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https://www.readbyqxmd.com/read/29332122/quantitative-study-of-the-macular-microvasculature-in-human-donor-eyes
#1
Paula K Yu, Zaid Mammo, Chandrakumar Balaratnasingam, Dao-Yi Yu
Purpose: To precisely quantify the macular microvasculature density using microperfusion and labeling techniques in human donor eyes. Such information may be useful in understanding the role of the macular microvasculature in coping with the metabolic requirements of the neurons in this densely packed region, and provide a reference point for clinical studies using recently developed optical imaging techniques. Methods: The macular microvasculature was perfusion-labeled in 18 human donor eyes and optical stacks collected from regions superior, temporal, inferior, and nasal to the foveola using confocal microscopy...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29329056/subjective-and-objective-sleep-discrepancy-in-symptomatic-bipolar-disorder-compared-to-healthy-controls
#2
Venkatesh Krishnamurthy, Dahlia Mukherjee, Aubrey Reider, Scott Seaman, Gagan Singh, Julio Fernandez-Mendoza, Erika Saunders
BACKGROUND: Bipolar disorder (BD) is associated with sleep misperception. The objective of this study was to investigate the correlation between subjective and objective measures of sleep in persons with symptomatic bipolar disorder (BDS) compared to healthy controls (HC). METHODS: We studied 24 BDS and 30 HC subjects similar in age, race and sex. Subjective sleep was measured with Pittsburgh Sleep Quality Index (PSQI) and objective sleep with 7-days of actigraphy...
January 3, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29328977/skin-lightening-practices-among-female-high-school-students-in-ghana
#3
M Osei, M Ali, A Owusu, F Baiden
OBJECTIVE: The practice of skin lightening (SL) persist despite warnings about its harmful health effects. Adolescents are particularly vulnerable and at risk of prolonged use of SL products. We explored SL practices among high school students in Ghana, West Africa. STUDY DESIGN: Cross-sectional survey. METHODS: We used a self-administered questionnaire in a survey on SL practices among randomly selected female students in five Senior High Schools in the Brong Ahafo Region of Ghana...
January 9, 2018: Public Health
https://www.readbyqxmd.com/read/29328176/ultra-sensitive-quasi-distributed-temperature-sensor-based-on-an-apodized-fiber-bragg-grating
#4
Nazmi A Mohammed, Hatem O El Serafy
This work targets a remarkable quasi-distributed temperature sensor based on an apodized fiber Bragg grating. To achieve this, the mathematical formula for a proposed apodization function is carried out and tested. Then, an optimization parametric process required to achieve the remarkable accuracy that is based on coupled mode theory (CMT) is done. A detailed investigation for the side lobe analysis, which is a primary judgment factor, especially in quasi-distributed configuration, is investigated. A comparison between elite selection of apodization profiles (extracted from related literatures) and the proposed modified-Nuttal profile is carried out covering reflectivity peak, full width half maximum (FWHM), and side lobe analysis...
January 10, 2018: Applied Optics
https://www.readbyqxmd.com/read/29327646/late-blight-resistance-screening-of-major-wild-swedish-solanum-species-s-dulcamara-s-nigrum-and-s-physalifolium
#5
Kibrom Abreha, Åsa Lankinen, Laura Masini, Sofia Hydbom, Erik Andreasson
To understand the contribution of wild Solanum species to the epidemiology of potato late blight in Sweden, we characterized the resistance of the three putative alternative hosts; Solanum physalifolium, S. nigrum, and S. dulcamara to Phytophthora infestans, the causal agent of late blight. The pathogen sporulated in all ten investigated S. physalifolium genotypes, suggesting susceptibility (S phenotype). Field-grown S. physalifolium was naturally infected but could regrow, though highly infected genotypes were smaller at the end of the season...
January 12, 2018: Phytopathology
https://www.readbyqxmd.com/read/29325392/horizontal-localization-in-simulated-unilateral-hearing-loss
#6
Anvarsamarein Parisa, Nazeri Ahmad Reza, Sameni Seyyed Jalal, Kamali Mohammad, Zarrin Koob Homa
BACKGROUND AND OBJECTIVES: The ability to localize a sound source is one of the binaural hearing benefits in a horizontal plane based on interaural time difference and interaural intensity difference. Unilateral or bilateral asymmetric hearing loss will affect binaural hearing and lead to sound locating errors. In this cross sectional analytical descriptive study, the localization error was investigated when participants turned their heads to the sound source with closed eyes and after simulating unilateral hearing loss by placing earplugs inside the right ear canal...
