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https://www.readbyqxmd.com/read/29775948/novel-3-phenylcoumarin-lipoic-acid-conjugates-as-multi-functional-agents-for-potential-treatment-of-alzheimer-s-disease
#1
Leili Jalili-Baleh, Hamid Nadri, Hamid Forootanfar, Alireza Samzadeh-Kermani, Tuba Tüylü Küçükkılınç, Beyza Ayazgok, Mahban Rahimifard, Maryam Baeeri, Mohsen Doostmohammadi, Loghman Firoozpour, Syed Nasir Abbas Bukhari, Mohammad Abdollahi, Mohammad Reza Ganjali, Saeed Emami, Mehdi Khoobi, Alireza Foroumadi
New series of triazole-containing 3-phenylcoumarin-lipoic acid conjugates were designed as multi-functional agents for treatment of Alzheimer's disease. The target compounds 4a-o were synthesized via the azide-alkyne cycloaddition reaction and their biological activities were primarily evaluated in terms of neuroprotection against H2 O2 -induced cell death in PC12 cells and AChE/BuChE inhibition. The promising compounds 4j and 4i containing four carbons spacer were selected for further biological evaluations...
May 2, 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29774647/effect-of-the-fetal-movement-count-on-maternal-fetal-attachment
#2
Esra Güney, Tuba Uçar
AIM: This study aimed to determine the effect of fetal movement counting on maternal-fetal attachment. METHODS: This study was a randomized controlled trial, conducted with experimental and control groups, each including 55 pregnant women from six family health centers in the Malatya Province, located in the east of Turkey. The data were collected by using a Personal Information Form and the Maternal Antenatal Attachment Scale. Training for fetal movement counting was provided to the experimental group...
May 17, 2018: Japan Journal of Nursing Science: JJNS
https://www.readbyqxmd.com/read/29763808/design-synthesis-and-evaluation-of-novel-multi-target-directed-ligands-for-treatment-of-alzheimer-s-disease-based-on-coumarin-and-lipoic-acid-scaffolds
#3
Leili Jalili-Baleh, Hamid Forootanfar, Tuba Tüylü Küçükkılınç, Hamid Nadri, Zahra Abdolahi, Alieh Ameri, Mandana Jafari, Beyza Ayazgok, Maryam Baeeri, Mahban Rahimifard, Syed Nasir Abbas Bukhari, Mohammad Abdollahi, Mohammad Reza Ganjali, Saeed Emami, Mehdi Khoobi, Alireza Foroumadi
A novel series of coumarin-lipoic acid conjugates were synthesized via cycloaddition click reaction to find out new multi-target-directed ligands (MTDLs) for treatment of Alzheimer's disease (AD). All of synthesized compounds were screened for neuroprotective and anti-cholinesterase activities. Based on primary screening, two compounds (5 and 11) were subjected to further biological evaluations. In particular, compound 11 which was the most potent AChE inhibitor showed good inhibitory effect on Aβ-aggregation and intracellular ROS (reactive oxygen species) formation, as well as the ability of selective bio-metal chelation and neuroprotection against H2 O2 - and Aβ1-42 -induced cytotoxicity...
May 2, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29755019/the-importance-of-acoustic-radiation-force-impulse-arfi-elastography-in-the-diagnosis-and-clinical-course-of-acute-pancreatitis
#4
Muhsin Kaya, Serdar Değirmenci, Cemil Göya, Elif Tuba Tuncel, Feyzullah Uçmak, Mehmet Ali Kaplan
BACKGROUND/AIMS: Acute pancreatitis (AP) is characterized by acute inflammation of the pancreas and it has a highly variable clinical course. The aim of our study was to evaluate the value of acoustic radiation force impulse (ARFI) elastography in the diagnosis and clinical course of AP. MATERIALS AND METHODS: Consecutive patients with a diagnosis of AP (patients group) and healthy subject (control group) were prospectively enrolled to the study. Demographic features and clinical, laboratory, and radiological data were recorded...
