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Prostate cancer and depression

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https://www.readbyqxmd.com/read/28208524/re-association-of-androgen-deprivation-therapy-with-depression-in-localized-prostate-cancer
#1
David F Penson
No abstract text is available yet for this article.
March 2017: Journal of Urology
https://www.readbyqxmd.com/read/28181675/a-placebo-controlled-double-blinded-randomized-pilot-study-of-combination-phytotherapy-in-biochemically-recurrent-prostate-cancer
#2
M Diana van Die, Scott G Williams, Jon Emery, Kerry M Bone, Jeremy M G Taylor, Elizabeth Lusk, Marie V Pirotta
BACKGROUND: Men with biochemical recurrence of prostate cancer following local therapies often use natural supplements in an attempt to delay metastases and/or avoid the need for more aggressive treatments with undesirable side-effects. While there is a growing body of research into phytotherapeutic agents in this cohort, with some promising results, as yet no definitive recommendations can be made. This pilot study was undertaken to assess the feasibility of a fully-powered study to examine the effects of this phytotherapeutic intervention (containing turmeric, resveratrol, green tea and broccoli sprouts) on PSA doubling time in men with biochemical recurrence with a moderate PSA rise rate...
February 9, 2017: Prostate
https://www.readbyqxmd.com/read/28169575/a-clinician-referral-and-12-week-exercise-training-programme-for-men-with-prostate-cancer-outcomes-to-12-months-of-the-engage-cluster-randomised-controlled-trial
#3
Cadeyrn J Gaskin, Melinda Craike, Mohammadreza Mohebbi, Kerry S Courneya, Patricia M Livingston
BACKGROUND: The ENGAGE (efficacy of a referral and physical activity programme for survivors of prostate cancer) study established that a clinician referral and 12-week exercise training programme increased vigorous physical activity at 12 weeks among men with prostate cancer. Here, we report the 6- and 12-month outcomes. METHODS: In this multicentre cluster randomised controlled trial, we compared a clinician referral and exercise training programme to usual care...
February 7, 2017: Journal of Physical Activity & Health
https://www.readbyqxmd.com/read/28166777/associations-between-chronic-comorbidity-and-exacerbation-risk-in-primary-care-patients-with-copd
#4
Janine A M Westerik, Esther I Metting, Job F M van Boven, Waling Tiersma, Janwillem W H Kocks, Tjard R Schermer
BACKGROUND: COPD often coexists with chronic conditions that may influence disease prognosis. We investigated associations between chronic (co)morbidities and exacerbations in primary care COPD patients. METHOD: Retrospective cohort study based on 2012-2013 electronic health records from 179 Dutch general practices. Comorbidities from patients with physician-diagnosed COPD were categorized according to International Classification of Primary Care (ICPC) codes. Chi-squared tests, uni- and multivariable logistic, and Cox regression analyses were used to study associations with exacerbations, defined as oral corticosteroid prescriptions...
February 6, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28160360/using-cluster-analysis-of-anxiety-depression-to-identify-subgroups-of-prostate-cancer-patients-for-targeted-treatment-planning
#5
Christopher F Sharpley, Vicki Bitsika, Amelia K Warren, David R H Christie
OBJECTIVE: To explore any possible subgroupings of prostate cancer (PCa) patients based upon their combined anxiety-depression symptoms for the purposes of informing targeted treatments. METHODS: A sample of 119 prostate cancer patients completed the GAD7 (anxiety) and PHQ9 (depression), plus a background questionnaire, by mail survey. Data on the GAD7 and PHQ9 were used in a Cluster Analysis procedure to identify and define any cohesive subgroupings of patients within the sample...
