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https://www.readbyqxmd.com/read/29040868/identification-of-a-novel-proinsulin-associated-snp-and-demonstration-that-proinsulin-is-unlikely-to-be-a-causal-factor-in-subclinical-vascular-remodelling-using-mendelian-randomisation
#1
Rona J Strawbridge, Angela Silveira, Marcel den Hoed, Stefan Gustafsson, Jian'an Luan, Denis Rybin, Josée Dupuis, Ruifang Li-Gao, Maryam Kavousi, Abbas Dehghan, Kadri Haljas, Jari Lahti, Jesper R Gådin, Alexandra Bäcklund, Ulf de Faire, Karl Gertow, Phillipe Giral, Anuj Goel, Steve E Humphries, Sudhir Kurl, Claudia Langenberg, Lars L Lannfelt, Lars Lind, Cecilia C M Lindgren, Elmo Mannarino, Dennis O Mook-Kanamori, Andrew P Morris, Renée de Mutsert, Rainer Rauramaa, Peter Saliba-Gustafsson, Bengt Sennblad, Andries J Smit, Ann-Christine Syvänen, Elena Tremoli, Fabrizio Veglia, Björn Zethelius, Hanna M Björck, Johan G Eriksson, Albert Hofman, Oscar H Franco, Hugh Watkins, J Wouter Jukema, Jose C Florez, Nicholas J Wareham, James B Meigs, Erik Ingelsson, Damiano Baldassarre, Anders Hamsten
BACKGROUND AND AIMS: Increased proinsulin relative to insulin levels have been associated with subclinical atherosclerosis (measured by carotid intima-media thickness (cIMT)) and are predictive of future cardiovascular disease (CVD), independently of established risk factors. The mechanisms linking proinsulin to atherosclerosis and CVD are unclear. A genome-wide meta-analysis has identified nine loci associated with circulating proinsulin levels. Using proinsulin-associated SNPs, we set out to use a Mendelian randomisation approach to test the hypothesis that proinsulin plays a causal role in subclinical vascular remodelling...
September 28, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29037887/depression-and-related-risk-factors-among-patients-with-type-2-diabetes-mellitus-jazan-area-ksa-a-cross-sectional-study
#2
Osama B Albasheer, Mohammed S Mahfouz, Yahia Solan, Duaa A Khan, Mohammed A Muqri, Haneen A Almutairi, Ali M Alelyani, Hussain A Alahmed
PURPOSE: To determine the prevalence of depression and related risk factors among type 2 diabetes mellitus patients (T2DM) in Jazan area, Saudi Arabia. METHOD: A cross sectional, self-administered questionnaire study was conducted among T2DM patients in Jazan area, Saudi Arabia. A total of 385 patients were selected at randomly. The Patient Health Questionnaire (PHQ-9) was utilized to measure symptoms and signs of depression. RESULTS: The overall prevalence of depression among T2DM patients was 37...
September 28, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29029108/relative-risks-of-contributing-factors-to-morbidity-and-mortality-in-adults-with-craniopharyngioma-on-gh-replacement
#3
Kevin C J Yuen, Anders F Mattsson, Pia Burman, Eva-Marie Erfurth, Cecilia Camacho-Hubner, Janet L Fox, Johan Verhelst, Mitchell E Geffner, Roger Abs
Context: Craniopharyngioma (CP) in adults, of either childhood-onset (CO-CP) or adult-onset (AO-CP), is associated with increased morbidity and mortality, but data on the relative risks (RRs) of contributing factors are lacking. Objective: To assess the RRs of factors contributing to morbidity and mortality of adults with CO-CP and AO-CP. Methods: Data on 1,669 CP patients from KIMS (Pfizer International Metabolic Database) were analyzed using univariate and multiple Poisson and Cox regression methods...
September 29, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29019365/blueberry-supplementation-attenuates-oxidative-stress-within-monocytes-and-modulates-immune-cell-levels-in-adults-with-metabolic-syndrome-a-randomized-double-blind-placebo-controlled-trial
#4
Anand R Nair, Nithya Mariappan, April J Stull, Joseph Francis
BACKGROUND: Blueberries (BB) have been shown to improve insulin sensitivity and endothelial function in obese and pre-diabetic humans, and decrease oxidative stress and inflammation, and ameliorate cardio-renal damage in rodents. This indicates that blueberries have a systemic effect and are not limited to a particular organ system. In order for blueberries to exert beneficial effects on the whole body, the mechanism would logically have to operate through modulation of cellular humoral factors...
