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Cerebrovascular disease

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https://www.readbyqxmd.com/read/29909404/aortic-arch-width-and-cardiovascular-disease-in-men-and-women-in-the-community
#1
Michael L Chuang, Philimon N Gona, Saadia Qazi, Rebecca M Musgrave, Caroline S Fox, Joseph M Massaro, Udo Hoffmann, Christopher J O'Donnell
BACKGROUND: We sought to determine whether increased aortic arch width (AAW) adds to standard Framingham risk factors and coronary artery calcium (CAC) for prediction of incident adverse cardiovascular disease (CVD) events in community-dwelling adults. METHODS AND RESULTS: A total of 3026 Framingham Heart Study Offspring and Third Generation cohort participants underwent noncontrast multidetector computed tomography from 2002 to 2005 to quantify CAC. We measured AAW as the distance between the centroids of the ascending and descending thoracic aorta, at the level of main pulmonary artery bifurcation or the right pulmonary artery...
June 16, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29908618/hormonal-management-for-transfeminine-individuals
#2
REVIEW
Jessica Abramowitz, Vin Tangpricha
Transfeminine individuals are treated with estradiol and anti-androgen agents to transition to a more feminine appearance. The physical changes that occur with estradiol therapy include breast development, body fat redistribution, and decreased muscle mass. Transfeminine treatment regimens require monitoring and dose adjustments to achieve appropriate physiologic targets to enhance feminization and decrease risk of adverse outcomes. Adverse effects associated with estradiol use include thromboembolic disease, macroprolactinoma, breast cancer, coronary artery disease, cerebrovascular disease, cholelithiasis, and hypertriglyceridemia...
July 2018: Clinics in Plastic Surgery
https://www.readbyqxmd.com/read/29907385/long-term-changes-in-cerebrovascular-reactivity-following-ec-ic-bypass-for-intracranial-steno-occlusive-disease
#3
Casey Rosen, Larissa McKetton, Jeremy Russell, Kevin Sam, Julien Poublanc, Adrian Crawley, Jay S Han, Olivia Sobczyk, James Duffin, Danny M Mandell, Michael Tymianski, Joseph A Fisher, David J Mikulis, Lashmi Venkatraghavan
The purpose of this retrospective observational study is to investigate the long-term changes in cerebrovascular reactivity (CVR) as a measure of cerebral hemodynamics in patients with intracranial steno-occlusive disease (IC-SOD) after they have undergone an Extracranial-intracranial (EC-IC) bypass. Twenty-six patients suffering from IC-SOD were selected from our CVR database. Nineteen patients underwent unilateral and 7 underwent bilateral revascularization. CVR measurements were done using BOLD-MRI and precisely controlled CO2 and expressed as ΔBOLD (%)/Δ PET CO2 (mmHg)...
June 12, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29907231/socioeconomics-affecting-quality-outcomes-in-asian-trauma-patients-within-the-united-states
#4
Krista L Haines, Suresh Agarwal, Hee Soo Jung
INTRODUCTION: Asian-Americans and Pacific Islanders are often considered as a uniform group when examining race in health outcomes. However, the generally favorable economic outcomes in this group belie significant socioeconomic variance between its heterogeneous subgroups. This study evaluates the impact of socioeconomic status on the health outcomes of Asian trauma patients. METHODS: From 2012 to 2015, 52,704 Asians who presented to trauma centers were registered with the National Trauma Data Bank with known disposition...
August 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29906583/prevalence-incidence-co-morbidity-and-mortality-rates-of-ossification-of-posterior-longitudinal-ligament-opll-in-the-cervical-spine-a-nested-case-control-cohort-study
#5
Bong Ju Moon, Sun Kyu Choi, Dong Ah Shin, Seong Yi, Keung Nyun Kim, Do Heum Yoon, Yoon Ha
OBJECT: To evaluate the prevalence, incidence, morbidity, and mortality rates of cervical ossification of posterior longitudinal ligament (OPLL), using data from a 12-year national cohort of 1,025,340 Korean people. METHODS: A nested case-control cohort study was performed using the insurance claims database, during 2002 to 2013, provided by the National Health Insurance Service. We examined the prevalence and incidence of cervical OPLL. Age/sex-matched controls were randomly extracted, with 10 times the number of OPLL cases...
