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https://www.readbyqxmd.com/read/29046628/the-human-periallocortex-layer-pattern-in-presubiculum-parasubiculum-and-entorhinal-cortex-a-review
#1
REVIEW
Ricardo Insausti, Mónica Muñoz-López, Ana M Insausti, Emilio Artacho-Pérula
The cortical mantle is not homogeneous, so that three types of cortex can be distinguished: allocortex, periallocortex and isocortex. The main distinction among those three types is based on morphological differences, in particular the number of layers, overall organization, appearance, etc., as well as its connectivity. Additionally, in the phylogenetic scale, this classification is conserved among different mammals. The most primitive and simple cortex is the allocortex, which is characterized by the presence of three layers, with one cellular main layer; it is continued by the periallocortex, which presents six layers, although with enough differences in the layer pattern to separate three different fields: presubiculum (PrS), parasubiculum (PaS), and entorhinal cortex (EC)...
2017: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/29041862/impact-of-chronic-maternal-stress-during-early-gestation-on-maternal-fetal-stress-transfer-and-fetal-stress-sensitivity-in-sheep
#2
Michelle Dreiling, Rene Schiffner, Sabine Bischoff, Sven Rupprecht, Nasim Kroegel, Harald Schubert, Otto W Witte, Matthias Schwab, Florian Rakers
Acute stress-induced reduction of uterine blood flow (UBF) is an indirect mechanism of maternal-fetal stress transfer during late gestation. Effects of chronic psychosocial maternal stress (CMS) during early gestation, as may be experienced by many working women, on this stress signaling mechanism are unclear. We hypothesized that CMS in sheep during early gestation augments later acute stress-induced decreases of UBF, and aggravates the fetal hormonal, cardiovascular, and metabolic stress responses during later development...
October 18, 2017: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/29038805/-switching-on-the-single-molecule-magnet-properties-within-a-series-of-dinuclear-cobalt-iii-dysprosium-iii-2-pyridyloximate-complexes
#3
C D Polyzou, E S Koumousi, Z G Lada, C P Raptopoulou, V Psycharis, M Rouzières, A C Tsipis, C Mathonière, R Clérac, S P Perlepes
The use of 2-pyridinealdoxime (paoH), methyl 2-pyridyl ketone oxime (mepaoH), phenyl 2-pyridyl ketone oxime (phpaoH) and pyridine-2-amidoxime (NH2paoH) for the synthesis of dinuclear Co(III)/Dy(III) complexes is described in the absence or presence of an external base. Complexes [CoDy(pao)3(NO3)3] (1), [CoDy(mepao)3(NO3)3] (2), [CoDy(phpao)3(NO3)3] (3) and [CoDy(NH2pao)3(NO3)3]·3MeOH (4·3MeOH) have been isolated and their structures have been determined by single-crystal X-ray crystallography. The complexes crystallize in non-centrosymmetric (2, 3) or centrosymmetric (1, 4·3MeOH) trigonal space groups and form a family of triply-oximate bridged dinuclear Co(iii)-Dy(iii) complexes...
October 17, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29038331/ghrelin-stimulation-by-hypothalamo-pituitary-adrenal-axis-activation-depends-on-increasing-cortisol-levels
#4
Ibrahim Azzam, Susan Gilad, Rona Limor, Naftali Stern, Yona Greenman
Ghrelin plasma concentration increases in parallel to cortisol after a standardized psychological stress in humans, but the physiological basis of this interaction is unknown. We aimed to elucidate this question by studying the ghrelin response to pharmacological manipulation of the hypothalamo-pituitary-adrenal (HPA) axis. Six lean, healthy male volunteers were examined under four experimental conditions. Blood samples were collected every 30 minutes for two sequential periods of two hours. Initially, a baseline period was followed by intravenous injection of a synthetic analog of ACTH (250 μg)...
October 16, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/29037095/biological-dose-and-complication-probabilities-for-the-rectum-and-bladder-based-on-linear-energy-transfer-distributions-in-spot-scanning-proton-therapy-of-prostate-cancer
#5
Jesper Pedersen, Jørgen B B Petersen, Camilla H Stokkevåg, Kristian S Ytre-Hauge, Stella Flampouri, Zuofeng Li, Nancy Mendenhall, Ludvig P Muren
BACKGROUND: The increased linear energy transfer (LET) at the end of the Bragg peak causes concern for an elevated and spatially varying relative biological effectiveness (RBE) of proton therapy (PT), often in or close to dose-limiting normal tissues. In this study, we investigated dose-averaged LET (LETd) distributions for spot scanning PT of prostate cancer patients using different beam angle configurations. In addition, we derived RBE-weighted (RBEw) dose distributions and related normal tissue complication probabilities (NTCPs) for the rectum and bladder...
