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https://www.readbyqxmd.com/read/28228174/fast-atomic-scale-elemental-mapping-of-crystalline-materials-by-stem-energy-dispersive-x-ray-spectroscopy-achieved-with-thin-specimens
#1
Ping Lu, Renliang Yuan, Jian Min Zuo
Elemental mapping at the atomic-scale by scanning transmission electron microscopy (STEM) using energy-dispersive X-ray spectroscopy (EDS) provides a powerful real-space approach to chemical characterization of crystal structures. However, applications of this powerful technique have been limited by inefficient X-ray emission and collection, which require long acquisition times. Recently, using a lattice-vector translation method, we have shown that rapid atomic-scale elemental mapping using STEM-EDS can be achieved...
February 2017: Microscopy and Microanalysis
https://www.readbyqxmd.com/read/28227405/template-based-rodent-brain-extraction-and-atlas-mapping
#2
Weimin Huang, Jiaqi Zhang, Zhiping Lin, Su Huang, Yuping Duan, Zhongkang Lu, Weimin Huang, Jiaqi Zhang, Zhiping Lin, Su Huang, Yuping Duan, Zhongkang Lu, Jiaqi Zhang, Weimin Huang, Yuping Duan, Zhongkang Lu, Zhiping Lin, Su Huang
Accurate rodent brain extraction is the basic step for many translational studies using MR imaging. This paper presents a template based approach with multi-expert refinement to automatic rodent brain extraction. We first build the brain appearance model based on the learning exemplars. Together with the template matching, we encode the rodent brain position into the search space to reliably locate the rodent brain and estimate the rough segmentation. With the initial mask, a level-set segmentation and a mask-based template learning are implemented further to the brain region...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227350/a-new-method-for-recognizing-hand-configurations-of-brazilian-gesture-language
#3
C F F Costa Filho, B L Dos Santos, R S de Souza, J R Dos Santos, M G F Costa, C F F Costa Filho, B L Dos Santos, R S de Souza, J R Dos Santos, M G F Costa, J R Dos Santos, M G F Costa, R S de Souza, C F F Costa Filho, B L Dos Santos
This paper describes a new method for recognizing hand configurations of the Brazilian Gesture Language - LIBRAS - using depth maps obtained with a Kinect® camera. The proposed method comprised three phases: hand segmentation, feature extraction, and classification. The segmentation phase is independent from the background and depends only on pixel depth information. Using geometric operations and numerical normalization, the feature extraction process was done independent from rotation and translation. The features are extracted employing two techniques: (2D)(2)LDA and (2D)(2)PCA...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227203/real-time-ultrasound-based-control-of-a-virtual-hand-by-a-trans-radial-amputee
#4
Clayton A Baker, Nima Akhlaghi, Huzefa Rangwala, Jana Kosecka, Siddhartha Sikdar, Clayton A Baker, Nima Akhlaghi, Huzefa Rangwala, Jana Kosecka, Siddhartha Sikdar, Nima Akhlaghi, Siddhartha Sikdar, Clayton A Baker, Jana Kosecka, Huzefa Rangwala
Advancements in multiarticulate upper-limb prosthetics have outpaced the development of intuitive, non-invasive control mechanisms for implementing them. Surface electromyography is currently the most popular non-invasive control method, but presents a number of drawbacks including poor deep-muscle specificity. Previous research established the viability of ultrasound imaging as an alternative means of decoding movement intent, and demonstrated the ability to distinguish between complex grasps in able-bodied subjects via imaging of the anterior forearm musculature...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28223012/3d-measurements-in-conventional-x-ray-imaging-with-rgb-d-sensors
#5
Francisco Albiol, Alberto Corbi, Alberto Albiol
A method for deriving 3D internal information in conventional X-ray settings is presented. It is based on the combination of a pair of radiographs from a patient and it avoids the use of X-ray-opaque fiducials and external reference structures. To achieve this goal, we augment an ordinary X-ray device with a consumer RGB-D camera. The patient' s rotation around the craniocaudal axis is tracked relative to this camera thanks to the depth information provided and the application of a modern surface-mapping algorithm...