February 3, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28152886/impact-of-precancer-multimorbidity-clusters-on-survival-and-functional-outcomes-after-cancer-in-older-patients
#6
Joshua Richman, Erin E Kent, Maria Pisu, Smita Bhatia
: 291 Background: While multimorbidity clustering is a significant problem in older adults, the impact of clusters present prior to cancer on post-diagnosis survival and function is unknown. We used SEER-Medicare Health Outcomes Survey data for 4583 cancer patients to address this research gap. METHODS: Patients with prostate (1741), breast (BC: 1345), colorectal (CRC: 904) and lung (593) cancer with pre- and post-diagnosis survey data were included. Surveys assessed comorbidity and activities of daily living (ADLs)...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28122812/psychological-distress-in-relation-to-site-specific-cancer-mortality-pooling-of-unpublished-data-from-16-prospective-cohort-studies
#7
G David Batty, Tom C Russ, Emmanuel Stamatakis, Mika Kivimäki
OBJECTIVE:  To examine the role of psychological distress (anxiety and depression) as a potential predictor of site specific cancer mortality. DESIGN:  Pooling of individual participant data from 16 prospective cohort studies initiated 1994-2008. SETTING:  Nationally representative samples drawn from the health survey for England (13 studies) and the Scottish health survey (three studies). PARTICIPANTS:  163 363 men and women aged 16 or older at study induction, who were initially free of a cancer diagnosis, provided self reported psychological distress scores (based on the general health questionnaire, GHQ-12) and consented to health record linkage...
January 25, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28093012/male-coping-through-a-long-term-cancer-trajectory-secondary-outcomes-from-a-rtc-examining-the-effect-of-a-multidisciplinary-rehabilitation-program-repca-among-radiated-men-with-prostate-cancer
#8
Karin B Dieperink, Christoffer Johansen, Steinbjørn Hansen, Lis Wagner, Klaus K Andersen, Lisbeth R Minet, Olfred Hansen
BACKGROUND: The objective of this study was to examine if rehabilitation influenced self-reported male coping styles during and up to three years after treatment with radiotherapy for prostate cancer. MATERIALS AND METHODS: In a single-center oncology unit in Odense, Denmark, 161 prostate cancer patients treated with radiotherapy and androgen deprivation therapy were included in a randomized controlled trial from 2010 to 2012. The trial examined the effect of a multidisciplinary rehabilitation program within six months of treatment consisting of two nursing counseling sessions and two instructive sessions with a physical therapist (n = 79), or standard care (n = 82)...
January 17, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28075176/the-adapp-trial-a-two-year-longitudinal-multidisciplinary-intervention-study-for-prostate-cancer-frail-patients-on-androgen-deprivation-associated-to-curative-radiotherapy
#9
Julie Mareschal, Kerstin Weber, Pascale Rigoli, Edmund Biason, Laura Frambati, Carole Gotteland, Thomas Zilli, Claude Pichard, Raymond Miralbell
BACKGROUND: Androgen deprivation (AD) therapy combined to radiotherapy (RT) is a curative therapeutic option for patients with non-metastatic locally advanced or aggressive intermediate prostate cancer (PC), though with a range of nutritional, physical, and psychological side effects. A multidisciplinary care program was created to help frail patients to prevent and manage those side effects. MATERIAL AND METHODS: We conducted a longitudinal interventional study in frail patients, presenting either cardiovascular/pulmonary comorbidities, old age (≥75 years), vulnerability ratings, or balance impairment...
January 11, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28045347/depression-treatment-among-elderly-medicare-beneficiaries-with-incident-cases-of-cancer-and-newly-diagnosed-depression
#10
Monira Alwhaibi, Suresh Madhavan, Thomas Bias, Kimberly Kelly, Jamie Walkup, Usha Sambamoorthi
OBJECTIVE: Depression treatment can improve the health outcomes of elderly cancer survivors. There is a paucity of studies on the extent to which depression is treated among elderly cancer survivors. Therefore, this study estimated the rates of depression treatment among elderly cancer survivors and identified the factors affecting depression treatment. METHODS: A retrospective cohort study design was adopted, and data were obtained from the linked Surveillance, Epidemiology and End Results (SEER) and Medicare database...
January 3, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/28040719/cancer-type-and-risk-of-newly-diagnosed-depression-among-elderly-medicare-beneficiaries-with-incident-breast-colorectal-and-prostate-cancers
#11
Monira Alwhaibi, Usha Sambamoorthi, Suresh Madhavan, Thomas Bias, Kimberly Kelly, James Walkup
BACKGROUND: Elderly individuals (age >65 years) with cancer are at high risk for newly diagnosed depression after a cancer diagnosis. It is not known whether the risk of newly diagnosed depression varies by cancer type. PURPOSE: To examine the variations in the risk of newly diagnosed depression by cancer type among elderly individuals with cancer. METHODS: This study used a retrospective cohort study design and data from the linked SEER-Medicare files...
