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Ahmad Alobeid, Tarek El-Bialy, Susanne Reimann, Ludger Keilig, Dirk Cornelius, Andreas Jäger, Christoph Bourauel
Background/objective: The aim of this study was to evaluate the efficacy of tooth alignment with conventional and self-ligating labial and lingual orthodontic bracket systems. Materials/methods: We tested labial brackets (0.022″ slot size) and lingual brackets (0.018″ slot size). The labial brackets were: (i) regular twin brackets (GAC-Twin [Dentsply]), (ii) passive self-ligating brackets including (Damon-Q® [ORMCO]; Ortho classic H4™ [Orthoclassic]; FLI®SL [RMO]), and (iii) active self-ligating brackets (GAC In-Ovation®C [DENTSPLY] and SPEED™[Strite])...
March 13, 2018: European Journal of Orthodontics
Suhong Xiao, Ying-Sheng Tang, Praveen Kusumanchi, Sally P Stabler, Ying Zhang, Asok C Antony
Background: Epidemiologic and in vitro studies suggest independent linkages between poor folate and/or vitamin B-12 nutrition, genomic human papillomavirus (HPV) type 16 viral integration, and cancer. However, there is no direct evidence in vivo to support the causative role of poor folate nutrition in HPV16 integration into the cellular genome. Objective: We tested the hypothesis that folate deficiency enables the integration of HPV16 into the genome of HPV16-harboring keratinocytes, and could thereby influence earlier transformation of these cells to cancer in an animal model...
March 1, 2018: Journal of Nutrition
Renping Liu, Peihong Wang, Caiqing Wu, Juan Chen, Chengxin Li, Yongtao Xie, Qi Wang, Jianming Liu, Huan He, Jing Zhu
Hedyotis diffusa Willd (HDW) is a constituent of several Chinese medicines used clinically to treat inflammatory diseases, including airway inflammation. The aim of the present study was to investigate whether HDW serves a protective role in suppressing chronic airway inflammation and its underlying mechanisms. A mouse model of chronic smoking was induced via exposure to cigarette smoke (CS) for 30 days, increasing the exposure time for up to 5 min per day and the administration of lipopolysaccharide (LPS)...
April 2018: Experimental and Therapeutic Medicine
Ron Stauder, Ralf Welsch, Maurizio Camagna, Wouter Kohlen, Gerd U Balcke, Alain Tissier, Michael H Walter
Strigolactones (SLs) are apocarotenoid phytohormones synthesized from carotenoid precursors. They are produced most abundantly in roots for exudation into the rhizosphere to cope with mineral nutrient starvation through support of root symbionts. Abscisic acid (ABA) is another apocarotenoid phytohormone synthesized in roots, which is involved in responses to abiotic stress. Typically low carotenoid levels in roots raise the issue of precursor supply for the biosynthesis of these two apocarotenoids in this organ...
2018: Frontiers in Plant Science
Naoki Ohno, Tosiaki Miyati, Shuto Suzuki, Hirohito Kan, Toshitaka Aoki, Yoshitaka Nakamura, Yuki Hiramatsu, Satoshi Kobayashi, Toshifumi Gabata
PURPOSE: To suppress olefinic signals and enable simultaneous and quantitative estimation of multiple functional parameters associated with water and lipid, we investigated a modified method using chemical shift displacement and recovery-based separation of lipid tissue (SPLIT) involving acquisitions with different inversion times (TIs), echo times (TEs), and b-values. MATERIALS AND METHODS: Single-shot diffusion echo-planar imaging (SSD-EPI) with multiple b-values (0-3000 s/mm2 ) was performed without fat suppression to separate water and lipid images using the chemical shift displacement of lipid signals in the phase-encoding direction...
March 12, 2018: Magnetic Resonance Imaging
Memi Muto, Wataru Kamitani, Mizuki Sakai, Minato Hirano, Shintaro Kobayashi, Hiroaki Kariwa, Kentaro Yoshii
Tick-borne encephalitis virus (TBEV) causes severe neurological disease, but the pathogenetic mechanism is unclear. The conformational structure of the 3'-untranslated region (UTR) of TBEV is associated with its virulence. We tried to identify host proteins interacting with the 3'-UTR of TBEV. Cellular proteins of HEK293T cells were co-precipitated with biotinylated RNAs of the 3'-UTR of low- and high-virulence TBEV strains and subjected to mass spectrometry analysis. Fifteen host proteins were found to bind to the 3'-UTR of TBEV, four of which- cold shock domain containing-E1 (CSDE1), spermatid perinuclear RNA binding protein (STRBP), fragile X mental retardation protein (FMRP), and interleukin enhancer binding factor 3 (ILF3)-bound specifically to that of the low-virulence strain...
