Mone Zaidi, Se-Min Kim, Mehr Mathew, Funda Korkmaz, Farhath Sultana, Sari Miyashita, Anisa Azatovna Gumerova, Tal Frolinger, Ofer Moldavski, Orly Barak, Anusha Pallapati, Satish Rojekar, John Caminis, Yelena Ginzburg, Vitaly Ryu, Terry F Davies, Daria Lizneva, Clifford J Rosen, Tony Yuen
The past decade has seen significant advances in our understanding of skeletal homeostasis and the mechanisms that mediate the loss of bone integrity in disease. Recent breakthroughs have arisen mainly from identifying disease-causing mutations and modeling human bone disease in rodents, in essence, highlighting the integrative nature of skeletal physiology. It has become increasingly clear that bone cells, osteoblasts, osteoclasts, and osteocytes, communicate and regulate the fate of each other through RANK/RANKL/OPG, liver X receptors (LXRs), EphirinB2-EphB4 signaling, sphingolipids, and other membrane-associated proteins, such as semaphorins...
January 19, 2023: ELife