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https://www.readbyqxmd.com/read/29456969/mutation-of-agr-is-associated-with-the-adaptation-of-staphylococcus-aureus-to-the-host-during-chronic-osteomyelitis
#1
Carlos M Suligoy, Santiago M Lattar, Mariángeles Noto Llana, Cintia D González, Lucía P Alvarez, D Ashley Robinson, Marisa I Gómez, Fernanda R Buzzola, Daniel O Sordelli
Selection pressures exerted on Staphylococcus aureus by host factors may lead to the emergence of mutants better adapted to the evolving conditions at the infection site. This study was aimed at identifying the changes that occur in S. aureus exposed to the host defense mechanisms during chronic osteomyelitis and evaluating whether these changes affect the virulence of the organism. Genome assessment of two S. aureus isolates collected 13 months apart (HU-85a and HU-85c) from a host with chronic osteomyelitis was made by whole genome sequencing...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29097917/post-mortem-leukocyte-scintigraphy-in-juvenile-pigs-with-experimentally-induced-osteomyelitis
#2
Pia Afzelius, Ole Lerberg Nielsen, Svend Borup Jensen, Aage Kristian Olsen Alstrup
We have previously demonstrated that (111)In-labeled autologous leukocyte scintigraphy is able to detect osteomyelitis in living juvenile pigs. In animal research studies, it may well be an advantage if the animals could be scanned after euthanasia. Applying traditional scanning of living animals to euthanized animals will render anaesthesia unnecessary and be ideal for obtaining good and reliable scans for the correct interpretation of imaging afterwards, since the animals do not move. The autologous leukocytes of the pigs were collected, marked with (111)In, and reinjected into the pigs and allowed for homing to the site of infections as usual while the pigs were alive...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/28855966/correlating-pre-operative-mri-measurements-of-metatarsal-osteomyelitis-with-surgical-clean-margins-reveals-the-need-for-a-one-centimeter-resection-margin
#3
Brent Bernstein, Melody Stouder, Eric Bronfenbrenner, Steven Chen, David Anderson
BACKGROUND: Due to the high incidence of forefoot ulcerations with associated osteomyelitis, there has been an increased demand for partial ray amputations. In order to ensure complete removal of infected metatarsal bone, a clean margin amount is chosen based on the surgeon's intraoperative visual subjective evaluation. The margin is resected and sent to pathology. Currently the literature shows positive proximal margin rates of 35-40%. The purpose of this study was to reduce the rate of positive proximal margins by effectively resecting all infected bone using pre-operative MRI measurements with an added resection margin...
2017: Journal of Foot and Ankle Research
https://www.readbyqxmd.com/read/28675976/post-osteomyelitic-acquired-radial-club-hand-deformity-in-children-treated-by-centralization-of-ulna
#4
Dinesh Kumar Meena
INTRODUCTION: Radial club hand deformity acquired post haematogenous osteomyelitis of radius bone is a very rare disease. Resulting in functional and cosmetic deficit of upper limb which is similar to congenital cases. For a long-time various surgeons attempted to reconstruct the deformity by bone grafting, plating, Ilizarov, monorail external fixator, callus distraction and so on. Keeping in mind that creating single bone forearm we proposed centralization of ulna on wrist to correct the deformity...
May 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28638013/-surgical-treatment-of-diabetic-neuroosteoarthropathy-dnoap-and-its-long-term-results
#5
V M Bensman, Yu P Savchenko, S E Gumenyuk, K G Triandafilov, P P Vasil'chenko, S N Pyatakov, V V Khoritonenko
AIM: To develop pathogenetically justified surgical treatment of diabetic neuroosteoarthropathy (DNOAP). MATERIAL AND METHODS: 52 patients were operated and long-term results were studied in 36 of them. 2 groups were assessed depending on completeness of surgical treatment including changed synovial structures removal. Tarso-metatarsal arthrodesis was created after synovectomy in median foot to restore longitudinal arch. Cruro-calcaneal neoarthrosis was performed after elimination of posterior focus of DNOAP...
