keyword
https://read.qxmd.com/read/38060258/risks-of-depression-anxiety-and-suicide-in-partners-of-men-with-prostate-cancer-a-national-cohort-study
#21
JOURNAL ARTICLE
Casey Crump, Pär Stattin, James D Brooks, Jan Sundquist, Alexis C Edwards, Kristina Sundquist, Weiva Sieh
BACKGROUND: A diagnosis of prostate cancer (PC) may cause psychosocial distress not only in a man but also his intimate partner. However, long-term risks of depression, anxiety, or suicide in partners of men with PC are largely unknown. METHODS: A national cohort study was conducted of 121,530 partners of men diagnosed with PC during 1998-2017 and 1,093,304 population-based controls in Sweden. Major depression, anxiety disorder, and suicide death were ascertained through 2018...
December 7, 2023: Journal of the National Cancer Institute
https://read.qxmd.com/read/38002324/plasma-androstenedione-concentration-can-discriminate-frail-versus-non-frail-men-with-prostate-cancer-under-androgen-deprivation-therapy
#22
JOURNAL ARTICLE
Mayra Alejandra Mafla-España, María Dolores Torregrosa, Manel Beamud-Cortés, Lorena Bermell-Marco, José Rubio-Briones, Omar Cauli
BACKGROUND: Androgen deprivation therapy (ADT) is a mainstay of prostate cancer in both adjuvant and palliative settings. Since androgens are crucial for functional status and psychological functions, we evaluated whether blood testosterone, androstenedione, or DHEA concentrations were associated with functional status and psychological alterations in patients with localised (PCa) or metastatic prostate cancer (mPCa) receiving ADT with analogues of luteinising hormone-releasing hormone (LHRH)...
November 13, 2023: Biomolecules
https://read.qxmd.com/read/37929256/family-wellbeing-and-sexual-health-of-patients-receiving-treatment-for-prostate-cancer
#23
JOURNAL ARTICLE
Carielle Joy Rio, Taichi Goto, Chao-Pin Hsiao, Alexander L R Ross, Leorey N Saligan
PURPOSE: Prostate cancer and its treatment may affect patients' sexual function and social wellbeing. This study investigated the relationship between social/family wellbeing and sexual health in patients with prostate cancer. Additionally, the moderating effect of clinical characteristics on this relationship was also explored. PATIENTS AND METHODS: This is a descriptive correlational study using baseline data of a longitudinal study enrolling 137 patients with prostate cancer...
2023: Cancer Management and Research
https://read.qxmd.com/read/37905476/are-couple-based-psychological-interventions-beneficial-for-the-mental-health-of-prostate-cancer-patients-and-their-spouses-a-systematic-review-and-meta-analysis
#24
REVIEW
Bin Shen, Jianhong Sun, Zhenliang Yu, Gang Xu, Yaoying Zhou
As the survival rates for prostate cancer (PCa) have improved, there has been an increasing focus on the mental health of couples affected by this condition. There have been several couple-based psychological interventions, and yet the impact of this treatment modality on the mental health of PCa patients and their spouses is unclear. Consequently, a systematic search was conducted in PubMed, Embase, Cochrane, LILACS, and Web of Science up to March 2023 for randomized controlled trials (RCTs) addressing the impacts of couple-based psychological interventions on both PCa patients and their spouses...
October 31, 2023: Clinical Psychology & Psychotherapy
https://read.qxmd.com/read/37887129/ruthenium-anchored-carbon-sphere-customized-sensor-for-the-selective-amperometric-detection-of-melatonin
#25
JOURNAL ARTICLE
Sivaguru Jayaraman, Thenmozhi Rajarathinam, Hyeon-Geun Jang, Dinakaran Thirumalai, Jaewon Lee, Hyun-Jong Paik, Seung-Cheol Chang
Melatonin (MT), a pineal gland hormone, regulates the sleep/wake cycle and is a potential biomarker for neurodegenerative disorders, depression, hypertension, and several cancers, including prostate cancer and hepatocarcinoma. The amperometric detection of MT was achieved using a sensor customized with ruthenium-incorporated carbon spheres (Ru-CS), possessing C- and O-rich catalytically active Ru surfaces. The non-covalent interactions and ion-molecule adducts between Ru and CS favor the formation of heterojunctions at the sensor-analyte interface, thus accelerating the reactions towards MT...
