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Prostate cancer and depression

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https://www.readbyqxmd.com/read/27919958/dietary-flavonoids-luteolin-and-quercetin-suppressed-cancer-stem-cell-properties-and-metastatic-potential-of-isolated-prostate-cancer-cells
#1
Pei-Hsun Tsai, Chia-Hsiung Cheng, Chun-Yu Lin, Ying-Tang Huang, Lung-Ta Lee, Chithan C Kandaswami, Yo-Chuen Lin, Kevin Po-Hao Lee, Chin-Chun Hung, Jiuan-Jiuan Hwang, Ferng-Chun Ke, Geen-Dong Chang, Ming-Ting Lee
A highly invasive Du145-III subline was isolated by three successive passages of the parental Du145 prostate tumor cell line (Du145-P) through a Boyden chamber with matrigel-coated membrane support. Du145-III cells showed great invasion potential based on their increased ability to spread/migrate and enhanced expression/secretion of the matrix metalloproteinase 9 (MMP9). Du145-III cells exerted vasculogenic mimicry (VM) properties, reminiscent of endothelial cell characteristics and expressed elevated levels of cancer stem cell (CSC) markers, including Nanog, Sox2, CD44 and ABCG2 and ability to self-renew...
December 2016: Anticancer Research
https://www.readbyqxmd.com/read/27916515/oestrogen-and-anti-androgen-therapy-for-transgender-women
#2
REVIEW
Vin Tangpricha, Martin den Heijer
Transgender women experience lifelong gender dysphoria due to a gender assignment at birth that is incongruent with their gender identity. They often seek hormone therapy, with or without surgery, to improve their gender dysphoria and to better align their physical and psychological features with a more feminine gender role. Some of the desired physical changes from oestrogen and anti-androgen therapy include decreased body and facial hair, decreased muscle mass, breast growth, and redistribution of fat. Overall the risks of treatment are low, but include thromboembolism, the risk of which depends on the dose and route of oestrogen administration...
December 1, 2016: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/27891701/depression-treatment-and-healthcare-expenditures-among-elderly-medicare-beneficiaries-with-newly-diagnosed-depression-and-incident-breast-colorectal-or-prostate-cancer
#3
Monira Alwhaibi, Usha Sambamoorthi, Suresh Madhavan, James T Walkup
OBJECTIVES: Depression is associated with high healthcare expenditures, and depression treatment may reduce healthcare expenditures. However, to date, there have not been any studies on the effect of depression treatment on healthcare expenditures among cancer survivors. Therefore, this study examined the association between depression treatment and healthcare expenditures among elderly with depression and incident cancer. METHODS: The current study utilized a retrospective longitudinal study design using the linked Surveillance, Epidemiology and End Results (SEER)-Medicare database...
November 28, 2016: Psycho-oncology
https://www.readbyqxmd.com/read/27886135/soy-and-health-update-evaluation-of-the-clinical-and-epidemiologic-literature
#4
REVIEW
Mark Messina
Soyfoods have long been recognized as sources of high-quality protein and healthful fat, but over the past 25 years these foods have been rigorously investigated for their role in chronic disease prevention and treatment. There is evidence, for example, that they reduce risk of coronary heart disease and breast and prostate cancer. In addition, soy alleviates hot flashes and may favorably affect renal function, alleviate depressive symptoms and improve skin health. Much of the focus on soyfoods is because they are uniquely-rich sources of isoflavones...
November 24, 2016: Nutrients
https://www.readbyqxmd.com/read/27881145/evaluation-of-efficacy-and-efficiency-of-a-pragmatic-intervention-by-a-social-worker-to-support-informal-caregivers-of-elderly-patients-the-ice-study-study-protocol-for-a-randomized-controlled-trial
#5
Astrid Pozet, Catherine Lejeune, Magalie Bonnet, Sandrine Dabakuyo, Michèle Dion, Philippe Fagnoni, Maryse Gaimard, Geneviève Imbert, Virginie Nerich, Audrey Foubert, Morgane Chotard, Marie Bonin, Amélie Anota, Franck Bonnetain
BACKGROUND: Medical progress and the lifestyle modification have prolonged life expectancy, despite the development of chronic diseases. Support and care for older subjects are often provided by a network of informal caregivers composed of family, friends and neighbors, who are essential in helping older persons to continue living at home. It has been shown that the extent and diversity of informal tasks may jeopardize the physical, mental and social wellbeing of caregivers. METHODS/DESIGN: The aim of the Informal Carers of Elderly cohort is to define, through a longitudinal study, profiles of caregivers of older patients with a diagnosis of one of the following diseases: cancer (breast, prostate, colorectal), neurodegenerative diseases (Parkinson's disease, Alzheimer's disease and similar diseases), neurovascular diseases (stroke), sensory diseases (age-related macular degeneration (AMD)) and heart disease (heart failure)...