January 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/28039542/the-relationships-between-spiritual-well-being-quality-of-life-and-psychological-factors-before-radiotherapy-for-prostate-cancer
#12
Sara J Walker, Yiyi Chen, Kyungjeen Paik, Brandy Mirly, Charles R Thomas, Arthur Y Hung
Given shifting trends of religious identities in the USA, better understanding the impact of patients' religious identities on health-related quality of life (QOL) may help tailor the use of psychological interventions. Men with prostate cancer (N = 43) completed measures of quality of life (QOL), spiritual well-being in two domains (i.e., Faith and Meaning/Peace), psychological state, and psychological trait before undergoing radiotherapy. We hypothesized that (1) higher existential Meaning/Peace would correlate with higher QOL and psychological trait protective factors (e...
December 30, 2016: Journal of Religion and Health
https://www.readbyqxmd.com/read/28027422/care-related-predictors-for-negative-intrusive-thoughts-after-prostate-cancer-diagnosis-data-from-the-prospective-lappro-trial
#13
Thordis Thorsteinsdottir, Heiddis Valdimarsdottir, Arna Hauksdottir, Johan Stranne, Ulrica Wilderäng, Eva Haglind, Gunnar Steineck
OBJECTIVE: Negative intrusive thoughts about one's prostate cancer have been associated with depressive mood and impaired quality of life among prostate cancer patients. However, little is known about possible predictors for negative intrusive thoughts among this group. We aimed to identify health- and care-related predictors for such thoughts among a population of men newly diagnosed with prostate cancer and undergoing radical prostatectomy. METHODS: In the LAPPRO-trial, 3154 men (80%) answered study-specific questionnaires at admission and three months after surgery...
December 27, 2016: Psycho-oncology
https://www.readbyqxmd.com/read/28024266/the-risk-of-being-depressed-is-significantly-higher-in-cancer-patients-than-in-the-general-population-prevalence-and-severity-of-depressive-symptoms-across-major-cancer-types
#14
T J Hartung, E Brähler, H Faller, M Härter, A Hinz, C Johansen, M Keller, U Koch, H Schulz, J Weis, A Mehnert
BACKGROUND: Depression is a common co-morbidity of cancer that has a detrimental effect on quality of life, treatment adherence and potentially survival. We conducted an epidemiological multi-center study including a population-based random comparison sample and estimated the prevalence of depressive symptoms by cancer site, thereby identifying cancer patients with the highest prevalence of depression. PATIENTS AND METHODS: We included 4020 adult cancer inpatients and outpatients from five distinct regions across Germany in a proportional stratified random sample based on the nationwide cancer incidence and a comparison group consisting of 5018 participants...
February 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28004451/total-depression-and-subtypes-in-prostate-cancer-survivors-10%C3%A2-years-after-treatment
#15
C F Sharpley, V Bitsika, D R H Christie, R Bradford, A Steigler, J W Denham
To describe the prevalence, severity and nature of depression in a sample of prostate cancer (PCa) survivors 10 years after diagnosis and treatment, 146 Australian patients from the RADAR trial who received their diagnosis 10 years previously completed the Zung Self-rating Depression Scale and a background questionnaire. Prevalence rates for clinically significant depression and severe depression were higher than those reported for the non-PCa men of the same age in Australia. The most common subtype of depression was Anhedonia, followed by Cognitive depression...
December 22, 2016: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28001303/predictors-of-multidomain-decline-in-health-related-quality-of-life-after-stereotactic-body-radiation-therapy-sbrt-for-prostate-cancer
#16
Robert T Dess, William C Jackson, Simeng Suy, Payal D Soni, Jae Y Lee, Ahmed E Abugharib, Zachary S Zumsteg, Felix Y Feng, Daniel A Hamstra, Sean P Collins, Daniel E Spratt
BACKGROUND: Stereotactic body radiation therapy (SBRT) for localized prostate cancer involves high-dose-per-fraction radiation treatments. Its use is increasing, but concerns remain about treatment-related toxicity. The authors assessed the incidence and predictors of a global decline in health-related quality of life (HRQOL) after prostate SBRT. METHODS: From 2008 to 2014, 713 consecutive men with localized prostate cancer received treatment with SBRT according to a prospective institutional protocol...
