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raclopride AND "positron emission tomography"

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https://www.readbyqxmd.com/read/28507321/pet-imaging-of-dopamine-d2-receptor-internalization-in-schizophrenia
#1
J J Weinstein, E van de Giessen, R J Rosengard, X Xu, N Ojeil, G Brucato, R B Gil, L S Kegeles, M Laruelle, M Slifstein, A Abi-Dargham
Recent genetic, molecular and post-mortem studies suggest impaired dopamine (DA)-D2 receptor (D2R) trafficking in patients with schizophrenia (SZ). Imaging and preclinical studies have shown agonist-induced D2R internalization can be imaged with positron emission tomography (PET) using D2R radiotracers combined with psychostimulant challenge. This is feasible if radiotracer binding is measured when postchallenge DA levels have returned to baseline, following the initial competition phase between DA and radiotracer for binding to D2R...
May 16, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28493519/neurotransmitters-behind-pain-relief-with-transcranial-magnetic-stimulation-positron-emission-tomography-evidence-for-release-of-endogenous-opioids
#2
S Lamusuo, J Hirvonen, P Lindholm, I K Martikainen, N Hagelberg, R Parkkola, T Taiminen, J Hietala, S Helin, A Virtanen, A Pertovaara, S K Jääskeläinen
BACKGROUND: Repetitive transcranial magnetic stimulation (rTMS) at M1/S1 cortex has been shown to alleviate neuropathic pain. OBJECTIVES: To investigate the possible neurobiological correlates of cortical neurostimulation for the pain relief. METHODS: We studied the effects of M1/S1 rTMS on nociception, brain dopamine D2 and μ-opioid receptors using a randomized, sham-controlled, double-blinded crossover study design and 3D-positron emission tomography (PET)...
May 11, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28440810/naltrexone-modulates-dopamine-release-following-chronic-but-not-acute-amphetamine-administration-a-translational-study
#3
N Jayaram-Lindström, J Guterstam, J Häggkvist, M Ericson, T Malmlöf, B Schilström, C Halldin, S Cervenka, T Saijo, A-L Nordström, J Franck
The opioid antagonist naltrexone has been shown to attenuate the subjective effects of amphetamine. However, the mechanisms behind this modulatory effect are currently unknown. We hypothesized that naltrexone would diminish the striatal dopamine release induced by amphetamine, which is considered an important mechanism behind many of its stimulant properties. We used positron emission tomography and the dopamine D2-receptor radioligand [(11)C]raclopride in healthy subjects to study the dopaminergic effects of an amphetamine injection after pretreatment with naltrexone or placebo...
April 25, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28356473/density-of-available-striatal-dopamine-receptors-predicts-trait-impulsiveness-during-performance-of-an-attention-demanding-task
#4
Brian A Anderson, Hiroto Kuwabara, Dean F Wong, Susan M Courtney
The density (measured at binding potential) of available striatal D2/D3 receptors has been shown to predict trait impulsiveness. This relationship is highly robust and well replicated. In each case, however, the availability of dopamine receptors was measured at rest. More broadly, the extent to which relationships between dopamine receptor availability and behavioral traits holds when participants perform a cognitive task is unclear. Furthermore, the performance of a cognitive task engages fundamentally different neural networks than are maximally engaged during the resting state...
March 29, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28350401/systemic-inflammation-enhances-stimulant-induced-striatal-dopamine-elevation
#5
J R Petrulli, B Kalish, N B Nabulsi, Y Huang, J Hannestad, E D Morris
Changes in the mesolimbic dopamine (DA) system are implicated in a range of neuropsychiatric conditions including addiction, depression and schizophrenia. Dysfunction of the neuroimmune system is often comorbid with such conditions and affects similar areas of the brain. The goal of this study was to use positron emission tomography with the dopamine D2 antagonist tracer, (11)C-raclopride, to explore the effect of acute immune activation on striatal DA levels. DA transmission was modulated by an oral methylphenidate (MP) challenge in order to reliably elicit DA elevation...
March 28, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28346539/is-there-a-relation-between-novelty-seeking-striatal-dopamine-release-and-frontal-cortical-thickness
#6
Natalia Jaworska, Sylvia M Cox, Kevin F Casey, Isabelle Boileau, Mariya Cherkasova, Kevin Larcher, Alain Dagher, Chawki Benkelfat, Marco Leyton
BACKGROUND: Novelty-seeking (NS) and impulsive personality traits have been proposed to reflect an interplay between fronto-cortical and limbic systems, including the limbic striatum (LS). Although neuroimaging studies have provided some evidence for this, most are comprised of small samples and many report surprisingly large effects given the challenges of trying to relate a snapshot of brain function or structure to an entity as complex as personality. The current work tested a priori hypotheses about associations between striatal dopamine (DA) release, cortical thickness (CT), and NS in a large sample of healthy adults...
