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https://www.readbyqxmd.com/read/28731877/simple-preoperative-ink-test-as-a-novel-adjunct-to-intrastromal-keratopigmentation-for-post-laser-peripheral-iridotomy-dysphotopsias
#1
Stephan Ong Tone, Daniel Q Li, Zach Ashkenazy, Armand Borovik, Allan R Slomovic, David S Rootman, Clara C Chan
PURPOSE: To describe a simple preoperative ink test as a novel adjunct to intrastromal keratopigmentation for post-laser peripheral iridotomy (LPI) dysphotopsias. METHODS: A surgical marking pen is applied to the area over a peripheral iridotomy before intrastromal keratopigmentation. The patient can then assess whether there is any improvement in their symptoms of dysphotopsias. Manual intrastromal keratopigmentation can then be performed using a crescent blade into the clear cornea at 50% depth and tunneled centrally to create a pocket ensuring that the peripheral iridotomy is fully occluded...
July 19, 2017: Cornea
https://www.readbyqxmd.com/read/28731865/-joining-the-spots-in-adults-and-young-tots-a-clinicopathological-study-of-henoch-sch%C3%A3-nlein-purpura-iga-vasculitis
#2
Priyanka P Kedia, Rajalakshmi Tirumalae, Divya Puttegowda, Meryl Antony
INTRODUCTION: Henoch-Schönlein Purpura (HSP; IgA vasculitis), the most common vasculitis of childhood, has a wide spectrum of clinical manifestations ranging from palpable purpura with abdominal pain and arthritis to the more morbid renal involvement. AIMS AND OBJECTIVES: To study and correlate the clinical presentation, laboratory values, skin and renal histopathology and immunofluoroscence findings in HSP. MATERIAL AND METHODS: A total of 44 cases of HSP from March 2011 to February 2014 were studied for the above features along with their clinical outcomes...
August 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28716777/customised-crescentic-corneal-transplant-with-conjunctival-resection-in-an-atypical-case-of-malignant-mooren-s-ulcer
#3
Jayanand Urkude, Rashmi Singh, Manthan Chaniyara, Amar Pujari
No abstract text is available yet for this article.
July 17, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28713246/differential-contribution-of-ca-2-dependent-mechanisms-to-hyperexcitability-in-layer-v-neurons-of-the-medial-entorhinal-cortex
#4
Eric C Lin, Crescent L Combe, Sonia Gasparini
Temporal lobe epilepsy is characterized by recurrent seizures in one or both temporal lobes of the brain; some in vitro models show that epileptiform discharges initiate in entorhinal layer V neurons and then spread into other areas of the temporal lobe. We previously found that, in the presence of GABAA receptor antagonists, stimulation of afferent fibers, terminating both at proximal and distal dendritic locations, initiated hyperexcitable bursts in layer V medial entorhinal neurons. We investigated the differential contribution of Ca(2+)-dependent mechanisms to the plateaus underlying these bursts at proximal and distal synapses...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28712056/the-crescent-sign-in-pneumatic-reduction-of-intussusception
#5
REVIEW
Man Leung Yu, Kam Ho Lee, Yan Lin Li
No abstract text is available yet for this article.
July 15, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28700996/immunosuppressive-treatment-in-c3-glomerulopathy-is-it-really-effective
#6
Yasar Caliskan, Ege Sinan Torun, Tarik Onur Tiryaki, Aysegul Oruc, Yasemin Ozluk, Sebahat Usta Akgul, Sonay Temurhan, Nida Oztop, Isin Kilicaslan, Mehmet Sukru Sever
BACKGROUND: C3 glomerulopathy (C3GP) is a recently identified and described disease that has a high risk of progressing into end-stage renal disease. We aimed to evaluate the effects of various immunosuppressive regimens on C3GP progression because there are conflicting data on the treatment modalities. METHODS: In this retrospective study of 66 patients with C3GP, 27 patients received mycophenolate mofetil (MMF)-based treatment, 23 received non-MMF-based treatment (prednisolone or cyclophosphamide), and 16 received conservative care...
