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https://www.readbyqxmd.com/read/29785050/the-tumor-suppressor-dlc1-inhibits-cancer-progression-and-oncogenic-autophagy-in-hepatocellular-carcinoma
#1
Hui-Ta Wu, Cheng-Rong Xie, Jie Lv, He-Qiang Qi, Fei Wang, Sheng Zhang, Qin-Liang Fang, Fu-Qiang Wang, Yu-Yan Lu, Zhen-Yu Yin
Downregulation of deleted in liver cancer 1 (DLC1) is associated with poor prognosis of various cancers, but its functional mechanisms in hepatocellular carcinoma (HCC) remains unclear. In the present study, we investigated the roles of DLC1 in tumor progression and autophagy of HCC. We found that DLC1 was frequently downregulated in HCC tissues. Underexpression of DLC1 correlated with AFP level, vascular invasion, poor differentiation, and poor prognosis. In vitro assays revealed that DLC1 not only suppressed the proliferation, migration, and invasion of HCC cells, but also inhibited autophagy of HCC cells...
May 21, 2018: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/29783729/chlorogenic-acid-improves-the-regorafenib-effects-in-human-hepatocellular-carcinoma-cells
#2
Maria Grazia Refolo, Catia Lippolis, Nicola Carella, Aldo Cavallini, Caterina Messa, Rosalba D'Alessandro
Chlorogenic acid (CGA) is a polyphenol present in many human dietary foods. Several studies indicated a beneficial role of CGA in the prevention of cancer and an enhancement of chemotherapy when combined with CGA in the treatment of human hepatocarcinoma (HCC). Drug toxicity, resistance and subsequent disease progression represent a problem in HCC management, although treatment with the multikinase inhibitor Regorafenib improved overall survival. This study focused on the evaluation of the effects of combined treatment using both low Regorafenib concentrations and CGA as natural compound in HCC cells...
May 19, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29781870/pregnancy-and-the-apoptotic-pathway-in-experimental-melanoma
#3
Anamaria S Facina, Gil Facina, Ismael D C Guerreiro da Silva, Silvana A A Corrêa, Sandra M Alexandre, Ângela F Logullo, Jorge K Hosomi, Mary U Nakamura
Pregnancy-associated melanoma is defined as melanoma diagnosed during pregnancy or within 1 year of delivery. The association of pregnancy with melanoma is well known, but its underlying molecular mechanisms of association are poorly understood. The aim was to assess the expression of apoptosis-related genes in melanoma tumors during pregnancy in an attempt to elucidate the molecular mechanisms underlying apoptosis-driven activation of melanoma cells in this period. Mice were allocated across two experimental groups (nonpregnant and pregnant) and implanted with the melanoma cell line BF16-F10...
May 17, 2018: Melanoma Research
https://www.readbyqxmd.com/read/29771447/intermedin1-53-protects-cardiac-function-in-rats-with-septic-shock-via-inhibiting-oxidative-stress-and-cardiomyocyte-apoptosis
#4
Y-J Yu, A-H Su, H-B Yang, J-X Chen
OBJECTIVE: To investigate the protective effect of intermedin1-53 (IMD1-53) on cardiac function in rats with septic shock and its underlying mechanism. MATERIALS AND METHODS: Twenty-four male Sprague-Dawley (SD) rats were randomly assigned into three groups, namely the control group (NC group), septic shock group (ET group) and IMD1-53 treatment group (IMD group), with 8 rats in each group. Levels of hemodynamic indicators, blood glucose, lactate acid, CK-MB (creatine kinase-MB) and cTnI (cardiac troponin I) in rats were determined...
May 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29768138/knockdown-of-the-prolyl-isomerase-pin1-inhibits-hep-2-cells-growth-migration-and-invasion-by-targeting-%C3%AE-catenin-signaling-pathway
#5
Guoliang Fan, Lin Wang, Jia Xu, Ping Jiang, Wei Wang, Ying Huang, Minggang Lv, Shaoting Liu
Increasing evidence indicates that peptidylprolyl cis/trans isomerase, NIMA-interacting 1 (Pin1) plays a decisive role in a variety of cancers. Nevertheless, its function in laryngeal squamous cell carcinoma (LSCC) has not been elaborated. The aim of this study is to determine the role of Pin1 in LSCC. Here, we established stably transfected Hep-2 cells with low expression of Pin1. Intriguingly, ability of cell proliferation, migration and invasion was significantly inhibited in Pin1-silenced Hep-2 cells. Similarly, knockdown of Pin1 induced apoptosis of Hep-2 cells, as evidenced by increased expression of cleaved-caspase-3, cleaved-PARP, and bax, and decreased expression of bcl2...
