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https://www.readbyqxmd.com/read/28416594/new-repeat-polymorphism-in-the-akt1-gene-predicts-striatal-dopamine-d2-d3-receptor-availability-and-stimulant-induced-dopamine-release-in-the-healthy-human-brain
#1
Elena Shumay, Corinde E Wiers, Ehsan Shokri-Kojori, Sung Won Kim, Colin A Hodgkinson, Hui Sun, Dardo Tomasi, Christopher T Wong, Daniel R Weinberger, Gene-Jack Wang, Joanna S Fowler, Nora D Volkow
The role of the protein kinase Akt1 in dopamine neurotransmission is well recognized and has been implicated in schizophrenia and psychosis. However, the extent to which variants in the AKT1 gene influence dopamine neurotransmission is not well understood.Here we investigated the effect of a newly characterized variant number tandem repeat (VNTR) polymorphism in AKT1 (major alleles: L- (8 repeats) and H- (9 repeats)) on striatal dopamine D2/D3 receptor (DRD2) availability and on dopamine release in healthy volunteers...
April 17, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28407307/adenosine-a1-receptors-measured-with-11-c-mpdx-pet-in-early-parkinson-s-disease
#2
Masahiro Mishina, Kenji Ishii, Yuichi Kimura, Masahiko Suzuki, Shin Kitamura, Kenji Ishibashi, Muneyuki Sakata, Keiichi Oda, Shiro Kobayashi, Kazumi Kimura, Kiichi Ishiwata
Adenosine A1 receptors (A1 Rs) interact negatively with dopamine D1 receptors (D1 Rs) in neurons of the basal ganglia's direct pathway, while adenosine A2A receptors (A2A Rs) negatively interact with dopamine D2 receptors (D2 Rs) in indirect-pathway neurons. The aim of this study was to investigate the cerebral density of A1 Rs in Parkinson's disease (PD) in its early stages, using PET scans with the radioligand 8-dicyclopropylmethyl-1-(11) C-methyl-3-propylxanthine ((11) C-MPDX). We studied 10 drug-naïve patients with early PD...
April 13, 2017: Synapse
https://www.readbyqxmd.com/read/28365375/preclinical-molecular-imaging-of-glutamatergic-and-dopaminergic-neuroreceptor-kinetics-in-obsessive-compulsive-disorder
#3
S Servaes, D Glorie, J Verhaeghe, S Stroobants, S Staelens
BACKGROUND: Molecular neuroimaging was applied in the quinpirole rat model for compulsive checking in OCD to visualize the D2- and mGluR5-receptor occupancy with Raclopride and ABP-688 microPET/CT. METHODS: Animals (n=48) were exposed to either saline (CTRL; 1mL/kg) or quinpirole (QP; dopamine D2-agonist, 0.5mg/kg) in a single injection (RAC and ABP acute groups) or twice-weekly during 7weeks (chronic group). Animals underwent PET/CT after the 1st injection (acute) or before initial exposure and following the 10th injection in week 5 (chronic)...
March 30, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28356473/density-of-available-striatal-dopamine-receptors-predicts-trait-impulsiveness-during-performance-of-an-attention-demanding-task
#4
Brian A Anderson, Hiroto Kuwabara, Dean F Wong, Susan M Courtney
The density (measured at binding potential) of available striatal D2/D3 receptors has been shown to predict trait impulsiveness. This relationship is highly robust and well replicated. In each case, however, the availability of dopamine receptors was measured at rest. More broadly, the extent to which relationships between dopamine receptor availability and behavioral traits holds when participants perform a cognitive task is unclear. Furthermore, the performance of a cognitive task engages fundamentally different neural networks than are maximally engaged during the resting state...
March 29, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28356463/dopamine-d2-d3-imbalance-during-migraine-attack-and-allodynia-in-vivo
#5
Alexandre F DaSilva, Thiago D Nascimento, Hassan Jassar, Joseph Heffernan, Rebecca L Toback, Sarah Lucas, Marcos F DosSantos, Emily L Bellile, Philip S Boonstra, Jeremy M G Taylor, Kenneth L Casey, Robert A Koeppe, Yolanda R Smith, Jon-Kar Zubieta
OBJECTIVE: To evaluate in vivo the dynamics of endogenous dopamine (DA) neurotransmission during migraine ictus with allodynia. METHODS: We examined 8 episodic migraineurs and 8 healthy controls (HC) using PET with [(11)C]raclopride. The uptake measure of [(11)C]raclopride, nondisplaceable binding potential (BPND), would increase when there was a reduction in endogenous DA release. The opposite is true for a decrease in [(11)C]raclopride BPND. Patients were scanned twice: one PET session was during a spontaneous migraine ictus at rest, followed by a sustained thermal pain threshold (STPT) challenge on the trigeminal region, eliciting an allodynia experience; another was during interictal phase...
