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Bone scans in prostate cancer

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https://www.readbyqxmd.com/read/29137438/prognostic-value-of-bone-scan-index-as-an-imaging-biomarker-in-metastatic-prostate-cancer-a-meta-analysis
#1
Dongyang Li, Hang Lv, Xuanyu Hao, Yudi Dong, Huixu Dai, Yongsheng Song
Background: The prognostic value of the bone scan index (BSI) in metastatic prostate cancer (mPCa) remained controversial. Therefore, we performed a meta-analysis to determine the predictive value of BSI and survival in patients with mPCa. Materials and Methods: A literature search was performed in PubMed, Embase, Web of Science and Cochrane library databases. Hazard ratios (HRs), concordance indices (C-indices) were extracted to estimate the relationship between BSI and survival in patients with mPCa...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29134357/apparent-diffusion-coefficient-of-vertebral-haemangiomas-allows-differentiation-from-malignant-focal-deposits-in-whole-body-diffusion-weighted-mri
#2
Jessica M Winfield, Gabriele Poillucci, Matthew D Blackledge, David J Collins, Vallari Shah, Nina Tunariu, Martin F Kaiser, Christina Messiou
OBJECTIVES: The aim of this study was to identify apparent diffusion coefficient (ADC) values for typical haemangiomas in the spine and to compare them with active malignant focal deposits. METHODS: This was a retrospective single-institution study. Whole-body magnetic resonance imaging (MRI) scans of 106 successive patients with active multiple myeloma, metastatic prostate or breast cancer were analysed. ADC values of typical vertebral haemangiomas and malignant focal deposits were recorded...
November 13, 2017: European Radiology
https://www.readbyqxmd.com/read/29123014/positron-emission-tomography-using-a-grpr-antagonist-68-ga-rm26-in-healthy-volunteers-and-prostate-cancer-patients
#3
Jingjing Zhang, Gang Niu, Xingrong Fan, Lixin Lang, Guozhu Hou, Libo Chen, Huanwen Wu, Zhaohui Zhu, Fang Li, Xiaoyuan Chen
This study was designed to study the safety, biodistribution, radiation dosimetry of a gastrin-releasing peptide receptor (GRPR) antagonist positron emission tomography (PET) tracer (68)Ga-RM26, to assess its clinical diagnostic value in prostate cancer patients, and to perform a direct comparison between GRPR antagonist (68)Ga-RM26 and agonist (68)Ga-BBN. Methods: Five healthy volunteers were enrolled to validate the safety of (68)Ga-RM26 and calculate dosimetry. A total of 28 patients with prostate cancer (17 newly diagnosed and 11 post therapy) were recruited with written informed consent...
November 9, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29114610/initiative-to-reduce-bone-scans-for-low-risk-prostate-cancer-patients-a-quasi-experimental-before-and-after-study-in-a-veterans-affairs-hospital
#4
Eric Ojerholm, Keith N Van Arsdalen, Robert E Roses, Patrick Tripp
Purpose: Bone scans (BS) are a low-value test for asymptomatic men with low-risk prostate cancer. We performed a quality improvement intervention aimed at reducing BS for these patients. Methods and materials: The intervention was a presentation that leveraged the behavioral science concepts of social comparison and normative appeals. Participants were multidisciplinary stakeholders from the Radiation Oncology and Urology services at a Veterans Affairs hospital...
July 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29099380/-consensus-on-castration-resistant-prostate-cancer-management-in-spain
#5
Antonio Alcaraz, Luís Martínez-Piñeiro, Alfredo Rodríguez, José Rubio, Ángel Borque, Javier Burgos, Joaquín Carballido, José Manuel Cózar, Itziar Crespo, Salvador Esquena, Francisco Gómez-Veiga, Dionisio López, Bernardino Miñana, Juan Morote, María José Ribal, Eduardo Solsona, José Francisco Suárez, Miguel Unda
OBJECTIVES: To move towards a more standardized approach in clinical practice to manage patients with castration-resistant prostate cancer (CRPC) in Spain. METHODS: A panel of 18 Spanish experts in Urology with expertise managing CRPC followed a modified Delphi process with two rounds and a final face-to-face consensus meeting. The panel considered a total of 106 clinical questions divided into the following 6 sections: definition of CRPC, diagnosis of metastases by imaging techniques, symptoms of CRPC, progression of CRPC, M0 and M1 management and therapeutic sequencing...
