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raclopride AND "positron emission tomography"

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https://www.readbyqxmd.com/read/27856625/longitudinal-micropet-imaging-of-the-zq175-mouse-model-of-huntington-s-disease-shows-in-vivo-changes-of-molecular-targets-in-the-striatum-and-the-cerebral-cortex
#1
Jenny Häggkvist, Miklós Tóth, Lenke Tari, Katarina Varnäs, Marie Svedberg, Anton Forsberg, Sangram Nag, Celia Dominguez, Ignacio Munoz-Sanjuan, Jonathan Bard, John Wityak, Andrea Varrone, Christer Halldin, Ladislav Mrzljak
RATIONALE: Since the discovery of the HTT gene in 1993, numerous animal models have been developed to study the progression of Huntington's disease, as well as to evaluate potential new therapeutics. In the present study we used small animal positron emission tomography (PET) to characterize the expression of molecular targets in the recently reported HD animal model, the zQ175 mouse model. METHODS: Male heterozygous zQ175 (Htttm1Mfc/190JChdi, CHDI-81003003) and wild type (WT, C57BL/6J) animals were imaged with the dopamine D2-receptor radioligand [(11)C]raclopride, the PDE10A radioligand [(18)F]MNI-659, the dopamine D1-receptor radioligand [(11)C]NNC 112 and the 5-HT2A radioligand [(11)C]MDL 100907 at 6 and 9 months of age...
November 10, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27766370/measurement-of-psychological-state-changes-at-low-dopamine-transporter-occupancy-following-a-clinical-dose-of-mazindol
#2
Y Kimura, J Maeda, M Yamada, K Takahata, K Yokokawa, Y Ikoma, C Seki, H Ito, M Higuchi, T Suhara
RATIONALE: The beneficial effects of psychostimulant drugs in the treatment of psychiatric disorders occur because they increase the extracellular dopamine concentration by inhibiting re-uptake of extracellular dopamine at dopamine transporters. However, the psychological effects at low dopamine transporter occupancy have not been well demonstrated. OBJECTIVES: The purpose of the study was to evaluate the psychological effects, dopamine transporter occupancy, and dopamine release induced by a single oral administration of a clinical dose of mazindol...
October 20, 2016: Psychopharmacology
https://www.readbyqxmd.com/read/27751503/the-role-of-dopamine-in-positive-and-negative-prediction-error-utilization-during-incidental-learning-insights-from-positron-emission-tomography-parkinson-s-disease-and-huntington-s-disease
#3
David Mathar, Leonora Wilkinson, Anna K Holl, Jane Neumann, Lorenz Deserno, Arno Villringer, Marjan Jahanshahi, Annette Horstmann
Incidental learning of appropriate stimulus-response associations is crucial for optimal functioning within our complex environment. Positive and negative prediction errors (PEs) serve as neural teaching signals within distinct ('direct'/'indirect') dopaminergic pathways to update associations and optimize subsequent behavior. Using a computational reinforcement learning model, we assessed learning from positive and negative PEs on a probabilistic task (Weather Prediction Task - WPT) in three populations that allow different inferences on the role of dopamine (DA) signals: (1) Healthy volunteers that repeatedly underwent [(11)C]raclopride Positron Emission Tomography (PET), allowing for assessment of striatal DA release during learning, (2) Parkinson's disease (PD) patients tested both on and off L-DOPA medication, (3) early Huntington's disease (HD) patients, a disease that is associated with hyper-activation of the 'direct' pathway...
September 19, 2016: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/27576243/direct-parametric-reconstruction-with-joint-motion-estimation-correction-for-dynamic-brain-pet-data
#4
Jieqing Jiao, Alexandre Bousse, Kris Thielemans, Ninon Burgos, Philip Weston, Pawel Markiewicz, Jonathan Schott, David Atkinson, Simon Arridge, Brian Hutton, Sebastien Ourselin
Direct reconstruction of parametric images from raw photon counts has been shown to improve the quantitative analysis of dynamic positron emission tomography (PET) data. However it suffers from subject motion which is inevitable during the typical acquisition time of 1-2 hours. In this work we propose a framework to jointly estimate subject head motion and reconstruct the motion-corrected parametric images directly from raw PET data, so that the effects of distorted tissue-to-voxel mapping due to subject motion can be reduced in reconstructing the parametric images with motion-compensated attenuation correction and spatially aligned temporal PET data...
