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https://www.readbyqxmd.com/read/28214537/biomechanical-behavior-of-endodontically-treated-premolars-using-different-preparation-designs-and-cad-cam-materials
#1
Diogo Pedrollo Lise, Annelies Van Ende, Jan De Munck, Thaís Yumi Umeda Suzuki, Luiz Clovis Cardoso Vieira, Bart Van Meerbeek
OBJECTIVES: To evaluate the effect of restoration design ('2.5-mm deep endocrown', '5-mm deep endocrown' or '5-mm deep post&crown') and CAD/CAM material type (composite or lithium disilicate glass-ceramic) on the load-to-failure of endodontically treated premolars in absence of any ferrule. METHODS: The crowns of 48 single-rooted premolars were cut and the roots were endodontically treated. Teeth were randomly divided into six groups (n=8); teeth in each group were restored using one of the two tested materials with standardized CAD/CAM fabricated endocrowns (with either 2...
February 15, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/28214286/-partial-delegation-to-radiation-therapists-of-the-control-by-cone-beam-ct-of-prostate-positioning
#2
C Benhaïm, G Loos, J L Achard, L Berger, C Caillé, T Frédéric-Moreau, J Biau, M Lapeyre
PURPOSE: Intensity modulated radiotherapy for prostate cancer involves daily monitoring of the positioning of the prostate, possible with cone beam CT (CBCT). It allows increased accuracy compared to readjustments but induces an increase in the time dedicated to these medical checks. The aim of the study was to evaluate the possibility of delegation of this task to the radiation therapists by comparing their readjustments to the doctors. PATIENTS AND METHODS: Five consecutive patients treated with radiation for prostate cancer (76Gy) were analysed...
February 14, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28204898/surgical-treatment-and-outcome-of-tsh-producing-pituitary-adenomas
#3
Roman Rotermund, Nina Riedel, Till Burkhardt, Jakob Matschke, Nils-Ole Schmidt, Jens Aberle, Jörg Flitsch
BACKGROUND: Thyrotropin-producing adenomas (TSHomas) account for approximately 1-2% of all pituitary tumors. Recently, there has been debate on primary treatment as some studies suggest a high rate of hypopituitarism after transsphenoidal surgery and therefore suggest primary use of somatostatin analogs (SSA) instead. We would like to challenge this assumption by presenting our single-center experience with transsphenoidal surgery for TSHoma. METHODS: Fifteen patients treated consecutively between May 2010 and December 2016 were analyzed for long-term postoperative remission and pituitary function...
February 15, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28203482/long-non-coding-rna-h19-induces-cerebral-ischemia-reperfusion-injury-via-activation-of-autophagy
#4
Jue Wang, Bin Cao, Dong Han, Miao Sun, Juan Feng
Long non-coding RNA H19 (lncRNA H19) was found to be upregulated by hypoxia, its expression and function have never been tested in cerebral ischemia and reperfusion (I/R) injury. This study intended to investigate the role of lncRNA H19 and H19 gene variation in cerebral I/R injury with focusing on its relationship with autophagy activation. Cerebral I/R was induced in rats by middle cerebral artery occlusion followed by reperfusion. SH-SY5Y cells were subjected to oxygen and glucose deprivation and reperfusion (OGD/R) to simulate I/R injury...
February 2017: Aging and Disease
https://www.readbyqxmd.com/read/28203363/an-exploratory-factor-analysis-of-the-spontaneous-reporting-of-severe-cutaneous-adverse-reactions
#5
Manfred Hauben, Eric Hung, Wen-Yaw Hsieh
BACKGROUND: Severe cutaneous adverse reactions (SCARs) are prominent in pharmacovigilance (PhV). They have some commonalities such as nonimmediate nature and T-cell mediation and rare overlap syndromes have been documented, most commonly involving acute generalized exanthematous pustulosis (AGEP) and drug rash with eosinophilia and systemic symptoms (DRESS), and DRESS and toxic epidermal necrolysis (TEN). However, they display diverse clinical phenotypes and variations in specific T-cell immune response profiles, plus some specific genotype-phenotype associations...
