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https://www.readbyqxmd.com/read/28454485/cheminformatics-based-anticoagulant-study-of-traditionally-used-medicinal-plants
#1
Mahdi Alikhani Pour, Soroush Sardari, Ali Eslamifar, Abid Azhar, Mohammad Rezvani, Milad Nazari
Backgroung: Medicinal plants, as a complementary medicine, have been used to treat various diseases since ancient times. These plants have numerous beneficial applications and are the source of certain conventional drugs. In diseases such as stroke and ischemia, which are caused by several factors, abnormal coagulation is an important causative factor. Accordingly, novel and effective therapies such as herbal remedies should be practiced to prevent such lethal diseases. Methods: Using the available databases such as Google Scholar and PubMed, the previously reported anticoagulant compounds and plants possessing anticoagulant activity were identified and collected in two separate lists...
April 29, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28454472/hsp90-inhibitor-sy-016-induces-g2-m-arrest-and-apoptosis-in-paclitaxel-resistant-human-ovarian-cancer-cells
#2
Hyun Gyo Lee, Won Jin Park, So Jin Shin, Sang Hoon Kwon, Soon Do Cha, Young Ho Seo, Ju Hui Jeong, Ji Yoon Lee, Chi Heum Cho
The aim of the present study was to evaluate the in vitro effect of a heat shock protein (Hsp)90 inhibitor, SY-016, on the paclitaxel (PTX)-resistant human ovarian cancer cell line OVCAR-3PTX, and explore its mechanism of apoptosis. In the present study, SY-016 was used in combination with PTX to determine its effect on the cell proliferation and apoptosis of OVCAR-3PTX cells. The drug-resistant tumor cells were established in vitro by stepwise sequential exposure to increasing concentrations of PTX. The cell viability and cell cycle distribution were measured by MTT assay and flow cytometric analysis, respectively...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454460/melatonin-treatment-induces-apoptosis-through-regulating-the-nuclear-factor-%C3%AE%C2%BAb-and-mitogen-activated-protein-kinase-signaling-pathways-in-human-gastric-cancer-sgc7901-cells
#3
Weimin Li, Zhonglue Wang, Yina Chen, Kaijing Wang, Ting Lu, Fei Ying, Mengdi Fan, Zhiyin Li, Jiansheng Wu
Melatonin, which is synthesized by the pineal gland and released into the blood, exhibits antitumor properties. However, the mechanisms underlying these effects, particularly in stomach cancer, remain unknown. In the present study, the effect of melatonin on the nuclear factor (NF)-κB signaling pathway and the mitogen-activated protein kinase signaling pathway, involving p38 and c-Jun-N-terminal kinase (JNK), were investigated in SGC7901 gastric cancer cells. In addition, the effect of melatonin on the survival, migration and apoptosis of these cells was investigated in vitro in order to evaluate the use of melatonin for the treatment of gastric cancer...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454351/the-role-of-quercetin-and-vitamin-c-in-nrf2-dependent-oxidative-stress-production-in-breast-cancer-cells
#4
Zohreh Mostafavi-Pour, Fatemeh Ramezani, Fatemeh Keshavarzi, Nasser Samadi
The balance between the production and elimination of reactive oxygen species (ROS) is essential in determining whether cells survive or undergo apoptosis. Nuclear factor erythroid 2-related factor 2 (Nrf2) may act as a sensor for electrophilic stress, thus regulating the intracellular antioxidant response. The present study investigated the role of vitamin C (VC) and quercetin (Q) in the induction of Nrf2-mediated oxidative stress in cancer cells. An MTT assay was conducted to examine the anti-proliferative effects of VC and Q...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454335/effect-of-laser-therapy-on-plasma-expression-of-vegf-and-bfgf-in-infants-with-cutaneous-hemangioma
#5
Fagang Wang, Rongjian Xu, Qian Xu, Yongqian Cao, Li Lin, Wei Dang
The present study aimed to investigate the effect of laser therapy on the expression of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in the plasma of infants diagnosed with cutaneous hemangioma, in order to identify biomarkers for assessing the clinical efficacy of laser therapy. In total, 109 infants with superficial abdominal hemangioma received laser treatment, of which 74 were diagnosed in the proliferation phase, 20 in the regression phase and 15 in the involution phase...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454284/anti-apoptotic-protein-lifeguard-does-not-act-as-a-tumor-marker-in-breast-cancer