December 2017: Journal of Audiology & Otology
https://www.readbyqxmd.com/read/29325120/strigolactone-biosynthesis-genes-of-rice-is-required-for-the-punctual-entry-of-arbuscular-mycorrhizal-fungi-into-the-roots
#7
Yoshihiro Kobae, Hiromu Kameoka, Yusaku Sugimura, Katsuharu Saito, Ryo Ohtomo, Toru Fujiwara, Junko Kyozuka
Arbuscular mycorrhiza (AM) is a mutualistic association between most plant species and the ancient fungal phylum Glomeromycota in roots, and it plays a key role in a plant's nutrient uptake from the soil. Roots synthesize strigolactones (SLs), derivatives of carotenoids, and exude them to induce energy metabolism and hyphal branching of AM fungi. Despite the well-documented roles of SLs in the presymbiotic phase, little is known about the role of SLs in the process of root colonization. Here we show that the expansion of root colonization is suppressed in the mutants of rice (Oryza sativa) SL biosynthesis genes, carotenoid cleavage dioxygenase D10 and more severely in D17...
January 9, 2018: Plant & Cell Physiology
https://www.readbyqxmd.com/read/29322267/association-of-decision-making-in-spinal-surgery-with-specialty-and-emotional-involvement-the-indications-in-spinal-surgery-indiana-survey
#8
Nico Sollmann, Carmen Morandell, Lucia Albers, Michael Behr, Alexander Preuss, Andreas Dinkel, Bernhard Meyer, Sandro M Krieg
BACKGROUND: Although recent trials provided level I evidence for the most common degenerative lumbar spinal disorders, treatment still varies widely. Thus, the Indications in Spinal Surgery (INDIANA) survey explores whether decision-making is influenced by specialty or personal emotional involvement of the treating specialist. METHOD: Nationwide, neurosurgeons and orthopedic surgeons specialized in spine surgery were asked to answer an Internet-based questionnaire with typical clinical patient cases of lumbar disc herniation (DH), lumbar spinal stenosis (SS), and lumbar degenerative spondylolisthesis (SL)...
January 10, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29321007/staging-laparoscopy-for-locally-advanced-gastric-cancer-in-chinese-patients-a-multicenter-prospective-registry-study
#9
Ziyu Li, Zhemin Li, Lianhai Zhang, Qian Liu, Zhenjun Wang, Zhongtao Zhang, Gang Xiao, Wei Fu, Xin Wang, Yingjiang Ye, Jianchun Yu, Fei Li, Lin Chen, Shibin Wang, Jiafu Ji
BACKGROUND: Staging laparoscopy(SL) is a recommended technique for the staging of Gastric Cancer(GC) and provides the indication for a radical surgery. Considering the medical practice in China, the standardized and regular usage of SL is yet to be spread. However, existing guidelines vary and make an ambiguity of indication for SL. Besides, the specific indication for Chinese patients remains a niche. This study aims to the essential, missing information of Chinese patients and tries to normalize the indication of LS in medical practice in China...
January 10, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29320948/the-profiles-of-soluble-adhesion-molecules-in-the-great-obstetrical-syndromes
#10
Nikolina Docheva, Roberto Romero, Piya Chaemsaithong, Adi L Tarca, Gaurav Bhatti, Percy Pacora, Bogdan Panaitescu, Noppadol Chaiyasit, Tinnakorn Chaiworapongsa, Eli Maymon, Sonia S Hassan, Offer Erez
OBJECTIVE: The objective of this study was to determine the profiles of maternal plasma soluble adhesion molecules in patients with preeclampsia, small-for-gestational-age (SGA) fetuses, acute pyelonephritis, preterm labor with intact membranes (PTL), preterm prelabor rupture of the membranes (preterm PROM), and fetal death. MATERIALS AND METHODS: A cross-sectional study was conducted to determine maternal plasma concentrations of sE-selectin, sL-selectin, and sP-selectin as well as sICAM-1, sVCAM-1, and sPECAM-1 in patients with 1) an uncomplicated pregnancy (control, n = 100); 2) preeclampsia (n = 94); 3) SGA fetuses (in women without preeclampsia/hypertension, n = 45); 4) acute pyelonephritis (n = 25); 5) PTL (n = 53); 6) preterm PROM (n = 24); and 7) fetal death (n = 34)...
