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https://www.readbyqxmd.com/read/28330718/adult-glucocorticoid-receptor-mrna-expression-volatility-in-response-to-an-acute-stressor-and-juvenile-csf-corticotropin-releasing-factor-a-pilot-neurodevelopmental-study
#1
Shariful A Syed, Eric L P Smith, Olcay Batuman, Leonard A Rosenblum, Michael J Owens, Charles B Nemeroff, Jeremy D Coplan
INTRODUCTION: Early life stress (ELS) has been shown to play a role in establishing persistent maladaptive HPA axis modifications that may contribute to the pathogenesis of mood and anxiety disorders. Central glucocorticoid receptor (GR) messenger RNA (mRNA) expression may facilitate (mal)adaptive responsivity to ELS. The role of adult monocytic GR mRNA expression, a putative CNS proxy, during acute stress exposure was explored as well as the ELS marker, juvenile cerebrospinal fluid (CSF) corticotropin-releasing factor...
March 19, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28319591/psychopathological-assessment-of-risk-of-restraint-in-acute-psychiatric-patients
#2
Federico Dazzi, Lorenzo Tarsitani, Michele Di Nunzio, Valeria Trincia, Gabriella Scifoni, Giuseppe Ducci
The study aims to identify independent predictors of physical restraint in acute psychiatric patients and to determine the predictive power of a risk assessment model centered on psychopathological dimensions. We included 1552 patients admitted to a psychiatric intensive care unit over a 5-year period. Patients were rated on the Brief Psychiatric Rating Scale (BPRS-E) at admission. Principal axis factoring (PAF) with varimax rotation was performed on BPRS-E items to identify psychopathological factors. Multiple logistic regression analysis was performed...
March 18, 2017: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/28318521/teaching-the-basics-of-echocardiography-in-the-undergraduate-students-as-mentors
#3
A Arias Felipe, J Doménech García, I Sánchez Los Arcos, D Luordo, F J García Sánchez, J Villanueva Martínez, A Forero de la Sotilla, V Villena Garrido, J Torres Macho, G García de Casasola Sánchez
OBJECTIVE: To analyse the ability of medical students to incorporate the practical teaching of basic echocardiography planes using a peer mentoring design. METHODOLOGY: Thirty-six medical students previously trained in obtaining echocardiography planes (mentors) taught the other 5th-year students (n=126). The teaching methodology included three stages: theory (online course), basic training (three 15h sessions of practical experience in ultrasound and at least 20 echocardiographic studies per mentor) and objective structured clinical assessment (OSCA), which scored the appropriateness of the basic ultrasound planes and the correct identification of 16 cardiac structures...
March 15, 2017: Revista Clínica Española
https://www.readbyqxmd.com/read/28318162/-inclination-of-crown-and-tooth-longitudinal-axis-in-cephalometric-analysis-of-normal-occlusions
#4
Liu Xu, Ren Jing, Yang Xianrui, Wang Li
OBJECTIVE: We measured and analyzed the angle between the longitudinal axis of incisor crown and tooth to provide a reference for orthodontists for selecting orthodontic methods and evaluating treatment results. METHODS: A total of 120 participants were included according to the criteria of Andrews' six keys, and cephalometric radiograph under the instructions of modified natural head position acquirement method was performed. The angles of maxillary incisor crown longitudinal axis, tooth longitudinal axis, occlusion plane (OP), and true vertical (TV) plane were measured, as well as mandibular incisors...
December 1, 2016: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28314520/interaction-between-postural-asymmetry-and-visual-feedback-effects-in-undisturbed-upright-stance-control-in-healthy-adults
#5
Patrice R Rougier, Samir Boudrahem
OBJECTIVES: The technique of additional visual feedback has been shown to significantly decrease the center of pressure (CP) displacements of a standing subject. Body-weight asymmetry is known to increase postural instability due to difficulties in coordinating the reaction forces exerted under each foot and is often a cardinal feature of various neurological and traumatic diseases. To examine the possible interactions between additional visual feedback and body-weight asymmetry effects, healthy adults were recruited in a protocol with and without additional visual feedback, with different levels of body-weight asymmetry...