August 24, 2016: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/27557949/lack-of-association-between-dopaminergic-antagonism-and-negative-symptoms-in-schizophrenia-a-positron-emission-tomography-dopamine-d2-3-receptor-occupancy-study
#5
Gagan Fervaha, Fernando Caravaggio, David C Mamo, Benoit H Mulsant, Bruce G Pollock, Shinichiro Nakajima, Philip Gerretsen, Tarek K Rajji, Wanna Mar, Yusuke Iwata, Eric Plitman, Jun Ku Chung, Gary Remington, Ariel Graff-Guerrero
RATIONALE: Several pre-clinical studies suggest that antipsychotic medications cause secondary negative symptoms. However, direct evidence for a relationship among antipsychotic medications, their direct effects on neurotransmitter systems, and negative symptoms in schizophrenia remains controversial. OBJECTIVE: The objective of this study was to examine the relationship between antipsychotic-related dopamine D2/3 receptor occupancy and negative symptoms in patients with schizophrenia...
October 2016: Psychopharmacology
https://www.readbyqxmd.com/read/27467186/negative-association-of-pretreatment-cigarette-use-with-smoking-induced-striatal-dopamine-release-in-smokers-receiving-bupropion-treatment
#6
Aviv Malkiel Weinstein, Nanette Freedman, Joel Greif, Zipi Yemini, Eyal Mishani, Edythe London, Roland Chisin, Moshe Bocher
BACKGROUND AND OBJECTIVES: In an effort to help identify factors that maintain heavy smoking, this study tested the association of pretreatment cigarette use (cigarettes per day) with striatal dopamine release during smoking-cessation treatment. METHODS: Thirteen regular smokers (≥10 cigarettes per day) were evaluated on parameters of smoking behavior, and they entered a smoking cessation treatment protocol, including bupropion administration and individual counseling for 2 months...
September 2016: American Journal on Addictions
https://www.readbyqxmd.com/read/27459715/corticostriatal-and-dopaminergic-response-to-beer-flavor-with-both-fmri-and-11-c-raclopride-positron-emission-tomography
#7
Brandon G Oberlin, Mario Dzemidzic, Jaroslaw Harezlak, Maria A Kudela, Stella M Tran, Christina M Soeurt, Karmen K Yoder, David A Kareken
BACKGROUND: Cue-evoked drug-seeking behavior likely depends on interactions between frontal activity and ventral striatal (VST) dopamine (DA) transmission. Using [(11) C]raclopride (RAC) positron emission tomography (PET), we previously demonstrated that beer flavor (absent intoxication) elicited VST DA release in beer drinkers, inferred by RAC displacement. Here, a subset of subjects from this previous RAC-PET study underwent a similar paradigm during functional magnetic resonance imaging (fMRI) to test how orbitofrontal cortex (OFC) and VST blood oxygenation level-dependent (BOLD) responses to beer flavor are related to VST DA release and motivation to drink...
September 2016: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/27244237/association-between-striatal-dopamine-d2-d3-receptors-and-brain-activation-during-visual-attention-effects-of-sleep-deprivation
#8
D Tomasi, G-J Wang, N D Volkow
Sleep deprivation (SD) disrupts dopamine (DA) signaling and impairs attention. However, the interpretation of these concomitant effects requires a better understanding of dopamine's role in attention processing. Here we test the hypotheses that D2/D3 receptors (D2/D3R) in dorsal and ventral striatum would distinctly regulate the activation of attention regions and that, by decreasing D2/D3, SD would disrupt these associations. We measured striatal D2/D3R using positron emission tomography with [(11)C]raclopride and brain activation to a visual attention (VA) task using 4-Tesla functional magnetic resonance imaging...
2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27140603/extensive-graft-derived-dopaminergic-innervation-is-maintained-24-years-after-transplantation-in-the-degenerating-parkinsonian-brain
#9
Wen Li, Elisabet Englund, Håkan Widner, Bengt Mattsson, Danielle van Westen, Jimmy Lätt, Stig Rehncrona, Patrik Brundin, Anders Björklund, Olle Lindvall, Jia-Yi Li
Clinical trials using cells derived from embryonic ventral mesencephalon have shown that transplanted dopaminergic neurons can survive and function in the long term, as demonstrated by in vivo brain imaging using (18)F-fluorodopa and (11)C-raclopride positron emission tomography. Here we report the postmortem analysis of a patient with Parkinson's disease who 24 y earlier underwent unilateral transplantation of embryonic dopaminergic neurons in the putamen and subsequently exhibited major motor improvement and recovery of striatal dopaminergic function...