2017: PloS One
https://www.readbyqxmd.com/read/28254508/patterns-of-age-related-changes-for-phosphodiesterase-type-10a-in-comparison-with-dopamine-d2-3-receptors-and-sub-cortical-volumes-in-the-human-basal-ganglia-a-pet-study-with-18-f-mni-659-and-11-c-raclopride-with-correction-for-partial-volume-effect
#7
Patrik Fazio, Martin Schain, Ladislav Mrzljak, Nahid Amini, Sangram Nag, Nabil Al-Tawil, Cheryl J Fitzer-Attas, Juliana Bronzova, Bernhard Landwehrmeyer, Cristina Sampaio, Christer Halldin, Andrea Varrone
Phosphodiesterase 10A enzyme (PDE10A) is an important striatal target that has been shown to be affected in patients with neurodegenerative disorders, particularly Huntington´s disease (HD). PDE10A is expressed on striatal neurones in basal ganglia where other known molecular targets are enriched such as dopamine D2/3 receptors (D2/3 R). The aim of this study was to examine the availability of PDE10A enzyme in relation with age and gender and to compare those changes with those related to D2/3 R and volumes in different regions of the basal ganglia...
February 28, 2017: NeuroImage
https://www.readbyqxmd.com/read/28239334/micropet-outperforms-beta-microprobes-in-determining-neuroreceptor-availability-under-pharmacological-restriction-for-cold-mass-occupancy
#8
Dorien Glorie, Stijn Servaes, Jeroen Verhaeghe, Tine Wyckhuys, Leonie Wyffels, Olivier Vanderveken, Sigrid Stroobants, Steven Staelens
Both non-invasive micro-positron emission tomography (μPET) and in situ beta-microprobes have the ability to determine radiotracer kinetics and neuroreceptor availability in vivo. Beta-microprobes were proposed as a cost-effective alternative to μPET, but literature revealed conflicting results most likely due to methodological differences and inflicted tissue damage. The current study has three main objectives: (i) evaluate the theoretical advantages of beta-microprobes; (ii) perform μPET imaging to assess the impact of (beta-micro)probe implantation on relative tracer delivery (R1) and receptor occupancy (non-displaceable binding potential, BPND) in the rat brain; and (iii) investigate whether beta-microprobe recordings produce robust results when a pharmacological restriction for cold mass dose (tracer dose condition) is imposed...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28113619/direct-parametric-reconstruction-with-joint-motion-estimation-correction-for-dynamic-brain-pet-data
#9
Jieqing Jiao, Alexandre Bousse, Kris Thielemans, Ninon Burgos, Philip Weston, Pawel Markiewicz, Jonathan Schott, David Atkinson, Simon Arridge, Brian Hutton, Sebastien Ourselin
Direct reconstruction of parametric images from raw photon counts has been shown to improve the quantitative analysis of dynamic positron emission tomography (PET) data. However it suffers from subject motion which is inevitable during the typical acquisition time of 1-2 hours. In this work we propose a framework to jointly estimate subject head motion and reconstruct the motion-corrected parametric images directly from raw PET data, so that the effects of distorted tissue-to-voxel mapping due to subject motion can be reduced in reconstructing the parametric images with motion-compensated attenuation correction and spatially aligned temporal PET data...
August 24, 2016: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/27981179/striatal-dopamine-d2-3-receptor-regulation-by-stress-inoculation-in-squirrel-monkeys
#10
Alex G Lee, Jordan M Nechvatal, Bin Shen, Christine L Buckmaster, Michael J Levy, Frederick T Chin, Alan F Schatzberg, David M Lyons
Intermittent mildly stressful situations provide opportunities to learn, practice, and improve coping in a process called stress inoculation. Stress inoculation also enhances cognitive control and response inhibition of impulsive motivated behavior. Cognitive control and motivation have been linked to striatal dopamine D2 and/or D3 receptors (DRD2/3) in rodents, monkeys, and humans. Here, we study squirrel monkeys randomized early in life to stress inoculation with or without maternal companionship and a no-stress control treatment condition...