February 17, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28218487/radiolabelled-polymeric-materials-for-imaging-and-treatment-of-cancer-quo-vadis
#6
REVIEW
Kritee Pant, Ondřej Sedláček, Robin A Nadar, Martin Hrubý, Holger Stephan
Owing to their tunable blood circulation time and suitable plasma stability, polymer-based nanomaterials hold a great potential for designing and utilising multifunctional nanocarriers for efficient imaging and effective treatment of cancer. When tagged with appropriate radionuclides, they may allow for specific detection (diagnosis) as well as the destruction of tumours (therapy) or even customization of materials, aiming to both diagnosis and therapy (theranostic approach). This review provides an overview of recent developments of radiolabelled polymeric nanomaterials (natural and synthetic polymers) for molecular imaging of cancer, specifically, applying nuclear techniques such as positron emission tomography (PET) and single-photon emission computed tomography (SPECT)...
February 20, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28218401/on-correction-of-translational-misalignments-between-section-planes-in-3d-ebsd
#7
O Šedivý, A Jäger
Three-dimensional electron backscatter diffraction allows obtaining the 3D image of a material from the stack of 2D sections. This is achieved by repeated application of two different beams; electron beam for electron backscatter diffraction mapping of the surface and focused ion beam for removing a thin layer of material from the surface. In most of these systems with two beams, the experiment requires stage movements for correct positioning of the sample to the respective beams. However, imperfections in this positioning are difficult to avoid, which yield small translational misalignments between the sections in the output data...
February 20, 2017: Journal of Microscopy
https://www.readbyqxmd.com/read/28217413/deformation-response-of-the-iliotibial-band-tensor-fascia-lata-complex-to-clinical-grade-longitudinal-tension-loading-in-vitro
#8
Mark Wilhelm, Omer Matthijs, Kevin Browne, Gesine Seeber, Anja Matthijs, Phillip S Sizer, Jean-Michel Brismée, C Roger James, Kerry K Gilbert
BACKGROUND: Iliotibial Band (ITB) syndrome is a troublesome condition with prevalence as high as 12% in runners. Stretching has been utilized as a conservative treatment. However, there is limited evidence supporting ITB elongation in response to a stretching force. PURPOSE/HYPOTHESES: The purpose of this study was to describe the iliotibial band tensor fascia lata complex (ITBTFLC) tissue elongation response to a simulated clinical stretch in-vitro. The authors hypothesized that the ITBTFLC would undergo statistically significant elongation when exposed to a clinical-grade stretching regimen, with the majority of the elongation occurring within the proximal ITBTFLC region...
February 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/28216588/3d-imaging-of-rapidly-spinning-space-targets-based-on-a-factorization-method
#9
Yanxian Bi, Shaoming Wei, Jun Wang, Shiyi Mao
Three-dimensional (3D) imaging of space targets can provide crucial information about the target shape and size, which are significant supports for the application of automatic target classification and recognition. In this paper, a new 3D imaging of space spinning targets via a factorization method is proposed. Firstly, after the translational compensation, the scattering centers two-dimensional (2D) range and range-rate sequence induced by the target spinning is extracted using a high resolution spectral estimation technique...
February 14, 2017: Sensors
https://www.readbyqxmd.com/read/28215155/magnetic-nanoparticles-new-perspectives-in-drug-delivery
#10
Joanna Wong, Jeremy Prout, Alexander Seifalian
BACKGROUND: The study of magnetic nanoparticles (MNPs) for drug delivery has recently seen a surge of interest even though the first studies were conducted as early as in the seventies. Despite this, there are still gaps in the knowledge of the field, implicating the complexities in designing the ideal MNP for drug delivery. The large surface area of MNPs and the ability to manipulate with an externally applied magnetic field render the MNP a good candidate for targeted delivery of drugs...