June 7, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27091456/reduction-of-dopamine-d2-3-receptor-binding-in-the-striatum-after-a-single-administration-of-esketamine-but-not-r-ketamine-a-pet-study-in-conscious-monkeys
#10
Kenji Hashimoto, Takeharu Kakiuchi, Hiroyuki Ohba, Shingo Nishiyama, Hideo Tsukada
R-ketamine appears to be a potent, long-lasting and safer antidepressant, relative to esketamine (S-ketamine), since it might be free of psychotomimetic side effects. Using [(11)C]raclopride and positron emission tomography (PET), we investigated whether esketamine and R-ketamine can affect dopamine D2/3 receptor binding in the conscious monkey brain. A single infusion of esketamine (0.5 mg/kg), but not R-ketamine (0.5 mg/kg), caused a reduction of binding availability of dopamine D2/3 receptor in the monkey striatum...
April 18, 2016: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/26954979/reduced-sleep-duration-mediates-decreases-in-striatal-d2-d3-receptor-availability-in-cocaine-abusers
#11
C E Wiers, E Shumay, E Cabrera, E Shokri-Kojori, T E Gladwin, E Skarda, S I Cunningham, S W Kim, T C Wong, D Tomasi, G-J Wang, N D Volkow
Neuroimaging studies have documented reduced striatal dopamine D2/D3 receptor (D2/D3R) availability in cocaine abusers, which has been associated with impaired prefrontal activity and vulnerability for relapse. However, the mechanism(s) underlying the decreases in D2/D3R remain poorly understood. Recent studies have shown that sleep deprivation is associated with a downregulation of striatal D2/D3R in healthy volunteers. As cocaine abusers have disrupted sleep patterns, here we investigated whether reduced sleep duration mediates the relationship between cocaine abuse and low striatal D2/D3R availability...
March 8, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/26911894/longitudinal-imaging-of-the-availability-of-dopamine-transporter-and-d2-receptor-in-rat-striatum-following-mild-ischemia
#12
Sotaro Momosaki, Miwa Ito, Hiroko Yamato, Hitoshi Iimori, Hirokazu Sumiyoshi, Kenji Morimoto, Natsumi Imamoto, Tadashi Watabe, Eku Shimosegawa, Jun Hatazawa, Kohji Abe
The changes in the availability of striatal dopamine transporter and dopamine D2 receptor after mild focal ischemia in rats were measured using a small animal positron emission tomography system. Mild focal ischemia was induced by 20-minute middle cerebral artery occlusion. [(11)C]PE2I binding to dopamine transporter was transiently increased on the ipsilateral side of the striatum at 2 days after middle cerebral artery occlusion. On day 7 and 14 after middle cerebral artery occlusion, [(11)C]PE2I binding levels were decreased...
February 24, 2016: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/26905412/dopamine-cross-sensitization-between-psychostimulant-drugs-and-stress-in-healthy-male-volunteers
#13
L Booij, K Welfeld, M Leyton, A Dagher, I Boileau, I Sibon, G B Baker, M Diksic, J-P Soucy, J C Pruessner, E Cawley-Fiset, K F Casey, C Benkelfat
Dysregulation of the stress response system is a potential etiological factor in the development of and relapse to multiple neuropsychiatric disorders. Previously we reported that repeated intermittent d-amphetamine administration can lead to progressively greater dopamine release, thereby providing evidence of drug-induced neurochemical sensitization. Here, we test the hypothesis that repeated exposure to d-amphetamine increases dopaminergic responses to stress; that is, produces cross-sensitization. Using positron emission tomography, we measured in 17 healthy male volunteers (mean ± s...
2016: Translational Psychiatry
https://www.readbyqxmd.com/read/26877079/the-role-of-dopamine-in-value-based-attentional-orienting
#14
Brian A Anderson, Hiroto Kuwabara, Dean F Wong, Emily G Gean, Arman Rahmim, James R Brašić, Noble George, Boris Frolov, Susan M Courtney, Steven Yantis
Reward learning gives rise to strong attentional biases. Stimuli previously associated with reward automatically capture visual attention regardless of intention. Dopamine signaling within the ventral striatum plays an important role in reward learning, representing the expected reward initiated by a cue. How dopamine and the striatum may be involved in maintaining behaviors that have been shaped by reward learning, even after reward expectancies have changed, is less well understood. Nonspecific measures of brain activity have implicated the striatum in value-based attention...
February 22, 2016: Current Biology: CB
https://www.readbyqxmd.com/read/26863655/ossi-pet-open-access-database-of-simulated-11-c-raclopride-scans-for-the-inveon-preclinical-pet-scanner-application-to-the-optimization-of-reconstruction-methods-for-dynamic-studies
#15
Marie-Paule Garcia, Arnaud Charil, Paul Callaghan, Catriona Wimberley, Florian Busso, Marie-Claude Gregoire, Manuel Bardies, Anthonin Reilhac
A wide range of medical imaging applications benefits from the availability of realistic ground truth data. In the case of positron emission tomography (PET), ground truth data is crucial to validate processing algorithms and assessing their performances. The design of such ground truth data often relies on Monte-Carlo simulation techniques. Since the creation of a large dataset is not trivial both in terms of computing time and realism, we propose the OSSI-PET database containing 350 simulated [(11)C]Raclopride dynamic scans for rats, created specifically for the Inveon pre-clinical PET scanner...