2017: Khirurgiia
https://www.readbyqxmd.com/read/28508595/silver-nanoparticle-deposited-implants-to-treat-osteomyelitis
#6
Samit Kumar Nandi, Anish Shivaram, Susmita Bose, Amit Bandyopadhyay
In this study, electrolytically deposited strongly adherent silver nanoparticles on stainless-steel (SS) implants were used for in situ osteomyelitis treatment. Samples were heat treated to enhance adhesion of silver on 316 L SS. Ex vivo studies were performed to measure silver-release profiles from the 316 L SS screws inserted in equine cadaver bones. No change in the release profiles of silver ions were observed in vitro between the implanted screws and the control. In vivo studies were performed using osteomyelitic rabbit model with 3 mm diameter silver-deposited 316 L SS pins at two different doses of silver: high and low...
May 15, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28091979/blood-perfusion-in-osteomyelitis-studied-with-15-o-water-pet-in-a-juvenile-porcine-model
#7
Lars Jødal, Ole L Nielsen, Pia Afzelius, Aage K O Alstrup, Søren B Hansen
BACKGROUND: Osteomyelitis is a serious disease which can be difficult to treat despite properly instituted antibiotic therapy. This appears to be related at least partly to degraded vascularisation in the osteomyelitic (OM) lesions. Studies of perfusion in OM bones are, however, few and not quantitative. Quantitative assessment of perfusion could aid in the selection of therapy. A non-invasive, quantitative way to study perfusion is dynamic [(15)O]water positron emission tomography (PET)...
December 2017: EJNMMI Research
https://www.readbyqxmd.com/read/27989705/histochemical-observation-of-bony-reversal-lines-in-bisphosphonate-related-osteonecrosis-of-the-jaw
#8
Soung Min Kim, Mi Young Eo, Yeon Sook Kim, Suk Keun Lee
OBJECTIVE: To contrast the pattern of bony reversal linesin bisphosphonate osteonecrosis of the jaw with infected osteomyelitis derived acute osteonecrosis of the jaw. STUDY DESIGN: This study investigated the histochemical characteristics of reversal lines in 50 cases of BP-related osteonecrosis of the jaw (BRONJ) compared with non-BP-involved bones in 20 cases of chronic osteomyelitis of the jaws. Necrotic bones were stained by using the toluidine blue, Safranin O, Giemsa, van Gieson, and Masson's trichrome staining methods...
February 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/27695555/calvarial-tubercular-osteomyelitic-abscess-in-an-elderly
#9
Bhavanam Hanuma Srinivas, Megha Shantveer Uppin, Sateesh Killi, Malladi Venkata Surya Subbalaxmi, Madhusudan Patil, Alugolu Rajesh
Tuberculous osteomyelitis of skull is very rare, even in areas where tuberculosis is endemic. We herein describe an elderly woman who was apparently immunocompetent and presented with left frontal scalp swelling and right cervical lymphadenopathy. CT scan showed irregular bony destruction of the frontal bone. MRI revealed a large extradural, multiseptate, solid-cystic lesion with peripheral enhancement. FNAC from the lesion showed granulomas with caseation suggestive of tuberculosis. The lesion was debrided and she was started on anti-tubercular therapy...
October 2016: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/27622146/antibiotic-loaded-phosphatidylcholine-inhibits-staphylococcal-bone-infection
#10
Jessica Amber Jennings, Karen E Beenken, Robert A Skinner, Daniel G Meeker, Mark S Smeltzer, Warren O Haggard, Karen S Troxel
AIM: To test antibiotic-loaded coating for efficacy in reducing bacterial biofilm and development of osteomyelitis in an orthopaedic model of implant infection. METHODS: Phosphatidylcholine coatings loaded with 25% vancomycin were applied to washed and sterilized titanium wires 20 mm in length. A 10 mm segment was removed from rabbit radius (total = 9; 5 coated, 4 uncoated), and the segment was injected with 1 × 10(6) colony forming units (CFUs) of Staphylococcus aureus (UAMS-1 strain)...
