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https://www.readbyqxmd.com/read/29220813/biotransformation-and-inhibition-effects-of-hexachlorocyclohexanes-during-biogas-production-from-contaminated-biomass-characterized-by-isotope-fractionation-concepts
#1
Shujuan Lian, Marcell Nikolausz, Ivonne Nijenhuis, Athaydes Francisco Leite, Hans Hermann Richnow
Hexachlorocyclohexane (HCH) production for pesticides was banned by Stockholm Convention (2009) due to its harmful and adverse effects on the environment. Despite this measure, many areas contaminated with former HCH production-waste products still require management. As a potential solution contributing to clean-up of these sites, anaerobic digestion (AD) of pesticide-contaminated biomass to produce biogas is a promising strategy. High pesticide concentrations, however, may inhibit biogas production. Therefore, laboratory-scale batch reactors were set up to investigate biogas reactor performance in presence of HCH...
November 24, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29220800/exposure-to-traffic-related-air-pollution-and-the-composition-of-the-gut-microbiota-in-overweight-and-obese-adolescents
#2
Tanya L Alderete, Roshonda B Jones, Zhanghua Chen, Jeniffer S Kim, Rima Habre, Frederick Lurmann, Frank D Gilliland, Michael I Goran
BACKGROUND: Traffic-related air pollution (TRAP) exposure has been linked to type 2 diabetes and metabolic dysfunction in humans. Animal studies suggest that air pollutants may alter the composition of the gut microbiota, which may negatively impact metabolic health through changes in the composition and/or function of the gut microbiome. OBJECTIVES: The primary aim of this study was to determine whether elevated TRAP exposure was correlated with gut bacterial taxa in overweight and obese adolescents from the Meta-AIR (Metabolic and Asthma Incidence Research) study...
December 5, 2017: Environmental Research
https://www.readbyqxmd.com/read/29220778/quantitative-assessment-of-naegleria-fowleri-and-fecal-indicator-bacteria-in-brackish-water-of-lake-pontchartrain-louisiana
#3
Jia Xue, Frederica G Lamar, Bowen Zhang, Siyu Lin, Jennifer G Lamori, Samendra P Sherchan
Brackish water samples from Lake Pontchartrain in Louisiana were assessed for the presence of pathogenic amoeba Naegleria fowleri, which causes primary amoebic meningoencephalitis (PAM). In our study, quantitative polymerase chain reaction (qPCR) methods were used to determine N. fowleri, E. coli, and enterococci in water collected from Lake Pontchartrain. N. fowleri target sequence was detected in 35.4% (56/158) of the water samples from ten sites around the lake. Statistically significant positive correlations between N...
December 5, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29220763/concentration-and-spectroscopic-characteristics-of-dom-in-surface-runoff-and-fracture-flow-in-a-cropland-plot-of-a-loamy-soil
#4
Qingsong Xian, Penghui Li, Chen Liu, Junfang Cui, Zhuo Guan, Xiangyu Tang
Being crucial for predicting the impact of source inputs on a watershed in rainfall events, an understanding of the dynamics and characteristics of dissolved organic matter (DOM) export from the soil under particular land use types, particularly those associated with underground flows is still largely lacking. A field study was carried out using a 1500m2 slope farmland plot in the hilly area of Sichuan Basin, Southwest China. The discharge of surface runoff and fracture flow was recorded and samples were collected in four representative rainfall events...
December 5, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29220746/testing-bidirectional-relationships-between-alcohol-use-and-depressive-symptoms-what-is-the-role-of-the-serotonin-transporter-gene
#5
Roy Otten, Carmen S van der Zwaluw, Rutger C Engels
Alcohol abuse often co-exists with a major depressive disorder. In order to understand the development of this comorbidity, it is important to concentrate on the preceding process. It has been suggested that the link between alcohol use and depressive symptoms is a result of an interaction with genetic factors. The aim of this study was to longitudinally examine the effect of the 5-HTTLPR genotype on the association between depressive symptoms and alcohol use in a Dutch community sample. Following a stepwise approach, bivariate correlations, longitudinal regression analyses, and latent growth curve analyses were separately conducted for 316 males and 321 females...
