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https://www.readbyqxmd.com/read/28101795/locally-advanced-pancreatic-cancer-successfully-treated-by-distal-pancreatectomy-with-celiac-axis-resection-dp-car-after-s-1-with-radiation-therapy-followed-by-gemcitabine-nab-paclitaxel-therapy-a-case-report
#1
Kyohei Ariake, Fuyuhiko Motoi, Masamichi Mizuma, Keigo Murakami, Tatsuyuki Takadate, Hideo Ohtsuka, Koji Fukase, Kunihiro Masuda, Hiroki Hayashi, Kei Nakagawa, Naoaki Sakata, Takanori Morikawa, Shimpei Maeda, Takeshi Naitoh, Shinichi Egawa, Michiaki Unno
BACKGROUND: The prognosis for pancreatic cancer remains dismal because many patients are diagnosed with unresectable cancer at the initial diagnosis. Recently, conversion surgery was reported as an effective treatment for initially unresectable pancreatic cancer with a favorable response to non-surgical treatment lasting over 240 days. Here, we describe a case of locally advanced pancreatic cancer (LAPC) successfully resected after treatment with S-1 and radiation followed by gemcitabine/nab-paclitaxel therapy...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28100712/salt-management-strategy-defines-the-stem-and-leaf-hydraulic-characteristics-of-six-mangrove-tree-species
#2
Guo-Feng Jiang, Uromi Manage Goodale, Yan-Yan Liu, Guang-You Hao, Kun-Fang Cao
Mangroves in hypersaline coastal habitats are under constant high xylem tension and face great risk of hydraulic dysfunction. To investigate the relationships between functional traits and salt management, we measured 20 hydraulic and photosynthetic traits in four salt-adapted (SA) and two non-SA (NSA) mangrove tree species in south China. The SA species included two salt secretors (SSs), Avicennia marina (Forsskål) Vierhapper and Aegiceras corniculatum (L.) Blanco and two salt excluders (SEs), Bruguiera gymnorrhiza (L...
January 18, 2017: Tree Physiology
https://www.readbyqxmd.com/read/28092203/machine-learning-of-three-dimensional-right-ventricular-motion-enables-outcome-prediction-in-pulmonary-hypertension-a-cardiac-mr-imaging-study
#3
Timothy J W Dawes, Antonio de Marvao, Wenzhe Shi, Tristan Fletcher, Geoffrey M J Watson, John Wharton, Christopher J Rhodes, Luke S G E Howard, J Simon R Gibbs, Daniel Rueckert, Stuart A Cook, Martin R Wilkins, Declan P O'Regan
Purpose To determine if patient survival and mechanisms of right ventricular failure in pulmonary hypertension could be predicted by using supervised machine learning of three-dimensional patterns of systolic cardiac motion. Materials and Methods The study was approved by a research ethics committee, and participants gave written informed consent. Two hundred fifty-six patients (143 women; mean age ± standard deviation, 63 years ± 17) with newly diagnosed pulmonary hypertension underwent cardiac magnetic resonance (MR) imaging, right-sided heart catheterization, and 6-minute walk testing with a median follow-up of 4...
January 16, 2017: Radiology
https://www.readbyqxmd.com/read/28088885/-androgen-receptor-mediated-processes-in-castrate-resistant-metastatic-prostate-cancer
#4
Zsófia Küronya, Krisztina Bíró, Fruzsina Gyergyay, Lajos Géczi
In the past six years, five new drugs have been approved by the FDA for the treatment of metastatic castrate-resistant prostate cancer. While the disease itself still remains incurable, the sequential use of these drugs can significantly prolong survival while maintaining good quality of life. Research from the past decade made it clear that androgen receptor-mediated processes play a central part in the progression of the disease. Hormonal mechanisms related to androgen-receptors can remain active until late stages of the disease...
