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Prostate cancer and depression

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https://www.readbyqxmd.com/read/28921733/effects-of-individual-and-partner-factors-on-anxiety-and-depression-in-taiwanese-prostate-cancer-patients-a-longitudinal-study
#1
C H Chien, C K Chuang, K L Liu, C T Wu, S T Pang, P K Tsay, Y H Chang, X Y Huang, H E Liu
Studies exploring the mediating and predictive factors of anxiety and depression for prostate cancer patients in Eastern countries are scant. Guided by the transactional model of stress and coping, this study determined the predictors and mediators of anxiety and depression in prostate cancer patients. The participants comprised 115 prostate cancer patients and 91 partners. The patients and partners completed questionnaires regarding physical symptoms, disease appraisals, coping behaviours, anxiety and depression in the period before confirmation of treatment decisions and 1, 3, 6 and 12 months after treatment...
September 18, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28887095/psychological-distress-in-patients-undergoing-surgery-for-urological-cancer-a-single-centre-cross-sectional-study
#2
Antonio Luigi Pastore, Ana Mir, Serena Maruccia, Giovanni Palleschi, Antonio Carbone, Cristina Lopez, Nuria Camps, Joan Palou
PURPOSE: Interest in the disease-specific psychological well-being of patients with cancer has increased, and it has been estimated that less than half of all patients with cancer are properly identified and subsequently treated for anxiety or depression. The aim of this study is to evaluate psychological distress in uro-oncological patients undergoing different surgeries: radical cystectomy, radical prostatectomy, radical nephrectomy, or transurethral resection (TUR) before the surgery...
September 5, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28881501/drug-drug-interaction-potential-in-men-treated-with-enzalutamide-mind-the-gap
#3
G E Benoist, I M van Oort, S Smeenk, A Javad, D M Somford, D M Burger, N Mehra, N P van Erp
AIM: Metastatic castration resistant prostate cancer (mCRPC) patients are generally older patients with several co-morbidities and are therefore more at risk for complications due to drug-drug interactions(DDIs). We assessed the prevalence of potential DDIs in a cohort of mCRPC patients treated with enzalutamide. METHODS: We conducted a retrospective review of pharmacy records to retrieve individual drug histories of mCRPC patients who started enzalutamide therapy in a tertiary care setting...
September 7, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28866631/association-of-gender-specific-risk-factors-in-metabolic-and-cardiovascular-diseases-an-nhanes-based-cross-sectional-study
#4
Xiu-E Zhang, Bei Cheng, Qian Wang, Jing-Jing Wan
In the present cross-sectional study, based on National Health and Nutrition Examination Survey (NHANES, 2007-2010) cohorts, various risk factors for metabolic syndrome (MetS) and cardiovascular diseases (CVDs) were analyzed (n=12,153). The variables analyzed include, demographics, comorbidities associated with MetS or CVD, behavioral and dietary factors, while the primary endpoints were the prevalence of MetS and CVD. The prevalence of MetS and CVD was slightly higher in males as compared with females (42...
September 2, 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/28861845/face-to-face-vs-online-peer-support-groups-for-prostate-cancer-a-cross-sectional-comparison-study
#5
Johannes Huber, Tanja Muck, Philipp Maatz, Bastian Keck, Paul Enders, Imad Maatouk, Andreas Ihrig
BACKGROUND: As social media are evolving rapidly online support groups (OSG) are becoming increasingly important for patients. Therefore, the aim of our study was to compare the users of traditional face-to-face support groups and OSG. PATIENTS AND METHODS: We performed a cross-sectional comparison study of all regional face-to-face support groups and the largest OSG in Germany. By applying validated instruments, the survey covered sociodemographic and disease-related information, decision-making habits, psychological aspects, and quality of life...
August 31, 2017: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/28859204/-physical-activity-and-cancer
#6
Stephanie Krebs, Anika Berling-Ernst, Martin Halle
The value of physical activity in cancer prevention and therapy has been increasingly recognised during the last twenty years. Many patients suffer from a loss of physical performance and a decline in quality of life - with fatigue, anxiety and depression as a direct result of their disease and therapy. Since the 1990 s, there has been a substantial increase in scientific evidence demonstrating the positive effects of physical activity in cancer patients. This article presents an overview of the most important studies investigating the effects of physical activity for breast, colon, and prostate cancer...