October 18, 2023: Biosensors
https://read.qxmd.com/read/37867158/mental-health-outcomes-in-a-population-based-cohort-of-patients-with-prostate-cancer
#26
JOURNAL ARTICLE
Siqi Hu, Chun-Pin Chang, John Snyder, Vikrant Deshmukh, Michael Newman, Ankita Date, Carlos Galvao, Benjamin Haaland, Christina A Porucznik, Lisa H Gren, Alejandro Sanchez, Shane Lloyd, Brock O'Neil, Mia Hashibe
BACKGROUND: Few studies have evaluated mental health disorders comprehensively among patients with prostate cancer on long-term follow-up. The primary aim of our study was to assess the incidence of mental health disorders among patients with prostate cancer compared with a general population cohort. A secondary aim was to investigate potential risk factors for mental health disorders among patients with prostate cancer. METHODS: Cohorts of 18 134 patients with prostate adenocarcinomas diagnosed between 2004 and 2017 and 73470 men without cancer matched on age, birth state, and follow-up time were identified...
October 23, 2023: Journal of the National Cancer Institute
https://read.qxmd.com/read/37862103/preference-elicitation-and-treatment-decision-making-among-men-diagnosed-with-prostate-cancer-randomized-controlled-trial-results-of-healium
#27
RANDOMIZED CONTROLLED TRIAL
Michael A Diefenbach, Allison Marziliano, Erin K Tagai, Halie Pfister, Emmanuel Lapitan, Simon J Hall, Manish Vira, Said Ibrahim, Kelli Aibel, Alexander Kutikov, Eric M Horwitz, Curtis Miyamoto, Adam C Reese, Suzanne M Miller
BACKGROUND: Elicitation of patients' preferences is an integral part of shared decision-making, the recommended approach for prostate cancer decision-making. Existing decision aids for this population often do not specifically focus on patients' preferences. Healium is a brief interactive web-based decision aid that aims to elicit patients' treatment preferences and is designed for a low health literate population. OBJECTIVE: This study used a randomized controlled trial to evaluate whether Healium, designed to target preference elicitation, is as efficacious as Healing Choices, a comprehensive education and decision tool, in improving outcomes for decision-making and emotional quality of life...
October 20, 2023: Journal of Medical Internet Research
https://read.qxmd.com/read/37845136/emas-position-statement-testosterone-replacement-therapy-in-older-men
#28
JOURNAL ARTICLE
George A Kanakis, Riccardo Pofi, Dimitrios G Goulis, Andrea M Isidori, Eleni Armeni, C Tamer Erel, Ivan Fistonić, Timothy Hillard, Angelica-Lindén Hirschberg, Blazej Meczekalski, Nicolás Mendoza, Alfred O Mueck, Tommaso Simoncini, Petra Stute, Dorenda van Dijken, Margaret Rees, Irene Lambrinoudaki
INTRODUCTION: Late-onset hypogonadism is the clinical entity characterised by low testosterone concentrations associated with clinical symptoms in the absence of organic disease in ageing men. It has been associated with metabolic syndrome, reduced bone mineral density, and increased cardiovascular morbidity and mortality risk. Although testosterone replacement therapy (TRT) reverses most of these conditions in young hypogonadal men, the risk/benefit ratio of TRT in older men is debatable...
December 2023: Maturitas
https://read.qxmd.com/read/37838002/impact-of-prostate-cancer-related-genitourinary-radiation-injury-on-mental-health-diagnosis-and-treatment-assessment-of-55-425-men
#29
JOURNAL ARTICLE
Kevin Hebert, Ann Bruno, Rano Matta, Joshua Horns, Niraj Paudel, Rupam Das, James Hotaling, Benjamin McCormick, Jeremy B Myers
OBJECTIVE: To investigate the association of low-grade radiation injury (LGRI) and high-grade radiation injury (HGRI) following prostate cancer treatment with mental health diagnoses and therapy. METHODS: A retrospective study of men diagnosed with prostate cancer who were treated with radiotherapy. Men were followed to assess for LGRI or HGRI using IBM MarketScan. Cohorts included: no injury (no-RI), LGRI, HGRI, and controls. Mental health diagnoses and related treatment (medication/therapy) were identified using ICD-10 codes, CPT codes, and national drug codes...
October 12, 2023: Urology
https://read.qxmd.com/read/37818046/multimorbidity-in-people-living-with-and-beyond-cancer-a-scoping-review
#30
REVIEW
Tahania A Ahmad, Dipesh P Gopal, Claude Chelala, Abu Zm Dayem Ullah, Stephanie Jc Taylor
Globally, both cancer incidence and survival are increasing. Early cancer detection and improved treatment means many people with cancer will survive for ten or more years following diagnosis. Multimorbidity, defined as two or more chronic conditions, is up to three times higher in people living with and beyond cancer (LWBC) compared to the general population. This scoping review summarises the research evidence on the association between cancer and multimorbidity in people LWBC. It explores five key domains in people LWBC: 1) prevalence of multimorbidity, 2) association between ethnicity and socio-economic status (SES) and multimorbidity, 3) association between health status and multimorbidity, 4) adverse health consequences of cancer and related treatments, and 5) whether being a cancer survivor impacts treatment received for multimorbidity...
