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https://www.readbyqxmd.com/read/27913457/treatment-of-blastic-plasmacytoid-dendritic-cell-neoplasm
#1
Jill M Sullivan, David A Rizzieri
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare myeloid malignancy with no defined standard of care. BPDCN presents most commonly with skin lesions with or without extramedullary organ involvement before leukemic dissemination. As a result of its clinical ambiguity, differentiating BPDCN from benign skin lesions or those of acute myeloid leukemia with leukemia cutis is challenging. BPDCN is most easily defined by the phenotype CD4(+)CD56(+)CD123(+)lineage(-)MPO(-), although many patients will present with variable expression of CD4, CD56, or alternate plasmacytoid markers, which compounds the difficulty in differentiating BPDCN from other myeloid or lymphoid malignancies...
December 2, 2016: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/27912111/can-ictal-meg-obviate-the-need-for-phase-ii-monitoring-in-people-with-drug-refractory-epilepsy-a-prospective-observational-study
#2
Bhargavi Ramanujam, Kamal Bharti, Vibhin Viswanathan, Ajay Garg, Madhavi Tripathi, Chandrashekhar Bal, P Sarat Chandra, Manjari Tripathi
PURPOSE: To determine if ictal-magnetoencephalography (ictal-MEG) source localization (SL) added information towards delineating the ictal-onset zone (IOZ), whether and how it helped final decision-making in epilepsy-surgery. METHODS: Definite focal clusters on ictal-MEG were available for 32 DRE-patients, data was analyzed (single equivalent current dipole (ECD) model), SL done. Clinical history, long-term video-EEG (VEEG) monitoring, epilepsy-protocol MRI, FDG-PET, ictal-SPECT and interictal-MEG were discussed at the multispeciality Epilepsy Surgery Case-conference (ESC)...
October 31, 2016: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/27909790/strigolactones-affect-tomato-hormone-profile-and-somatic-embryogenesis
#3
Yuanli Wu, Evgenia Dor, Joseph Hershenhorn
Exogenously applied GR24 affected somatic embryo formation and morphogenesis of strigolactone-deficient tomato mutant through cross-talk with auxins and cytokinins indicating involvement of SLs in the embryogenic process. Strigolactones (SLs) mediate the regulation of plant responses to the environment through cross-talk with other plant hormones, especially auxins. Auxins play a crucial role in coordinating the morphogenesis and development of plant reproductive organs, including the signal-transduction cascade leading to the reprogramming of gene-expression patterns before embryo formation...
December 1, 2016: Planta
https://www.readbyqxmd.com/read/27908687/fertility-response-evaluation-of-artificial-insemination-methods-in-sheep-with-fresh-and-frozen-thawed-semen
#4
Reza Masoudi, Ahmad Zare Shahneh, Armin Towhidi, Hamid Kohram, Abbas Akbarisharif, Mohsen Sharafi
The aim of this study was to evaluate the fertility response of artificial insemination (AI) methods with fresh and frozen sperm in sheep. In experiment 1, one hundred and fifty fat tailed Zandi ewes were assigned into 3 equal groups and inseminated with three AI methods consisting of vaginal, laparoscopic and trans-cervical AI with fresh semen. In experiment 2, a factorial study (3 AI methods × 2 extenders) was used to analyze the effects of three AI methods and two freezing extenders containing soybean lecithin (SL) or Egg yolk (EY) on reproductive performance of 300 fat tailed Zandi ewes...
November 28, 2016: Cryobiology
https://www.readbyqxmd.com/read/27908066/discrimination-of-amplitude-modulation-depth-by-subjects-with-normal-and-impaired-hearing
#5
Josef Schlittenlacher, Brian C J Moore
The loudness recruitment associated with cochlear hearing loss increases the perceived amount of amplitude modulation (AM), called "fluctuation strength." For normal-hearing (NH) subjects, fluctuation strength "saturates" when the AM depth is high. If such saturation occurs for hearing-impaired (HI) subjects, they may show poorer AM depth discrimination than NH subjects when the reference AM depth is high. To test this hypothesis, AM depth discrimination of a 4-kHz sinusoidal carrier, modulated at a rate of 4 or 16 Hz, was measured in a two-alternative forced-choice task for reference modulation depths, mref, of 0...
