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Bone scans in prostate cancer

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https://www.readbyqxmd.com/read/29766246/comparison-of-68-ga-ga-psma-11-pet-ct-with-18-f-naf-pet-ct-in-the-evaluation-of-bone-metastases-in-metastatic-prostate-cancer-patients-prior-to-radionuclide-therapy
#1
Christian Uprimny, Anna Svirydenka, Josef Fritz, Alexander Stephan Kroiss, Bernhard Nilica, Clemens Decristoforo, Roland Haubner, Elisabeth von Guggenberg, Sabine Buxbaum, Wolfgang Horninger, Irene Johanna Virgolini
AIM: The purpose of this study was to investigate the diagnostic performance of 68 Ga-PSMA-11 PET/CT in the evaluation of bone metastases in metastatic prostate cancer (PC) patients scheduled for radionuclide therapy in comparison to [18 F]sodium fluoride (18 F-NaF) PET/CT. METHODS: Sixteen metastatic PC patients with known skeletal metastases, who underwent both 68 Ga-PSMA-11 PET/CT and 18 F-NaF PET/CT for assessment of metastatic burden prior to radionuclide therapy, were analysed retrospectively...
May 16, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29757474/automated-patient-specific-transperineal-ultrasound-probe-setups-for-prostate-cancer-patients-undergoing-radiotherapy
#2
Saskia Maria Camps, Frank Verhaegen, Ben G L Vanneste, Peter H N de With, Davide Fontanarosa
PURPOSE: The use of ultrasound imaging is not widespread in prostate cancer radiotherapy workflows, despite several advantages (e.g. allowing real-time volumetric organ tracking). This can be partially attributed to the need for a trained operator during acquisition and interpretation of the images. We introduce and evaluate an algorithm that can propose a patient-specific transperineal ultrasound probe setup, based on a CT scan and anatomical structure delineations. The use of this setup during the simulation and treatment stage could improve usability of ultrasound imaging for relatively untrained operators (radiotherapists with less than one year experience with ultrasound)...
May 14, 2018: Medical Physics
https://www.readbyqxmd.com/read/29752180/-177-lu-psma-617-radionuclide-treatment-in-patients-with-metastatic-castration-resistant-prostate-cancer-lupsma-trial-a-single-centre-single-arm-phase-2-study
#3
Michael S Hofman, John Violet, Rodney J Hicks, Justin Ferdinandus, Sue Ping Thang, Tim Akhurst, Amir Iravani, Grace Kong, Aravind Ravi Kumar, Declan G Murphy, Peter Eu, Price Jackson, Mark Scalzo, Scott G Williams, Shahneen Sandhu
BACKGROUND: Progressive metastatic castration-resistant prostate cancer is a highly lethal disorder and new effective therapeutic agents that improve patient outcomes are urgently needed. Lutetium-177 [177 Lu]-PSMA-617, a radiolabelled small molecule, binds with high affinity to prostate-specific membrane antigen (PSMA) enabling beta particle therapy targeted to metastatic castration-resistant prostate cancer. We aimed to investigate the safety, efficacy, and effect on quality of life of [177 Lu]-PSMA-617 in men with metastatic castration-resistant prostate cancer who progressed after standard treatments...
May 7, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29742607/fatal-intracranial-hemorrhage-due-to-thrombocytopenia-in-a-patient-with-castration-resistant-prostate-cancer-showing-extensive-bone-uptake-of-injected-223ra-dichloride
#4
Tadaki Nakahara, Yoshiki Owaki, Takeo Kosaka, Junichi Fukada, Akira Ichimura, Masahiro Jinzaki
A 64-year-old man with castration-resistant prostate cancer received Ra injection to treat bone metastases. The patient underwent a Ra SPECT scan after the first Ra injection in which there was increased uptake all over the spine. Spine-to-background activity ratio in the patient was approximately three times greater than normal spine-to-background activity ratios in Ra SPECT obtained from the other patients. Eight days after the fifth injection, the patient exhibited a very poor neurologic examination and died of intracranial hemorrhage due to severe thrombocytopenia (platelet counts, 23,000/mm)...
April 30, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29730256/the-role-of-imaging-in-prostate-cancer-care-pathway-novel-approaches-to-urologic-management-challenges-along-ten-imaging-touch-points
#5
REVIEW
Qian Li, Feixiang Xiang, Xueying Lin, Joseph R Grajo, Long Yang, Yufeng Xu, Yu Duan, Urvi Vyas, Mukesh Harisinghani, Umar Mahmood, Anthony E Samir
We map out a typical prostate cancer care pathway through discussion of updates on modern imaging. Multiparametric MRI (mpMRI) is the most sensitive and specific imaging tool for diagnosis and local staging, transrectal ultrasound remains the most widely used technique for prostate biopsy guidance, CT and bone scan are useful in initial staging and recurrence detection. Novel imaging techniques in ultrasound elastography and mpMRI allow for increased lesion detection sensitivity and have the potential to enhance biopsy, while the development of new PET radiotracers has great promise for improved detection of local and metastatic disease in patients with biochemical recurrence...