2023: American Journal of Cancer Research
https://read.qxmd.com/read/37789603/prognostic-factors-for-mental-wellbeing-in-prostate-cancer-a%C3%A2-systematic-review-and-meta-analysis
#31
REVIEW
Neel Vyas, Oliver Brunckhorst, Jack B Fanshawe, Robert Stewart, Prokar Dasgupta, Kamran Ahmed
OBJECTIVES: To evaluate the evidence base for patient, oncological, and treatment prognostic factors associated with multiple mental wellbeing outcomes in prostate cancer patients. METHODS: We performed a literature search of MEDLINE, EMBASE, and CINAHL databases including studies evaluating patient, oncological, or treatment factors against one of five mental wellbeing outcomes; depression, anxiety, fear of cancer recurrence, masculinity, and body image perception...
November 2023: Psycho-oncology
https://read.qxmd.com/read/37788996/effects-of-vortioxetine-on-hippocampal-related-cognitive-impairment-induced-in-rats-by-androgen-deprivation-as-a-model-of-prostate-cancer-treatment
#32
JOURNAL ARTICLE
Alexandra M Vaiana, Yidong Chen, Jonathan Gelfond, Teresa L Johnson-Pais, Robin J Leach, Chethan Ramamurthy, Ian M Thompson, David A Morilak
Advances in prostate cancer treatment have significantly improved survival, but quality of life for survivors remains an under-studied area of research. Androgen deprivation therapy (ADT) is a foundational treatment for advanced prostate cancer and is used as an adjuvant for prolonged periods in many high-risk, localized tumors. More than half of patients treated with ADT experience debilitating cognitive impairments in domains such as spatial learning and working memory. In this study, we investigated the effects of androgen deprivation on hippocampal-mediated cognition in rats...
October 3, 2023: Translational Psychiatry
https://read.qxmd.com/read/37787025/effects-of-omega-3-supplementation-on-psychological-symptoms-in-men-with-prostate-cancer-secondary-analysis-of-a-double-blind-placebo-controlled-randomized-trial
#33
RANDOMIZED CONTROLLED TRIAL
Josée Savard, Hanane Moussa, Jean-François Pelletier, Pierre Julien, Louis Lacombe, Rabi Tiguert, Yves Caumartin, Thierry Dujardin, Paul Toren, Frédéric Pouliot, Michele Lodde, Yves Fradet, Karine Robitaille, Vincent Fradet
BACKGROUND: In the general population, a higher omega-3 polyunsaturated fatty acids intake is associated with lower levels of several psychological symptoms, especially depression. However, the existing evidence in cancer is equivocal. METHODS: This phase IIB double-blind, placebo-controlled trial was aimed at comparing the effects of eicosapentaenoic acid monoacylglyceride (MAG-EPA) supplementation and high oleic acid sunflower oil (HOSO; placebo) on depression levels (primary outcome) and other symptoms (anxiety, fear of cancer recurrence, fatigue, insomnia, perceived cognitive impairments; secondary outcomes)...
October 2023: Cancer Medicine
https://read.qxmd.com/read/37784459/quality-of-life-results-of-addition-of-androgen-deprivation-therapy-and-pelvic-lymph-node-treatment-to-prostate-bed-salvage-radiotherapy-nrg-oncology-rtog-0534-spport
#34
JOURNAL ARTICLE
D W Bruner, T G Karrison, A Pollack, J M Michalski, A Balogh, G Rodrigues, E M Horwitz, S Faria, A S Camarata, R J Lee, H Lukka, M J Zelefsky, W Seiferheld, H M Sandler, B Movsas
PURPOSE/OBJECTIVE(S): Report the quality of life (QOL) analysis of the SPPORT trial of men with a detectable prostate specific antigen (PSA) after prostatectomy for prostate cancer randomized to (Arm 1) salvage prostate bed radiotherapy (PBRT), (Arm 2) 4-6 months of short-term androgen deprivation therapy (STADT) + PBRT, and (Arm 3) pelvic lymph node radiotherapy (PLNRT) + STADT + PBRT. Primary analysis established a benefit of adding PLNRT and STADT to PBRT...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/37784276/risk-of-sexual-dysfunction-in-men-treated-with-pelvic-radiation-therapy-for-locally-advanced-rectal-cancer-20-years-of-experience-with-451-patients
#35
JOURNAL ARTICLE
K H Patel, K R Tringale, N Kim, L Boe, M Reyngold, A J Wu, M Zinovoy, P B Romesser, J Cuaron, E Pappou, M Nusrat, J Mulhall, C H Crane, C Hajj
PURPOSE/OBJECTIVE(S): Radiation therapy (RT) is commonly used in the treatment of locally advanced rectal cancer (LARC), but data on its impact on men's sexual health is limited. Given the rising incidence of rectal cancer in younger men, sexual function is an important quality of life factor. We hypothesized that men with LARC treated with RT would be at increased risk of sexual dysfunction compared to men who did not receive RT. MATERIALS/METHODS: This is a single institution retrospective analysis of outcomes of men ≤50 years diagnosed with LARC between 1999 and 2019...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/37777435/switching-from-the-transrectal-to-the-transperineal-route-a-single-center-experience
#36
JOURNAL ARTICLE
A Brun, C Klein, G Capon, E Alezra, V Estrade, P Blanc, J C Bernhard, F Bladou, G Robert
INTRODUCTION: This study aimed to evaluate the feasibility of switching from transrectal to transperineal prostate biopsy (TPPBx) by urologists with no previous experience with TPPBx. Material A monocentric clinical study with exhaustive and consecutive inclusions was conducted between January and November 2021, including 105 consecutive patients who underwent TPPBx performed by two senior urologists with no previous experience of TPPBx (GR, FB). Biopsies were performed under local anesthesia (LA) without antibioprophylaxis...
