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inflammatory bowel disease chinese medicine

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https://www.readbyqxmd.com/read/28711031/the-sinomenine-enteric-coated-microspheres-suppressed-the-tlr-nf-%C3%AE%C2%BAb-signaling-in-dss-induced-experimental-colitis
#1
Huifang Xiong, Liang Tian, Zihan Zhao, Shuping Chen, Qiaoyun Zhao, Junbo Hong, Yong Xie, Nanjin Zhou, Yingjun Fu
Sinomenine is a pure alkaloid with immunosuppressive effects that is extracted from the Chinese medicinal plant Sinomenium acutum. We studied the therapeutic effects of sinomenine on inflammatory bowel disease. In this study, we randomly divided mice into the following ten groups: Control group; DSS-induced colitis group; Salicylazosulfapyridine (SASP)-treated group; Chitosan-treated group; low-, medium-, and high-dose sinomenine-treated and sinomenine enteric-coated microspheres-treated groups. We recorded changes in colon length, disease activity index (DAI), and colon pathology, measured TLR4, MyD88, SIGIRR, NF-κB p65 protein levels and inflammatory serum cytokine levels...
July 12, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28690663/huangqin-tang-and-ingredients-in-modulating-the-pathogenesis-of-ulcerative-colitis
#2
REVIEW
Chunyan Wang, Xudong Tang, Li Zhang
Ulcerative colitis (UC) is the most common inflammatory bowel disease worldwide. Current therapies in UC cause limitations, and herb medicine provides an important choice for UC treatment. Huangqin-Tang (HQT) is a well-known classical traditional Chinese herbal formula and has been used in China for thousands of years. A large number of pharmacological studies demonstrated HQT and its ingredients to be effective in treating UC. Though the therapeutic effect has been evaluated, comprehensive up-to-date reviews in this field are not yet available...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28664158/celastrol-a-spectrum-of-treatment-opportunities-in-chronic-diseases
#3
REVIEW
Rita Cascão, João E Fonseca, Luis F Moita
The identification of new bioactive compounds derived from medicinal plants with significant therapeutic properties has attracted considerable interest in recent years. Such is the case of the Tripterygium wilfordii (TW), an herb used in Chinese medicine. Clinical trials performed so far using its root extracts have shown impressive therapeutic properties but also revealed substantial gastrointestinal side effects. The most promising bioactive compound obtained from TW is celastrol. During the last decade, an increasing number of studies were published highlighting the medicinal usefulness of celastrol in diverse clinical areas...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28652704/rhein-attenuates-inflammation-through-inhibition-of-nf-%C3%AE%C2%BAb-and-nalp3-inflammasome-in-vivo-and-in-vitro
#4
Hui Ge, Hao Tang, Yanbing Liang, Jingguo Wu, Qing Yang, Lijin Zeng, Zhongfu Ma
Rhein is an important component in traditional Chinese herbal medicine formulations for gastrointestinal disorders, including inflammatory bowel diseases such as ulcerative colitis. In this study, we investigated the beneficial effects of rhein in inflammation models in the transgenic zebrafish line TG (corolla eGFP), in which both macrophages and neutrophils express eGFP and RAW264.7 macrophages. We found that the tail-cutting-induced migration of immune cells was significantly reduced in transgenic zebrafish treated with rhein...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28619075/anti-inflammatory-effect-of-chang-an-shuan-on-tnbs-induced-experimental-colitis-in-rats
#5
Hong Mi, Feng-Bin Liu, Hai-Wen Li, Jiang-Tao Hou, Pei-Wu Li
BACKGROUND: Inflammatory bowel disease (IBD), denominated by Crohn's disease and ulcerative colitis, is often associated with abdominal pain, diarrhea and bloody stool. The standard protocols for treating colitis conditions are not satisfactory; thus, complementary and alternative medicines have been increasingly accepted by IBD sufferers worldwide. In this study, we aimed to elucidate the anti-inflammatory effect of Chang-An-Shuan (CAS), a 6-herb Chinese medicinal formula, on 2, 4, 6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in rats and the underlying mechanisms...
