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https://www.readbyqxmd.com/read/28622482/antidiabetic-properties-of-an-apple-kale-extract-in-vitro-in-situ-and-in-mice-fed-a-western-type-diet
#1
Anke Schloesser, Tuba Esatbeyoglu, Gerhard Schultheiß, Henning Vollert, Kai Lüersen, Alexandra Fischer, Gerald Rimbach
Type 2 diabetes mellitus (T2DM) is a common and increasingly prevalent metabolic disorder, and effective preventive strategies against this disease are needed. The aim of the present study was to evaluate the potential antidiabetic properties of a dietary apple/kale extract (AKE), which was rich in phlorizin and flavonoids, in laboratory mice. Mice were fed a control diet, a Western-type high-sugar, high-fat diet (WTD), or a WTD plus AKE for 10 weeks. Body weight, food and energy intake, body composition, and blood glucose level were recorded in addition to the postprandial rise in blood glucose concentration after a single administration of glucose (oral glucose tolerance test, OGTT)...
June 16, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28610417/effect-of-midwifery-based-counseling-support-program-on-body-image-of-breast-cancer-women-survivors
#2
Zeinab Hamzehgardeshi, Mahmood Moosazadeh, Forouzan Elyasi, Ghasem Janbabai, Maedeh Rezaei, Zeinab Yeganeh, Masoumeh Rashidi Alashti
Background: Treatment for breast cancer can give rise to complications with important psychological impact. One change in patients regards body image. The aim of this research was to study the effect of a midwifery-based counseling support program on the body image of breast cancer survivors. Materials and Methods: In this randomized clinical trial, the study population was constituted by 80 breast cancer patients referred to Tuba Clinic in Sari, north of Iran, randomly assigned to two groups. Inclusion criteria included breast cancer diagnosis, mastectomy experience, age of 30 to 60 years, primary school education or higher, being married, and receiving hormone therapy...
May 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28607511/technique-sizing-up-tumours-with-tuba-seq
#3
Michelle Trenkmann
No abstract text is available yet for this article.
June 12, 2017: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/28598228/hdac6-inhibition-disrupts-maturational-progression-and-meiotic-apparatus-assembly-in-mouse-oocytes
#4
Li Ling, Feifei Hu, Xiaoyan Ying, Juan Ge, Qiang Wang
Histone deacetylases (HDACs) have been implicated in diverse biological processes including transcriptional regulation, signal transduction, and developmental control. However, the role of HDAC6 in mammalian oocytes remains unknown. In the present study, by employing Tubastatin A (TubA), a selective HDAC6 inhibitor, we examined the effects of HDAC6 on maturational progression and meiotic apparatus in mouse oocytes. We found that HDAC6 inhibition results in maturation arrest and disruption of spindle morphology and chromosome alignment...
June 9, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28595480/in-vitro-evaluation-of-cobalt-oxide-nanoparticle-induced-toxicity
#5
Mahmoud Abudayyak, Tuba Altincekic Gurkaynak, Gül Özhan
Cobalt oxide (Co3O4) nanoparticles have applications in nanomedicine and nanotechnology; therefore, any possible adverse effects require thorough investigation. The present study investigated the effects of Co3O4 nanoparticles on four different cell lines: liver, HepG2 hepatocellular carcinoma cells; lung, A549 lung carcinoma cells; gastrointestinal, Caco-2 colorectal adenocarcinoma cells; and nervous system, SH-SY5Y neuroblastoma cells. A difference was observed in cell sensitivity toward Co3O4 nanoparticles...
