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https://www.readbyqxmd.com/read/28424853/long-term-results-of-ankle-arthrodesis-in-children-and-adolescents-with-haemophilia
#1
Nicolas de l'Escalopier, Alina Badina, Jean Paul Padovani, Annie Harroche, Laurent Frenzel, Philippe Wicart, Christophe Glorion, Chantal Rothschild
INTRODUCTION: Ankle arthrodesis in patients with haemophilia is a joint-non-preserving treatment option often resulting in substantial pain relief and termination of haemarthrosis by osseous consolidating of the joint. However, limited data are available regarding ankle arthrodesis in young patients. AIM: The aim of this study was to evaluate the long-term clinical and radiographic results with a minimum follow-up of ten years in children with haemophilia who underwent ankle arthrodesis...
April 20, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28418336/intracranial-lesions-in-children-and-adolescents-with-morbid-obesity
#2
Ayça Törel Ergür, Sevinç Odabaşı Güneş, Sinan Tan, Ü Ayşe Tandırcıoğlu
BACKGROUND: Intracranial lesions may affect the hypothalamo-hypophyseal axis and lead to some neuro-endocrinological dysfunctions (hyperphagia, sleep disorders and hormonal dysfunctions). There is a very limited number of studies about childhood obesity and intracranial lesions. AIMS: To evaluate the incidence of intracranial lesions and its role in clinical symptoms and aetiology in cases with morbid obesity who have been admitted to the paediatric endocrinology department with this complaint...
April 5, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28418098/stress-and-subsidy-effects-of-seagrass-wrack-duration-frequency-and-magnitude-on-salt-marsh-community-structure
#3
Torrance C Hanley, David L Kimbro, A Randall Hughes
Environmental perturbations can strongly affect community processes and ecosystem functions by acting primarily as a subsidy that increases productivity, a stress that decreases productivity, or both, with the predominant effect potentially shifting from subsidy to stress as the overall intensity of the perturbation increases. While perturbations are often considered along a single axis of intensity, they consist of multiple components (e.g., magnitude, frequency, and duration) that may not have equivalent stress and/or subsidy effects...
April 18, 2017: Ecology
https://www.readbyqxmd.com/read/28405504/pd-l1-cd274-copy-number-gain-expression-and-immune-cell-infiltration-as-candidate-predictors-for-response-to-immune-checkpoint-inhibitors-in-soft-tissue-sarcoma
#4
Jan Budczies, Gunhild Mechtersheimer, Carsten Denkert, Frederick Klauschen, Sadaf S Mughal, Priya Chudasama, Michael Bockmayr, Korinna Jöhrens, Volker Endris, Amelie Lier, Felix Lasitschka, Roland Penzel, Manfred Dietel, Benedikt Brors, Stefan Gröschel, Hanno Glimm, Peter Schirmacher, Marcus Renner, Stefan Fröhling, Albrecht Stenzinger
Soft-tissue sarcomas (STS) are rare malignancies that account for 1% of adult cancers and comprise more than 50 entities. Current therapeutic options for advanced-stage STS are limited. Immune checkpoint inhibitors targeting the PD-1/PD-L1 signaling axis are being explored as new treatment modality in STS; however, the determinants of response to these agents are largely unknown. Using the sarcoma data set of The Cancer Genome Altas (TCGA) and an independent cohort of untreated high-grade STS, we analyzed DNA copy number status and mRNA expression of PD-L1 in a total of 335 STS cases...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28399260/the-plant-economics-spectrum-is-structured-by-leaf-habits-and-growth-forms-across-subtropical-species
#5
Yan-Tao Zhao, Arshad Ali, En-Rong Yan
The plant economics spectrum that integrates the combination of leaf and wood syndromes provides a useful framework for the examination of species strategies at the whole-plant level. However, it remains unclear how species that differ in leaf habits and growth forms are integrated within the plant economics spectrum in subtropical forests. We measured five leaf and six wood traits across 58 subtropical plant species, which represented two leaf habits (evergreen vs deciduous) and two growth forms (tree vs shrub) in eastern China...
