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https://www.readbyqxmd.com/read/29456757/the-natural-history-of-spinal-deformity-in-patients-with-coffin-lowry-syndrome
#1
M Welborn, S Farrell, P Knott, E Mayekar, S Mardjetko
Purpose: Little is known about the natural history of spinal deformities in Coffin-Lowry syndrome (CLS). Our goal was to evaluate the spinal deformity progression and clinical impact. Methods: In this institutional review board-approved study, we performed a multinational retrospective review of six male CLS patients, aged 13 to 22 years at final follow-up, for a mean of 7.25 years (3 to 13). Results: All showed delayed skeletal maturity. Three had calcifications of their lower cervical ligamentum flavum, all experienced neural axis abnormalities, including lower extremity weakness, numbness and tingling and in one, quadriparesis...
February 1, 2018: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/29455124/combination-effects-of-airborne-particulate-matter-exposure-and-high-fat-diet-on-hepatic-fibrosis-through-regulating-the-ros-endoplasmic-reticulum-stress-tgf%C3%AE-smads-axis-in-mice
#2
Shibin Ding, Lanlan Yu, Baijie An, Guofu Zhang, Pengxin Yu, Zhe Wang
BACKGROUND: Hepatic fibrosis, characterized by an excessive accumulation of extracellular matrix, is associated with toxic substance exposure, chronic infections, mechanical injury, airborne fine particulate matter (PM2.5 ) exposure and metabolic disease. This study aimed to investigate the effect and mechanism of long-term, real-world airborne particulate matter (PM) exposure on hepatic fibrosis and further explored whether combination treatment of PM exposure and high-fat diet (HFD) aggravate the adverse effects in mice...
February 14, 2018: Chemosphere
https://www.readbyqxmd.com/read/29449047/validation-and-update-of-a-lymph-node-metastasis-prediction-model-for-breast-cancer
#3
Si-Qi Qiu, Merel Aarnink, Marissa C van Maaren, Monique D Dorrius, Arkajyoti Bhattacharya, Jeroen Veltman, Caroline A H Klazen, Jan H Korte, Susanne H Estourgie, Pieter Ott, Wendy Kelder, Huan-Cheng Zeng, Hendrik Koffijberg, Guo-Jun Zhang, Gooitzen M van Dam, Sabine Siesling
PURPOSE: This study aimed to validate and update a model for predicting the risk of axillary lymph node (ALN) metastasis for assisting clinical decision-making. METHODS: We included breast cancer patients diagnosed at six Dutch hospitals between 2011 and 2015 to validate the original model which includes six variables: clinical tumor size, tumor grade, estrogen receptor status, lymph node longest axis, cortical thickness and hilum status as detected by ultrasonography...
January 17, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29431743/sorafenib-promotes-graft-versus-leukemia-activity-in-mice-and-humans-through-il-15-production-in-flt3-itd-mutant-leukemia-cells
#4
Nimitha R Mathew, Francis Baumgartner, Lukas Braun, David O'Sullivan, Simone Thomas, Miguel Waterhouse, Tony A Müller, Kathrin Hanke, Sanaz Taromi, Petya Apostolova, Anna L Illert, Wolfgang Melchinger, Sandra Duquesne, Annette Schmitt-Graeff, Lena Osswald, Kai-Li Yan, Arnim Weber, Sonia Tugues, Sabine Spath, Dietmar Pfeifer, Marie Follo, Rainer Claus, Michael Lübbert, Christoph Rummelt, Hartmut Bertz, Ralph Wäsch, Johanna Haag, Andrea Schmidts, Michael Schultheiss, Dominik Bettinger, Robert Thimme, Evelyn Ullrich, Yakup Tanriver, Giang Lam Vuong, Renate Arnold, Philipp Hemmati, Dominik Wolf, Markus Ditschkowski, Cordula Jilg, Konrad Wilhelm, Christian Leiber, Sabine Gerull, Jörg Halter, Claudia Lengerke, Thomas Pabst, Thomas Schroeder, Guido Kobbe, Wolf Rösler, Soroush