June 12, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29906534/anti-inflammatory-effect-of-low-molecular-weight-fucoidan-from-saccharina-japonica-on-atherosclerosis-in-apoe-knockout-mice
#6
Yingjie Xu, Jie Xu, Keli Ge, Qingwu Tian, Peng Zhao, Yunliang Guo
Atherosclerosis (AS) is the key cause of many cardiovascular and cerebrovascular diseases. The inflammatory response and lipid metabolism disorders contribute to the development and progression of AS. This work aims to study the anti-inflammatory effect and mechanism of low molecular weight fucoidan (LMWF) obtained from Saccharina japonica on atherosclerosis in apoE-knockout mice. The experimental results showed that LMWF statistically decreased the levels of triglyceride (TRIG) and oxidative low-density lipoproteins (ox-LDL) and stabilized established atherosclerotic lesions...
June 12, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29905566/-evaluation-of-neuroprotective-activity-of-complex-impact-of-magnesium-of-sulfate-lamotrygine-and-n-acetylcysteine-under-conditions-of-combined-normobaric-hypoxia-with-ligation-of-right-carotid-artery-in-rats
#7
M Samsonia, M Kandelaki, N Baratashvili
Cerebrovascular diseases of ischemic origin still remain the leading cause of death and disability of the population. In acute cerebral discirculation conditions, anaerobic glycolysis is activated, ATP formation rate decreases, the ion pumps work is disrupted and superoxide radicals are formed. Eventually, ionic asymmetry leads to the cytotoxic and vasogenic brain edema. Therefore, it is extremely important to induce simultaneous (complex) effect of medications on the key mechanisms of neuronal damage in process of survival of brain cells during acute ischemic stroke...
May 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29904830/migraine-and-cerebrovascular-disease-still-a-dangerous-connection
#8
Elio Clemente Agostoni, Marco Longoni
Migraine is a common type of headache in young adults, with an estimated prevalence of 4% before puberty and as high as 25% in women by their mid to late 30s. About one third of migraineurs experience transient neurological symptoms known as auras, which characterize a variant known as migraine with aura. Many evidences have shown an increased risk of vascular events in patients affected by migraine, particularly among women and among migraine patients with aura. Potential underlying mechanisms include endothelial dysfunction, hypercoagulability, platelet aggregation, vasospasm, cardiovascular risk factors, paradoxical embolism, spreading depolarization, shared genetic risk, use of non-steroidal anti-inflammatory drugs, and immobilization...
June 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29904448/extended-duration-dual-antiplatelet-therapy-after-percutaneous-coronary-intervention-in-patients-with-peripheral-arterial-disease-a-meta-analysis
#9
Hua Ling, Ebony Andrews, David Ombengi, Fang Li
Background: Patients with peripheral arterial disease (PAD) undergoing percutaneous coronary intervention (PCI) are at elevated risk of ischemic and bleeding events. However, the optimal duration of dual antiplatelet therapy (DAPT) after PCI in patients with PAD remains unclear. Methods: A systematic literature search was performed through June 2017 using PubMed, EMBASE and Cochrane databases with the following key terms: "dual antiplatelet therapy", "P2Y12 inhibitor", "myocardial infarction", "percutaneous coronary intervention", "stent", "peripheral arterial disease", and "ankle-brachial index"...