June 15, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28451385/a-network-pharmacology-approach-to-establish-the-pharmacological-mechanism-of-jiaweixianjitang-on-inflammatory-bowel-disease
#6
Ling-Jia Tao, Wen-Ting Chen, Lin Jing, Qing Ji, Jian-Lin Ren
The aim of the present study was to characterize the molecular mechanism of the effective components of JiaWeiXianJiTang (JWXJT), a traditional Chinese medicine, on inflammatory bowel disease (IBD) using network pharmacology technology. Data regarding natural molecules of JWXJT, targets of IBD, and interactions between natural molecules and IBD targets were screened. Network pharmacology of the interactions between natural molecules and IBD targets were drawn using Cytoscape v3.2.1. As a result of screening, 205 interactions were identified between 673 natural molecules and 76 targets of IBD...
March 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28278495/antioxidant-supplements-and-gastrointestinal-diseases-a-critical-appraisal
#7
Islam Khan, Sue E Samson, Ashok Kumar Grover
The gastrointestinal tract digests and absorbs dietary nutrients, protects the body against physical and chemical damage from contents in its lumen, provides immunity against external antigens, and keeps an optimum environment for the gut microbiota. These functions cannot be performed normally in several diseases of which the following are discussed here: irritable bowel syndrome and inflammatory bowel disease, which includes Crohn's disease and ulcerative colitis. Because these diseases are associated with oxidative stress, a host of antioxidant supplements are used for maintenance and recovery of the gut functions...
2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/28049460/bitter-melon-protects-against-er-stress-in-ls174t-colonic-epithelial-cells
#8
Dale A Kunde, Wai Chin Chong, Prathiba V Nerurkar, Kiran D K Ahuja, Jeremy Just, Jason A Smith, Nuri Guven, Rajaraman D Eri
BACKGROUND: Bitter Melon (BM) has been used as a functional food in traditional Chinese and Indian medicine for many generations and has gained a great deal of attention due to its apparent benefits in moderating some of the pathogenic processes in a variety of inflammatory conditions. BM extract (BME) has been shown to possess strong anti-oxidant properties. In addition, it can ameliorate oxidative stress and potentially ER stress. There is increasing evidence that oxidative and ER stress are major contributors for intestinal secretory cell dysfunction which leads to local inflammation and disease pathogenesis that are hallmarks of inflammatory bowel diseases (IBD)...
January 3, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27982094/huangqin-tang-ameliorates-dextran-sodium-sulphate-induced-colitis-by-regulating-intestinal-epithelial-cell-homeostasis-inflammation-and-immune-response
#9
Ying Zou, Jiantao Lin, Wenyang Li, Zhuguo Wu, Zhiwei He, Guoliang Huang, Jian Wang, Caiguo Ye, Xiaoyan Cheng, Congcong Ding, Xuebao Zheng, Honggang Chi
Huangqin-tang (HQT) is a traditional Chinese medicine (TCM) formula widely used for the treatment of inflammatory bowel disease in China. However, the molecular mechanisms by which HQT protects the colon are unclear. We studied the protective effects of HQT and the underlying mechanisms in an experimental mouse model and in vitro. In vivo, dextran sodium sulphate (DSS)-induced acute and chronic colitis were significantly ameliorated by HQT as gauged by phenotypic, histopathologic and inflammatory manifestations of the disease...
December 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27879679/hydrostatin-tl1-an-anti-inflammatory-active-peptide-from-the-venom-gland-of-hydrophis-cyanocinctus-in-the-south-china-sea
#10
Ningyuan Wang, Yan Huang, An Li, Hailong Jiang, Jie Wang, Jianzhong Li, Lei Qiu, Ka Li, Yiming Lu
Tumor necrosis factor (TNF)-α is a pleiotropic cytokine with intense pro-inflammatory and immunomodulatory properties, and anti-TNF-α biologics are effective therapies for various inflammatory diseases such as inflammatory bowel disease (IBD) and sepsis. Snake venom, as a traditional Chinese medicine, has been used in the treatment of inflammatory diseases in China for centuries. In this research, we constructed a venom gland T7 phage display library of the sea snake Hydrophis cyanocinctus to screen bioactive compounds that antagonize TNF-α and identified a novel nine-amino-acid peptide, termed hydrostatin-TL1 (H-TL1)...