December 21, 2016: Cancer
https://www.readbyqxmd.com/read/27993906/effect-of-investigation-intensity-and-treatment-differences-on-prostate-cancer-survivor-s-physical-symptoms-psychological-well-being-and-health-related-quality-of-life-a-two-country-cross-sectional-study
#17
Anna T Gavin, David Donnelly, Conan Donnelly, Frances J Drummond, Eileen Morgan, Gerard J Gormley, Linda Sharp
AIM: To investigate effects on men's health and well-being of higher prostate cancer (PCa) investigation and treatment levels in similar populations. PARTICIPANTS: PCa survivors in Ireland where the Republic of Ireland (RoI) has a 50% higher PCa incidence than Northern Ireland (NI). METHOD: A cross-sectional postal questionnaire was sent to PCa survivors 2-18 years post-treatment, seeking information about current physical effects of treatment, health-related quality of life (HRQoL; EORTC QLQ-C30; EQ-5D-5L) and psychological well-being (21 question version of the Depression, Anxiety and Stress Scale, DASS-21)...
December 19, 2016: BMJ Open
https://www.readbyqxmd.com/read/27942251/the-effects-of-radical-prostatectomy-on-gay-and-bisexual-men-s-mental-health-sexual-identity-and-relationships-qualitative-results-from-the-restore-study
#18
B R Simon Rosser, Benjamin Capistrant, Beatriz Torres, Badrinath Konety, Enyinnaya Merengwa, Darryl Mitteldorf, William West
The effect of prostate cancer treatment in gay and bisexual men is an under-researched area. In 2015, we conducted in-depth telephone interviews with 19 gay and bisexual men who had undergone radical prostatectomies. Across the respondents' five emotional themes emerged: (1) shock at the diagnosis, (2) a reactive, self-reported "depression", (3) sex-specific situational anxiety, (4) a sense of grief, and, (5) an enduring loss of sexual confidence. Identity challenges included loss of a sense of maleness and manhood, changes in strength of sexual orientation, role-in-sex identity, and immersion into sexual sub-cultures...
2016: Sexual and Relationship Therapy: Journal of the British Association for Sexual and Relationship Therapy
https://www.readbyqxmd.com/read/27926950/c6-and-c7-substituted-3-4-dihydro-2-1h-quinolinones-as-inhibitors-of-monoamine-oxidase
#19
L Meiring, J Petzer, A Petzer
Purpose Monoamine oxidase (MAO) inhibitors are considered to be useful therapeutic agents and isoform specific inhibitors are employed for the treatment of depression and Parkinson's disease. MAO inhibitors are also under investigation for the treatment of disorders ranging from Alzheimer's disease, prostate cancer and certain cardiomyopathies. While a number of irreversible MAO inhibitors are available in the clinic, reversible inhibitors, particularly of the MAO-B isoform are still being developed. Based on our interest in discovering reversible inhibitors with specificity for MAO-B, we have recently reported that, among a series of 10 3,4-dihydro-2(1H)-quinolinone derivatives, are high potency MAO-B inhibitors, with a number of homologues displaying good selectivities for MAO-B over the MAO-A isoform...
December 7, 2016: Drug Research
https://www.readbyqxmd.com/read/27919958/dietary-flavonoids-luteolin-and-quercetin-suppressed-cancer-stem-cell-properties-and-metastatic-potential-of-isolated-prostate-cancer-cells
#20
Pei-Hsun Tsai, Chia-Hsiung Cheng, Chun-Yu Lin, Ying-Tang Huang, Lung-Ta Lee, Chithan C Kandaswami, Yo-Chuen Lin, Kevin Po-Hao Lee, Chin-Chun Hung, Jiuan-Jiuan Hwang, Ferng-Chun Ke, Geen-Dong Chang, Ming-Ting Lee
A highly invasive Du145-III subline was isolated by three successive passages of the parental Du145 prostate tumor cell line (Du145-P) through a Boyden chamber with matrigel-coated membrane support. Du145-III cells showed great invasion potential based on their increased ability to spread/migrate and enhanced expression/secretion of the matrix metalloproteinase 9 (MMP9). Du145-III cells exerted vasculogenic mimicry (VM) properties, reminiscent of endothelial cell characteristics and expressed elevated levels of cancer stem cell (CSC) markers, including Nanog, Sox2, CD44 and ABCG2 and ability to self-renew...
2016: Anticancer Research
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