October 17, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29035615/improving-mobility-performance-in-wheelchair-basketball
#6
Thom T J Veeger, Annemarie M H De Witte, Monique A M Berger, Rienk M A Van Der Slikke, Dirkjan H E J Veeger, Marco J M Hoozemans
OBJECTIVE: This study aimed to investigate which characteristics of athlete, wheelchair and athlete-wheelchair interface are the best predictors of wheelchair basketball mobility performance. DESIGN: Sixty experienced wheelchair basketball players performed a wheelchair mobility performance test to assess their mobility performance. To determine which variables were the best predictors of mobility performance, forward stepwise linear regression analyses were performed on a set of 33 characteristics, including ten athlete, nineteen wheelchair and four athlete-wheelchair interface characteristics...
October 16, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/29027984/the-effect-of-intra-articular-injection-of-autologous-microfragmented-fat-tissue-on-proteoglycan-synthesis-in-patients-with-knee-osteoarthritis
#7
Damir Hudetz, Igor Borić, Eduard Rod, Željko Jeleč, Andrej Radić, Trpimir Vrdoljak, Andrea Skelin, Gordan Lauc, Irena Trbojević-Akmačić, Mihovil Plečko, Ozren Polašek, Dragan Primorac
Osteoarthritis (OA) is one of the leading musculoskeletal disorders in the adult population. It is associated with cartilage damage triggered by the deterioration of the extracellular matrix tissue. The present study explores the effect of intra-articular injection of autologous microfragmented adipose tissue to host chondrocytes and cartilage proteoglycans in patients with knee OA. A prospective, non-randomized, interventional, single-center, open-label clinical trial was conducted from January 2016 to April 2017...
October 13, 2017: Genes
https://www.readbyqxmd.com/read/29020053/method-for-measuring-tri-axial-lumbar-motion-angles-using-wearable-sheet-stretch-sensors
#8
Akio Yamamoto, Hiroyuki Nakamoto, Tokiya Yamaji, Hideo Ootaka, Yusuke Bessho, Ryo Nakamura, Rei Ono
BACKGROUND: Body movements, such as trunk flexion and rotation, are risk factors for low back pain in occupational settings, especially in healthcare workers. Wearable motion capture systems are potentially useful to monitor lower back movement in healthcare workers to help avoid the risk factors. In this study, we propose a novel system using sheet stretch sensors and investigate the system validity for estimating lower back movement. METHODS: Six volunteers (female:male = 1:1, mean age: 24...
2017: PloS One
https://www.readbyqxmd.com/read/29017215/-pulmonary-embolism-despite-rivaroxaban-in-an-obese-patient
#9
Thomas Schuh, Claudia Stöllberger
Introduction Rivaroxaban, an oral factor Xa inhibitor, is approved for therapy of venous thromboembolism. It is unclear whether the standard dose for patients with a body mass index (BMI) > 40 kg/m(2) is sufficient. History The 45-year-old patient was admitted because of increasing respiratory distress. She had a history of pulmonary embolism 30 months before the admission, a factor V Leiden mutation and several hospitalisations due to dermatomycoses. The patient briefly took phenprocoumon which was changed to 20 mg rivaroxaban due to a lack of adherence...
October 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28994413/flexed8-the-first-member-of-a-fast-and-flexible-sample-changer-family-for-macromolecular-crystallography
#10
Gergely Papp, Franck Felisaz, Clement Sorez, Marcos Lopez-Marrero, Robert Janocha, Babu Manjasetty, Alexandre Gobbo, Hassan Belrhali, Matthew W Bowler, Florent Cipriani
Automated sample changers are now standard equipment for modern macromolecular crystallography synchrotron beamlines. Nevertheless, most are only compatible with a single type of sample holder and puck. Recent work aimed at reducing sample-handling efforts and crystal-alignment times at beamlines has resulted in a new generation of compact and precise sample holders for cryocrystallography: miniSPINE and NewPin [see the companion paper by Papp et al. (2017, Acta Cryst., D73, 829-840)]. With full data collection now possible within seconds at most advanced beamlines, and future fourth-generation synchrotron sources promising to extract data in a few tens of milliseconds, the time taken to mount and centre a sample is rate-limiting...