June 2016: Neurobiology of Stress
https://www.readbyqxmd.com/read/27856625/longitudinal-small-animal-pet-imaging-of-the-zq175-mouse-model-of-huntington-disease-shows-in-vivo-changes-of-molecular-targets-in-the-striatum-and-cerebral-cortex
#11
Jenny Häggkvist, Miklós Tóth, Lenke Tari, Katarina Varnäs, Marie Svedberg, Anton Forsberg, Sangram Nag, Celia Dominguez, Ignacio Munoz-Sanjuan, Jonathan Bard, John Wityak, Andrea Varrone, Christer Halldin, Ladislav Mrzljak
Since the discovery of the HTT gene in 1993, numerous animal models have been developed to study the progression of Huntington disease (HD) and to evaluate potential new therapeutics. In the present study, we used small-animal PET to characterize the expression of molecular targets in the recently reported HD animal model, the zQ175 mouse model. Methods: Male heterozygous zQ175 (Htt(tm1Mfc)/190JChdi, CHDI-81003003) and wild-type (WT, C57BL/6J) animals were imaged with the dopamine D2 receptor radioligand (11)C-raclopride, the PDE10A radioligand (18)F-MNI-659, the dopamine D1 receptor radioligand (11)C-NNC 112, and the 5-HT2A radioligand (11)C-MDL 100907 at 6 and 9 mo of age...
April 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27766370/measurement-of-psychological-state-changes-at-low-dopamine-transporter-occupancy-following-a-clinical-dose-of-mazindol
#12
Y Kimura, J Maeda, M Yamada, K Takahata, K Yokokawa, Y Ikoma, C Seki, H Ito, M Higuchi, T Suhara
RATIONALE: The beneficial effects of psychostimulant drugs in the treatment of psychiatric disorders occur because they increase the extracellular dopamine concentration by inhibiting re-uptake of extracellular dopamine at dopamine transporters. However, the psychological effects at low dopamine transporter occupancy have not been well demonstrated. OBJECTIVES: The purpose of the study was to evaluate the psychological effects, dopamine transporter occupancy, and dopamine release induced by a single oral administration of a clinical dose of mazindol...
October 20, 2016: Psychopharmacology
https://www.readbyqxmd.com/read/27751503/the-role-of-dopamine-in-positive-and-negative-prediction-error-utilization-during-incidental-learning-insights-from-positron-emission-tomography-parkinson-s-disease-and-huntington-s-disease
#13
David Mathar, Leonora Wilkinson, Anna K Holl, Jane Neumann, Lorenz Deserno, Arno Villringer, Marjan Jahanshahi, Annette Horstmann
Incidental learning of appropriate stimulus-response associations is crucial for optimal functioning within our complex environment. Positive and negative prediction errors (PEs) serve as neural teaching signals within distinct ('direct'/'indirect') dopaminergic pathways to update associations and optimize subsequent behavior. Using a computational reinforcement learning model, we assessed learning from positive and negative PEs on a probabilistic task (Weather Prediction Task - WPT) in three populations that allow different inferences on the role of dopamine (DA) signals: (1) Healthy volunteers that repeatedly underwent [(11)C]raclopride Positron Emission Tomography (PET), allowing for assessment of striatal DA release during learning, (2) Parkinson's disease (PD) patients tested both on and off L-DOPA medication, (3) early Huntington's disease (HD) patients, a disease that is associated with hyper-activation of the 'direct' pathway...
September 19, 2016: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/27576243/direct-parametric-reconstruction-with-joint-motion-estimation-correction-for-dynamic-brain-pet-data
#14
Jieqing Jiao, Alexandre Bousse, Kris Thielemans, Ninon Burgos, Philip S J Weston, Jonathan M Schott, David Atkinson, Simon R Arridge, Brian F Hutton, Pawel Markiewicz, Sebastien Ourselin
Direct reconstruction of parametric images from raw photon counts has been shown to improve the quantitative analysis of dynamic positron emission tomography (PET) data. However it suffers from subject motion which is inevitable during the typical acquisition time of 1-2 hours. In this work we propose a framework to jointly estimate subject head motion and reconstruct the motion-corrected parametric images directly from raw PET data, so that the effects of distorted tissue-to-voxel mapping due to subject motion can be reduced in reconstructing the parametric images with motion-compensated attenuation correction and spatially aligned temporal PET data...
January 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/27557949/lack-of-association-between-dopaminergic-antagonism-and-negative-symptoms-in-schizophrenia-a-positron-emission-tomography-dopamine-d2-3-receptor-occupancy-study
#15
Gagan Fervaha, Fernando Caravaggio, David C Mamo, Benoit H Mulsant, Bruce G Pollock, Shinichiro Nakajima, Philip Gerretsen, Tarek K Rajji, Wanna Mar, Yusuke Iwata, Eric Plitman, Jun Ku Chung, Gary Remington, Ariel Graff-Guerrero
RATIONALE: Several pre-clinical studies suggest that antipsychotic medications cause secondary negative symptoms. However, direct evidence for a relationship among antipsychotic medications, their direct effects on neurotransmitter systems, and negative symptoms in schizophrenia remains controversial. OBJECTIVE: The objective of this study was to examine the relationship between antipsychotic-related dopamine D2/3 receptor occupancy and negative symptoms in patients with schizophrenia...