#6
Viktor Maurer, Kerstin Reimers, Hans J Lück, Peter M Vogt, Vesna Bucan
The aim of the present study was to use an enzyme-linked immunosorbent assay (ELISA) to determine the concentrations of Lifeguard (LFG) protein in the serum of 36 patients diagnosed with breast cancer and to compare these values with the concentrations of LFG protein in the serum of 7 healthy volunteers in order to detect a possible association between the expression of LFG in the serum and the degree of malignancy of the disease. Although there is no direct association between the LFG protein concentration in the serum and the degree of malignancy of breast cancer, a statistically significant distribution of the concentration in all investigated samples was observed...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454271/intracellular-and-extracellular-factors-influencing-the-genotoxicity-of-nitric-oxide-and-reactive-oxygen-species
#7
Min Young Kim
A number of factors affect cellular responses to nitric oxide (NO(•)) and reactive oxygen species (ROS), including their source, concentration, cumulative dose, target gene and biological milieu. This limits the extrapolation of data to in vivo pathological states in which NO(•) and ROS may be important. The present study investigated lethality and mutagenesis in the HPRT and TK1 genes of human lymphoblastoid TK6 cells exposed to NO(•) and ROS derived from two delivery methods: A reactor system and a Transwell™ co-culture...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454260/k9-c4h4fn2o2-2nd-pw11o39-2%C3%A2-25h2o-induces-apoptosis-in-human-lung-cancer-a549-cells
#8
Rong-Yao Xia, Ran-Ran Zhang, Zhe Jiang, Ya-Jiao Sun, Jing Liu, Fu-Hui Chen
Lung cancer is the leading cause of cancer-associated mortality worldwide. The present study investigated the effects of K9(C4H4FN2O2)2Nd(PW11O39)2·25H2O (FNdPW), a chemically synthesized polyoxometalate that contains rare earth elements, on lung cancer growth, and explored the mechanism underlying its actions. The effects of FNdPW on the cell viability and apoptosis of human lung cancer A549 cells were measured using MTT assay, acridine orange/ethidium bromide staining and electron microscopy. The expression of apoptosis-related proteins, including B-cell lymphoma (Bcl)-2-associated death promoter (Bad), phosphorylated (p)-Bad, X-linked inhibitor of apoptosis (XIAP), apoptosis-inducing factor (AIF), Bcl-2-associated X protein (Bax) and Bcl-2, was determined by western blotting...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454077/comparison-of-ftir-atr-and-raman-spectroscopy-in-determination-of-vldl-triglycerides-in-blood-serum-with-pls-regression
#9
Adam Oleszko, Jadwiga Hartwich, Anna Wójtowicz, Marlena Gąsior-Głogowska, Hubert Huras, Małgorzata Komorowska
Hypertriglyceridemia, related with triglyceride (TG) in plasma above 1.7mmol/L is one of the cardiovascular risk factors. Very low density lipoproteins (VLDL) are the main TG carriers. Despite being time consuming, demanding well-qualified staff and expensive instrumentation, ultracentrifugation technique still remains the gold standard for the VLDL isolation. Therefore faster and simpler method of VLDL-TG determination is needed. Vibrational spectroscopy, including FT-IR and Raman, is widely used technique in lipid and protein research...
April 18, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28454064/withaferin-a-a-steroidal-lactone-encapsulated-mannose-decorated-liposomes-ameliorates-rheumatoid-arthritis-by-intriguing-the-macrophage-repolarization-in-adjuvant-induced-arthritic-rats
#10
Farhath Sultana, Manoj Kumar Neog, MahaboobKhan Rasool
In order to develop a better therapeutic approach for the treatment of rheumatoid arthritis (RA), withaferin-A; a steroidal lactone incorporated with mannosylated liposomes (ML-WA) was administered to adjuvant induced arthritic rats in intent to target the synovial macrophages. The confocal microscopy studies showed a successful internalization of ML-WA in the primarily isolated synovial macrophages. Consequently, targeting synovial macrophages via ML-WA reduced the oxidative stress (ROS and NO), and paw edema, however, a progressive gain in the body weight was observed in AIA rats...