November 3, 2016: Trials
https://www.readbyqxmd.com/read/27855360/benzyloxynitrostyrene-analogues-a-novel-class-of-selective-and-highly-potent-inhibitors-of-monoamine-oxidase-b
#6
Mietha M Van der Walt, Gisella Terre'Blanche, Jacobus P Petzer, Anél Petzer
This study examines a series of novel 3-benzyloxy-β-nitrostyrene analogues as a novel class of inhibitors of the monoamine oxidase (MAO) enzymes. MAO inhibitors are considered useful for the treatment of depression and Parkinson's disease, and have recently attracted attention as potential therapeutic agents for a range of disorders including Alzheimer's disease, prostate cancer and certain cardiomyopathies. This study shows that the 3-benzyloxy-β-nitrostyrene analogues are potent inhibitors of the MAO-B isoform with IC50 values in the nanomolar range (39-565 nM)...
November 9, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27843346/the-danish-prostate-cancer-database
#7
REVIEW
Mary Nguyen-Nielsen, Søren Høyer, Søren Friis, Steinbjørn Hansen, Klaus Brasso, Erik Breth Jakobsen, Mette Moe, Heidi Larsson, Mette Søgaard, Anne Nakano, Michael Borre
AIM OF DATABASE: The Danish Prostate Cancer Database (DAPROCAdata) is a nationwide clinical cancer database that has prospectively collected data on patients with incident prostate cancer in Denmark since February 2010. The overall aim of the DAPROCAdata is to improve the quality of prostate cancer care in Denmark by systematically collecting key clinical variables for the purposes of health care monitoring, quality improvement, and research. STUDY POPULATION: All Danish patients with histologically verified prostate cancer are included in the DAPROCAdata...
2016: Clinical Epidemiology
https://www.readbyqxmd.com/read/27810256/the-effect-of-an-online-support-group-on-patients-treatment-decisions-for-localized-prostate-cancer-an-online-survey
#8
Johannes Huber, Philipp Maatz, Tanja Muck, Bastian Keck, Hans-Christoph Friederich, Wolfgang Herzog, Andreas Ihrig
OBJECTIVE: To analyze the effect of an online support group (OSG) on the final treatment decision for localized prostate cancer. METHODS: We performed a cross-sectional descriptive study of the largest German prostate cancer OSG between July and October 2013. The online survey comprised 127 questions covering sociodemographic and disease-related information, decision-making habits, health-related quality of life, distress, depression, and anxiety. The primary outcome was to measure the effect of an OSG on the final treatment decision...
October 31, 2016: Urologic Oncology
https://www.readbyqxmd.com/read/27768127/fatigue-self-management-behaviors-in-patients-with-advanced-cancer-a-prospective-longitudinal-survey
#9
Raymond Chan, Patsy Yates, Alexandra L McCarthy
PURPOSE/OBJECTIVES: To explore the fatigue self-management behaviors and factors associated with effectiveness of these behaviors in patients with advanced cancer.
. DESIGN: Prospective longitudinal interviewer-administered survey.
. SETTING: Royal Brisbane and Women's Hospital in Queensland, Australia.
. SAMPLE: 152 outpatients with metastatic breast, lung, colorectal, and prostate cancer experiencing fatigue were recruited...
November 1, 2016: Oncology Nursing Forum
https://www.readbyqxmd.com/read/27688075/genome-wide-dna-methylation-in-1-year-old-infants-of-mothers-with-major-depressive-disorder
#10
Dante Cicchetti, Susan Hetzel, Fred A Rogosch, Elizabeth D Handley, Sheree L Toth
A genome-wide methylation study was conducted among a sample of 114 infants (M age = 13.2 months, SD = 1.08) of low-income urban women with (n = 73) and without (n = 41) major depressive disorder. The Illumina HumanMethylation450 BeadChip array with a GenomeStudio Methylation Module and Illumina Custom model were used to conduct differential methylation analyses. Using the 5.0 × 10-7 p value, 2,119 loci were found to be significantly different between infants of depressed and nondepressed mothers. Infants of depressed mothers had greater methylation at low methylation sites (0%-29%) compared to infants of nondepressed mothers...
November 2016: Development and Psychopathology
https://www.readbyqxmd.com/read/27672412/adverse-effects-and-safety-of-5-alpha-reductase-inhibitors-finasteride-dutasteride-a-systematic-review
#11
REVIEW
Jason M Hirshburg, Petra A Kelsey, Chelsea A Therrien, A Carlo Gavino, Jason S Reichenberg
Finasteride and dutasteride, both 5-alpha reductase inhibitors, are considered first-line treatment for androgenetic hair loss in men and used increasingly in women. In each case, patients are expected to take the medications indefinitely despite the lack of research regarding long-term adverse effects. Concerns regarding the adverse effects of these medications has led the United States National Institutes of Health to add a link for post-finasteride syndrome to its Genetic and Rare Disease Information Center...