January 1, 2017: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/28572731/understanding-the-associations-between-psychosocial-factors-and-severity-of-crime-in-juvenile-delinquency-a-cross-sectional-study
#6
Sarper Taşkıran, Tuba Mutluer, Ali Evren Tufan, Bengi Semerci
PURPOSE: Juvenile delinquency is a serious and common problem. To date, several studies have focused on possible psychosocial risk factors for delinquency among youths and on the implications of childhood mental illness on child criminality. However, the literature on prevalence of psychopathology and predictors of crime severity among delinquent youths in Turkey is sparse. Therefore, the aim of this study was to show the associations between crime severity and psychosocial factors such as gender, age, criminal history, concomitant attention deficit hyperactivity disorder (ADHD) and other comorbid psychiatric conditions, along with behavioral problem domains of Child Behavior Checklist (CBCL)...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28539409/spatial-analysis-of-cdc42-activity-reveals-a-role-for-plasma-membrane-associated-cdc42-in-centrosome-regulation
#7
Kari A Herrington, Andrew L Trinh, Carolyn Dang, Ellen O'Shaughnessy, Klaus M Hahn, Enrico Gratton, Michelle A Digman, Christine Sütterlin
The ability of the small GTPase Cdc42 to regulate diverse cellular processes depends on tight spatial control of its activity. Cdc42 function is best understood at the plasma membrane (PM), where it regulates cytoskeletal organization and cell polarization. Active Cdc42 has also been detected at the Golgi, but its role and regulation at this organelle is only partially understood. Here we analyze the spatial distribution of Cdc42 activity by monitoring the dynamics of the Cdc42 FLARE biosensor using the phasor approach to FLIM-FRET...
May 24, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28534259/the-efficacy-of-orbital-ultrasonography-and-magnetic-resonance-imaging-findings-with-direct-measurement-of-intracranial-pressure-in-distinguishing-papilledema-from-pseudopapilledema
#8
Zeynep Ozturk, Tuba Atalay, Ebru Arhan, Kursad Aydin, Ayse Serdaroglu, Tugba Hirfanoglu, Cengiz Havali, Yilmaz Akbas, Duygu Yalinbas
INTRODUCTION: The goal of this study was to evaluate the utility of orbital ultrasonography and magnetic resonance imaging in the diagnosis of idiopathic intracranial hypertension (IIH). METHOD: We reviewed the medical records of patients referred to our department for suspected IIH. RESULTS: Seven children were diagnosed with IIH. Nine children revealed pseudopapilledema by optic coherence tomography and/or orbital ultrasonography. When the axial sequences were reexamined, patients with papilledema had optic nerve sheath (ONS) enlargement (6...
May 22, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28530655/a-quantitative-and-multiplexed-approach-to-uncover-the-fitness-landscape-of-tumor-suppression-in-vivo
#9
Zoë N Rogers, Christopher D McFarland, Ian P Winters, Santiago Naranjo, Chen-Hua Chuang, Dmitri Petrov, Monte M Winslow
Cancer growth is a multistage, stochastic evolutionary process. While cancer genome sequencing has been instrumental in identifying the genomic alterations that occur in human tumors, the consequences of these alterations on tumor growth remain largely unexplored. Conventional genetically engineered mouse models enable the study of tumor growth in vivo, but they are neither readily scalable nor sufficiently quantitative to unravel the magnitude and mode of action of many tumor-suppressor genes. Here, we present a method that integrates tumor barcoding with ultradeep barcode sequencing (Tuba-seq) to interrogate tumor-suppressor function in mouse models of human cancer...
May 22, 2017: Nature Methods
https://www.readbyqxmd.com/read/28515650/prevalence-and-comparing-of-some-microbiological-properties-somatic-cell-count-and-antibiotic-residue-of-organic-and-conventional-raw-milk-produced-in-turkey
#10
Bayram Ürkek, Mustafa Şengül, Tuba Erkaya, Vecihi Aksakal
The aim of this study was to investigate the effects of production systems and milk collection periods on the somatic cell count (SCC), some microbiological properties, total aerobic mesophilic bacteria (TAMB), coliform, Staphylococcus aureus (S. aureus), yeast and mould) and antibiotic residue of milk; in Turkey. Milk samples were collected from 9 conventional farms and 9 organic farms during one year time, at six different months (December 2013 to October 2014), and all farms were selected from the same geographical locations...