January 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28088508/relationship-between-central-retinal-vessel-trunk-location-and-visual-field-loss-in-glaucoma
#5
Mengyu Wang, Hui Wang, Louis R Pasquale, Neda Baniasadi, Lucy Q Shen, Peter J Bex, Tobias Elze
PURPOSE: To study the relationship between horizontal central retinal vessel trunk location (CRVTL) on glaucomatous optic discs and sector-specific visual field (VF) loss. DESIGN: Retrospective, cross-sectional study. METHODS: CRVTL of 421 eyes from 421 patients was manually tracked on the horizontal optic disc axis on fundus images. Focal circumpapillary retinal nerve fiber layer thickness (cpRNFLT) measurements were extracted from optical coherence tomography (OCT)...
January 11, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28077829/-development-of-a-psychological-insulin-resistance-scale-for-korean-patients-with-diabetes
#6
Youngshin Song, Younghee Jeon, Jeonghwa Cho, Bohyun Kim
PURPOSE: This study was done to develop and validate a measure to evaluate the Korean version of psychological insulin resistance (K-PIR) in patients with diabetes in Korea. METHODS: Items were initially generated from literature reviews and interviews with 19 patients with diabetes. The content validity of the items was evaluated by experts. Participants were 424 patients with diabetes recruited through convenience sampling. A cross-sectional survey was designed for item-analysis, exploratory factor analysis with principal axis factoring, and confirmatory factor analysis...
December 2016: Journal of Korean Academy of Nursing
https://www.readbyqxmd.com/read/28077499/dynamic-gnrh-and-hcg-testing-establishment-of-new-diagnostic-reference-levels
#7
A Kirstine Bang, Loa Nordkap, Kristian Almstrup, Lærke Priskorn, Jørgen Holm Petersen, Ewa Rajpert-De Meyts, Anna-Maria Andersson, Anders Juul, Niels Joergensen
: 1. OBJECTIVE: Gonadotropin-releasing hormone (GnRH) and Human Chorionic Gonadotropin (hCG) stimulation-tests may be used to evaluate the pituitary and testicular capacity. Our aim was to evaluate changes in follicular-stimulating hormone (FSH), luteinizing hormone (LH) and Testosterone after GnRH and hCG stimulation in healthy men, and assess the impact of six single nucleotide polymorphisms on the responses. 2. DESIGN: GnRH- and hCG-stimulation tests were performed on 77 healthy men, 18-40 years (reference group) at a specialized andrology referral center...
January 11, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28053654/comparison-of-chemical-profiles-and-effectiveness-between-erxian-decoction-and-mixtures-of-decoctions-of-its-individual-herbs-a-novel-approach-for-identification-of-the-standard-chemicals
#8
H P Cheung, S W Wang, T B Ng, Y B Zhang, L X Lao, Z J Zhang, Y Tong, F W S Chung, S C W Sze
BACKGROUND: Identification of bioactive standard chemicals is a major challenge in the study of the Chinese medicinal formula. In particular, the chemical components may interact differently depending on the preparative methods, therefore affecting the amounts of bioactive components and their pharmacological properties in the medicinal formula. With the use of Erxian decoction (EXD) as a study model-a  well-known Chinese medicinal formula for treating menopausal symptoms, a novel and rapid approach in seeking standard chemicals has been established by differentially comparing the HPLC profiles and the menopause-related biochemical parameters of combined decoction of EXD (EXD-C) and mixtures of the decoctions of its individual herbs (EXD-S)...
2017: Chinese Medicine
https://www.readbyqxmd.com/read/28049310/anisotropy-in-geometrically-rough-structure-of-ice-prismatic-plane-interface-during-growth-development-of-a-modified-six-site-model-of-h2o-and-a-molecular-dynamics-simulation
#9
Hiroki Nada
This paper presents a modified version of the six-site model of H2O [H. Nada and J. P. J. M. van der Eerden, J. Chem. Phys. 118, 7401 (2003)]. Although the original six-site model was optimized by assuming the cut-off of the Coulomb interaction at an intermolecular distance of 10 Å, the modified model is optimized by using the Ewald method for estimating the Coulomb interaction. Molecular dynamics (MD) simulations of an ice-water interface suggest that the melting point of ice at 1 atm in the modified model is approximately 274...
