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Oxytocin

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https://www.readbyqxmd.com/read/28820340/effect-of-support-supervision-on-maternal-and-newborn-health-services-and-practices-in-rural-eastern-uganda
#1
Angela N Kisakye, Rornald Muhumuza Kananura, Elizabeth Ekirapa-Kiracho, John Bua, Martha Akulume, Gertrude Namazzi, Suzanne Namusoke Kiwanuka
BACKGROUND: Support supervision is one of the strategies used to check the quality of services provided at health facilities. From 2013 to 2015, Makerere University School of Public Health strengthened support supervision in the district of Kibuku, Kamuli and Pallisa in Eastern Uganda to improve the quality of maternal and newborn services. OBJECTIVE: This article assesses quality improvements in maternal and newborn care services and practices during this period...
August 2017: Global Health Action
https://www.readbyqxmd.com/read/28819985/prediction-of-labor-outcome-using-serial-transperineal-ultrasound-in-the-first-stage-of-labor
#2
Chung Ming Chor, Liona Chiu Yee Poon, Tak Yeung Leung
OBJECTIVE: To evaluate the feasibility of predicting labor outcome using serial transperineal ultrasound (TPU) in the early active phase of labor. METHODS: This is a single center prospective observational study in a tertiary obstetrics unit in Hong Kong. Nulliparous women carrying singleton pregnancy at the onset of active phase of labor were recruited. Serial 3D volumes by TPU were acquired and then repeated after 1 and 2 hours, which were subsequently analyzed for fetal head symphyseal distance (HSD), angle of progression (AoP) and fetal head progression distance (PD)...
August 18, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28819236/impact-of-sex-fat-distribution-and-initial-body-weight-on-oxytocin-s-body-weight-regulation
#3
Yuko Maejima, Masato Aoyama, Kazuho Sakamoto, Teruo Jojima, Yoshimasa Aso, Katsuya Takasu, Seiichi Takenosihita, Kenju Shimomura
Obesity is considered as a worldwide problem in both males and females. Although many studies have demonstrated the efficiency of oxytocin (Oxt) as an anti-obesity peptide, there is no comparative study of its effect in males and females. This study aims to determine factors (sex, initial body weight, and fat distribution) that may affect the ability of Oxt to regulate body weight (BW). With regard to sex, Oxt reduced BW similarly in males and females under both high fat diet (HFD) and standard chow-fed condition...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28818500/cryptic-sexual-dimorphism-in-spatial-memory-and-hippocampal-oxytocin-receptors-in-prairie-voles-microtus-ochrogaster
#4
Marissa A Rice, Lauren E Hobbs, Kelly J Wallace, Alexander G Ophir
Sex differences are well documented and are conventionally associated with intense sex-specific selection. For example, spatial memory is frequently better in males, presumably due to males' tendency to navigate large spaces to find mates. Alternatively, monogamy (in which sex-specific selection is relatively relaxed) should diminish or eliminate differences in spatial ability and the mechanisms associated with this behavior. Nevertheless, phenotypic differences between monogamous males and females persist, sometimes cryptically...
August 14, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28815558/sequence-variants-in-esr1-and-oxtr-are-associated-with-mayer-rokitansky-k%C3%A3-ster-hauser-syndrome
#5
Sara Yvonne Brucker, Liliane Frank, Simone Eisenbeis, Melanie Henes, Diethelm Wallwiener, Olaf Riess, Barbara Van Eijck, Dorit Schöller, Michael Bonin, Kristin Katharina Rall
INTRODUCTION: Mayer-Rokitansky-Küster-Hauser syndrome (MRKHS) is characterized by congenital absence of the uterus and the upper two-thirds of the vagina in otherwise phenotypically normal females. It is found isolated or associated with renal, skeletal and other malformations. Despite of ongoing research, the etiology is mainly unknown. For a long time, the hypothesis of deficient hormone receptors as cause for MRKHS exists, and is supported by previous findings of our group. The aim of the present study was to identify unknown genetic causes for MRKHS and to compare them with data banks including a review of the literature...
August 16, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28813252/oxytocin-a-parenting-hormone
#6
REVIEW
Ruth Feldman, Marian J Bakermans-Kranenburg
In non-human mammals mothering is hormone-dependent, with crucial roles for oxytocin and prolactin. While human parenting is not hormone-dependent, hormonal changes in oxytocin, vasopressin, prolactin, testosterone, and cortisol prime and accompany the expression of parenting. In the following we focus on oxytocin (OT) as a key hormone in human parenting. OT is a nine-amino-acid neuropeptide hormone which evolved from the ancient vasotocin molecule approximately 650 MYO. OT is implicated in sociality across vertebrate evolution and substantial research has pinpointed its role in birth, lactation, and maternal care in mammals...