November 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/29097012/intensity-based-dual-model-method-for-generation-of-synthetic-ct-images-from-standard-t2-weighted-mr-images-generalized-technique-for-four-different-mr-scanners
#6
Lauri Koivula, Mika Kapanen, Tiina Seppälä, Juhani Collan, Jason A Dowling, Peter B Greer, Christian Gustafsson, Adalsteinn Gunnlaugsson, Lars E Olsson, Leonard Wee, Juha Korhonen
BACKGROUND AND PURPOSE: Recent studies have shown that it is possible to conduct entire radiotherapy treatment planning (RTP) workflow using only MR images. This study aims to develop a generalized intensity-based method to generate synthetic CT (sCT) images from standard T2-weighted (T2w) MR images of the pelvis. MATERIALS AND METHODS: This study developed a generalized dual model HU conversion method to convert standard T2w MR image intensity values to synthetic HU values, separately inside and outside of atlas-segmented bone volume contour...
October 30, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29082604/-68-ga-psma-pet-ct-for-the-detection-of-bone-metastases-in-prostate-cancer-a-systematic-review-of-the-published-literature
#7
Helle D Zacho, Julie B Nielsen, Uwe Haberkorn, Louise Stenholt, Lars J Petersen
BACKGROUND: (68) Ga-labelled prostate-specific membrane antigen (PSMA) is a promising PET ligand for the detection of prostate cancer. Little attention has been given to the ability of (68) Ga-PSMA PET/CT to detect malignant bone lesions and whether this approach is superior to existing bone imaging modalities. AIM: To review the existing data of (68) Ga-PSMA PET/CT for the diagnosis of bone metastases in prostate cancer. METHODS: Systematic review of the peer-reviewed literature...
October 29, 2017: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/29051038/image-guided-radiation-therapy-strategies-for-pelvic-lymph-node-irradiation-in-high-risk-prostate-cancer-motion-and-margins
#8
Lucy Kershaw, Laila van Zadelhoff, Wilma Heemsbergen, Floris Pos, Marcel van Herk
PURPOSE: To quantify the relative motion of the pelvic lymph nodes (LNs), seminal vesicles (SV) and prostate and define indicative margins for image-guided radiotherapy based on bony anatomy or prostate correction strategies for a 3 or 6 degrees-of-freedom couch. METHODS AND MATERIALS: Nineteen patients had a planning computed tomography (CT) scan followed by a mean of 11 repeated CT scans during radiation therapy. The prostate, SV, and external and internal iliac LN regions on the left and right were outlined on each CT scan...
September 8, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29039785/prospective-comparison-of-f-18-choline-pet-ct-scan-versus-axial-mri-for-detecting-bone-metastasis-in-biochemically-relapsed-prostate-cancer-patients
#9
Wouter Huysse, Frédéric Lecouvet, Paolo Castellucci, Piet Ost, Valerie Lambrecht, Carlos Artigas, Marie-Laurence Denis, Kathia De Man, Louke Delrue, Lennart Jans, Aurélie De Bruycker, Filip De Vos, Gert De Meerleer, Karel Decaestecker, Valerie Fonteyne, Bieke Lambert
We compared fluor-18 choline positron emission tomography/computed tomography (PET/CT) and axial skeleton magnetic resonance imaging (MRI) prospectively obtained for the detection of bone metastases in non-castrated patients with biochemically recurrent prostate cancer following primary treatment. PET/CT was performed 45 min post-injection of 3-4 MBq/kg F-18 methyl choline. MRI included T1- and fluid sensitive T2-weighted images of the spine and pelvis. Readers were initially blinded from other results and all scans underwent independent double reading...
October 17, 2017: Diagnostics
https://www.readbyqxmd.com/read/29035995/internal-auditory-canal-tumor-as-an-incidental-finding-on-a-choline-pet-ct-scan-in-a-prostate-cancer-patient
#10
Julia Malamitsi, Roxanni Efthymiadou, Theodore Pipikos, Fani Vlachou, Vassilis Prassopoulos
An 84-year-old man with a history of prostate cancer, treated with radiotherapy, presented with an increase in PSA levels. F-choline PET/CT showed foci of increased choline uptake in L4 and L5 vertebrae, suggestive of bone metastases and another focus in the right cerebellopontine angle. A brain MRI revealed a focus of intense contrast enhancement in the same region, consistent with an acoustic neuroma.
