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https://www.readbyqxmd.com/read/29792351/peroxiredoxin-6-inhibits-osteogenic-differentiation-and-bone-formation-through-human-dental-pulp-stem-cells-and-induces-delayed-bone-development
#1
Kyung-Ran Park, Hyung-Mun Yun, In Jun Yeo, Sehyung Cho, Jin Tae Hong, Yong Seok Jeong
AIMS: Peroxiredoxins (PRDXs) are thiol-specific antioxidant enzymes that regulate redox balance that are critical for maintaining the cellular potential for self-renewal and stemness. Stem cell-based regenerative medicine is a promising approach in tissue reconstruction. However, to obtain functional cells for use in clinical applications, stem cell technology still requires improvements. RESULTS: In the present study, we found that PRDX6 levels were decreased during osteogenic differentiation in human dental pulp stem cells (hDPSCs)...
May 24, 2018: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29791703/biological-intercalary-reconstruction-with-bone-grafts-after-joint-sparing-resection-of-the-lower-limb-is-this-an-effective-and-durable-solution-for-joint-preservation
#2
Francesco Muratori, Francesca Totti, Antonio D'Arienzo, Maurizio Scorianz, Guido Scoccianti, Giovanni Beltrami, Francesco Rosario Campo, Carmine Citarelli, Rodolfo Capanna, Domenico Andrea Campanacci
Due to advances in neoadjuvant therapies and preoperative imaging modalities, joint-sparing resections have become appealing in bone tumor surgery. However, the intercalary reconstruction of metadiaphyseal bone defects of the femur and the tibia after juxta-articular tumor resection remains challenging. Both biological and prosthetic reconstructions have been used for joint-sparing resections, but little is known about the long-term outcome of these procedures. The authors reviewed a consecutive series of 64 patients treated with joint-sparing intercalary resection and reconstruction with bone grafts...
June 1, 2018: Surgical Technology International
https://www.readbyqxmd.com/read/29791702/all-inside-technique-for-acl-reconstruction-using-a-flipcutter%C3%A2-and-the-tightrope%C3%A2-system
#3
Nicos Papaloucas
There have been many innovations in the field of ACL-reconstruction over the years, including the FlipCutter® and TightRope® system (both from Arthrex Inc.). The FlipCutter® is a combined guide pin and reamer that allows minimally invasive socket-creation from the inside out, especially in difficult-to-reach areas. The TightRope® is a further development of the well-known Endobutton™ (Smith & Nephew plc) that consists of a four-point knotless locking system. Its main advantage is its adjustability, which makes it possible to fill the entire bone socket with the graft without any empty space...
June 1, 2018: Surgical Technology International
https://www.readbyqxmd.com/read/29788957/endothelial-progenitor-cells-improve-the-therapeutic-effect-of-mesenchymal-stem-cell-sheets-on-irradiated-bone-defect-repair-in-a-rat-model
#4
Huan Liu, Yang Jiao, Wei Zhou, Shizhu Bai, Zhihong Feng, Yan Dong, Qian Liu, Xiaoke Feng, Yimin Zhao
BACKGROUND: The reconstruction of bone defects is often impaired by radiotherapy since bone quality is compromised by radiation. This study aims to investigate the therapeutic efficacy of the composite cell sheets-bone marrow mesenchymal stem cell (BMSC) sheets cocultured with endothelial progenitor cells (EPCs)-in the healing of irradiated bone defects and the biological effects of EPCs on the osteogenic properties of BMSC sheets. METHODS: BMSCs and EPCs were isolated from rat bone marrow...
May 22, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29788923/the-segmentation-of-bones-in-pelvic-ct-images-based-on-extraction-of-key-frames
#5
Hui Yu, Haijun Wang, Yao Shi, Ke Xu, Xuyao Yu, Yuzhen Cao
BACKGROUND: Bone segmentation is important in computed tomography (CT) imaging of the pelvis, which assists physicians in the early diagnosis of pelvic injury, in planning operations, and in evaluating the effects of surgical treatment. This study developed a new algorithm for the accurate, fast, and efficient segmentation of the pelvis. METHODS: The proposed method consists of two main parts: the extraction of key frames and the segmentation of pelvic CT images...
