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https://www.readbyqxmd.com/read/29902183/identification-and-validation-of-a-novel-panel-of-plasmodium-knowlesi-biomarkers-of-serological-exposure
#1
Lou S Herman, Kimberly Fornace, Jody Phelan, Matthew J Grigg, Nicholas M Anstey, Timothy William, Robert W Moon, Michael J Blackman, Chris J Drakeley, Kevin K A Tetteh
BACKGROUND: Plasmodium knowlesi is the most common cause of malaria in Malaysian Borneo, with reporting limited to clinical cases presenting to health facilities and scarce data on the true extent of transmission. Serological estimations of transmission have been used with other malaria species to garner information about epidemiological patterns. However, there are a distinct lack of suitable serosurveillance tools for this neglected disease. METHODOLOGY/PRINCIPAL FINDINGS: Using in silico tools, we designed and expressed four novel P...
June 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29892471/heart-failure-in-sub-saharan-africa
#2
REVIEW
Joseph Gallagher, Kenneth McDonald, Mark Ledwidge, Chris J Watson
Heart failure is a growing problem in sub-Saharan Africa. This arises as the prevalence of risk factors for cardiovascular disease rises, life expectancy increases and causes of heart failure more common in Africa, such as rheumatic heart disease and endomyocardial fibrosis, continue to be a significant issue. Lack of access to diagnostics is an issue with the expense and technical expertise required for echocardiography limiting access. Biomarker strategies may play a role here. Access to essential medicines is also limited and requires a renewed focus by the international community to ensure that appropriate medications are readily available, similar to that which has been implemented for HIV and malaria...
May 2018: Cardiac Failure Review
https://www.readbyqxmd.com/read/29869601/-anopheles-salivary-biomarker-as-a-proxy-for-estimating-plasmodium-falciparum-malaria-exposure-on-the-thailand-myanmar-border
#3
Phubeth Ya-Umphan, Dominique Cerqueira, Gilles Cottrell, Daniel M Parker, Freya J I Fowkes, Francois Nosten, Vincent Corbel
Timely identification and treatment of malaria transmission "hot spots" is essential to achieve malaria elimination. Here we investigate the relevance of using an Anopheles salivary biomarker to estimate Plasmodium falciparum malaria exposure risk along the Thailand-Myanmar border to guide malaria control. Between May 2013 and December 2014, > 9,000 blood samples collected in a cluster randomized control trial were screened with serological assays to measure the Ab responses to Anopheles salivary antigen (gSG6-P1) and P...
June 4, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29852003/causes-of-acute-undifferentiated-fever-and-the-utility-of-biomarkers-in-chiangrai-northern-thailand
#4
Tri Wangrangsimakul, Thomas Althaus, Mavuto Mukaka, Pacharee Kantipong, Vanaporn Wuthiekanun, Wirongrong Chierakul, Stuart D Blacksell, Nicholas P Day, Achara Laongnualpanich, Daniel H Paris
BACKGROUND: Tropical infectious diseases like dengue, scrub typhus, murine typhus, leptospirosis, and enteric fever continue to contribute substantially to the febrile disease burden throughout Southeast Asia while malaria is declining. Recently, there has been increasing focus on biomarkers (i.e. C-reactive protein (CRP) and procalcitonin) in delineating bacterial from viral infections. METHODOLOGY/PRINCIPAL FINDINGS: A prospective observational study was performed to investigate the causes of acute undifferentiated fever (AUF) in adults admitted to Chiangrai Prachanukroh hospital, northern Thailand, which included an evaluation of CRP and procalcitonin as diagnostic tools...
May 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29843713/development-of-a-high-throughput-flexible-quantitative-suspension-array-assay-for-igg-against-multiple-plasmodium-falciparum-antigens
#5
Itziar Ubillos, Joseph J Campo, Alfons Jiménez, Carlota Dobaño
BACKGROUND: Antibody responses to Plasmodium falciparum play a critical role in disease control. Finding reliable IgG biomarkers of protection is complicated by a parasite proteome of over 5000 proteins, some with polymorphisms. Studies of anti-malarial naturally acquired and vaccine immunity would benefit from a standard high-throughput immunoassay to measure multiple antibodies. A multiplex quantitative suspension assay to measure antigen-specific IgGs was developed and its precision (reproducibility and repeatability), dynamic range, limits of detection and quantification, and non-specific binding to different P...
