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https://www.readbyqxmd.com/read/28652885/rapid-concentration-and-elution-of-malarial-antigen-histidine-rich-protein-ii-using-solid-phase-zn-ii-resin-in-a-simple-flow-through-pipette-tip-format
#1
Westley S Bauer, Kelly A Richardson, Nicholas M Adams, Keersten M Ricks, David J Gasperino, Simon J Ghionea, Mathew Rosen, Kevin P Nichols, Bernhard H Weigl, Frederick R Haselton, David W Wright
Rapid diagnostic tests (RDTs) designed to function at the point of care are becoming more prevalent in malaria diagnostics because of their low cost and simplicity. While many of these tests function effectively with high parasite density samples, their poor sensitivity can often lead to misdiagnosis when parasitemia falls below 100 parasites/μl. In this study, a flow-through pipette-based column was explored as a cost-effective means to capture and elute more Plasmodium falciparum histidine-rich protein II (HRPII) antigen, concentrating the biomarker available in large-volume lysed whole blood samples into volumes compatible with Plasmodium falciparum-specific RDTs...
May 2017: Biomicrofluidics
https://www.readbyqxmd.com/read/28615263/factors-associated-with-inflammation-in-preschool-children-and-women-of-reproductive-age-biomarkers-reflecting-inflammation-and-nutritional-determinants-of-anemia-brinda-project
#2
REVIEW
Rebecca D Merrill, Rachel M Burke, Christine A Northrop-Clewes, Pura Rayco-Solon, Rafael Flores-Ayala, Sorrel Ml Namaste, Mary K Serdula, Parminder S Suchdev
Background: In many settings, populations experience recurrent exposure to inflammatory agents that catalyze fluctuations in the concentrations of acute-phase proteins and certain micronutrient biomarkers such as C-reactive protein (CRP), α-1-acid glycoprotein (AGP), ferritin, and retinol. Few data are available on the prevalence and predictors of inflammation in diverse settings.Objective: We aimed to assess the relation between inflammation (CRP concentration >5 mg/L or AGP concentration >1 g/L) and covariates, such as demographics, reported illness, and anthropometric status, in preschool children (PSC) (age range: 6-59 mo) and women of reproductive age (WRA) (age range: 15-49 y)...
June 14, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28615262/predictors-of-anemia-in-women-of-reproductive-age-biomarkers-reflecting-inflammation-and-nutritional-determinants-of-anemia-brinda-project
#3
REVIEW
James P Wirth, Bradley A Woodruff, Reina Engle-Stone, Sorrel Ml Namaste, Victor J Temple, Nicolai Petry, Barbara Macdonald, Parminder S Suchdev, Fabian Rohner, Grant J Aaron
Background: Anemia in women of reproductive age (WRA) (age range: 15-49 y) remains a public health problem globally, and reducing anemia in women by 50% by 2025 is a goal of the World Health Assembly.Objective: We assessed the associations between anemia and multiple proximal risk factors (e.g., iron and vitamin A deficiencies, inflammation, malaria, and body mass index) and distal risk factors (e.g., education status, household sanitation and hygiene, and urban or rural residence) in nonpregnant WRA.Design: Cross-sectional, nationally representative data from 10 surveys (n = 27,018) from the Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project were analyzed individually and pooled by the infection burden and risk in the country...
June 14, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28615260/predictors-of-anemia-in-preschool-children-biomarkers-reflecting-inflammation-and-nutritional-determinants-of-anemia-brinda-project
#4
REVIEW
Reina Engle-Stone, Grant J Aaron, Jin Huang, James P Wirth, Sorrel Ml Namaste, Anne M Williams, Janet M Peerson, Fabian Rohner, Ravi Varadhan, O Yaw Addo, Victor Temple, Pura Rayco-Solon, Barbara Macdonald, Parminder S Suchdev
Background: A lack of information on the etiology of anemia has hampered the design and monitoring of anemia-control efforts.Objective: We aimed to evaluate predictors of anemia in preschool children (PSC) (age range: 6-59 mo) by country and infection-burden category.Design: Cross-sectional data from 16 surveys (n = 29,293) from the Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project were analyzed separately and pooled by category of infection burden. We assessed relations between anemia (hemoglobin concentration <110 g/L) and severe anemia (hemoglobin concentration <70 g/L) and individual-level (age, anthropometric measures, micronutrient deficiencies, malaria, and inflammation) and household-level predictors; we also examined the proportion of anemia with concomitant iron deficiency (defined as an inflammation-adjusted ferritin concentration <12 μg/L)...