March 14, 2017: Neurophysiologie Clinique, Clinical Neurophysiology
https://www.readbyqxmd.com/read/28302418/lncrna-atb-microrna-200a-%C3%AE-catenin-regulatory-axis-involved-in-the-progression-of-hcv-related-hepatic-fibrosis
#6
Na Fu, Su-Xian Zhao, Ling-Bo Kong, Jing-Hua Du, Wei-Guang Ren, Fang Han, Qing-Shan Zhang, Wen-Cong Li, Cui Po, Rong-Qi Wang, Yu-Guo Zhang, Yue-Min Nan
OBJECTIVE(S): Long noncoding RNAs (lncRNAs)-activated by transforming growth factor beta (lncRNA-ATB) is known to be involved in the invasion of hepatocellular carcinoma by regulating target gene miR-200a. However, the role and molecular mechanisms of lncRNA-ATB/miR-200a in HCV-related liver fibrosis remains unclear. In this study, we examined the expression of lncRNA-ATB/miR-200a, and their target gene β-Catenin in liver tissues of HCV patients and hepatic stellate cells (HSCs) to elucidate the possible role of lncRNA-ATB/miR-200a axis in HSC activation and development of liver fibrosis...
March 13, 2017: Gene
https://www.readbyqxmd.com/read/28299385/no-impact-of-under-correction-and-joint-line-obliquity-on-clinical-outcomes-of-total-knee-arthroplasty-for-the-varus-knee
#7
Richard D Rames, Michael Mathison, Zachary Meyer, Robert L Barrack, Denis Nam
PURPOSE: It has been hypothesized that under-correction of a preoperative varus deformity may be more natural and improve outcomes after total knee arthroplasty (TKA). This study's purpose was to assess the impact of hip-knee-ankle (HKA) alignment and joint line obliquity on TKA outcomes for the varus knee. METHODS: All patients with a preoperative varus deformity received both preoperative and postoperative standing, full-length radiographs from which two independent observers performed radiographic measurements including the HKA axis and mechanical medial proximal tibial angle (mMPTA)...
March 15, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28292490/preference-weighting-of-health-state-values-what-difference-does-it-make-and-why
#8
Admassu N Lamu, Thor Gamst-Klaussen, Jan Abel Olsen
BACKGROUND: Most patient-reported outcome measures apply a simple summary score to assess health-related quality of life, whereby equal weight is normally assigned to each item. In the generic preference-based instruments, utility weighting is essential whereby health state values are estimated through preference elicitation and complex algorithms. OBJECTIVES: To examine the extent to which preference-weighted value sets differ from unweighted values in the five-level EuroQol five-dimensional questionnaire and the 15D instrument, on the basis of a comprehensive data set from six member countries of the Organisation for Economic Co-operation and Development, each with a representative healthy sample and seven disease groups (N = 7933)...
March 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28288173/microarray-profiling-of-circular-rnas-in-human-papillary-thyroid-carcinoma
#9
Nianchun Peng, Lixin Shi, Qiao Zhang, Ying Hu, Nanpeng Wang, Hui Ye
BACKGROUND: Non-coding circular RNAs (circRNAs) have displayed dysregulated expression in several human cancers. Here, we profiled the circRNA expression of papillary thyroid carcinoma (PTC) tumors to improve our understanding of PTC pathogenesis. METHODS: Microarray profiling was performed on 18 thyroid samples, consisting of six PTC tumors, six matching contralateral normal samples, and six benign thyroid lesions. After low-intensity filtering, hierarchical clustering revealed the circRNA expression patterns...
2017: PloS One
https://www.readbyqxmd.com/read/28277622/abortifacient-metapristone-ru486-derivative-interrupts-cxcl12-cxcr4-axis-for-ovarian-metastatic-chemoprevention
#10
Ning Zheng, Jiahang Chen, Tao Li, Weiqun Liu, Jian Liu, Hongning Chen, Jichuang Wang, Lee Jia
Recent global epidemiological studies revealed the lower ovarian cancer death from long-term use of oral contraceptives. However, the underlying mechanism of action is not clear. Here, we use the abortifacient metapristone (RU486 derivative) to test the hypothesis that the contraceptives might interrupt CXCL12/CXCR4 chemokine axis to inhibit ovarian cancer metastasis. Metapristone at concentrations (<IC50) remarkably reduces CXCL12-induced CXCR4 expression on ovarian SKOV-3 and IGROV-1 cell lines, and down-regulates the CXCR4-related mRNAs and intracellular proteins...