May 22, 2018: BMC Medical Imaging
https://www.readbyqxmd.com/read/29788312/the-composite-spreader-flap
#6
Ozan Bitik, Haldun Onuralp Kamburoglu, Hakan Uzun
Background: The effect of a spreader flap on the keystone area and the upper bony vault depends on the structural strength and cephalic extent of upper lateral cartilages, both of which can be significantly variable among individuals. Objectives: The authors present a novel cephalically extended osseocartilaginous composite spreader flap technique that was designed to overcome the limitations of a conventional spreader flap on the keystone area upper bony vault, in patients with cephalically short and structurally weak upper lateral cartilages and thin nasal bones...
May 19, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29787853/false-aneurysm-of-the-popliteal-artery-complicated-by-a-deep-venous-thrombosis-revealing-an-exostosis-in-a-20-year-old-young-woman
#7
Tarik Bakkali, Mohamed Hormatallah, Ayoub Bounssir, Nabil Aghtoutane, Hamza Taous, Redouane Idrissi, Yasser Sefiani, Brahim Lekhel, Abbes Mesnaoui, Younes Bensaid
Exostoses or osteochondromas are benign osseous tumors that develop on the bone surface and can be sporadic or hereditary. Their evolution is generally benign but they may be complicated in some patients by conflicts with the surrounding nervous or vascular structures, in particular arteries. We report a case of false aneurysm of the popliteal artery secondary to an isolated exostosis of the left femur in a 20-year-old young woman. A delay in the diagnosis allowed the development of the false aneurysm which was at the origin of a major venous compression...
May 19, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29785677/analysis-of-the-frequency-of-visualization-of-morphological-variations-in-anatomical-bone-features-in-the-mandibular-interforaminal-region-through-cone-beam-computed-tomography
#8
Marilza do Carmo Oliveira, Tamara Kerber Tedesco, Thais Gimenez, Sergio Allegrini
PURPOSE: The purpose of this study was to analyze the frequency of visualization of anatomical bone features and their possible variations in the mandibular interforaminal region through cone-beam computed tomography (CBCT). METHODS: This is a cross-sectional study that evaluated CBCT scans of the mandible of 141 women and 61 men, obtained by imaging archives from two private clinics of dental radiology. The study analyzed the frequency of visualization of: lingual symphyseal foramen (LSF), additional mental foramen (AdMF), absence of mental foramen (AbMF), mandibular incisive canal (MIC), and anterior loop (AL)...
May 21, 2018: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/29784586/ultrasound-mediated-gene-delivery-enhances-tendon-allograft-integration-in-mini-pig-ligament-reconstruction
#9
Maxim Bez, Thomas J Kremen, Wafa Tawackoli, Pablo Avalos, Dmitriy Sheyn, Galina Shapiro, Joseph C Giaconi, Shiran Ben David, Jess G Snedeker, Zulma Gazit, Katherine W Ferrara, Dan Gazit, Gadi Pelled
Ligament injuries occur frequently, substantially hindering routine daily activities and sports participation in patients. Surgical reconstruction using autogenous or allogeneic tissues is the gold standard treatment for ligament injuries. Although surgeons routinely perform ligament reconstructions, the integrity of these reconstructions largely depends on adequate biological healing of the interface between the ligament graft and the bone. We hypothesized that localized ultrasound-mediated, microbubble-enhanced therapeutic gene delivery to endogenous stem cells would lead to significantly improved ligament graft integration...
April 26, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29783272/tendon-healing-in-bone-tunnel-after-human-anterior-cruciate-ligament-reconstruction-a-systematic-review-of-histological-results
#10
Hongbin Lu, Can Chen, Shanshan Xie, Yifu Tang, Jin Qu
Most studies concerning to tendon healing and incorporation into bone are mainly based on animal studies due to the invasive nature of the biopsy procedure. The evidence considering tendon graft healing to bone in humans is limited in several case series or case reports, and therefore, it is difficult to understand the healing process. A computerized search using relevant search terms was performed in the PubMed, EMBASE, Scopus, and Cochrane Library databases, as well as a manual search of reference lists. Searches were limited to studies that investigated tendon graft healing to bone by histologic examination after anterior cruciate ligament (ACL) reconstruction with hamstring...
