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https://www.readbyqxmd.com/read/28109191/serum-high-concentrations-of-homocysteine-and-low-levels-of-folic-acid-and-vitamin-b12-are-significantly-correlated-with-the-categories-of-coronary-artery-diseases
#1
Yan Ma, Duanliang Peng, Chenggui Liu, Chen Huang, Jun Luo
BACKGROUND: Homocysteine (Hcy) has been considered as an independent risk factor for coronary artery disease (CAD). Folic acid and vitamin B12 are two vital regulators in Hcy metabolic process. We evaluated the correlations between serum Hcy, folic acid and vitamin B12 with the categories of CAD. METHODS: Serum Hcy, folic acid and vitamin B12 from 292 CAD patients, including 73 acute myocardial infarction (AMI), 116 unstable angina pectoris (UAP), 103 stable angina pectoris (SAP), and 100 controls with chest pain patients were measured, and the data were analyzed by SPSS software...
January 21, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28109182/are-home-visits-an-effective-method-for-diabetes-management-a-quantitative-systematic-review-and-meta-analysis
#2
Lin Han, Yuxia Ma, Suhong Wei, Jinhui Tian, Xiaochun Yang, Xiping Shen, Jun Zhang, Yuexian Shi
AIMS: Previous reviews have revealed uncertainty regarding the effectiveness of home visit interventions for managing diabetes. Therefore, we performed a quantitative systematic review and meta-analysis to evaluate the effects of home visit interventions among patients with diabetes. METHODS: We searched various electronic databases (PubMed, EMBASE, Cochrane Library, Web of Science, CINAHL, Wanfang, and Chinese scientific full-text databases) from their inception until March 2016...
January 21, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28109179/quantitative-and-integrative-analysis-of-paracrine-hepatocyte-activation-by-non-parenchymal-cells-upon-lipopolysaccharide-induction
#3
Katharina Beuke, Frank A Schildberg, Federico Pinna, Ute Albrecht, Roman Liebe, Michaela Bissinger, Peter Schirmacher, Steven Dooley, Johannes G Bode, Percy A Knolle, Ursula Kummer, Kai Breuhahn, Sven Sahle
Gut-derived bacterial lipopolysaccharides (LPS) stimulate the secretion of tumor necrosis factor (TNF) from liver macrophages (MCs), liver sinusoidal endothelial cells (LSECs), and hepatic stellate cells (HSCs), which control the acute phase response in hepatocytes through activation of the NF-κB pathway. The individual and cooperative impact of non-parenchymal cells on this clinically relevant response has not been analysed in detail due to technical limitations. To gain an integrative view on this complex inter- and intracellular communication, we combined a multi-scale mathematical model with quantitative, time-resolved experimental data of different primary murine liver cell types...
January 21, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28109042/expression-and-characterization-of-a-codon-optimized-blood-coagulation-factor-viii
#4
S A Shestopal, J-J Hao, E Karnaukhova, Y Liang, M V Ovanesov, M Lin, J H Kurasawa, T K Lee, J H McVey, A G Sarafanov
BACKGROUND: Production of recombinant factor VIII (FVIII) is challenging due to its low expression. It was previously shown that codon-optimization of a B domain-deleted FVIII (BDD-FVIII) cDNA resulted in increased protein expression. However, it is well-recognized that synonymous mutations may affect the protein structure and function. OBJECTIVES: To compare biochemical properties of a BDD-FVIII expressed from codon-optimized (CO) and the wild-type (WT) cDNAs. METHODS: Each variant of the BDD-FVIII was expressed in several independent CHO cell lines, generated using a lentiviral platform...
January 21, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28109022/itpa-polymorphism-correlates-with-the-reductions-in-hemoglobin-concentration-and-ribavirin-dose-during-sofosbuvir-and-ribavirin-therapy
#5
Ritsuzo Kozuka, Hoang Hai, Yuga Teranishi, Hiroyuki Motoyama, Etsushi Kawamura, Atsushi Hagihara, Sawako Uchida-Kobayashi, Hiroyasu Morikawa, Masaru Enomoto, Yoshiki Murakami, Norifumi Kawada, Akihiro Tamori
BACKGROUND AND AIM: It is unclear whether polymorphism in the inosine triphosphatase (ITPA) gene correlates with the reduction in hemoglobin (Hb) concentrations during sofosbuvir (SOF) and ribavirin (RBV) therapy. We investigated the effects of the ITPA polymorphism in Japanese patients with chronic hepatitis C virus genotype 2 infection treated with SOF/RBV therapy. METHODS: In 106 patients treated with SOF/RBV therapy, we assessed the effects of the ITPA polymorphism (rs1127354) on anemia, RBV dose reduction, and sustained virological response (SVR)...