March 9, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28274212/analysis-of-the-three-dimensional-anatomical-variance-of-the-distal-radius-using-3d-shape-models
#11
Sebastian F Baumbach, Jakob Binder, Alexander Synek, Fabian G Mück, Yan Chevalier, Ekkehard Euler, Georg Langs, Lukas Fischer
BACKGROUND: Various medical fields rely on detailed anatomical knowledge of the distal radius. Current studies are limited to two-dimensional analysis and biased by varying measurement locations. The aims were to 1) generate 3D shape models of the distal radius and investigate variations in the 3D shape, 2) generate and assess morphometrics in standardized cut planes, and 3) test the model's classification accuracy. METHODS: The local radiographic database was screened for CT-scans of intact radii...
March 9, 2017: BMC Medical Imaging
https://www.readbyqxmd.com/read/28273494/cortisol-as-a-predictor-of-psychological-therapy-response-in-anxiety-disorders-systematic-review-and-meta-analysis
#12
REVIEW
Susanne Fischer, Anthony J Cleare
BACKGROUND: Although psychotherapy generally is effective in anxiety disorders, many patients are treatment-resistant. At the same time, some patients with anxiety disorders show alterations in the hypothalamic-pituitary-adrenal (HPA) axis, one of the major stress-responsive systems. Since raised levels of the end product of the HPA axis, cortisol, adversely affect cognition, we hypothesised that more pronounced alterations in cortisol levels would be associated with a less favourable response to psychotherapy...
February 24, 2017: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/28268769/six-axis-orthodontic-force-and-moment-sensing-system-for-dentist-technique-training
#13
Yoshiyuki Midorikawa, Hiroshi Takemura, Hiroshi Mizoguchi, Kohei Soga, Masao Kamimura, Kazuhiro Suga, Wei-Jen Lai, Zuisei Kanno, Motohiro Uo
The purpose of this study is to develop a sensing system device that measures three-axis orthodontic forces and three-axis orthodontic moments for dentist training. The developed sensing system is composed of six-axis force sensors, action sticks, sliders, and tooth models. The developed system also simulates various types of tooth row shape patterns in orthodontic operations, and measures a 14 × 6 axis orthodontic force and moment from tooth models simultaneously. The average force and moment error per loaded axis were 2...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268727/miniaturized-force-torque-sensor-for-in-vivo-measurements-of-tissue-characteristics
#14
M Hessinger, T Pilic, R Werthschutzky, P P Pott
This paper presents the development of a surgical instrument to measure interaction forces/torques with organic tissue during operation. The focus is on the design progress of the sensor element, consisting of a spoke wheel deformation element with a diameter of 12 mm and eight inhomogeneous doped piezoresistive silicon strain gauges on an integrated full-bridge assembly with an edge length of 500 μm. The silicon chips are contacted to flex-circuits via flip chip and bonded on the substrate with a single component adhesive...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28267040/aortic-arch-mechanics-measured-with-two-dimensional-speckle-tracking-echocardiography
#15
Rogério Teixeira, Ricardo Monteiro, Rui Baptista, Telmo Pereira, Miguel A Ribeiro, Alexandra Gonçalves, Nuno Cardim, Lino Gonçalves
PURPOSE: To study the feasibility of vascular mechanics at the aortic arch with two-dimensional speckle tracking echocardiography, as well as to define normal values and to compare results between hypertensive patients and healthy patients. METHODS: We included 107 patients (61 healthy patients and 46 hypertensive patients) who underwent a complete echocardiographic exam, including a short-axis view of the aortic arch. The speckle tracking methodology was used to calculate aortic arch mechanics offline (EchoPAC; GE Healthcare)...
