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https://www.readbyqxmd.com/read/29655953/risk-factors-predisposing-to-acute-coronary-syndromes-in-young-women-%C3%A2-45-years-of-age
#1
Maciej Bęćkowski, Marek Gierlotka, Mariusz Gąsior, Lech Poloński, Tomasz Zdrojewski, Rafał Dąbrowski, Jarosław Karwowski, Ilona Kowalik, Wojciech Drygas, Hanna Szwed
BACKGROUND: Acute coronary syndromes (ACS) are rare in young women. The purpose of this study was to characterize risk factors (RF) predisposing to ACS in young women and evaluate possible age-related differences. METHODS AND RESULTS: We studied 1941 young women with ACS aged ≤45 years (≤45ACS) from the PL-ACS registry and compared them with two control groups: 4275 women aged 63-64 years with ACS (63-64ACS) from the PL-ACS registry and 1170 young healthy women aged ≤45 years (≤45H) without confirmed coronary artery disease (CAD), from two national, representative, cross-sectional population health surveys, NATPOL 2011 and WOBASZ...
April 4, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29650978/percutaneous-closure-of-left-atrial-appendage-significantly-affects-lipidome-metabolism
#2
G Yücel, M Behnes, C Barth, A Wenke, B Sartorius, K Mashayekhi, B Yazdani, T Bertsch, J Rusnak, A Saleh, U Hoffmann, C Fastner, S Lang, X Zhou, K Sattler, M Borggrefe, I Akin
Patients with non-valvular atrial fibrillation (AF) and a high risk for oral anticoagulation can be treated by percutaneous implantation of left atrial appendage occlusion devices (LAAC) to reduce the risk of cardio-embolic stroke. This study evaluates whether LAAC may influence lipid metabolism, which has never been investigated before. Patients with successful LAAC were included consecutively. Venous peripheral blood samples of patients were collected immediately before (T0, baseline) and 6 months after (T1, mid-term) LAAC...
April 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29629375/arterial-stiffness-is-associated-with-peripheral-sensory-neuropathy-in-diabetes-patients-in-ghana
#3
Kwame Yeboah, Jennifer A Agyekum, Richard N A Owusu Mensah, Patrick K Affrim, Linda Adu-Gyamfi, Rita O Doughan, Afua B Adjei
Objective: Peripheral sensory neuropathy (PSN) is among microvascular complications of diabetes that make patients prone to ulceration and amputation. Arterial stiffness is a predictor of cardiovascular diseases and microvascular complications associated with diabetes. We investigated the association between PSN and arterial stiffness, measured as aortic pulse wave velocity (PWVao) and cardio-ankle vascular index (CAVI). Method: In a case-control design, arterial stiffness was measured in 240 diabetes patients and 110 nondiabetic control...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29625944/prophylactic-mechanisms-of-cucumis-melo-var-flexuosus-and-phoenix-dactylifera-fruit-extracts-against-diabetic-cardiomyopathy-in-streptozotocin-induced-diabetic-rats
#4
Amna Ali Saddi, Azza Mostafa Mohamed, Abdulkader Mohamed Shaikh
The aim of this investigation was to study the antidiabetic impact of Cucumis melo var. flexuosus and/or Phoenix dactylifera fruit aqueous extracts and their mechanisms in repressing diabetes induced cardio-myopathy in diabetic rats. Type 2 diabetes was promoted in rats by a single intraperitoneal injection of streptozotocin (30mg/kg body wight). C. flexuosus and P. dactylifera extracts (200mg/kg body weight, each) were ingested to diabetic rats daily for a month. The results showed that ingestion of either plant extract or their combination to diabetic rats significantly diminished the glucose level and boosted the insulin concentration in the blood...
March 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29625939/ameliorative-effect-of-hydro-methanolic-extract-from-roots-of-rauwolfia-serpentina-on-some-biochemical-parameters-of-type-1-diabetic-mice
#5
Muhammad Bilal Azmi, Shamim A Qureshi, Syed Danish Haseen Ahmed, Hina Akram Mudassir, Fauzia Imtiaz, Sumera Rais, Auwais Ahmed Khan, Muhammad Ahsan
Present work seeks to investigate the biochemical parameters in terms of hypoglycemic and hypolipidemic effects of hydro-methanolic roots extract (HyMREt) of Rauwolfia serpentina in type 1 (alloxan induced) diabetic mice. Animals were divided into seven groups, four control groups, and three were test groups (HyMREt at 50, 100, & 150mg/kg). Each treatment was repeated for 14 days regularly in all seven respective groups and afterwards the body weights, fasting blood glucose (FBG), insulin, and serum lipid levels were determined...
