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https://www.readbyqxmd.com/read/29453992/serum-cystatin-c-level-is-associated-with-carotid-arterial-wall-elasticity-in-subjects-with-type-2-diabetes-mellitus-a-potential-marker-of-early-stage-atherosclerosis
#1
Rei Kaneko, Shojiro Sawada, Ai Tokita, Rieko Honkura, Noriko Tumura, Shinjiro Kodama, Tomohito Izumi, Kei Takahashi, Kenji Uno, Junta Imai, Tetsuya Yamada, Yukiya Miyachi, Hideyuki Hasegawa, Hiroshi Kanai, Yasushi Ishgaki, Hideki Katagiri
AIMS: Detection of early-stage atherosclerosis in type 2 diabetes mellitus (T2DM) patients is important for preventing cardiovascular disease. A phased tracking method for evaluating arterial wall elasticity sensitively detects early-stage atherosclerosis. However, biochemical markers for early-stage atherosclerosis have yet to be established. METHODS: This cross-sectional study enrolled 180 T2DM patients, who were classified as not having atherosclerosis according to the carotid intima-media thickness (IMT) criteria...
February 14, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29444890/effect-of-gestational-diabetes-and-hypertensive-disorders-of-pregnancy-on-postpartum-cardiometabolic-risk
#2
Ling-Jun Li, Izzuddin M Aris, Lin Lin Su, Yap Seng Chong, Tien Yin Wong, Kok Hian Tan, Jie Jin Wang
AIMS: The cumulative effect of gestational diabetes mellitus (GDM) and hypertensive disorders of pregnancy (HDP) on postpartum cardio-metabolic diseases is equivocal. We aimed to assess the associations of GDM and HDP's individual and synergic contribution to risks of postpartum cardio-metabolic diseases (metabolic syndrome (MetS), abnormal glucose metabolism and hypertension (HTN)). METHODS: Of participants from a Singapore birth cohort, 276 mothers attending the 5-year postpartum visit were included in this study...
February 14, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29444583/barriers-to-a-healthy-lifestyle-for-three-to-four-year-old-children-of-australian-born-and-overseas-born-mothers-with-post-gestational-diabetes-an-australian-qualitative-study
#3
Tehzeeb Zulfiqar, Christopher J Nolan, Cathy Banwell, Rosemary Young, Lynelle Boisseau, Martha Ingle, Fiona E Lithander
Children of mothers affected by gestational diabetes mellitus (GDM) are at higher risk of long-term cardio-metabolic diseases. We explore the diet and physical activity knowledge and practices of Australian-born and overseas-born mothers with GDM history, for their three- to four-year-old children following antenatal health promotion education at a tertiary hospital. We conducted face-to-face, semi-structured interviews with 8 Australian-born and 15 overseas-born mothers with a history of GDM. Findings indicated that mothers of both groups were unaware of the increased health risks of their GDM for their children and could not recall receiving specific dietary or physical activity advice aimed at future child health...
January 1, 2018: Journal of Child Health Care: for Professionals Working with Children in the Hospital and Community
https://www.readbyqxmd.com/read/29439738/dietary-inflammatory-index-a-potent-association-with-cardiovascular-risk-factors-among-patients-candidate-for-coronary-artery-bypass-grafting-cabg-surgery
#4
Mahdieh Abbasalizad Farhangi, Mahdi Najafi
BACKGROUND: Recently, the clinical importance of dietary inflammatory index (DII) in predicting the inflammatory potential of diet and its role in pathogenesis of several chronic disease including some types of cancers, osteoporosis, cardiovascular disease and renal disease has been proposed. However, its association with the disease severity and progression and cardio-metabolic risk factors among patients candidate for coronary artery bypass graft surgery (CABG) has not been evaluated yet...
February 13, 2018: Nutrition Journal
https://www.readbyqxmd.com/read/29433433/epicardial-adipose-tissue-is-related-to-arterial-stiffness-and-inflammation-in-patients-with-cardiovascular-disease-and-type-2-diabetes
#5
Shaween Al-Talabany, Ify Mordi, J Graeme Houston, Helen M Colhoun, Jonathan R Weir-McCall, Shona Z Matthew, Helen C Looker, Daniel Levin, Jill J F Belch, Fiona Dove, Faisel Khan, Chim C Lang
BACKGROUND: Epicardial adipose tissue (EAT) is an emerging cardio-metabolic risk factor and has been shown to correlate with adverse cardiovascular (CV) outcome; however the underlying pathophysiology of this link is not well understood. The aim of this study was to evaluate the relationship between EAT and a comprehensive panel of cardiovascular risk biomarkers and pulse wave velocity (PWV) and indexed left ventricular mass (LVMI) in a cohort of patients with cardiovascular disease (CVD) and diabetes compared to controls...