March 29, 2017: Neurology
https://www.readbyqxmd.com/read/28350401/systemic-inflammation-enhances-stimulant-induced-striatal-dopamine-elevation
#6
J R Petrulli, B Kalish, N B Nabulsi, Y Huang, J Hannestad, E D Morris
Changes in the mesolimbic dopamine (DA) system are implicated in a range of neuropsychiatric conditions including addiction, depression and schizophrenia. Dysfunction of the neuroimmune system is often comorbid with such conditions and affects similar areas of the brain. The goal of this study was to use positron emission tomography with the dopamine D2 antagonist tracer, (11)C-raclopride, to explore the effect of acute immune activation on striatal DA levels. DA transmission was modulated by an oral methylphenidate (MP) challenge in order to reliably elicit DA elevation...
March 28, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28346539/is-there-a-relation-between-novelty-seeking-striatal-dopamine-release-and-frontal-cortical-thickness
#7
Natalia Jaworska, Sylvia M Cox, Kevin F Casey, Isabelle Boileau, Mariya Cherkasova, Kevin Larcher, Alain Dagher, Chawki Benkelfat, Marco Leyton
BACKGROUND: Novelty-seeking (NS) and impulsive personality traits have been proposed to reflect an interplay between fronto-cortical and limbic systems, including the limbic striatum (LS). Although neuroimaging studies have provided some evidence for this, most are comprised of small samples and many report surprisingly large effects given the challenges of trying to relate a snapshot of brain function or structure to an entity as complex as personality. The current work tested a priori hypotheses about associations between striatal dopamine (DA) release, cortical thickness (CT), and NS in a large sample of healthy adults...
2017: PloS One
https://www.readbyqxmd.com/read/28284952/importance-of-d1-and-d2-receptor-stimulation-for-the-induction-and-expression-of-cocaine-induced-behavioral-sensitization-in-preweanling-rats
#8
Sanders A McDougall, Krista N Rudberg, Ana Veliz, Janhavi M Dhargalkar, Aleesha S Garcia, Loveth C Romero, Ashley E Gonzalez, Alena Mohd-Yusof, Cynthia A Crawford
The behavioral manifestations of psychostimulant-induced sensitization vary markedly between young and adult rats, suggesting that the neural mechanisms mediating this phenomenon differ across ontogeny. In this project we examined the importance of D1 and D2 receptors for the induction and expression of cocaine-induced behavioral sensitization during the preweanling period. In the behavioral experiments, rats were injected with reversible D1 and/or D2 antagonists (SCH23390 and/or raclopride) or an irreversible receptor antagonist (EEDQ) either before cocaine administration on the pretreatment day (induction) or before cocaine challenge on the test day (expression)...
March 8, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28254508/patterns-of-age-related-changes-for-phosphodiesterase-type-10a-in-comparison-with-dopamine-d2-3-receptors-and-sub-cortical-volumes-in-the-human-basal-ganglia-a-pet-study-with-18-f-mni-659-and-11-c-raclopride-with-correction-for-partial-volume-effect
#9
Patrik Fazio, Martin Schain, Ladislav Mrzljak, Nahid Amini, Sangram Nag, Nabil Al-Tawil, Cheryl J Fitzer-Attas, Juliana Bronzova, Bernhard Landwehrmeyer, Cristina Sampaio, Christer Halldin, Andrea Varrone
Phosphodiesterase 10A enzyme (PDE10A) is an important striatal target that has been shown to be affected in patients with neurodegenerative disorders, particularly Huntington´s disease (HD). PDE10A is expressed on striatal neurones in basal ganglia where other known molecular targets are enriched such as dopamine D2/3 receptors (D2/3 R). The aim of this study was to examine the availability of PDE10A enzyme in relation with age and gender and to compare those changes with those related to D2/3 R and volumes in different regions of the basal ganglia...