April 23, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28454052/a-multi-biomarker-approach-in-scallop-chlamys-farreri-to-assess-the-impact-of-contaminants-in-qingdao-coastal-area-of-china
#11
Ruiming Guo, Luqing Pan, Rongwang Ji
A multi-biomarker approach was carried out to classify the environmental quality and the adverse effects of contaminants on scallop Chlamys farreri. The scallops were collected from three sampling stations in Qingdao coastal area of China in March, May, August and October of 2015. A suite of environmental factors and biomarkers, including temperature, salinity, pH, the concentrations of polycyclic aromatic hydrocarbons (PAHs), tetrabromobisphenol A (TBBPA) and metals (Cr, Mn, Cu, Zn, Cd, Pb, As) in seawater and soft tissue, mRNA expression of aryl hydrocarbon receptor (AhR) and P-glycoprotein (P-gp), 7-ethoxyresorufin O-deethylase (EROD), glutathione-S-transferase (GST), uridine-diphosphate-glucuronyl-transferase (UGT), sulfotransferase (SULT), metallothionein (MT), Superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), lipid peroxidation (LPO) and protein carbonyl (PC) contents and DNA strand breaks, were measured in the gill and digestive gland...
April 25, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28454029/aerosol-contributions-at-an-urban-background-site-in-eastern-mediterranean-potential-source-regions-of-pahs-in-pm10-mass
#12
Konstantinos Dimitriou, Pavlos Kassomenos
In this paper, two backward air mass trajectory-based models (Potential Source Contribution Function [PSCF] and Concentration Weighted Trajectory [CWT]) were combined, aiming to identify sources and factors defining the load of PM in the city of Limassol (Cyprus). The study also focused on the determination of atmospheric pathways enriching the aerosol phase of four carcinogenic Polycyclic Aromatic Hydrocarbons (PAHs): Benzo(a)pyrene (BaP), Benzo(a)anthracene (BaA), Benzo(b)fluoranthene (BbF) and Benzo(k)fluoranthene (BkF), in PM10 mass...
April 25, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28454027/levels-and-risk-factors-for-urinary-metabolites-of-polycyclic-aromatic-hydrocarbons-in-children-living-in-chongqing-china
#13
Shudan Liu, Qin Liu, Truls Ostbye, Mary Story, Xu Deng, Yiwen Chen, Wenyan Li, Hong Wang, Jingfu Qiu, Junfeng Zhang
AIMS: Since childhood exposure to polycyclic aromatic hydrocarbons (PAHs) have been associated with a variety of adverse health outcomes, the aims of this study were to1) document PAH exposure levels among children in Chongqing, China by measuring urinary concentrations of four PAH metabolites, 1-hydroxypyrene (1-OHPyr), 2-hydroxynaphthalene (2-OHNap), 2-hydroxyfluorine (2-OHFlu) and 9-hydroxyphenanthrene (9-OHPhe), and 2) assess the associations of urinary concentrations of these PAH metabolites with risk factors related to sources of PAHs inhalation and ingestion exposures and with personal attributes such as sex, age, and BMI...
April 24, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28453974/influences-of-dissolved-oxygen-concentration-on-biocathodic-microbial-communities-in-microbial-fuel-cells
#14
Laura Rago, Pierangela Cristiani, Federica Villa, Sarah Zecchin, Alessandra Colombo, Lucia Cavalca, Andrea Schievano
Dissolved oxygen (DO) at cathodic interface is a critical factor influencing microbial fuel cells (MFC) performance. In this work, three MFCs were operated with cathode under different DO conditions: i) air-breathing (A-MFC); ii) water-submerged (W-MFC) and iii) assisted by photosynthetic microorganisms (P-MFC). A plateau of maximum current was reached at 1.06±0.03mA, 1.48±0.06mA and 1.66±0.04mA, increasing respectively for W-MFC, P-MFC and A-MFC. Electrochemical and microbiological tools (Illumina sequencing, confocal microscopy and biofilm cryosectioning) were used to explore anodic and cathodic biofilm in each MFC type...
April 7, 2017: Bioelectrochemistry
https://www.readbyqxmd.com/read/28453972/exposure-to-ambient-pm2-5-associated-with-overall-and-domain-specific-disability-among-adults-in-six-low-and-middle-income-countries
#15
Hualiang Lin, Yanfei Guo, Yang Zheng, Xing Zhao, Zheng Cao, Steven E Rigdon, Hong Xian, Xing Li, Tao Liu, Jianpeng Xiao, Weilin Zeng, Nancy L Weaver, ZhengminMin Qian, Wenjun Ma, Fan Wu
BACKGROUND: Exposure to particulate matter pollution is associated with various cardiopulmonary diseases, which are closely related with disability. The direct relationship between air pollution and disability, however, has not been fully explored. METHODS: We used data from 45,625 participants in the Study on global AGEing and adult health in six low- and middle-income countries. The 12-item version of the World Health Organization Disability Assessment Schedule (WHODAS 2...