2017: Korean Journal for Food Science of Animal Resources
https://www.readbyqxmd.com/read/28515524/spinal-anaesthesia-for-a-caesarean-section-in-a-patient-with-paraneoplastic-cerebellar-ataxia
#11
Ayca Tas Tuna, Fatih Sahin, Dilcan Kotan, Ali Fuat Erdem, Meltem Baykara, Tuba Duzcan
Paraneoplastic cerebellar ataxia (PCA) is most frequently observed in gynaecological cancers, small cell lung cancer, breast cancer, Hodgkin's lymphoma, cancer testis or malignant thymoma. In the literature, there is no data related to the effects of PCA during pregnancy or reports on the effects of anaesthesia in patients with PCA. We present management of a pregnant woman with PCA who was suddenly unable to walk with PCA and for whom effective spinal anaesthesia was performed for an elective caesarean section with no complications...
April 2017: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/28504500/infantile-onset-thiamine-responsive-megaloblastic-anemia-syndrome-with-slc19a2-mutation-a-case-report
#12
Nagehan Katipoğlu, Tuba H Karapinar, Korean Demir, Sultan Aydin Köker, Özlem Nalbantoğlu, Yılmaz Ay, Hüseyin A Korkmaz, Yeşim Oymak, Melek Yıldız, Selma Tunç, Filiz Hazan, Canan Vergin, Behzat Ozkan
BACKGROUND: Thiamine-responsive megaloblastic anemia syndrome (TRMA), also known as Rogers syndrome, is characterized by megaloblastic anemia, sensorineural hearing loss, and diabetes mellitus. Disturbances of the thiamine transport into the cells results from homozygous or compound heterozygous mutations in the SLC19A2 gene. CASE PRESENTATION: We report a girl which presented with sensorineural deafness treated with a hearing prosthesis, insulin requiring diabetes, macrocytic anemia, treated with thiamine (100 mg/day)...
June 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28476986/biosynthesis-of-silver-nanoparticles-by-streptomyces-griseorubens-isolated-from-soil-and-their-antioxidant-activity
#13
Tuba Baygar, Aysel Ugur
Microbial mediated biological synthesis of metallic nanoparticles was carried out ecofriendly in the present study. Silver nanoparticles (AgNPs) were extracellularly biosynthesised from Streptomyces griseorubens AU2 and extensively characterised by ultraviolet-visible (UV-vis) and Fourier transform infrared spectroscopy, high-resolution transmission electron microscopy, scanning electron microscopy and X-ray diffraction analysis. Elemental analysis of nanoparticles was also carried out using energy dispersive X-ray spectroscopy...
April 2017: IET Nanobiotechnology
https://www.readbyqxmd.com/read/28473274/alterations-in-optic-nerve-sheath-diameter-according-to-cerebrovascular-disease-sub-groups
#14
Emre Gökcen, İbrahim Caltekin, Atakan Savrun, Hilal Korkmaz, Şeyda Tuba Savrun, Gökhan Yıldırım
BACKGROUND: ONSD (optic nerve sheath diameter) is a method used for indirect measurement of the increased intracranial pressure. In previous studies, the relation between the increased intracranial pressure and ONSD was analyzed in the patients suffering from cerebrovascular diseases (CVD). In our study, the patients suffering from ischemic CVD were categorized into 4 subgroups according to Oxfordshire Community Stroke Project classification (OCSP); the relationship between each group and ONSD, and the influence on each eye were analyzed...
April 30, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28473082/acr-appropriateness-criteria-%C3%A2-pulsatile-abdominal-mass-suspected-abdominal-aortic%C3%A2-aneurysm
#15
Stephen P Reis, Bill S Majdalany, Ali F AbuRahma, Jeremy D Collins, Christopher J Francois, Suvranu Ganguli, Heather L Gornik, A Tuba Kendi, Minhajuddin S Khaja, Patrick T Norton, Patrick D Sutphin, Frank J Rybicki, Sanjeeva P Kalva
Clinical palpation of a pulsating abdominal mass alerts the clinician to the presence of a possible abdominal aortic aneurysm (AAA). Imaging studies are important in diagnosing and categorizing the extent of the aneurysm and may aid in treatment planning. The consensus of the literature supports the use of ultrasound as the initial screening test in patients with suspected AAA. Population-based ultrasound screening studies have been recommended and have proved effective for male patients > 65 years of age...