February 1, 2017: Tree Physiology
https://www.readbyqxmd.com/read/28380896/circularly-polarized-hankel-vortices
#6
Victor V Kotlyar, Alexey A Kovalev
We discuss vector Hankel beams with circular polarization. These beams appear as a generalization of a spherical wave with an embedded optical vortex with topological charge n. Explicit analytical relations to describe all six projections of the E- and H-field are derived. The relations are shown to satisfy Maxwell's equations. Hankel beams with clockwise and anticlockwise circular polarization are shown to have peculiar features while propagating in free space. Relations for the Poynting vector projections and the angular momentum in the far field are also obtained...
April 3, 2017: Optics Express
https://www.readbyqxmd.com/read/28377644/finite-element-analysis-of-sagittal-balance-in-different-morphotype-forces-and-resulting-strain-in-pelvis-and-spine
#7
REVIEW
Vincenzo Filardi, Portaro Simona, Giorgio Cacciola, Salvatore Bertino, Luigi Soliera, Andrea Barbanera, Alessandro Pisani, Demetrio Milardi, Bramanti Alessia
In humans, vertical posture acquisition caused several changes in bones and muscles which can be assumed as verticalization. Pelvis, femur, and vertebral column gain an extension position which decreases muscular work by paravertebral muscles in the latter. It's widely known that six different morphological categories exist; each category differs from the others by pelvic parameters and vertebral column curvatures. Both values depend on the Pelvic Incidence, calculated as the angle between the axes passing through the rotation centre of the two femur heads and the vertical axis passing through the superior plate of the sacrum...
June 2017: Journal of Orthopaedics
https://www.readbyqxmd.com/read/28367956/study-on-the-short-term-effects-of-increased-alcohol-and-cigarette-consumption-in-healthy-young-men-s-seminal-quality
#8
Joana Vieira Silva, Daniel Cruz, Mariana Gomes, Bárbara Regadas Correia, Maria João Freitas, Luís Sousa, Vladimiro Silva, Margarida Fardilha
Many studies have reported a negative impact of lifestyle factors on testicular function, spermatozoa parameters and pituitary-gonadal axis. However, conclusions are difficult to draw, since studies in the general population are rare. In this study we intended to address the early and late short-term impact of acute lifestyle alterations on young men's reproductive function. Thirty-six healthy male students, who attended the Portuguese academic festivities, provided semen samples and answered questionnaires at three time-points...
April 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28361018/spinal-alignment-evolution-with-age-a-prospective-gait-analysis-study
#9
Sébastien Pesenti, Benjamin Blondel, Emilie Peltier, Elke Viehweger, Vincent Pomero, Guillaume Authier, Stéphane Fuentes, Jean-Luc Jouve
AIM: To describe, using gait analysis, the development of spinal motion in the growing child. METHODS: Thirty-six healthy children aged from 3 to 16 years old were included in this study for a gait analysis (9 m-walk). Various kinematic parameters were recorded and analyzed such as thoracic angle (TA), lumbar angle (LA) and sagittal vertical axis (SVA). The kinetic parameters were the net reaction moments (N.m/kg) at the thoracolumbar and lumbosacral junctions. RESULTS: TA and LA curves were not statistically correlated to the age (respectively, P = 0...
March 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/28357825/the-prevalence-of-electrocardiogram-abnormalities-in-professional-divers
#10
Ali Erdal Gunes, Maide Cimsit
BACKGROUND: The underwater environment presents physiological challenges for the cardiovascular, renal and pulmonary systems. Increases in external hydrostatic pressure reduce the capacity of the venous compartment and cause blood to move toward the lung. The aim of this study was to evaluate retrospectively electrocardiographic (ECG) changes in a cohort of professional divers. METHODS: Between January 2009 and January 2012, 225 randomly selected professional divers, 204 male (91%) and 21 female (9%) attended our clinic for their biannual diving medical assessment...