June 14, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28615259/adjusting-ferritin-concentrations-for-inflammation-biomarkers-reflecting-inflammation-and-nutritional-determinants-of-anemia-brinda-project
#5
REVIEW
Sorrel Ml Namaste, Fabian Rohner, Jin Huang, Nivedita L Bhushan, Rafael Flores-Ayala, Roland Kupka, Zuguo Mei, Rahul Rawat, Anne M Williams, Daniel J Raiten, Christine A Northrop-Clewes, Parminder S Suchdev
Background: The accurate estimation of iron deficiency is important in planning and implementing interventions. Ferritin is recommended as the primary measure of iron status, but interpretability is challenging in settings with infection and inflammation.Objective: We assessed the relation between ferritin concentrations and inflammation and malaria in preschool children (PSC) (age range: 6-59 mo) and women of reproductive age (WRA) (age range: 15-49 y) and investigated adjustment algorithms to account for these effects...
June 14, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28615256/adjusting-soluble-transferrin-receptor-concentrations-for-inflammation-biomarkers-reflecting-inflammation-and-nutritional-determinants-of-anemia-brinda-project
#6
REVIEW
Fabian Rohner, Sorrel Ml Namaste, Leila M Larson, O Yaw Addo, Zuguo Mei, Parminder S Suchdev, Anne M Williams, Fayrouz A Sakr Ashour, Rahul Rawat, Daniel J Raiten, Christine A Northrop-Clewes
Background: Iron deficiency is thought to be one of the most prevalent micronutrient deficiencies globally, but an accurate assessment in populations who are frequently exposed to infections is impeded by the inflammatory response, which causes iron-biomarker alterations.Objectives: We assessed the relation between soluble transferrin receptor (sTfR) concentrations and inflammation and malaria in preschool children (PSC) (age range: 6-59 mo) and women of reproductive age (WRA) (age range: 15-49 y) and investigated adjustment algorithms to account for these effects...
June 14, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28615255/adjusting-total-body-iron-for-inflammation-biomarkers-reflecting-inflammation-and-nutritional-determinants-of-anemia-brinda-project
#7
REVIEW
Zuguo Mei, Sorrel Ml Namaste, Mary Serdula, Parminder S Suchdev, Fabian Rohner, Rafael Flores-Ayala, O Yaw Addo, Daniel J Raiten
Background: Total body iron (TBI) that is calculated from ferritin and soluble transferrin receptor (sTfR) allows for the evaluation of the full range of iron status from deficiency to excess. However, both ferritin and sTfR are affected by inflammation and malaria, which may require a statistical adjustment. TBI has been used to assess iron status in the United States, but its use worldwide and in settings with inflammation has been limited.Objective: We examine whether inflammation-adjusted ferritin and sTfR concentrations affect TBI values and the prevalence of low TBI (<0 mg/kg) in preschool children (PSC) (age range: 6-59 mo) and women of reproductive age (WRA) (age range: 15-49 y)...
June 14, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28615254/methodologic-approach-for-the-biomarkers-reflecting-inflammation-and-nutritional-determinants-of-anemia-brinda-project
#8
REVIEW
Sorrel Ml Namaste, Grant J Aaron, Ravi Varadhan, Janet M Peerson, Parminder S Suchdev
Background: The Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project is a multiagency and multicountry collaboration that was formed to improve micronutrient assessment and to better characterize anemia.Objectives: The aims of the project were to 1) identify factors associated with inflammation, 2) assess the relations between inflammation, malaria infection, and biomarkers of iron and vitamin A status and compare adjustment approaches, and 3) assess risk factors for anemia in preschool children (PSC) and women of reproductive age (WRA)...
June 14, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28615252/research-policy-and-programmatic-considerations-from-the-biomarkers-reflecting-inflammation-and-nutritional-determinants-of-anemia-brinda-project
#9
REVIEW
Rebecca J Stoltzfus, Rolf Klemm
The Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project sought to inform the interpretation of iron and vitamin A biomarkers (ferritin, serum transferrin receptor, and retinol binding protein) in settings of prevalent inflammation as well as the prevention of and control strategies to address anemia. Our purpose is to comment on the contributions of the BRINDA to advance global knowledge with regard to iron and vitamin A status assessment in women and preschool children and to analyze the findings in terms of their rigor and usefulness for global nutrition research and programs...
