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https://www.readbyqxmd.com/read/29239312/endogenous-retinal-neural-stem-cell-reprogramming-for-neuronal-regeneration
#1
REVIEW
Romain Madelaine, Philippe Mourrain
In humans, optic nerve injuries and associated neurodegenerative diseases are often followed by permanent vision loss. Consequently, an important challenge is to develop safe and effective methods to replace retinal neurons and thereby restore neuronal functions and vision. Identifying cellular and molecular mechanisms allowing to replace damaged neurons is a major goal for basic and translational research in regenerative medicine. Contrary to mammals, the zebrafish has the capacity to fully regenerate entire parts of the nervous system, including retina...
November 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/29239280/perceived-injustice-and-its-correlates-after-mild-traumatic-brain-injury
#2
Grant L Iverson, Douglas P Terry, Justin E Karr, William Panenka, Noah D Silverberg
Perceived injustice is a belief that one has been treated unfairly, disrespectfully, and is suffering unnecessarily as a result of another person's actions. Perceived injustice predicts chronic disability after musculoskeletal injury, but to our knowledge, has not been empirically studied in people with mild traumatic brain injuries (MTBIs). We examined perceived injustice and its correlates in patients who were slow to recover from MTBI. Patients (N=102) were recruited from four concussion clinics. The sample was on average 41...
December 14, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29235939/are-shoulder-counter-rotation-and-hip-shoulder-separation-angle-representative-metrics-of-three-dimensional-spinal-kinematics-in-cricket-fast-bowling
#3
Billy Senington, Raymond Y Lee, Jonathan Mark Williams
This study aimed to investigate the relationship between shoulder counter-rotation (SCR), hip shoulder separation (HSS) and three-dimensional spinal kinematics during fast bowling in cricket. Thirty five elite male fast bowlers were analysed using three-dimensional inertial sensors on the spine. Lumbar, thoracic and thoracolumbar kinematics were determined during the delivery stride. Spearman's pairwise correlations displayed significant associations between SCR, thoracic and thoracolumbar lateral flexion between the back foot impact and max contralateral rotation phase of the delivery stride (rs = -...
December 13, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/29235279/-advance-of-a-representative-traditional-tibetan-medicine-meconopsis-horridula-on-its-phytochemical-and-pharmacological-aspects
#4
REVIEW
Feng Zhao, He-Xin-Ge Zhang, Rui-Feng Bai, Bing-Zhao Tu, Xiao-Li Gao, Peng-Fei Tu, Xing-Yun Chai
Meconopsis horridula is one of alpine plants belonging to family Papaveraceae, mainly distributed in Himalaya Range area. M. horridula is a rare alpine flower, and is a kind of traditional Tibetan medicine, which has been included in more than 40 compound formulae, having efficacies of clearing away heat and alleviating pain, activating blood circulation to remove stasis, traditionally used for the treatment of fractures, injuries, and chest and back pains. Modern research shows that the whole plant of M. horridula contains alkaloids, flavonoids, and terpenes, and its pharmacological activities including antitumor, antivirus and myocardial protection etc...
October 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29234231/spectral-domain-optical-coherence-tomography-and-en-face-imaging-in-presumed-ocular-chalcosis
#5
Neha Goel
A 35-year-old male, with a history of injury sustained three years back, underwent pars plana vitrectomy with intravitreal copper foreign body removal. Post-operatively, visual acuity improved; however, glistening refractile particles were seen at the macula. Spectral domain optical coherence tomography and en-face imaging were performed to localise the level of the deposits. To the best of our knowledge, this is the first such documentation in presumed ocular chalcosis.
October 2017: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/29233749/an-amendment-to-the-neidre-and-macnab-classification-system-for-lumbosacral-nerve-root-anomaly-and-its-implication-in-percutaneous-endoscopic-lumbar-discectomy
#6
Chen Yu, Chang Zhengqi, Yu Xiuchun
BACKGROUND: Lumbar disc herniation complicated with nerve root anomaly presents great challenges to diagnosis and treatment, improper selection of surgical procedures may cause inferior outcomes and neurological injury. CASE DESCRIPTION: A 66-year old male presented with low back pain and radicular symptoms involving bilateral L-5 and S-1 nerve roots. Instead of percutaneous endoscopic lumbar discectomy, aggressive decompression was carried out due to deviation between examination and imaging findings...
December 9, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29232762/review-article-best-practice-management-of-low-back-pain-in-the-emergency-department-part-1-of-the-musculoskeletal-injuries-rapid-review-series
#7
REVIEW
Kirsten Strudwick, Megan McPhee, Anthony Bell, Melinda Martin-Khan, Trevor Russell
Low back pain (LBP) is a common presentation to the ED, and a frequent cause of disability globally. The ED management is often associated with high rates of imaging, misuse and overuse of pharmacology and subsequent financial implications. Given this, improved quality of care for patients with LBP in ED is essential. This rapid review investigated best practice for the assessment and management of LBP in the ED. PubMed, CINAHL, EMBASE, TRIP and the grey literature, including relevant organisational websites, were searched in 2015...