January 20, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28108922/association-between-heavy-metal-and-metalloid-levels-in-topsoil-and-cancer-mortality-in-spain
#6
Olivier Núñez, Pablo Fernández-Navarro, Iván Martín-Méndez, Alejandro Bel-Lan, Juan F Locutura Rupérez, Gonzalo López-Abente
Spatio-temporal cancer mortality studies in Spain have revealed patterns for some tumours which display a distribution that is similar across the sexes and persists over time. Such characteristics would be common to tumours that shared risk factors, including the geochemical composition of the soil. The aim of this study was to assess the possible association between heavy metal and metalloid levels in topsoil (upper soil horizon) and cancer mortality in mainland Spain. Ecological cancer mortality study at a municipal level, covering 861,440 cancer deaths (27 different tumour locations) in 7917 Spanish mainland towns, from 1999 to 2008...
January 20, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28108908/diamine-oxidase-from-white-pea-lathyrus-sativus-combined-with-catalase-protects-the-human-intestinal-caco-2-cell-line-from-histamine-damage
#7
Catherine Jumarie, Marilyne Séïde, Lucia Marcocci, Paola Pietrangeli, Mircea Alexandru Mateescu
Diamine oxidase (DAO) administration has been proposed to treat certain gastrointestinal dysfunctions induced by histamine, an immunomodulator, signaling, and pro-inflammatory factor. However, H2O2 resulting from the oxidative deamination of histamine by DAO may be toxic. The purpose of this study was to investigate to which extent DAO from white pea (Lathyrus sativus), alone or in combination with catalase, may modulate histamine toxicity in the human intestinal Caco-2 cell line. The results show that histamine at concentrations higher than 1 mM is toxic to the Caco-2 cells, independently of the cell differentiation status, with a LC50 of ≅ 10 mM following a 24-h exposure...
January 20, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28108888/biofilm-phosphorus-uptake-capacity-as-a-tool-for-the-assessment-of-pollutant-effects-in-river-ecosystems
#8
Lorenzo Proia, Anna Romaní, Sergi Sabater
Biofilms are a key component in the nutrient removal from the water column. However, nutrient uptake by biofilms may be hampered by the occurrence of pollutants or other stressors. This study aimed: (i) to investigate the biofilm phosphorus (P) uptake capacity as a relevant process for the maintenance of fluvial water quality and (ii) to explore the sensitivity of this process to different chemical and environmental stressors. We conducted chamber experiments to test for the relevance of biofilm P uptake capacity (PUC) as a tool to detect effects of pollutants on river self-depuration...
January 21, 2017: Ecotoxicology
https://www.readbyqxmd.com/read/28108701/willingness-to-use-and-have-sex-with-men-taking-hiv-pre-exposure-prophylaxis-prep-results-of-online-surveys-of-australian-gay-and-bisexual-men-2011-2015
#9
Martin Holt, Toby Lea, Heather-Marie Schmidt, Johann Kolstee, Jeanne Ellard, Dean Murphy, Hong-Ha Truong, John de Wit
OBJECTIVE: Assess willingness to use HIV pre-exposure prophylaxis (PrEP), support for others using it and willingness to have sex with partners using PrEP among Australian gay and bisexual men (GBM). METHODS: National, online cross-sectional surveys of Australian GBM were conducted in 2011, 2013 and 2015. Scales measuring support for and willingness to have sex with men using PrEP were developed in 2015 using factor analysis. Trends and associations with key measures were analysed using multivariate logistic regression...
January 20, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28108611/reversal-of-diabetes-in-nod-mice-by-clinical-grade-proinsulin-and-il-10-secreting-lactococcus-lactis-in-combination-with-low-dose-anti-cd3-depends-on-the-induction-of-foxp3-positive-t-cells
#10
Tatiana Takiishi, Dana Paulina Cook, Hannelie Korf, Guido Sebastiani, Francesca Mancarella, João Paulo Monteiro Carvalho Mori Cunha, Clive Wasserfall, Noelia Casares, Juan José Lasarte, Lothar Steidler, Pieter Rottiers, Francesco Dotta, Conny Gysemans, Chantal Mathieu
The introduction of β-cell autoantigens via the gut through Lactococcus lactis (L. lactis) has been demonstrated to be a promising approach for diabetes reversal in NOD mice. Here we show that a combination therapy of low-dose anti-CD3 with a clinical-grade self-containing L. lactis, appropriate for human application, secreting human proinsulin and interleukin-10, cured 66% of mice with new-onset diabetes, which is comparable to therapy results with plasmid-driven L. lactis Initial blood glucose concentrations (<350 mg/dL) and insulin autoantibody positivity were predictors of the stable reversal of hyperglycemia, and decline in insulin autoantibody positivity was an immune biomarker of therapeutic outcome...