Doostkam, Stephan Meckel, Kathleen Stabla, Stephan K Metzelder, Sebastian Halbach, Tilman Brummer, Zehan Hu, Joern Dengjel, Björn Hackanson, Christoph Schmid, Udo Holtick, Christof Scheid, Alexandros Spyridonidis, Friedrich Stölzel, Rainer Ordemann, Lutz P Müller, Flore Sicre-de-Fontbrune, Gabriele Ihorst, Jürgen Kuball, Jan E Ehlert, Daniel Feger, Eva-Maria Wagner, Jean-Yves Cahn, Jacqueline Schnell, Florian Kuchenbauer, Donald Bunjes, Ronjon Chakraverty, Simon Richardson, Saar Gill, Nicolaus Kröger, Francis Ayuk, Luca Vago, Fabio Ciceri, Antonia M Müller, Takeshi Kondo, Takanori Teshima, Susan Klaeger, Bernhard Kuster, Dennis Dong Hwan Kim, Daniel Weisdorf, Walter van der Velden, Daniela Dörfel, Wolfgang Bethge, Inken Hilgendorf, Andreas Hochhaus, Geoffroy Andrieux, Melanie Börries, Hauke Busch, John Magenau, Pavan Reddy, Myriam Labopin, Joseph H Antin, Andrea S Henden, Geoffrey R Hill, Glen A Kennedy, Merav Bar, Anita Sarma, Donal McLornan, Ghulam Mufti, Betul Oran, Katayoun Rezvani, Omid Sha, Robert S Negrin, Arnon Nagler, Marco Prinz, Andreas Burchert, Andreas Neubauer, Dietrich Beelen, Andreas Mackensen, Nikolas von Bubnoff, Wolfgang Herr, Burkhard Becher, Gerard Socié, Michael A Caligiuri, Eliana Ruggiero, Chiara Bonini, Georg Häcker, Justus Duyster, Jürgen Finke, Erika Pearce, Bruce R Blazar, Robert Zeiser
Individuals with acute myeloid leukemia (AML) harboring an internal tandem duplication (ITD) in the gene encoding Fms-related tyrosine kinase 3 (FLT3) who relapse after allogeneic hematopoietic cell transplantation (allo-HCT) have a 1-year survival rate below 20%. We observed that sorafenib, a multitargeted tyrosine kinase inhibitor, increased IL-15 production by FLT3-ITD+ leukemia cells. This synergized with the allogeneic CD8+ T cell response, leading to long-term survival in six mouse models of FLT3-ITD+ AML...
February 12, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29431106/beneficial-effect-of-mas-receptor-deficiency-on-vascular-cognitive-impairment-in-the-presence-of-angiotensin-ii-type-2-receptor
#5
Akinori Higaki, Masaki Mogi, Jun Iwanami, Li-Juan Min, Hui-Yu Bai, Bao-Shuai Shan, Masayoshi Kukida, Toshifumi Yamauchi, Kana Tsukuda, Harumi Kan-No, Shuntaro Ikeda, Jitsuo Higaki, Masatsugu Horiuchi
BACKGROUND: The classical renin-angiotensin system is known as the angiotensin (Ang)-converting enzyme/Ang II/Ang type 1 receptor axis, which induces various organ damage including cognitive decline. The angiotensin-converting enzyme 2/Ang-(1-7)/Mas axis is known to exert antagonistic actions against the classical renin-angiotensin system axis in the cardiovascular system. However, its roles in the brain remain unclear. We examined possible roles of the angiotensin-converting enzyme 2/Ang-(1-7)/Mas axis in cognitive function, employing vascular cognitive impairment model mice...
February 3, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29430101/incidence-of-dentinal-defects-during-root-canal-preparation-with-hand-files-using-different-irrigants-an-in-vitro-study
#6
Ruchi Singla, Swaty Jhamb, Amandeep Kaur, Ruchi Vashisht
Introduction: The purpose of this in vitro study was to compare the incidence of dentinal defects during root canal preparation with hand files using different irrigants. Materials and Methods: A total of 120 extracted mandibular incisors were randomly divided into onecontrol group and five experimental groups (n = 20) depending on the irrigant used. Biomechanical preparation was not done in control group. Teeth in experimental groups were prepared with hand K-files to a master apical file #35 with 1-mm increments step-back up to #50...
