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https://www.readbyqxmd.com/read/28634477/metabolomic-analysis-and-mode-of-action-of-metabolites-of-tea-tree-oil-involved-in-the-suppression-of-botrytis-cinerea
#1
Jiayu Xu, Xingfeng Shao, Yonghua Li, Yingying Wei, Feng Xu, Hongfei Wang
Tea tree oil (TTO), a volatile essential oil, has been widely used as an antimicrobial agent. However, the mechanism underlying TTO antifungal activity is not fully understood. In this study, a comprehensive metabolomics survey was undertaken to identify changes in metabolite production in Botrytis cinerea cells treated with TTO. Significant differences in 91 metabolites were observed, including 8 upregulated and 83 downregulated metabolites in TTO-treated cells. The results indicate that TTO inhibits primary metabolic pathways through the suppression of the tricarboxylic acid (TCA) cycle and fatty acid metabolism...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28630399/dietary-mastic-oil-extracted-from-pistacia-lentiscus-var-chia-suppresses-tumor-growth-in-experimental-colon-cancer-models
#2
Katerina Spyridopoulou, Angeliki Tiptiri-Kourpeti, Evangeli Lampri, Eleni Fitsiou, Stavros Vasileiadis, Manolis Vamvakias, Haido Bardouki, Anna Goussia, Vasiliki Malamou-Mitsi, Mihalis I Panayiotidis, Alex Galanis, Aglaia Pappa, Katerina Chlichlia
Plant-derived bioactive compounds attract considerable interest as potential chemopreventive anticancer agents. We analyzed the volatile dietary phytochemicals (terpenes) present in mastic oil extracted from the resin of Pistacia lentiscus var. chia and comparatively investigated their effects on colon carcinoma proliferation, a) in vitro against colon cancer cell lines and b) in vivo on tumor growth in mice following oral administration. Mastic oil inhibited - more effectively than its major constituents- proliferation of colon cancer cells in vitro, attenuated migration and downregulated transcriptional expression of survivin (BIRC5a)...
June 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28623471/the-effect-of-intravenous-lidocaine-infusion-on-bispectral-index-during-major-abdominal-surgery
#3
Patrick Bazin, James Padley, Matthew Ho, Jennifer Stevens, Erez Ben-Menachem
Intraoperative lidocaine infusion has become widely accepted as an adjunct to general anesthesia where its use has been associated with opioid-sparing and enhanced recovery. The aims of this study were to determine whether or not intravenous (IV) lidocaine infusion (a) has an anesthetic sparing effect during major colorectal procedures and (b) if it also affects level of hypnosis as measured by bispectral index (BIS). Twenty-five patients undergoing laparotomy for resection of colorectal tumours were randomized to receive either IV lidocaine (1...
June 16, 2017: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/28612677/an-unusual-complication-with-the-administration-of-a-volatile-anesthetic-agent-for-status-asthmaticus-in-the-pediatric-intensive-care-unit-case-report-and-review-of-the-literature
#4
Brittany Shutes, W Joshua Frazier, Joseph D Tobias
In severe cases of status asthmaticus, when conventional therapies fail, volatile anesthetic agents remain a therapeutic option. When delivered outside of the operating room setting, specialized delivery techniques are needed to ensure the safe and effective use of volatile anesthetic agents. We present a 16-year-old adolescent with status asthmaticus who required the therapeutic administration of the volatile anesthetic agent, sevoflurane, in the pediatric intensive care unit (PICU). Although initially effective in reducing bronchospasm, progressive hypercarbia developed due to defective functioning of the carbon dioxide absorber of the anesthesia machine...
July 2017: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/28609175/center-for-the-polyurethanes-industry-summary-of-unpublished-industrial-hygiene-studies-related-to-the-evaluation-of-emissions-of-spray-polyurethane-foam-insulation
#5
Richard D Wood
Spray polyurethane foam (SPF) insulation is used as thermal insulation for residential and commercial buildings. It has many advantages over other forms insulation; however, concerns have been raised related to chemical emissions during and after application. The American Chemistry Council's (ACC's) Center for the Polyurethanes Industry (CPI) has gathered previously unpublished industrial hygiene air sampling studies submitted by member companies that were completed during an eight year period from 2007 to 2014...