January 10, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29318875/a-polycapillary-optics-based-confocal-micro-xrf-and-xas-setup-at-esrf-crg-beamline-dubble-bm26a
#11
Stephen Bauters, Pieter Tack, Jennifer Helen Rudloff-Grund, Dipanjan Banerjee, Alessandro Longo, Bart Vekemans, Wim Bras, Frank E Brenker, Roelof van Silfhout, Laszlo Vincze
A novel plug-and-play setup based on polycapillary X-ray optics enables 3D confocal XRF and XAS down to 8×8×11 µm3 (17 keV) at the ESRF CRG beamline DUBBLE, BM26A. A complete description and analytical characterization is presented, together with 2 recently performed experimental cases. In Deep Earth diamond SL-FFM 16, an Olivine rich inclusion was mapped with full 3D XRF elemental imaging. The preliminary tests on an Iron Gall ink containing historical document, a letter from the court of King Philip II of Spain, reveals both the delicate nature of Iron Gall ink and the lack of Fe-Ni chemical bonding...
January 10, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29317049/autoimmunity-against-a-glycolytic-enzyme-as-a-possible-cause-for-persistent-symptoms-in-lyme-disease
#12
Paolo Maccallini, Serena Bonin, Giusto Trevisan
Some patients with a history of Borrelia burgdorferi infection develop a chronic symptomatology characterized by cognitive deficits, fatigue, and pain, despite antibiotic treatment. The pathogenic mechanism that underlines this condition, referred to as post-treatment Lyme disease syndrome (PTLDS), is currently unknown. A debate exists about whether PTLDS is due to persistent infection or to post-infectious damages in the immune system and the nervous system. We present the case of a patient with evidence of exposure to Borrelia burgdorferi sl and a long history of debilitating fatigue, cognitive abnormalities and autonomic nervous system issues...
January 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29305391/prevalence-and-risk-factors-for-microcephaly-at-birth-in-brazil-in-2010
#13
Antônio A Silva, Marco A Barbieri, Maria T Alves, Carolina A Carvalho, Rosângela F Batista, Marizélia R Ribeiro, Fernando Lamy-Filho, Zeni C Lamy, Viviane C Cardoso, Ricardo C Cavalli, Vanda M Simões, Heloisa Bettiol
OBJECTIVES: To estimate the baseline prevalence and risk factors for microcephaly at birth before the Zika virus epidemic in 2 Brazilian cities. METHODS: We used population-based data from the Brazilian Ribeirão Preto (RP) and São Luís (SL) birth cohort studies of 2010 that included hospital deliveries by resident mothers. The final sample was 7376 live births in RP and 4220 in SL. Gestational age was based on the date of the mother's last normal menstrual period or obstetric ultrasonography, if available...
January 5, 2018: Pediatrics
https://www.readbyqxmd.com/read/29303855/review-of-readiness-of-us-general-surgery-residents-for-independent-practice-by-george-bc-bohnen-jd-williams-rg-meyerson-sl-schuller-mc-clark-mj-meier-ah-torbeck-l-mandell-sp-mullen-jt-smink-ds-scully-re-chipman-jg-auyang-ed-terhune-kp-wise-pe-choi-jn-foley
#14
https://www.readbyqxmd.com/read/29301044/remote-monitoring-of-dynamic-canopy-photosynthesis-with-high-time-resolution-light-induced-fluorescence-transients
#15
Rhys Wyber, Barry Osmond, Michael B Ashcroft, Zbynek Malenovský, Sharon A Robinson
Understanding the net photosynthesis of plant canopies requires quantifying photosynthesis in challenging environments, principally due to the variable light intensities and qualities generated by sunlight interactions with clouds and surrounding foliage. The dynamics of sunflecks and rates of change in light intensity at the beginning and end of sustained light (SL) events makes photosynthetic measurements difficult, especially when dealing with less accessible parts of plant foliage. High time resolved photosynthetic monitoring from pulse amplitude modulated (PAM) fluorometers has limited applicability due to the invasive nature of frequently applied saturating flashes...