August 31, 2017: Sportverletzung Sportschaden: Organ der Gesellschaft Für Orthopädisch-Traumatologische Sportmedizin
https://www.readbyqxmd.com/read/28857340/associations-between-reduced-telomere-length-depressed-mood-anhedonia-and-irritability-in-prostate-cancer-patients-further-evidence-for-the-presence-of-male-depression
#7
Christopher F Sharpley, David R H Christie, Vicki Bitsika, Linda L Agnew, Nicholas M Andronicos, Mary E McMillan
No abstract text is available yet for this article.
August 30, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28814281/impact-of-new-generation-hormone-therapy-on-cognitive-function-in-elderly-patients-treated-for-a-metastatic-prostate-cancer-cog-pro-trial-protocol
#8
Marie Lange, Heidi Laviec, Hélène Castel, Natacha Heutte, Alexandra Leconte, Isabelle Léger, Bénédicte Giffard, Aurélie Capel, Martine Dubois, Bénédicte Clarisse, Elodie Coquan, Frédéric Di Fiore, Sophie Gouérant, Philippe Bartélémy, Laure Pierard, Karim Fizazi, Florence Joly
BACKGROUND: New generation hormone-therapies (NGHT) targeting the androgen signalling pathway are nowadays proposed to elderly patients with metastatic castration-resistant prostate cancer (CRPCa). The impact of these treatments on cognitive function has never been evaluated whereas cognitive impairment may have an impact on the autonomy and the treatment adherence. The aim of this study is to prospectively assess the incidence of cognitive impairment in elderly men after treatment by NGHT for a metastatic CRPCa...
August 16, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28803700/association-of-androgen-deprivation-therapy-and-depression-in-the-treatment-of-prostate-cancer-a-systematic-review-and-meta-analysis
#9
Kevin T Nead, Sumi Sinha, David D Yang, Paul L Nguyen
BACKGROUND: There is increasing evidence that androgen deprivation therapy (ADT) may be associated with depression. Existing studies have shown conflicting results. METHODS: PubMed, Web of Science, Embase, and PsycINFO were queried on April 5, 2017. Eligible studies were in English and reported depression among individuals with prostate cancer exposed to a course of ADT vs. a lesser-exposed group (e.g., any-ADT vs. no ADT and continuous ADT vs. intermittent ADT)...
August 10, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28797855/exploring-genetic-attributions-underlying-radiotherapy-induced-fatigue-in-prostate-cancer-patients
#10
Sepehr Hashemi, Juan Luis Fernandez Martinez, Leorey Saligan, Stephen Sonis
CONTEXT: Despite numerous proposed mechanisms, no definitive pathophysiology underlying Radiotherapy-Induced Fatigue (RIF) has been established. However, the dysregulation of a set of 35 genes was recently validated to predict development of fatigue in prostate cancer patients (PCP's) receiving radiotherapy. OBJECTIVES: To hypothesize novel pathways, and provide genetic targets for currently proposed pathways implicated in RIF development through analysis of the previously validated gene set...
August 7, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28774788/does-psychological-resilience-buffer-against-the-link-between-the-5-httlpr-polymorphism-and-depression-following-stress
#11
Christopher F Sharpley, David R H Christie, Vicki Bitsika, Nicholas M Andronicos, Linda L Agnew, Mary E McMillan
The comparative strength of the 5-HTTLPR polymorphism as a 'predictor' of depression after major stress, versus the 'protective' effect of psychological resilience (PR) against depression after major stress, was tested in a homogeneous sample of older men who had all received a diagnosis and treatment for prostate cancer. Results supported the association between PR and lower depression after stress, but did not support the association between the 5-HTTLPR and elevated depression after stress. Examination of PR at scale, factor, and item level identified the specific PR-related behaviour that was the most powerful predictor of low depression...
