Bart R Thomson, Nina Schwendinger, Katrin Beckmann, Thomas Gentinetta, Daniel Couto, Sandra Wymann, Valérie Verdon, Raphael M Buzzi, Kevin Akeret, Peter W Kronen, Eva M Weinberger, Ulrike Held, Frauke Seehusen, Henning Richter, Dominik J Schaer, Michael Hugelshofer
Secondary brain injury (SBI) occurs with a lag of several days post-bleeding in patients with aneurysmal subarachnoid hemorrhage (aSAH) and is a strong contributor to mortality and long-term morbidity. aSAH-SBI coincides with cell-free hemoglobin (Hb) release into the cerebrospinal fluid. This temporal association and convincing pathophysiological concepts suggest that CSF-Hb could be a targetable trigger of SBI. However, sparse experimental evidence for Hb's neurotoxicity in vivo defines a significant research gap for clinical translation...
April 23, 2024: Translational Stroke Research