November 22, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27671821/celastrol-and-its-role-in-controlling%C3%A2-chronic-diseases
#11
Shivaprasad H Venkatesha, Kamal D Moudgil
Celastrol, a triterpenoid derived from traditional Chinese medicinal plants, has anti-inflammatory, antioxidant, and anticancer activities. Celastrol has shown preventive/therapeutic effects in experimental models of several chronic diseases. These include, chronic inflammatory and autoimmune diseases (e.g., rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, inflammatory bowel disease, and psoriasis), neurodegenerative disorders (e.g., Alzheimer's disease, Parkinson's disease, and Amyotrophic lateral sclerosis), atherosclerosis, obesity, Type 2 diabetes, and cancer...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27452656/zhikang-capsule-ameliorates-dextran-sodium-sulfate-induced-colitis-by-inhibition-of-inflammation-apoptosis-oxidative-stress-and-myd88-dependent-tlr4-signaling-pathway
#12
Liang Fei, Keshu Xu
ETHNOPHARMACOLOGICAL RELEVANCE: Zhikang Capsule (ZKC) is a traditional Chinese medicine (TCM) modified from classic formulas Qi-Li-San (an ancient formula dating to Qing Dynasty) and Fu-Jin-Sheng-Ji-San (written into The Golden Mirror of Medicine). ZKC contains 14 kinds of materials and has been widely used for the clinical therapy of inflammatory bowel diseases (IBD) for a long time. However, the therapeutic mechanisms of ZKC are still unclear. AIM OF THE STUDY: To determine the protective effect of ZKC on dextran sodium sulfate (DSS)-induced colitis and explore the underlying mechanisms...
November 4, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27280937/astagalus-polysaccharide-attenuates-murine-colitis-through-inhibiton-of-the-nlrp3-inflammasome
#13
Zhiqiang Tian, Yao Liu, Bo Yang, Ji Zhang, Haiyang He, Hui Ge, Yuzhang Wu, Zigang Shen
Astragalus polysaccharide is an important bioactive component of Astragalus membranaceus, an herb used in traditional Chinese medicine for treating inflammatory bowel disease. The NOD-like receptor protein 3 inflammasome plays an important role in the pathogenesis of inflammatory bowel disease. However, little is known about the role of NOD-like receptor protein 3 inflammasome in Astragalus polysaccharide-treated mice with experimental colitis. For this study, we investigated the molecular mechanisms that underlie the treatment of inflammatory bowel disease by Astragalus polysaccharide...
January 2017: Planta Medica
https://www.readbyqxmd.com/read/27158082/screening-of-an-anti-inflammatory-peptide-from-hydrophis-cyanocinctus-and-analysis-of-its-activities-and-mechanism-in-dss-induced-acute-colitis
#14
Zengjie Zheng, Hailong Jiang, Yan Huang, Jie Wang, Lei Qiu, Zhenlin Hu, Xingyuan Ma, Yiming Lu
Snake has been used for centuries as a traditional Chinese medicine, especially for therapeutic treatment for inflammatory diseases; however, its mechanisms of action and active constituents remain controversial. In our study, a tumor necrosis factor receptor 1 (TNFR1) selective binding peptide, Hydrostatin-SN1 (H-SN1), which was screened from a Hydrophis cyanocinctus venom gland T7 phage display library, was shown to exhibit significant anti-inflammatory activity in vitro and in vivo. As a TNFR1 antagonist, it reduced cytotoxicity mediated by TNF-α in L929 fibroblasts and effectively inhibited the combination between TNF-α with TNFR1 in surface plasmon resonance analysis...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27111831/non-surgical-interventions-for-late-rectal-problems-proctopathy-of-radiotherapy-in-people-who-have-received-radiotherapy-to-the-pelvis
#15
REVIEW
Fleur T van de Wetering, Leen Verleye, H Jervoise N Andreyev, Jane Maher, Joan Vlayen, Bradley R Pieters, Geertjan van Tienhoven, Rob J P M Scholten
BACKGROUND: This is an update of a Cochrane review first published in 2002, and previously updated in 2007. Late radiation rectal problems (proctopathy) include bleeding, pain, faecal urgency, and incontinence and may develop after pelvic radiotherapy treatment for cancer. OBJECTIVES: To assess the effectiveness and safety of non-surgical interventions for managing late radiation proctopathy. SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (Issue 11, 2015); MEDLINE (Ovid); EMBASE (Ovid); CANCERCD; Science Citation Index; and CINAHL from inception to November 2015...
