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nosomial infection

Fernando Almeida-Souza, Celeste da Silva Freitas de Souza, Noemi Nosomi Taniwaki, João José Mendes Silva, Renata Mondêgo de Oliveira, Ana Lúcia Abreu-Silva, Kátia da Silva Calabrese
Leishmaniasis is a complex disease that is considered a serious public health problem. Due to the absence of an effective vaccine and debilitating chemotherapy better therapies are urgently needed. This situation has stimulated the search for alternative treatments such as the use of herbal medicines. Several studies conducted with Morinda citrifolia Linn. have shown various biological activities such as antitumor, immunomodulation and antileishmanial activity, however its mechanisms of action are still unknown...
August 31, 2016: Nitric Oxide: Biology and Chemistry
Sabrina Sayori Okada, Edson Mendes de Oliveira, Tomaz Henrique de Araújo, Maria Rita Rodrigues, Renata Chaves Albuquerque, Renato Arruda Mortara, Noemi Nosomi Taniwaki, Helder Imoto Nakaya, Ana Campa, Ana Carolina Ramos Moreno
Myeloperoxidase (MPO) is an important enzyme in the front-line protection against microorganisms. In peripheral blood, it is accepted that MPO is only produced by myeloid-lineage cells. Thus, MPO presence is unexpected in lymphocytes. We showed recently that B1-lymphocytes from mice have MPO. Here, we showed that subsets of human peripheral B, CD4(+) and CD8(+) T lymphocytes express MPO. The content of MPO in lymphocytes was very low compared to neutrophils/monocytes with a preferential distribution in the nucleus and perinuclear region...
February 2016: Cellular Immunology
Stephanie J Cole, Vincent T Lee
UNLABELLED: Bis-(3'-5') cyclic dimeric GMP (c-di-GMP) controls the lifestyle transition between the sessile and motile states in many Gram-negative bacteria, including the opportunistic human pathogen Pseudomonas aeruginosa. Under laboratory conditions, high concentrations of c-di-GMP decrease motility and promote biofilm formation, while low concentrations of c-di-GMP promote motility and decease biofilm formation. Here we sought to determine the contribution of c-di-GMP signaling to biofilm formation during P...
January 2016: Journal of Bacteriology
Antonio Sesso, Edite Hatsumi Yamashiro-Kanashiro, Noemia Mie Orii, Noemi Nosomi Taniwaki, Joyce Kawakami, Sylvia Mendes Carneiro
No abstract text is available yet for this article.
January 2015: Revista do Instituto de Medicina Tropical de São Paulo
Mariana Margatto Rottini, Ana Claudia Fernandes Amaral, Jose Luiz Pinto Ferreira, Jefferson Rocha de Andrade Silva, Noemi Nosomi Taniwaki, Celeste da Silva Freitas de Souza, Luiz Ney d'Escoffier, Fernando Almeida-Souza, Daiana de Jesus Hardoim, Sylvio Celso Gonçalves da Costa, Kátia da Silva Calabrese
Current treatments for leishmaniasis present some difficulties due to their toxicity, the use of the intravenous route for administration and therapy duration, which may lead to treatment discontinuation. The aim of this study is to investigate new treatment alternatives to improve patients well being. Therefore, we evaluated the inhibitory effect of (-)α-bisabolol, a sesquiterpene alcohol found in various essential oils of different plant species, against the promastigotes and intracellular amastigotes forms of Leishmania amazonensis, as well as the cytotoxic, morphological and ultrastructural alterations of treated cells...
January 2015: Experimental Parasitology
Noemi Nosomi Taniwaki, Viviane Martinelli Gonçalves, Julianna Kesselring Romero, Claudio Vieira da Silva, Solange da Silva, Renato Arruda Mortara
An experimental model for chronic Chagas disease was developed to investigate whether reactivation is influenced by the genetic origin of Trypanosoma cruzi isolates. In addition, we examined whether the distribution of T. cruzi stage-specific epitopes, as defined by monoclonal antibodies (Mab), raised against mammalian-stage parasite forms, exhibited comparable distribution patterns in Calomys callosus myocardium during the acute phase and after reactivation of the infection. Animals were infected with parasites of the G (T...
August 2011: Parasitology Research
Antonio José Sáez-Castillo, María José Olmo-Jiménez, José María Pérez Sánchez, Miguel Angel Negrín Hernández, Angel Arcos-Navarro, Juan Díaz-Oller
OBJECTIVE: Nosocomial infection is one of the main causes of morbidity and mortality in patients admitted to hospital. One aim of this study is to determine its intrinsic and extrinsic risk factors. Nosocomial infection also increases the duration of hospital stay. We quantify, in relative terms, the increased duration of the hospital stay when a patient has the infection. METHODS: We propose the use of logistic regression models with an asymmetric link to estimate the probability of a patient suffering a nosocomial infection...
June 2010: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
R Lodinová-Zádníková, L Prokesová, H Tlaskalová, I Kocourková, J Zizka, Z Stranák
OBJECTIVE: prevention of repeated infections and allergies in children of allergic mothers by oral colonization with probiotic E. coli strain.The development of some immunologic parameters. Long - term studies. DESIGN: Original contribution SETTING: Mother and Child Care Institute of Prague. METHODS AND RESULTS: The results of our long-term studies confirmed that orally administered probiotic E. coli strain after birth rapidly colonized the gastrontestinal tract of the newborn and remained dominant for many weeks...
December 2004: Ceská Gynekologie
Anna S Levin, Carlos E Levy, A Edison I Manrique, Eduardo A S Medeiros, Silvia F Costa
Forty consecutive patients with nosomial infections caused by multidrug-resistant Acinetobacter baumannii were treated with intravenous ampicillin/sulbactam. The infections were primary bloodstream (32.5%), pneumonia (30%), urinary tract (15%), peritonitis (7.5%), surgical site (7.5%), meningitis (5%) and sinusitis (2.5%). Most were severe infections with underlying conditions (median APACHE II score: 14.5) and 72.5% occurred in the ICU. Twenty-seven (67.5%) were improved/cured, seven (17.5%) were failures and six (15%) were considered to have an indeterminate outcome because patients died within the first 48 h of treatment...
January 2003: International Journal of Antimicrobial Agents
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