October 11, 2017: Food & Function
https://www.readbyqxmd.com/read/28993156/association-between-hemoglobin-glycation-index-and-hepatic-steatosis-in-non-diabetic-individuals
#5
Teresa Vanessa Fiorentino, Maria Adelaide Marini, Elena Succurro, Francesco Andreozzi, Angela Sciacqua, Marta Letizia Hribal, Francesco Perticone, Giorgio Sesti
AIMS: Hemoglobin glycation index (HGI), which is the difference between the observed value of HbA1 and the predicted HbA1c based on plasma glucose levels, represents a measure of the degree of non-enzymatic glycation of hemoglobin and it has been found to be positively associated with diabetic complications. Herein we investigated whether HGI is associated with hepatic steatosis and related biomarkers in subjects without diabetes. METHODS: 1120 White individuals without diabetes were stratified in quartiles according to HGI levels...
October 6, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28984071/type-2-diabetes-does-pancreatic-fat-really-matter
#6
REVIEW
V Guglielmi, P Sbraccia
With obesity increasing prevalence, the interest of research in non alcoholic fatty pancreas disease (NAFPD) is grown. Even though the pancreas appears more susceptible to lipid accumulation compared to the liver, NAFPD has been less investigated due to the limits in detecting techniques. Several definitions and synonyms for NAFPD are used by authors and can be misleading. This, together with differences in methodology and ethnicity population, makes the integration and comparison of studies on this topic challenging...
October 5, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28980284/adiponectin-correlates-with-body-mass-index-and-to-a-lesser-extent-with-left-ventricular-mass-in-dialysis-patients
#7
Afrim Poniku, Gani Bajraktari, Shpend Elezi, Pranvera Ibrahimi, Michael Y Henein
BACKGROUND: Adiponectin is a serum protein produced by adipose tissue which exerts anti-inflammatory, anti-diabetic and anti-atherosclerotic properties, hence is considered a cardio-protective marker. With the current uncertain role of adiponectin in dialysis patients to the aim of this study was to investigate its relationship with left ventricular (LV) structure and function in these patients. METHODS: This study included 89 (age 56 ± 13 years, 43% male) patients treated with regular dialysis for > 6 months, and 55 control subjects with normal renal function...
October 5, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28963288/adiposity-measures-and-arterial-stiffness-in-primary-care-the-mark-prospective-observational-study
#8
Leticia Gomez-Sanchez, Luis Garcia-Ortiz, Maria C Patino-Alonso, Jose I Recio-Rodriguez, Fernando Rigo, Ruth Martí, Cristina Agudo-Conde, Emiliano Rodriguez-Sanchez, Jose A Maderuelo-Fernandez, Rafel Ramos, Manuel A Gomez-Marcos
BACKGROUND: The cardiovascular risk of obesity is potentially increased by arterial stiffness. OBJECTIVE: To assess the relationship of adiposity measures with arterial stiffness in Caucasian adults with intermediate cardiovascular risk. SETTING: Six Spanish health centres. PARTICIPANTS: We enrolled 2354 adults (age range, 35-74 years; mean age, 61.4±7.7 years, 61.9% male). METHODS: This is a cross-sectional study that analyses data from the baseline visit of the improving interMediAte RisK management (MARK) study...
September 27, 2017: BMJ Open
https://www.readbyqxmd.com/read/28956668/biomarkers-of-diabetic-nephropathy-a-2017-update
#9
Nektaria Papadopoulou-Marketou, Christina Kanaka-Gantenbein, Nikolaos Marketos, George P Chrousos, Ioannis Papassotiriou
Diabetic nephropathy (DN), also named diabetic kidney disease (DKD), is a devastating complication in patients with both type 1 and 2 diabetes mellitus (T1D and T2D) and its diagnosis has been traditionally based on the presence of micro-albuminuria (MA). The aim of this article is to update, through review of the relevant medical literature, the most promising biomarkers for early DKD detection. MA has historically been employed as an early marker of microvascular complications, indicating risk for advanced CKD...
August 2017: Critical Reviews in Clinical Laboratory Sciences
https://www.readbyqxmd.com/read/28950867/biosynthesis-and-engineering-of-kaempferol-in-saccharomyces-cerevisiae
#10
Lijin Duan, Wentao Ding, Xiaonan Liu, Xiaozhi Cheng, Jing Cai, Erbing Hua, Huifeng Jiang
BACKGROUND: Kaempferol is a flavonol with broad bioactivity of anti-oxidant, anti-cancer, anti-diabetic, anti-microbial, cardio-protective and anti-asthma. Microbial synthesis of kaempferol is a promising strategy because of the low content in primary plant source. METHODS: In this study, the biosynthesis pathway of kaempferol was constructed in the budding yeast Saccharomyces cerevisiae to produce kaempferol de novo, and several biological measures were taken for high production...