October 13, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29033673/automated-bone-scan-index-as-predictors-of-survival-in-prostate-cancer
#11
Joko Wiyanto, Rini Shintawati, Budi Darmawan, Basuki Hidayat, Achmad Hussein Sundawa Kartamihardja
Prostate cancer (PCa) is the second most diagnosed cancer in men. Early diagnosis and right management of PCa is critical to reducing deaths; the life expectancy is the main factors to be considered in the management of PCa. Among patients who die from PCa, the incidence of skeletal involvement appears to be >85%. Bone scan (BS) is the most common method for monitoring bone metastases in patients with PCa. The extent of bone metastasis was also associated with patient survival until now there is no clinically useful technique for measuring bone tumors and includes this information in the risk assessment...
October 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28976369/regression-and-statistical-shape-model-based-substitute-ct-generation-for-mri-alone-external-beam-radiation-therapy-from-standard-clinical-mri-sequences
#12
Soumya Ghose, Peter B Greer, Jidi Sun, Peter Pichler, David Rivest-Henault, Jhimli Mitra, Haylea Richardson, Chris Wratten, Jarad Martin, Jameen Arm, Leah Best, Jason A Dowling
In MR only radiation therapy planning, generation of the tissue specific HU map directly from the MRI may improve radiation therapy planning. The aim of the work is to generate and validate substitute CT (sCT) scans generated from standard T2 weighted MR pelvic scans in prostate radiation therapy dose planning. A Siemens Skyra 3T MRI scanner with laser bridge, flat couch and pelvic coil mounts was used to scan 39 patients scheduled for external beam radiation therapy for localized prostate cancer. For sCT generation a whole pelvis MRI was acquired...
October 4, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28976337/incidental-tc-99m-methylene-diphosphonate-uptake-in-an-active-thyroid-nodule
#13
Derya Çayır, Mine Araz, Şafak Akın, Melia Karaköse, Erman Çakal
Tc-99m-methylene diphosphonate (MDP) whole body scintigraphy is the method of choice for detection of metastatic bone diseases. It is primarily used to help diagnose various bone-related conditions such as primary or metastatic cancer of the bone, location of bone inflammation, and fractures that may not be visible on traditional X-ray images, as well as detection of bone damage due to infections and other conditions. In addition, bone scanning is often used for the follow-up or evaluation of response to treatment in some malignancies like prostate and breast cancers...
October 3, 2017: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/28976334/super-scan-caused-by-parathyroid-carcinoma-observed-both-in-18-f-fdg-pet-ct-scan-and-tc-99m-mdp-bone-scintigraphy
#14
İsa Burak Güney, Semra Paydaş, Hüseyin Tuğsan Ballı
Super scan is a well-known finding described in skeletal scintigraphy characterized by uniform symmetrically increased radiopharmaceutical uptake by bones and consequently diminished renal parenchymal activity. Sy et al. hypothesized that the faint visualization of renal cortex in bone scintigraphy might be the result of increased uptake of radiopharmaceutical by pathologic bones and reduced phosphate excretion. The super scan on (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) has been observed in various conditions such as prostate cancer, lung cancer, renal adenocarcinoma, gastric cancer and primitive neuroectodermal tumor of the kidney...
October 3, 2017: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/28975570/ra-223-spect-for-semi-quantitative-analysis-in-comparison-with-tc-99m-hmdp-spect-phantom-study-and-initial-clinical-experience
#15
Yoshiki Owaki, Tadaki Nakahara, Takeo Kosaka, Junichi Fukada, Atsuhiro Kumabe, Akira Ichimura, Mikoto Murakami, Kiyotaka Nakajima, Masahiro Fukushi, Kazumasa Inoue, Mototsugu Oya, Masahiro Jinzaki
BACKGROUND: Image-based measurement of absorbed dose of Ra-223 dichloride may be useful in predicting therapeutic outcome in patients with castration-resistant prostate cancer (CRPC). In general, SPECT has been found to be more accurate than planar imaging in terms of lesion-based analysis. The aims of this study were to assess the feasibility and clinical usefulness of Ra-223 SPECT. The energy spectrum of Ra-223 and SPECT images of a cylindrical phantom with a hot rod were obtained to determine the collimator candidates and energy window settings suitable for clinical Ra-223 SPECT (basic study A)...