May 16, 2018: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/29766980/ripasudil-attenuates-lipopolysaccharide-lps-mediated-apoptosis-and-inflammation-in-pulmonary-microvascular-endothelial-cells-via-rock2-enos-signaling
#6
Jianxin Yang, Feng Ruan, Zhongjun Zheng
BACKGROUND Microvascular endothelial inflammation and apoptosis are responsible for septic acute lung injury (ALI). Ripasudil is a novel Rho/Rho kinase (ROCK) inhibitor which shows therapeutic effects on several vascular diseases. The aim of this study was to investigate the protective effects and correlated molecular mechanisms of ripasudil on lipopolysaccharide- induced inflammation and apoptosis of pulmonary microvascular endothelial cells (PMVECs). MATERIAL AND METHODS Cultured PMVECs were exposed to lipopolysaccharide (LPS)...
May 16, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29762687/glycine-treatment-enhances-developmental-potential-of-porcine-oocytes-and-early-embryos-by-inhibiting-apoptosis
#7
Suo Li, Qing Guo, Yu-Meng Wang, Zi-Yue Li, Jin-Dan Kang, Xi-Jun Yin, Xin Zheng
Glycine, a component of glutathione (GSH), plays an important role in protection from reactive oxygen species (ROS) and inhibition of apoptosis. The aim of this study was to determine the effect of glycine on in vitro maturation (IVM) of porcine oocytes and their developmental competence after parthenogenetic activation (PA). We examined nuclear maturation, ROS levels, apoptosis, mitochondrial membrane potential (ΔΨm), and ATP concentration, as well as the expression of several genes related to oocyte maturation and development...
May 12, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29760419/plga-nanoparticles-co-delivering-mdr1-and-bcl2-sirna-for-overcoming-resistance-of-paclitaxel-and-cisplatin-in-recurrent-or-advanced-ovarian-cancer
#8
Chitra Risnayanti, Yeong-Su Jang, Jinju Lee, Hyung Jun Ahn
The inherent or acquired resistance to paclitaxel and cisplatin, which are commonly used chemotherapeutic agents for ovarian cancer treatment, remains an important issue in chemotherapy of multidrug resistant ovarian cancer. Currently, it is still challenging to deal with the recurrent or advanced stage ovarian cancer. When drug efflux and anti-apoptotic pathways are highly interdependent and also involved in developing the resistance of multidrug resistant ovarian cancer, simultaneous inhibition of both pathways represents the potential targets to enhance the efficacy of chemotherapy...
May 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29760085/mda-9-syntenin-regulates-protective-autophagy-in-anoikis-resistant-glioma-stem-cells
#9
Sarmistha Talukdar, Anjan K Pradhan, Praveen Bhoopathi, Xue-Ning Shen, Laura A August, Jolene J Windle, Devanand Sarkar, Frank B Furnari, Webster K Cavenee, Swadesh K Das, Luni Emdad, Paul B Fisher
Glioma stem cells (GSCs) comprise a small subpopulation of glioblastoma multiforme cells that contribute to therapy resistance, poor prognosis, and tumor recurrence. Protective autophagy promotes resistance of GSCs to anoikis, a form of programmed cell death occurring when anchorage-dependent cells detach from the extracellular matrix. In nonadherent conditions, GSCs display protective autophagy and anoikis-resistance, which correlates with expression of melanoma differentiation associated gene-9/Syntenin (MDA-9) (syndecan binding protein; SDCBP)...
May 14, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29752623/catalpol-promotes-the-survival-and-vegf-secretion-of-bone-marrow-derived-stem-cells-and-their-role-in-myocardial-repair-after-myocardial-infarction-in-rats
#10
Xing'ai Ju, Degang Xue, Tongyi Wang, Baiping Ge, Yu Zhang, Zhanquan Li
Bone mesenchymal stem cells (BMSCs) transplantation has been recognized as an effective method for the treatment of myocardial infarction (MI). However, its efficacy is always restricted by the low survival of transplanted BMSCs in the ischemic myocardium. The aim of this study was to investigate the effect of catalpol pre-treatment on the survival and vascular endothelial growth factor (VEGF) secretion of BMSCs under oxygen glucose deprivation (OGD) condition and their role in myocardial repair in a rat model of MI...