June 13, 2017: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/28604783/chemical-structures-and-characteristics-of-animal-manures-and-composts-during-composting-and-assessment-of-maturity-indices
#6
Jieying Huang, Zixuan Yu, Hongjian Gao, Xiaoming Yan, Jiang Chang, Chengming Wang, Jingwei Hu, Ligan Zhang
Changes in physicochemical characteristics, chemical structures and maturity of swine, cattle and chicken manures and composts during 70-day composting without addition of bulking agents were investigated. Physicochemical characteristics were measured by routine analyses and chemical structures by solid-state 13C NMR and FT-IR. Three manures were of distinct properties. Their changes in physicochemical characteristics, chemical structures, and maturity were different not only from each other but also from those with addition of bulking agents during composting...
2017: PloS One
https://www.readbyqxmd.com/read/28603605/phase-behavior-of-mixed-lipid-monolayers-on-perfluorocarbon-nanoemulsions-and-its-effect-on-acoustic-contrast
#7
Rajarshi Chattaraj, Galen M Goldscheitter, Adem Yildirim, Andrew P Goodwin
Lipid-stabilized nanoemulsions containing a volatile liquid perfluorocarbon core have been studied as ultrasound contrast agents owing to their ability to transform into high-contrast microbubbles when subjected to high intensity focused ultrasound (HIFU). However, while there have been several studies on the effect of acoustic parameters on contrast, the effect of the droplet's stabilizing shell has not been studied as extensively. Inspired by previous studies showing lateral phase separation in microbubbles and vesicles, nanodroplets were formulated with a perfluorohexane core and a shell composed of varying amounts of saturated (DPPC) phospholipids, unsaturated (DOPC) phospholipids, and cholesterol, which were fractionated to obtain nanodroplets of mean diameter 300-400 nm and were stable over one week...
December 4, 2016: RSC Advances
https://www.readbyqxmd.com/read/28603137/review-nigella-sativa-prophetic-medicine-a-review
#8
Hira Ijaz, Ume Ruqia Tulain, Junaid Qureshi, Zeeshan Danish, Samina Musayab, Muhammad Furqan Akhtar, Ammara Saleem, Khanzada Khanzada Khan, Muhammad Zaman, Imran Waheed, Imran Khan, Mohamed Abdel-Daim
The present report is a significant effort to explore detail description of N. Sativa, its pharmacognostic characteristics, morphological characteristics, and mechanism of actions, doses and medicinal uses. Nigella sativa (N. Sativa) is greatest form of healing medicine. It is also known as Prophetic Medicine as its use has been mentioned in Prophetic Hadit, as natural remedy for all the diseases except death. It is recommended on daily basis in Tibb-e-Nabwi (Prophetic Medicine). Hazrat Abu Hurairah States ''I have heard from Rasool Allah (PBUH) that there is cure for every disease in black seeds except death and black seeds are shooneeze''...
January 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28595486/special-considerations-for-the-diagnosis-and-treatment-of-invasive-pulmonary-aspergillosis
#9
Matthew William McCarthy, Thomas J Walsh
The diagnosis and treatment of invasive pulmonary aspergillosis (IPA) are ongoing challenges in clinical practice. While important advances have recently been made, including enhanced diagnostic modalities as well as novel therapeutic and prophylactic options, more effective options are urgently needed as the population of immunocompromised patients continues to expand. Areas covered: In this paper, we review novel approaches to diagnosis of IPA, including multiplex PCR, Matrix Assisted Laser Desorption/Ionization-Time of Flight Mass Spectrometry and provide a detailed review of the extended-spectrum triazole isavuconazole, which was approved in 2015 to treat IPA...