February 13, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29426298/albuminuria-serum-creatinine-and-estimated-glomerular-filtration-rate-as-predictors-of-cardio-renal-outcomes-in-patients-with-type-2-diabetes-mellitus-and-kidney-disease-a-systematic-literature-review
#6
Keith C Norris, Karen E Smoyer, Catherine Rolland, Jan Van der Vaart, Eliza Beth Grubb
BACKGROUND: Albuminuria, elevated serum creatinine and low estimated glomerular filtration rate (eGFR) are pivotal indicators of kidney decline. Yet, it is uncertain if these and emerging biomarkers such as uric acid represent independent predictors of kidney disease progression or subsequent outcomes among individuals with type 2 diabetes mellitus (T2DM). This study systematically examined the available literature documenting the role of albuminuria, serum creatinine, eGFR, and uric acid in predicting kidney disease progression and cardio-renal outcomes in persons with T2DM...
February 9, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29425212/insulin-resistance-in-lean-and-overweight-non-diabetic-caucasian-adults-study-of-its-relationship-with-liver-triglyceride-content-waist-circumference-and-bmi
#7
Jorge Gonzalez-Cantero, Jose Luis Martin-Rodriguez, Alvaro Gonzalez-Cantero, Juan Pedro Arrebola, Jorge Luis Gonzalez-Calvin
AIMS: Insulin resistance is the pathophysiological precursor of type 2 diabetes mellitus (DM-2), and its relationship with non-alcoholic fatty liver disease (NAFLD) has been widely studied in patients with obesity or metabolic syndrome using not only ultrasound but also liver biopsies or proton magnetic resonance spectroscopy (H1-MRS) to assess liver fat content. In contrast, there are no studies on insulin resistance and NAFLD in lean or overweight Caucasian individuals using H1-MRS or liver biopsies for the quantification of hepatic triglyceride content...
2018: PloS One
https://www.readbyqxmd.com/read/29422041/association-between-empirically-derived-dietary-patterns-with-blood-lipids-fasting-blood-glucose-and-blood-pressure-in-adults-the-india-migration-study
#8
Krithiga Shridhar, Ambika Satija, Preet K Dhillon, Sutapa Agrawal, Ruby Gupta, Liza Bowen, Sanjay Kinra, A V Bharathi, D Prabhakaran, K Srinath Reddy, Shah Ebrahim
BACKGROUND: Dietary patterns (DPs) in India are heterogenous. To date, data on association of indigenous DPs in India with risk factors of nutrition-related noncommunicable diseases (cardiovascular disease and diabetes), leading causes of premature death and disability, are limited. We aimed to evaluate the associations of empirically-derived DPs with blood lipids, fasting glucose and blood pressure levels in an adult Indian population recruited across four geographical regions of India...
February 8, 2018: Nutrition Journal
https://www.readbyqxmd.com/read/29417018/lacunae-in-noncommunicable-disease-control-program-need-to-focus-on-adherence-issues
#9
Tarundeep Singh, Nidhi Bhatnagar, Gopal Singh Moond
Introduction: Chronic non communicable diseases in India have increased in magnitude with earlier onset and more likelihood of complications. Much emphasis is given to early diagnosis and timely treatment. Additionally, tertiary prevention through medication adherence is needed to limit disability and prevent early onset of complications. This study was aimed to assess the magnitude of medication and lifestyle adherence among elderly patients suffering from diabetes and hypertension in rural areas of Punjab...
July 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29410351/fibroblast-growth-factor-21-in-cardio-metabolic-disorders-a-systematic-review-and-meta-analysis
#10
Ishan Lakhani, Mengqi Gong, Wing Tak Wong, George Bazoukis, Konstantinos Lampropoulos, Sunny Hei Wong, William K K Wu, Martin C S Wong, Kwok-Leung Ong, Tong Liu, Gary Tse
BACKGROUND: Fibroblast growth factor 21 is a signalling protein involved in cell differentiation, morphogenesis, proliferation and metabolism. Recent studies have associated increased levels of FGF21 in the development of cardiovascular diseases, whereas others have reported no significant associations. Therefore, this systematic review and meta-analysis evaluated the its value in predicting the risk of cardio-metabolic disorders and mortality. METHODS: PubMed and EMBASE were searched until 5th September 2017 for studies that evaluated the roles of FGF21 levels in cardio-metabolic disorders...