December 28, 2017: Tree Physiology
https://www.readbyqxmd.com/read/29300919/methyl-phenlactonoates-are-efficient-strigolactone-analogs-with-simple-structure
#16
Muhammad Jamil, Boubacar A Kountche, Imran Haider, Xiujie Guo, Valentine O Ntui, Kun-Peng Jia, Shawkat Ali, Umar S Hameed, Hidemitsu Nakamura, Ying Lyu, Kai Jiang, Kei Hirabayashi, Masaru Tanokura, Stefan T Arold, Tadao Asami, Salim Al-Babili
Strigolactones (SLs) are a new class of phytohormones that also act as germination stimulants for root parasitic plants, such as Striga spp., and as branching factors for symbiotic arbuscular mycorrhizal fungi. Sources for natural SLs are very limited. Hence, efficient and simple SL analogs are needed for elucidating SL-related biological processes as well as for agricultural applications. Based on the structure of the non-canonical SL methyl carlactonoate, we developed a new, easy to synthesize series of analogs, termed methyl phenlactonoates (MPs), evaluated their efficacy in exerting different SL functions, and determined their affinity for SL receptors from rice and Striga hermonthica...
December 28, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29300844/link-synthetic-lethality-to-drug-sensitivity-of-cancer-cells
#17
Ruiping Wang, Yue Han, Zhangxiang Zhao, Fan Yang, Tingting Chen, Wenbin Zhou, Xianlong Wang, Lishuang Qi, Wenyuan Zhao, Zheng Guo, Yunyan Gu
Synthetic lethal (SL) interactions occur when alterations in two genes lead to cell death but alteration in only one of them is not lethal. SL interactions provide a new strategy for molecular-targeted cancer therapy. Currently, there are few drugs targeting SL interactions that entered into clinical trials. Therefore, it is necessary to investigate the link between SL interactions and drug sensitivity of cancer cells systematically for drug development purpose. We identified SL interactions by integrating the high-throughput data from The Cancer Genome Atlas, small hairpin RNA data and genetic interactions of yeast...
December 28, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/29298836/at-mini-zinc-finger2-and-sl-inhibitor-of-meristem-activity-a-conserved-missing-link-in-the-regulation-of-floral-meristem-termination-in-arabidopsis-and-tomato
#18
Norbert Bollier, Adrien Sicard, Julie Leblond-Castaing, David Latrasse, Nathalie Gonzalez, Frédéric Gévaudant, Moussa Benhamed, Cécile Raynaud, Michael Lenhard, Christian Chevalier, Michel Hernould, Frédéric Delmas
In angiosperms, the gynoecium is the last structure to develop within the flower due to the determinate fate of floral meristem (FM) stem cells. The maintenance of stem cell activity before its arrest at the stage called FM termination affects the number of carpels that develop. The necessary inhibition at this stage of WUSCHEL (WUS), which is responsible for stem cell maintenance, involves a two-step mechanism. Direct repression mediated by the MADS-domain transcription factor AGAMOUS (AG), followed by indirect repression requiring the C2H2 zinc-finger protein KNUCKLES (KNU), allow for the complete termination of floral stem cell activity...
January 3, 2018: Plant Cell
https://www.readbyqxmd.com/read/29297205/cyclophosphamide-for-connective-tissue-disease-associated-interstitial-lung-disease
#19
REVIEW
Hayley Barnes, Anne E Holland, Glen P Westall, Nicole Sl Goh, Ian N Glaspole
BACKGROUND: Approximately one-third of individuals with interstitial lung disease (ILD) have associated connective tissue disease (CTD). The connective tissue disorders most commonly associated with ILD include scleroderma/systemic sclerosis (SSc), rheumatoid arthritis, polymyositis/dermatomyositis, and Sjögren's syndrome. Although many people with CTD-ILD do not develop progressive lung disease, a significant proportion do progress, leading to reduced physical function, decreased quality of life, and death...
January 3, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29289470/prostanoid-dependent-bladder-pain-caused-by-proteinase-activated-receptor-2-activation-in-mice-involvement-of-trpv1-and-t-type-ca2-channels
#20
Maho Tsubota, Tomoka Ozaki, Yuko Hayashi, Yasumasa Okawa, Ayaka Fujimura, Fumiko Sekiguchi, Hiroyuki Nishikawa, Atsufumi Kawabata
We studied the pronociceptive role of proteinase-activated receptor-2 (PAR2) in mouse bladder. In female mice, intravesical infusion of the PAR2-activating peptide, SLIGRL-amide (SL), caused delayed mechanical hypersensitivity in the lower abdomen, namely 'referred hyperalgesia', 6-24 h after the administration. The PAR2-triggered referred hyperalgesia was prevented by indomethacin or a selective TRPV1 blocker, and restored by a T-type Ca2+ channel blocker. In human urothelial T24 cells, SL caused delayed prostaglandin E2 production and COX-2 upregulation...
December 15, 2017: Journal of Pharmacological Sciences
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