February 2017: Diabetes
https://www.readbyqxmd.com/read/28108549/relation-of-renal-dysfunction-with-incident-atrial-fibrillation-and-cardiovascular-morbidity-and-mortality-the-prevend-study
#11
Ernaldo G Marcos, Bastiaan Geelhoed, Pim Van Der Harst, Stefan J L Bakker, Ron T Gansevoort, Hans L Hillege, Isabelle C Van Gelder, Michiel Rienstra
AIMS: Renal dysfunction is a risk factor for cardiovascular disease, including atrial fibrillation (AF) and mortality. However, the exact pathobiology linking different renal dysfunction measures, such as albumin excretion or glomerular filtration rate (GFR), to cardiovascular- and AF risk are unclear. In this study, we investigated the association of several renal function measures and incident AF, and whether the relation between renal measures and outcomes is modified by AF. METHODS AND RESULTS: We examined 8265 individuals (age 49 ± 13 years, 50% women) included in the PREVEND study...
January 20, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28108513/relb-expression-determines-the-differential-effects-of-ascorbic-acid-in-normal-and-cancer-cells
#12
Xiaowei Wei, Yong Xu, Fang Fang Xu, Luksana Chaiswing, David Schnell, Teresa Noel, Chi Wang, Jinfei Chen, Daret K St Clair, William H St Clair
Cancer cells typically experience higher oxidative stress than normal cells, such that elevating pro-oxidant levels can trigger cancer cell death. Although pre-exposure to mild oxidative agents will sensitize cancer cells to radiation, this pre-exposure may also activate the adaptive stress defense system in normal cells. Ascorbic acid (AA) is a prototype redox modulator that when infused intravenously appears to kill cancers without injury to normal tissues; however, the mechanisms involved remain elusive...
January 20, 2017: Cancer Research
https://www.readbyqxmd.com/read/28108285/rifampin-suppresses-osteoclastogenesis-and-titanium-particle-induced-osteolysis-via-modulating-rankl-signaling-pathways
#13
Liang Zhu, Hui Kang, Chang-An Guo, Wen-Shuai Fan, Yi-Ming Wang, Lian-Fu Deng, Zuo-Qin Yan
BACKGROUND: Wear particles liberated from the surface of prostheses are considered to be main reason for osteoclast bone resorption and that extensive osteoclastogenesis leads to peri-implant osteolysis and subsequent prosthetic loosening. The aim of this study was to assess the effect of rifampin on osteoclastogenesis and titanium (Ti) particle-induced osteolysis. METHODS: The Ti particle-induced osteolysis mouse calvarial model and bone marrow-derived macrophages (BMMs) were used...
January 17, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28108223/involvement-of-the-antioxidative-property-of-morusin-in-blocking-phorbol-ester-induced-malignant-transformation-of-jb6-p-mouse-epidermal-cells
#14
Pai-Shan Cheng, Chao-Chin Hu, Chau-Jong Wang, Yean-Jang Lee, Wei-Chia Chung, Tsui-Hwa Tseng
Chemoprevention has been acknowledged as an important and practical strategy for managing cancer. We have previously synthesized morusin, a prenylated flavonoid that exhibits anti-cancer progression activity. In the present study, we evaluated the anti-cancer promotion potential of morusin by using the mouse epidermal JB6 P(+) cell model. Extensive evidence shows that tumor promotion by phorbol esters is due to the stimulation of reactive oxygen species (ROS). Therefore, the effect of morusin on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ROS production was assessed...
