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https://www.readbyqxmd.com/read/29619130/copeptin-as-a-prognostic-marker-in-acute-chest-pain-and-suspected-acute-coronary-syndrome
#1
Beata Morawiec, Damian Kawecki, Brygida Przywara-Chowaniec, Mariusz Opara, Piotr Muzyk, Lam Ho, Lui Chun Tat, Artur Gabrysiak, Olivier Muller, Ewa Nowalany-Kozielska
Background: In patients admitted with chest pain and suspected acute coronary syndrome (ACS), it is crucial to early identify those who are at higher risk of adverse events. The study aim was to assess the predictive value of copeptin in patients admitted to the emergency department with chest pain and nonconclusive ECG. Methods: Consecutive patients suspected for an ACS were enrolled prospectively. Copeptin and high-sensitive troponin T (hs-TnT) were measured at admission...
2018: Disease Markers
https://www.readbyqxmd.com/read/29575675/novel-oral-anticoagulant-use-in-adult-fontan-patients-a-single-center-experience
#2
Justin Georgekutty, Amir Kazerouninia, YunFei Wang, Peter R Ermis, Dhaval R Parekh, Wayne J Franklin, Wilson W Lam
OBJECTIVE: Adult Fontan patients are at increased risk for thrombosis and thromboembolic complications leading to increased morbidity and mortality. Most are prescribed antiplatelet or anticoagulant therapy for thromboprophylaxis; novel oral anticoagulants (NOACs) are uncommonly used given lack of data on their use in this population and generalized concerns regarding Fontan patients' abnormal coagulation. We report the largest single-center experience with the use of NOACs for treatment and prophylaxis of thrombosis and thromboembolism in adult Fontan patients...
March 24, 2018: Congenital Heart Disease
https://www.readbyqxmd.com/read/29550355/urine-oligosaccharide-screening-by-maldi-tof-for-the-identification-of-ngly1-deficiency
#3
Patricia L Hall, Christina Lam, John J Alexander, Ghazia Asif, Gerard T Berry, Carlos Ferreira, Hudson H Freeze, William A Gahl, Kim K Nickander, Jon D Sharer, Caroline M Watson, Lynne Wolfe, Kimiyo M Raymond
N-glycanase deficiency (NGLY1 deficiency, NGLY1-CDDG), the first autosomal recessive congenital disorder of N-linked deglycosylation (CDDG), is caused by pathogenic variants in NGLY1. The majority of affected individuals have been identified using exome or genome sequencing. To date, no reliable, clinically available biomarkers have been identified. Urine oligosaccharide analysis was included as part of a routine evaluation for possible biomarkers in patients with confirmed NGLY1-CDDG. During the qualitative review of oligosaccharide profiles by an experienced laboratory director an abnormal analyte with a proposed structure of Neu5Ac1Hex1GlcNAc1-Asn was identified in NGLY1-CDDG patient urine samples...
March 10, 2018: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/29519926/rates-of-change-in-fev-1-and-dl-co-as-potential-indicators-for-mtor-inhibitor-therapy-in-pre-menopausal-lymphangioleiomyomatosis-patients
#4
Angelo M Taveira-DaSilva, Patricia Julien-Williams, Amanda M Jones, Mario Stylianou, Joel Moss
The value of rates of change in FEV1 and DLCO to predict disease progression, and initiation of mTOR inhibitor therapy has not been evaluated.In 84 pre-menopausal LAM patients, individual rates of change in FEV1 and DLCO and 95% confidence intervals (CI), were used to derive subsequent lowest values of FEV1 and DLCO that would prompt initiation of sirolimus therapy. These treatment criteria were compared with one based on FEV1 or DLCO ≤70% predicted. In 12 patients undergoing sirolimus therapy both methods for determining the optimal point for initiation of therapy were evaluated...
March 8, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29519353/etidronate-for-prevention-of-ectopic-mineralization-in-patients-with-pseudoxanthoma-elasticum
#5
Guido Kranenburg, Pim A de Jong, Jonas W Bartstra, Suzanne J Lagerweij, Marnix G Lam, Jeannette Ossewaarde-van Norel, Sara Risseeuw, Redmer van Leeuwen, Saskia M Imhof, Harald J Verhaar, Job J de Vries, Riemer H J A Slart, Gert Luurtsema, Annemarie M den Harder, Frank L J Visseren, Willem P Mali, Wilko Spiering
BACKGROUND: In pseudoxanthoma elasticum (PXE), low pyrophosphate levels may cause ectopic mineralization, leading to skin changes, visual impairment, and peripheral arterial disease. OBJECTIVES: The authors hypothesized that etidronate, a pyrophosphate analog, might reduce ectopic mineralization in PXE. METHODS: In the Treatment of Ectopic Mineralization in Pseudoxanthoma Elasticum trial, adults with PXE and leg arterial calcifications (n = 74) were randomly assigned to etidronate or placebo (cyclical 20 mg/kg for 2 weeks every 12 weeks)...