February 14, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28214968/piloting-the-use-of-patient-specific-cardiac-models-as-a-novel-tool-to-facilitate-communication-during-cinical-consultations
#11
Giovanni Biglino, Despina Koniordou, Marisa Gasparini, Claudio Capelli, Lindsay-Kay Leaver, Sachin Khambadkone, Silvia Schievano, Andrew M Taylor, Jo Wray
This pilot study aimed to assess the impact of using patient-specific three-dimensional (3D) models of congenital heart disease (CHD) during consultations with adolescent patients. Adolescent CHD patients (n = 20, age 15-18 years, 15 male) were asked to complete two questionnaires during a cardiology transition clinic at a specialist centre. The first questionnaire was completed just before routine consultation with the cardiologist, the second just after the consultation. During the consultation, each patient was presented with a 3D full heart model realised from their medical imaging data...
February 18, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28213330/drug-discovery-strategies-in-the-field-of-tumor-energy-metabolism-limitations-by-metabolic-flexibility-and-metabolic-resistance-to-chemotherapy
#12
REVIEW
N D Amoedo, E Obre, R Rossignol
The search for new drugs capable of blocking the metabolic vulnerabilities of human tumors has now entered the clinical evaluation stage, but several projects already failed in phase I or phase II. In particular, very promising in vitro studies could not be translated in vivo at preclinical stage and beyond. This was the case for most glycolysis inhibitors that demonstrated systemic toxicity. A more recent example is the inhibition of glutamine catabolism in lung adenocarcinoma that failed in vivo despite a strong addiction of several cancer cell lines to glutamine in vitro...
February 14, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28211634/prediction-of-forearm-bone-shape-based-on-partial-least-squares-regression-from-partial-shape
#13
Keiichiro Oura, Yoshito Otake, Atsuo Shigi, Futoshi Yokota, Tsuyoshi Murase, Yoshinobu Sato
BACKGROUND: Computer-assisted corrective osteotomy using a mirror image of the normal contralateral shape as reference is increasingly used. Instead, we propose to use the shape predicted by statistical learning to deal with cases demonstrating bilateral abnormality, such as bilateral trauma, congenital disease, and metabolic disease. METHODS: Computed tomography (CT) scans of 100 normal forearms were used in this study. The whole bone shape was predicted from its partial shape based on statistical learning of the other 99 bones...
February 17, 2017: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
https://www.readbyqxmd.com/read/28210206/the-unc-wisconsin-rhesus-macaque-neurodevelopment-database-a-structural-mri-and-dti-database-of-early-postnatal-development
#14
Jeffrey T Young, Yundi Shi, Marc Niethammer, Michael Grauer, Christopher L Coe, Gabriele R Lubach, Bradley Davis, Francois Budin, Rebecca C Knickmeyer, Andrew L Alexander, Martin A Styner
Rhesus macaques are commonly used as a translational animal model in neuroimaging and neurodevelopmental research. In this report, we present longitudinal data from both structural and diffusion MRI images generated on a cohort of 34 typically developing monkeys from 2 weeks to 36 months of age. All images have been manually skull stripped and are being made freely available via an online repository for use by the research community.
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28209913/rapid-imaging-of-tumor-cell-death-in-vivo-using-the-c2a-domain-of-synaptotagmin-i
#15
André A Neves, Bangwen Xie, Sarah Fawcett, Israt S Alam, Timothy H Witney, Maaike M de Backer, Julia Summers, William Hughes, Sarah McGuire, Dmitry Soloviev, Jodie Miller, William J Howat, De-En Hu, Tiago B Rodrigues, David Y Lewis, Kevin M Brindle
Cell death is an important target for imaging the early response of tumors to treatment. We describe here validation of a phosphatidylserine-binding agent for detecting tumor cell death in vivo based on the C2A domain of Synaptotagmin-I. Methods: The capability of near infrared fluorophore-labeled and 99mTechnetium- and (111)Indium-labeled derivatives of C2Am for imaging tumor cell death, using planar near infrared fluorescence (NIRF) imaging and single photon computed tomography (SPECT) respectively, was evaluated in implanted and genetically engineered mouse models of lymphoma and in a human colorectal xenograft...