November 2017: Journal of Conservative Dentistry: JCD
https://www.readbyqxmd.com/read/29423064/melatonin-attenuated-brain-death-tissue-extract-induced-cardiac-damage-by-suppressing-damp-signaling
#7
Pei-Hsun Sung, Fan-Yen Lee, Ling-Chun Lin, Kuan-Hung Chen, Hung-Sheng Lin, Pei-Lin Shao, Yi-Chen Li, Yi-Ling Chen, Kun-Chen Lin, Chun-Man Yuen, Hsueh-Wen Chang, Mel S Lee, Hon-Kan Yip
We tested the hypothesis that melatonin prevents brain death (BD) tissue extract (BDEX)-induced cardiac damage by suppressing inflammatory damage-associated molecular pattern (DAMP) signaling in rats. Six hours after BD induction, levels of a DAMP component (HMGB1) and inflammatory markers (TLR-2, TLR-4, MYD88, IκB, NF-κB, IL-1β, IFN-γ, TNF-α and IL-6) were higher in brain tissue from BD animals than controls. Levels of HMGB1 and inflammatory markers were higher in BDEX-treated H9C2 cardiac myoblasts than in cells treated with healthy brain tissue extract...
January 9, 2018: Oncotarget
https://www.readbyqxmd.com/read/29415469/circsmarca5-inhibits-migration-of-glioblastoma-multiforme-cells-by-regulating-a-molecular-axis-involving-splicing-factors-srsf1-srsf3-ptb
#8
Davide Barbagallo, Angela Caponnetto, Matilde Cirnigliaro, Duilia Brex, Cristina Barbagallo, Floriana D'Angeli, Antonio Morrone, Rosario Caltabiano, Giuseppe Maria Barbagallo, Marco Ragusa, Cinzia Di Pietro, Thomas Birkballe Hansen, Michele Purrello
Circular RNAs (circRNAs) have recently emerged as a new class of RNAs, highly enriched in the brain and very stable within cells, exosomes and body fluids. To analyze their involvement in glioblastoma multiforme (GBM) pathogenesis, we assayed the expression of twelve circRNAs, physiologically enriched in several regions of the brain, through real-time PCR in a cohort of fifty-six GBM patient biopsies and seven normal brain parenchymas. We focused on hsa_circ_0001445 (circSMARCA5): it was significantly downregulated in GBM biopsies as compared to normal brain tissues (p-value < 0...
February 6, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29413741/reciprocal-changes-in-sagittal-alignment-with-operative-treatment-of-adolescent-scheuermann-kyphosis-prospective-evaluation-of-96-patients
#9
Baron S Lonner, Stefan Parent, Suken A Shah, Paul Sponseller, Burt Yaszay, Amer F Samdani, Patrick J Cahill, Joshua M Pahys, Randal Betz, Yuan Ren, Harry L Shufflebarger, Peter O Newton
INTRODUCTION: Sagittal alignment abnormalities in Scheuermann kyphosis (SK) strongly correlate with quality of life measures. The changes in spinopelvic parameters after posterior spinal fusion have not been adequately studied. This study is to evaluate the reciprocal changes in spinopelvic parameters following surgical correction for SK. METHODS: Ninety-six operative SK patients (65% male; age 16 years) with minimum 2-year follow-up were identified in the prospective multicenter study...
March 2018: Spine Deformity
https://www.readbyqxmd.com/read/29403645/impact-of-prenatal-stress-on-mother-infant-dyadic-behavior-during-the-still-face-paradigm
#10
Isabell Ann-Cathrin Wolf, Maria Gilles, Verena Peus, Barbara Scharnholz, Julia Seibert, Christine Jennen-Steinmetz, Bertram Krumm, Marcella Rietschel, Michael Deuschle, Manfred Laucht
Background: Mother-infant interaction provides important training for the infant's ability to cope with stress and the development of resilience. Prenatal stress (PS) and its impact on the offspring's development have long been a focus of stress research, with studies highlighting both harmful and beneficial effects. The aim of the current study was to examine the possible influence of both psychological stress and hypothalamic-pituitary-adrenal (HPA) axis activity during pregnancy with mother-child dyadic behavior following stress exposure...