June 21, 2017: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/28580087/successful-early-application-of-extracorporeal-membrane-oxygenation-to-support-cardiopulmonary-resuscitation-for-a-patient-suffering-from-severe-malignant-hyperthermia-and-cardiac-arrest-a-case-report
#10
Hyub Huh, Jae Seung Jung, Sang Jae Park, Min Kyung Park, Choon Hak Lim, Seung Zhoo Yoon
Malignant hyperthermia (MH) may lead to metabolic crisis of skeletal muscle in susceptible individuals following exposure to triggering agents such as volatile anesthetics or depolarizing muscle relaxants. MH is a rare and a potentially lethal disease, which can lead to cardiac arrest. We report a case of severe MH, in which the rapidly evolving signs of hypermetabolism eventually resulted in cardiac arrest. Despite conventional treatments following cardiopulmonary resuscitation, the patient's vital signs did not improve...
June 2017: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/28573815/tape-lift-sampling-of-chemical-threat-agents
#11
Krista Brady, Becky Stilley, Maria Olds, Terry O'Neill, James Egan, Evan Durnal
Commercial-off-the-shelf (COTS) materials were evaluated as surface samplers for the Department of Homeland Security Chemical Forensics Program. The program helps evidence collectors identify trace chemical residues at incident scenes. COTS items are widely available, produced in large lots, and with strict controls. Chemical attribution signatures were collected from common surfaces. Eight tape lift candidates were considered, five were chosen based on performance and tested for analytical interferences and extraction efficiencies with 14 chemicals...
June 2, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28567612/uncontrolled-delivery-of-liquid-volatile-anaesthetic-when-using-the-anaesthetic-conserving-device
#12
Igor Karnjuš, Dušan Mekiš, Miljenko Križmarić
During patient sedation with liquid volatile anaesthetic, some problems may occur through a process called auto-pumping, defined as an expansion of bubbles inside the syringe, which can lead to uncontrolled anaesthetic delivery. The study examined how the temperature of liquid volatile anaesthetics (sevoflurane and isoflurane) and the presence of gas bubbles in the syringe affect the occurrence of auto-pumping when using the anaesthetic conserving device (ACD, AnaConDa™, Sedana Medical, Uppsala, Sweden). Four different circumstances for each volatile anaesthetic were tested with a bench study: volatile anaesthetic at room temperature or precooled with and without the presence of gas bubbles in the syringe...
May 31, 2017: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/28562386/neurotoxicity-of-anesthetic-drugs-an-update
#13
Federico Bilotta, Lis A Evered, Shaun E Gruenbaum
PURPOSE OF REVIEW: This article reviews the most recently published evidence that investigated anesthesia-induced neurotoxicity in both animals and humans, especially as it pertains to the perinatal period. RECENT FINDINGS: Several recent studies have focused on better understanding the complex mechanisms that underlie intravenous and volatile anesthesia-induced neurotoxicity in animals. Adjuvant agents that target these pathways have been investigated for their effectiveness in attenuating the neuroapoptosis and neurocognitive deficits that result from anesthesia exposure, including dexmedetomidine, rutin, vitamin C, tumor necrosis factor α, lithium, apocynin, carreic acid phenethyl ester...
May 27, 2017: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/28559466/inhaled-drug-therapy-2016-the-year-in-review
#14
Rajiv Dhand
Some recent salient publications related to inhaled drug therapy are discussed. Unexpectedly, a 2.5-μg once-daily dose of tiotropium (Respimat) had greater efficacy than the 5.0-μg daily dose. Occurrence of a reverse dose response serves to caution us that administering more drug is not always beneficial. Small-airway inflammation contributes to pathogenesis of asthma, especially severe asthma. However, there is no conclusive evidence that the use of small-particle aerosols to target small airways improves clinical outcomes in controlled clinical trials...