May 3, 2018: Urology
https://www.readbyqxmd.com/read/29728144/a-prospective-study-to-evaluate-the-intra-individual-reproducibility-of-bone-scans-for-quantitative-assessment-in-patients-with-metastatic-prostate-cancer
#6
Mariana Reza, Reza Kaboteh, May Sadik, Anders Bjartell, Per Wollmer, Elin Trägårdh
BACKGROUND: The Bone Scan Index (BSI) is used to quantitatively assess the total tumour burden in bone scans of patients with metastatic prostate cancer. The clinical utility of BSI has recently been validated as a prognostic imaging biomarker. However, the clinical utility of the on-treatment change in BSI is dependent on the reproducibility of bone scans. The objective of this prospective study is to evaluate the intra-patient reproducibility of two bone scan procedures performed at a one-week interval...
May 4, 2018: BMC Medical Imaging
https://www.readbyqxmd.com/read/29726071/a-prospective-randomised-multi-centre-study-of-the-impact-of-ga-68-psma-pet-ct-imaging-for-staging-high-risk-prostate-cancer-prior-to-curative-intent-surgery-or-radiotherapy-propsma-study-clinical-trial-protocol
#7
Michael S Hofman, Declan G Murphy, Scott G Williams, Tatenda Nzenza, Alan Herschtal, Richard De Abreu Lourenco, Dale L Bailey, Ray Budd, Rodney J Hicks, Roslyn J Francis, Nathan Lawrentschuk
INTRODUCTION: Accurate staging of patients with prostate cancer is important for therapeutic decision making. Relapse following surgery or radiotherapy of curative intent is not uncommon and, in part, represents a failure of staging with current diagnostic imaging techniques to detect disease spread. Prostate-specific-membrane-antigen (PSMA) positron emission tomography / computed tomography (PET/CT) is a new whole body scanning technique that enables visualisation of prostate cancer with high contrast...
May 3, 2018: BJU International
https://www.readbyqxmd.com/read/29719480/nuclear-medicine-in-prostate-cancer-a-new-era-for-radiotracers
#8
REVIEW
Vincenzo Cuccurullo, Giuseppe Danilo Di Stasio, Luigi Mansi
Natural history of prostate cancer (PCa) is extremely variable, as it ranges from indolent and slow growing tumors to highly aggressive histotypes. Genetic background and environmental factors co-operate to the genesis and clinical manifestation of the tumor and include among the others race, family, specific gene variants (i.e., BRCA1 and BRCA2 mutations), acute and chronic inflammation, infections, diet and drugs. In this scenario, remaining actual the clinical interest of bone scan (BS) in detecting skeletal metastases, an important role in diagnostic imaging may be also carried out by, positron emission tomography/computed tomography (PET/CT) and PET/magnetic resonance imaging (PET/MRI), which combine morphological information provided by CT and MRI with functional and metabolic data provided by PET acquisitions...
April 2018: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29670722/stafne-s-bone-defect-in-a-metastatic-prostate-cancer-patient-a-diagnostic-conundrum
#9
Wagner-Gomes da Silva, Aristilia-Tahara Kemp, Alan-Roger Dos Santos-Silva, Maria Del Pilar-Estevez Diz, Thais-Bianca Brandão
Stafne's bone defect (SBD) is an uncommon bone alteration that affects the mandible and usually presents as an asymptomatic radiolucency located in the posterior region of body or angle of the mandible, below the alveolar canal. Although clinical and radiographic features are more often sufficient for the diagnosis, other lesions and bone alterations have been described in the differential diagnosis and may lead to a misinterpretation and an incorrect diagnosis. Herein, we report a case of an 89-yearold man with metastatic prostate cancer to multiple bones, presenting an asymptomatic solitary well-defined radiolucent image on the right side of the posterior body of the mandible, in close contact with its inferior border...