February 28, 2017: NeuroImage
https://www.readbyqxmd.com/read/28239334/micropet-outperforms-beta-microprobes-in-determining-neuroreceptor-availability-under-pharmacological-restriction-for-cold-mass-occupancy
#10
Dorien Glorie, Stijn Servaes, Jeroen Verhaeghe, Tine Wyckhuys, Leonie Wyffels, Olivier Vanderveken, Sigrid Stroobants, Steven Staelens
Both non-invasive micro-positron emission tomography (μPET) and in situ beta-microprobes have the ability to determine radiotracer kinetics and neuroreceptor availability in vivo. Beta-microprobes were proposed as a cost-effective alternative to μPET, but literature revealed conflicting results most likely due to methodological differences and inflicted tissue damage. The current study has three main objectives: (i) evaluate the theoretical advantages of beta-microprobes; (ii) perform μPET imaging to assess the impact of (beta-micro)probe implantation on relative tracer delivery (R1) and receptor occupancy (non-displaceable binding potential, BPND) in the rat brain; and (iii) investigate whether beta-microprobe recordings produce robust results when a pharmacological restriction for cold mass dose (tracer dose condition) is imposed...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28132915/dopamine-d2-receptors-mediate-the-increase-in-reinstatement-of-the-conditioned-rewarding-effects-of-cocaine-induced-by-acute-social-defeat
#11
Marina Daiana Reguilón, Sandra Montagud-Romero, Carmen Ferrer-Pérez, Concepción Roger-Sánchez, María Asunción Aguilar, José Miñarro, Marta Rodríguez-Arias
Social stress modifies the activity of brain areas involved in the rewarding effects of psychostimulants, inducing neuroadaptations in the dopaminergic mesolimbic system and modifying the sensitivity of dopamine receptors. In the present study we evaluated the effect of the dopamine D1- and D2-like receptor antagonists (SCH23390 and raclopride, respectively) on the short-time effects of acute social defeat (ASD). Male OF1 mice were socially defeated before each conditioning session of the conditioned place preference (CPP) induced by 1mg/kg or 25mg/kg of cocaine plus the corresponding dopamine antagonist...
January 26, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28124114/activation-of-ventral-tegmental-area-dopamine-neurons-produces-wakefulness-through-dopamine-d2-like-receptors-in-mice
#12
Yo Oishi, Yoshiaki Suzuki, Koji Takahashi, Toshiya Yonezawa, Takeshi Kanda, Yohko Takata, Yoan Cherasse, Michael Lazarus
A growing body of evidence suggests that dopamine plays a role in sleep-wake regulation, but the dopamine-producing brain areas that control sleep-wake states are unclear. In this study, we chemogenetically activated dopamine neurons in the ventral midbrain of mice to examine the role of these neurons in sleep-wake regulation. We found that activation of dopamine neurons in the ventral tegmental area (VTA), but not in the substantia nigra, strongly induced wakefulness, although both cell populations expressed the neuronal activity marker c-Fos after chemogenetic stimulation...
January 25, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28123032/role-of-dorsomedial-striatum-neuronal-ensembles-in-incubation-of-methamphetamine-craving-after-voluntary-abstinence
#13
Daniele Caprioli, Marco Venniro, Michelle Zhang, Jennifer M Bossert, Brandon L Warren, Bruce T Hope, Yavin Shaham
We recently developed a rat model of incubation of methamphetamine craving after choice-based voluntary abstinence. Here, we studied the role of dorsolateral striatum (DLS) and dorsomedial striatum (DMS) in this incubation. We trained rats to self-administer palatable food pellets (6 d, 6 h/d) and methamphetamine (12 d, 6 h/d). We then assessed relapse to methamphetamine seeking under extinction conditions after 1 and 21 abstinence days. Between tests, the rats underwent voluntary abstinence (using a discrete choice procedure between methamphetamine and food; 20 trials/d) for 19 d...
January 25, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28113619/direct-parametric-reconstruction-with-joint-motion-estimation-correction-for-dynamic-brain-pet-data
#14
Jieqing Jiao, Alexandre Bousse, Kris Thielemans, Ninon Burgos, Philip Weston, Pawel Markiewicz, Jonathan Schott, David Atkinson, Simon Arridge, Brian Hutton, Sebastien Ourselin
Direct reconstruction of parametric images from raw photon counts has been shown to improve the quantitative analysis of dynamic positron emission tomography (PET) data. However it suffers from subject motion which is inevitable during the typical acquisition time of 1-2 hours. In this work we propose a framework to jointly estimate subject head motion and reconstruct the motion-corrected parametric images directly from raw PET data, so that the effects of distorted tissue-to-voxel mapping due to subject motion can be reduced in reconstructing the parametric images with motion-compensated attenuation correction and spatially aligned temporal PET data...
August 24, 2016: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28108253/dcc-haploinsufficiency-regulates-dopamine-receptor-expression-across-postnatal-lifespan
#15
Matthew Pokinko, Alanna Grant, Florence Shahabi, Yvan Dumont, Colleen Manitt, Cecilia Flores
Adolescence is a period during which the medial prefrontal cortex (mPFC) undergoes significant remodeling. The netrin-1 receptor, deleted in colorectal cancer (DCC), controls the extent and organization of mPFC dopamine connectivity during adolescence and in turn directs mPFC functional and structural maturation. Dcc haploinsufficiency leads to increased mPFC dopamine input, which causes improved cognitive processing and resilience to behavioral effects of stimulant drugs of abuse. Here we examine the effects of Dcc haploinsufficiency on the dynamic expression of dopamine receptors in forebrain targets of C57BL6 mice...
