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Atsushi Takano, Hiroshi Nakagomi, Kou Ikegame, Atsushi Yamamoto, Hideki Watanabe, Haruka Nakada, Masayuki Inoue, Hidemitsu Sugai, Michiya Yasutome, Kazushige Furuya, Masao Hada, Yoshiaki Miyasaka, Toshio Oyama, Masao Omata
INTRODUCTION: The over-expression of P53 protein in gallbladder carcinoma is a biomarker correlating with a poor survival. However, the significance of P53 expression in peritumor tissues is unknown. We experienced a case of gallbladder carcinoma where the operative specimen showed over-expression of P53 on the peritumor epithelium, and early recurrence developed at the biliary tract. PRESENTATION OF CASE: A 74-year-old female patient was referred to our hospital due to wall thickening of the gallbladder on ultrasonography...
October 18, 2016: International Journal of Surgery Case Reports
Keitaro Nakamoto, Masato Watanabe, Mitsuru Sada, Toshiya Inui, Masuo Nakamura, Kojiro Honda, Hiroo Wada, Yu Mikami, Hirotaka Matsuzaki, Masafumi Horie, Satoshi Noguchi, Yasuhiro Yamauchi, Hikari Koyama, Toshiyuki Kogane, Tadashi Kohyama, Hajime Takizawa
BACKGROUND AND PURPOSE: Bronchial asthma (BA) is a chronic airway disease characterized by airway hyperresponsiveness and remodeling, which are intimately linked to chronic airway inflammation. Reactive oxygen species (ROS) such as hydrogen peroxide are generated by inflammatory cells that are involved in the pathogenesis of BA. However, the role of ROS in the management of BA patients is not yet clear. We attempted to determine the role of ROS as a biomarker in the clinical setting of BA...
2016: PloS One
Kun Qian, Christoph Janott, Vedhas Pandit, Zixing Zhang, Clemens Heiser, Winfried Hohenhorst, Michael Herzog, Werner Hemmert, Bjoern Schuller
OBJECTIVE: Obstructive Sleep Apnea (OSA) is a serious chronic disease and a risk factor for cardiovascular diseases. Snoring is a typical symptom of OSA patients. Knowledge of the origin of obstruction and vibration within the upper airways is essential for a targeted surgical approach. Aim of this paper is to systematically compare different acoustic features, and classifiers for their performance in the classification of the excitation location of snore sounds. METHODS: Snore sounds from 40 male patients have been recorded during Drug-Induced Sleep Endoscopy, and categorized by ENT experts...
October 21, 2016: IEEE Transactions on Bio-medical Engineering
V Luzzi, G Di Carlo, M Saccucci, G Ierardo, E Guglielmo, M Fabbrizi, A M Zicari, M Duse, F Occasi, G Conti, E Leonardi, A Polimeni
OBJECTIVE: Sleep-disordered breathing (SDB) is among the most common diseases and includes a group of pathological conditions that form a severity continuum from primary snoring (PS) to obstructive sleep apnea (OSA). SDB presents a multifactorial etiology and in children, it is often linked to adenotonsillar hypertrophy, which may lead to an alteration of the breathing pattern. Therefore, several studies hinted at the existence of a correlation between SDB and the alteration of craniofacial growth...
October 2016: European Review for Medical and Pharmacological Sciences
Ellen Games, Marina Guerreiro, Fernanda R Santana, Nathalia M Pinheiro, Emerson A de Oliveira, Fernanda D T Q S Lopes, Clarice R Olivo, Iolanda F L C Tibério, Mílton A Martins, João Henrique G Lago, Carla M Prado
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is characterized by irreversible airflow obstruction and inflammation. Natural products, such as monoterpenes, displayed anti-inflammatory and anti-oxidant activities and can be used as a source of new compounds to COPD treatment. Our aim was to evaluate, in an elastase-induced pulmonary emphysema in mice, the effects of and underlying mechanisms of three related natural monoterpenes (p-cymene, carvacrol and thymol) isolated from essential oil from leaves Lippia sidoides Cham...
October 20, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Akos Szekely, Suparna Rajaram, Aprajita Mohanty
It is hypothesised that threatening stimuli are detected better due to their salience or physical properties. However, these stimuli are typically embedded in a rich context, motivating the question whether threat detection is facilitated via learning of contexts in which threat stimuli appear. To address this question, we presented threatening face targets in new or old spatial configurations consisting of schematic faces and found that detection of threatening targets was faster in old configurations. This indicates that individuals are able to learn regularities within visual contexts and use this contextual information to guide detection of threatening targets...