October 2016: Psychopharmacology
https://www.readbyqxmd.com/read/27467186/negative-association-of-pretreatment-cigarette-use-with-smoking-induced-striatal-dopamine-release-in-smokers-receiving-bupropion-treatment
#16
Aviv Malkiel Weinstein, Nanette Freedman, Joel Greif, Zipi Yemini, Eyal Mishani, Edythe London, Roland Chisin, Moshe Bocher
BACKGROUND AND OBJECTIVES: In an effort to help identify factors that maintain heavy smoking, this study tested the association of pretreatment cigarette use (cigarettes per day) with striatal dopamine release during smoking-cessation treatment. METHODS: Thirteen regular smokers (≥10 cigarettes per day) were evaluated on parameters of smoking behavior, and they entered a smoking cessation treatment protocol, including bupropion administration and individual counseling for 2 months...
September 2016: American Journal on Addictions
https://www.readbyqxmd.com/read/27459715/corticostriatal-and-dopaminergic-response-to-beer-flavor-with-both-fmri-and-11-c-raclopride-positron-emission-tomography
#17
Brandon G Oberlin, Mario Dzemidzic, Jaroslaw Harezlak, Maria A Kudela, Stella M Tran, Christina M Soeurt, Karmen K Yoder, David A Kareken
BACKGROUND: Cue-evoked drug-seeking behavior likely depends on interactions between frontal activity and ventral striatal (VST) dopamine (DA) transmission. Using [(11) C]raclopride (RAC) positron emission tomography (PET), we previously demonstrated that beer flavor (absent intoxication) elicited VST DA release in beer drinkers, inferred by RAC displacement. Here, a subset of subjects from this previous RAC-PET study underwent a similar paradigm during functional magnetic resonance imaging (fMRI) to test how orbitofrontal cortex (OFC) and VST blood oxygenation level-dependent (BOLD) responses to beer flavor are related to VST DA release and motivation to drink...
September 2016: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/27244237/association-between-striatal-dopamine-d2-d3-receptors-and-brain-activation-during-visual-attention-effects-of-sleep-deprivation
#18
D Tomasi, G-J Wang, N D Volkow
Sleep deprivation (SD) disrupts dopamine (DA) signaling and impairs attention. However, the interpretation of these concomitant effects requires a better understanding of dopamine's role in attention processing. Here we test the hypotheses that D2/D3 receptors (D2/D3R) in dorsal and ventral striatum would distinctly regulate the activation of attention regions and that, by decreasing D2/D3, SD would disrupt these associations. We measured striatal D2/D3R using positron emission tomography with [(11)C]raclopride and brain activation to a visual attention (VA) task using 4-Tesla functional magnetic resonance imaging...
2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27140603/extensive-graft-derived-dopaminergic-innervation-is-maintained-24-years-after-transplantation-in-the-degenerating-parkinsonian-brain
#19
COMMENT
Wen Li, Elisabet Englund, Håkan Widner, Bengt Mattsson, Danielle van Westen, Jimmy Lätt, Stig Rehncrona, Patrik Brundin, Anders Björklund, Olle Lindvall, Jia-Yi Li
Clinical trials using cells derived from embryonic ventral mesencephalon have shown that transplanted dopaminergic neurons can survive and function in the long term, as demonstrated by in vivo brain imaging using (18)F-fluorodopa and (11)C-raclopride positron emission tomography. Here we report the postmortem analysis of a patient with Parkinson's disease who 24 y earlier underwent unilateral transplantation of embryonic dopaminergic neurons in the putamen and subsequently exhibited major motor improvement and recovery of striatal dopaminergic function...
June 7, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27091456/reduction-of-dopamine-d2-3-receptor-binding-in-the-striatum-after-a-single-administration-of-esketamine-but-not-r-ketamine-a-pet-study-in-conscious-monkeys
#20
Kenji Hashimoto, Takeharu Kakiuchi, Hiroyuki Ohba, Shingo Nishiyama, Hideo Tsukada
R-ketamine appears to be a potent, long-lasting and safer antidepressant, relative to esketamine (S-ketamine), since it might be free of psychotomimetic side effects. Using [(11)C]raclopride and positron emission tomography (PET), we investigated whether esketamine and R-ketamine can affect dopamine D2/3 receptor binding in the conscious monkey brain. A single infusion of esketamine (0.5 mg/kg), but not R-ketamine (0.5 mg/kg), caused a reduction of binding availability of dopamine D2/3 receptor in the monkey striatum...
March 2017: European Archives of Psychiatry and Clinical Neuroscience
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