May 2018: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/29744787/ada-deficiency-evaluation-of-the-clinical-and-laboratory-features-and-the-outcome
#5
Deniz Cagdas, Pınar Gur Cetinkaya, Betül Karaatmaca, Saliha Esenboga, Cagman Tan, Togay Yılmaz, Ersin Gümüş, Safa Barış, Barış Kuşkonmaz, Tuba Turul Ozgur, Pawan Bali, Ines Santisteban, Diclehan Orhan, Aysel Yüce, Duygu Cetinkaya, Kaan Boztug, Michael Hershfield, Ozden Sanal, İlhan Tezcan
INTRODUCTION: Adenosine deaminase (ADA) deficiency is an autosomal recessive primary immunodeficiency. It results in the intracellular accumulation of toxic metabolites which have effects particularly on lymphocytes and the brain. The aim of this study was to evaluate the outcome of 13 ADA-deficient patients. We planned to evaluate their clinical and laboratory findings before and after enzyme replacement therapy (ERT), allogeneic hematopoietic stem cell transplantation (aHSCT), and hematopoietic stem cell gene therapy (HSCGT)...
May 9, 2018: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/29741962/the-multiple-sclerosis-work-difficulties-questionnaire-translation-and-cross-cultural-adaptation-to-turkish-and-assessment-of-validity-and-reliability
#6
Turhan Kahraman, Asiye Tuba Özdoğar, Cynthia Alison Honan, Özge Ertekin, Serkan Özakbaş
PURPOSE: To linguistically and culturally adapt the Multiple Sclerosis Work Difficulties Questionnaire-23 (MSWDQ-23) for use in Turkey, and to examine its reliability and validity. METHODS: Following standard forward-back translation of the MSWDQ-23, it was administered to 124 people with multiple sclerosis (MS). Validity was evaluated using related outcome measures including those related to employment status and expectations, disability level, fatigue, walking, and quality of life...
May 9, 2018: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29739920/a-rare-case-of-complete-esophageal-obstruction-following-esophageal-variceal-band-ligation-evbl-for-esophageal-varices-performed-by-esophagogastroduodenoscopy-egd
#7
Muhammad Aziz, Beth Floyd, Tuba Esfandyari
BACKGROUND Esophageal variceal band ligation (EVBL) performed by esophagogastroduodenoscopy (EGD) is a routinely performed procedure for the treatment of esophageal varices that is undertaken to control bleeding and prevent further complications. This report is of a case of a rare complication of complete esophageal obstruction following EVBL. CASE REPORT A 69-year-old woman underwent EVBL for esophageal varices. She subsequently presented with complete obstruction of the esophageal lumen with ulceration, which was seen on repeat EGD...
May 9, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29724423/acr-appropriateness-criteria-%C3%A2-abdominal-aortic-aneurysm-interventional-planning-and-follow-up
#8
Christopher J Francois, Erik P Skulborstad, Bill S Majdalany, Ankur Chandra, Jeremy D Collins, Khashayar Farsad, Marie D Gerhard-Herman, Heather L Gornik, A Tuba Kendi, Minhajuddin S Khaja, Margaret H Lee, Patrick D Sutphin, Baljendra S Kapoor, Sanjeeva P Kalva
Abdominal aortic aneurysms (AAAs) are a relatively common vascular problem that can be treated with either open, surgical repair or endovascular aortic aneurysm repair (EVAR). Both approaches to AAA repair require dedicated preoperative imaging to minimize adverse outcomes. After EVAR, cross-sectional imaging has an integral role in confirming the successful treatment of the AAA and early detection of complications related to EVAR. CT angiography is the primary imaging modality for both preoperative planning and follow-up after repair...
May 2018: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29724414/acr-appropriateness-criteria-%C3%A2-lower-extremity-arterial-revascularization-post-therapy-imaging
#9
Kyle Cooper, Bill S Majdalany, Sanjeeva P Kalva, Ankur Chandra, Jeremy D Collins, Christopher J Francois, Suvranu Ganguli, Heather L Gornik, A Tuba Kendi, Minhajuddin S Khaja, Jeet Minocha, Patrick T Norton, Piotr Obara, Stephen P Reis, Patrick D Sutphin, Frank J Rybicki
Peripheral arterial disease (PAD) affects millions across the world and in the United States between 9% to 23% of all patients older than 55 years. The refinement of surgical techniques and evolution of endovascular approaches have improved the success rates of revascularization in patients afflicted by lower extremity PAD. However, restenosis or occlusion of previously treated vessels remains a pervasive issue in the postoperative setting. A variety of different imaging options are available to evaluate patients and are reviewed within the context of asymptomatic and symptomatic patients with PAD who have previously undergone endovascular or surgical revascularization...