July 31, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28752333/significance-of-long-chain-polyunsaturated-fatty-acids-in-human-health
#12
REVIEW
Rafael Zárate, Nabil El Jaber-Vazdekis, Noemi Tejera, José A Pérez, Covadonga Rodríguez
In the last decades, the development of new technologies applied to lipidomics has revitalized the analysis of lipid profile alterations and the understanding of the underlying molecular mechanisms of lipid metabolism, together with their involvement in the occurrence of human disease. Of particular interest is the study of omega-3 and omega-6 long chain polyunsaturated fatty acids (LC-PUFAs), notably EPA (eicosapentaenoic acid, 20:5n-3), DHA (docosahexaenoic acid, 22:6n-3), and ARA (arachidonic acid, 20:4n-6), and their transformation into bioactive lipid mediators...
December 2017: Clinical and Translational Medicine
https://www.readbyqxmd.com/read/28731489/sexual-health-adherence-to-mediterranean-diet-body-weight-physical-activity-and-mental-state-factors-correlated-to-each-other
#13
Pier A Della Camera, Simone Morselli, Gianmartin Cito, Giovanni Tasso, Andrea Cocci, Nicola Laruccia, Fabrizio Travaglini, Dario Del Fabbro, Antonio R Mottola, Mauro Gacci, Sergio Serni, Marco Carini, Alessandro Natali
INTRODUCTION: Mediterranean diet has shown a protective role against cardiovascular disease, diabetes, cancer onset, microvascular damage and dementia in many trials. Our purpose is the assessment of a correlation between physical activity, Mediterranean diet, body mass index (BMI), depression and erection disorder (ED). METHODS: After having signed disclaimer to the study participation, we administered the IIEF 15 questionnaire (International Index of Erectil Function), the Hamilton questionnaire for major depression, the Med-Diet Questionnaire, the Ipaq Questionnaire (International Index of Physical Activity) to 245 patients and calculated the BMI...
July 14, 2017: Urologia
https://www.readbyqxmd.com/read/28723375/the-effects-of-exercise-on-fatigue-quality-of-life-and-psychological-function-for-men-with-prostate-cancer-systematic-review-and-meta-analyses
#14
REVIEW
Vishal Vashistha, Balwinder Singh, Sukhdeep Kaur, Larry J Prokop, Dharam Kaushik
CONTEXT: Conflicting data exists on the role of exercise interventions in patients with prostate cancer (PCa) regarding quality of life (QOL) endpoints. OBJECTIVE: To evaluate the effects of exercise interventions on fatigue, QOL, depression, and anxiety in PCa patients. EVIDENCE ACQUISITION: We searched seven major databases (MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, Web of Science, and Scopus) for randomized control trials (RCTs) of supervised exercise interventions for men with PCa from database inception to October 2015...
August 2016: European Urology Focus
https://www.readbyqxmd.com/read/28711461/prevalence-of-comorbidities-in-rheumatoid-arthritis-and-evaluation-of-their-monitoring-in-clinical-practice-the-spanish-cohort-of-the-comora-study
#15
Alejandro Balsa, Leticia Lojo-Oliveira, Mercedes Alperi-López, María García-Manrique, Carmen Ordóñez-Cañizares, Lorena Pérez, Virginia Ruiz-Esquide, Alfonso Corrales, Javier Narváez, José Rey-Rey, Carlos Rodríguez-Lozano, Soledad Ojeda, Santiago Muñoz-Fernández, Joan M Nolla, José García-Torrón, Fernando Gamero, Rosario García-Vicuña, Blanca Hernández-Cruz, José Campos, José Rosas, José Francisco García-Llorente, Antonio Gómez-Centeno, Rafael Cáliz, Raimon Sanmartí, Alberto Bermúdez, Lydia Abasolo-Alcázar, Antonio Fernández-Nebro, Luis Rodríguez-Rodríguez, Carlos Marras, Miguel Ángel González-Gay, Ihsane Hmamouchi, Emilio Martín-Mola
OBJECTIVES: To describe the prevalence of comorbidities in patients with RA in Spain and discuss their management and implications using data from the Spanish cohort of the multinational study on COMOrbidities in Rheumatoid Arthritis (COMORA). METHODS: This is a national sub-analysis of the COMORA study. We studied the demographics and disease characteristics of 200 adults patients diagnosed with RA (1987 ACR), and routine practices for screening and preventing the following selected comorbidities: cardiovascular, infections, cancer, gastrointestinal, pulmonary, osteoporosis and depression...