May 29, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29784862/antibodies-to-icam1-binding-pfemp1-dbl%C3%AE-are-biomarkers-of-protective-immunity-to-malaria-in-a-cohort-of-young-children-from-papua-new-guinea
#6
Sofonias K Tessema, Digjaya Utama, Olga Chesnokov, Anthony N Hodder, Clara S Lin, G L Abby Harrison, Jakob S Jespersen, Bent Petersen, Livingstone Tavul, Peter Siba, Dominic Kwiatkowski, Thomas Lavstsen, Diana S Hansen, Andrew V Oleinikov, Ivo Mueller, Alyssa E Barry
Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) mediates parasite sequestration to the cerebral microvasculature via binding of DBLβ domains to Intercellular Adhesion Molecule 1 (ICAM1) and is associated with severe cerebral malaria. In a cohort of 187 young children from Papua New Guinea (PNG), we examined baseline antibody levels to the ICAM1-binding PfEMP1 domain, DBLβ3PF11_0521 , in comparison to four control antigens including NTS-DBLα and CIDR1 domains from another group A variant and a group B/C variant...
May 21, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29783973/erythrocyte-microrna-sequencing-reveals-differential-expression-in-relapsing-remitting-multiple-sclerosis
#7
Kira Groen, Vicki E Maltby, Rodney A Lea, Katherine A Sanders, J Lynn Fink, Rodney J Scott, Lotti Tajouri, Jeannette Lechner-Scott
BACKGROUND: There is a paucity of knowledge concerning erythrocytes in the aetiology of Multiple Sclerosis (MS) despite their potential to contribute to disease through impaired antioxidant capacity and altered haemorheological features. Several studies have identified an abundance of erythrocyte miRNAs and variable profiles associated with disease states, such as sickle cell disease and malaria. The aim of this study was to compare the erythrocyte miRNA profile of relapsing-remitting MS (RRMS) patients to healthy sex- and age-matched controls...
May 21, 2018: BMC Medical Genomics
https://www.readbyqxmd.com/read/29760095/volatile-biomarkers-of-symptomatic-and-asymptomatic-malaria-infection-in-humans
#8
Consuelo M De Moraes, Caroline Wanjiku, Nina M Stanczyk, Hannier Pulido, James W Sims, Heike S Betz, Andrew F Read, Baldwyn Torto, Mark C Mescher
Malaria remains among the world's deadliest diseases, and control efforts depend critically on the availability of effective diagnostic tools, particularly for the identification of asymptomatic infections, which play a key role in disease persistence and may account for most instances of transmission but often evade detection by current screening methods. Research on humans and in animal models has shown that infection by malaria parasites elicits changes in host odors that influence vector attraction, suggesting that such changes might yield robust biomarkers of infection status...
May 14, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29757416/early-changes-in-cd4-t-cell-activation-following-blood-stage-plasmodium-falciparum-infection
#9
Chelsea L Edwards, Susanna S Ng, Dillon Corvino, Marcela Montes de Oca, Fabian de Labastida Rivera, Katia Nones, Vanessa Lakis, Nicola Waddell, Fiona H Amante, James S McCarthy, Christian R Engwerda
We examined transcriptional changes in CD4+ T cells during blood-stage Plasmodium falciparum infection in individuals without a history of previous parasite exposure. CD4+ T cell CXCL8 gene (encoding IL-8) transcription was identified as an early biomarker of sub-microscopic P. falciparum infection, with predictive power for parasite growth. Following anti-parasitic drug treatment, a CD4+ T cell regulatory phenotype developed. PD1 expression on CD49b+ CD4+ T (putative type I regulatory (Tr1)) cells after drug treatment negatively correlated with earlier parasite growth...
May 11, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29733403/effects-of-weekly-iron-and-folic-acid-supplements-on-malaria-risk-in-nulliparous-women-in-burkina-faso-a-periconceptional-double-blind-randomized-controlled-non-inferiority-trial
#10
Sabine Gies, Salou Diallo, Stephen A Roberts, Adama Kazienga, Matthew Powney, Loretta Brabin, Sayouba Ouedraogo, Dorine W Swinkels, Anneke J Geurts-Moespot, Yves Claeys, Umberto D'Alessandro, Halidou Tinto, Brian Faragher, Bernard Brabin
Background: Safety of iron supplementation for young women is uncertain in malaria endemic settings. Methods: Double-blind randomized controlled non-inferiority trial in rural Burkina Faso. Results: 1959 nulliparae assigned to weekly supplementation (60 mg iron and 2.8 mg folic acid) (n=980) or 2.8 mg folic acid (n=979) until first antenatal visit (ANC1), or 18 months if remaining non-pregnant. 315 women attended ANC1, and 916 remained non-pregnant...