May 30, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28551209/electromagnetic-induction-of-foam-based-nanoscale-zerovalent-iron-nzvi-particles-to-thermally-enhance-non-aqueous-phase-liquid-napl-volatilization-in-unsaturated-porous-media-proof-of-concept
#15
Supawan Srirattana, Kitsanateen Piaowan, Gregory V Lowry, Tanapon Phenrat
Nanoscale zerovalent iron (NZVI) is a promising remediation agent for volatile organic compound (VOC) contamination in saturated sub-surfaces, but is rarely applied to the vadose zone as there are not enough water molecules in the unsaturated zone to participate in reductive dechlorination. In this study, we evaluated the possibility of using foam as a carrying vehicle to emplace NZVI in unsaturated porous media followed by the application of low frequency-electromagnetic field (LF-EMF) to enhance VOC volatilization in laboratory batch reactors...
May 20, 2017: Chemosphere
https://www.readbyqxmd.com/read/28546948/liquigroud-technique-a-new-concept-for-enhancing-dissolution-rate-of-glibenclamide-by-combination-of-liquisolid-and-co-grinding-technologies
#16
Leila Azharshekoufeh, Javad Shokri, Mohammad Barzegar-Jalali, Yousef Javadzadeh
Introduction: The potential of combining liquisolid and co-grinding technologies (liquiground technique) was investigated to improve the dissolution rate of a water-insoluble agent (glibenclamide) with formulation-dependent bioavailability. Methods: To this end, different formulations of liquisolid tablets with a wide variety of non-volatile solvents contained varied ratios of drug: solvent and dissimilar carriers were prepared, and then their release profiles were evaluated. Furthermore, the effect of size reduction by ball milling on the dissolution behavior of glibenclamide from liquisolid tablets was investigated...
2017: BioImpacts: BI
https://www.readbyqxmd.com/read/28535600/new-approach-to-resolve-the-humidity-problem-in-voc-determination-in-outdoor-air-samples-using-solid-adsorbent-tubes-followed-by-td-gc-ms
#17
Alba Maceira, Laura Vallecillos, Francesc Borrull, Rosa Maria Marcé
This study describes the humidity effect in the sampling process by adsorbent tubes followed by thermal desorption and gas chromatography-mass spectrometry (TD-GC-MS) for the determination of volatile organic compounds (VOCs) in air samples and evaluates possible solutions to this problem. Two multi-sorbent bed tubes, Tenax TA/Carbograph 1TD and Carbotrap B/Carbopack X/Carboxen 569, were tested in order to evaluate their behaviour in the presence of environmental humidity. Humidity problems were demonstrated with carbon-based tubes, while Tenax-based tubes did not display any influence...
December 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28528539/volatile-agents-in-critical-care-sedation-yes-no-or-maybe
#18
Valerie Page, Mike Carraretto
No abstract text is available yet for this article.
May 19, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28511111/adaptive-conditions-and-safety-of-the-application-of-penicillium-frequentans-as-a-biocontrol-agent-on-stone-fruit
#19
Belén Guijarro, Inmaculada Larena, Paloma Melgarejo, Antonieta De Cal
Penicillium frequentans (Pf909) reduces brown rot caused by Monilinia spp. in stone fruit. The registration of a microbial biocontrol agent in Europe requires information on the risks and safety of a biological product. This study focused on the impact of the physical environment on Pf909 survival and growth, Pf909 mycotoxin production on fruit surface, and the Pf909 resistance to commercial antifungal compounds used in animal and human medicine. The effect of temperature (4 to 37°C), water activity (0.999 to 0...
May 8, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28507898/optically-and-acoustically-triggerable-sub-micron-phase-change-contrast-agents-for-enhanced-photoacoustic-and-ultrasound-imaging
#20
Shengtao Lin, Anant Shah, Javier Hernández-Gil, Antonio Stanziola, Bethany I Harriss, Terry O Matsunaga, Nicholas Long, Jeffrey Bamber, Meng-Xing Tang
We demonstrate a versatile phase-change sub-micron contrast agent providing three modes of contrast enhancement: 1) photoacoustic imaging contrast, 2) ultrasound contrast with optical activation, and 3) ultrasound contrast with acoustic activation. This agent, which we name 'Cy-droplet', has the following novel features. It comprises a highly volatile perfluorocarbon for easy versatile activation, and a near-infrared optically absorbing dye chosen to absorb light at a wavelength with good tissue penetration...
June 2017: Photoacoustics
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