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https://www.readbyqxmd.com/read/28818261/contemporary-medical-therapies-of-atherosclerotic-carotid-artery-disease
#1
Suk F Cheng, Martin M Brown
Contemporary medical therapy consists of identification and treatment of all patient-modifiable vascular risk factors. Specific atherosclerotic disease therapies are designed to reduce the risk of thrombosis, and the disease progression in order to reduce the risk of future cardiovascular events. Contemporary medical management emphasizes the need to support the patient in achieving lifestyle modifications and to adjust medication to achieve individualized target values for specific quantifiable risk factors...
March 2017: Seminars in Vascular Surgery
https://www.readbyqxmd.com/read/28812915/kardiovize-brno-2030-a-prospective-cardiovascular-health-study-in-central-europe-methods-baseline-findings-and-future-directions
#2
Narine K Movsisyan, Manlio Vinciguerra, Francisco Lopez-Jimenez, Šárka Kunzová, Martin Homolka, Jana Jaresova, Renata Cífková, Ondřej Sochor
Background Atherosclerotic cardiovascular disease is highly prevalent in Eastern and Central Europe, where the incidence is the highest in the world. The Kardiovize Brno 2030 study was designed as a prospective cohort study to investigate the complex relationships of cardiovascular disease and outcomes with a range of biological, psychosocial, environmental, behavioral, and economic factors in an urban population of the Czech Republic. Methods We randomly selected a 1% sample of the city of Brno residents aged 25-64 years stratified by sex and age...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28809368/deep-neck-infections-a-single-center-analysis-of-63-cases
#3
P Kauffmann, R Cordesmeyer, M Tröltzsch, C Sömmer, R Laskawi
BACKGROUND AND PURPOSE: With the use of antibiotic therapy, the incidence of deep neck infections has decreased in recent decades. The aim of this investigation was to review the clinical course and the management of deep neck infections in our department, compare them to the experiences of the common literature and identify predisposing factors for lethal complications. MATERIAL AND METHODS: In this single-center analysis, 63 patients with deep neck infections were treated surgically...
August 15, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/28792455/cardio-metabolic-benefits-of-plant-based-diets
#4
REVIEW
Hana Kahleova, Susan Levin, Neal Barnard
Cardio-metabolic disease, namely ischemic heart disease, stroke, obesity, and type 2 diabetes, represent substantial health and economic burdens. Almost one half of cardio-metabolic deaths in the U.S. might be prevented through proper nutrition. Plant-based (vegetarian and vegan) diets are an effective strategy for improving nutrient intake. At the same time, they are associated with decreased all-cause mortality and decreased risk of obesity, type 2 diabetes, and coronary heart disease. Evidence suggests that plant-based diets may reduce the risk of coronary heart disease events by an estimated 40% and the risk of cerebral vascular disease events by 29%...
August 9, 2017: Nutrients
https://www.readbyqxmd.com/read/28792230/exercise-capacity-and-haemodynamic-response-among-12-327-individuals-with-cardio-metabolic-risk-factors-undergoing-treadmill-exercise
#5
Christina Chrysohoou, John Skoumas, Georgios Georgiopoulos, Catherine Liontou, Georgia Vogiatzi, Konstantinos Tsioufis, Stamatios Lerakis, Dimitrios Soulis, Christos Pitsavos, Dimitris Tousoulis
Aims Haemodynamic parameters during and after exercise test seem to have a role in predicting cardiovascular events. We sought to evaluate the potential different responses in exercise capacity, heart rate and blood pressure levels in relation to major cardiovascular disease risk factors, among individuals undergoing exercise tolerance testing. Methods and results Consecutive individuals ( N = 12,327), aged 55 ± 11.8 years, underwent exercise tolerance testing, using the Bruce protocol. Obese participants showed higher values of peak systolic and diastolic blood pressure ( p < 0...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28790929/combined-interval-training-and-post-exercise-nutrition-in-type-2-diabetes-a-randomized-control-trial