February 1, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29407894/low-sleep-quality-is-associated-with-progression-of-arterial-stiffness-in-patients-with-cardiovascular-risk-factors-hscaa-study
#11
Manabu Kadoya, Masafumi Kurajoh, Miki Kakutani-Hatayama, Akiko Morimoto, Akio Miyoshi, Kae Kosaka-Hamamoto, Takuhito Shoji, Yuji Moriwaki, Masaaki Inaba, Hidenori Koyama
BACKGROUND AND AIMS: Improvement in sleep quality is considered to be a viable target for prevention and treatment of cardiovascular diseases. To gain insight into its underlying mechanisms, we evaluated the significance of objectively measured sleep quality in patients with regard to progression of arterial stiffness over a 3-year follow-up period. METHODS: This prospective cohort study included 306 serial patients registered in the Hyogo Sleep Cardio-Autonomic Atherosclerosis (HSCAA) study...
January 31, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29396691/the-adolescent-cardio-renal-intervention-trial-addit-retinal-vascular-geometry-and-renal-function-in-adolescents-with-type-1-diabetes
#12
Paul Z Benitez-Aguirre, Tien Y Wong, Maria E Craig, Elizabeth A Davis, Andrew Cotterill, Jennifer J Couper, Fergus J Cameron, Farid H Mahmud, Tim W Jones, Lauren A B Hodgson, R Neil Dalton, David B Dunger, Kim C Donaghue
AIMS/HYPOTHESIS: We examined the hypothesis that elevation in urinary albumin creatinine ratio (ACR) in adolescents with type 1 diabetes is associated with abnormal retinal vascular geometry (RVG) phenotypes. METHODS: A cross-sectional study at baseline of the relationship between ACR within the normoalbuminuric range and RVG in 963 adolescents aged 14.4 ± 1.6 years with type 1 diabetes (median duration 6.5 years) screened for participation in AdDIT. A validated algorithm was used to categorise log10 ACR into tertiles: upper tertile ACR was defined as 'high-risk' for future albuminuria and the lower two tertiles were deemed 'low-risk'...
February 2, 2018: Diabetologia
https://www.readbyqxmd.com/read/29392352/epidemiology-of-diabetes-and-diabetic-complications-in-china
#13
REVIEW
Ronald C W Ma
The People's Republic of China (herein referred to as China) has witnessed one of the most dramatic rises in diabetes prevalence anywhere in the world. The latest epidemiological study suggests that approximately 11% of the population has diabetes, with a significant proportion remaining undiagnosed. Risk factors for diabetes in the Chinese population are similar to those in other populations, though gestational diabetes and young-onset diabetes is becoming increasingly common. Data on the prevalence of diabetic complications remain limited, though cardio-renal complications account for significant morbidity and mortality...
February 1, 2018: Diabetologia
https://www.readbyqxmd.com/read/29387815/a-randomized-controlled-trial-to-evaluate-the-effects-of-high-p-rotein-c-omplete-l-a-cto-ve-geta-r-ian-pacer-diet-in-non-diabetic-obese-asian-indians-in-north-india
#14
Swati Bhardwaj, Anoop Misra, Seema Gulati, Shajith Anoop, Vineet Kumar Kamal, Ravindra Mohan Pandey
In view of the increasing prevalence of obesity in largely vegetarian Asian Indians, it is important to research a high protein, low carbohydrate vegetarian diet. The present study was designed to evaluate the effects of a "High P rotein C omplete (lacto) V E geta R ian Diet (Acronym; 'PACER diet'), on weight, body composition and metabolic profiles in non-diabetic obese Asian Indians living in north India. In this 8-week randomized control trial, 102 vegetarian subjects with body mass index (BMI) >25 kg/m 2 were randomized to either a test diet (PACER diet; high protein, high fat and moderately low carbohydrate, lacto-vegetarian diet) or control diet (standard vegetarian diet formulated as the dietary guidelines for Asian Indians) after 4 weeks of diet and exercise run-in period...
December 2017: Heliyon
https://www.readbyqxmd.com/read/29384050/polyphenols-potential-use-in-the-prevention-and-treatment-of-cardiovascular-diseases
#15
Rosaria Vincenza Giglio, Angelo Maria Patti, Arrigo Fg Cicero, Giuseppe Lippi, Manfredi Rizzo, Peter P Toth, Maciej Banach
BACKGROUND: Polyphenols are bioactive compounds that can be found mostly in foods like fruits, cereals, vegetables, dry legumes, chocolate and beverages such as coffee, tea and wine. They are extensively used in the prevention and treatment of cardiovascular disease (CVD) providing protection against many chronic illnesses. Their effects on human health depend on the amount consumed and on their bioavailability. Many studies have demonstrated that polyphenols have also good effects on the vascular system by lowering blood pressure, improving endothelial function, increasing antioxidant defences, inhibiting platelet aggregation and low-density lipoprotein oxidation, and reducing inflammatory responses...