October 1, 2017: Acta Crystallographica. Section D, Structural Biology
https://www.readbyqxmd.com/read/28984032/effects-of-dietary-selenium-and-moisture-on-the-physical-activity-and-thyroid-axis-of-cats
#11
S E Hooper, R Backus, S Amelon
Consumption of canned cat food is considered a risk factor for the development of feline hyperthyroidism. Because selenium and water are substantially higher in canned diets compared to dry diets, objectives of this study were to determine whether increased dietary selenium or water alters the function of the hypothalamic-pituitary-thyroid axis and leads to an increase in activity level. Employing a 28-day latin square design with a 14-day washout, six lean, neutered male domestic shorthair cats were fed (i) commercially available adult dry feline diet containing 0...
October 6, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28978790/isomorphous-rare-earth-bis-bis-2-6-diisopropylphenyl-phosphate-complexes-and-their-self-assembly-into-two-dimensional-frameworks-by-intramolecular-hydrogen-bonds
#12
Mikhail E Minyaev, Ilya E Nifant'ev, Alexander N Tavtorkin, Sof'ya A Korchagina, Shadana Sh Zeynalova, Ivan V Ananyev, Andrei V Churakov
The crystal structures of rare-earth diaryl- or dialkylphosphate derivatives are poorly explored. Crystals of bis[bis(2,6-diisopropylphenyl)phosphato-κO]chloridotetrakis(methanol-κO)neodymium methanol disolvate, [Nd(C24H34O4P)Cl(CH4O)4]·2CH3OH, (1), and of the lutetium, [Lu(C24H34O4P)Cl(CH4O)4]·2CH3OH, (2), and yttrium, [Y(C24H34O4P)Cl(CH4O)4]·2CH3OH, (3), analogues have been obtained by reactions between lithium bis(2,6-diisopropylphenyl)phosphate and LnCl3(H2O)6 (in a 2:1 ratio) in methanol. Compounds (1)-(3) crystallize in the C2/c space group...
October 1, 2017: Acta Crystallographica. Section C, Structural Chemistry
https://www.readbyqxmd.com/read/28978719/pharmacological-dual-inhibition-of-tumor-and-tumor-induced-functional-limitations-in-transgenic-model-of-breast-cancer
#13
Ruizhong Wang, Poornima Bhat-Nakshatri, Maria B Padua, Mayuri S Prasad, Manjushree Anjanappa, Max Jacobson, Courtney Finnearty, Victoria Sefcsik, Kyle McElyea, Rachael Redmond, George E Sandusky, Narsimha Penthala, Peter A Crooks, Jianguo Liu, Teresa Zimmers, Harikrishna Nakshatri
Breast cancer progression is associated with systemic effects including functional limitations and sarcopenia without the appearance of overt cachexia. Autocrine/paracrine actions of cytokines/chemokines produced by cancer cells mediate cancer progression and functional limitations. The cytokine-inducible transcription factor NF-κB could be central to this process, as it displays oncogenic functions and is integral to the Pax7:MyoD:Pgc-1β:miR-486 myogenesis axis. We tested this possibility using the MMTV-PyMT transgenic mammary tumor model and the NF-κB inhibitor dimethylaminoparthenolide (DMAPT)...
October 4, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28977056/electrocardiographic-findings-in-brazilian-adults-without-heart-disease-elsa-brasil
#14
Marcelo Martins Pinto, Luisa C C Brant, José Luiz Padilha-da-Silva, Murilo Foppa, Paulo A Lotufo, José Geraldo Mill, Paulo R Vasconcelo-Silva, Maria da Conceição C Almeida, Sandhi Maria Barreto, Antônio Luiz Pinho Ribeiro
BACKGROUND: The electrocardiogram (ECG) is widely used in population-based studies. However, there are few studies on electrocardiographic findings in Latin America and in Brazil. The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) comprised 15,105 participants (35-74 years) from six Brazilian capitals. OBJECTIVES: To describe electrocardiographic findings in Brazilian adults without heart disease, stratified by sex, age and race/skin color. METHODS: Cross-sectional study with baseline data of 11,094 adults (44...