December 28, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28048269/su-f-r-12-prediction-of-truebeam-hardware-issues-using-trajectory-log-analysis
#10
D DiCostanzo, A Ayan, J Woollard, N Gupta
PURPOSE: To predict potential failures of hardware within the Varian TrueBeam linear accelerator in order to proactively replace parts and decrease machine downtime. METHODS: Machine downtime is a problem for all radiation oncology departments and vendors. Most often it is the result of unexpected equipment failure, and increased due to lack of in-house clinical engineering support. Preventative maintenance attempts to assuage downtime, but often is ineffective at preemptively preventing many failure modes such as MLC motor failures, the need to tighten a gantry chain, or the replacement of a jaw motor, among other things...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047242/su-f-t-494-a-multi-institutional-study-of-independent-dose-verification-using-golden-beam-data
#11
M Itano, R Tachibana, M Yamashita, H Shimizu, Y Sugawara, K Kotabe, T Kamima, R Takahashi, S Ishibashi, Y Uchida, T Yamazaki, H Tachibana
PURPOSE: In general, beam data of individual linac is measured for independent dose verification software program and the verification is performed as a secondary check. In this study, independent dose verification using golden beam data was compared to that using individual linac's beam data. METHODS: Six institutions were participated and three different beam data were prepared. The one was individual measured data (Original Beam Data, OBD) .The others were generated by all measurements from same linac model (Model-GBD) and all linac models (All-GBD)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047178/th-ab-202-12-the-first-clinical-implementation-of-a-real-time-six-degree-of-freedom-tracking-system-during-radiation-therapy
#12
D Nguyen, J Kim, R O'Brien, C Huang, J Booth, P Greer, K Legge, P Poulsen, J Martin, P Keall
PURPOSE: In current practice, imaging is typically performed prior to treatment; the cancer target motion during treatment is unknown. We present the first clinical implementation of real time Kilovoltage Intrafraction Monitoring (KIM) system which tracks the cancer target translational and rotational motions during treatment. METHODS: KIM technology: KIM estimates the 3D position of the target tumour based on segmented 2D positions of the three implanted fiducials in each of the kV images (125 kV, 10 mA at 11 fps) taken continuously during the treatment arc...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046329/su-f-p-11-long-term-dosimetric-stability-of-6-tomotherapy-systems
#13
J Smilowitz, D Dunkerley, M Geurts, P Hill, P Yadav
PURPOSE: The dosimetric stability of six TomoTherapy units was analyzed to investigate changes in performance over time and with system upgrades. METHODS: Energy and output were tracked using monitor chamber signal, onboard MVCT detector signal and external ion chamber measurements. The systems (and monitoring periods) include 3 Hi-Art (67, 61 and 65 mos.), 2 HDA (29 and 25 mos.) and one research unit (7 mo.). Dose Control Stability system (DCS) was installed on 4 systems...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28043781/the-application-of-physiological-loading-using-a-dynamic-multi-axis-spine-simulator
#14
Timothy Patrick Holsgrove, Anthony W Miles, Sabina Gheduzzi
In-vitro testing protocols used for spine studies should replicate the in-vivo load environment as closely as possible. Unconstrained moments are regularly employed to test spinal specimens in-vitro, but applying such loads dynamically using an active six-axis testing system remains a challenge. The aim of this study was to assess the capability of a custom-developed spine simulator to apply dynamic unconstrained moments with an axial preload. Flexion-extension, lateral bending, and axial rotation were applied to an L5/L6 porcine specimen at 0...
December 30, 2016: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28043749/an-anatomic-analysis-of-mid-anterior-and-anterolateral-approaches-for-hip-arthrocentesis-a%C3%A2-male-cadaveric-study
#15
Jacob D Mikula, Jason M Schon, Chase S Dean, Jorge Chahla, Renato Locks, Alex W Brady, Robert F LaPrade, Marc J Philippon
PURPOSE: To determine the accuracy and safety of non-image-guided modified mid-anterior and anterolateral approaches to the hip joint for arthrocentesis. METHODS: Six pairs (n = 12) of human cadaveric hemipelvises underwent methylene blue hip injections through either a mid-anterior or an anterolateral approach. The distance from the mid-anterior approach to the lateral femoral cutaneous nerve (LFCN) was measured. Needle orientation was defined by a combination of 2 angles, calculated by the computer software analysis of digitized points...