December 12, 2017: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/29231892/assessment-of-plumage-and-integument-condition-in-dual-purpose-breeds-and-conventional-layers
#8
Mona Franziska Giersberg, Birgit Spindler, Nicole Kemper
The assessment of plumage and integument condition in laying hens provides useful information about the occurrence of feather pecking and cannibalism. Although feather loss and skin injuries can result from mechanical abrasion or clinical diseases, they are valid animal-based indicators for behavioural disorders. This particularly applies to damage on the back and tail region of the hens. The aim was to evaluate the behaviour of dual-purpose breeds (Lohmann Dual, LD) and conventional layer hybrids (Lohmann Brown plus, LB+), and to compare a mere visual assessment (Visual Scoring, VSc), with a method involving the handling of individual animals (Hands-on Scoring, HSc)...
December 12, 2017: Animals: An Open Access Journal From MDPI
https://www.readbyqxmd.com/read/29231023/-analysis-on-the-injury-mechanism-and-characteristics-of-ox-horn
#9
W L Zhang, Y L Du
OBJECTIVES: To study the morphological characteristics of the injury caused by ox horn on human body and its injury mechanism, and to discuss the rules and characteristics of injury by ox horn and provide forensic evidences for identification of such cases. METHODS: The comparative analysis of position and morphological characteristics were performed by summarizing the data of 100 victims gored by ox accepted by Heilongjiang agricultural areas public security bureau during 2004-2014...
April 2017: Fa Yi Xue za Zhi
https://www.readbyqxmd.com/read/29229774/ethical-considerations-for-the-design-and-implementation-of-child-injury-prevention-interventions-the-example-of-delivering-and-installing-safety-equipment-into-the-home
#10
Beatrice Scholtes, Peter Schröder-Bäck
INTRODUCTION: Public health ethics is a growing field of academic interest but ethical discussion of injury prevention seems to have received limited attention. Interventions that promise to be effective are not necessarily-without explicit justification-'good' and 'right' interventions in every sense. This paper explores public health ethics in the context of child injury prevention with the objective to initiate interdisciplinary dialogue on the ethics of child safety interventions...
December 11, 2017: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
https://www.readbyqxmd.com/read/29225016/posterior-cruciate-ligament-injuries-of-the-knee-at-the-national-football-league-combine-an-imaging-and-epidemiology-study
#11
Catherine A Logan, Brendin R Beaulieu-Jones, George Sanchez, Jorge Chahla, Nicholas I Kennedy, Mark E Cinque, Robert F LaPrade, James M Whalen, Bryan G Vopat, Mark D Price, Matthew T Provencher
PURPOSE: To determine the epidemiology by player position, examination, imaging findings, and associated injuries of posterior cruciate ligament (PCL) injuries in players participating in the National Football League (NFL) Combine. METHODS: All PCL injuries identified at the NFL Combine (2009-2015) were reviewed. Data were obtained from the database organized by the NFL medical personnel for the compilation of the medical and physical performance examination results of NFL Draftees participating in the NFL Combine from 2009 to 2015...
December 7, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29223674/prediction-of-need-for-intervention-in-posterior-urethral-valves-use-of-urine-osmolality
#12
Anna E Wright, Ruth Wragg, Joana Lopes, Andrew Robb, Liam McCarthy
AIM: Renal tubular dysfunction (RTD) causing obligate production of hypoosmolar urine in boys with posterior urethral valves (PUVs) has been described. It is not known how clinically significant this is. We hypothesize that a feedback loop is present in many PUV boys who suffer deterioration of their lower urinary tract (LUT). RTD results in hypoosmolar urine, obligate polyuria, and bladder stretch-injury. The increasing back-pressure worsens RTD, thus exacerbating the injury. Coexisting renal dysplasia and acquired renal scarring exacerbate this...
November 14, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29221810/mitochondrial-dysfunction-and-damage-associated-molecular-patterns-damps-in-chronic-inflammatory-diseases
#13
REVIEW
Charles S Dela Cruz, Min-Jong Kang
Inflammation represents a comprehensive host response to external stimuli for the purpose of eliminating the offending agent, minimizing injury to host tissues and fostering repair of damaged tissues back to homeostatic levels. In normal physiologic context, inflammatory response culminates with the resolution of infection and tissue damage response. However, in a pathologic context, persistent or inappropriately regulated inflammation occurs that can lead to chronic inflammatory diseases. Recent scientific advances have integrated the role of innate immune response to be an important arm of the inflammatory process...