August 18, 2016: World Journal of Orthopedics
https://www.readbyqxmd.com/read/27598583/effects-of-transpositional-muscle-flaps-transfected-with-vascular-endothelial-growth-factor-gene-in-the-treatment-of-experimental-osteomyelitis
#11
Mahir Aliyev, Andaç Aykan, Muhitdin Eski, Nuri Arslan, Bülent Kurt, Mustafa Şengezer
BACKGROUND: Based on the angiogenetic and stimulating effects of bone healing and formation of vascular endothelial growth factor (VEGF), the present study was designed to assess the efficacy of VEGF gene application in the management of experimentally induced osteomyelitis. METHODS: Thirty-two male Sprague Dawley rats were divided into 4 groups, and osteomyelitis was induced in the left tibial bones. Group 1 (n=8) was designated as a control group, and, after the induction of osteomyelitis, no treatment was applied for a period of 4 weeks...
May 2016: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/27491284/squamous-cell-carcinoma-in-chronic-osteomyelitis-a-case-report-and-review-of-the-literature
#12
REVIEW
Gaetano Caruso, Emanuele Gerace, Vincenzo Lorusso, Rosario Cultrera, Loredana Moretti, Leo Massari
BACKGROUND: Chronic osteomyelitis is a challenging problem, and malignant transformation is a rare occurrence. We report a case of a patient with squamous cell carcinoma arising from an osteomyelitic hotbed and discuss through a literature review the etiopathogenesis, diagnosis, and treatment of this lesion. CASE PRESENTATION: A 69-year-old Italian man had sustained an exposed tibial fracture 40 years ago during a road accident, for which he had undergone various surgical osteosynthesis treatments with multiple antibiotic therapies...
August 4, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27448992/optimising-the-quality-and-outcomes-of-treatments-for-diabetic-foot-infections
#13
REVIEW
O Robineau, S Nguyen, E Senneville
INTRODUCTION: Infection is the commonest foot complication that arises in people with diabetes and may lead to amputation and even death. The emergence of multidrug resistant bacteria, especially in Gram negative rods, may have a negative impact on the chances of cure in these patients. AREAS COVERED: We searched the Medline and Pubmed databases for studies using the keywords 'diabetic foot infection' and 'diabetic foot osteomyelits' from 1980 to 2016. Expert commentary: Much has been done in the field of diabetic foot infection regarding pathophysiology, diagnosis and treatment...
September 2016: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/27424376/methicillin-resistant-staphyloccocus-aureus-intracranial-epidural-abscess-with-osteomyelitis-during-pregnancy-a-case-report
#14
Vaya W Tanamai, Brandon-Luke L Seagle, Guoyang Luo
BACKGROUND: The incidence of community-acquired methicillin-resistant Staphylococcus aureus (MRSA) infection is increasing, and 0.5-4% of pregnant women are colonized. CASE: A 30-year-old pregnant woman at term presented with intractable headache 1 week after incision and drainage of a MRSA-positive axillary abscess. Imaging demonstrated a right-sided epidural abscess with midline shift and myositis of the overlying temporalis muscle. She underwent cesarean delivery followed by craniectomy of osteomyelitic bone and evacuation of the epidural abscess...
May 2016: Journal of Reproductive Medicine
https://www.readbyqxmd.com/read/27071119/nlrp3-inflammasome-plays-a-redundant-role-with-caspase-8-to-promote-il-1%C3%AE-mediated-osteomyelitis
#15
Prajwal Gurung, Amanda Burton, Thirumala-Devi Kanneganti
Missense mutation in the proline-serine-threonine phosphatase-interacting protein 2 (Pstpip2) gene results in the development of spontaneous chronic bone disease characterized by bone deformity and inflammation that is reminiscent of patients with chronic multifocal osteomyelitis (cmo). Interestingly, this disease is specifically mediated by IL-1β but not IL-1α. The precise molecular pathways that promote pathogenic IL-1β production inPstpip2(cmo)mice remain unidentified. Furthermore, how IL-1β provokes inflammatory bone disease inPstpip2(cmo)mice is not known...
