Read by QxMD icon Read

Erythroblastosis fetalis

M Villanueva, J M Fulbright, K A Horii
UNLABELLED: Phototherapy for hyperbilirubinemia has rare complications. We report a case of phototherapy induced eruption in a neonate with transient porphyrinemia. Our patient received phototherapy due to hyperbilirubinemia secondary to erythroblastosis fetalis (hemolytic disease of the newborn). He developed a cutaneous rash in the light-exposed areas of his skin. Erythrocyte and plasma porphyrins were elevated at the time. Phototherapy induced eruption with a transient porphyrinemia is rare...
2015: Journal of Neonatal-perinatal Medicine
T Sui, S Ying, A M Korsunsky, G Landini
Numerous diseases are known to cause microstructural alteration of dental tissues structure. One type in particular is associated with neonatal jaundice and circulation of bilirubin in blood at high concentration due to increased hemolysis in conditions such as erythroblastosis fetalis, septicemia, biliary atresia, and other causes of hyperbilirubinemia. In those conditions, the products of the catabolism of hemoglobin end up deposited in various tissues, including teeth, where they can present clinically as visibly stained brown/green teeth...
July 2015: Journal of Dental Research
Graham W Magor, Michael R Tallack, Kevin R Gillinder, Charles C Bell, Naomi McCallum, Bronwyn Williams, Andrew C Perkins
We describe a case of severe neonatal anemia with kernicterus caused by compound heterozygosity for null mutations in KLF1, each inherited from asymptomatic parents. One of the mutations is novel. This is the first described case of a KLF1-null human. The phenotype of severe nonspherocytic hemolytic anemia, jaundice, hepatosplenomegaly, and marked erythroblastosis is more severe than that present in congenital dyserythropoietic anemia type IV as a result of dominant mutations in the second zinc-finger of KLF1...
April 9, 2015: Blood
Anna Kucińska-Chahwan, Diana Massalska, Julia Bijok, Magdalena Rudzińska, Izabella Kopeć, Lech Rzymkiewicz, Grzegorz Jakiel, Tomasz Roszkowski
Maternal alloimmunization can lead to hemolytic anemia, hydrops fetalis and even fetal or neonatal death. Intrauterine treatment is possible and effective even though it is associated with some risk. We present a rare method of maternal blood intrauterine transfusions in the therapy of three difficult cases of erythroblastosis fetalis. The aim of this report was to present an alternative to volunteer donors. In severe cases, i.e. in the absence of matching blood types from the donor in the presence of multiple alloantibodies in the pregnant woman or if multiple transfusions are required, this can be the only therapeutic option...
September 2014: Ginekologia Polska
Hiroyasu Yasuda, Hitoshi Ohto, Kenneth E Nollet, Kinuyo Kawabata, Shunnichi Saito, Yoshihito Yagi, Yutaka Negishi, Atsushi Ishida
Hemolytic disease of the fetus and newborn (HDFN) attributed to M/N-incompatibility varies from asymptomatic to lethally hydropic. Case reports are rare, and the clinical significance of anti-M is not completely understood. A challenging case of HDFN due to anti-M prompted an investigation of the Japanese literature, in order to characterize the clinical spectrum of M/N-incompatibility pregnancies in Japan and report results to English-language readers. Japanese reports of HDFN attributed to M/N incompatibility were compiled...
January 2014: Transfusion Medicine Reviews
Arwa Z Al Riyami, Moza Al Salmani, Sabria Al Hashami, Sabah Al Mahrooqi, Sumaiya Al Hinai, Halima Al Balushi, Nihal Al Riyami, V Gowri, Tamima Al Dughaishi, Saif Al Hosni, Murtadha Al-Khabori, Khalil Al-Farsi, Mohammed Al Huneini, Salam Alkindi
BACKGROUND: The management of pregnant women with anti-Jsb is challenging due to the paucity of antigen-negative blood for fetal and neonatal transfusion. CASE REPORT: A 29-year-old woman with anti-Jsb was referred for assessment of recurrent fetal losses. With the presence of the sister as a historically matched donor, she was planned for active surveillance for fetal anemia during pregnancy. STUDY DESIGN AND METHODS: The fetus remained well until 21 weeks of gestation when signs of fetal anemia and early hydrops fetalis were noted...
January 2014: Transfusion
I T M Lindenburg, I L van Kamp, E W van Zwet, J M Middeldorp, F J C M Klumper, D Oepkes
OBJECTIVES: To evaluate and compare perinatal outcome after intrauterine transfusions (IUT) performed before and after 20 weeks of gestation. To analyse contributing factors. DESIGN: Retrospective analysis. SETTING: The Dutch referral centre for fetal therapy. POPULATION: IUTs for fetal alloimmune anaemia. METHODS: Fetuses were divided into two groups: fetuses requiring the first IUT before 20 weeks of gestation (Group 1) and those in which the IUTs started after 20 weeks (Group 2)...
June 2013: BJOG: An International Journal of Obstetrics and Gynaecology
Kenneth J Moise, Pedro S Argoti
OBJECTIVE: To evaluate the application of new technologies to the management of the red cell alloimmunized pregnancy. DATA SOURCES: We searched three computerized databases for studies that described treatment or prevention of alloimmunization in pregnancy (MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials [1990 to July 2012]). The text words and MeSH included Rhesus alloimmunization, Rhesus isoimmunization, Rhesus prophylaxis, Rhesus disease, red cell alloimmunization, red cell isoimmunization, and intrauterine transfusion...