March 13, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29509590/time-to-first-line-art-failure-and-time-to-second-line-art-switch-in-the-iedea-pediatric-cohort
#6
Kara Wools-Kaloustian, Irene Marete, Samuel Ayaya, Annette H Sohn, Lam Van Nguyen, Shanshan Li, Valériane Leroy, Beverly S Musick, Jamie E Newman, Andrew Edmonds, Mary-Ann Davies, François Tanoh Eboua, Marie-Thérèse Obama, Marcel Yotebieng, Shobna Sawry, Lynne M Mofenson, Constantin T Yiannoutsos
BACKGROUND: Globally, 49% of the estimated 1.8 million children living with HIV are accessing antiretroviral therapy (ART). There are limited data concerning long-term durability of first-line ART regimens and time to transition to second-line. METHODS: Children initiating their first ART regimen between 2-14 years of age and enrolled in one of 208 sites in 30 Asia-Pacific and African countries participating in the Pediatric International Epidemiology Databases to Evaluate AIDS consortium were included in this analysis...
March 2, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29505194/cognitive-impairment-in-major-depressive-disorder-a-case-discussion-illustrating-impact-assessment-and-management
#7
Larry Culpepper, Raymond W Lam, Roger S McIntyre
How can you help your patients who are experiencing both depression and cognitive dysfunction? Tune in to this CME podcast to hear experts in psychiatry discuss 2 patient cases that illustrate the burden of cognitive impairment in major depressive disorder as well as effective assessment tools and management strategies.
January 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29494475/survival-and-safety-outcomes-of-icu-patients-discharged-directly-home-a-direct-from-icu-sent-home-study
#8
Vincent I Lau, Joyce N H Lam, John Basmaji, Fran A Priestap, Ian M Ball
OBJECTIVES: Evaluate outcomes (mortality, morbidity, unplanned return visits) of patients who are discharged directly to home from the ICU. DESIGN: Prospective cohort study. SETTING: Two tertiary care medical-surgical-trauma ICUs at Canadian hospitals over 1 year (February 2016-2017). SUBJECTS: All adult patients who were either discharged directly to home (Recruited and Nonrecruited cohorts) from ICU or discharged home within 24 hours after ward transfer (Ward Transfer cohort)...
February 28, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29378606/treponema-pallidum-immunohistochemistry-is-positive-in-human-intestinal-spirochetosis
#9
Rondell P Graham, Bita V Naini, Sejal S Shah, Christina A Arnold, Rajesh Kannangai, Michael S Torbenson, Dora M Lam-Himlin
BACKGROUND: Human intestinal spirochetosis (IS) has been recognized for decades, but whether it represents commensalism or a pathogenic process remains controversial. IS is diagnosed on routine stains with confirmation by silver stains but these stains are labor intensive and slow to read. We evaluated the Treponema pallidum immunostain as a diagnostic adjunct for IS. METHODS: We retrieved biopsies from 33 patients with IS for this study. Each case was tested by Warthin-Starry (WS) and T...
January 22, 2018: Diagnostic Pathology
https://www.readbyqxmd.com/read/29370965/preventing-brachial-plexus-injury-during-shoulder-surgery-a-real-time-cadaveric-study
#10
Andrew W Kam, Patrick H Lam, Pieter S W A Haen, Martin Tan, Aminudin Shamsudin, George A C Murrell
BACKGROUND: Brachial plexopathy is not uncommon after shoulder surgery. Although thought to be due to stretch neuropathy, its etiology is poorly understood. This study aimed to identify arm positions and maneuvers that may risk causing brachial plexopathy during shoulder arthroplasty. METHODS: Tensions in the cords of the brachial plexuses of 6 human cadaveric upper limbs were measured using load cells while each limb was placed in different arm positions and while they underwent shoulder hemiarthroplasty and revision reverse arthroplasty...