July 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/27626365/patient-reported-outcomes-after-monitoring-surgery-or-radiotherapy-for-prostate-cancer
#12
Jenny L Donovan, Freddie C Hamdy, J Athene Lane, Malcolm Mason, Chris Metcalfe, Eleanor Walsh, Jane M Blazeby, Tim J Peters, Peter Holding, Susan Bonnington, Teresa Lennon, Lynne Bradshaw, Deborah Cooper, Phillipa Herbert, Joanne Howson, Amanda Jones, Norma Lyons, Elizabeth Salter, Pauline Thompson, Sarah Tidball, Jan Blaikie, Catherine Gray, Prasad Bollina, James Catto, Andrew Doble, Alan Doherty, David Gillatt, Roger Kockelbergh, Howard Kynaston, Alan Paul, Philip Powell, Stephen Prescott, Derek J Rosario, Edward Rowe, Michael Davis, Emma L Turner, Richard M Martin, David E Neal
Background Robust data on patient-reported outcome measures comparing treatments for clinically localized prostate cancer are lacking. We investigated the effects of active monitoring, radical prostatectomy, and radical radiotherapy with hormones on patient-reported outcomes. Methods We compared patient-reported outcomes among 1643 men in the Prostate Testing for Cancer and Treatment (ProtecT) trial who completed questionnaires before diagnosis, at 6 and 12 months after randomization, and annually thereafter...
October 13, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27569004/tetraiodothyroacetic-acid-and-transthyretin-silencing-inhibit-pro-metastatic-effect-of-l-thyroxin-in-anoikis-resistant-prostate-cancer-cells-through-regulation-of-mapk-erk-pathway
#13
Peng Zhang, Lifeng Chen, Yarong Song, Xuechao Li, Yadong Sun, Yajun Xiao, Yifei Xing
UNLABELLED: Prostate cancer is one of the most common malignancies in adult males and metastasis is the leading cause of death cases without satisfactory treatment options. Anoikis-resistance and migration are crucial aspects for the metastasis of various human cancer cells including prostate cancer and L-thyroxin (T4) has been proved to play vital roles in tumor metastasis. The present study demonstrated that T4 promoted migration and depressed detachment-induced apoptosis in anoikis-resistant prostate cancer cells while tetraiodothyroacetic acid (tetrac), a competitive antagonist of T4 at integrin αvβ3, reversed T4 induced effects through diminishing expressions of XIAP, MMP-2, VEGF together with inhibited activity of MAPK/ERK pathway...
October 1, 2016: Experimental Cell Research
https://www.readbyqxmd.com/read/27565902/long-term-consequences-of-finasteride-vs-placebo-in-the-prostate-cancer-prevention-trial
#14
Joseph M Unger, Cathee Till, Ian M Thompson, Catherine M Tangen, Phyllis J Goodman, Jason D Wright, William E Barlow, Scott D Ramsey, Lori M Minasian, Dawn L Hershman
BACKGROUND: Finasteride has been found to reduce the risk of low-grade prostate cancer but to have no impact on overall survival. The long-term adverse and beneficial consequences of finasteride have not been examined. METHODS: We used a linkage between data from the Prostate Cancer Prevention Trial (PCPT) and Medicare claims. Patients were examined by randomized study arm (finasteride vs placebo for 7 years) for long-term consequences of the intervention, including cardiac, endocrine, and sexual dysfunction, depression, diabetes, and benign prostatic hyperplasia (BPH)-related events...
December 2016: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/27541961/personality-and-psychological-distress-among-older-adult-long-term-cancer-survivors
#15
Gary T Deimling, Casey Albitz, Kara Monnin, Holly T Renzhofer Pappada, Elizabeth Nalepa, Melinda Laroco Boehm, Claire Mitchell
This research examines a model of how personality (Five-Factor Model) is related to adjustment to cancer in later life in terms of the presence of continuing cancer-related worry and depression among older adult, long-term cancer survivors. Data from an NCI-funded study with 275 older adult (age 60+), long-term (5+ years) survivors of breast, prostate, and colorectal cancer were examined. Regression analyses identified neuroticism as the strongest predictor of cancer-related worry along with continuing cancer-related symptoms...