November 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27904216/scapholunate-ligament-reconstruction-using-the-palmaris-longus-tendon-and-suture-anchor-fixation-in-chronic-scapholunate-instability
#6
Maulik Jagdish Gandhi, Timothy Paul Knight, Peter John Ratcliffe
BACKGROUND: Multiple reconstruction techniques have been described in the management of chronic scapholunate (SL) instability, either based on the capsulodesis or tenodesis principle. It is uncertain which surgical method produces the best patient outcomes. We describe results of a technique using palmaris longus (PL) tendon for surgical reconstruction of the SL ligament and provide functional outcomes scores. MATERIALS AND METHODS: We surgically reconstructed the SL ligament using a PL tendon graft secured with Mitek(®) bone anchors...
November 2016: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/27902462/the-synthetic-lethal-killing-of-rad54b-deficient-colorectal-cancer-cells-by-parp1-inhibition-is-enhanced-with-sod1-inhibition
#7
Erin N McAndrew, Chloe C Lepage, Kirk J McManus
Colorectal cancer (CRC) is a leading cause of cancer-related death throughout the world. Despite improved screening efforts, most CRCs are diagnosed at late stages when surgery alone is not curative. Moreover, the low 5-year survival rate (~8-13%) for those living with stage IV CRC highlights the need for better treatment options. Many current chemotherapeutic approaches are non-specific and associated with side effects due to their tendency to target both normal and cancer cells. To address this issue, synthetic lethal (SL) approaches are now being explored in cancer and are defined as the lethal combination of two independently viable mutations/deletions...
November 26, 2016: Oncotarget
https://www.readbyqxmd.com/read/27900486/staging-laparoscopy-for-advanced-gastric-cancer-significance-of-preoperative-clinicopathological-factors
#8
Hisahiro Hosogi, Hisashi Shinohara, Shigeru Tsunoda, Shigeo Hisamori, Hitoshi Sumida, Koya Hida, Kazutaka Obama, Hiroshi Okabe, Yoshiharu Sakai
PURPOSE: Although the use of staging laparoscopy (SL) for detecting peritoneal metastasis (P) and determining peritoneal lavage cytology (CY) is widespread in advanced gastric cancer, an indication for SL based on preoperative clinicopathological factors is controversial. METHODS: From May 2006 to September 2015, 120 patients with advanced gastric cancer with primary tumors ≥5 cm and/or with bulky regional lymph nodes (bulky N) underwent SL for assessment of P/CY status...
November 29, 2016: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/27899592/an-mrna-specific-trnai-carrier-eif2a-plays-a-pivotal-role-in-cell-proliferation-under-stress-conditions-stress-resistant-translation-of-c-src-mrna-is-mediated-by-eif2a
#9
Oh Sung Kwon, Sihyeon An, Eunah Kim, Jinbae Yu, Ka Young Hong, Jae Seung Lee, Sung Key Jang
c-Src, a non-receptor protein tyrosine kinase, activates NF-κB and STAT3, which in turn triggers the transcription of anti-apoptosis- and cell cycle-related genes. c-Src protein regulates cell proliferation, cell motility and programmed cell death. And the elevated level of activated c-Src protein is related with solid tumor generation. Translation of c-Src mRNA is directed by an IRES element which mediates persistent translation under stress conditions when translation of most mRNAs is inhibited by a phosphorylation of the alpha subunit of eIF2 carrying the initiator tRNA (tRNAi) to 40S ribosomal subunit under normal conditions...
November 28, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27898769/comparing-the-predictive-abilities-of-phenotypic-and-marker-assisted-selection-methods-in-a-biparental-lettuce-population
#10
Steffen Hadasch, Ivan Simko, Ryan J Hayes, Joseph O Ogutu, Hans-Peter Piepho
Breeding for traits with polygenic inheritance is a challenging task that can be done by phenotypic selection, marker-assisted selection (MAS) or genome-wide selection. We comparatively evaluated the predictive abilities of four selection models on a biparental lettuce ( L.) population genotyped with 95 single nucleotide polymorphisms and 205 amplified fragment length polymorphism markers. These models were based on (i) phenotypic selection, (ii) MAS (with quantitative trait locus (QTL)-linked markers), (iii) genomic prediction using all the available molecular markers, and (iv) genomic prediction using molecular markers plus QTL-linked markers as fixed covariates...