July 2016: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/26828302/socioeconomic-status-is-associated-with-striatal-dopamine-d2-d3-receptors-in-healthy-volunteers-but-not-in-cocaine-abusers
#16
Corinde E Wiers, Ehsan Shokri-Kojori, Elizabeth Cabrera, Samantha Cunningham, Christopher Wong, Dardo Tomasi, Gene-Jack Wang, Nora D Volkow
Positron emission tomography (PET) studies in animals and humans have shown that social status is associated with striatal dopamine D2/D3 receptor (D2/D3R) availability. That is, higher social hierarchy and higher scores on questionnaires assessing social status correlated positively with striatal D2/D3R availability in animals and humans respectively. Furthermore, subordinate monkeys were vulnerable to cocaine self-administration, suggesting that alternations in social hierarchy can change D2/D3R availability and vulnerability to cocaine use...
March 23, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/26821979/contribution-of-non-genetic-factors-to-dopamine-and-serotonin-receptor-availability-in-the-adult-human-brain
#17
J Borg, S Cervenka, R Kuja-Halkola, G J Matheson, E G Jönsson, P Lichtenstein, S Henningsson, T Ichimiya, H Larsson, P Stenkrona, C Halldin, L Farde
The dopamine (DA) and serotonin (5-HT) neurotransmission systems are of fundamental importance for normal brain function and serve as targets for treatment of major neuropsychiatric disorders. Despite central interest for these neurotransmission systems in psychiatry research, little is known about the regulation of receptor and transporter density levels. This lack of knowledge obscures interpretation of differences in protein availability reported in psychiatric patients. In this study, we used positron emission tomography (PET) in a twin design to estimate the relative contribution of genetic and environmental factors, respectively, on dopaminergic and serotonergic markers in the living human brain...
August 2016: Molecular Psychiatry
https://www.readbyqxmd.com/read/26790869/decreased-dopamine-transporter-and-receptor-ligand-binding-in-parkinsonism-with-diabetic-uremic-syndrome
#18
Kazuhiro Ishii, Kenji Ishii, Ayako Shioya, Kiyotaka Nemoto, Akira Tamaoka
Here, we describe the case of a 47-year-old man with bilateral striatal lesions with diabetic uremia. Following 4 years of hemodialysis, the patient experienced sudden onset of rigidity, bradykinesia, gait disorder, and postural instability. Symptoms were remediated 2 months later, and were no longer responsive to levodopa approximately 1 year after the onset. Brain magnetic resonance imaging (MRI) during the acute phase showed T 2-weighted high signal edematous lesions in the bilateral striatum, subsequently developing into vacuolated lesions...
May 2016: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/26732626/striatal-dopaminergic-reward-response-relates-to-age-of-first-drunkenness-and-feedback-response-in-at-risk-youth
#19
Barbara J Weiland, Robert A Zucker, Jon-Kar Zubieta, Mary M Heitzeg
Dopamine receptor concentrations, primarily in the striatum, are hypothesized to contribute to a developmental imbalance between subcortical and prefrontal control systems in emerging adulthood potentially biasing motivation and increasing risky behaviors. Positron emission tomography studies have found significant reductions in striatal dopamine D2 receptors, and blunted amphetamine-induced dopamine release, in substance users compared with healthy controls. Extant literature is limited and inconsistent concerning vulnerability associated with having a family history of substance abuse (FH+)...
January 5, 2016: Addiction Biology
https://www.readbyqxmd.com/read/26661171/exploring-the-use-of-shape-and-texture-descriptors-of-positron-emission-tomography-tracer-distribution-in-imaging-studies-of-neurodegenerative-disease
#20
Ivan S Klyuzhin, Marjorie Gonzalez, Elham Shahinfard, Nasim Vafai, Vesna Sossi
Positron emission tomography (PET) data related to neurodegeneration are most often quantified using methods based on tracer kinetic modeling. In contrast, here we investigate the ability of geometry and texture-based metrics that are independent of kinetic modeling to convey useful information on disease state. The study was performed using data from Parkinson's disease subjects imaged with (11)C-dihydrotetrabenazine and (11)C-raclopride. The pattern of the radiotracer distribution in the striatum was quantified using image-based metrics evaluated over multiple regions of interest that were defined on co-registered PET and MRI images...
June 2016: Journal of Cerebral Blood Flow and Metabolism
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