October 24, 2016: Cognition & Emotion
Christoph Liebetrau, Luise Gaede, J Sebastian Wolter, Julia Homann, Alexander Meyer, Oliver Dörr, Holger M Nef, Christian Troidl, Christian W Hamm, Helge Möllmann, A Mark Richards, Chris J Pemberton
CONTEXT: Troponin T upstream open reading frame peptide (TnTuORF) may be useful as a novel biomarker in acute cardiac syndromes. OBJECTIVE: The study examined the early release kinetics of TnTuORF. MATERIALS AND METHODS: We analyzed the time course of the release of cardiac troponins I and T and TnTuORF in patients (n = 31) with hypertrophic obstructive cardiomyopathy undergoing transcoronary ablation of septal hypertrophy (TASH). RESULTS: Fifteen minutes after TASH the levels of both troponins increased significantly (cTnT median: 18 ng/L vs...
October 24, 2016: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
D Mackey, E Kelly, R Nooney
One of the primary considerations in immunoassay design is optimizing the concentration of capture antibody in order to achieve maximal antigen binding and, subsequently, improved sensitivity and limit of detection. Many immunoassay technologies involve immobilization of the antibody to solid surfaces. Antibodies are large molecules in which the position and accessibility of the antigen-binding site depend on their orientation and packing density. In this paper we propose a simple mathematical model, based on the theory known as random sequential adsorption (RSA), in order to calculate how the concentration of correctly oriented antibodies (active site exposed for subsequent reactions) evolves during the deposition process...
December 1, 2016: Mathematical Biosciences and Engineering: MBE
M Oviedo Gutiérrez, S Amat Valero, A Gómez Farpón, C Montalvo Ávalos, L Fernández García, D C Lara Cárdenas, S Barnes Marañón, C Granell Suárez, N Vega Mata, A J López López, M González Guerrero, V Álvarez Muñoz
PURPOSE: Gastrointestinal adenomyoma is a rare benign tumor most frequently located in the stomach. The differential diagnosis is wide because of its large clinical spectrum and unspecific radiological findings. Surgical excision is both diagnostic and therapeutic. CASE REPORT: A 49-days old girl presented with nonbilious vomiting of 48 hours of evolution. Infantile hypertrofic pyloric stenosis was suspected. Ultrasound showed a nonobstructive nodular lesion in the anterior pyloric wall...
April 20, 2016: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
N Albertos Mira-Marcelí, N Gallego Mellado, P Deltell Colomer, J Mira Navarro, A Encinas Goenechea, O Sánchez París, E Liceras Liceras, F González López, M E Martín Hortigüela, C Navarro de la Calzada, J Gonzálvez Piñera
OBJECTIVE: To compare the results of laparoscopic versus open adhesiolysis in children affected by postoperative bowel obstruction. METHODS: Retrospective study reviewing charts of all patients who were operated on due to postoperative adhesions in our Department. Demographic data, clinical characteristics and postoperative data were collected. RESULTS: During the last 8 years, 37 patients were operated on for postoperative intestinal obstructions...
April 20, 2016: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
E Calleja Aguayo, A Moreno Montero, A García Baglietto, A E Hernández Calvarro, J Bregante Ucedo, C Marhuenda Irastorza
OBJECTIVE: The water-soluble contrast has shown its effectiveness for the resolution of adhesive small bowel obstruction (SBO) in adults. The objective of this study is to compare the value of water-soluble contrast in children with SBO versus control group. METHODS: We conducted a case-control trial. Patients with a history of abdominal surgery and SBO diagnosed between 2008 and 2013 were included as controls. Conservative treatment or surgery depending on clinical evolution was performed in control group...
April 20, 2016: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
G Alonso Ciodaro, J I Santamaría Ossorio, S Sanjuán Rodríguez
INTRODUCTION: Cecal duplications are rare, representing 0.4% of all gastrointestinal duplications, with few cases reported in the literature. CLINICAL CASE: A 48 hours-old newborn presented with bilious vomiting and abdominal distension; the ultrasound revealed a cystic mass in the right abdomen; ileocolic resection was performed with end to end anastomosis. Microscopy confirmed cecal duplication cyst. COMMENTS: In patients with intestinal obstruction, contrast enema allows differential diagnosis with other colonic pathologies in the newborn; when the cecal duplication cyst is connected to the lumen of the colon, enema reveals a filling defect, and cecal duplication can be suspected...
October 10, 2016: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
S Castañeda, I Molina, P Jaimes, J Beltrán, J Valero, F Fierro
INTRODUCTION: The aim of the present study was to evaluate clinical presentation and management of sigmoid volvulus in children. Sigmoid volvulus is one of the three leading causes of acute obstruction of the colon and is between 50 and 90% of all large bowel volvulus. In the pediatric population only 3 to 5% of bowel obstructions are caused by volvulus and there are less than 100 cases reported in the literature. The presence of a redundant sigmoid with a narrow mesentery (dolicosigmoide) is a prerequisite for the volvulus formation...