June 2017: Current Opinion in Psychology
https://www.readbyqxmd.com/read/28812274/oxytocin-and-anxiety-disorders
#7
Michael G Gottschalk, Katharina Domschke
In the present chapter, we review the literature focusing on oxytocin (OT)-centered research in anxiety spectrum conditions, comprising separation anxiety disorder, specific phobias, social anxiety disorder (SAD), panic disorder, generalized anxiety disorder, and anxiety-related endophenotypes (e.g., trust behavior, behavioral inhibition, neuroticism, and state/trait anxiety). OT receptor gene (OXTR) polymorphisms have been implicated in gene-environment interactions with attachment style and childhood maltreatment and to influence clinical outcomes, including SAD intensity and limbic responsiveness...
August 16, 2017: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/28812273/a-precision-medicine-approach-to-oxytocin%C3%A2-trials
#8
Elissar Andari, Rene Hurlemann, Larry J Young
In this chapter, we introduce a new area of social pharmacology that encompasses the study of the role of neuromodulators in modulating a wide range of social behaviors and brain function, with the interplay of genetic and epigenetic factors. There are increasing evidences for the role of the neuropeptide oxytocin in modulating a wide range of social behaviors, in reducing anxiety, and in impacting the social brain network. Oxytocin also promotes social functions in patients with neuropsychiatric disorders, such as autism and reduces anxiety and fear in anxiety disorders...
August 16, 2017: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/28812272/oxytocin-and-borderline-personality-disorder
#9
Katja Bertsch, Sabine C Herpertz
Borderline personality disorder (BPD) is a prevalent and severe mental disorder with affect dysregulation, impulsivity, and interpersonal dysfunction as its core features. Up to now, six studies have been performed to investigate the role of oxytocin in the pathogenesis of BPD. While a beneficial effect of oxytocin on threat processing and stress responsiveness was found, other studies using an oxytocin challenge design presented with rather heterogeneous results. Future studies have to include a sufficiently large sample of patients, control for gender, and focus on mechanisms known to be related to aversive early life experiences...
August 16, 2017: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/28812271/oxytocin-and-interpersonal-relationships
#10
Alexandra Patin, Dirk Scheele, Rene Hurlemann
The neuropeptide oxytocin (OT) has emerged as a potent modulator of diverse aspects of interpersonal relationships. OT appears to work in close interaction with several other neurotransmitter networks, including the dopaminergic reward circuit, and to be dependent on sex-specific hormonal influences. In this chapter, we focus on four main domains of OT and interpersonal relationships, including (1) the protective effect of OT on an individual's ability to withstand stress (i.e., stress buffering), (2) the effect of OT on emotion recognition and empathy, (3) OT's ability to enhance social synchrony and cooperation among individuals, and (4) the effect of OT on an individual's perception of social touch...
August 16, 2017: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/28812270/oxytocin-and-facial-emotion-recognition
#11
Mark A Ellenbogen
The expression of emotion in faces serves numerous meaningful functions, such as conveying messages of danger or approach, facilitating communication, and promoting the formation of social bonds and relationships. The study of facial expressions of emotion has become integral to research in social psychology and social neuroscience, particularly with respect to the neuropeptide oxytocin. This chapter examines how oxytocin influences the processing of emotion in faces by reviewing intranasal administration studies of automatic processing, selective attention, and emotion recognition...
August 16, 2017: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/28812269/oxytocin-signaling-in-the-early-life-of-mammals-link-to-neurodevelopmental-disorders-associated-with-asd
#12
Françoise Muscatelli, Michel G Desarménien, Valery Matarazzo, Valery Grinevich
Oxytocin plays a role in various functions including endocrine and immune functions but also parent-infant bonding and social interactions. It might be considered as a main neuropeptide involved in mediating the regulation of adaptive interactions between an individual and his/her environment. Recently, a critical role of oxytocin in early life has been revealed in sensory processing and multi-modal integration that are essential for normal postnatal neurodevelopment. An early alteration in the oxytocin-system may disturb its maturation and may have short-term and long-term pathological consequences such as autism spectrum disorders...
August 16, 2017: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/28812268/oxytocin-and-human-evolution
#13
C Sue Carter
A small, but powerful neuropeptide, oxytocin coordinates processes that are central to both human reproduction and human evolution. Also embedded in the evolution of the human nervous system are unique pathways necessary for modern human sociality and cognition. Oxytocin is necessary for facilitating the birth process, especially in light of anatomical restrictions imposed by upright human locomotion, which depends on a fixed pelvis. Oxytocin, by facilitating birth, allowed the development of a large cortex and a protective bony cranium...