June 14, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28615251/adjusting-retinol-binding-protein-concentrations-for-inflammation-biomarkers-reflecting-inflammation-and-nutritional-determinants-of-anemia-brinda-project
#10
REVIEW
Leila M Larson, Sorrel Ml Namaste, Anne M Williams, Reina Engle-Stone, O Yaw Addo, Parminder S Suchdev, James P Wirth, Victor Temple, Mary Serdula, Christine A Northrop-Clewes
Background: The accurate estimation of the prevalence of vitamin A deficiency (VAD) is important in planning and implementing interventions. Retinol-binding protein (RBP) is often used in population surveys to measure vitamin A status, but its interpretation is challenging in settings where inflammation is common because RBP concentrations decrease during the acute-phase response.Objectives: We aimed to assess the relation between RBP concentrations and inflammation and malaria in preschool children (PSC) (age range: 6-59 mo) and women of reproductive age (WRA) (age range: 15-49 y) and to investigate adjustment algorithms to account for these effects...
June 14, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28604891/pre-concentration-by-liquid-intake-by-paper-p-clip-a-new-technique-for-large-volumes-and-digital-microfluidics
#11
Darius G Rackus, Richard P S de Campos, Calvin Chan, Maria M Karcz, Brendon Seale, Tanya Narahari, Christopher Dixon, M Dean Chamberlain, Aaron R Wheeler
Microfluidic platforms are an attractive option for incorporating complex fluid handling into low-cost and rapid diagnostic tests. A persistent challenge for microfluidics, however, is the mismatch in the "world-to-chip" interface - it is challenging to detect analytes present at low concentrations in systems that can only handle small volumes of sample. Here we describe a new technique termed pre-concentration by liquid intake by paper (P-CLIP) that addresses this mismatch, allowing digital microfluidics to interface with volumes on the order of hundreds of microliters...
June 12, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28602553/proteomic-profiling-of-the-brain-of-mice-with-experimental-cerebral-malaria
#12
Ehab Moussa, Honglei Huang, Malika Ahras, Amar Lall, Marie L Thezenas, Roman Fischer, Benedikt M Kessler, Arnab Pain, Oliver Billker, Climent Casals-Pascual
Cerebral malaria (CM) is a severe neurological complication of malaria infection in both adults and children. In pursuit of effective treatment of CM, clinical studies, postmortem analysis and animal models have been employed to understand the pathology and identify effective interventions. In this study, a shotgun proteomics analysis was conducted to profile the proteomic signature of the brain tissue of mice with experimental cerebral malaria (ECM) in order to further understand the underlying pathology. To identify CM-associated response, proteomic signatures of the brains of C57/Bl6N mice infected with P...
June 5, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28597541/restless-roosts-light-pollution-affects-behavior-sleep-and-physiology-in-a-free-living-songbird
#13
Jenny Q Ouyang, Maaike de Jong, Roy H A van Grunsven, Kevin D Matson, Mark F Haussmann, Peter Meerlo, Marcel E Visser, Kamiel Spoelstra
The natural nighttime environment is increasingly polluted by artificial light. Several studies have linked artificial light at night to negative impacts on human health. In free-living animals, light pollution is associated with changes in circadian, reproductive, and social behavior, but whether these animals also suffer from physiologic costs remains unknown. To fill this gap, we made use of a unique network of field sites which are either completely unlit (control), or are artificially illuminated with white, green, or red light...
June 9, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28587263/iron-for-africa-report-of-an-expert-workshop
#14
Martin N Mwangi, Kamija S Phiri, Abdelhak Abkari, Mory Gbané, Raphaelle Bourdet-Sicard, Véronique Azaïs Braesco, Michael B Zimmermann, Andrew M Prentice
Scientific experts from nine countries gathered to share their views and experience around iron interventions in Africa. Inappropriate eating habits, infections and parasitism are responsible for significant prevalence of iron deficiency, but reliable and country-comparable prevalence estimates are lacking: improvements in biomarkers and cut-offs values adapted to context of use are needed. Benefits of iron interventions on growth and development are indisputable and outweigh risks, which exist in populations with a high infectious burden...
June 5, 2017: Nutrients
https://www.readbyqxmd.com/read/28569315/enhancing-the-sensing-specificity-of-a-mos2-nanosheet-based-fret-aptasensor-using-a-surface-blocking-strategy
#15
Alisha Geldert, Kenry, Xiao Zhang, Hua Zhang, Chwee Teck Lim
Aptamer-based biosensing, which uses short, single-stranded nucleic acid segments to bind to a target, can be advantageous over antibody-based diagnostics due to the ease of synthesis and high stability of aptamers. However, the development of most aptamer-based sensors (aptasensors) is still in its initial stages and many factors affecting their performance have not been studied in great detail. Here, we enhance the sensing specificity of a fluorescence resonance energy transfer (FRET)-based MoS2 nanosheet aptasensor in detecting the malarial biomarker Plasmodium lactate dehydrogenase (pLDH)...