March 12, 2018: Virus Research
Oneida Espinosa-Álvarez, Paola A Ortiz, Luciana Lima, André G Costa-Martins, Myrna G Serrano, Stephane Herder, Gregory A Buck, Erney P Camargo, Patrick B Hamilton, Jamie R Stevens, Marta M G Teixeira
Trypanosoma rangeli and Trypanosoma cruzi are generalist trypanosomes sharing a wide range of mammalian hosts; they are transmitted by triatomine bugs, and are the only trypanosomes infecting humans in the Neotropics. Their origins, phylogenetic relationships, and emergence as human parasites have long been subjects of interest. In the present study, taxon-rich analyses (20 trypanosome species from bats and terrestrial mammals) using ssrRNA, glycosomal glyceraldehyde-3-phosphate dehydrogenase (gGAPDH), heat shock protein-70 (HSP70) and Spliced Leader (SL) RNA sequences, and multilocus phylogenetic analyses using 11 single copy genes from 15 selected trypanosomes, provide increased resolution of relationships between species and clades, strongly supporting two main sister lineages: lineage Schizotrypanum, comprising T...
March 12, 2018: International Journal for Parasitology
Billy T Hulin, Tim J Gabbett, Rich D Johnston, David G Jenkins
PURPOSE: Determine: 1) how change of direction (COD) workloads influence PlayerLoad variables when controlling total distance covered, and 2) relationships among collision workloads and PlayerLoad variables during rugby league match-play. METHODS: Participants completed 3 protocols (crossover design) consisting of 10 repetitions of a 60 m effort in 15 s. The difference between each protocol was the COD demands required to complete 1 repetition; no COD (SL), 1 x 180º COD (1COD), or 3 x 180º COD (3COD)...
March 15, 2018: International Journal of Sports Physiology and Performance
Semin Ryu, Dongbum Pyo, Soo-Chul Lim, Dong-Soo Kwon
Recently, various methods using, simultaneously, two types of tactile feedback have been proposed to emulate a real object. However, the possible masking effect when providing two types of tactile feedback has been scarcely reported. In this study, we investigated the masking effect caused by mechanical vibration on the perception of electrovibration. The absolute and difference thresholds of the electrovibration were measured according to the presence/absence, frequency, and intensity of the mechanical vibration...
March 14, 2018: Scientific Reports
Taraka Ramji Moturu, Sravan Kumar Thula, Ravi Kumar Singh, Tomasz Nodzynski, Radka Svobodová Vareková, Jirí Friml, Sibu Simon
Strigolactones (SLs) are relatively recent addition to plant hormones that reported to control different aspects of plant development. SL signalling is perceived by an α/β hydrolase DWARF 14 (D14). A close homologue of D14, KARRIKIN INSENSTIVE2 (KAI2) involved in perception of an uncharacterized molecule called Karrikin (KR). Recent studies identified the SUPPRESSOR OF MAX2 1 (SMAX1) and SMXL7 in Arabidopsis to be potential SCF-MAX2 complex mediated proteasome targets of KAI2 and D14 respectively. Genetic studies on SMXL7 and SMAX1 demonstrated distinct developmental roles of each but very little sequence features are known about these repressors...
March 10, 2018: Journal of Experimental Botany
Imran Haider, Beatriz Andreo-Jimenez, Mark Bruno, Andrea Bimbo, Kristýna Floková, Haneen Abuauf, Valentine Otang Ntui, Xiujie Guo, Tatsiana Charnikhova, Salim Al-Babili, Harro J Bouwmeester, Carolien Ruyter-Spira
Both strigolactones (SLs) and abscisic acid (ABA) biosynthetically originate from carotenoids. Considering their common origin, the interaction of these two hormones at the biosynthetic and/or regulatory level may be anticipated. Here, we show in rice that drought simultaneously induces SL production in the root, and ABA production and the expression of SL biosynthetic genes in the shoot. Under control conditions, the ABA concentration was higher in shoots of the SL biosynthetic rice mutants dwarf10 (d10) and d17 than in wild-type plants, while a similar trend was observed for SL-perception mutant d3...
March 10, 2018: Journal of Experimental Botany
Sumit Agrawal, Nadine Schart-Morén, Wei Liu, Hanif M Ladak, Helge Rask-Andersen, Hao Li
OBJECTIVE: We used synchrotron radiation phase contrast imaging (SR-PCI) to study the 3D microanatomy of the basilar membrane (BM) and its attachment to the spiral ligament (SL) (with a conceivable secondary spiral lamina [SSL] or secondary spiral plate) at the round window membrane (RWM) in the human cochlea. The conception of this complex anatomy may be essential for accomplishing structural preservation at cochlear implant surgery. MATERIAL AND METHODS: Sixteen freshly fixed human temporal bones were used to reproduce the BM, SL, primary and secondary osseous spiral laminae (OSL), and RWM using volume-rendering software...