October 3, 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28878857/unusual-soft-tissue-uptake-of-f-18-sodium-fluoride-in-three-patients-undergoing-f-18-naf-pet-ct-bone-scans-for-prostate-cancer
#16
Andrew S Hawkins, Brandon A Howard
Three males aged 71 to 80 years with known stage IV metastatic prostate cancer underwent F-18 sodium fluoride (NaF) PET/CT to assess osseous metastatic disease burden and stability. In addition to F-18 NaF avid known osseous metastases, each patient also exhibited increased F-18 NaF activity in soft tissues. The first patient exhibited multiple F-18 NaF avid enlarged retroperitoneal and pelvic lymph nodes on consecutive PET/CT scans. The second patient demonstrated an F-18 NaF avid thyroid nodule on consecutive PET/CT scans...
September 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28872544/soft-tissue-response-on-18f-fluorocholine-pet-ct-in-metastatic-castrate-resistant-prostate-cancer-treated-with-223ra-dichloride-a-possible-abscopal-effect
#17
Sandi A Kwee, John Lim, Marc N Coel
Two patients with castrate-resistant prostate cancer and symptomatic skeletal metastases underwent F-fluorocholine PET/CT prior to treatment with Ra-dichloride to reveal additional active lesions in the prostate gland and lymph nodes. Subsequent scans performed at the midpoint and end of Ra-dichloride therapy showed resolution of this soft tissue activity alongside declining bone lesion activity. Concomitant increases in plasma interleukin 6 were detected, suggesting that immune system activation may have mediated the soft tissue response...
September 1, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28868503/does-t1-and-diffusion-weighted-magnetic-resonance-imaging-give-value-added-than-bone-scintigraphy-in-the-follow-up-of-vertebral-metastasis-of-prostate-cancer
#18
Dong Hoon Lee, Jong Kil Nam, Hee Suk Jung, Seong Jang Kim, Moon Kee Chung, Sung-Woo Park
PURPOSE: To evaluate the effectiveness of limited Magnetic Resonance (MR) images including T1- and diffusion-weighted image (DWI) for monitoring vertebral metastasis in patients with prostate cancer. MATERIALS AND METHODS: From July 2014 to November 2016, patients diagnosed with spinal metastasis from prostate cancer using 99mTc bone scintigraphy were enrolled. Regardless of the primary local therapy, the changes in spinal metastasis were followed up using bone scan and biparametric MR (T1+DWI)...
September 2017: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/28864632/radium-223-therapy-of-advanced-metastatic-castration-resistant-prostate-cancer-quantitative-assessment-of-skeletal-tumor-burden-for-prognostication-of-clinical-outcome-and-hematological-toxicity
#19
Marie Øbro Fosbøl, Peter Meidahl Petersen, Andreas Kjaer, Jann Mortensen
Aim: To investigate the prognostic value of quantitative assessment of skeletal tumor burden on bone scintigraphy (Bone Scan Index) in patients with advanced metastatic castration-resistant prostate cancer (mCRPC) receiving Radium-223-dichloride ((223)RaCl2). We hypothesize that Bone Scan Index (BSI) can serve as a prognostic biomarker of overall survival (OS) and hematological toxicity, as well as a tool for response assessment in patients with mCRPC treated with (223)RaCl2Methods: Retrospective study of the Danish cohort of mCRPC patients who received (223)RaCl2 therapy between March 2014 and October 2015 and for whom a baseline bone scintigraphy was available...
September 1, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28854948/novel-three-dimensional-bone-mapping-software-can-help-assess-progression-of-osseous-metastases-from-routine-ct
#20
D Thurtle, G M Treece, T Barrett, V J Gnanapragasam
Imaging of bone metastasis response to therapy is a research priority. Stradwin is a new software-tool, with demonstrated sub-voxel accuracy in assessing cortical bone properties from routine CT. We applied this technology to the context of osseous metastases, with particular focus on disease progression using prostate cancer as a model. 3D-rendered 'bone-maps' were produced for 20 men with advanced prostate cancer, including a sub-cohort of 9 who had undergone serial scans. Correlation between baseline interpretation and assessments of progression between modalities was assessed...
August 30, 2017: Radiation Oncology
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