV that generates a C-terminal GLP-1 metabolite GLP-1(9-36)amide, the major circulating form in plasma. GLP-1(28-36)amide and GLP-1(32-36)amide are further cleavage products derived from GLP-1(7-36)amide and GLP-1(9-36)amide by the action of a neutral endopeptidase known as neprilysin...
December 31, 2016: Eating and Weight Disorders: EWD
https://www.readbyqxmd.com/read/28032340/the-burden-of-common-skin-diseases-assessed-with-the-eq5d-a-european-multi-centre-study-in-13-countries
#20
F Balieva, J Kupfer, L Lien, U Gieler, A Y Finlay, L Tomas-Aragonés, F Poot, L Misery, F Sampogna, H van Middendorp, J A Halvorsen, J C Szepietowski, A Lvov, S E Marrón, M S Salek, F J Dalgard
BACKGROUND: Generic instruments measuring health related quality of life (HRQoL), like EQ5D, enable comparison of skin diseases with healthy populations and non-dermatological medical conditions, as well as calculation of utility data. OBJECTIVES: The aims were to measure HRQoL in patients with common skin diseases and healthy controls across Europe using the EQ5D. METHODS: This multi-center observational cross-sectional study was conducted in 13 European countries...
December 29, 2016: British Journal of Dermatology
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