June 1, 2017: Analyst
https://www.readbyqxmd.com/read/28558710/a-metabolomic-analytical-approach-permits-identification-of-urinary-biomarkers-for-plasmodium-falciparum-infection-a-case-control-study
#16
Salah Abdelrazig, Catharine A Ortori, Gail Davey, Wakgari Deressa, Dhaba Mulleta, David A Barrett, Alemayehu Amberbir, Andrew W Fogarty
BACKGROUND: Currently available diagnostic techniques of Plasmodium falciparum infection are not optimal for non-invasive, population-based screening for malaria. It was hypothesized that a mass spectrometry-based metabolomics approach could identify urinary biomarkers of falciparum malaria. METHODS: The study used a case-control design, with cases consisting of 21 adults in central Ethiopia with a diagnosis of P. falciparum infection confirmed with microscopy, and 25 controls of adults with negative blood smears for malaria matched on age and sex...
May 30, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28552792/plasmodium-glyceraldehyde-3-phosphate-dehydrogenase-a-potential-malaria-diagnostic-target
#17
Robert G E Krause, Ramona Hurdayal, David Choveaux, Jude M Przyborski, Theresa H T Coetzer, J P Dean Goldring
Malaria rapid diagnostic tests (RDTs) are immunochromatographic tests detecting Plasmodial histidine-rich protein 2 (HRP2), lactate dehydrogenase (LDH) and aldolase. HRP2 is only expressed by Plasmodium falciparum parasites and the protein is not expressed in several geographic isolates. LDH-based tests lack sensitivity compared to HRP2 tests. This study explored the potential of the Plasmodial glycolytic enzyme, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), as a new malaria diagnostic biomarker. The P...
May 26, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28522856/diagnosing-congenital-malaria-in-a-high-transmission-setting-clinical-relevance-and-usefulness-of-p-falciparum-hrp2-based-testing
#18
Hamtandi Magloire Natama, Delwendé Florence Ouedraogo, Hermann Sorgho, Eduard Rovira-Vallbona, Elisa Serra-Casas, M Athanase Somé, Maminata Coulibaly-Traoré, Petra F Mens, Luc Kestens, Halidou Tinto, Anna Rosanas-Urgell
Congenital malaria diagnosis is challenging due to frequently observed low parasite density infections, while their clinical relevance during early infancy is not well characterized. In Nanoro health district (Burkina Faso), we determined the prevalence of congenital malaria by real-time quantitative PCR and we assessed the performance of rapid diagnosis test (RDT) and light microscopy (LM) to detect Plasmodium falciparum infections in cord-blood samples. In addition, we examined the usefulness of P. falciparum Histidine Rich Protein2 (PfHRP2) as surrogate biomarker of infection and explored association between congenital malaria and clinical outcomes...
May 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28516178/a-multi-walled-carbon-nanotube-zinc-oxide-nanofiber-based-flexible-chemiresistive-biosensor-for-malaria-biomarker-detection
#19
Brince Paul K, Asisa Kumar Panigrahi, Vikrant Singh, Shiv Govind Singh
We report the fabrication of a flexible, lightweight and disposable multi walled carbon nanotube (MWCNT)-zinc oxide (ZnO) nanofiber based chemiresistive biosensor for label free detection of the malaria biomarker, histidine rich protein II (HRP2). The sensing platform is formed by depositing nanofibers in between the source and drain electrodes patterned on a thin, flexible polyethylene terephthalate (PET) substrate. MWCNT-ZnO nanofibers are synthesized via the electrospinning technique followed by a calcination process...
May 18, 2017: Analyst
https://www.readbyqxmd.com/read/28465297/comprehensive-transcriptome-and-mutational-profiling-of-endemic-burkitt-lymphoma-reveals-ebv-type-specific-differences
#20
Yasin Kaymaz, Cliff I Oduor, Hongbo Yu, Juliana A Otieno, John Michael Ong'echa, Ann M Moormann, Jeffrey A Bailey
Endemic Burkitt lymphoma (eBL) is the most common pediatric cancer in malaria-endemic equatorial Africa and nearly always contains Epstein-Barr virus (EBV), unlike sporadic Burkitt lymphoma (sBL) that occurs with a lower incidence in developed countries. Given these differences and the variable clinical presentation and outcomes, we sought to further understand pathogenesis by investigating transcriptomes using RNA sequencing (RNAseq) from multiple primary eBL tumors compared with sBL tumors. Within eBL tumors, minimal expression differences were found based on: anatomical presentation site, in-hospital survival rates, and EBV genome type, suggesting that eBL tumors are homogeneous without marked subtypes...
May 2017: Molecular Cancer Research: MCR
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