May 21, 2018: Journal of Knee Surgery
https://www.readbyqxmd.com/read/29782609/low-cost-customized-cranioplasty-using-a-3d-digital-printing-model-a-case-report
#11
Abel De La Peña, Javier De La Peña-Brambila, Juan Pérez-De La Torre, Miguel Ochoa, Guillermo J Gallardo
Background: Cranial defects usually occur after trauma, neurosurgical procedures like decompressive craniotomy, tumour resections, infection and congenital defects. The purpose of cranial vault repair is to protect the underlying brain tissue, to reduce any localized pain and patient anxiety, and improve cranial aesthetics. Cranioplasty is a frequent neurosurgical procedure achieved with the aid of cranial prosthesis made from materials such as: titanium, autologous bone, ceramics and polymers...
2018: 3D printing in medicine
https://www.readbyqxmd.com/read/29782595/the-clinical-value-of-xspect-ct-bone-versus-spect-ct-a-prospective-comparison-of-200-scans
#12
Iain Duncan, Nicholas Ingold
Purpose: To prospectively evaluate the clinical utility of xSPECT/CT Bone, a new reconstruction algorithm for single photon emission tomography (SPECT), and compare it with standard SPECT/CT reconstruction. Methods: Sequential reporting of SPECT/CT followed by xSPECT/CT images in 200 sequential cases commencing August 2015. Differences between the initial SPECT/CT and the final report (after xSPECT/CT reconstruction) were documented and analysed. 12-18 months after the initial study follow-up, clinical data was sought from a subset of cases in which xSPECT/CT changed the primary diagnosis and imaging correlation undertaken in all patients who subsequently had MRI or CT scans of the same region...
2018: European journal of hybrid imaging
https://www.readbyqxmd.com/read/29781768/guided-bone-regeneration-and-implant-placement-in-association-with-a-coronally-positioned-palatal-sliding-flap-a-17-year-follow-up-case-report
#13
Carlo Maiorana, Pier Paolo Poli, Mario Beretta
The aim of the present case report was to show the 17-year hard and soft tissues stability of guided bone regeneration procedure associated with dental implants insertion. A 52-year-old male patient presented with a partial edentulism in the upper right maxilla. A graft consisting of deproteinized bovine bone mineral and autogenous bone stabilized by a non-resorbable expanded polytetrafluoroethylene membrane was used to reconstruct the missing bone applying the biological principles of guided bone regeneration...
May 21, 2018: Journal of Oral Implantology
https://www.readbyqxmd.com/read/29781765/individualized-titanium-mesh-combined-with-platelet-rich-fibrin-and-deproteinized-bovine-bone-a-new-approach-for-challenging-augmentation
#14
Jonas Lorenz, Sarah Al-Maawi, Robert Sader, Shahram Ghanaati
Autologous bone transfer is regarded as the gold standard for ridge augmentation before dental implantation, especially in severe bony defects caused by tumor resection or atrophy. In addition to the advantages of autologous bone, transplantation has several disadvantages, such as secondary operation, increased morbidity and pain. The present study reports, for the first time, a combination of a xenogeneic bone substitute (BO) with platelet-rich fibrin (PRF), which is a fully autologous blood concentrate derived from the patient's own peripheral blood by centrifugation...
May 21, 2018: Journal of Oral Implantology
https://www.readbyqxmd.com/read/29781248/the-role-of-3d-printing-in-treating-craniomaxillofacial-congenital-anomalies
#15
REVIEW
Christopher D Lopez, Lukasz Witek, Andrea Torroni, Roberto L Flores, David B Demissie, Simon Young, Bruce N Cronstein, Paulo G Coelho
Craniomaxillofacial congenital anomalies comprise approximately one third of all congenital birth defects and include deformities such as alveolar clefts, craniosynostosis, and microtia. Current surgical treatments commonly require the use of autogenous graft material which are difficult to shape, limited in supply, associated with donor site morbidity and cannot grow with a maturing skeleton. Our group has demonstrated that 3D printed bio-ceramic scaffolds can generate vascularized bone within large, critical-sized defects (defects too large to heal spontaneously) of the craniomaxillofacial skeleton...