March 27, 2017: Neuroscience
https://www.readbyqxmd.com/read/28063918/simultaneous-in-vivo-receptor-occupancy-assays-for-serotonin-1a-2a-and-dopamine-2-receptors-with-the-use-of-non-radiolabelled-tracers-proposed-method-in-screening-antipsychotics
#16
Jagadeesh Babu Thentu, Ramakrishna Nirogi, Gopinadh Bhyrapuneni, Devender Reddy Ajjala, Raghupathi Reddy Aleti, Raghava Choudary Palacharla
INTRODUCTION: Conventionally, receptor occupancy assays employ radiolabelled tracer. However, recent advances with non-radiolabelled tracers brought a revolution in target engagement assays. Non-radiolabelled tracer based receptor occupancy uses LC-MS/MS based quantification. It offers simultaneous quantification of more than one tracer; thus, provides the feasibility of evaluating multiple targets in a single animal. In the present study, we demonstrated simultaneous measurement of serotonin 1A, serotonin 2A, and dopamine 2 receptor occupancy using non-radiolabelled tracers in rats...
January 4, 2017: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/27984698/simultaneous-voltammetric-measurements-of-glucose-and-dopamine-demonstrate-the-coupling-of-glucose-availability-with-increased-metabolic-demand-in-the-rat-striatum
#17
Samantha K Smith, Christie A Lee, Matthew E Dausch, Brian M Horman, Heather B Patisaul, Gregory S McCarty, Leslie A Sombers
Cerebral blood flow ensures delivery of nutrients, such as glucose, to brain sites with increased metabolic demand. However, little is known about rapid glucose dynamics at discrete locations during neuronal activation in vivo. Acute exposure to many substances of abuse elicits dopamine release and neuronal activation in the striatum; however, the concomitant changes in striatal glucose remain largely unknown. Recent developments have combined fast-scan cyclic voltammetry with glucose oxidase enzyme modified carbon-fiber microelectrodes to enable the measurement of glucose dynamics with subsecond temporal resolution in the mammalian brain...
January 17, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/27984074/alterations-in-ventral-and-dorsal-striatal-allosteric-a2ar-d2r-receptor-receptor-interactions-after-amphetamine-challenge-relevance-for-schizophrenia
#18
Julia Pintsuk, Dasiel O Borroto-Escuela, Terence K Y Lai, Fang Liu, Kjell Fuxe
Striatal dopamine D2R homodimerization is increased in the dorsal striatum after acute amphetamine challenge and in the amphetamine-induced sensitized state, a well-known animal model of schizophrenia. Therefore, it was tested if the increase in D2R homoreceptor complexes found after acute amphetamine challenge in the saline or the amphetamine sensitized state leads to changes in the antagonistic adenosine A2AR-D2R interactions in the striatum. [(3)H]-raclopride binding was performed in membrane preparations from the ventral and dorsal striatum involving competition with the D2R like agonist quinpirole...
October 29, 2016: Life Sciences
https://www.readbyqxmd.com/read/27981179/striatal-dopamine-d2-3-receptor-regulation-by-stress-inoculation-in-squirrel-monkeys
#19
Alex G Lee, Jordan M Nechvatal, Bin Shen, Christine L Buckmaster, Michael J Levy, Frederick T Chin, Alan F Schatzberg, David M Lyons
Intermittent mildly stressful situations provide opportunities to learn, practice, and improve coping in a process called stress inoculation. Stress inoculation also enhances cognitive control and response inhibition of impulsive motivated behavior. Cognitive control and motivation have been linked to striatal dopamine D2 and/or D3 receptors (DRD2/3) in rodents, monkeys, and humans. Here, we study squirrel monkeys randomized early in life to stress inoculation with or without maternal companionship and a no-stress control treatment condition...
June 2016: Neurobiology of Stress
https://www.readbyqxmd.com/read/27980115/role-of-dorsomedial-striatum-neuronal-ensembles-in-incubation-of-methamphetamine-craving-after-voluntary-abstinence
#20
Daniele Caprioli, Marco Venniro, Michelle Zhang, Jennifer M Bossert, Brandon L Warren, Bruce T Hope, Yavin Shaham
We recently developed a rat model of incubation of methamphetamine craving after choice-based voluntary abstinence. Here, we studied the role of dorsolateral and dorsomedial striatum (DLS, DMS) in this incubation.We trained rats to self-administer palatable food pellets (6 days, 6-h/d) and methamphetamine (12 days, 6-h/d). We then assessed relapse to methamphetamine seeking under extinction conditions after 1 and 21 abstinence days. Between tests, the rats underwent voluntary abstinence (using a discrete choice procedure between methamphetamine and food; 20 trials/day) for 19 days...
December 15, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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