August 13, 2017: Alcohol
https://www.readbyqxmd.com/read/29220744/sensitive-detection-of-pyoverdine-with-an-electrochemical-sensor-based-on-electrochemically-generated-graphene-functionalized-with-gold-nanoparticles
#6
Islem Gandouzi, Mihaela Tertis, Andreea Cernat, Amina Bakhrouf, Maria Coros, Stela Pruneanu, Cecilia Cristea
The design and development of an electrochemical sensor for the sensitive and selective determination of pyoverdine, a virulence factor secreted by Pseudomonas aeruginosa, bacteria involved in nosocomial infections is presented in this work. The presence of pyoverdine in water and body fluids samples can be directly linked to the presence of the Pseudomonas bacteria, thus being a nontoxic and low cost marker for the detection of water pollution as well as for the biological contamination of other media. The sensor was elaborated using layer-by-layer technique for the deposition of a graphene‑gold nanoparticles composite film on the graphite-based screen printed electrode, from aqueous suspension...
December 5, 2017: Bioelectrochemistry
https://www.readbyqxmd.com/read/29220720/induction-of-thymic-stromal-lymphopoietin-by-a-steroid-alkaloid-derivative-in-mouse-keratinocytes
#7
Yan Weng, Natsumi Mizuno, Jiangxu Dong, Ryosuke Segawa, Takayuki Yonezawa, Byung Yoon Cha, Je-Tae Woo, Takahiro Moriya, Masahiro Hiratsuka, Noriyasu Hirasawa
Thymic stromal lymphopoietin (TSLP) plays critical roles in inducing and exacerbating allergic diseases. Chemical compounds that induce TSLP production can enhance sensitization to antigens and exacerbate allergic inflammation. Hence, identifying such chemicals will be important to prevent an increase in allergic diseases. In the present study, we found, for the first time, that a steroid alkaloid derivative, code no. 02F04, concentration and time dependently induced mRNA expression and production of TSLP in a mouse keratinocyte cell line, PAM212...
December 5, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29220718/spatial-and-temporal-dynamics-of-pathogenic-leptospira-in-surface-waters-from-the-urban-slum-environment
#8
Arnau Casanovas-Massana, Federico Costa, Irina N Riediger, Marcelo Cunha, Daiana de Oliveira, Diogenes C Mota, Erica Sousa, Vladimir A Querino, Nivisson Nery, Mitermayer G Reis, Elsio A Wunder, Peter J Diggle, Albert I Ko
Leptospirosis has emerged as an important urban health problem as slum settlements have expanded worldwide. Yet the dynamics of the environmentally transmitted Leptospira pathogen has not been well characterized in these settings. We used a stratified dense sampling scheme to study the dynamics of Leptospira abundance in surface waters from a Brazilian urban slum community. We collected surface water samples during the dry, intermediate and rainy seasons within a seven-month period and quantified pathogenic Leptospira by quantitative PCR (qPCR)...
November 30, 2017: Water Research
https://www.readbyqxmd.com/read/29220580/the-influence-of-adiposity-and-acute-exercise-on-circulating-hepatokines-in-normal-weight-and-overweight-obese-men
#9
Jack A Sargeant, Guruprasad P Aithal, Toshinari Takamura, Hirofumi Misu, Hiroaki Takayama, Jessica A Douglas, Mark C Turner, David J Stensel, Myra A Nimmo, David R Webb, Thomas Yates, James A King
Hepatokines are liver-secreted proteins with potential to influence glucose regulation and other metabolic parameters. This study investigated differences in adiposity status on five novel hepatokines and characterised their response to acute moderate-intensity exercise in groups of normal weight and overweight/obese men. Twenty-two men were recruited into normal weight and overweight/obese groups (BMI: 18.5 to 24.9 and 25.0 to 34.9 kg∙m<sup>-2</sup>). Each completed two experimental trials, exercise and control...
December 8, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29220397/desethylamiodarone-a-metabolite-of-amiodarone-induces-apoptosis-on-t24-human-bladder-cancer-cells-via-multiple-pathways
#10
Zita Bognar, Katalin Fekete, Csenge Antus, Eniko Hocsak, Rita Bognar, Antal Tapodi, Arpad Boronkai, Nelli Farkas, Ferenc Gallyas, Balazs Sumegi, Arpad Szanto
Bladder cancer (BC) is a common malignancy of the urinary tract that has a higher frequency in men than in women. Cytostatic resistance and metastasis formation are significant risk factors in BC therapy; therefore, there is great interest in overcoming drug resistance and in initiating research for novel chemotherapeutic approaches. Here, we suggest that desethylamiodarone (DEA)-a metabolite of amiodarone-may have cytostatic potential. DEA activates the collapse of mitochondrial membrane potential (detected by JC-1 fluorescence), and induces cell death in T24 human transitional-cell bladder carcinoma cell line at physiologically achievable concentrations...