2018: Borderline Personality Disorder and Emotion Dysregulation
https://www.readbyqxmd.com/read/29403249/-soft-that-molds-the-hard-geometric-morphometry-of-lateral-atlantoaxial-joints-focusing-on-the-role-of-cartilage-in-changing-the-contour-of-bony-articular-surfaces
#11
Prashant Kumar Prasad, Pravin Salunke, Daisy Sahni, Parveen Kalra
Purpose: The existing literature on lateral atlantoaxial joints is predominantly on bony facets and is unable to explain various C1-2 motions observed. Geometric morphometry of facets would help us in understanding the role of cartilages in C1-2 biomechanics/kinematics. Objective: Anthropometric measurements (bone and cartilage) of the atlantoaxial joint and to assess the role of cartilages in joint biomechanics. Materials and Methods: The authors studied 10 cadaveric atlantoaxial lateral joints with the articular cartilage in situ and after removing it, using three-dimensional laser scanner...
October 2017: Journal of Craniovertebral Junction and Spine
https://www.readbyqxmd.com/read/29401069/validity-and-reproducibility-of-various-measurement-methods-for-craniocervical-sagittal-balance
#12
Koji Tamai, Akinobu Suzuki, Shinji Takahashi, Masatoshi Hoshino, Hiromitsu Toyoda, Kazunori Hayashi, Shoichiro Ohyama, Yuichi Kishimura, Ema Onode, Masayuki Umano, Hidetomi Terai, Hiroaki Nakamura
STUDY DESIGN: A cross-sectional study. OBJECTIVE: To identify the best indicator for reproducible representation of craniocervical sagittal balance (CCSB). SUMMARY OF BACKGROUND DATA: Spinal sagittal balance is considered one of the most critical factors affecting the health-related quality of life. Although standard indicators of spinopelvic balance have been established, these do not include the craniocervical balance and there is no standard parameter for evaluating the CCSB...
February 2, 2018: Clinical Spine Surgery
https://www.readbyqxmd.com/read/29396474/nicotine-associated-breast-cancer-in-smokers-is-mediated-through-high-level-of-ezh2-expression-which-can-be-reversed-by-methyltransferase-inhibitor-dznepa
#13
Kanchan Kumari, Biswajit Das, Amit Adhya, Sanjib Chaudhary, Shantibhusan Senapati, Sandip K Mishra
Recent studies show substantial growth-promoting properties of nicotine (NIC) in cancer, which is a combined outcome of genetic and epigenetic alterations. However, the role of epigenetic modifiers in response to NIC in breast cancer is less studied. In the present study, for the first time we have shown NIC-induced enhanced EZH2 expression. Six pairs of smoking-associated breast cancer patient tissues were analyzed. Samples from smoking breast cancer patients showed distinguished enhanced EZH2 expression in comparison to non-smoking ones...
February 2, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29394433/biomechanics-of-lumbar-motion-segments-in-dynamic-compression
#14
Mike W J Arun, Prasannaah Hadagali, Klaus Driesslein, William Curry, Narayan Yoganandan, Frank A Pintar
Recent epidemiology studies have reported increase in lumbar spine injuries in frontal crashes. Whole human body finite element models (FEHBM) are frequently used to delineate mechanisms of such injuries. However, the accuracy of these models in mimicking the response of human spine relies on the characterization data of the spine model. The current study set out to generate characterization data that can be input to FEHBM lumbar spine, to obtain biofidelic responses from the models. Twenty-five lumbar functional spinal units were tested under compressive loading...
November 2017: Stapp Car Crash Journal
https://www.readbyqxmd.com/read/29394321/treatment-of-nasal-deviation-with-underlying-bony-asymmetry-secondary-to-augmentation-rhinoplasty-in-asian-patients
#15
Po-Ching Lee, Ray-Hon Chang, Yean-Lu Chang
Background: In Asian patients, nasal deviation secondary to augmentation rhinoplasty may result from underlying bony asymmetry that was not corrected intraoperatively. Diagnosis and treatment of this condition are complicated by the masking effect of dorsal implants. Objectives: The authors applied computed tomography (CT) to examine the causes of nasal deviation after augmentation rhinoplasty. CT results were utilized in preoperative planning for revisional surgery...
