Mariana Margatto Rottini, Ana Claudia Fernandes Amaral, Jose Luiz Pinto Ferreira, Jefferson Rocha de Andrade Silva, Noemi Nosomi Taniwaki, Celeste da Silva Freitas de Souza, Luiz Ney d'Escoffier, Fernando Almeida-Souza, Daiana de Jesus Hardoim, Sylvio Celso Gonçalves da Costa, Kátia da Silva Calabrese
Current treatments for leishmaniasis present some difficulties due to their toxicity, the use of the intravenous route for administration and therapy duration, which may lead to treatment discontinuation. The aim of this study is to investigate new treatment alternatives to improve patients well being. Therefore, we evaluated the inhibitory effect of (-)α-bisabolol, a sesquiterpene alcohol found in various essential oils of different plant species, against the promastigotes and intracellular amastigotes forms of Leishmania amazonensis, as well as the cytotoxic, morphological and ultrastructural alterations of treated cells...
January 2015: Experimental Parasitology