December 5, 2017: Mitochondrion
https://www.readbyqxmd.com/read/29214900/injury-related-hospital-admission-of-female-firefighters-in-south-korea
#14
Ji Young Song, Min-Gi Kim, Yeon-Soon Ahn
PURPOSE: The main objective of this study was to ascertain whether injury related hospital admission in all South Korea female firefighters is greater than that in the general population. METHODS: To perform this comparison, the standardized admission ratios (SARs) and their 95% confidence intervals (CI) were calculated by person-years and mortality computation software. RESULTS: Compared to the general population, the SARs of overall injury (SAR =1...
December 7, 2017: International Journal of Occupational Safety and Ergonomics: JOSE
https://www.readbyqxmd.com/read/29211751/diffusion-tensor-imaging-detects-ventilation-induced-brain-injury-in-preterm-lambs
#15
Dhafer M Alahmari, Kyra Y Y Chan, Vanesa Stojanovska, Domenic LaRosa, Samantha K Barton, Ilias Nitsos, Valerie Zahra, Jade Barbuto, Michael Farrell, Shigeo Yamaoka, James T Pearson, Graeme R Polglase
PURPOSE: Injurious mechanical ventilation causes white matter (WM) injury in preterm infants through inflammatory and haemodynamic pathways. The relative contribution of each of these pathways is not known. We hypothesised that in vivo magnetic resonance imaging (MRI) can detect WM brain injury resulting from mechanical ventilation 24 h after preterm delivery. Further we hypothesised that the combination of inflammatory and haemodynamic pathways, induced by umbilical cord occlusion (UCO) increases brain injury at 24 h...
2017: PloS One
https://www.readbyqxmd.com/read/29209426/early-career-members-at-the-ers-lsc-2017-mechanistic-overlap-between-chronic-lung-injury-and-cancer
#16
Isaac Almendros, Sabine Bartel, Clementine Bostantzoglou, Jamil Jubrail, Mareike Lehmann, Darcy Wagner
.@EarlyCareerERS looks back on #LSC2017 http://ow.ly/I3M730fkn5X.
December 2017: Breathe
https://www.readbyqxmd.com/read/29207908/a-scoping-review-of-pain-in-children-following-traumatic-brain-injury-is-there-more-than-headache
#17
Vivian Kwan, Mai Vo, Melanie Noel, Keith Owen Yeates
AIM: Headache is a common source of pain in children following traumatic brain injury (TBI); however, relatively little is known about non-headache pain in this pediatric population. The present review seeks to map the extant literature to determine the prevalence, characteristics, and impact of non-headache pain in children following TBI of all severities. RESULTS: Of 109 studies published on pain in children following a TBI, 95 (87%) were focused exclusively on headache pain and only 14 (13%) reported on non-headache pain or overall pain, with half (n = 7) in the form of case studies...
December 5, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29206556/intravitreal-subretinal-and-suprachoroidal-injections-evolution-of-microneedles-for-drug-delivery
#18
Rachel R Hartman, Uday B Kompella
Even though the very thought of an injection into the eye may be frightening, an estimated 6 million intravitreal (IVT) injections were made in the USA during 2016. With the introduction of new therapeutic agents, this number is expected to increase. In addition, drug products that are injectable in ocular compartments other than the vitreous humor are expected to enter the back of the eye market in the not so distant future. Besides the IVT route, some of the most actively investigated routes of invasive administration to the eye include periocular, subretinal, and suprachoroidal (SC) routes...
December 5, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29205215/symmetry-of-lower-limb-loading-in-healthy-adults-during-normal-and-abnormal-stance
#19
Jacek Stodółka, Małgorzata Sobera
PURPOSE: The purpose of the research was twofold: (1) to describe the normal asymmetry in lower limb loading during a normal stance and during a stance with visual and vestibular disturbance relating to the lower limb dominance, (2) to assess relations of loading of both lower limbs with body weight and height (BMI) and leg functional dominance. METHODS: The subjects of this study were 95 students. Settings of the two Kistler platforms were used to register the time series of the vertical component of the ground reaction force while the subject was standing (45 seconds) in a normal position and next with eyes covered with a band and head tilted back position with one leg placed on one platform and the other on the second platform...
2017: Acta of Bioengineering and Biomechanics
https://www.readbyqxmd.com/read/29203713/therapeutic-potential-of-heat-shock-protein-induction-for-muscular-dystrophy-and-other-muscle-wasting-conditions
#20
REVIEW
Savant S Thakur, Kristy Swiderski, James G Ryall, Gordon S Lynch
Duchenne muscular dystrophy is the most common and severe of the muscular dystrophies, a group of inherited myopathies caused by different genetic mutations leading to aberrant expression or complete absence of cytoskeletal proteins. Dystrophic muscles are prone to injury, and regenerate poorly after damage. Remorseless cycles of muscle fibre breakdown and incomplete repair lead to progressive and severe muscle wasting, weakness and premature death. Many other conditions are similarly characterized by muscle wasting, including sarcopenia, cancer cachexia, sepsis, denervation, burns, and chronic obstructive pulmonary disease...
January 19, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
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