2017: PloS One
https://www.readbyqxmd.com/read/29220394/a-systematic-approach-to-evaluate-the-influence-of-environmental-conditions-on-edna-detection-success-in-aquatic-ecosystems
#11
Bernhard C Stoeckle, Sebastian Beggel, Alexander F Cerwenka, Elena Motivans, Ralph Kuehn, Juergen Geist
The use of environmental DNA (eDNA) to determine the presence and distribution of aquatic organisms has become an important tool to monitor and investigate freshwater communities. The successful application of this method in the field, however, is dependent on the effectiveness of positive DNA verification, which is influenced by site-specific environmental parameters. Factors affecting eDNA concentrations in aquatic ecosystems include flow conditions, and the presence of substances that possess DNA-binding properties or inhibitory effects...
2017: PloS One
https://www.readbyqxmd.com/read/29220362/optimized-plasma-preparation-is-essential-to-monitor-platelet-stored-molecules-in-humans
#12
Marion Mussbacher, Waltraud C Schrottmaier, Manuel Salzmann, Christine Brostjan, Johannes A Schmid, Patrick Starlinger, Alice Assinger
Platelets store a plethora of different molecules within their granules, modulating numerous pathways, not only in coagulation, but also in angiogenesis, wound healing, and inflammatory diseases. These molecules get rapidly released upon activation and therefore represent an easily accessible indirect marker for platelet activation. Accurate analysis of platelet-derived molecules in the plasma requires appropriate anticoagulation to avoid in vitro activation and subsequent degranulation of platelets, potentially causing artificially high levels and masking biologically relevant differences within translational research studies...
2017: PloS One
https://www.readbyqxmd.com/read/29218605/oxymatrine-sensitizes-the-hacat-cells-to-the-ifn-%C3%AE-pathway-and-downregulates-mdc-icam-1-and-socs1-by-activating-p38-jnk-and-akt
#13
Chun-Jie Gao, Pei-Jun Ding, Li-Li Yang, Xu-Feng He, Meng-Jiao Chen, Dong-Ming Wang, Yan-Xin Tian, Hui-Min Zhang
Decreased interferon (IFN)-γ levels and increased levels of macrophage-derived chemokine (MDC) and intercellular adhesion molecule (ICAM)-1 are known to be involved in allergic skin diseases, such as eczema and atopic dermatitis. Activation of the IFN-γ and its downstream interleukin-12 (IL-12) pathway can correct these diseases. Suppressor of cytokine signaling 1 (SOCS1) is a cytokine signaling inhibitor that blocks downstream pathways of IFN-γ by blocking the mitogen-activated protein kinase (MAPK) and protein kinase B (Akt) signaling pathways...
December 7, 2017: Inflammation
https://www.readbyqxmd.com/read/29218575/flow-evaluation-of-the-leaching-hazardous-materials-from-spent-nickel-cadmium-batteries-discarded-in-different-water-surroundings
#14
Xingmei Guo, Yan Song, Junmin Nan
The leaching characteristics of hazardous materials from Ni-Cd batteries immersed in four typical water samples, i.e., water with NaCl, river water, tap water, and deionized water, were investigated to evaluate the potential environmental harm of spent Ni-Cd batteries in the water surroundings. It is shown that four water surroundings all could leach hazardous materials from the Ni-Cd batteries. The water with NaCl concentration of 66.7 mg L-1 had the highest leaching ability, the hazardous materials were leached after only approximately 50 days (average time, with a standard deviation of 4...
December 7, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29218443/prevalence-and-associated-risk-factors-of-giardia-duodenalis-infection-among-school-going-children-in-nepal
#15
Sarmila Tandukar, Jeevan B Sherchand, Jia Xue, Sital Uprety, Samendra P Sherchan, Dinesh Bhandari, Bikash Malla, Rajani Ghaju Shrestha, Laxmi Parajuli, Shristi Poudel, Ashmita Dhital, Eiji Haramoto
This study aimed to determine the prevalence of intestinal parasites and its associated risk factors among school-going children in Kathmandu, Nepal. Between August and September 2016, a total of 333 stool samples were collected from children at five public schools. The collected samples were subjected to formol-ether concentration, followed by conventional microscopic examination for intestinal parasites. The overall prevalence of intestinal parasites was 24.3% (81/333), with Giardia spp. showing the highest prevalence of 18...