July 12, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28701750/prognostic-significance-of-the-digit-ratio-after-hormone-therapy-for-prostate-cancer-a-prospective-multicenter-study
#16
Guanjian Li, Ke Sun, Jie Guo, Shixing Li, Bo Li, Jing Cao, Pengfei Lu, Jiajia Yang, Ying Zhang, Xin Yang, Le Gao, Yi He, Tao Cui, Bin Ma
The digit ratio has been used as a retrospective noninvasive biomarker to investigate the putative effects of prenatal exposure to androgens. In recent years, many scholars have paid attention to the association between 2D:4D (the second and fourth digits) and prostatic cancer. This study explored the prognostic significance of digit ratio in prostate cancer patients. We reviewed the progressive status and survival of 382 prostate cancer patients who had received hormone therapy at our institutions. Survival of clinicopathological variables analyzed as categorical variables were determined by the log-rank test...
July 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28693878/depression-and-health-related-quality-of-life-and-their-association-with-resourcefulness-in-survivors-of-prostate-cancer
#17
Hung-Yu Lin, Hui-Ling Lai, Chun-I Chen, Chiung-Yu Huang
OBJECTIVE: This study aimed to identify the determinants of depressive symptoms (DSs) and health-related quality of life (HRQOL) in survivors of prostate cancer (PC). METHODS: This study used a descriptive, correlational design to assess a sample of 133 individuals with PC. The participants were face-to-face interviewed to collect demographic data and disease characteristics, assess self-control schedule, and survey health status. Correlation analysis, Student's t-test, ANOVA, and regression analysis were applied...
August 2017: Archives of Psychiatric Nursing
https://www.readbyqxmd.com/read/28692205/limitations-in-the-inverse-association-between-psychological-resilience-and-depression-in-prostate-cancer-patients-experiencing-chronic-physiological-stress
#18
Christopher F Sharpley, David R H Christie, Vicki Bitsika, Linda L Agnew, Nicholas M Andronicos, Mary E McMillan, Timothy M Richards
OBJECTIVE: To investigate the effect of chronic stress as measured in cortisol concentrations upon the association between Psychological Resilience (PR) and depression in prostate cancer (PCa) patients. METHODS: 104 men with PCa completed inventories on PR, depression and background factors, plus gave a sample of their saliva for cortisol assay. RESULTS: The inverse correlation between PR and depression was present only for PCa patients with low or moderate concentrations of salivary cortisol (when classified as more than 1...
July 10, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28687876/chromosome-21-encoded-micrornas-mrnas-impact-on-down-s-syndrome-and-trisomy-21-linked-disease
#19
P N Alexandrov, M E Percy, Walter J Lukiw
Down's syndrome (DS; also known as trisomy 21; T21) is caused by a triplication of all or part of human chromosome 21 (chr21). DS is the most common genetic cause of intellectual disability attributable to a naturally-occurring imbalance in gene dosage. DS incurs huge medical, healthcare, and socioeconomic costs, and there are as yet no effective treatments for this incapacitating human neurogenetic disorder. There is a remarkably wide variability in the 'phenotypic spectrum' associated with DS; the progression of symptoms and the age of DS onset fluctuate, and there is further variability in the biophysical nature of the chr21 duplication...
July 7, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/28685499/body-image-mediates-the-effect-of-cancer-related-stigmatization-on-depression-a-new-target-for-intervention
#20
Peter Esser, Anja Mehnert, Christoffer Johansen, Beate Hornemann, Andreas Dietz, Jochen Ernst
OBJECTIVE: Since cancer-related stigmatization is prevalent but difficult to change, research on its impact on psychological burden and intervening variables is needed. Therefore, we investigated the effect of stigmatization on depressive symptomatology and whether body image mediates this relationship. METHODS: This bi-centric study assessed patients of four major tumor entities. We measured stigmatization (SIS-D), depressive symptomatology (PHQ-9) and body image (FKB-20)...
July 6, 2017: Psycho-oncology
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