June 2018: Cardiology Research
https://www.readbyqxmd.com/read/29904334/sleep-disorders-associated-with-alzheimer-s-disease-a-perspective
#10
REVIEW
Anna Brzecka, Jerzy Leszek, Ghulam Md Ashraf, Maria Ejma, Marco F Ávila-Rodriguez, Nagendra S Yarla, Vadim V Tarasov, Vladimir N Chubarev, Anna N Samsonova, George E Barreto, Gjumrakch Aliev
Sleep disturbances, as well as sleep-wake rhythm disturbances, are typical symptoms of Alzheimer's disease (AD) that may precede the other clinical signs of this neurodegenerative disease. Here, we describe clinical features of sleep disorders in AD and the relation between sleep disorders and both cognitive impairment and poor prognosis of the disease. There are difficulties of the diagnosis of sleep disorders based on sleep questionnaires, polysomnography or actigraphy in the AD patients. Typical disturbances of the neurophysiological sleep architecture in the course of the AD include deep sleep and paradoxical sleep deprivation...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29904053/naoxintong-capsules-inhibit-the-development-of-diabetic-nephropathy-in-db-db-mice
#11
Shu Yang, Mengyang Liu, Yuanli Chen, Chuanrui Ma, Lipei Liu, Buchang Zhao, Yong Wang, Xiaoju Li, Yan Zhu, Xiumei Gao, Deling Kong, Yajun Duan, Jihong Han, Xiaoxiao Yang
NaoXinTong Capsule (NXT), a Chinese medicine, is currently used to treat patients with cardiovascular and cerebrovascular diseases. Clinical observations indicate its anti-diabetic functions with unclear mechanisms. Herein, we report the effect of NXT on diabetic nephropathy (DN). Type 2 diabetic db/db mice were treated with NXT for 14 weeks. In the course of treatment, NXT reduced diabetes-increased glucose levels and improved renal functions. At the end of treatment, we found that NXT ameliorated serum lipid profiles and other biochemical parameters...
June 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29903685/periodontal-disease-systemic-inflammation-and-the-risk-of-cardiovascular-disease
#12
REVIEW
Edgar Francisco Carrizales-Sepúlveda, Alejandro Ordaz-Farías, Raymundo Vera-Pineda, Ramiro Flores-Ramírez
Periodontal and cardiovascular disease are both major health issues. Poor oral health has long been associated with the development of systemic diseases, with the typical example being the risk of endocarditis posterior to dental procedures. Through the years, the association of periodontal disease with other non-infectious systemic diseases has been brought to attention. One of the most interesting associations is the one that exists with the development of cardiovascular disease. Many studies, including systematic reviews and meta-analyses, suggest an important association between periodontal disease and ischaemic heart disease, cerebrovascular disease, heart failure, atrial fibrillation and peripheral artery disease...
June 2, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29903684/environment-cancer-and-inequalities-the-urgent-need-for-prevention
#13
REVIEW
Paolo Vineis, Daniela Fecht
The proportion of total deaths attributable to environmental factors is estimated to be 23% of global deaths and 22% of global disability-adjusted life years (DALYs) according to one review. These estimates encompass all environmental agents including infectious agents but excluding behavioural factors. The authors of the review also estimated that 16% (95% CI: 7-41%) of cancer deaths are attributable to environmental risk factors (and 36% [95% CI: 17-52%] for lung cancer). In this article, we focus on the reasons why epidemiology is often unable to account for the whole burden of environmental carcinogens...
June 11, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29903615/neurotransmitter-modulation-by-the-gut-microbiota
#14
Philip Strandwitz
The gut microbiota - the trillions of bacteria that reside within the gastrointestinal tract - has been found to not only be an essential component immune and metabolic health, but also seems to influence development and diseases of the enteric and central nervous system, including motility disorders, behavioral disorders, neurodegenerative disease, cerebrovascular accidents, and neuroimmune-mediated disorders. By leveraging animal models, several different pathways of communication have been identified along the "gut-brain-axis" including those driven by the immune system, the vagus nerve, or by modulation of neuroactive compounds by the microbiota...