September 26, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/28950710/microrna-and-diabetic-complications-a-clinical-perspective
#11
Baoqi Fan, Andrea On Yan Luk, Juliana C N Chan, Ronald Ching Wan Ma
SIGNIFICANCE: The rising global prevalence of diabetes and its debilitating complications give rise to significant disability and premature mortality. Due to the silent nature of diabetes and its vascular complications, and limitations in current methods for detection, there is a need for novel biomarkers for early detection and prognosis. Recent Advances: Metabolic memory and epigenetic factors are important in the pathogenesis of diabetic complications and interact with genetic variants, metabolic factors and clinical risk factors...
September 26, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28943861/a-practical-and-time-efficient-high-intensity-interval-training-program-modifies-cardio-metabolic-risk-factors-in-adults-with-risk-factors-for-type-ii-diabetes
#12
Bethan E Phillips, Benjamin M Kelly, Mats Lilja, Jesús Gustavo Ponce-González, Robert J Brogan, David L Morris, Thomas Gustafsson, William E Kraus, Philip J Atherton, Niels B J Vollaard, Olav Rooyackers, James A Timmons
INTRODUCTION: Regular physical activity (PA) can reduce the risk of developing type 2 diabetes, but adherence to time-orientated (150 min week(-1) or more) PA guidelines is very poor. A practical and time-efficient PA regime that was equally efficacious at controlling risk factors for cardio-metabolic disease is one solution to this problem. Herein, we evaluate a new time-efficient and genuinely practical high-intensity interval training (HIT) protocol in men and women with pre-existing risk factors for type 2 diabetes...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28939642/dietary-fat-modulation-of-hepatic-lipase-variant-514-c-t-for-lipids-a-crossover-randomized-dietary-intervention-in-caribbean-hispanics
#13
Caren E Smith, Maria I Van Rompay, Josiemer Mattei, Juan F Garcia, Bibiana Garcia-Bailo, Alice H Lichtenstein, Katherine L Tucker, Jose M Ordovas
Background and Aims-The hepatic lipase (LIPC) locus is a well-established determinant of high-density lipoprotein cholesterol (HDL-C) concentrations, an association that is modified by dietary fat in observational studies. Dietary interventions are lacking. METHODS AND RESULTS: We investigated dietary modulation of LIPC rs1800588 (-514 C/T) for lipids and glucose using a randomized cross-over design comparing a high-fat Western diet and a low-fat traditional Hispanic diet in individuals of Caribbean Hispanics descent (n=42; 4 weeks/phase)...
September 22, 2017: Physiological Genomics
https://www.readbyqxmd.com/read/28931350/sex-differences-in-associations-of-cardio-ankle-vascular-index-with-left-ventricular-function-and-geometry
#14
Zi Ye, Patricia A Pellikka, Iftikhar J Kullo
The cardio-ankle vascular index (CAVI) is a measure of global arterial stiffness. We hypothesized that CAVI is associated with left ventricular (LV) function and geometry in individuals without structural heart disease. We measured CAVI in 600 participants (mean age 60.3±14.6 years, 54% men) without history of atherosclerotic cardiovascular disease who were referred for transthoracic echocardiography. Linear regression analysis was used to assess the association of CAVI with LV function (peak mitral annular systolic s' and early diastolic velocity e') and structure (LV mass index (LVMI) and relative wall thickness (RWT))...
September 1, 2017: Vascular Medicine
https://www.readbyqxmd.com/read/28929340/sleep-and-cardio-metabolic-disease
#15
REVIEW
Francesco P Cappuccio, Michelle A Miller
PURPOSE OF REVIEW: This review summarises and discusses the epidemiological evidence suggesting a causal relationship between sleep duration and cardio-metabolic risk and outcomes in population. RECENT FINDINGS: Sleep duration is affected by a variety of cultural, social, psychological, behavioural, pathophysiological and environmental influences. Changes in modern society-like longer working hours, more shift-work, 24/7 availability of commodities and 24-h global connectivity-have been associated with a gradual reduction in sleep duration and sleeping patterns across westernised populations...