January 29, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29384012/nurse-led-diabetic-retinopathy-screening-a-pilot-study-to-evaluate-a-new-approach-to-vision-care-for-canadian-aboriginal-peoples
#16
Shelley Spurr, Carol Bullin, Jill Bally, Krista Trinder, Shahab Khan
Diabetic retinopathy is the most common cause of new cases of blindness and is pandemic among Aboriginal people around the world. To reduce health inequities, accessible vision screening among these high-risk populations is essential. To assess cardio-metabolic co-morbidities associated with type 2 diabetes and the use of a portable fundus camera as a novel approach for convenient, earlier and more accessible vision screening for Aboriginal peoples living with type 2 diabetes in northern and remote Canadian communities...
December 2018: International Journal of Circumpolar Health
https://www.readbyqxmd.com/read/29381982/metabolic-acidosis-of-chronic-kidney-disease-and-subclinical-cardiovascular-disease-markers-friend-or-foe
#17
Cristina Căpuşă, Gabriel Ştefan, Simona Stancu, Mariana Lipan, Lilach Daniel Tsur, Gabriel Mircescu
The effect of chronic metabolic acidosis (MA) on cardiovascular disease (CVD) in the setting of chronic kidney disease (CKD) is largely unknown. Therefore, we aimed to study this relationship in nondialysis CKD patients.This cross-sectional, single-center study prospectively enrolled 95 clinically stable CKD patients (median age 61 (58, 65) years, 60% male, median eGFR 27 (22, 32) mL/min). Data on CKD etiology, CVD history, CVD traditional, and nontraditional risk factors were obtained. Also, markers of subclinical CVD were assessed: intima-media thickness (IMT), abdominal aortic calcifications (Kauppila score-AACs), cardio-ankle vascular index (CAVI), ankle-brachial index (ABI), ejection fraction, and interventricular septum thickness...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29371333/mechanisms-in-endocrinology-sglt2-inhibitors-clinical-benefits-by-restoration-of-normal-diurnal-metabolism
#18
Russell L Esterline, Allan Vaag, Jan Oscarsson, Jiten Vora
Type 2 diabetes (T2D) is associated with inhibition of autophagic and lysosomal housekeeping processes that detrimentally affect key organ functioning; a process likely to be exacerbated by conventional insulin-driven anabolic therapies. We propose that the cardio-renal benefits demonstrated with sodium-glucose cotransporter-2 inhibitor (SGLT2i) treatment in T2D partly may be explained by their ability to drive consistent, overnight periods of increased catabolism brought about by constant glucosuria. Key steps driving this catabolic mechanism include: a raised glucagon/insulin ratio initially depleting glycogen in the liver and ultimately activating gluconeogenesis utilizing circulating amino acids (AAs); a general fuel switch from glucose to free fatty acids (accompanied by a change in mitochondrial morphology from a fission to a sustained fusion state driven by a decrease in AA levels); a decrease in circulating AAs and insulin driving inhibition of mammalian target of rapamycin complex 1 (mTORC1), which enhances autophagy/lysosomal degradation of dysfunctional organelles, eventually causing a change in mitochondrial morphology from a fission to a sustained fusion state...
January 25, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29368442/improved-insulin-sensitivity-and-secretion-in-pre-diabetic-patients-with-adrenal-insufficiency-on-dual-release-hydrocortisone-treatment-a-36-month-retrospective-analysis
#19
Valentina Guarnotta, Alessandro Ciresi, Giuseppe Pillitteri, Carla Giordano
OBJECTIVE: Dual-release hydrocortisone (DR-HC) provides physiological cortisol exposure, leading to an improvement of anthropometric and metabolic parameters. The aim of the study was to evaluate the effects of DR-HC on insulin secretion and sensitivity and cardio metabolic risk, indirectly expressed by the visceral adiposity index (VAI). DESIGN AND PATIENTS: Retrospective analysis of 49 patients, 13 with primary and 36 with secondary adrenal insufficiency (AI) respectively, on conventional glucocorticoid treatment at baseline and switched to DR-HC for 36 months...
January 25, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29364583/incretins-beyond-type-2-diabetes
#20
REVIEW
Paresh Dandona, Husam Ghanim, Ajay Chaudhuri
While the use of incretins, including GLP-1 receptor agonists and PDD-IV inhibitors, is well established in the treatment of type 2 diabetes, many other aspects of these agents are yet to be discovered and utilized for their potential clinical benefit. These include the potential role of GLP-1 receptor agonists in the induction of weight loss, blood pressure reduction, anti-inflammatory and nephro- and cardio-protective actions. Their potential benefit in type 1 diabetes is also being investigated. This review will attempt to comprehensively describe novel discoveries in the field of incretin pathophysiology and pharmacology beyond their classical role in the treatment of type 2 diabetes...
February 2018: Diabetes, Obesity & Metabolism
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