February 16, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28209644/mitochondrial-dysfunction-induces-dendritic-loss-via-eif2%C3%AE-phosphorylation
#16
Taiichi Tsuyama, Asako Tsubouchi, Tadao Usui, Hiromi Imamura, Tadashi Uemura
Mitochondria are key contributors to the etiology of diseases associated with neuromuscular defects or neurodegeneration. How changes in cellular metabolism specifically impact neuronal intracellular processes and cause neuropathological events is still unclear. We here dissect the molecular mechanism by which mitochondrial dysfunction induced by Prel aberrant function mediates selective dendritic loss in Drosophila melanogaster class IV dendritic arborization neurons. Using in vivo ATP imaging, we found that neuronal cellular ATP levels during development are not correlated with the progression of dendritic loss...
February 16, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28207204/concise-review-increasing-the-validity-of-cerebrovascular-disease-models-and-experimental-methods-for-translational-stem-cell-research
#17
Johannes Boltze, Franziska Nitzsche, Jukka Jolkkonen, Gesa Weise, Claudia Pösel, Björn Nitzsche, Daniel-Christoph Wagner
Interspecies differences, anatomical and physiological aspects as wells as simplified study designs contribute to an overestimation of treatment effects and limit the transferability of experimental results into clinical applications. Confounders of cell therapies for cerebrovascular disorders (CVD) include common CVD comorbidities, frequent medications potentially affecting endogenous and transplanted stem cells, as well as age- and immune-system-related effects. All of those can contribute to a substantial modelling bias, ultimately limiting the prospective quality of preclinical research programs regarding the clinical value of a particular cell therapy...
February 16, 2017: Stem Cells
https://www.readbyqxmd.com/read/28205652/bridging-the-gap-microfluidic-devices-for-short-and-long-distance-cell-cell-communication
#18
REVIEW
Timothy Quang Vu, Ricardo Miguel Bessa de Castro, Lidong Qin
Cell-cell communication is a crucial component of many biological functions. For example, understanding how immune cells and cancer cells interact, both at the immunological synapse and through cytokine secretion, can help us understand and improve cancer immunotherapy. The study of how cells communicate and form synaptic connections is important in neuroscience, ophthalmology, and cancer research. But in order to increase our understanding of these cellular phenomena, better tools need to be developed that allow us to study cell-cell communication in a highly controlled manner...
February 16, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28205593/imaging-cardiac-scn5a-using-the-novel-f-18-radiotracer-radiocaine
#19
Jacob M Hooker, Martin G Strebl, Frederick A Schroeder, Hsiao-Ying Wey, Amrut V Ambardekar, Timothy A McKinsey, Matthias Schoenberger
The key function of the heart, a well-orchestrated series of contractions, is controlled by cardiac action potentials. These action potentials are initiated and propagated by a single isoform of voltage gated sodium channels - SCN5A. However, linking changes in SCN5A expression levels to human disease in vivo has not yet been possible. Radiocaine, an F-18 radiotracer for positron emission tomography (PET), is the first SCN5A imaging agent in the heart. Explants from healthy and failing human hearts were compared using radiocaine autoradiography to determine that the failing heart has ~30% lower SCN5A levels - the first evidence of changes in SCN5A expression in humans as a function of disease...
February 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28204959/phantom-study-investigating-the-accuracy-of-manual-and-automatic-image-fusion-with-the-ge-logiq-e9-implications-for-use-in-percutaneous-liver-interventions
#20
Mark Christiaan Burgmans, J Michiel den Harder, Philippa Meershoek, Nynke S van den Berg, Shaun Xavier Ju Min Chan, Fijs W B van Leeuwen, Arian R van Erkel
PURPOSE: To determine the accuracy of automatic and manual co-registration methods for image fusion of three-dimensional computed tomography (CT) with real-time ultrasonography (US) for image-guided liver interventions. MATERIALS AND METHODS: CT images of a skills phantom with liver lesions were acquired and co-registered to US using GE Logiq E9 navigation software. Manual co-registration was compared to automatic and semiautomatic co-registration using an active tracker...
February 15, 2017: Cardiovascular and Interventional Radiology
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