January 2017: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/28197998/laser-assisted-subepithelial-keratectomy-lasek-versus-laser-assisted-in-situ-keratomileusis-lasik-for-correcting-myopia
#6
REVIEW
Jocelyn Kuryan, Anjum Cheema, Roy S Chuck
BACKGROUND: Near-sightedness, or myopia, is a condition in which light rays entering the eye along the visual axis focus in front of the retina, resulting in blurred vision. Myopia can be treated with spectacles, contact lenses, or refractive surgery. Options for refractive surgery include laser-assisted subepithelial keratectomy (LASEK) and laser-assisted in-situ keratomileusis (LASIK). Both procedures utilize a laser to shape the corneal tissue (front of the eye) to correct refractive error, and both create flaps before laser treatment of corneal stromal tissue...
February 15, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28197877/fasting-leptin-and-glucose-in-normal-weight-over-weight-and-obese-men-and-women-diabetes-patients-with-and-without-clinical-depression
#7
Darakhshan Jabeen Haleem, Shehnaz Sheikh, Asher Fawad, Muhammad A Haleem
A large number of diabetes patients suffer from major depression and are at high risk of mortality. In view of a role of leptin in diabetes, depression and energy homeostasis, the present study concerns circulating levels of leptin in different BMI groups of un-depressed and depressed diabetes patients. Six hundred thirty male and female patients with a primary diagnosis of diabetes were grouped according to BMI and with or without clinical symptoms of depression. Age matched healthy, normal weight male and female volunteers without clinical symptoms of depression or diabetes were taken as controls...
February 15, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28192770/the-relationship-between-childhood-trauma-emotion-recognition-and-irritability-in-schizophrenia-patients
#8
Mustafa Melih Bilgi, Seval Taspinar, Burcu Aksoy, Kaya Oguz, Kerry Coburn, Ali Saffet Gonul
This study investigated the relationship between childhood trauma, irritability, and emotion recognition, in schizophrenia patients during a psychotic break. Thirty-six schizophrenia inpatients and 36 healthy controls were assessed with the Irritability Questionnaire (IRQ) and two facial emotion recognition tasks, the Emotion Discrimination Test (EDT) and Emotion Identification Test (EIT). Patients were further assessed with the Structured Clinical Interview for DSM III-R Axis II Disorders (SCID-II), the Positive and Negative Symptom Scale (PANSS), and the Childhood Trauma Questionnaire-28 (CTQ-28)...
February 3, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28188335/posterior-cruciate-ligament-reconstruction-in-skeletal-immature-children
#9
Ole Gade Sørensen, Peter Faunø, Svend Erik Christiansen, Martin Lind
PURPOSE: Rupture of the posterior cruciate ligament (PCL) is a rare knee injury in children with open growth plates. The follow-up results of six patients with open physes treated with PCL reconstruction are presented. The objective is to evaluate the clinical outcomes of PCL reconstruction for six skeletally immature patients. METHODS: Between 2006 and 2010, six skeletally immature patients were treated with PCL reconstruction. At the time of surgery, the median age was 9 years (range 6-14)...
February 10, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28187201/patient-self-reported-concerns-in-inflammatory-bowel-diseases-a-gender-specific-subjective-quality-of-life-indicator
#10
Valérie Pittet, Carla Vaucher, Florian Froehlich, Bernard Burnand, Pierre Michetti, Michel H Maillard
BACKGROUND: Patient-reported disease perceptions are important components to be considered within a holistic model of quality of care. Gender may have an influence on these perceptions. We aimed to explore gender-specific concerns of patients included in a national bilingual inflammatory bowel disease cohort. METHODS: Following a qualitative study, we built a questionnaire comprising 37 items of concern. Answers were collected on a visual analog scale ranging from 0 to 100...