July 13, 2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/28699638/bcat1-controls-metabolic-reprogramming-in-activated-human-macrophages-and-is-associated-with-inflammatory-diseases
#7
Adonia E Papathanassiu, Jeong-Hun Ko, Martha Imprialou, Marta Bagnati, Prashant K Srivastava, Hong A Vu, Danilo Cucchi, Stephen P McAdoo, Elitsa A Ananieva, Claudio Mauro, Jacques Behmoaras
Branched-chain aminotransferases (BCAT) are enzymes that initiate the catabolism of branched-chain amino acids (BCAA), such as leucine, thereby providing macromolecule precursors; however, the function of BCATs in macrophages is unknown. Here we show that BCAT1 is the predominant BCAT isoform in human primary macrophages. We identify ERG240 as a leucine analogue that blocks BCAT1 activity. Selective inhibition of BCAT1 activity results in decreased oxygen consumption and glycolysis. This decrease is associated with reduced IRG1 levels and itaconate synthesis, suggesting involvement of BCAA catabolism through the IRG1/itaconate axis within the tricarboxylic acid cycle in activated macrophages...
July 12, 2017: Nature Communications
https://www.readbyqxmd.com/read/28698271/mannose-binding-lectin-levels-could-predict-prognosis-in-iga-nephropathy
#8
Wei-Yi Guo, Li Zhu, Si-Jun Meng, Su-Fang Shi, Li-Jun Liu, Ji-Cheng Lv, Hong Zhang
IgA nephropathy (IgAN) is characterized by infections followed by episodic gross hematuria. Deficiency of mannose-binding lectin (MBL) is associated with recurrent infection in many diseases, but controversy exists regarding the role of MBL in IgAN. Here, we measured MBL2 variants and MBL levels in 749 patients with IgAN and 489 healthy controls. Overall, 5.2% (39 of 749) of patients with IgAN had MBL deficiency (MBL levels <100 ng/ml), among whom LYPB/LYPB and LXPA/LYPB were the predominant MBL2 haplotypes (82%; 32 of 39)...
July 11, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28691246/formation-and-function-of-the-xestoleberis-spot-in-xestoleberis-hanaii-crustacea-ostracoda
#9
Shinnosuke Yamada
The crescent sculpture of the so-called "Xestoleberis-spot" develops inside the calcified valve of the family Xestoleberididae. Electron microscopic observations on both, intermoult and postmoult stages of Xestoleberis species reveal that the "Xestoleberis-spot" system consists of three elements; two calcified chambers, a vesicle of electron-dense material and an uncalcified procuticle. The formation and function of the "Xestoleberis-spot" system are discussed. In conclusion, the "Xestoleberis-spot" system functions as the muscle attachment site for several antennal muscles, and provides the material for chitinous fibers in the exocuticle of outer lamella...
July 10, 2017: Journal of Morphology
https://www.readbyqxmd.com/read/28690114/maintenance-of-miranda-localization-in-drosophila-neuroblasts-involves-interaction-with-the-cognate-mrna
#10
Anne Ramat, Matthew Hannaford, Jens Januschke
How cells position their proteins is a key problem in cell biology. Targeting mRNAs to distinct regions of the cytoplasm contributes to protein localization by providing local control over translation. Here, we reveal that an interdependence of a protein and cognate mRNA maintains asymmetric protein distribution in mitotic Drosophila neural stem cells. We tagged endogenous mRNA or protein products of the gene miranda that is required for fate determination with GFP. We find that the mRNA localizes like the protein it encodes in a basal crescent in mitosis...
July 5, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28688878/retrospective-review-of-billowing-phenomenon-a-mimic-of-endoleak-following-placement-of-endologix-covered-stent-for-the-treatment-of-abdominal-aortic-aneurysm
#11
Naseem Helo, Arthur C Chang, Christine Hyun, Christian Bianchi, Theodore H Teruya, Alex C Yi, Kenneth S Chon
BACKGROUND: Billowing is a unique CT finding of the Endologix stent graft where a rim of contrast is observed outside the stent's endoskeleton but still contained within the graft cover. The purpose of this study is to evaluate the incidence and clinical outcome of billowing following an Endologix stent graft placement. METHODS: All patients who underwent Abdominal Aortic Aneurysm (AAA) repair with endovascular placement of an Endologix stent graft from January 2002-September 2013 that were followed with imaging were included in the study...