April 25, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27107073/therapeutic-efficacy-of-the-traditional-chinese-medicine-baishaoqiwu-on-tnbs-induced-colitis-is-associated-with-down-regulation-of-the-tlr4-myd88-nf-%C3%AE%C2%BAb-signaling-pathway
#16
Xiaoping Xu, Lei Zhang, Zhaohui Liu, Yuan Pan, Dong Chen, Zhouyu Yang, Qun Deng, Xinghua Cao, Y U Sun, Zhijian Yang, Robert M Hoffman, Hong Yuan
BACKGROUND/AIM: The traditional Chinese medicine Baishaoqiwu (BSQW) has been previously used to clinically treat inflammatory bowel diseases. However, the mechanisms of it's therapeutic efficacy remain unclear. The aim of this study was to examine the efficacy of BSQW on ulcerative colitis (UC) and the TLR4/MyD88/NF-κB signaling pathway in a rat model of colitis. MATERIALS AND METHODS: The colitis rat model was induced by anal instillation of 2,4,6-trinitrobenzene sulfonic acid (TNBS)...
May 2016: In Vivo
https://www.readbyqxmd.com/read/26492645/suppression-of-mapk-and-nf-%C3%AE%C2%BA-b-pathways-by-schisandrin-b-contributes-to-attenuation-of-dss-induced-mice-model-of-inflammatory-bowel-disease
#17
Weidong Liu, Yang Liu, Zhi Wang, Ting Yu, Qin Lu, Hong Chen
Schisandrin B (Sch B), the most abundant dibenzocyclooctadiene lignan isolated from the traditional Chinese medicinal herb Schisandra chinensis (Turcz.) Baill, possesses various biological activities, such as hepatic protection, anti-tumor, anti-inflammatory and anti-cardiovascular properties. However, the effect of Sch B on inflammatory bowel disease (IBD) is not yet known. The aim of this study was to investigate whether Sch B has protective effect against dextran sulfate sodium (DSS)-induced colitis in a mouse model...
September 2015: Die Pharmazie
https://www.readbyqxmd.com/read/26043563/-effect-of-baicalin-on-signal-transduction-and-activating-transcription-factor-expression-in-ulcerative-colitis-patients
#18
Feng-yan Yu, Shao-gang Huang, Hai-yan Zhang, Hong-gang Chi, Ying Zou, Ru-xi Lu, Xue-bao Zheng
OBJECTIVE: To explore the intervention of baicalin on signal transduction and activating transcription factor expression of ulcerative colitis (UC) patients. METHODS: Recruited were UC patients at Outpatient Department of Digestive Disease, Inpatient Department of Digestive Disease, Center for Digestive Endoscopy of College City Branch, Guangdong Provincial Hospital of Traditional Chinese Medicine, and Southern Hospital affiliated to Southern Medical University from June 2010 to January 2011...
April 2015: Chinese Journal of Integrated Traditional and Western Medicine
https://www.readbyqxmd.com/read/25554639/a-chinese-medicinal-formulation-ameliorates-dextran-sulfate-sodium-induced-experimental-colitis-by-suppressing-the-activity-of-nuclear-factor-kappab-signaling
#19
Siu Wai Tsang, Siu Po Ip, Justin Che-Yuen Wu, Siew-Chien Ng, Ken Kin-Lam Yung, Zhao-Xiang Bian
ETHNOPHARMACOLOGICAL RELEVANCE: Inflammatory bowel disease (IBD) is generally associated with a set of debilitating symptoms including abdominal pain, tenesmus, diarrhea and bloody stool. The standard approaches for treating IBD, which are the application of pharmaceuticals, are often unsatisfactory. IBD patients may suffer from repeated relapses and even exacerbation after taking these medications. Thus, patients are increasingly seeking relief through the use of complementary and alternative medicines...
March 13, 2015: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/25505015/faecal-microbiota-transplantation
#20
REVIEW
(no author information available yet)
The use of faeces for the treatment of gastrointestinal diseases was described in 4th century Chinese medicine for the treatment of severe diarrhoea.1 More recently there has been renewed interest in this unconventional biological therapy, particularly for the treatment of recurrent Clostridium difficile infection (CDI) and to a lesser extent inflammatory bowel diseases (IBD). Faecal microbiota transplantation† (FMT) involves the introduction of enteric bacteria from the faeces of healthy donors in order to restore a healthy balance of bacteria in the gut...
December 2014: Drug and Therapeutics Bulletin
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