August 19, 2016: Journal of Psychosocial Oncology
https://www.readbyqxmd.com/read/27536798/the-experience-of-adults-who-choose-watchful-waiting-or-active-surveillance-as-an-approach-to-medical-treatment-a-qualitative-systematic-review
#16
Leslie Rittenmeyer, Dolores Huffman, Michael Alagna, Ellen Moore
BACKGROUND: "Watchful waiting" or "active surveillance" is an alternative approach in the medical management of certain diseases. Most often considered appropriate as an approach to treatment for low-risk prostate cancer, it is also found in the literature in breast cancer surveillance, urinary lithiasis, lymphocytic leukemia, depression and small renal tumors. OBJECTIVES: This systematic review sought to:Identify and synthesize the best available international evidence on the experience of adults who choose watchful waiting or active surveillance as an approach to medical treatment...
February 2016: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/27530156/nurse-led-group-consultation-intervention-reduces-depressive-symptoms-in-men-with-localised-prostate-cancer-a-cluster-randomised-controlled-trial
#17
Penelope Schofield, Karla Gough, Kerryann Lotfi-Jam, Rebecca Bergin, Anna Ugalde, Paul Dudgeon, Wallace Crellin, Kathryn Schubach, Farshard Foroudi, Keen Hun Tai, Gillian Duchesne, Rob Sanson-Fisher, Sanchia Aranda
BACKGROUND: Radiotherapy for localised prostate cancer has many known and distressing side effects. The efficacy of group interventions for reducing psychological morbidity is lacking. This study investigated the relative benefits of a group nurse-led intervention on psychological morbidity, unmet needs, treatment-related concerns and prostate cancer-specific quality of life in men receiving curative intent radiotherapy for prostate cancer. METHODS: This phase III, two-arm cluster randomised controlled trial included 331 men (consent rate: 72 %; attrition: 5 %) randomised to the intervention (n = 166) or usual care (n = 165)...
2016: BMC Cancer
https://www.readbyqxmd.com/read/27497762/impact-of-enzalutamide-compared-with-bicalutamide-on-quality-of-life-in-men-with-metastatic-castration-resistant-prostate-cancer-additional-analyses-from-the-terrain-randomised-clinical-trial
#18
Axel Heidenreich, Simon Chowdhury, Laurence Klotz, David Robert Siemens, Arnauld Villers, Cristina Ivanescu, Stefan Holmstrom, Benoit Baron, Fong Wang, Ping Lin, Neal D Shore
BACKGROUND: Improving health-related quality of life (HRQoL) is an important goal in metastatic castration-resistant prostate cancer (mCRPC). OBJECTIVE: To examine the impact of enzalutamide versus bicalutamide on HRQoL in mCRPC. DESIGN, SETTING, AND PARTICIPANTS: TERRAIN is a multinational, phase 2, randomised, double-blind study in asymptomatic/mildly symptomatic men with mCRPC (ClinicalTrials.gov, NCT01288911). Patients were randomised (1:1) via an interactive voice and web response system to enzalutamide 160mg/d (n=184) or bicalutamide 50mg/d (n=191), with androgen deprivation therapy...
August 3, 2016: European Urology
https://www.readbyqxmd.com/read/27485119/quality-of-life-effects-of-androgen-deprivation-therapy-in-a-prostate-cancer-cohort-in-new-zealand-can-we-minimize-effects-using-a-stratification-based-on-the-aldo-keto-reductase-family-1-member-c3-rs12529-gene-polymorphism
#19
Nishi Karunasinghe, Yifei Zhu, Dug Yeo Han, Katja Lange, Shuotun Zhu, Alice Wang, Stephanie Ellett, Jonathan Masters, Megan Goudie, Justin Keogh, Benji Benjamin, Michael Holmes, Lynnette R Ferguson
BACKGROUND: Androgen deprivation therapy (ADT) is an effective palliation treatment in men with advanced prostate cancer (PC). However, ADT has well documented side effects that could alter the patient's health-related quality of life (HRQoL). The current study aims to test whether a genetic stratification could provide better knowledge for optimising ADT options to minimize HRQoL effects. METHODS: A cohort of 206 PC survivors (75 treated with and 131 without ADT) was recruited with written consent to collect patient characteristics, clinical data and HRQoL data related to PC management...
2016: BMC Urology
https://www.readbyqxmd.com/read/27469939/associations-of-objectively-measured-moderate-to-vigorous-physical-activity-and-sedentary-behavior-with-quality-of-life-and-psychological-well-being-in-prostate-cancer-survivors
#20
Cadeyrn J Gaskin, Melinda Craike, Mohammadreza Mohebbi, Jo Salmon, Kerry S Courneya, Suzanne Broadbent, Patricia M Livingston
PURPOSE: Although evidence is building on the positive effects of physical activity for prostate cancer survivors, less is known about the possible independent effects of sedentary behavior on quality of life and psychological well-being in this population. We determined the extent to which objectively measured moderate-to-vigorous physical activity (MVPA) and sedentary behavior were independently associated with quality of life, anxiety, and depressive symptoms in prostate cancer survivors...
September 2016: Cancer Causes & Control: CCC
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