May 4, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29690924/the-effect-of-regularly-dosed-paracetamol-versus-no-paracetamol-on-renal-function-in-plasmodium-knowlesi-malaria-packnow-study-protocol-for-a-randomised-controlled-trial
#11
Daniel J Cooper, Katherine Plewes, Matthew J Grigg, Giri S Rajahram, Kim A Piera, Timothy William, Mark D Chatfield, Tsin Wen Yeo, Arjen M Dondorp, Nicholas M Anstey, Bridget E Barber
BACKGROUND: Plasmodium knowlesi is the most common cause of human malaria in Malaysia. Acute kidney injury (AKI) is a frequent complication. AKI of any cause can have long-term consequences, including increased risk of chronic kidney disease, adverse cardiovascular events and increased mortality. Additional management strategies are therefore needed to reduce the frequency and severity of AKI in malaria. In falciparum malaria, cell-free haemoglobin (CFHb)-mediated oxidative damage contributes to AKI...
April 24, 2018: Trials
https://www.readbyqxmd.com/read/29669942/cxcl10-stabilizes-t-cell-brain-endothelial-cell-adhesion-leading-to-the-induction-of-cerebral-malaria
#12
Elizabeth W Sorensen, Jeffrey Lian, Aleksandra J Ozga, Yoshishige Miyabe, Sophina W Ji, Shannon K Bromley, Thorsten R Mempel, Andrew D Luster
Malaria remains one of the world's most significant human infectious diseases and cerebral malaria (CM) is its most deadly complication. CM pathogenesis remains incompletely understood, hindering the development of therapeutics to prevent this lethal complication. Elevated levels of the chemokine CXCL10 are a biomarker for CM, and CXCL10 and its receptor CXCR3 are required for experimental CM (ECM) in mice, but their role has remained unclear. Using multiphoton intravital microscopy, CXCR3 receptor- and ligand-deficient mice and bone marrow chimeric mice, we demonstrate a key role for endothelial cell-produced CXCL10 in inducing the firm adhesion of T cells and preventing their cell detachment from the brain vasculature...
April 19, 2018: JCI Insight
https://www.readbyqxmd.com/read/29596409/distinct-inflammatory-profile-underlies-pathological-increases-in-creatinine-levels-associated-with-plasmodium-vivax-malaria-clinical-severity
#13
Luís A B Cruz, Manoel Barral-Netto, Bruno B Andrade
BACKGROUND: Although Plasmodium vivax infection is a frequent cause of malaria worldwide, severe presentations have been more regularly described only in recent years. In this setting, despite clinical descriptions of multi-organ involvement, data associating it with kidney dysfunction are relatively scarce. Here, renal dysfunction is retrospectively analyzed in a large cohort of vivax malaria patients with an attempt to dissect its association with disease severity and mortality, and to determine the role of inflammation in its progression...
March 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29581051/febrile-illness-in-asia-gaps-in-epidemiology-diagnosis-and-management-for-informing-health-policy
#14
REVIEW
P Shrestha, T Roberts, A Homsana, T O Myat, J A Crump, Y Lubell, P N Newton
BACKGROUND: Increasing evidence is becoming available on the aetiology and management of fevers in Asia; the importance of these fevers has increased with the decline in the incidence of malaria. AIMS: To conduct a narrative review of the epidemiology and management of fevers in South and South-East Asia and to highlight gaps in our knowledge that impair evidence-based health policy decisions. SOURCES: A narrative review of papers published since 2012 on developments in fever epidemiology, diagnosis and treatment in South and South-East Asia...
March 23, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29578181/identification-of-key-genes-related-to-high-risk-gastrointestinal-stromal-tumors-using-bioinformatics-analysis
#15
Shuan Jin, Wenhua Zhu, Jun Li
Aim: The purpose of this study was to identify predictive biomarkers used for clinical therapy and prognostic evaluation of high-risk gastrointestinal stromal tumors (GISTs). Materials and Methods: In this study, microarray data GSE31802 were used to identify differentially expressed genes (DEGs) between high-risk GISTs and low-risk GISTs. Then, enrichment analysis of DEGs was conducted based on the gene ontology and kyoto encyclopedia of genes and genomes pathway database...
2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29557342/characterization-of-plasmodium-lactate-dehydrogenase-and-histidine-rich-protein-2-clearance-patterns-via-rapid-on-bead-detection-from-a-single-dried-blood-spot
#16
Christine F Markwalter, Lauren E Gibson, Lwiindi Mudenda, Danielle W Kimmel, Saidon Mbambara, Philip E Thuma, David W Wright
A rapid, on-bead enzyme-linked immunosorbent assay for Plasmodium lactate dehydrogenase ( p LDH) and Plasmodium falciparum histidine-rich protein 2 (HRP2) was adapted for use with dried blood spot (DBS) samples. This assay detected both biomarkers from a single DBS sample with only 45 minutes of total incubation time and detection limits of 600 ± 500 pM ( p LDH) and 69 ± 30 pM (HRP2), corresponding to 150 and 24 parasites/μL, respectively. This sensitive and reproducible on-bead detection method was used to quantify p LDH and HRP2 in patient DBS samples from rural Zambia collected at multiple time points after treatment...