March 2017: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
https://www.readbyqxmd.com/read/28350324/investigation-on-inter-limb-coordination-and-motion-stability-intensity-and-complexity-of-trunk-and-limbs-during-hands-knees-crawling-in-human-adults
#11
Shenglan Ma, Xiang Chen, Shuai Cao, Yi Yu, Xu Zhang
This study aimed to investigate the inter-limb coordination pattern and the stability, intensity, and complexity of the trunk and limbs motions in human crawling under different speeds. Thirty healthy human adults finished hands-knees crawling trials on a treadmill at six different speeds (from 1 km/h to 2.5 km/h). A home-made multi-channel acquisition system consisting of five 3-axis accelerometers (ACC) and four force sensors was used for the data collection. Ipsilateral phase lag was used to represent inter-limb coordination pattern during crawling and power, harmonic ratio, and sample entropy of acceleration signals were adopted to depict the motion intensity, stability, and complexity of trunk and limbs respectively...
March 28, 2017: Sensors
https://www.readbyqxmd.com/read/28349911/evaluation-of-soft-tissue-landmark-reliability-between-manual-and-computerized-plotting-methods
#12
Geetha Kasinathan, Pradeep B Kommi, Senthil M Kumar, Aniruddh Yashwant, Nandakumar Arani, Senkutvan Sabapathy
AIM: The aim of the study is to evaluate the reliability of soft tissue landmark identification between manual and digital plot-tings in both X and Y axes. MATERIALS AND METHODS: A total of 50 pretreatment lateral cephalograms were selected from patients who reported for orthodontic treatment. The digital images of each cephalogram were imported directly into Dolphin software for onscreen digi-talization, while for manual tracing, images were printed using a compatible X-ray printer...
April 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28347252/the-critical-role-and-potential-target-of-the-autotaxin-lysophosphatidate-axis-in-pancreatic-cancer
#13
REVIEW
Ming Quan, Jiu-Jie Cui, Xiao Feng, Qian Huang
Autotaxin, an ecto-lysophospholipase D encoded by the human ENNP2 gene, is expressed in multiple tissues, and participates in numerous critical physiologic and pathologic processes including inflammation, pain, obesity, embryo development, and cancer via the generation of the bioactive lipid lysophosphatidate. Overwhelming evidences indicate that the autotaxin/lysophosphatidate signaling axis serves key roles in the numerous processes central to tumorigenesis and progression, including proliferation, survival, migration, invasion, metastasis, cancer stem cell, tumor microenvironment, and treatment resistance by interacting with a series of at least six G-protein-coupled receptors (LPAR1-6)...
March 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28343302/force-assisted-ultrasound-imaging-system-through-dual-force-sensing-and-admittance-robot-control
#14
Ting-Yun Fang, Haichong K Zhang, Rodolfo Finocchi, Russell H Taylor, Emad M Boctor
PURPOSE: Ultrasound imaging has been a gold standard for clinical diagnoses due to its unique advantages compared to other imaging modalities including: low cost, noninvasiveness, and safeness to the human body. However, the ultrasound scanning process requires applying a large force over extended periods of time, often in uncomfortable postures in order to maintain the desired orientation. This physical requirement over sonographers' careers often leads to musculoskeletal pain and strain injuries...
March 25, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28341914/the-injury-tolerance-of-the-tibia-under-off-axis-impact-loading
#15
Avery B Chakravarty, Alberto A Martinez, Cheryl E Quenneville
During a frontal collision, there are a range of lower extremity postures that the vehicle's occupant may assume, potentially changing the way load is transmitted to this region of the body. While most experimental studies on the tibia's injury tolerance assume that load is directed along the leg's long axis, the effects of off-axis loading due to non-standard postures have not been well quantified, and commonly-cited injury criteria such as the Tibia Index do not directly account for posture. Therefore, twelve cadaveric tibias (paired from six donors) were subjected to off-axis impact loading in a custom-built test apparatus...