March 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29617330/fermented-food-and-non-communicable-chronic-diseases-a-review
#6
REVIEW
Doreen Gille, Alexandra Schmid, Barbara Walther, Guy Vergères
Fermented foods represent a significant fraction of human diets. Although their impact on health is positively perceived, an objective evaluation is still missing. We have, therefore, reviewed meta-analyses of randomized controlled trials (RCT) investigating the relationship between fermented foods and non-transmissible chronic diseases. Overall, after summarizing 25 prospective studies on dairy products, the association of fermented dairy with cancer was found to be neutral, whereas it was weakly beneficial, though inconsistent, for specific aspects of cardio-metabolic health, in particular stroke and cheese intake...
April 4, 2018: Nutrients
https://www.readbyqxmd.com/read/29615543/intermittent-hypoxia-induces-beneficial-cardiovascular-remodeling-in-left-ventricular-function-of-type-1-diabetic-rat
#7
Fırat Akat, Hakan Fıçıcılar, Ayşegül Durak, Erkan Tuncay, Ali Doğan Dursun, Ferda Topal Çelikkan, Bizden Sabuncuoğlu, Belma Turan, Metin Baştuğ
OBJECTIVE: Depressed mechanical activity is a marked complication in diabetics. Hypoxia has properties for novel diagnostic and therapeutic strategies, while intermittent hypoxia (IH) provides early functional and histologic remodeling, including some cardio benefits in early hemodynamic alterations with histologic remodeling and delayed changes in peripheral vasoreactivity. Therefore, we aimed to examine whether IH application presents a cardioprotective effect, via stabilization of hypoxia-inducible factor (HIF) in streptozotocin (STZ)-induced diabetic rat heart...
April 2018: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/29615288/cardiac-effects-of-fish-oil-in-a-rat-model-of-streptozotocin-induced-diabetes
#8
F Mayyas, R Jaradat, K H Alzoubi
BACKGROUND AND AIMS: Fish oil (FO) is rich in omega-3 polyunsaturated fatty acids, which have cardio-protective effects. This study aims to evaluate effects of FO in a rat model of streptozotocin (STZ) induced diabetes. METHODS AND RESULTS: Adults male Wistar rats were assigned to control (4 μl corn oil/g corn oil given by oral gavage), FO (4 μl Menhaden FO/g body weight given by oral gavage), diabetes (DM, 35 mg/kg STZ single intraperitoneal injection, corn oil), and DM + FO groups for 8 weeks...
February 25, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29608593/heart-rate-dynamics-during-cardio-pulmonary-exercise-testing-are-associated-with-glycemic-control-in-individuals-with-type-1-diabetes
#9
Othmar Moser, Max L Eckstein, Olivia McCarthy, Rachel Deere, Stephen C Bain, Hanne L Haahr, Eric Zijlstra, Tim Heise, Richard M Bracken
INTRODUCTION: This study investigated the degree and direction (kHR) of the heart rate to performance curve (HRPC) during cardio-pulmonary exercise (CPX) testing and explored the relationship with diabetes markers, anthropometry and exercise physiological markers in type 1 diabetes (T1DM). MATERIAL AND METHODS: Sixty-four people with T1DM (13 females; age: 34 ± 8 years; HbA1c: 7.8 ± 1% (62 ± 13 mmol.mol-1) performed a CPX test until maximum exhaustion. kHR was calculated by a second-degree polynomial representation between post-warm up and maximum power output...
2018: PloS One
https://www.readbyqxmd.com/read/29605673/high-fat-diet-exacerbates-early-psoriatic-skin-inflammation-independent-of-obesity-saturated-fatty-acids-as-key-players
#10
Diana Herbert, Sandra Franz, Yulia Popkova, Ulf Anderegg, Jürgen Schiller, Katharina Schwede, Axel Lorz, Jan C Simon, Anja Saalbach
In obesity, hypertrophic adipocytes secret high amounts of adipocytokines resulting in low-grade inflammation- amplified by infiltrating pro-inflammatory macrophages, oxidative stress, hypoxia and lipolysis. It is known, that these chronic pro-inflammatory conditions support the development of type II diabetes and cardio vascular diseases, while mechanisms of obesity-related exacerbation of inflammatory skin disorders like psoriasis are unclear. In this study, we uncover nutritional saturated fatty acids (SFAs) as major risk factors for the amplification of skin inflammation, independent of obesity-related parameters, like fat mass extension, adipocytokines and glucose homeostasis...