May 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28473078/acr-appropriateness-criteria-%C3%A2-plexopathy
#16
Julie Bykowski, Joseph M Aulino, Kevin L Berger, R Carter Cassidy, Asim F Choudhri, A Tuba Kendi, Claudia F E Kirsch, Michael D Luttrull, Aseem Sharma, Vilaas S Shetty, Khoi Than, Christopher J Winfree, Rebecca S Cornelius
MRI without and with contrast is the most accurate imaging method to determine whether a process is intrinsic or extrinsic to a nerve of the brachial or lumbosacral plexus. However, there are no Current Procedural Terminology codes to correspond to imaging studies of the brachial or lumbar plexus discretely. This assessment uses "MRI of the brachial plexus" or "MRI of the lumbosacral plexus" as independent entities given that imaging acquisition for the respective plexus differs in sequences and planes compared with those of a routine neck, chest, spine, or pelvic MRI, yet acknowledges the potential variability of ordering practices across institutions...
May 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28471662/pyridyl-acyl-hydrazone-rotaxanes-and-molecular-shuttles
#17
David A Leigh, Vanesa Marcos, Tugrul Nalbantoglu, Iñigo J Vitorica-Yrezabal, F Tuba Yasar, Xiaokang Zhu
We report on rotaxanes featuring a pyridyl-acyl hydrazone moiety on the axle as a photo/thermal-switchable macrocycle binding site. The pyridyl-acyl E-hydrazone acts as a hydrogen bonding template that directs the assembly of a benzylic amide macrocycle around the axle to form [2]rotaxanes in up to 85% yield; the corresponding Z-hydrazone thread affords no rotaxane under similar conditions. However, the E-rotaxane can be smoothly converted into the Z-rotaxane in 98% yield under UV irradiation. The X-ray crystal structures of the E- and Z-rotaxanes show different intercomponent hydrogen bonding patterns...
May 11, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28468164/effects-of-surgical-and-nonsurgical-rapid-maxillary-expansion-on-palatal-structures
#18
Gökmen Kurt, Ayşe Tuba Altuğ, Gökhan Türker, Banu Kiliç, Erdem Kiliç, Alper Alkan
AIM: The aim of the present study was to compare the effects of surgical and nonsurgical rapid maxillary expansion (RME) in skeletally mature patients. MATERIALS AND METHODS: Surgically assisted rapid maxillary expansion (SARME) was used in 18 patients (2 males, 16 females) with a mean age of 19.90 years. Two nonsurgical RME groups were constructed to compare the expansion changes of SARME. Eighteen patients in maximum pubertal peak (12 males, 6 females) with a mean age of 13...
May 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28454701/expression-profiling-of-maternal-plasma-and-placenta-micrornas-in-preeclamptic-pregnancies-by-microarray-technology
#19
Tuba Gunel, Mohammad Kazem Hosseini, Ece Gumusoglu, Halil Ibrahim Kisakesen, Ali Benian, Kilic Aydinli
Preeclampsia (PE) is one of the leading causes of maternal and fetal morbidity and mortality, occurring usually in the second half of pregnancy and affecting approximately 5-8% of pregnancies in the world. miRNAs play critical role in the regulation of placental development processes. We aimed to determine specific novel miRNAs for early diagnosis of preeclampsia which is one of the most dangerous pregnancy diseases. In this study 72 samples, maternal age 22 ≤ and ≤36, have been analyzed; maternal plasma and placental miRNAs were isolated from 18 severe preeclampsia (sPE) patients and 18 controls, respectively...
April 2017: Placenta
https://www.readbyqxmd.com/read/28450846/perceptually-salient-regions-of-the-modulation-power-spectrum-for-musical-instrument-identification
#20
Etienne Thoret, Philippe Depalle, Stephen McAdams
The ability of a listener to recognize sound sources, and in particular musical instruments from the sounds they produce, raises the question of determining the acoustical information used to achieve such a task. It is now well known that the shapes of the temporal and spectral envelopes are crucial to the recognition of a musical instrument. More recently, Modulation Power Spectra (MPS) have been shown to be a representation that potentially explains the perception of musical instrument sounds. Nevertheless, the question of which specific regions of this representation characterize a musical instrument is still open...
2017: Frontiers in Psychology
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