October 2, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28971520/isotropic-3d-cardiac-cine-mri-allows-efficient-sparse-segmentation-strategies-based-on-3d-surface-reconstruction
#15
Freddy Odille, Aurélien Bustin, Shufang Liu, Bailiang Chen, Pierre-André Vuissoz, Jacques Felblinger, Laurent Bonnemains
PURPOSE: Segmentation of cardiac cine MRI data is routinely used for the volumetric analysis of cardiac function. Conventionally, 2D contours are drawn on short-axis (SAX) image stacks with relatively thick slices (typically 8 mm). Here, an acquisition/reconstruction strategy is used for obtaining isotropic 3D cine datasets; reformatted slices are then used to optimize the manual segmentation workflow. METHODS: Isotropic 3D cine datasets were obtained from multiple 2D cine stacks (acquired during free-breathing in SAX and long-axis (LAX) orientations) using nonrigid motion correction (cine-GRICS method) and super-resolution...
October 2, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28969160/anti-alzheimer-properties-of-probiotic-lactobacillus-plantarum-mtcc-1325-in-alzheimer-s-disease-induced-albino-rats
#16
Mallikarjuna Nimgampalle, Yellamma Kuna
INTRODUCTION: Alzheimer's disease is a type of dementia, and till now there is no suitable drug available for the complete cure of this disease. Now-a-days Probiotics, Lactobacillus strains play a therapeutic role in cognitive disorders through Gut-Brain Axis communication. AIM: The present study was aimed to evaluate the anti-Alzheimer properties of Lactobacillus plantarum MTCC1325 against D-Galactose-induced Alzheimer's disease in albino rats. MATERIALS AND METHODS: Healthy rats (48) of wistar strain were divided into four groups viz...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28963986/a-systematic-review-of-allostatic-load-in-relation-to-socioeconomic-position-poor-fidelity-and-major-inconsistencies-in-biomarkers-employed
#17
REVIEW
Sarah C Johnson, Francesca L Cavallaro, David A Leon
BACKGROUND: The association between disease and socioeconomic position (SEP) is well established. Allostatic load (AL), or physiological 'wear and tear', is a concept that aims to elucidate the biological consequences of stress that may underlie these associations. The primary objective of this paper is to review the biomarkers and methods used to operationalise the concept of AL in studies analysing the association between AL and SEP. METHODS: Four databases (Embase, Global Health, MEDLINE, and PsychINFO) were searched using terms related to AL, biomarkers and SEP...
September 19, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28961209/error-modeling-and-experimental-study-of-a-flexible-joint-6-upur-parallel-six-axis-force-sensor
#18
Yanzhi Zhao, Yachao Cao, Caifeng Zhang, Dan Zhang, Jie Zhang
By combining a parallel mechanism with integrated flexible joints, a large measurement range and high accuracy sensor is realized. However, the main errors of the sensor involve not only assembly errors, but also deformation errors of its flexible leg. Based on a flexible joint 6-UPUR (a kind of mechanism configuration where U-universal joint, P-prismatic joint, R-revolute joint) parallel six-axis force sensor developed during the prephase, assembly and deformation error modeling and analysis of the resulting sensors with a large measurement range and high accuracy are made in this paper...
September 29, 2017: Sensors
https://www.readbyqxmd.com/read/28953661/comparison-of-kinematic-and-mechanical-alignment-techniques-in-primary-total-knee-arthroplasty-a-meta-analysis
#19
Jung-Ro Yoon, Seung-Beom Han, Min-Kyo Jee, Young-Soo Shin
BACKGROUND: This meta-analysis compared clinical and radiographic outcomes and complications of kinematic alignment (KA) and mechanical alignment (MA) techniques in primary total knee arthroplasty (TKA). METHODS: All studies comparing the operation time, change in hemoglobin, length of hospital stay, postoperative complications, and clinical and radiographic outcomes as assessed with various measurement tools, from direct interview to imaging methods, in patients who underwent primary TKA through the KA or MA technique were included...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28953492/descemet-membrane-endothelial-keratoplasty-in-eyes-with-previous-laser-refractive-surgery-outcomes-and-complications
#20
Dorian A Zeidenweber, Zachary M Mayko, Michael D Straiko, Mark A Terry
PURPOSE: To evaluate the refractive predictability and efficacy of Descemet membrane endothelial keratoplasty (DMEK) for patients with previous laser refractive surgery. METHODS: We retrospectively reviewed our cohort of endothelial keratoplasty surgical cases. We identified 21 eyes that underwent laser-assisted in situ keratomileusis (n = 17) or photorefractive keratectomy (n = 4) and were treated with DMEK for endothelial failure. Patients were analyzed preoperatively and at 6 months postoperatively for changes in visual acuity, refraction, and corneal topography...
November 2017: Cornea
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