2017: PloS One
https://www.readbyqxmd.com/read/28186914/design-and-validation-of-a-biofeedback-device-to-improve-heel-to-toe-gait-in-seniors
#11
Abhishek Vadnerkar, Sabrina Figueiredo, Nancy Mayo, Robert Kearney
A feature of healthy human walking gait is a clearly defined heel-strike at initial contact, known as heel-to-toe gait. However, a common consequence of ageing is the deterioration of this heel first gait towards a flat foot, or 'shuffling' gait. This leads to a shortened stride length, slowed gait speed, and an increased fall risk. Shuffling gait is normally treated by physiotherapy, however, therapist time is limited and training is restricted to a clinical environment. Gait rehabilitation could be expedited with the use of a device that distinguishes between heel-to-toe and shuffling gait and gives feedback to the user...
February 7, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28184035/immediate-effects-of-angular-joint-mobilization-a-new-concept-of-joint-mobilization-on-pain-range-of-motion-and-disability-in-a-patient-with-shoulder-adhesive-capsulitis-a-case-report
#12
Younghoon Kim, GyuChang Lee
BACKGROUND Adhesive capsulitis is a common disabling condition, with reviews reporting up to 5.3% of the population being affected, the burden placed upon individuals and healthcare services may therefore be considered substantial. For recovering the normal extensibility of the capsule in individuals with adhesive capsulitis of the shoulder, passive stretching of the capsule through end-range mobilization has been suggested. Recently, the concept of joint mobilization into angular joint mobilization (AJM), which is rotational joint mobilization with joint axis shift, was proposed...
February 10, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28179623/provisional-criteria-for-the-diagnosis-of-hypertension-in-pregnancy-using-home-blood-pressure-measurements
#13
Yukiko Mikami, Yasushi Takai, Sumiko Era, Yoshihisa Ono, Masahiro Saitoh, Kazunori Baba, Hiromichi Suzuki, Hiroyuki Seki
Most guidelines for the management of hypertension define it as a home blood pressure (HBP) value >135/85 mm Hg. However, there is no reference HBP value to diagnose hypertension in pregnant women. Therefore, in this study, we analyzed HBP measurements of pregnant women to determine whether it is appropriate to use the criteria for non-pregnant subjects for pregnant women. The participants of this study were 100 singleton pregnant women who visited our hospital between September 2013 and September 2016...
February 9, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/28177765/diosmin-attenuates-radiation-induced-hepatic-fibrosis-via-boosting-ppar-%C3%AE-expression-and-hampering-mir-17-5p-activated-canonical-wnt-%C3%AE-catenin-signaling
#14
Hesham Farouk Hasan, Mohamed Khairy Abdel-Rafei, Shereen Mohamed Galal
BACKGROUND: Liver fibrosis is one of the major complications of upper right quadrant radiotherapy. MicroRNA-17-5p (miR-17-5p) is hypothesized to act as regulator of hepatic stellate cells (HSCs) activation via activation of canonical Wnt/β-catenin pathway. Diosmin (Dios), a citrus bioflavonoid, is known to possess potent antioxidant, anti-inflammatory and anti-apoptotic properties. PURPOSE: To explore molecular mechanisms underlie radiation- induced liver fibrosis and evaluate the possible influence of Dios on miR-17-5p/ Wnt/ β-catenin signaling axis during fibrogenesis provoked by irradiation (IRR) in rats...
November 21, 2016: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28168068/treatment-challenges-of-a-primary-vertebral-artery-aneurysm-causing-recurrent-ischemic-strokes
#15
Davide Strambo, Luca Peruzzotti-Jametti, Aurora Semerano, Giovanna Fanelli, Franco Simionato, Roberto Chiesa, Enrico Rinaldi, Vittorio Martinelli, Giancarlo Comi, Marco Bacigaluppi, Maria Sessa
Background. Extracranial vertebral artery aneurysms are a rare cause of embolic stroke; surgical and endovascular therapy options are debated and long-term complication may occur. Case Report. A 53-year-old man affected by neurofibromatosis type 1 (NF1) came to our attention for recurrent vertebrobasilar embolic strokes, caused by a primary giant, partially thrombosed, fusiform aneurysm of the left extracranial vertebral artery. The aneurysm was treated by endovascular approach through deposition of Guglielmi Detachable Coils in the proximal segment of the left vertebral artery...