July 5, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28687535/endothelial-nf-%C3%AE%C2%BAb-blockade-abrogates-anca-induced-gn
#12
Mira Choi, Adrian Schreiber, Claudia Eulenberg-Gustavus, Claus Scheidereit, Jan Kamps, Ralph Kettritz
ANCA-associated vasculitis (AAV) is a highly inflammatory condition in which ANCA-activated neutrophils interact with the endothelium, resulting in necrotizing vasculitis. We tested the hypothesis that endothelial NF-κB mediates necrotizing crescentic GN (NCGN) and provides a specific treatment target. Reanalysis of kidneys from previously examined murine NCGN disease models revealed NF-κB activation in affected kidneys, mostly as a p50/p65 heterodimer, and increased renal expression of NF-κB-dependent tumor necrosis factor α (TNF-α)...
July 7, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28686718/morphological-variation-phylogenetic-relationships-and-geographic-distribution-of-the-baenidae-testudines-based-on-new-specimens-from-the-uinta-formation-uinta-basin-utah-usa
#13
Heather F Smith, J Howard Hutchison, K E Beth Townsend, Brent Adrian, Daniel Jager
We described newly discovered baenid specimens from the Uintan North American Land Mammal Age (NALMA), in the Uinta Formation, Uinta Basin, Utah. These specimens include a partial skull and several previously undescribed postcranial elements of Baena arenosa, and numerous well-preserved shells of B. arenosa and Chisternon undatum. Baenids from the Uintan NALMA (46.5-40 Ma) are critical in that they provide valuable insight into the morphology and evolution of the diverse and speciose baenid family near the end of its extensive radiation, just prior to the disappearance of this clade from the fossil record...
2017: PloS One
https://www.readbyqxmd.com/read/28684525/wild-emmer-genome-architecture-and-diversity-elucidate-wheat-evolution-and-domestication
#14
Raz Avni, Moran Nave, Omer Barad, Kobi Baruch, Sven O Twardziok, Heidrun Gundlach, Iago Hale, Martin Mascher, Manuel Spannagl, Krystalee Wiebe, Katherine W Jordan, Guy Golan, Jasline Deek, Batsheva Ben-Zvi, Gil Ben-Zvi, Axel Himmelbach, Ron P MacLachlan, Andrew G Sharpe, Allan Fritz, Roi Ben-David, Hikmet Budak, Tzion Fahima, Abraham Korol, Justin D Faris, Alvaro Hernandez, Mark A Mikel, Avraham A Levy, Brian Steffenson, Marco Maccaferri, Roberto Tuberosa, Luigi Cattivelli, Primetta Faccioli, Aldo Ceriotti, Khalil Kashkush, Mohammad Pourkheirandish, Takao Komatsuda, Tamar Eilam, Hanan Sela, Amir Sharon, Nir Ohad, Daniel A Chamovitz, Klaus F X Mayer, Nils Stein, Gil Ronen, Zvi Peleg, Curtis J Pozniak, Eduard D Akhunov, Assaf Distelfeld
Wheat (Triticum spp.) is one of the founder crops that likely drove the Neolithic transition to sedentary agrarian societies in the Fertile Crescent more than 10,000 years ago. Identifying genetic modifications underlying wheat's domestication requires knowledge about the genome of its allo-tetraploid progenitor, wild emmer (T. turgidum ssp. dicoccoides). We report a 10.1-gigabase assembly of the 14 chromosomes of wild tetraploid wheat, as well as analyses of gene content, genome architecture, and genetic diversity...
July 7, 2017: Science
https://www.readbyqxmd.com/read/28676642/label-free-detection-of-sensitive-mid-infrared-biomarkers-of-glomerulonephritis-in-urine-using-fourier-transform-infrared-spectroscopy
#15
Mei-Ching Yu, Peter Rich, Liberty Foreman, Jennifer Smith, Mei-Shiuan Yu, Anisha Tanna, Vinod Dibbur, Robert Unwin, Frederick W K Tam
More reliable biomarkers using near-patient technologies are needed to improve early diagnosis and intervention for patients with renal disease. Infrared (IR) vibrational spectroscopy/microspectroscopy is an established analytical method that was first used in biomedical research over 20 years ago. With the advances in instrumentation, computational and mathematical techniques, this technology has now been applied to a variety of diseases; however, applications in nephrology are just beginning to emerge. In the present study, we used attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy to analyze urine samples collected from rodent models of inflammatory glomerulonephritis (GN) as well as from patients with crescentic GN, with the aim of identifying potential renal biomarkers; several characteristic mid-IR spectral markers were identified in urine samples...