January 11, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29392420/cardioprotective-effect-of-ghrelin-against-myocardial-infarction-induced-left-ventricular-injury-via-inhibition-of-socs3-and-activation-of-jak2-stat3-signaling
#16
Refaat A Eid, Mahmoud A Alkhateeb, Samy Eleawa, Fahaid H Al-Hashem, Mubarak Al-Shraim, Attalla Farag El-Kott, Mohamed Samir Ahmed Zaki, Mohammad A Dallak, Hussain Aldera
The molecular mechanisms through which ghrelin exerts its cardioprotective effects during cardiac remodeling post-myocardial infarction (MI) are poorly understood. The aim of this study was to investigate whether the cardioprotection mechanisms are mediated by modulation of JAK/STAT signaling and what triggers this modulation. Rats were divided into six groups (n = 12/group): control, sham, sham + ghrelin (100 µg/kg, s.c., daily, starting 1 day post-MI), MI, MI+ ghrelin, and MI+ ghrelin+ AG490, a potent JAK2 inhibitor (5 mg/kg, i...
February 1, 2018: Basic Research in Cardiology
https://www.readbyqxmd.com/read/29392045/importance-of-sonoelastography-in-assessing-non-thyroid-neck-masses
#17
Mustafa Şahin, İdil Tatar, Aydın Kurt, Ömer Bayır, Güleser Saylam, Baki Hekimoğlu, Hakan Korkmaz
Objective: To evaluate the feasibility and value of sonoelastography in assessing non-thyroid neck masses. Methods: Non-thyroid neck masses requiring surgical interventions were evaluated using conventional B-mode ultrasonography (US) (size, short/long axis rate, shape, hilum, echogenity, calcification, necrosis, and peripheral edema) and sonoelastograpy (SE) with strain ratio (SR) and elasticity score (ES) before surgery. These parameters were compared with the histopathological examination...
March 2017: Turkish Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/29390799/non-adiabatic-quantum-reactive-scattering-in-hyperspherical-coordinates
#18
Brian K Kendrick
A new electronically non-adiabatic quantum reactive scattering methodology is presented based on a time-independent coupled channel formalism and the adiabatically adjusting principal axis hyperspherical coordinates of T Pack and Parker [J. Chem. Phys. 87, 3888 (1987)]. The methodology computes the full state-to-state scattering matrix for A + B2(v, j) ↔ AB(v', j') + B and A + AB(v, j) → A + AB(v', j') reactions that involve two coupled electronic states which exhibit a conical intersection. The methodology accurately treats all six degrees of freedom relative to the center-of-mass which includes non-zero total angular momentum J and identical particle exchange symmetry...
January 28, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29390295/management-of-a-neurotrophic-deep-corneal-ulcer-with-amniotic-membrane-transplantation-in-a-patient-with-functional-monocular-vision-a-case-report
#19
Tobias Röck, Karl Ulrich Bartz-Schmidt, Daniel Röck
RATIONALE: Amniotic membrane transplantation (AMT) has been performed therapeutically in humans for over 100 years. In recent 2 decades AMTs have been used increasingly and successfully to treat various types of ophthalmic indications. PATIENT CONCERNS: An 83-year-old man was referred to our eye hospital with a refractory neurotrophic deep corneal ulcer of the left eye. DIAGNOSES: The best-corrected visual acuity of the left eye was 0.5 (0...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29389313/using-behavior-over-time-graphs-to-spur-systems-thinking-among-public-health-practitioners
#20
Larissa Calancie, Seri Anderson, Jane Branscomb, Alexsandra A Apostolico, Kristen Hassmiller Lich
Public health practitioners can use Behavior Over Time (BOT) graphs to spur discussion and systems thinking around complex challenges. Multiple large systems, such as health care, the economy, and education, affect chronic disease rates in the United States. System thinking tools can build public health practitioners' capacity to understand these systems and collaborate within and across sectors to improve population health. BOT graphs show a variable, or variables (y axis) over time (x axis). Although analyzing trends is not new to public health, drawing BOT graphs, annotating the events and systemic forces that are likely to influence the depicted trends, and then discussing the graphs in a diverse group provides an opportunity for public health practitioners to hear each other's perspectives and creates a more holistic understanding of the key factors that contribute to a trend...
February 1, 2018: Preventing Chronic Disease
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