March 2016: Plant Genome
https://www.readbyqxmd.com/read/27897989/periodization-of-carbohydrate-intake-short-term-effect-on-performance
#11
Laurie-Anne Marquet, Christophe Hausswirth, Odeline Molle, John A Hawley, Louise M Burke, Eve Tiollier, Jeanick Brisswalter
BACKGROUND: "Sleep-low" consists of a sequential periodization of carbohydrate (CHO) availability-low glycogen recovery after "train high" glycogen-depleting interval training, followed by an overnight-fast and light intensity training ("train low") the following day. This strategy leads to an upregulation of several exercise-responsive signaling proteins, but the chronic effect on performance has received less attention. We investigated the effects of short-term exposure to this strategy on endurance performance...
November 25, 2016: Nutrients
https://www.readbyqxmd.com/read/27896590/improvement-in-thermal-stability-of-sucralose-by-%C3%AE-cyclodextrin-metal-organic-frameworks
#12
Nana Lv, Tao Guo, Botao Liu, Caifen Wang, Vikaramjeet Singh, Xiaonan Xu, Xue Li, Dawei Chen, Ruxandra Gref, Jiwen Zhang
PURPOSE: To explain thermal stability enhancement of an organic compound, sucralose, with cyclodextrin based metal organic frameworks. METHODS: Micron and nanometer sized basic CD-MOFs were successfully synthesized by a modified vapor diffusion method and further neutralized with glacial acetic acid. Sucralose was loaded into CD-MOFs by incubating CD-MOFs with sucralose ethanol solutions. Thermal stabilities of sucralose-loaded basic CD-MOFs and neutralized CD-MOFs were investigated using thermogravimetric analysis (TGA), differential scanning calorimetry (DSC) and high performance liquid chromatography with evaporative light-scattering detection (HPLC-ELSD)...
November 28, 2016: Pharmaceutical Research
https://www.readbyqxmd.com/read/27890489/spinal-muscular-atrophy-types-i-and-ii-what-are-the-differences-in%C3%A2-body-composition-and-resting-energy-expenditure
#13
Simona Bertoli, Ramona De Amicis, Chiara Mastella, Giulia Pieri, Ester Giaquinto, Alberto Battezzati, Alessandro Leone, Giovanni Baranello
BACKGROUND & AIMS: Different neuromuscular functional domains in types I and II Spinal Muscular Atrophy (SMAI and SMAII) could lead to differences in body composition (BC) and resting energy expenditure (REE). Their identification could provide the key to defining appropriate strategies in clinical dietary management, but data comparing SMAI and SMAII in terms of BC and REE are not yet available. We measured total and regional fat (FM), lean (LBM), mineral (BMC) masses, body water (total, intra- and extra-cellular, TBW, ICW, ECW) and REE in a sample of SMAI and II children, matched for age and sex, and also adjusting for body size to compare these features of the two SMA phenotypes...
November 16, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27890246/treatment-of-dynamic-scapholunate-instability-dissociation-contribution-of-arthroscopy
#14
C Mathoulin
Scapholunate (SL) ligament injuries generally result from trauma to an extended, supinated wrist, leading to chronic instability that progresses toward osteoarthritis. They can occur together with distal radius fracture. These injuries can be difficult to diagnose, especially early on. Treating chronic SL ligament injuries before the onset of osteoarthritis is still a challenge for surgeons. Until recently, the recommended treatments consisted of open SL ligament reconstruction or repair procedures that reduce pain and improve pinch strength but also lead to wrist stiffness...
December 2016: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/27885473/the-application-of-a-new-type-of-titanium-mesh-cage-in-hybrid-anterior-decompression-and-fusion-technique-for-the-treatment-of-continuously-three-level-cervical-spondylotic-myelopathy
#15
Xiaowei Liu, Yu Chen, Haisong Yang, Tiefeng Li, Haidong Xu, Bin Xu, Deyu Chen
PURPOSE: To evaluate the efficacy and safety of a new type of titanium mesh cage (NTMC) in hybrid anterior decompression and fusion method (HDF) in treating continuously three-level cervical spondylotic myelopathy (TCSM). METHODS: Ninety-four cases who had TCSM and accepted the HDF from Jan 2007 to Jan 2010 were included. Clinical and radiological outcomes were compared between cases who had the NTMC (Group A, n = 45) and traditional titanium mesh cage (TTMC, Group B, n = 49) after corpectomies...