March 14, 2018: Upsala Journal of Medical Sciences
Rubens Spin-Neto, Louise H Matzen, Lars W Schropp, Thomas S Sørensen, Ann Wenzel
OBJECTIVES: To assess the impact of head motion artefacts and an automated artefact-correction system on CBCT image quality and interpretability for simulated diagnostic tasks. METHODS: A partially dentate human skull was mounted on a robot simulating four types of head movement (antero-posterior translation, nodding, lateral rotation, and tremor), at three distances (0.75, 1.5, and 3 mm) based on two movement patterns (skull returning/not returning to the initial position)...
March 14, 2018: Dento Maxillo Facial Radiology
Santiago Celaya González, Daniel Rábago Gómez, Ismael Fuente Merino, Luis Quindós López, Núria Bon Carreras, María Trinidad Valero Castell, José Luis Gutierrez Villanueva, Carlos Sainz Fernández
Radon-222, a naturally occurring radioactive gas, responsible together with its progeny of around 50% of the average effective dose received by the population, has not been regulated by law until the recent Directive 2013/51 /Euratom. Its transposition into Spanish legislation was made in the recent RD 314/2016, which sets at limit value of 500 Bq l-1 for radon-222 in water for human consumption. Intercomparison exercises, such as those carried out by IPROMA SL and the Laboratory of Environmental Radioactivity of the Cantabria University (LARUC) in November 2015 and December 2016, represent the most useful tool available for detecting problems and taking corrective actions necessary for an efficient measurement by part of the laboratories...
March 9, 2018: Radiation Protection Dosimetry
Yuan Liu, Lars Ojamäe
In contrast to the rich knowledge of water and 17 experimentally confirmed crystalline phases of solid water under positive pressures, water under negative pressure has been poorly explored. In this study, a new crystalline phase of ice with ultralow density (0.6 g cm-3 ), named "clathrate ice sL", is constructed by nano water cage clusters, and it is predicted to be stable under a lower negative pressure than the experimentally confirmed sII phase by first-principles phase diagram computations, thereby extending the phase diagram of water to negative pressure regions below -5170 bar at 0 K and below -4761 bar at 300 K...
March 13, 2018: Physical Chemistry Chemical Physics: PCCP
Gijs A Looijen, Bobby K Pranger, Koert P de Jong, Jan Pieter Pennings, Vincent E de Meijer, Joris I Erdmann
BACKGROUND: This study aimed to evaluate the additional value of laparoscopic ultrasound (LUS) to staging laparoscopy (SL) for detecting occult liver metastases in patients with potentially resectable pancreatic head cancer. METHODS: A retrospective cohort study was performed including all patients who underwent SL and LUS between 2005 and 2016. LUS was performed during SL to detect liver metastases not found by preoperative imaging or visual inspection of the liver...
March 12, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
Bethany L Hansberger, Shellie Acocello, Lindsay V Slater, Joseph M Hart, Jatin P Ambegaonkar
CONTEXT:   Anterior cruciate ligament (ACL) injuries often occur during jump landings and can have detrimental short-term and long-term functional effects on quality of life. Despite frequently performing jump landings, dancers have lower incidence rates of ACL injury than other jump-landing athletes. Planned versus unplanned activities and footwear may explain differing ACL-injury rates among dancers and nondancers. Still, few researchers have compared landing biomechanics between dancers and nondancers...
March 12, 2018: Journal of Athletic Training
Masaaki Konishi, Tomotake Morita, Tokuma Fukuoka, Tomohiro Imura, Shingo Uemura, Hiroyuki Iwabuchi, Dai Kitamoto
We discovered that Candida floricola ZM1502 is capable of selectively producing the promising hydrophilic biosurfactants, acid-form sophorolipids (SLs), from glycerol. However, productivity was very low (approximately 3.5 g L-1 ) under the initial culture conditions. Here, we describe the design of culture medium for abundant production of acid-form SLs by C. floricola ZM1502 using waste glycerol and hydrophobic substrates in order to develop a method for SL production and disposal of waste glycerol produced by oleo-chemical industries...
March 9, 2018: Journal of Oleo Science
Cyril Hamiaux, Revel S M Drummond, Zhiwei Luo, Hui Wen Lee, Prachi Sharma, Bart J Janssen, Nigel B Perry, William A Denny, Kimberley C Snowden
The strigolactone (SL) family of plant hormones regulates a broad range of physiological processes affecting plant growth and development and also plays essential roles in controlling interactions with parasitic weeds and symbiotic fungi. Recent progress elucidating details of SL biosynthesis, signalling, and transport offer many opportunities for discovering new plant growth regulators via chemical interference. Here, using high throughput screening and downstream biochemical assays, we identified N -phenylanthranilic acid derivatives as potent inhibitors of the SL receptors from petunia (DAD2), rice (OsD14) and Arabidopsis (AtD14)...
March 9, 2018: Journal of Biological Chemistry
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