September 19, 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/28924247/low-level-activity-thresholds-for-changes-in-nmr-biomarkers-and-genes-in-high-risk-subjects-for-type-2-diabetes
#16
Karl-Heinz Herzig, Juhani Leppäluoto, Jari Jokelainen, Emmanuelle Meugnier, Sandra Pesenti, Harri Selänne, Kari A Mäkelä, Riikka Ahola, Timo Jämsä, Hubert Vidal, Sirkka Keinänen-Kiukaanniemi
Our objectives were to determine if there are quantitative associations between amounts and intensities of physical activities (PA) on NMR biomarkers and changes in skeletal muscle gene expressions in subjects with high risk for type 2 diabetes (T2D) performing a 3-month PA intervention. We found that PA was associated with beneficial biomarker changes in a factor containing several VLDL and HDL subclasses and lipids in principal component analysis (P = <0.01). Division of PA into quartiles demonstrated significant changes in NMR biomarkers in the 2nd - 4th quartiles compared to the 1st quartile representing PA of less than 2850 daily steps (P = 0...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28905144/knee-osteoarthritis-and-associated-cardio-metabolic-clusters-in-a-tertiary-hospital-in-nigeria
#17
Abubakar Yerima, Olufemi Adelowo
Osteoarthritis (OA) of the knee is the most common type of arthritis all over the world. Obesity is the strongest modifiable risk factor and causes OA through a combination metabolic factors and mechanical loading. This study aimed to determine the frequency of metabolic syndrome (Mets) among patients with knee OA and its relationship with pain and functional status. This was a descriptive hospital-based cross-sectional study involving patients with knee OA. Pain was measured using a 0-10 numeric rating visual analog scale (VAS)...
November 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28893184/the-canadian-hiv-and-aging-cohort-study-determinants-of-increased-risk-of-cardio-vascular-diseases-in-hiv-infected-individuals-rationale-and-study-protocol
#18
Madeleine Durand, Carl Chartrand-Lefebvre, Jean-Guy Baril, Sylvie Trottier, Benoit Trottier, Marianne Harris, Sharon Walmsley, Brian Conway, Alexander Wong, Jean-Pierre Routy, Colin Kovacs, Paul A MacPherson, Kenneth Marc Monteith, Samer Mansour, George Thanassoulis, Michal Abrahamowicz, Zhitong Zhu, Christos Tsoukas, Petronela Ancuta, Nicole Bernard, Cécile L Tremblay
BACKGROUND: With potent antiretroviral drugs, HIV infection is becoming a chronic disease. Emergence of comorbidities, particularly cardiovascular disease (CVD) has become a leading concern for patients living with the infection. We hypothesized that the chronic and persistent inflammation and immune activation associated with HIV disease leads to accelerated aging, characterized by CVD. This will translate into higher incidence rates of CVD in HIV infected participants, when compared to HIV negative participants, after adjustment for traditional CVD risk factors...
September 11, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28887067/rush-to-the-fire-fgf21-extinguishes-metabolic-stress-metaflammation-and-tissue-damage
#19
REVIEW
Yongde Luo, Sheng Ye, Xiong Chen, Fanghua Gong, Weiqin Lu, Xiaokun Li
FGF21 is a master regulator of homeostasis of local and systemic lipid, glucose and energy metabolism. Since its discovery a decade ago, significant progress has been made in understanding the basic molecular, cellular and physiological mechanisms underlying its metabolic roles, and characterizing its beneficial pharmacological activities and possible pathological roles in obesity, diabetes, dyslipidemia, fatty liver disease and their collateral complications and tissue damage. Under basal or normal conditions, FGF21 appears to play a dispensable role in metabolism...
August 26, 2017: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/28882918/prevalence-and-clinical-characteristics-of-apparent-therapy-resistant-hypertension-in-patients-with-cardiovascular-disease-a-cross-sectional-cohort-study-in-secondary-care
#20
Esther de Beus, Nicolette G C van der Sande, Michiel L Bots, Wilko Spiering, Michiel Voskuil, Frank L J Visseren, Peter J Blankestijn
OBJECTIVES: Our aim was to investigate the prevalence of apparent therapy-resistant hypertension (aTRH) in patients with clinical manifest cardiovascular disease (CVD), and to study clinical characteristics related to aTRH in this population. SETTING: The SMART (Second Manifestations of ARTerial disease) study is a large, single-centre cohort study in secondary care. PARTICIPANTS: Office blood pressure (BP) at inclusion was used to evaluate BP control in 6191 hypertensive patients with clinical manifest (cardio)vascular disease...
September 6, 2017: BMJ Open
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