March 24, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28330718/adult-glucocorticoid-receptor-mrna-expression-volatility-in-response-to-an-acute-stressor-and-juvenile-csf-corticotropin-releasing-factor-a-pilot-neurodevelopmental-study
#16
Shariful A Syed, Eric L P Smith, Olcay Batuman, Leonard A Rosenblum, Michael J Owens, Charles B Nemeroff, Jeremy D Coplan
INTRODUCTION: Early life stress (ELS) has been shown to play a role in establishing persistent maladaptive HPA axis modifications that may contribute to the pathogenesis of mood and anxiety disorders. Central glucocorticoid receptor (GR) messenger RNA (mRNA) expression may facilitate (mal)adaptive responsivity to ELS. The role of adult monocytic GR mRNA expression, a putative CNS proxy, during acute stress exposure was explored as well as the ELS marker, juvenile cerebrospinal fluid (CSF) corticotropin-releasing factor...
March 19, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28319591/psychopathological-assessment-of-risk-of-restraint-in-acute-psychiatric-patients
#17
Federico Dazzi, Lorenzo Tarsitani, Michele Di Nunzio, Valeria Trincia, Gabriella Scifoni, Giuseppe Ducci
The study aims to identify independent predictors of physical restraint in acute psychiatric patients and to determine the predictive power of a risk assessment model centered on psychopathological dimensions. We included 1552 patients admitted to a psychiatric intensive care unit over a 5-year period. Patients were rated on the Brief Psychiatric Rating Scale (BPRS-E) at admission. Principal axis factoring (PAF) with varimax rotation was performed on BPRS-E items to identify psychopathological factors. Multiple logistic regression analysis was performed...
March 18, 2017: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/28318521/teaching-the-basics-of-echocardiography-in-the-undergraduate-students-as-mentors
#18
A Arias Felipe, J Doménech García, I Sánchez Los Arcos, D Luordo, F J García Sánchez, J Villanueva Martínez, A Forero de la Sotilla, V Villena Garrido, J Torres Macho, G García de Casasola Sánchez
OBJECTIVE: To analyse the ability of medical students to incorporate the practical teaching of basic echocardiography planes using a peer mentoring design. METHODOLOGY: Thirty-six medical students previously trained in obtaining echocardiography planes (mentors) taught the other 5th-year students (n=126). The teaching methodology included three stages: theory (online course), basic training (three 15h sessions of practical experience in ultrasound and at least 20 echocardiographic studies per mentor) and objective structured clinical assessment (OSCA), which scored the appropriateness of the basic ultrasound planes and the correct identification of 16 cardiac structures...
March 15, 2017: Revista Clínica Española
https://www.readbyqxmd.com/read/28318162/-inclination-of-crown-and-tooth-longitudinal-axis-in-cephalometric-analysis-of-normal-occlusions
#19
Liu Xu, Ren Jing, Yang Xianrui, Wang Li
OBJECTIVE: We measured and analyzed the angle between the longitudinal axis of incisor crown and tooth to provide a reference for orthodontists for selecting orthodontic methods and evaluating treatment results. METHODS: A total of 120 participants were included according to the criteria of Andrews' six keys, and cephalometric radiograph under the instructions of modified natural head position acquirement method was performed. The angles of maxillary incisor crown longitudinal axis, tooth longitudinal axis, occlusion plane (OP), and true vertical (TV) plane were measured, as well as mandibular incisors...
December 1, 2016: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28314520/interaction-between-postural-asymmetry-and-visual-feedback-effects-in-undisturbed-upright-stance-control-in-healthy-adults
#20
Patrice R Rougier, Samir Boudrahem
OBJECTIVES: The technique of additional visual feedback has been shown to significantly decrease the center of pressure (CP) displacements of a standing subject. Body-weight asymmetry is known to increase postural instability due to difficulties in coordinating the reaction forces exerted under each foot and is often a cardinal feature of various neurological and traumatic diseases. To examine the possible interactions between additional visual feedback and body-weight asymmetry effects, healthy adults were recruited in a protocol with and without additional visual feedback, with different levels of body-weight asymmetry...
March 14, 2017: Neurophysiologie Clinique, Clinical Neurophysiology
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