November 2012: Obstetrics and Gynecology
Tzu-Hung Lin, Jin-Chung Shih, Chia-Hui Lin, Shin-Yu Lin, Yi-Ning Su, Chien-Nan Lee
OBJECTIVE: To present intensive intrauterine treatment of recurrent early onset fetal erythroblastosis due to anti-M alloimmunization. CASE REPORT: A 33-year-old woman, gravid 3, para 1, had anti-M IgG antibody, which caused alloimmunization of her previous pregnancies. This time she visited our hospital for intensive intervention. No evidence of fetal hydrops was found during ultrasound examination at 12 weeks of gestation. Plasmapheresis was given from 17 weeks of gestation but fetal erythroblastosis still developed 1 week later...
June 2012: Taiwanese Journal of Obstetrics & Gynecology
Belma Saygili Karagol, Aysegul Zenciroglu, Nurullah Okumus, Nilgun Karadag, Arzu Dursun, Nilay Hakan
OBJECTIVE: To determine the clinical spectrum of hemolytic disease due to irregular blood subgroup incompatibility in hospitalized neonates. STUDY DESIGN: The medical records of the all hospitalized newborn patients diagnosed with indirect hyperbilirubinemia due to subgroup incompatibility in Kell, C, c, E, and e systems were included in the study. Data from 106 newborns with hemolytic jaundice due to irregular blood subgroups were retrospectively evaluated, and clinical and laboratory findings were compared between patients ...
June 2012: American Journal of Perinatology
David M Tasso, Karla K Dunning, Robert W McKenna, Stefan E Pambuccian
No abstract text is available yet for this article.
May 2013: Diagnostic Cytopathology
Katarina Pejić, Borisav Janković, Zeljko Miković, Zorica Rakonjac, Jelena Martić, Natasa Stajić
INTRODUCTION: Non-immune hydrops fetalis is a condition of excessive accumulation of extravascular fluid without identifiable circulating antibody to erythrocytes membrane antigens. In newborn infants it is characterized by skin oedema and pleural, pericardial or peritoneal effusion. In the era of routine Rh immunization for the prevention of foetal erythroblastosis, non-immune pathophysiologic mechanisms are presented in 76-87% of all hydropic newborns. Non-immune hydrops fetalis can be associated with numerous and various disorders...
September 2011: Medicinski Pregled
René Monico-Ramos, Mauro Ochoa-Flores, Ricardo Jorge Hernández-Herrera, Eduardo Flores-Pompa
INTRODUCTION: the leading cause of fetal anemia is Rh isoimmunization. The timely diagnosis by ultrasound and intravascular transfusion improves the prognosis. OBJECTIVE: to evaluate the increase in hemoglobin in the fetus and correlate the red cell transfusion volume with elevation of hemoglobin and perinatal outcome. PATIENTS AND METHODS: prospective, case series study. We included 17 patients with fetal anemia detected by measuring the peak systolic velocity of middle cerebral artery and determination of fetal hemoglobin before and after cordocentesis...
June 2011: Ginecología y Obstetricia de México
Luis Javier Ramírez-Robles, Guillermo Gómez-Partida, Guillermo Guevara-Rubio, Leonora Velázquez-Gómez
BACKGROUND: Diagnosis, care and prevention of hemolytic disease in fetuses and newborns is the most prominent historical example of a successful medical procedure aimed to abate perinatal morbidity and mortality caused by a disease which for centuries was described only unknown origin. OBJECTIVE: To review the perinatal outcome with intrauterine transfusion (IUT) in severe alloimmunization RhD over 21 years in a referral center of Mexico. The overall survival rate of fetuses and the relations with gestational age, and presence or absence of hydrops was analyzed...
September 2010: Ginecología y Obstetricia de México
Sana Abourazzak, Safae Hajjaj, Chekabab Hakima, Abdelhak Bouharrou, Moustapha Hida
Anti-D isoimmunisation remains the most common cause of erythroblastosis fetalis. Whereas most clinically significant blood group sensitisations noted during pregnancy are still secondary to anti-D incompatibility, sensitisation to antigens other than D in the CDE system is not uncommon and can cause severe disease. The widespread use of Rh-D immune globulin has led to a relative increase in the importance of non-Rh-D isoimmunisation as a cause of haemolytic disease of the newborn. We report the case of a baby with severe hyperbilirubinaemia and persistent anaemia due to anti-c isoimmunisation with a high-titre maternal c antibody...
2009: BMJ Case Reports
H C Miller
No abstract text is available yet for this article.
March 1939: Yale Journal of Biology and Medicine
P Bricca, E Guinchard, C Guitton Bliem
Feto-maternal red cell alloimmunization is defined by the presence in a pregnant woman of alloantibodies directed against blood group antigens present on the red blood cells of the fetus and inherited from the father. It arises from the immune response to a first contact to these same antigens during a prior transfusion, transplant or pregnancy. The placental transfer and the fixation of the antibodies on the fetal red cells antigenic targets lead to a haemolysis in the fetus and the newborn. The resulting haemolytic disease can show different clinical forms, from a mild anaemia with neonatal hyperbilirubinemia to a major fetal damage with stillbirth caused by hydrops fetalis...
April 2011: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
No abstract text is available yet for this article.
May 1946: Journal of Pediatrics
No abstract text is available yet for this article.
April 15, 1946: New York State Journal of Medicine
No abstract text is available yet for this article.
April 1946: Journal of Pediatrics
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"