December 7, 2017: Parasitology Research
https://www.readbyqxmd.com/read/29218425/ionized-and-total-serum-magnesium-in-hemodialysis-predictors-and-variability-a-longitudinal-cross-sectional-study
#16
Rosaria Del Giorno, Hilary Riva, Gaetano Donato, Luca Gabutti
BACKGROUND: Ionized Magnesium (ion-Mg) represents the active biological fraction of the serum magnesium content. The assessment of total serum Mg (tot-Mg) might not accurately identify patients with hypo-or hyper-magnesaemie. In hemodialysis, serum tot-Mg levels in the upper part of the distribution, have been associated with reduced mortality and fewer vascular calcifications; thus, resulting in the tendency to increase the Mg concentration in the dialysate, traditionally set at 0.5 mmol/L...
December 7, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29218091/angiogenic-and-wound-healing-potency-of-fermented-virgin-coconut-oil-in-vitro-and-in-vivo-studies
#17
Ahmad H Ibrahim, Haibo Li, Sawsan S Al-Rawi, Aman Shah Abdul Majid, Omar Am Al-Habib, Xiaobo Xia, Amin Ms Abdul Majid, Dan Ji
OBJECTIVE: The process of wound healing involves activation of keratinocytes, fibroblasts, endothelial cells, etc. Angiogenesis is crucial during the process of wound healing. Virgin coconut oil is widely utilized in South Asia for various purposes including food, medicinal and industrial applications. This study aimed to evaluate the potency of fermented virgin coconut oil (FVCO) in angiogenesis and wound healing via both in vitro and in vivo assays. METHODS: Human umbilical vein endothelial (HUVEC), fibroblast (CCD-18) and retinal ganglion (RGC-5) cells were cultured in medium containing different concentrations of FVCO...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29218089/the-role-of-sildenafil-in-the-development-of-transplant-arteriosclerosis-in-rat-aortic-grafts
#18
Shuai Luo, Mei Yang, Hao Jin, Zi-Qiang Xu, Yi-Fu Li, Peng Xia, Yi-Rrong Yang, Bi-Cheng Chen, Yan Zhang
Chronic rejection (CR), which is characterized histologically by progressive graft arteriosclerosis, remains a significant barrier to the long-term survival of a graft. Sildenafil has been shown to protect vascular endothelial cells. In this study, we found that sildenafil significantly reduces the thickness of transplant vascular intima in a rat aortic transplant model. Moreover, sildenafil dramatically decreased the expression of transforming growth factor-β1 (TGF-β1), vascular endothelial growth factor (VEGF), and α-smooth muscle actin (α-SMA) in the grafted aortas and increased the concentrations of cyclic guanosine monophosphate (cGMP) and endothelial nitric oxide synthase (eNOS) in serum...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29218013/lung-oxidative-stress-dna-damage-apoptosis-and-fibrosis-in-adenine-induced-chronic-kidney-disease-in-mice
#19
Abderrahim Nemmar, Turan Karaca, Sumaya Beegam, Priya Yuvaraju, Javed Yasin, Badreldin H Ali
It is well-established that there is a crosstalk between the lung and the kidney, and several studies have reported association between chronic kidney disease (CKD) and pulmonary pathophysiological changes. Experimentally, CKD can be caused in mice by dietary intake of adenine. Nevertheless, the consequence of such intervention on the lung received only scant attention. Here, we assessed the pulmonary effects of adenine (0.2% w/w in feed for 4 weeks)-induced CKD in mice by assessing various physiological histological and biochemical endpoints...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29217995/the-alteration-of-irisin-brain-derived-neurotrophic-factor-axis-parallels-severity-of-distress-disorder-in-bronchial-asthma-patients
#20
Magdolna E Szilasi, Krisztian Pak, Laszlo Kardos, Viktoria E Varga, Ildiko Seres, Angela Mikaczo, Andrea Fodor, Maria Szilasi, Gabor Tajti, Csaba Papp, Rudolf Gesztelyi, Judit Zsuga
Distress disorder (a collective term for generalized anxiety disorder and major depressive disorder) is a well-known co-morbidity of bronchial asthma. The irisin-brain-derived neurotrophic factor (BDNF) axis is a pathway that influences several neurobehavioral mechanisms involved in the pathogenesis of distress disorder. Thus, the aim of the present study was to quantify the serum irisin and BDNF concentrations in order to investigate the possible link between the irisin/BDNF axis and distress disorder in an asthma patient cohort...
2017: Frontiers in Neuroscience
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