March 29, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29605421/change-in-physical-activity-and-accumulation-of-cardiometabolic-risk-factors
#11
Tuija Leskinen, Sari Stenholm, Olli J Heinonen, Anna Pulakka, Ville Aalto, Mika Kivimäki, Jussi Vahtera
This study aims to examine the association between change in physical activity levels over time and accumulation of cardiometabolic risk factors. Four consecutive surveys (Time 1 to 4) were conducted with 4-year intervals in 1997-2013 (the Finnish Public Sector study). Physical activity of 15,634 cardio-metabolically healthy participants (mean age 43.3 (SD 8.7) years, 85% women) was assessed using four-item survey measure and was expressed as weekly metabolic equivalent (MET) hours in Time 1, 2, and 3. At each time point, participants were categorised into low (<14 MET-h/week), moderate (≥14 to <30 MET-h/week), or high (≥30 MET-h/week) activity level and change in physical activity levels between Time 1 and 3 (over 8-years) was determined...
March 29, 2018: Preventive Medicine
https://www.readbyqxmd.com/read/29593130/nonhuman-primate-breath-volatile-organic-compounds-associate-with-developmental-programming-and-cardio-metabolic-status
#12
Andrew C Bishop, Mark Libardoni, Ahsan Choudary, Biswapriya Biswavas Misra, Kenneth Lange, John Bernal, Mark Nijland, Cun Li, Michael Olivier, Peter W Nathanielsz, Laura A Cox
Rodent and nonhuman primate (NHP) studies indicate that developmental programming by reduced perinatal nutrition negatively impacts life course cardio-metabolic health. We have developed a baboon model in which we feed control mothers (CON) ad libitum while nutrient restricted mothers are fed 70% of ad libitum global feed in pregnancy and lactation. Offspring of nutrient restricted mothers are intrauterine growth restricted (IUGR) at term. By 3.5 years IUGR baboons showed signs of insulin resistance, indicating a pre-diabetic phenotype, in contrast to healthy CON offspring...
March 29, 2018: Journal of Breath Research
https://www.readbyqxmd.com/read/29588472/osteoarthritis-patterns-cardio-metabolic-risk-factors-and-risk-of-all-cause-mortality-20-years-follow-up-in-patients-after-hip-or-knee-replacement
#13
G Büchele, K P Günther, H Brenner, W Puhl, T Stürmer, D Rothenbacher, R E Brenner
Osteoarthritis (OA) is a common musculoskeletal disorder and occur in different patterns. However, its impact on long-term all-cause-mortality is inconclusive. STUDY AIMS: Investigate 20-year all-cause-mortality in patients with hip/knee arthroplasty (recruited 1995/1996, N = 809) from the Ulm Osteoarthritis Study-cohort, in comparison to general population. Furthermore, to enlighten the triangle between baseline life-style and cardio-metabolic risk factors, phenotypic OA-patterns (laterality, generalization, cause) and all-cause-mortality...
March 27, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29587288/effect-of-sodium-thiosulfate-on-arterial-stiffness-in-end-stage-renal-disease-patients-undergoing-chronic-hemodialysis-sodium-thiosulfate-hemodialysis-study-a-randomized-controlled-trial
#14
Donlawat Saengpanit, Pairoj Chattranukulchai, Monravee Tumkosit, Monchai Siribumrungwong, Pisut Katavetin, Visith Sitprija, Kearkiat Praditpornsilpa, Somchai Eiam-Ong, Paweena Susantitaphong
BACKGROUND: Arterial stiffness (AS) and vascular calcification are significantly related to a high cardiovascular mortality risk in hemodialysis (HD) patients. Intravenous sodium thiosulfate (IV STS) can prevent and delay the vascular calcification progression in uremic states; however, the STS effect on AS has not been assessed. This study aimed to evaluate the STS efficacy on vascular calcification and AS in HD patients. METHODS: Fifty HD patients with abnormal AS, as measured via the cardio-ankle vascular index (CAVI ≥8), were prospectively randomized to open-label 12...
March 23, 2018: Nephron
https://www.readbyqxmd.com/read/29577540/burden-of-cardio-renal-metabolic-conditions-in-adults-with-type-2-diabetes-within-the-diabetes-collaborative-registry
#15
Suzanne V Arnold, Mikhail Kosiborod, Jingyan Wang, Peter Fenici, Goran Gannedahl, Robert J LoCasale
We examined the prevalence of cardio-renal-metabolic (CaReMe) conditions and their combinations among 530,747 adults with type 2 diabetes in a US-based outpatient registry of 271 primary care, cardiology, and endocrinology offices. We evaluated the following CaReMe conditions: hypertension, hyperlipidemia, coronary artery disease (CAD), chronic kidney disease (CKD), cerebrovascular disease, peripheral artery disease, atrial fibrillation, heart failure, and gout or hyperuricemia; prevalence estimates were adjusted based on the distribution of diabetes by age in the 2015 US population...