May 11, 2018: Cardiovascular Toxicology
https://www.readbyqxmd.com/read/29751043/tauroursodeoxycholic-acid-attenuates-gentamicin-induced-cochlear-hair-cell-death-in-vitro
#11
Zhanwei Jia, Qiang He, Chunguang Shan, Fengyi Li
Gentamycin is one of the most clinically used aminoglycoside antibiotics which induce intrinsic apoptosis of hair cells. Tauroursodeoxycholic acid (TUDCA) is known as safe cell-protective agent in disorders associated with apoptosis. We aimed to investigate the protective effects of TUDCA against gentamicin-induced ototoxicity. House Ear Institute-Organ of Corti 1(HEI-OC1) cells and explanted cochlear tissue were treated with gentamicin and TUDCA, followed by serial analyses including cell viability assay, hair cell staining, qPCR, ELISA and western blotting to determine the cell damage by the parameters relevant to cell apoptosis and endoplasmic reticulum stress...
May 8, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29750154/ginsenoside-rg3-suppresses-proliferation-and-induces-apoptosis-in-human-osteosarcoma
#12
Yi Li, Jinying Lu, Furong Bai, Yanan Xiao, Yiran Guo, Ziming Dong
Osteosarcoma is the most common primary malignancy of bone in children and the elderly. Recently, more and more researches have demonstrated that Ginsenoside Rg3 (Rg3) is involved in chemotherapy resistance in many cancer, making it a promising Chinese herbal monomer for oncotherapy. In this study, we investigated the efficacy of Rg3 in human osteosarcoma cell lines (MG-63, U-2OS, and SaOS-2). Cell proliferation was measured by CCK8 assay. The migration of cells was examined using the scratch assay method. Quantification of apoptosis was assessed further by flow cytometry...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29749471/gsk3%C3%AE-%C3%A2-mediated-ser156-phosphorylation-modulates-a-bh3%C3%A2-like-domain-in-bcl2l12-during-tmz%C3%A2-induced-apoptosis-and-autophagy-in-glioma-cells
#13
Cheng-Wei Chu, Ming-Chang Yang, Chia-Hua Chou, Wen-Sheng Huang, Bo-Xiu Hsiao, Yeng-Tseng Wang, Shean-Jaw Chiou, Joon-Khim Loh, Yi-Ren Hong
BH3 domains, classified initially as BCL2 homology domains, participate in both apoptosis and autophagy. Beclin‑1 contains a BH3 domain, which is required for binding to antiapoptotic BCL2 homologs and BCL2‑mediated inhibition of autophagy. BCL2‑like 12 (BCL2L12) also harbors a BH3‑like domain, which is 12 residues long and contains a LXXXAE/D motif. In a yeast two‑hybrid system performed in the present study, BCL2L12 shared similar binding partnerships to antiapoptotic BCL2 homologs, such as Beclin‑1...
May 11, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29742507/cyanidin-curtails-renal-cell-carcinoma-tumorigenesis
#14
Xiaobing Liu, Dangling Zhang, Yaxing Hao, Qian Liu, Yuqi Wu, Xin Liu, Jing Luo, Tao Zhou, Bishao Sun, Xing Luo, Jie Xu, Qingqing Wang, Zhenxing Yang, Longkun Li
BACKGROUND/AIMS: Cyanidin is an anthocyanin found in many foods. Although its variable antioxidant levels are well-documented, little is known about its effects on renal cell carcinoma (RCC) tumorigenesis. This study, therefore, investigated the effects of cyanidin on the proliferation, migration, and invasion of renal cell carcinoma lines and demonstrated, for the first time, significant inhibitory effects of cyanidin on RCC tumorigenesis. METHODS: RCC cells were treated with different doses of cyanidin and the effects were tested by Cell Counting Kit-8 reagent, clone formation assay, transwell assay, and flow cytometry...
May 5, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29734730/glioma-associated-oncogene-homolog-inhibitors-have-the-potential-of-suppressing-cancer-stem-cells-of-breast-cancer
#15
Kuo-Shyang Jeng, Chi-Juei Jeng, I-Shyan Sheen, Szu-Hua Wu, Ssu-Jung Lu, Chih-Hsuan Wang, Chiung-Fang Chang
Overexpression of Sonic Hedgehog signaling (Shh) pathway molecules is associated with invasiveness and recurrence in breast carcinoma. Therefore, inhibition of the Shh pathway downstream molecule Glioma-associated Oncogene Homolog (Gli) was investigated for its ability to reduce progression and invasiveness of patient-derived breast cancer cells and cell lines. Human primary breast cancer T2 cells with high expression of Shh signaling pathway molecules were compared with breast cancer line MDA-MB-231 cells...