April 25, 2017: Environment International
https://www.readbyqxmd.com/read/28453902/lighting-up-kinase-action-in-platelets
#16
Albert Smolenski
Platelet functions are highly regulated by signaling networks involving at least 300 protein kinases [2]. Platelets express members of the mitogen-activated protein kinase (MAPK) family including p42 ERK2 and, at lower concentrations, p44 ERK1. Both ERK isoforms are activated by agonists like von Willebrand factor, collagen, thrombin, ADP and thromboxane A2 [3-7]. ERK activation depends on MAPK kinase (MKK-1 or MEK) and involves Gq, Gi, phospholipase C and Src family kinase signaling [5, 8]. Active ERK has been shown to stimulate thromboxane A2 production [5] and to contribute to platelet aggregation [4, 9]...
April 28, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28453715/the-inequity-of-inpatient-services-in-rural-areas-and-the-new-type-rural-cooperative-medical-system-nrcms-in-china-repeated-cross-sectional-analysis
#17
Bingbing Pan, Samuel D Towne, Yuxing Chen, ZhaoKang Yuan
Objective : The main aim of the New-type Rural Cooperative Medical System (NRCMS) put into effect in 2003 was to reduce financial barriers in accessing health care services among vulnerable populations. The aim of this study was to assess the association between NRCMS and income related inequality in hospital utilization among rural inhabitants in Jiangxi Province, China. Methods : A multistage stratified random cluster sampling method was adopted to select 1838, 1879, and 1890 households as participants in 2003/2004, 2008 and 2014, respectively...
June 1, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/28453568/baicalin-inhibits-biofilm-formation-attenuates-the-quorum-sensing-controlled-virulence-and-enhances-pseudomonas-aeruginosa-clearance-in-a-mouse-peritoneal-implant-infection-model
#18
Jing Luo, Biying Dong, Ke Wang, Shuangqi Cai, Tangjuan Liu, Xiaojing Cheng, Danqing Lei, Yanling Chen, Yanan Li, Jinliang Kong, Yiqiang Chen
The quorum sensing (QS) circuit plays a role in the precise regulation of genes controlling virulence factors and biofilm formation in Pseudomonas aeruginosa. QS-controlled biofilm formation by Pseudomonas aeruginosa in clinical settings has remained controversial due to emerging drug resistance; therefore, screening diverse compounds for anti-biofilm or anti-QS activities is important. This study demonstrates the ability of sub-minimum inhibitory concentrations (sub-MICs) of baicalin, an active natural compound extracted from the traditional Chinese medicinal Scutellaria baicalensis, to inhibit the formation of Pseudomonas aeruginosa biofilms and enhance the bactericidal effects of various conventional antibiotics in vitro...
2017: PloS One
https://www.readbyqxmd.com/read/28453404/effects-of-biofilter-media-depth-and-moisture-content-on-removal-of-gases-from-a-swine-barn
#19
Tongshuai Liu, Hongmin Dong, Zhiping Zhu, Bin Shang, Fubin Yin, Wanqin Zhang, Tanlong Zhou
Media depth (MD) and moisture content (MC) are two important factors that greatly influence biofilters performance. The purpose of this study was to investigate the combined effect of MC and MD on removing ammonia (NH3), hydrogen sulfide (H2S), and nitrous oxide (N2O) from swine barns. Biofiltration performance of different MDs and MCs combination based on the mixed medium of wood chips and compost were monitored. A 3×3 factorial design was adopted, which included three levels of the two factors (MC: 45%, 55%, and 67% (wet basis); MD: 0...
April 28, 2017: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/28449090/alcohol-consumption-sinus-tachycardia-and-cardiac-arrhythmias-at-the-munich-octoberfest-results-from-the-munich-beer-related-electrocardiogram-workup-study-munichbrew
#20
Stefan Brunner, Rebecca Herbel, Cathrine Drobesch, Annette Peters, Steffen Massberg, Stefan Kääb, Moritz F Sinner
Aims: Alcohol is a risk factor for cardiac arrhythmias. Retrospective analyses suggest supraventricular arrhythmias consecutive to acute alcohol consumption, but prospective data are limited. We intended to prospectively associate acute alcohol consumption with cardiac arrhythmias. Methods and results: At the 2015 Munich Octoberfest, we enrolled 3028 voluntary participants who received a smartphone-based ECG and breath alcohol concentration (BAC) measurements. ECGs were analysed for cardiac arrhythmias (sinus tachycardia, sinus arrhythmia, premature atrial/ventricular complexes, atrial fibrillation/flutter) and respiratory sinus arrhythmia...
April 25, 2017: European Heart Journal
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