January 19, 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29348085/toxic-effect-of-common-poisonous-plants-of-district-bannu-khyber-pakhtunkhwa-pakistan
#11
Rehman Ullah Khan, Sultan Mehmood, Saad Ullah Khan
The present paper was a part of Ph.D research work, conducted during the year 2014, in which 87 poisonous plants belonging to 54 genera, were collected, documented and preserved in the herbarium of Bannu, Department of Botany UST, Bannu Khyber Pakhtunkwa Pakistan. The plants were identified botanically, arranged alphabetically along with their Latin name, family name, common name, poisonous parts, toxicity, affects, toxin and their effects. Aim of the study was to induce awareness in the local people of district Bannu about the poisonous effects of the commonly used plants...
January 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29329350/incidence-and-risk-factors-for-postoperative-lingual-neuropraxia-following-airway-instrumentation-a-retrospective-matched-case-control-study
#12
Yi-Kai Su, Jen-Hung Wang, Shiu-Ying Hsieh, Xiu-Zhu Liu, Chen-Fuh Lam, Shian-Che Huang
BACKGROUND: Lingual nerve injury or neuropraxia is a rare but potentially serious perioperative complication following airway instrumentation during general anesthesia. This study explored the the incidence and perioperative risk factors for lingual nerve injury in patients receiving laryngeal mask (LMA) or endotracheal (ETGA) general anesthesia in a single center experience. METHODS AND RESULTS: All surgical patients in our hospital who received LMA or ETGA from 2009 to 2013 were included, and potential perioperative risk factors were compared...
2018: PloS One
https://www.readbyqxmd.com/read/29329305/evaluating-the-efficacy-of-switching-from-lamivudine-plus-adefovir-to-tenofovir-disoproxil-fumarate-monotherapy-in-lamivudine-resistant-stable-hepatitis-b-patients
#13
RANDOMIZED CONTROLLED TRIAL
Heon Ju Lee, Sang Jin Kim, Young Oh Kweon, Soo Young Park, Jeong Heo, Hyun Young Woo, Jae Seok Hwang, Woo Jin Chung, Chang Hyeong Lee, Byung Seok Kim, Jeong Ill Suh, Won Young Tak, Byoung Kuk Jang
BACKGROUND: The efficacy of switching to tenofovir disoproxil fumarate (TDF) monotherapy from lamivudine (LAM) plus adefovir dipivoxil (ADV) combination therapy (stable switching) in patients with LAM-resistant chronic hepatitis B (CHB) and undetectable hepatitis B virus (HBV) DNA is not clear. METHODS: In this non-inferiority trial, patients with LAM-resistant CHB and undetectable serum HBV DNA (<20 IU/mL) for >6 months after initiating LAM+ADV combination therapy were randomized (1:2) either to continue the combination therapy (LAM+ADV group, n = 58) or switched to TDF monotherapy (TDF group, n = 111)...
2018: PloS One
https://www.readbyqxmd.com/read/29315963/distinct-and-heterogeneous-trajectories-of-self-perceived-cognitive-impairment-among-asian-breast-cancer-survivors
#14
Terence Ng, Sreemanee Raaj Dorajoo, Yin Ting Cheung, Yick Ching Lam, Hui Ling Yeo, Maung Shwe, Yan Xiang Gan, Koon Mian Foo, Wei-Jen Kiley Loh, Si-Lin Koo, Amit Jain, Guek Eng Lee, Rebecca Dent, Yoon Sim Yap, Raymond Ng, Alexandre Chan
OBJECTIVES: Currently, there are no studies that have established the self-perceived cognitive trajectories experienced by breast cancer patients (BCPs) post-chemotherapy. Therefore, we characterized the long-term trajectory of self-perceived cognitive function among Asian early-stage BCPs using the minimal clinically important difference of a subjective measure of cognitive function. METHODS: Early-stage BCPs who received chemotherapy were recruited and assessed at 4 time points: Before chemotherapy initiation (T1), 6 weeks post-chemotherapy initiation (T2), 12 weeks post-chemotherapy initiation (T3), and 15-months post-chemotherapy initiation (T4)...
April 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29309367/intratumoral-injection-of-radioactive-holmium-166-microspheres-in-recurrent-head-and-neck-squamous-cell-carcinoma-preliminary-results-of-first-use
#15
Robbert C Bakker, Robert J J van Es, Antoine J W P Rosenberg, Sebastiaan A van Nimwegen, Remco Bastiaannet, Hugo W A M de Jong, Johannes F W Nijsen, Marnix G E H Lam
BACKGROUND: Limited treatment options exist for patients with locoregional recurrences of head and neck squamous cell carcinoma (HNSCC). In the palliative setting, a single session, minimally invasive, and relatively safe therapy is desirable. This case series illustrates the feasibility of a direct intratumoral injection of radioactive holmium-166 microspheres (HoMS) in patients as a palliative treatment for recurrent HNSCC. PATIENTS AND METHODS: In this retrospective analysis, patients with already reirradiated irresectable recurrent HNSCC, for whom palliative chemotherapy was unsuccessful or impossible, were offered microbrachytherapy with HoMS...