January 15, 2016: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
P Bragagnini Rodríguez, B Stors Sastre, R Fernández Atuan, R Delgado Alvira, M A Rihuete Heras, J Gracia Romero
OBJECTIVE: To evaluate the results of the retroperitoneal-assisted laparoscopic pyeloplasty (RALP) versus the mini posterior lumbotomy pyeloplasty (MPLP). MATERIAL AND METHODS: A retrospective study of 77 patients diagnosed with ureteropelvic junction obstruction between 2007 and 2013 was made, analyzing the surgical technique, complications and results. The anteroposterior pelvic diameter of the kidney, the thickness of the renal parenchyma, the renal function and the morphology of the renogram curve were also evaluated and compared...
January 15, 2016: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
Jihyun Yoon, Hyeyoung Seo, In Hwan Oh, Seok Jun Yoon
In recognition of Korea's rising burden of non-communicable diseases (NCDs), we investigated the nation's NCD status and extracted detailed information from the 2012 Korean Burden of Disease study. Consistent with that study, we used disability-adjusted life year (DALY) as a metric. Using national data sources and disability weights specific to the Korean population, we analyzed 116 disaggregated NCDs from the study's four-level disease and injury hierarchy for both sexes and nine age groups. Per 100,000 population, 21,019 DALYs were lost to 116 NCDs...
November 2016: Journal of Korean Medical Science
Jihyun Yoon, In Hwan Oh, Hyeyoung Seo, Eun Jung Kim, Young Hoon Gong, Minsu Ock, Dohee Lim, Won Kyung Lee, Ye Rin Lee, Dongwoo Kim, Min Woo Jo, Hyesook Park, Seok Jun Yoon
This study is part of a 5-year research project on the national burden of diseases, injuries, and risk factors in Korea. Using disability-adjusted life years (DALYs), a metric introduced by the 1990 Global Burden of Disease (GBD) project, we performed a comprehensive and detailed assessment of the magnitude and distribution of both fatal and non-fatal health problems in the Korean population. The concept and general approach were consistent with the original GBD study, with some methodological modifications to make the study more suitable for Korea...
November 2016: Journal of Korean Medical Science
Stefano Coiro, Nicolas Girerd, Patrick Rossignol, João Pedro Ferreira, Aldo Maggioni, Bertram Pitt, Isabella Tritto, Giuseppe Ambrosio, Kenneth Dickstein, Faiez Zannad
AIMS: To determine the influence of baseline beta-blocker use on long-term prognosis of myocardial infarction (MI) survivors complicated with heart failure (HF) or with left ventricular dysfunction and with history of chronic obstructive pulmonary disease (COPD). METHODS AND RESULTS: Among the 28 771 patients from the High-Risk MI Database Initiative we identified 1573 patients with a baseline history of COPD. We evaluated the association between beta-blocker use at baseline (822 with beta-blocker and 751 without) on the rates of all-cause and cardiovascular mortality...
October 24, 2016: European Journal of Heart Failure
Emmi Helle, Sture Andersson, Unto Häkkinen, Jutta Järvelin, Janne Eskelinen, Eero Kajantie
BACKGROUND: Early term birth is associated with increased need for hospital care during the early postnatal period. The objective of this study was to assess the morbidity and health care-related costs during the first 3 years of life in children born early term. METHODS: Data come from a population-based birth cohort study in the municipalities of Helsinki, Espoo, and Vantaa, Finland using data from the national medical birth register and outpatient, inpatient, and primary care registers...
October 24, 2016: Paediatric and Perinatal Epidemiology
Orso Pusterla, Grzegorz Bauman, Mark O Wielpütz, Sylvia Nyilas, Philipp Latzin, Claus P Heussel, Oliver Bieri
PURPOSE: To introduce a reproducible, nonenhanced 1H MRI method for rapid in vivo functional assessment of the whole lung at 1.5 Tesla (T). METHODS: At different respiratory volumes, the pulmonary signal of ultra-fast steady-state free precession (ufSSFP) follows an adapted sponge model, characterized by a respiratory index α. From the model, α reflects local ventilation-related information, is virtually independent from the lung density and thus from the inspiratory phase and breathing amplitude...
October 23, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
Mahnaz Abbasi, Mohammadali Zohal, Banafsheh Atapour, Zohreh Yazdi
Introduction. Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide. Proper diagnosis of osteoporosis as a systemic adverse effect of COPD is of significant importance. The present study aimed at evaluating the prevalence of osteoporosis and its risk factors in men suffering from COPD in Qazvin (2014). Methods. This descriptive-analytical study was conducted on 90 patients with COPD using random sampling. Anthropometric data and results from physical examination were collected...
2016: International Journal of Chronic Diseases
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