January 2018: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29668486/the-role-of-provider-characteristics-in-the-selection-of-surgery-or-radiation-for-localized-prostate-cancer-and-association-with-quality-of-care-indicators
#10
Raj Satkunasivam, Mary Lo, Mariana Stern, Inderbir S Gill, Steven Fleming, Xiao-Cheng Wu, Roger T Anderson, Trevor D Thompson, Ann S Hamilton
INTRODUCTION: We sought to identify the role of provider and facility characteristics in receipt of radical prostatectomy (RP) or external beam radiation therapy (EBRT) and adherence to quality of care measures in men with localized prostate cancer (PCa). MATERIALS AND METHODS: Subjects included 2861 and 1630 men treated with RP or EBRT, respectively, for localized PCa whose records were reabstracted as part of the Centers for Disease Control and Prevention Breast and Prostate Patterns of Care Study...
April 17, 2018: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29666893/pitfalls-in-bone-density-monitoring-in-prostate-cancer-during-anti-resorptive-treatment
#11
Y-M Cheung, S K Ramchand, M Grossmann
A 74-year-old man presented to the Andrology Clinic for management of potential complications of androgen deprivation therapy for prostate cancer. He had a rising prostate-specific antigen with a concurrent rise in alkaline phosphatase and bone remodeling markers. This was despite treatment with a radical prostatectomy, androgen deprivation, and anti-resorptive therapy. A follow-up dual-energy X-ray absorptiometry scan revealed a marked increase in his bone mineral density at both the lumbar spine and femoral neck...
April 17, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29663686/-68-ga-psma-pet-ct-staging-prior-to-definitive-radiation-treatment-for-prostate-cancer
#12
George Hruby, Thomas Eade, Louise Emmett, Bao Ho, Ed Hsiao, Geoff Schembri, Linxin Guo, Carolyn Kwong, Julia Hunter, Keelan Byrne, Andrew Kneebone
AIM: To explore the utility of prostate specific membrane antigen (PSMA)-positron emission tomography (PET)/computed tomography (CT) in addition to conventional imaging prior to definitive external beam radiation treatment (EBRT) for prostate cancer. METHODS: All men undergoing PSMA-PET/CT prior to definitive EBRT for intermediate and high-risk prostate cancer were included in our ethics approved prospective database. For each patient, clinical and pathological results, in addition to scan results including site of PSMA positive disease and number of lesions, were recorded...
April 16, 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29663527/editorial-comment-to-role-of-bone-scan-index-in-the-prognosis-and-effects-of-therapy-on-prostate-cancer-with-bone-metastasis-study-design-and-rationale-for-the-multicenter-prostatic-cancer-registry-of-standard-hormonal-and-chemotherapy-using-bone-scan-index
#13
https://www.readbyqxmd.com/read/29627288/multiparametric-whole-body-mri-with-diffusion-weighted-imaging-and-adc-mapping-for-the-identification-of-visceral-and-osseous-metastases-from-solid-tumors
#14
Michael A Jacobs, Katarzyna J Macura, Atif Zaheer, Emmanuel S Antonarakis, Vered Stearns, Antonio C Wolff, Thorsten Feiweier, Ihab R Kamel, Richard L Wahl, Li Pan
RATIONALE AND OBJECTIVES: The purpose of this study was to investigate the use of multiparametric, whole-body, diffusion-weighted imaging (WB-DWI) and apparent diffusion coefficient (ADC) maps with T2 -weighted magnetic resonance imaging (MRI) at 3T for the detection and monitoring of metastatic disease in patients. MATERIALS AND METHODS: Fifty-four participants (32 healthy subjects and 22 patients) were scanned with WB-DWI methods using a 3T MRI scanner. Axial, sagittal, or coronal fat-suppressed T2 -weighted (T2 WI), T1 -weighted (T1 WI), and DWI images were acquired...
April 4, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29609897/increased-prostate-cancer-glucose-metabolism-detected-by-18-f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-in-localised-gleason-8-10-prostate-cancers-identifies-very-high-risk-patients-for-early-recurrence-and-resistance-to-castration
#15
Etienne Lavallée, Michelle Bergeron, François-Alexandre Buteau, Annie-Claude Blouin, Nicolas Duchesnay, Thierry Dujardin, Rabi Tiguert, Louis Lacombe, Vincent Fradet, Molière Makao-Nguile, Yves Fradet, Jean-Mathieu Beauregard, Frédéric Pouliot
BACKGROUND: The accuracy of18 F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) to stage prostate cancer (PCa) is limited. However, Gleason 8-10 PCa and more aggressive metastatic PCa have been shown to exhibit a higher glycolytic activity. OBJECTIVE: To evaluate the potential of intraprostatic FDG uptake to prognose Gleason 8-10 PCa patients prior to prostatectomy, based on tumour intrinsic biology. DESIGN, SETTING, AND PARTICIPANTS: FDG-PET/CT and a bone scan were performed as a staging procedure prior to prostatectomy in 148 consecutive patients diagnosed with PCa with a Gleason sum of ≥8 at biopsy...