August 16, 2017: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/28812267/oxytocin-and-parental-behaviors
#14
Chihiro Yoshihara, Michael Numan, Kumi O Kuroda
The oxytocin/vasopressin ancestor molecule has been regulating reproductive and social behaviors for more than 500 million years. In all mammals, oxytocin is the hormone indispensable for milk-ejection during nursing (maternal milk provision to offspring), a process that is crucial for successful mammalian parental care. In laboratory mice, a remarkable transcriptional activation occurs during parental behavior within the anterior commissural nucleus (AC), the largest magnocellular oxytocin cell population within the medial preoptic area (although the transcriptional activation was limited to non-oxytocinergic neurons in the AC)...
August 16, 2017: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/28812266/oxytocin-and-social-relationships-from-attachment-to-bond-disruption
#15
Oliver J Bosch, Larry J Young
Social relationships throughout life are vital for well-being and physical and mental health. A significant amount of research in animal models as well as in humans suggests that oxytocin (OT) plays an important role in the development of the capacity to form social bonds, the mediation of the positive aspects of early-life nurturing on adult bonding capacity, and the maintenance of social bonding. Here, we focus on the extensive research on a socially monogamous rodent model organism, the prairie vole (Microtus ochrogaster)...
August 16, 2017: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/28812265/oxytocin-and-olfaction
#16
Lars-Lennart Oettl, Wolfgang Kelsch
Social signals are identified through processing in sensory systems to trigger appropriate behavioral responses. Social signals are received primarily in most mammals through the olfactory system. Individuals are recognized based on their unique blend of odorants. Such individual recognition is critical to distinguish familiar conspecifics from intruders and to recognize offspring. Social signals can also trigger stereotyped responses like mating behaviors. Specific sensory pathways for individual recognition and eliciting stereotyped responses have been identified both in the early olfactory system and its connected cortices...
August 16, 2017: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/28812264/oxytocin-and-steroid-actions
#17
Gustav F Jirikowski, Scott D Ochs, Jack D Caldwell
Biosynthesis and secretion of the hypothalamic nonapeptide oxytocin largely depends on steroid hormones. Estradiol, corticosterone, and vitamin D seem to be the most prominent actors. Due to their lipophilic nature, systemic steroids are thought to be capable of crossing the blood-brain barrier, thus mediating central functions including neuroendocrine and behavioral control. The actual mode of action of steroids in hypothalamic circuitry is still unknown: Most of the oxytocinergic perikarya lack nuclear steroid receptors but express proteins suspected to be membrane receptors for steroids...
August 16, 2017: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/28812263/molecular-basis-of-oxytocin-receptor-signalling-in-the-brain-what-we-know-and-what-we-need-to-know
#18
Marta Busnelli, Bice Chini
Oxytocin (OT), a hypothalamic neuropeptide involved in regulating the social behaviour of all vertebrates, has been proposed as a treatment for a number of neuropsychiatric disorders characterised by deficits in the social domain. Over the last few decades, advances focused on understanding the social effects of OT and its role in physiological conditions and brain diseases, but much less has been done to clarify the molecular cascade of events involved in mediating such effects and in particular the cellular and molecular pharmacology of OT and its target receptor (OTR) in neuronal and glial cells...
August 16, 2017: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/28808909/oxytocin-and-anxiety-disorders-translational-and-therapeutic-aspects
#19
REVIEW
Wadih Jean Naja, Michaelangelo Pietro Aoun
PURPOSE OF REVIEW: This review aims to evaluate the most recent literature examining the oxytocin (OXT) system's role in human anxiety by surveying various fields of preclinical and clinical research supporting this role, and queries whether the OXT system might be a target for novel anxiolytics. RECENT FINDINGS: Evidence from the diverse body of literature presented here, from translational research, genetic and neuroimaging studies, to clinical trials of intranasal (IN) OXT reveals a positive association...
August 15, 2017: Current Psychiatry Reports
https://www.readbyqxmd.com/read/28808030/oxytocin-enforced-norm-compliance-reduces-xenophobic-outgroup-rejection
#20
Nina Marsh, Dirk Scheele, Justin S Feinstein, Holger Gerhardt, Sabrina Strang, Wolfgang Maier, René Hurlemann
Never before have individuals had to adapt to social environments defined by such magnitudes of ethnic diversity and cultural differentiation. However, neurobiological evidence informing about strategies to reduce xenophobic sentiment and foster altruistic cooperation with outsiders is scarce. In a series of experiments settled in the context of the current refugee crisis, we tested the propensity of 183 Caucasian participants to make donations to people in need, half of whom were refugees (outgroup) and half of whom were natives (ingroup)...
August 14, 2017: Proceedings of the National Academy of Sciences of the United States of America
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