March 25, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29576367/association-of-dietary-and-serum-magnesium-with-glucose-metabolism-markers-the-furukawa-nutrition-and-health-study
#16
Shamima Akter, Masafumi Eguchi, Akiko Nanri, Takeshi Kochi, Ikuko Kashino, Keisuke Kuwahara, Huanhuan Hu, Takako Miki, Isamu Kabe, Tetsuya Mizoue
BACKGROUND & AIMS: Magnesium may play an important role in cardio-metabolic abnormalities, including type 2 diabetes, but epidemiological evidence linking magnesium status to glucose metabolism is limited among Asians. We cross-sectionally examined the association of dietary and serum magnesium with markers of glucose metabolism among Japanese subjects. METHODS: Subjects were 1796 workers, aged 18-78 years, who participated in a health survey. Dietary magnesium intake was assessed with a validated brief diet history questionnaire...
April 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29565984/severity-of-nonalcoholic-fatty-liver-disease-is-associated-with-subclinical-cerebro-cardiovascular-atherosclerosis-risk-in-korean-men
#17
Jung Eun Lee, Yong Jae Lee, Soo Yoon Chung, Hee Woo Cho, Byoung Jin Park, Dong Hyuk Jung
BACKGROUND: No studies have reported the relationship between nonalcoholic fatty liver disease (NAFLD) and concurrent cerebral artery and coronary artery atherosclerosis simultaneously. We aimed at determining whether NAFLD, as assessed by ultrasound, is associated with subclinical cerebro-cardio vascular atherosclerosis (CCVA) by multidetector-row computed tomography (MDCT), and high resolution-magnetic resonance angiography (HR-MRA). This cross-sectional study included men in the general Korean population aged 20-70 years...
2018: PloS One
https://www.readbyqxmd.com/read/29562321/the-combined-effect-of-cancer-and-cardio-metabolic-conditions-on-the-mortality-burden-in-older-adults
#18
Parminder Raina, Anne Gilsing, Heinz Freisling, Edwin van den Heuvel, Nazmul Sohel, Mazda Jenab, Pietro Ferrari, Anne Tjønneland, Vassiliki Benetou, Susan Picavet, Sture Eriksson, Ben Schöttker, Hermann Brenner, Kai-Uwe Saum, Laura Perna, Tom Wilsgaard, Antonia Trichopoulou, Paolo Boffetta, Lauren E Griffith
Background: The number of older people living with cancer and cardio-metabolic conditions is increasing but little is known about how specific combinations of these conditions impact mortality. Methods: A total of 22,692 participants aged 65 years and older from four international cohorts were followed-up for mortality for an average of 10 years (8,596 deaths). Data were harmonized across cohorts and mutually exclusive groups of disease combinations were created for cancer, MI, stroke, and diabetes at baseline...
March 19, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29559272/amino-acid-levels-in-nascent-metabolic-syndrome-a-contributor-to-the-pro-inflammatory-burden
#19
Priya Reddy, Joseph Leong, Ishwarlal Jialal
AIMS: Metabolic Syndrome (MetS) is a cluster of cardio-metabolic risk factors characterized by low-grade inflammation which confers an increased risk for type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). Prior studies have linked elevated branched chain amino acids (BCAA) and aromatic amino acids (AAA) with T2DM and CVD. Due to the paucity of data in MetS, the aim of this study was to investigate the status of amino acids as early biomarkers of nascent MetS patients without T2DM and CVD or smoking...
March 9, 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29540275/circulating-odd-chain-saturated-fatty-acids-were-associated-with-arteriosclerosis-among-patients-with-diabetes-dyslipidemia-or-hypertension-in-sri-lanka-but-not-japan
#20
Kayo Kurotani, Palitha Karunapema, Kapila Jayaratne, Masao Sato, Takuya Hayashi, Hiroshi Kajio, Shoji Fukuda, Hisao Hara, Osamu Okazaki, Achala Upendra Jayatilleke, Daisuke Nonaka, Mitsuhiko Noda, Tetsuya Mizoue
The differences in the morbidity and mortality of cardiovascular diseases between Sri Lankan and Japanese populations might be explained by the differences in their diet, especially fat. To test the hypothesis that the fatty acid (FA) compositions differ between Sri Lankan and Japanese populations and that high concentrations of n-3 polyunsaturated FAs and linoleic acid are associated with a low level of arteriosclerosis, the authors compared the circulating FA compositions between Sri Lankan and Japanese populations and examined the association of the circulating FA composition with arterial stiffness in each population...
February 2018: Nutrition Research
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