April 19, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/26961279/extension-and-grading-of-osteomyelitis-are-not-related-to-limb-salvage-in-charcot-neuropathic-osteoarthropathy-a-cohort-prospective-study
#16
COMPARATIVE STUDY
Luca Dalla Paola, Anna Carone, Marco Baglioni, Giulio Boscarino, Lucian Vasilache
AIMS: Charcot neuropathic osteoarthropathy (CN) represents a complication for diabetic patients which involves a progressive alteration of the osteoarticular apparatus with high risk of amputation. The aim of the study was to assess whether the localization of CN and the extent or grading of the osteomyelitis have an influence on the rate of limb salvage and the time to recovery. METHODS: We treated a diabetic population affected by CN complicated by ulceration and widespread osteomyelitic involvement...
May 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/26929564/long-term-follow-up-of-bimaxillary-osteomyelitis-associated-with-autosomal-dominant-osteopetrosis-a-case-report
#17
A Kulyapina, J Verdaguer Martin, C Navarro Cuellar, C Navarro Vila
Osteopetrosis (OP) is a rare metabolic bone disease characterized by a generalized increase in skeletal mass. The disease is characterized by increased susceptibility to develop osteomyelitis of the jaws. We report a case of clinical and radiological progression of bimaxillary osteomyelitis in a patient with autosomal dominant OP. The patient presented non simultaneous osteomyelitis in both upper and lower jaws with time interval of 10 years. The osteomyelitis of maxilla resulted in oroantral fistula formation and required surgical closure with Bichat fat pad flap...
March 2016: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/26872128/surgical-debridement-is-superior-to-sole-antibiotic-therapy-in-a-novel-murine-posttraumatic-osteomyelitis-model
#18
Johannes Maximilian Wagner, Hannah Zöllner, Christoph Wallner, Britta Ismer, Jessica Schira, Stephanie Abraham, Kamran Harati, Marcus Lehnhardt, Björn Behr
INTRODUCTION: Bone infections after trauma, i.e. posttraumatic osteomyelitis, pose one of the biggest problems of orthopedic surgery. Even after sufficient clinical therapy including vast debridement of infected bone and antibiotic treatment, regeneration of postinfectious bone seems to be restricted. One explanation includes the large sized defects resulting from sufficient debridement. Furthermore, it remains unclear if inflammatory processes after bone infection do affect bone regeneration...
2016: PloS One
https://www.readbyqxmd.com/read/26818330/time-interval-reduction-for-delayed-implant-based-cranioplasty-reconstruction-in-the-setting-of-previous-bone-flap-osteomyelitis
#19
Joseph Lopez, Shuting Susan Zhong, Eric W Sankey, Edward W Swanson, Harlyn Susarla, Ignacio Jusue-Torres, Judy Huang, Henry Brem, Paul G Auwaerter, Chad R Gordon
BACKGROUND: Reinfections following implant-based cranioplasty, in the setting of previous bone flap osteomyelitis, are common and associated with significant morbidity. The timing of reconstruction following initial osteomyelitic bone flap removal remains controversial; most advocate for prolonged time intervals of approximately 6 to 12 months. Thus, the authors investigated their delayed cranioplasty outcomes following both early (between 90 and 179 days) and late (≥ 180 days) time intervals with custom craniofacial implants to determine whether timing affected outcomes and rates of reinfection...
February 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/26644727/tuberculous-osteomyelitis-affecting-periodontium-a-rare-case-report
#20
Gaurav Bakutra, Balaji Manohar, Lalit Mathur
Tuberculous lesions affecting periodontium are rare and seen as secondary infections localized to the soft tissues. With the advent of effective drug therapy, tuberculous lesions of the oral cavity have become rare. Involvement of the periodontium has seldomly been reported in the recent literature. We report a case of tuberculous osteomyelitis of mandible affecting periodontium leading to gingival recession and bone exposure in the mandibular premolar region in a 42-year-old female patient. The diagnosis was based on patient's medical and dental history, bacterial culture, clinical and radiographic examination, blood investigation, immunologic tests, histopathologic examination of the tissue specimen...
September 2015: Journal of Indian Society of Periodontology
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