March 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29283270/an-east-west-comparison-of-self-care-barriers-in-heart-failure
#16
Shir Lynn Lim, Siew Pang Chan, Kim Yee Lee, Anne Ching, Richard J Holden, Karen F Miller, Alan B Storrow, Carolyn Sp Lam, Sean P Collins
BACKGROUND: Barriers in heart failure self-care contribute to heart failure hospitalizations, but geographic differences have not been well-studied. We aimed to compare self-care barriers in heart failure patients managed at tertiary centers in an Eastern (Singapore) versus a Western (USA) nation. METHODS: Acute heart failure patients were prospectively assessed with a standardized instrument comprising of 47 distinct self-care barriers. The multi-equation generalized structural equation model was used to evaluate for geographic differences in barriers experienced, and association of barriers with outcomes...
December 1, 2017: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/29276607/ventilator-associated-respiratory-infection-in-a-resource-restricted-setting-impact-and-etiology
#17
Vu Dinh Phu, Behzad Nadjm, Nguyen Hoang Anh Duy, Dao Xuan Co, Nguyen Thi Hoang Mai, Dao Tuyet Trinh, James Campbell, Dong Phu Khiem, Tran Ngoc Quang, Huynh Thi Loan, Ha Son Binh, Quynh-Dao Dinh, Duong Bich Thuy, Huong Nguyen Phu Lan, Nguyen Hong Ha, Ana Bonell, Mattias Larsson, Hoang Minh Hoan, Đang Quoc Tuan, Hakan Hanberger, Hoang Nguyen Van Minh, Lam Minh Yen, Nguyen Van Hao, Nguyen Gia Binh, Nguyen Van Vinh Chau, Nguyen Van Kinh, Guy E Thwaites, Heiman F Wertheim, H Rogier van Doorn, C Louise Thwaites
Background: Ventilator-associated respiratory infection (VARI) is a significant problem in resource-restricted intensive care units (ICUs), but differences in casemix and etiology means VARI in resource-restricted ICUs may be different from that found in resource-rich units. Data from these settings are vital to plan preventative interventions and assess their cost-effectiveness, but few are available. Methods: We conducted a prospective observational study in four Vietnamese ICUs to assess the incidence and impact of VARI...
2017: Journal of Intensive Care
https://www.readbyqxmd.com/read/29248619/a-new-approach-for-assessing-and-training-drivers-speed-management
#18
Noelle LaVoie, Yi-Ching Lee, Anna Allison, James Parker
Motor vehicle crashes are the leading cause of death and injury for teens and speeding is a major contributor, particularly driving too fast for conditions (CDC, 2015, 2013; NHTSA, 2012; Lam, 2003; McKnight & McKnight, 2003). Speed management is a type of tacit knowledge learned through experience that combines speed perception with decisions about safety. Effective training and assessment of speed management requires a safe method for accumulating practice that includes realistic perceptual cues. This study investigated whether speed can be manipulated in an online environment using special effects technology without distorting speed perception...
February 2018: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29227879/re-thinking-pre-drinking-implications-from-a-sample-of-teenagers-who-drink-in-private-settings
#19
James Wilson, Rowan P Ogeil, Tina Lam, Simon Lenton, Belinda Lloyd, Lucy Burns, Alexandra Aiken, William Gilmore, Tanya Chikritzhs, Richard Mattick, Dan I Lubman, Steve Allsop
No abstract text is available yet for this article.
February 2018: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29208258/durability-of-sirolimus-for-lymphangioleiomyomatosis
#20
Alexandra Martirossian, Shiwan Shah, Lola Carrete, Jose Valle, Vincent Valentine
Lymphangioleiomyomatosis (LAM), a rare, multisystem disorder primarily affecting women of reproductive age, is characterized by cystic-appearing lung lesions, progressive loss of lung function, chylous effusions and renal angiomyolipomas. Sirolimus, an mammalian target of rapamycin inhibitor, has been shown to stabilize lung function, reduce symptoms and resolve chylous effusions in the short term for patients with LAM. Herein, we report a premenopausal female with LAM who experienced complete and durable resolution of her chylothoraces with significant and sustained improvement in lung function on sirolimus...
December 2017: American Journal of the Medical Sciences
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