May 2018: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29723395/the-scale-for-body-image-concerns-during-pregnancy-development-and-validation
#10
Tuba Uçar, Esra Güney, Büşra Cesur, Zeliha Burcu Yurtsal
PURPOSE: This study aimed to develop a scale that measures body image concerns during pregnancy. DESIGN AND METHODS: The study administered draft of the scale for validity and reliability analysis to 320 pregnant women who visited the maternity polyclinic of a public hospital in eastern Turkey between February and May 2016. FINDINGS: The Cronbach's alpha reliability coefficient of the entire scale was 0.88. Factor analysis determined that the 23 items that explained 58...
May 3, 2018: Perspectives in Psychiatric Care
https://www.readbyqxmd.com/read/29714452/increased-micronucleus-count-predicts-malignant-behavior-in-pleural-effusion-fluid
#11
Tuba Dilay Kökenek Ünal, İpek Çoban
Background/aim: Micronucleus (MN) frequency is used as a biomarker of chromosomal damage, genome instability, and cancer risk. The aim of this study was to evaluate the diagnostic usefulness of MN frequency to differentiate between malignant and benign pleural effusion samples. Materials and methods: Retrospectively, 78 pleural fluid cytology samples (including 20 cases of benign reactive mesothelial cells, 22 cases of suspicious cytology, and 36 cases of malignant cytology) were examined. The number of micronucleated cells in 1000 well- preserved cells was counted...
April 30, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29708441/in-situ-blood-coagulum-versus-sutures-for-autograft-fixation-after-pterygium-excision
#12
Tuba Celik
PURPOSE: To compare the outcomes of autograft fixation using patient's own blood coagulum and using sutures after pterygium excision. METHODS: In this prospective clinical study 30 eyes of 30 patients with primary pterygium were randomly assigned into two groups: Group 1 (15 eyes) underwent autograft fixation with 10/0 nylon sutures and Group 2 (15 eyes) underwent autograft fixation by using in situ blood coagulum following pterygium excision. Primary outcome measure of this study was graft failure and displacement...
April 30, 2018: Current Eye Research
https://www.readbyqxmd.com/read/29689430/transcription-factors-wrky11-and-wrky17-are-involved-in-abiotic-stress-responses-in-arabidopsis
#13
Muhammad Amjad Ali, Farrukh Azeem, Muhammad Amjad Nawaz, Tuba Acet, Amjad Abbas, Qari Muhammad Imran, Kausar Hussain Shah, Hafiz Mamoon Rehman, Gyuhwa Chung, Seung Hwan Yang, Holger Bohlmann
Plant WRKY transcription factors play a vital role in abiotic stress tolerance and regulation of plant defense responses. This study examined AtWRKY11 and AtWRKY17 expression under ABA, salt, and osmotic stress at different developmental stages in Arabidopsis. We used reverse transcriptase PCR, quantitative real-time PCR, and promoter:GUS lines to analyze expression. Both genes were upregulated in response to abiotic stress. Next, we applied the same stressors to seedlings of T-DNA insertion wrky11 and 17 knock-out mutants (single and double)...
April 17, 2018: Journal of Plant Physiology
https://www.readbyqxmd.com/read/29679027/author-correction-circulating-haptoglobin-and-metabolic-syndrome-in-renal-transplant-recipients
#14
Isidor Minović, Michele F Eisenga, Ineke J Riphagen, Else van den Berg, Jenny Kootstra-Ros, Anne-Roos S Frenay, Harry van Goor, Gerald Rimbach, Tuba Esatbeyoglu, Andy P Levy, Carlo A J M Gaillard, Johanna M Geleijnse, Manfred L Eggersdorfer, Gerjan J Navis, Ido P Kema, Stephan J L Bakker
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
April 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29668540/aplastic-anemia-as-an-immune-mediated-complication-of-thymoma-a-case-report
#15
Ersin Toret, Bengü Demirag, Sultan A Köker, Onur Doyurgan, Malik Ergin, Sinan Genc, Tuba H Karapinar, Yilmaz Ay, Yeşim Oymak, Canan Vergin
Thymomas are the most common masses located in the anterior mediastinum, and they are often associated with autoimmune disorders including myasthenia gravis, polymyositis, and aplastic anemia (AA). Autoreactive T-cell clones generated by the thymoma may lead to autoimmune disorders. We report the case of a 14-year-old boy who was examined for AA, and the underlying cause was determined to be an immune-mediated complication of thymoma. He had no matched sibling donors. He underwent thymectomy, and 3 months later he was treated with immunosuppressive therapy (IST), consisting of antithymocyte globulin and cyclosporine A...