#6
Monique E Francois, Cody Durrer, Kevin J Pistawka, Frank A Halperin, Courtney Chang, Jonathan P Little
Background: High-intensity interval training (HIIT) can improve several aspects of cardiometabolic health. Previous studies have suggested that adaptations to exercise training can be augmented with post-exercise milk or protein consumption, but whether this nutritional strategy can impact the cardiometabolic adaptations to HIIT in type 2 diabetes is unknown. Objective: To determine if the addition of a post-exercise milk or protein beverage to a high-intensity interval training (HIIT) intervention improves cardiometabolic health in individuals with type 2 diabetes...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28769070/il6r-haplotype-rs4845625-t-rs4537545-c-is-a-risk-factor-for-simultaneously-high-crp-ldl-and-apob-levels
#7
A A Arguinano, E Naderi, N C Ndiaye, M Stathopoulou, S Dadé, B Alizadeh, S Visvikis-Siest
Interleukin 6 receptor (IL-6R), mediating IL-6's biological functions, plays an important role in different diseases such as diabetes, obesity and cardio-vascular diseases. In this study, we investigated the effects of two single nucleotide polymorphisms (SNPs), within the IL-6R loci, previously associated with C-reactive protein (CRP) and coronary heart diseases risk, and with controversial effects on lipids traits: SNP rs4845625 and SNP rs4537545. The results showed that both investigated SNPs were antagonistically related with CRP levels; the minor rs4845625*T allele was associated with increased CRP levels (P-value=0...
August 3, 2017: Genes and Immunity
https://www.readbyqxmd.com/read/28767993/physical-activity-in-brazil-lessons-from-elsa-brasil-narrative-review
#8
Francisco José Gondim Pitanga, Maria Conceição Chagas Almeida, Ciro Oliveira Queiroz, Estela Maria Leão de Aquino, Sheila Maria Alvim Matos
CONTEXT AND OBJECTIVE: The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) was conducted among civil servants at six higher education institutions located in six Brazilian state capitals. The objective of this review was to identify the publications produced within the scope of ELSA-Brasil that analyzed the participants' physical activity. DESIGN AND SETTING: Review study using baseline data from ELSA-Brasil. METHODS: Narrative review of Brazilian studies on physical activity produced using data from ELSA-Brasil participants...
July 2017: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/28746811/the-acute-effects-of-different-spironolactone-doses-on-cardiac-function-in-streptozotocin-induced-diabetic-rats
#9
Aleksandra Vranic, Stefan Simovic, Petar Ristic, Tamara R Nikolic, Isidora Stojic, Ivan M Srejovic, Vladimir I Zivkovic, Vladimir Jakovljevic, Dusan Djuric
Currently, cardiovascular diseases are leading cause of global mortality, while diabetes mellitus remains an important cause of cardiovascular morbidity. Findings suggest that obesity and diabetes mellitus are closely interconnected with high aldosterone levels, while mineralocorticoid receptors antagonist therapy has shown positive effects on cardiovascular complications associated with diabetes mellitus. A recent study showed that patients with diabetes mellitus treated with mineralocorticoid receptors antagonist have improved coronary microvascular function, leading to improved diastolic dysfunction...
July 26, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28727855/association-of-apoe-gene-polymorphism-with-lipid-profile-and-coronary-artery-disease-in-afro-caribbeans
#10
Laurent Larifla, Christophe Armand, Jacqueline Bangou, Anne Blanchet-Deverly, Patrick Numeric, Christiane Fonteau, Carl-Thony Michel, Séverine Ferdinand, Véronique Bourrhis, Fritz-Line Vélayoudom-Céphise
OBJECTIVES: Apolipoprotein E gene (APOE) polymorphism is associated with the lipid profile and cardio-vascular disease. However, these relationships vary between ethnic groups. We evaluated, for the first time in an Afro-Caribbean population, the distribution of APOE polymorphisms and their associations with coronary artery disease (CAD), the lipid profile and other cardio-metabolic risk factors. METHODS: We studied 712 Afro-Caribbean subjects including 220 with documented CAD and 492 healthy subjects...