July 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28674772/detection-of-unexpected-emergency-diseases-using-fdg-pet-ct-in-oncology-patients
#16
Akira Toriihara, Emi Yamaga, Masashi Nakadate, Jun Oyama, Ukihide Tateishi
PURPOSE: To evaluate the frequency of emergency diseases that were detected unexpectedly using FDG-PET/CT. MATERIALS AND METHODS: Interpretation reports for 11,663 FDG-PET/CT studies in our hospital were retrospectively reviewed. Patients with major emergency diseases were extracted according to the following exclusion criteria: (1) relevant findings had been recognized prior to the PET/CT; (2) an intervention or operation that may have been relevant to the present findings was performed within 1 month prior to the PET/CT; and (3) the clinical course could not be investigated sufficiently (e...
July 3, 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/28670084/medullary-angiitis-and-pauci-immune-crescentic-glomerulonephritis
#17
Jeffrey Klein, William Rodriguez, Michael Kuperman, Harold Szerlip
Although almost all pathological diagnoses made from a native kidney biopsy come from careful examination of the renal cortex, certain diseases have a characteristic medullary component. Medullary angiitis has histological features of interstitial hemorrhage in the medulla with an associated polymorphonuclear leukocyte infiltrate. These findings are primarily found in the setting of antineutrophil cytoplasmic antibody-associated vasculitis. Medullary angiitis identified in the setting of negative immunofluorescence is most suggestive of pauci-immune crescentic glomerulonephritis, as presented in this case...
July 2017: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/28669995/redefining-lupus-nephritis-clinical-implications-of-pathophysiologic-subtypes
#18
REVIEW
Feng Yu, Mark Haas, Richard Glassock, Ming-Hui Zhao
Systemic lupus erythematosus (SLE) is associated with a broad spectrum of clinical and immunologic manifestations, of which lupus nephritis is the most common cause of morbidity and mortality. The development of nephritis in patients with SLE involves multiple pathogenic pathways including aberrant apoptosis, autoantibody production, immune complex deposition and complement activation. The 2003 International Society of Nephrology/Renal Pathology Society (ISN/RPS) classification system for lupus nephritis was widely accepted with high intraobserver and interobserver concordance to guide therapeutic strategy and provide prognostic information...
August 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28667835/monocytes-promote-crescent-formation-in-anti-myeloperoxidase-antibody-induced-glomerulonephritis
#19
Anthony Rousselle, Ralph Kettritz, Adrian Schreiber
Neutrophils and monocytes express anti-neutrophil cytoplasmic antibody (ANCA) antigens, and activation of these cells by ANCA is central to ANCA-associated vasculitis and necrotizing crescentic glomerulonephritis (NCGN). The importance of neutrophils is established; however, any role of monocytes is less clear. We tested the hypothesis that depletion of CCR2(+) inflammatory monocytes and their derivatives would abrogate anti-myeloperoxidase (MPO) antibody-induced NCGN in a mouse model. We used passive anti-MPO antibody transfer for NCGN induction in wild-type mice or mice expressing the CCR2 promoter-controlled diphtheria toxin receptor...
June 28, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28667079/decreased-expression-of-connexin-43-blunts-the-progression-of-experimental-gn
#20
Panagiotis Kavvadas, Ahmed Abed, Coralie Poulain, Florence Authier, Lise-Paule Labéjof, Amelie Calmont, Carlo Afieri, Niki Prakoura, Jean-Claude Dussaule, Christos Chatziantoniou, Christos E Chadjichristos
GN refers to a variety of renal pathologies that often progress to ESRD, but the molecular mechanisms underlying this progression remain incompletely characterized. Here, we determined whether dysregulated expression of the gap junction protein connexin 43, which has been observed in the progression of renal disease, contributes to GN progression. Immunostaining revealed de novo expression of connexin 43 in damaged glomeruli in patients with glomerular diseases as well as in mice after induction of experimental GN...
June 30, 2017: Journal of the American Society of Nephrology: JASN
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