December 30, 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28043038/intra-individual-cortisol-variability-and-low-grade-inflammation-over-10-years-in-older-adults
#16
Heather Herriot, Carsten Wrosch, Jean-Philippe Gouin, Gregory E Miller
OBJECTIVE: This study examined the associations between intra-individual variability in, and inter-individual levels of, diurnal cortisol secretion with a marker of low-grade inflammation (i.e., C-Reactive Protein; CRP). Reasoning that greater day-to-day cortisol variability could reflect a dysregulation of the HPA axis, we hypothesized that it would predict higher levels of CRP, above and beyond inter-individual differences in cortisol levels. METHODS: A 10-year longitudinal study of 130 older adults examined diurnal cortisol secretion on three different days across each of the 6 waves of data collection and levels of CRP during the last 3 waves...
December 21, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28035323/the-role-of-pd-l1-expression-and%C3%A2-intratumoral-lymphocytes-in%C3%A2-response%C3%A2-to-perioperative-chemotherapy%C3%A2-for-urothelial-carcinoma
#17
F Erlmeier, A K Seitz, G Hatzichristodoulou, L Stecher, M Retz, J E Gschwend, W Weichert, H R Kübler, T Horn
Introduction: Immunological pathways are relevant for the effectiveness of conventional cytotoxic chemotherapy. Recently, checkpoint inhibition of the PD-1/PD-L1 axis has been shown to be therapeutically relevant in urothelial carcinoma. Objective: To monitor PD-L1 expression on tumor cells and intratumoral infiltration with CD8 positive lymphocytes during perioperative chemotherapy for urothelial cancer and to evaluate their use as potential predictive markers for chemotherapy. Patients and Methods: Sixty-four patients with muscle-invasive urothelial cancer were included in the analysis...
October 27, 2016: Bladder Cancer
https://www.readbyqxmd.com/read/28030929/risk-exposure-to-vibration-and-noise-in-the-use-of-agricultural-track-laying-tractors
#18
Mariangela Vallone, Filippa Bono, Elisabeth Quendler, Pierluigi Febo, Pietro Catania
Human exposure to mechanical vibration may represent a significant risk factor for exposed workers in the agricultural sector. Also, noise in agriculture is one of the risk factors to be taken into account in the evaluation of workers' health and safety. One of the major sources of discomfort for the workers operating a tractors is the noise to which they are exposed during work. The aim of this study was to evaluate the risk of exposure to whole-body vibration for the operator driving track-laying tractors in vineyard orchard and the noise level...
23, 2016: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/28029028/the-recovery-of-hypothalamic-pituitary-adrenal-axis-is-rapid-in-subclinical-cushing-syndrome
#19
Hee Kyung Kim, Jee Hee Yoon, Yun Ah Jeong, Ho Cheol Kang
BACKGROUND: In subclinical Cushing syndrome (SC), it is assumed that glucocorticoid production is insufficient to cause a clinically recognizable syndrome. Differences in hormonal levels or recovery time of the hypothalamic-pituitary-adrenocortical (HPA) axis after adrenalectomy between patients with overt Cushing syndrome (OC) and SC remain unknown. METHODS: Thirty-six patients (10 with OC and 26 with SC) with adrenal Cushing syndrome who underwent adrenalectomy from 2004 to 2014 were reviewed retrospectively...
December 2016: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28024121/sodium-binding-sites-and-permeation-mechanism-in-the-nachbac-channel-a-molecular-dynamics-study
#20
Carlo Guardiani, P Mark Rodger, Igor A Khovanov
NaChBac was the first discovered sodium voltage dependent channel, yet computational studies are still limited due to the lack of a crystal structure. In this work a pore-only construct built using the NavMs template was investigated using unbiased Molecular Dynamics and Metadynamics. The Potential of Mean Force (PMF) from the unbiased run features four minima, three of which correspond to sites IN, CEN and HFS discovered in NavAb. During the run the Selectivity Filter (SF) is spontaneously occupied by two ions and frequent access of a third one is often observed...
December 26, 2016: Journal of Chemical Theory and Computation
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