2017: PloS One
https://www.readbyqxmd.com/read/28725323/the-elevation-of-cardio-ankle-vascular-index-in-a-patient-with-malignant-lymphoma-treated-with-a-combination-therapy-of-rituximab-and-cyclophosphamide-doxorubicin-vincristine-and-prednisolone
#11
Naomi Shimizu, Noriko Ban, Yasuhiro Watanabe, Asami Rikitake, Rena Watanabe, Sho Tanaka, Yuta Sato, Haruki Imamura, Hidetoshi Kawana, Takashi Yamaguchi, Atsuhito Saiki, Ichiro Tatsuno, Kohji Shirai
An increased risk of arteriosclerosis has been noted in cancer survivors. Currently, there are only a few reports available that consider the risk of arteriosclerosis in patients treated with chemotherapy. Patients with an advanced stage B-cell malignant lymphoma are typically treated with a combination therapy of rituximab and cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP). Complications such as diabetes mellitus (DM), hyperlipidemia (HL), and osteoporosis due to prednisolone and cardiotoxicity due to anthracyclines are well known...
August 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28715448/effect-of-synergistic-interaction-between-abnormal-adiposity-related-metabolism-and-prediabetes-on-microalbuminuria-in-the-general-population
#12
Jong Wook Choi, Il Hwan Oh, Chang Hwa Lee, Joon-Sung Park
Central obesity and related metabolic components are important risks for microalbuminuria. To describe the effects of interactions between central obesity and related metabolic components on microalbuminuria, we conducted a nation-wide, population-based interaction analysis using cardio-metabolic index (CMI) as a candidate indicator of central obesity and related abnormal lipid metabolism. We recruited native Koreans aged 20 years or older with no medical illness. A total of 5398 participants were divided into quintiles according to CMI with sex as a covariate factor...
2017: PloS One
https://www.readbyqxmd.com/read/28715069/impact-of-diabetes-on-association-between-epicardial-fat-thickness-and-extent-and-complexity-of-coronary-artery-disease-in-patients-with-non-st-elevation-myocardial-infarction
#13
Taner Seker, Caner Turkoglu, Hazar Harbalıoglu, Mustafa Gur
BACKGROUND: Epicardial fat thickness (EFT) is associated with increased cardio metabolic risk. Recent studies have suggested that there is a strong relationship between diabetes and EFT. Although the relationship between EFT and coronary artery disease (CAD) is well known, the possible impact of diabetes on the relationship between EFT and extent and complexity of CAD was not fully investigated. AIM: We aimed to investigate the relationship between EFT and extent and complexity of CAD in patients with non-ST elevation myocardial infarction (NSTEMI) with and without diabetes...
July 17, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28713160/pathogenic-roles-of-microvesicles-in-diabetic-retinopathy
#14
REVIEW
Wei Zhang, Song Chen, Ming-Lin Liu
Diabetic retinopathy (DR) is a common complication of diabetes and has been recognized as the leading cause of blindness in adults. Several interrelated molecular pathways are involved in the development of DR. Microvesicles (MVs) are cell membrane vesicles, which carry many biologic molecules, such as mRNAs, microRNAs, transcription factors, membrane lipids, membrane receptors, and other proteins. They may be involved in intercellular communication that can promote inflammation, angiogenesis, and coagulation...
July 17, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28701674/resveratrol-ameliorates-arterial-stiffness-assessed-by-cardio-ankle-vascular-index-in-patients-with-type-2-diabetes-mellitus
#15
RANDOMIZED CONTROLLED TRIAL
Haruki Imamura, Takashi Yamaguchi, Daiji Nagayama, Atsuhito Saiki, Kohji Shirai, Ichiro Tatsuno
Resveratrol has been reported to have potent anti-atherosclerotic effects in animal studies. However, there are few interventional studies in human patients with atherosclerogenic diseases. The cardio-ankle vascular index (CAVI) reflects arterial stiffness and is a clinical surrogate marker of atherosclerosis. The aim of the present study was to investigate the effect of resveratrol on arterial stiffness assessed by CAVI in patients with type 2 diabetes mellitus (T2DM).In this double-blind, randomized, placebo-controlled study, 50 patients with T2DM received supplement of a 100mg resveratrol tablet (total resveratrol: oligo-stilbene 27...