September 28, 2023: Progrès en Urologie
https://read.qxmd.com/read/37770668/cognitive-behavioral-stress-management-program-reduces-postoperative-psychological-pressure-and-improves-life-quality-in-prostate-cancer-patients
#37
JOURNAL ARTICLE
Huimin Sui, Meiling Guo
OBJECTIVE: Cognitive-behavioral stress management (CBSM) improves mental status and quality of life (QoL) in cancer patients, while its impact on prostate cancer (PC) patients remains unknown. Thus, the study aimed at investigating the potency of CBSM program in ameliorating postoperative anxiety, depression, and QoL in PC patients. METHODS: Totally, 160 postoperative PC patients were consecutively recruited followed by random assignments to either CBSM (N = 81) or usual care (UC) (N = 79) group as a 1:1 ratio...
September 29, 2023: Irish Journal of Medical Science
https://read.qxmd.com/read/37754206/inequities-in-definitive-treatment-for-localized-prostate-cancer-among-those-with-clinically-significant-mental-health-disorders
#38
JOURNAL ARTICLE
Joshua Cabral, Sarah K Holt, Samuel L Washington, Erin Dwyer, Jenney R Lee, Erika M Wolff, John L Gore, Yaw A Nyame
INTRODUCTION: Patients with mental health disorders are at risk for receiving inequitable cancer treatment, likely resulting from various structural, social, and health-related factors. This study aims to assess the relationship between mental health disorders and the use of definitive treatment in a population-based cohort of those with localized, clinically significant prostate cancer. METHODS: We conducted a cohort study analysis in SEER (Surveillance, Epidemiology, and End Results)-Medicare (2004-2015)...
September 26, 2023: Urology Practice
https://read.qxmd.com/read/37719041/relationship-between-seminal-vesicle-displacement-and-distribution-of-hydrogel-spacer-within-the-perirectal-space-in-prostate-radiotherapy
#39
JOURNAL ARTICLE
Kenji Makita, Yasushi Hamamoto, Hiromitsu Kanzaki, Kei Nagasaki, Katsuyoshi Hashine
The influence of a hydrogel spacer (HS) on seminal vesicle (SV) displacement in prostate radiotherapy was examined in the present study. A total of 20 patients with prostate cancer, who received intensity-modulated radiation therapy (IMRT), were enrolled. Computed tomography and magnetic resonance imaging were performed before and after HS insertion within the peripheral space for IMRT planning. Before and after HS insertion, The SV was delineated, and the amount of SV displacement was evaluated. Large SV cranial displacements (≥0...
October 2023: Molecular and Clinical Oncology
https://read.qxmd.com/read/37710022/-pain-related-stigma-in-patients-with-breast-colon-prostate-or-lung-cancer-results-of-a-bicentric-register-based-cross-sectional-study
#40
JOURNAL ARTICLE
A Roicke, P Esser, B Hornemann, J Ernst
BACKGROUND: Studies on cancer patients show a moderately high relevance of perceived stigmatization. However, no studies have explored the perceived stigmatization in relation to cancer-associated pain. In this work, we analysed the relationship between pain and perceived stigmatization across a large sample of four major cancer entities. METHODS: Quantitative data of 858 patients (45.6% women, mean age 60.7 years) with breast, bowel, lung and prostate cancer were evaluated in a register-based, bicentric study...
September 14, 2023: Der Schmerz
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