May 5, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29731872/tropomyosin-1-promotes-cancer-cell-apoptosis-via-the-p53-mediated-mitochondrial-pathway-in-renal-cell-carcinoma
#16
Chao Tang, Jin Wang, Qi Wei, Yi-Peng Du, He-Ping Qiu, Chao Yang, Yu-Chuan Hou
Tropomyosin-1 (TPM1), a widely expressed actin-binding protein, is downregulated in many tumors and associated with cancer progression. A previous study from our group suggested that TPM1 could be involved in renal cell carcinoma (RCC) apoptosis, but the mechanisms and details remained unknown. The present study aimed to further examine the proapoptotic effects of TPM1 and investigate the underlying mechanisms in RCC cell lines. Results from cell viability, DAPI staining and apoptosis assays demonstrated that TPM1 upregulation inhibited cell proliferation and promoted cell apoptosis in both 786-O and ACHN RCC cell lines...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29731490/sulfasalazine-treatment-can-cause-a-positive-effect-on-lps-induced-endotoxic-rats
#17
Burak Dik, Gonca Sonmez, Hatice Eser Faki, Emre Bahcivan
The aim of this study, was to determine the effect of sulfasalazine for different periods of time reduces disseminated intravascular coagulation, inflammation and organ damages by inhibiting the nuclear factor kappa beta pathway. The study was performed with 30 Wistar albino rats and the groups were established as Control group, LPS group; endotoxemia was induced with LPS, SL5 group: sulfasalazine (300 mg/kg, single dose daily) was administered for 5 days before the LPS-induced endotoxemia, and LS group: sulfasalazine (300 mg/kg, single dose) was administered similtenously with LPS...
May 2, 2018: Experimental Animals
https://www.readbyqxmd.com/read/29724295/jtc-801-inhibits-the-proliferation-and-metastasis-of-ovarian-cancer-cell-skov3-through-inhibition-of-the-pi3k-akt-signaling-pathway
#18
Jun-Xia Li, Yan-Ping Bi, Jing Wang, Xue Yang, Yan-Fang Tian, Zhong-Fang Sun
Ovarian cancer (OC) is the commonest cause of gynaecological cancer-associated death because of the wide metastasis and frequent recidivation. JTC-801 is a new synthetic compound with the function of reversing pain and anxiety symptoms as a selective opioid receptor-like1 receptor (belonging to the G-protein-coupled receptor) antagonist. We investigated the role and possible mechanisms of JTC-801 in the cell growth and metastasis of OC. It was observed that JTC-801 inhibited the proliferation, invasion and migration of cancer in SKOV3 cells...
May 1, 2018: Die Pharmazie
https://www.readbyqxmd.com/read/29723988/dietary-%C3%AE-mangostin-provides-protective-effects-against-acetaminophen-induced-hepatotoxicity-in-mice-via-akt-mtor-mediated-inhibition-of-autophagy-and-apoptosis
#19
Xiao-Tong Yan, Yin-Shi Sun, Shen Ren, Li-Chun Zhao, Wen-Cong Liu, Chen Chen, Zi Wang, Wei Li
Acetaminophen overdose-induced hepatotoxicity is the most common cause of acute liver failure in many countries. Previously, alpha-mangostin (α-MG) has been confirmed to exert protective effects on a variety of liver injuries, but the protective effect on acetaminophen-induced acute liver injury (ALI) remains largely unknown. This work investigated the regulatory effect and underlying cellular mechanisms of α-MG action to attenuate acetaminophen-induced hepatotoxicity in mice. The increased serum aminotransferase levels and glutathione (GSH) content and reduced malondialdehyde (MDA) demonstrated the protective effect of α-MG against acetaminophen-induced hepatotoxicity...
May 1, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29712649/tolerance-to-paternal-genotoxic-damage-promotes-survival-during-embryo-development-in-zebrafish-danio-rerio
#20
Cristina Fernández-Díez, Silvia González-Rojo, Marta Lombó, M Paz Herráez
Spermatozoa carry DNA damage that must be repaired by the oocyte machinery upon fertilization. Different strategies could be adopted by different vertebrates to face the paternal genotoxic damage. Mammals have strong sperm selection mechanisms and activate a zygotic DNA damage response (DDR) (including cell cycle arrest, DNA repair and alternative apoptosis) in order to guarantee the genomic conformity of the reduced progeny. However, external fertilizers, with different reproductive strategies, seem to proceed distinctively...
April 30, 2018: Biology Open
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