March 30, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29603079/effects-of-breast-and-prostate-cancer-metastases-on-lumbar-spine-biomechanics-rapid-in-silico-evaluation
#16
J Lorkowski, O Grzegorowska, M S Kozień, I Kotela
Metastases to distant organs are a frequent occurrence in cancer diseases. The skeletal system, especially the spine, is one such organ. The objective of this study was to apply a numerical modeling, using a finite element method (FEM), for the evaluation of deformation and stress in lumbar spine in bone metastases to the spine. We investigated 20 patients (10 women and 10 men) aged 38-81 years. In women, osteolytic lesions in lumbar spine accompanied breast cancer, in men it was prostate cancer. Geometry of FEM models were built based on CT scans of metastatic lumbar spine...
March 31, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29602821/a-prospective-comparison-of-18-f-sodium-fluoride-pet-ct-and-psma-targeted-18-f-dcfbc-pet-ct-in-metastatic-prostate-cancer
#17
Stephanie A Harmon, Ethan Bergvall, Esther Mena, Joanna H Shih, Stephen Adler, Yolanda McKinney, Sherif Mehralivand, Deborah E Citrin, Anna Couvillon, Ravi Madan, James Gulley, Ronnie C Mease, Paula M Jacobs, Martin G Pomper, Baris Turkbey, Peter L Choyke, M Liza Lindenberg
Purpose: The purpose of this study was to compare the diagnostic performance of 18 F-DCFBC positron emission tomography/computed tomography (PET/CT), a first generation 18 F-labelled prostate-specific membrane antigen (PSMA)-targeted agent, and 18 F-NaF PET/CT, a sensitive marker of osteoblastic activity, in a prospective cohort of patients with metastatic prostate cancer. Methods: Twenty-eight prostate cancer patients with metastatic disease on conventional imaging prospectively received up to four PET/CT scans...
March 30, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29579318/increased-resource-use-in-men-with-metastatic-prostate-cancer-does-not-result-in-improved-survival-or-quality-of-care-at-the-end-of-life
#18
Ron Golan, Adrien N Bernstein, Xiangmei Gu, Brian A Dinerman, Art Sedrakyan, Jim C Hu
BACKGROUND: Cancer care and end-of-life (EOL) care contribute substantially to health care expenditures. Outside of clinical trials, to our knowledge there exists no standardized protocol to monitor disease progression in men with metastatic prostate cancer (mPCa). The objective of the current study was to evaluate the factors and outcomes associated with increased imaging and serum prostate-specific antigen use in men with mPCa. METHODS: Using Surveillance, Epidemiology, and End Results-Medicare data from 2004 to 2012, the authors identified men diagnosed with mPCa with at least 6 months of follow-up...
March 26, 2018: Cancer
https://www.readbyqxmd.com/read/29572056/the-impact-of-the-choosing-wisely-campaign-in-urology
#19
Blayne Welk, Jennifer Winick-Ng, J Andrew McClure, Armando J Lorenzo, Girish Kulkarni, Michael Ordon
OBJECTIVE: To determine if 3 of the Canadian Urological Association's Choosing Wisely recommendations (released in 2013-2014) related to urologic care altered physician and patient behavior. METHODS: Administrative data from Ontario, Canada between 2008 and 2017 was used. We identified 3 cohorts: First, we determined how many men >66 years of age had a serum testosterone level before starting testosterone therapy. Second, we determined how many boys undergoing an orchiopexy underwent abdominal imaging before their surgery...
March 20, 2018: Urology
https://www.readbyqxmd.com/read/29559285/prognostic-value-of-18-f-fluoromethylcholine-positron-emission-tomography-computed-tomography-before-stereotactic-body-radiation-therapy-for-oligometastatic-prostate-cancer
#20
Matthijs Cysouw, Esther Bouman-Wammes, Otto Hoekstra, Alfons van den Eertwegh, Maartje Piet, Jeroen van Moorselaar, Ronald Boellaard, Max Dahele, Daniela Oprea-Lager
PURPOSE: To investigate the predictive value of [18 F]-fluoromethylcholine positron emission tomography/computed tomography (PET/CT)-derived parameters on progression-free survival (PFS) in oligometastatic prostate cancer patients treated with stereotactic body radiation therapy (SBRT). METHODS AND MATERIALS: In [18 F]-fluoromethylcholine PET/CT scans of 40 consecutive patients with ≤4 metachronous metastases treated with SBRT we retrospectively measured the number of metastases, standardized uptake values (SUVmean , SUVmax , SUVpeak ), metabolically active tumor volume (MATV), and total lesion choline uptake...
February 13, 2018: International Journal of Radiation Oncology, Biology, Physics
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