May 20, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/29780843/adjustable-versus-fixed-loop-devices-for-femoral-fixation-in-acl-reconstruction-an-in-vitro-full-construct-biomechanical-study-of-surgical-technique-based-tibial-fixation-and-graft-preparation
#16
Patrick A Smith, Marina Piepenbrink, Shelby K Smith, Samuel Bachmaier, Asheesh Bedi, Coen A Wijdicks
Background: Femoral suspensory fixation for anterior cruciate ligament (ACL) reconstruction has evolved from fixed- to adjustable-loop devices. However, there are still controversies regarding undesired lengthening of adjustable-loop devices. Hypothesis: Adjustable-loop fixation will achieve similar elongation to that of fixed-loop devices, and intraoperative preconditioning will reduce initial elongation for adjustable-loop constructs. Study Design: Controlled laboratory study...
April 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29780202/common-occurrence-of-sharpey-s-fibres-in-amphibian-phalanges
#17
Krzysztof Kolenda, Anna Najbar, Beata Rozenblut-Kościsty, Ewa Serwa, Tomasz Skawiński
Sharpey's fibres are known mainly as providing anchorage between tooth and the periodontal ligament but they occur also in other types of bones. In the postcranial skeleton these fibres are usually present at the muscle or tendon attachment sites. They were reported in all major groups of extant vertebrates, as well as in putative lissamphibian ancestors-temnospondyls and lepospondyls. However, it was recently stated that their presence was very rarely described in extant amphibians. In limbs, they were reported predominantly from proximal bones...
2018: Zoomorphology
https://www.readbyqxmd.com/read/29780044/-effect-of-misregistration-between-spect-and-ct-images-on-attenuation-correction-for-quantitative-bone-spect-imaging
#18
Mika Sakoshi, Norikazu Matsutomo, Tomoaki Yamamoto, Eisuke Sato
PURPOSE: The aim of this study was to evaluate the effect of misregistration between single-photon emission computed tomography (SPECT) and computed tomography (CT) images on bone SPECT. METHODS: We acquired SPECT and CT images of a body phantom filled with bone-equivalent solution and 99m Tc for evaluation of bone SPECT. SPECT images were reconstructed using attenuation correction maps obtained by shifting the attenuation coefficients from non-shifted values (reference)...
2018: Nihon Hoshasen Gijutsu Gakkai Zasshi
https://www.readbyqxmd.com/read/29779271/-local-injection-of-exogenous-nerve-growth-factor-improves-early-bone-maturation-of-implants
#19
Yang Yao, Yu Du, Xia Gu, Meng-Kai Guang, Bo Huang, Ping Gong
OBJECTIVE: To investigate the effects of nerve growth factor (NGF) in the osteogenic action of implants and the maturation and reconstruction changes in bone tissues in the early stage of osseointegration. METHODS: The mouse implant model was established by placing titanium in the femoral head of the mouse and locally injecting NGF in the implant zone. On 1, 2 and 4 weeks after operation, stain samples were collected from animals using hematoxylin-eosin (HE) staining and Masson staining...
April 1, 2018: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/29778637/total-mandibulectomy-defect-in-the-setting-of-chronic-bisphosphonate-use
#20
Ameya A Jategaonkar, Arvind K Badhey, Fiyin Sokoya, Sameep Kadakia, Steven Mudrovich, Yadranko Ducic
Bisphosphonates are among several drugs known in modern medicine to have a potentially deleterious effect on the mandible with chronic use. While purportedly causing a necrotic reaction in the bone, the complete mechanism is not fully elucidated yet as cases are quite rare in the general public. Despite the esoteric nature of this entity, patients suffering from bisphosphonate induced necrosis have a complicated and prolonged course often involving varying degrees of mandibular debridement with severe cases requiring reconstruction...
May 16, 2018: American Journal of Otolaryngology
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