May 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29519240/lactate-clearance-as-a-prognostic-marker-of-mortality-in-severely-ill-febrile-children-in-east-africa
#17
A Aramburo, Jim Todd, Elizabeth C George, Sarah Kiguli, Peter Olupot-Olupot, Robert O Opoka, Charles Engoru, Samuel O Akech, Richard Nyeko, George Mtove, Diana M Gibb, Abdel G Babiker, Kathryn Maitland
BACKGROUND: Hyperlactataemia (HL) is a biomarker of disease severity that predicts mortality in patients with sepsis and malaria. Lactate clearance (LC) during resuscitation has been shown to be a prognostic factor of survival in critically ill adults, but little data exist for African children living in malaria-endemic areas. METHODS: In a secondary data analysis of severely ill febrile children included in the Fluid Expansion as Supportive Therapy (FEAST) resuscitation trial, we assessed the association between lactate levels at admission and LC at 8 h with all-cause mortality at 72 h (d72)...
March 9, 2018: BMC Medicine
https://www.readbyqxmd.com/read/29515150/detection-of-the-malaria-causing-plasmodium-parasite-in-saliva-from-infected-patients-using-topoisomerase-i-activity-as-a-biomarker
#18
Marianne Smedegaard Hede, Søren Fjelstrup, Felix Lötsch, Rella Manego Zoleko, Anna Klicpera, Mirjam Groger, Johannes Mischlinger, Lilian Endame, Luzia Veletzky, Ronja Neher, Anne Katrine Wrist Simonsen, Eskild Petersen, Ghyslain Mombo-Ngoma, Magnus Stougaard, Yi-Ping Ho, Rodrigo Labouriau, Michael Ramharter, Birgitta Ruth Knudsen
Malaria is among the major threats to global health with the main burden of disease being in rural areas of developing countries where accurate diagnosis based on non-invasive samples is in high demand. We here present a novel molecular assay for detection of malaria parasites based on technology that may be adapted for low-resource settings. Moreover, we demonstrate the exploitation of this assay for detection of malaria in saliva. The setup relies on pump-free microfluidics enabled extraction combined with a DNA sensor substrate that is converted to a single-stranded DNA circle specifically by topoisomerase I expressed by the malaria causing Plasmodium parasite...
March 7, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29512479/evaluation-of-malaria-urban-risk-using-an-immuno-epidemiological-biomarker-of-human-exposure-to-anopheles-bites
#19
Dipomin F Traoré, André B Sagna, Akré M Adja, Dounin D Zoh, Kouassi N Lingué, Issa Coulibaly, Bertin N'Cho Tchiekoi, Serge B Assi, Anne Poinsignon, Mamadou Dagnogo, Franck Remoue
Urban malaria is an underestimated serious health concern in African countries. This study aimed to evaluate the risk of malaria transmission in an urban area by evaluating the level of human exposure to Anopheles bites using an Anopheles salivary biomarker ( gambiae Salivary Gland Protein-6 peptide 1 [gSG6-P1] peptide). Two multidisciplinary cross-sectional studies were undertaken in five sites of Bouaké city (three urban districts and two surrounding villages, used as control; Côte d'Ivoire) during the rainy season and the dry season...
May 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29511216/direct-detection-of-unamplified-pathogen-rna-in-blood-lysate-using-an-integrated-lab-in-a-stick-device-and-ultrabright-sers-nanorattles
#20
Hoan T Ngo, Elizabeth Freedman, Ren Abelard Odion, Pietro Strobbia, Agampodi Swarnapali De Silva Indrasekara, Priya Vohra, Steve M Taylor, Tuan Vo-Dinh
Direct detection of genetic biomarkers in body fluid lysate without target amplification will revolutionize nucleic acid-based diagnostics. However, the low concentration of target sequences makes this goal challenging. We report a method for direct detection of pathogen RNA in blood lysate using a bioassay using surface-enhanced Raman spectroscopy (SERS)-based detection integrated in a "lab-in-a-stick" portable device. Two levels of signal enhancement were employed to achieve the sensitivity required for direct detection...
March 6, 2018: Scientific Reports
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