January 17, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28107986/dispersive-solid-phase-extraction-using-polyaniline-modified-zeolite-nay-as-a-new-sorbent-for-multiresidue-analysis-of-pesticides-in-food-and-environmental-samples
#15
Prapha Arnnok, Nopbhasinthu Patdhanagul, Rodjana Burakham
The applicability of polyaniline (PANI)-modified zeolite NaY as a sorbent for multi-class pesticides extraction was investigated. The sorbent had a sorption capacity of 833mgkg(-1) sorbent and preconcentration factor of 42 in the mixture of twenty pesticides. The PANI-coated zeolite NaY was successfully created via oxidative polymerization of aniline onto the surface of the zeolite. The sorbent was applied for dispersive solid phase extraction (DSPE) of commonly used pesticides belonging to five different chemical groups, involving carbamate, organophosphate, sulfonylurea, pyrethroid and neonicotinoid...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28107917/binding-induced-strand-displacement-amplification-for-homogeneous-protein-assay
#16
Yubin Li, Sheng Liu, Zike Zhao, Yuner Zheng, Zirui Wang
An ultrasensitive and homogenous strategy for protein assay was established based upon binding-induced strand displacement amplification (BI-SDA). Binding-Induced DNA strand-displacement occurred between Apt-T•signal DNA and Apt-C, and release of signal DNA upon addition of platelet-derived growth factor (PDGF BB). The released signal DNA further hybridized with multifunctional hairpin DNA probe and induced the strand-displacement amplification in the presence of Klenow Fragment (exo(-)) and dNTPs. The BI-SDA product contain G-quaruplex DNA, which could be recognized and reported by the fluorescence of fluorochrome N-methyl porphyrin propionic acid IX (NMM)...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28107914/development-of-amino-functionalized-carbon-coated-magnetic-nanoparticles-and-their-application-to-electrochemical-detection-of-hybridization-of-nucleic-acids
#17
Cansu Altay, R Hilal Senay, Ece Eksin, Gulsah Congur, Arzum Erdem, Sinan Akgol
In our study, the development of amino functionalized carbon coated magnetic nanoparticles (NH2-CC-MNPs) and their usage for electrochemical detection of hybridization of nucleic acids have been aimed. Firstly, NH2-CC-MNPs were prepared by coating of pristine Fe3O4 nanoparticles with two layers via caramelization and silanization processes respectively. After the morphological characterization with scanning electron microscopy (SEM) it was seen that NH2-CC-MNPs was spherical shaped and in 28nm sized. Investigation of chemical composition with the help of scanning electron microscopy/energy dispersive X-ray spectroscopy (SEM/EDX) and fourier transform infrared spectroscopy (FTIR) was showed incorporation of carbon and APTES to the structure of NH2-CC-MNPs...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28107678/nobiletin-and-its-colonic-metabolites-suppress-colitis-associated-colon-carcinogenesis-by-down-regulating-inos-inducing-antioxidative-enzymes-and-arresting-cell-cycle-progression
#18
Xian Wu, Mingyue Song, Zili Gao, Yue Sun, Minqi Wang, Fang Li, Jinkai Zheng, Hang Xiao
Nobiletin (NOB) is a major citrus polymethoxyflavone (PMF) with various beneficial biological activities. We reported previously that dietary NOB significantly inhibited colitis-associated colon carcinogenesis in azoxymethane (AOM)/dextran sulfate sodium (DSS)-treated mice, and the chemopreventive effects were associated with NOB metabolites found in the mouse colonic tissues. In this study, to better understand the role of colonic metabolites of NOB, we determined the anti-inflammation and anticancer effects of a mixture of NOB and its major metabolites (NOB-Met) at the concentrations equivalent to those found in colonic tissues of NOB-fed mice...
January 11, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28107663/antibacterial-anti-oxidant-electroactive-injectable-hydrogel-as-self-healing-wound-dressing-with-hemostasis-and-adhesiveness-for-cutaneous-wound-healing
#19
Xin Zhao, Hao Wu, Baolin Guo, Ruonan Dong, Yusheng Qiu, Peter X Ma
Injectable self-healing hydrogel dressing with multifunctional properties including anti-infection, anti-oxidative and conductivity promoting wound healing process will be highly desired in wound healing application and its design is still a challenge. We developed a series of injectable conductive self-healed hydrogels based on quaternized chitosan-g-polyaniline (QCSP) and benzaldehyde group functionalized poly(ethylene glycol)-co-poly(glycerol sebacate) (PEGS-FA) as antibacterial, anti-oxidant and electroactive dressing for cutaneous wound healing...
January 11, 2017: Biomaterials
https://www.readbyqxmd.com/read/28107421/peroxiporin-expression-is-an-important-factor-for-cancer-cell-susceptibility-to-therapeutic-h2o2-implications-for-pharmacological-ascorbate-therapy
#20
Dieanira Erudaitius, Andrew Huang, Sarah Kazmi, Garry R Buettner, Victor G J Rodgers
Cancer cell toxicity to therapeutic H2O2 varies widely depending on cell type. Interestingly, it has been observed that different cancer cell types have varying peroxiporin expression. We hypothesize that variation in peroxiporin expression can alter cell susceptibility to therapeutic H2O2 concentrations. Here, we silence peroxiporin aquaporin-3 (AQP3) on the pancreatic cancer cell line MIA PaCa-2 and compare clonogenic survival response to the wild-type. The results showed a significantly higher surviving fraction in the clonogenic response for siAQP3 MIA PaCa-2 cells at therapeutic H2O2 doses (P < 0...
2017: PloS One
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