2017: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/28155698/the-biomechanical-significance-of-pulley-on-binocular-vision
#16
Hongmei Guo, Zhipeng Gao, Weiyi Chen
BACKGROUND: Pulleys have been reported as the functional origins of the rectus extraocular muscles (EOMs). However, biomechanical significance of pulleys on binocular vision has not been reported. METHODS: Three eye movement models, i.e., non-pulley model, passive-pulley model, and active-pulley model, are used to simulate the horizontal movement of the eyes from the primary position to the left direction in the range of 1°-30°. The resultant forces of six EOMs along both orthogonal directions (i...
December 28, 2016: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28148662/intra-articular-corrective-osteotomies-combined-with-the-ilizarov-technique-for-the-treatment-of-deformities-of-the-knee
#17
J Xu, Y Jia, Q Kang, Y Chai
AIMS: To present our experience of using a combination of intra-articular osteotomy and external fixation to treat different deformities of the knee. PATIENTS AND METHODS: A total of six patients with a mean age of 26.5 years (15 to 50) with an abnormal hemi-joint line convergence angle (HJLCA) and mechanical axis deviation (MAD) were included. Elevation of a tibial hemiplateau or femoral condylar advancement was performed and limb lengthening with correction of residual deformity using a circular or monolateral Ilizarov frame...
February 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28148279/aberrant-activation-of-hedgehog-signaling-promotes-cell-proliferation-via-the-transcriptional-activation-of-forkhead-box-m1-in-colorectal-cancer-cells
#18
DeJie Wang, Guohui Hu, Ying Du, Cheng Zhang, Quqin Lu, Nonghua Lv, Shiwen Luo
BACKGROUND: Recent evidence suggests that the aberrant activation of Hedgehog (Hh) signaling by Gli transcription factors is characteristic of a variety of aggressive human carcinomas, including colorectal cancer (CRC). Forkhead box M1 (FoxM1) controls the expression of a number of cell cycle regulatory proteins, and FoxM1 expression is elevated in a broad range of human malignancies, which suggests that it plays a crucial role in tumorigenesis. However, the mechanisms underlying FoxM1 expression are not fully understood...
February 2, 2017: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/28144562/grazing-incidence-optical-magnetic-recording-with-super-resolution
#19
Gunther Scheunert, Sidney R Cohen, René Kullock, Ryan McCarron, Katya Rechev, Ifat Kaplan-Ashiri, Ora Bitton, Paul Dawson, Bert Hecht, Dan Oron
Heat-assisted magnetic recording (HAMR) is often considered the next major step in the storage industry: it is predicted to increase the storage capacity, the read/write speed and the data lifetime of future hard disk drives. However, despite more than a decade of development work, the reliability is still a prime concern. Featuring an inherently fragile surface-plasmon resonator as a highly localized heat source, as part of a near-field transducer (NFT), the current industry concepts still fail to deliver drives with sufficient lifetime...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/28139051/positive-parenting-predicts-cortisol-functioning-six-years-later-in-young-adults
#20
Elizabeth A Shirtcliff, Martie L Skinner, Ezemenari M Obasi, Kevin P Haggerty
Research which indicates that adverse experiences influence hypothalamic-pituitary-adrenal (HPA) axis functioning illustrates the social environment 'getting under the skin'. The present study extended this literature by examining whether positive social forces within the caregiving environment can also impact cortisol functioning. We conducted a prospective investigation of over 300 youth, half of whom were White and half were Black. Attachment, bonding and parental rewards for positive behaviors were observed or reported by the youth as an 8th grader...
January 30, 2017: Developmental Science
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