November 24, 2016: European Spine Journal
https://www.readbyqxmd.com/read/27884526/impacts-of-changes-in-climate-and-landscape-pattern-on-ecosystem-services
#16
Ruifang Hao, Deyong Yu, Yupeng Liu, Yang Liu, Jianmin Qiao, Xue Wang, Jinshen Du
The restoration of degraded vegetation can effectively improve ecosystem services, increase human well-being, and promote regional sustainable development. Understanding the changing trends in ecosystem services and their drivers is an important step in informing decision makers for the development of reasonable landscape management measures. From 2001 to 2014, we analyzed the changing trends in five critical ecosystem services in the Xilingol Grassland, which is typical of grasslands in North China, including net primary productivity (NPP), soil conservation (SC), soil loss due to wind (SL), water yield (WY) and water retention (WR)...
November 22, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27880943/tp53-mutations-expression-and-interaction-networks-in-human-cancers
#17
Xiaosheng Wang, Qingrong Sun
Although the associations of p53 dysfunction, p53 interaction networks and oncogenesis have been widely explored, a systematic analysis of TP53 mutations and its related interaction networks in various types of human cancers is lacking. Our study explored the associations of TP53 mutations, gene expression, clinical outcomes, and TP53 interaction networks across 33 cancer types using data from The Cancer Genome Atlas (TCGA). We show that TP53 is the most frequently mutated gene in a number of cancers, and its mutations appear to be early events in cancer initiation...
November 21, 2016: Oncotarget
https://www.readbyqxmd.com/read/27878460/comparative-analysis-of-common-regions-found-in-babuviruses-and-alphasatellite-molecules
#18
Daisy Stainton, Darren P Martin, David A Collings, Arvind Varsani
Viruses in the genus Babuvirus have multi-component ssDNA genomes and often associate with alphasatellite molecules containing two common motifs, a common-region stem-loop (CR-SL) involved in initiation of rolling-circle replication and a common-region major (CR-M) motif involved in secondary-strand synthesis. We compared known babuvirus genome components and alphasatellite CR-SL and CR-M sequences, defining five divergent CR-SL sequence classes. We identified iterated sequence elements in babuvirus genome components that have particularly conserved sequences and spatial arrangements between known babuviruses...
November 22, 2016: Archives of Virology
https://www.readbyqxmd.com/read/27877155/weak-and-saturable-protein-surfactant-interactions-in-the-denaturation-of-apo-%C3%AE-lactalbumin-by-acidic-and-lactonic-sophorolipid
#19
Kell K Andersen, Brian S Vad, Sophie Roelants, Inge N A van Bogaert, Daniel E Otzen
Biosurfactants are of growing interest as sustainable alternatives to fossil-fuel-derived chemical surfactants, particularly for the detergent industry. To realize this potential, it is necessary to understand how they affect proteins which they may encounter in their applications. However, knowledge of such interactions is limited. Here, we present a study of the interactions between the model protein apo-α-lactalbumin (apo-aLA) and the biosurfactant sophorolipid (SL) produced by the yeast Starmerella bombicola...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27877101/from-molecules-to-the-clinic-linking-schizophrenia-and-metabolic-syndrome-through-sphingolipids-metabolism
#20
REVIEW
Rolando I Castillo, Leonel E Rojo, Marcela Henriquez-Henriquez, Hernán Silva, Alejandro Maturana, María J Villar, Manuel Fuentes, Pablo A Gaspar
Metabolic syndrome (MS) is a prevalent and severe comorbidity observed in schizophrenia (SZ). The exact nature of this association is controversial and very often accredited to the effects of psychotropic medications and disease-induced life-style modifications, such as inactive lifestyle, poor dietary choices, and smoking. However, drug therapy and disease-induced lifestyle factors are likely not the only factors contributing to the observed converging nature of these conditions, since an increased prevalence of MS is also observed in first episode and drug-naïve psychosis populations...
2016: Frontiers in Neuroscience
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