April 17, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29658163/a-novel-oncolytic-herpes-capable-of-cell-specific-transcriptional-targeting-of-cd133%C3%A2-cancer-cells-induces-significant-tumor-regression
#16
Kaoru Terai, Danse Bi, Zhengian Liu, Emma Borrego-Diaz, Kyle Kimura, Zohreh Sanaat, Roya Dolatkhah, Mina Soleimani, Christopher Jones, Judith Larson, Allison Bright, Tuba Esfandyari, Faris Farassati
The topic of cancer stem cells is of significant importance due to its implications in our understanding of the tumor biology, as well as the development of novel cancer therapeutics. However, the question of whether targeting cancer stem cells can hamper the growth of tumors remains mainly unanswered due to the lack of specific agents for this purpose. In order to address this issue, we have developed the first mutated version of herpes simplex virus-1 (HSV-1) that is transcriptionally targeted against CD133+ cells...
April 15, 2018: Stem Cells
https://www.readbyqxmd.com/read/29649396/surgeons-perceived-barriers-to-palliative-and-end-of-life-care-a-mixed-methods-study-of-a-surgical-society
#17
Pasithorn A Suwanabol, Ari C Reichstein, Z Tuba Suzer-Gurtekin, Jane Forman, Maria J Silveira, Lona Mody, Arden M Morris
BACKGROUND: Nearly 20% of colorectal cancer (CRC) patients present with potentially incurable (Stage IV) disease, yet their physicians do not integrate cancer treatment with palliative care. Compared with patients treated by primary providers, surgical patients with terminal diseases are significantly less likely to receive palliative or end-of-life care. OBJECTIVE: To describe surgeon perspectives on palliative and end-of-life care for patients with Stage IV CRCs...
March 13, 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29645281/the-effects-of-infertility-on-perception-of-body-in-pregnancy-a-comparative-study
#18
Yeşim Aksoy Derya, Sermin Timur Taşhan, Tuba Uçar
PURPOSE: This study aimed to determine the effects of infertility on perception of body in pregnancy. DESIGN AND METHODS: This comparative study was conducted with 428 pregnant women (in vitro fertilization [IVF = 214, spontaneously conceived/SC = 214]). FINDINGS: The IVF group had a higher body image scale (BIS) score. Moreover, it was observed that the IVF group had more positive views on growth in the abdominal area, gaining weight, and changes in skin...
April 12, 2018: Perspectives in Psychiatric Care
https://www.readbyqxmd.com/read/29625027/bi-allelic-mutations-in-klhl7-cause-a-crisponi-ciss1-like-phenotype-associated-with-early-onset-retinitis-pigmentosa
#19
Andrea Angius, Paolo Uva, Insa Buers, Manuela Oppo, Alessandro Puddu, Stefano Onano, Ivana Persico, Angela Loi, Loredana Marcia, Wolfgang Höhne, Gianmauro Cuccuru, Giorgio Fotia, Manila Deiana, Mara Marongiu, Hatice Tuba Atalay, Sibel Inan, Osama El Assy, Leo M E Smit, Ilyas Okur, Koray Boduroglu, Gülen Eda Utine, Esra Kılıç, Giuseppe Zampino, Giangiorgio Crisponi, Laura Crisponi, Frank Rutsch
No abstract text is available yet for this article.
April 5, 2018: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29621087/comparison-of-osseointegration-of-five-different-surfaced-titanium-implants
#20
Serkan Dundar, Ferhan Yaman, Alihan Bozoglan, Tuba Talo Yildirim, Mustafa Kirtay, Muhammet Fatih Ozupek, Gokhan Artas
The topography, chemical features, surface charge, and hydrophilic nature of titanium implant surfaces are crucial factors for successful osseointegration. This study aimed to investigate the bone implant contact (BIC) ratio of titanium dental implants with different surface modification techniques using the rat femoral bone model. Sandblasted and acid washed (SL-AW), sandblasted (SL), resorbable blast material (RBM), microarc (MA), and sandblasted and microarc (SL-MA) surfaces were compared in this study. Forty male Sprague-Dawley rats were used in this study...
April 4, 2018: Journal of Craniofacial Surgery
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