August 3, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28701285/association-of-divalent-cations-and-insulin-resistance-with-thyroid-hormones-in-patients-with-type-2-diabetes-mellitus
#16
Rajendran Jayanthi, Abu Raghavan Srinivasan, Niranjan Gopal, Ramesh Ramaswamy
AIM: The study was primarily aimed at investigating the association of Magnesium and Zinc levels in the serum of adult Non- obese and Obese type 2 diabetic patients, with particular reference to thyroid comorbidity. METHODS: 108 patients with T2DM of both genders (24 Non obese and 84 Obese) were enrolled from a tertiary health care unit in Puducherry. The cardio-metabolic risk factors were assessed through body mass index, Waist hip ratio, blood pressure, fasting blood glucose, lipid profile and glycated haemoglobin...
July 3, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28700904/inhibition-of-high-glucose-induced-inflammation-and-fibrosis-by-a-novel-curcumin-derivative-prevents-renal-and-heart-injury-in-diabetic-mice
#17
Hongjin Chen, Xi Yang, Kongqin Lu, Chun Lu, Yunjie Zhao, Suqing Zheng, Jieli Li, Zhangjian Huang, Yi Huang, Yali Zhang, Guang Liang
Hyperglycemia-induced inflammation and fibrosis have important roles in the pathogenesis of diabetic nephropathy and cardiomyopathy. With inflammatory cytokines and signaling pathways as important mediators, targeting inflammation may be an effective approach to new avenue for treating diabetic complications. J17, a molecule with structural similarities to curcumin, exhibited good anti-inflammatory activities by inhibiting LPS-induced inflammatory response in macrophages. However, its ability to alleviate hyperglycemia-induced injury via its anti-inflammatory actions remained unclear...
August 15, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28700893/coronary-microvascular-disease-as-an-early-culprit-in-the-pathophysiology-of-diabetes-and-metabolic-syndrome
#18
REVIEW
Hicham Labazi, Aaron J Trask
Metabolic syndrome (MetS) is a group of cardio-metabolic risk factors that includes obesity, insulin resistance, hypertension, and dyslipidemia; these are also a combination of independent coronary artery disease (CAD) risk factors. Alarmingly, the prevalence of MetS risk factors are increasing and a leading cause for mortality. In the vasculature, complications from MetS and type 2 diabetes (T2D) can be divided into microvascular (retinopathy and nephropathy) and macrovascular (cardiovascular diseases and erectile dysfunction)...
July 9, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28686204/metabolic-and-blood-pressure-effects-of-walnut-supplementation-in-a-mouse-model-of-the-metabolic-syndrome
#19
Nicola J A Scott, Leigh J Ellmers, Anna P Pilbrow, Lotte Thomsen, Arthur Mark Richards, Chris M Frampton, Vicky A Cameron
There is extensive evidence that walnut consumption is protective against cardiovascular disease and diabetes in the healthy population, but the beneficial effects of walnut consumption in individuals with the metabolic syndrome (MetS) remain uncertain. We compared a range of cardio-metabolic traits and related tissue gene expression associated with 21 weeks of dietary walnut supplementation in a mouse model of MetS (MetS-Tg) and wild-type (WT) mice (n = 10 per genotype per diet, equal males and females). Compared to standard diet, walnuts did not significantly alter food consumption or body weight trajectory of either MetS-Tg or WT mice...
July 7, 2017: Nutrients
https://www.readbyqxmd.com/read/28682028/-the-uric-acid-cardio-nephropathy
#20
Francesca Viazzi, Barbara Bonino, Francesca Cappadona, Roberto Pontremoli
Uric acid is a product of purine catabolism formed by the activity of xanthine-oxidase and prevalently excreted by the kidney. In vivo, urate is known to have both an anti- or pro-oxidant role depending on several biological conditions. New evidence suggests that chronic hyperuricemia can contribute to hypertension development, kidney disease and cardiovascular risk. The pathophysiologic mechanisms are various, such as endothelial dysfunction and oxidative stress, vasoconstriction and stimulation of renin angiotensin system...
March 2017: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
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