March 6, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28265884/d%C3%A3-bridement-and-reconstrucion-improve-postoperative-sagittal-alignment-in-kyphotic-cervical-spinal-tuberculosis
#16
Zhimin Pan, Jiaquan Luo, Limin Yu, Yiwei Chen, Junlong Zhong, Zhiyun Li, Zhaoxun Zeng, Pingguo Duan, Yoon Ha, Kai Cao
BACKGROUND: Cervical spinal tuberculosis is relatively common in some developing countries. It erodes vertebrae and discs, which sometimes results in cervical kyphosis and myelopathy. However, to our knowledge, no studies have evaluated improvements to patient-reported outcomes among patients who undergo surgical cervical sagittal realignment after kyphotic cervical spinal tuberculosis has been treated by débridement and reconstruction. QUESTIONS/PURPOSES: (1) Can a spine with kyphotic cervical spinal tuberculosis be returned to normal alignment and fused successfully? (2) Will patient-reported outcomes be improved with this intervention? (3) Are patient-reported outcomes correlated with realignment? METHODS: Forty-six patients with kyphotic cervical spinal tuberculosis were evaluated in this retrospective study...
March 6, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28264636/mothers-parenting-stress-is-associated-with-salivary-cortisol-profiles-in-children-with-attention-deficit-hyperactivity-disorder
#17
Terpsichori Korpa, Panagiota Pervanidou, Eleni Angeli, Filia Apostolakou, Katerina Papanikolaou, Ioannis Papassotiriou, George P Chrousos, Gerasimos Kolaitis
The aim of this study was to explore the relation between mothers' parenting stress and the functioning of the hypothalamic-pituitary-adrenal axis (HPAA), as expressed by daily salivary cortisol concentrations, in their children diagnosed with Attention Deficit Hyperactivity Disorder (ADHD). Seventy-five children aged 6-11 years diagnosed with ADHD predominant Hyperactive-Impulsive/Combined (ADHD-HI/C, N = 49) and Inattentive symptoms (ADHD-I, N = 26) and 45 healthy peers and their mothers participated in the study...
March 6, 2017: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/28262985/smith-s-fracture-generally-occurs-after-falling-on-the-palm-of-the-hand
#18
Yusuke Matsuura, Tomoyuki Rokkaku, Kazuki Kuniyoshi, Kazuhisa Takahashi, Takane Suzuki, Aya Tanaka, Tomoyo Akasaka, Naoya Hirosawa, Maki Iwase, Atsuro Yamazaki, Sumihisa Orita, Seiji Ohtori
Orthopedic trauma surgeons often encounter Smith's fracture in patients who report that they have fallen on the palms of their hands. The aim of this study was to clarify the pathogenesis of Smith's fracture in basic clinical aspects. First, a survey was conducted for investigating the mechanism of injury and arm position at the time of injury among patients with Smith's fractures who consulted at our outpatient clinic. Second, we created three-dimensional finite element models (FEMs) to predict the influence of arm position on the type of injury resulting from a fall...
March 6, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28259264/mri-screening-in-operative-scheuermann-kyphosis-is-it-necessary
#19
Baron S Lonner, Courtney S Toombs, Michael Mechlin, Gina Ciavarra, Suken A Shah, Amer F Samdani, Paul Sponseller, Harry L Shufflebarger, Randal R Betz, Burt Yaszay, Peter O Newton
STUDY DESIGN: Patients with preoperative spine magnetic resonance imaging (MRI) studies from a prospective multicenter study of operative adolescent Scheuermann kyphosis (SK). OBJECTIVES: To investigate the usefulness of MRI screening in operative planning for SK surgeries. SUMMARY OF BACKGROUND DATA: Neural axis abnormalities in operative SK have not been previously studied with MRI screening, despite its use. METHODS: One orthopedic surgeon and two radiologists evaluated all images retrospectively...
March 2017: Spine Deformity
https://www.readbyqxmd.com/read/28255734/robot-assisted-laparoscopic-transperitoneal-infrarenal-lymphadenectomy-in-patients-with-locally-advanced-cervical-cancer-by-single-docking-do-we-need-a-backup-procedure
#20
Fatih Gucer, Selim Misirlioglu, Nuri Ceydeli, Cagatay Taskiran
To present our initial experience on the feasibility of robotic transperitoneal para-aortic lymphadenectomy up to left renal vein via single docking approach by high port insertion technique followed by left shoulder docking as a rescue backup procedure in surgically obstructed patients undergoing surgical staging because of locally advanced cervical cancer (LACC). Prospective observational preliminary study. Canadian Task Force classification II-3. Tertiary-care academic affiliated private hospital. Ten patients with LACC who underwent robotic transperitoneal infrarenal para-aortic lymphadenectomy between January 2012 and December 2014...
March 2, 2017: Journal of Robotic Surgery
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