August 15, 2018: Brain Research
https://www.readbyqxmd.com/read/29902313/association-of-cardiovascular-comorbidities-with-hearing-loss-in-the-older-old
#15
Kapil Wattamwar, Z Jason Qian, Jenna Otter, Matthew J Leskowitz, Francesco F Caruana, Barbara Siedlecki, Jaclyn B Spitzer, Anil K Lalwani
Importance: In the United States, the population of individuals older than 80 years is expected to double in the next 40 years. Cardiovascular comorbidities are prevalent in this older old population, and their relationship with hearing loss has not been well characterized. Objective: To investigate the association of cardiovascular disease (CVD)-related risk factors with auditory function among the older old (>80 years). Design, Setting, and Participants: Audiological data and medical records from 2001 through 2014 of 433 patients aged 80 to 106 years at an academic medical center were analyzed in 2017...
June 14, 2018: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29901637/extracranial-intracranial-bypass-in-medial-sphenoid-ridge-meningioma-associated-with-severe-stenosis-of-the-intracranial-segments-of-the-internal-carotid-artery-a-case-report
#16
Yabo Huang, Zhong Wang, Qingdong Han
RATIONALE: Tumor resection and extracranial-intracranial bypass concerning medial sphenoid ridge meningioma associated with severe stenosis of the internal carotid artery (ICA) of intracranial segments has been rarely presented. Effective treatment as to the complex lesions may be complicated. Tumor resection and cerebrovascular protection should be both taken into consideration. PATIENT CONCERNS: We presented one case of medial sphenoid ridge meningioma associated with severe stenosis of the internal carotid artery of intracranial segments...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29900089/staphylococcus-lugdunensis-endocarditis-and-cerebrovascular-accident-a-systemic-review-of-risk-factors-and-clinical-outcome
#17
REVIEW
Htoo Kyaw, Felix Raju, Atif Z Shaikh, Aung Naing Lin, Aye T Lin, Joseph Abboud, Sarath Reddy
Infective endocarditis (IE) secondary to Staphylococcus lugdunensis has been increasingly recognized since 1988. IE-related thromboembolism represents an associated complication of the disease and carries a dismal prognosis. However, the incidence of cerebrovascular accident secondary to S. lugdunensis IE is relatively uncommon and its treatment has not been clearly elucidated yet. We performed an extensive literature search using Pubmed, Medline, Scopus, and Google Scholar to identify the articles using the following keywords: 'Staphylococcus lugdunensis', 'infective endocarditis', 'stroke', and 'cerebrovascular accident...
April 12, 2018: Curēus
https://www.readbyqxmd.com/read/29899019/effect-of-change-in-total-cholesterol-levels-on-cardiovascular-disease-among-young-adults
#18
Su-Min Jeong, Seulggie Choi, Kyuwoong Kim, Sung Min Kim, Gyeongsil Lee, Seong Yong Park, Yeon-Yong Kim, Joung Sik Son, Jae-Moon Yun, Sang Min Park
BACKGROUND: Although high serum cholesterol in young adults is known to be a predictor for cardiovascular events, there is not enough evidence for the association of cholesterol level change with cardiovascular disease (CVD). This study aimed to evaluate whether the change in cholesterol is associated with incidence of CVD among young adults. METHODS AND RESULTS: We examined 2 682 045 young adults (aged 20-39 years) who had undergone 2 consecutive national health check-ups provided by Korean National Health Insurance Service between 2002 and 2005...
June 13, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29898968/association-between-diabetes-and-subsequent-parkinson-disease-a-record-linkage-cohort-study
#19
Eduardo De Pablo-Fernandez, Raph Goldacre, Julia Pakpoor, Alastair J Noyce, Thomas T Warner
OBJECTIVE: To investigate the association between type 2 diabetes mellitus (T2DM) and subsequent Parkinson disease (PD). METHODS: Linked English national Hospital Episode Statistics and mortality data (1999-2011) were used to conduct a retrospective cohort study. A cohort of individuals admitted for hospital care with a coded diagnosis of T2DM was constructed, and compared to a reference cohort. Subsequent PD risk was estimated using Cox regression models. Individuals with a coded diagnosis of cerebrovascular disease, vascular parkinsonism, drug-induced parkinsonism, and normal pressure hydrocephalus were excluded from the analysis...
June 13, 2018: Neurology
https://www.readbyqxmd.com/read/29898045/prevalence-and-factors-associated-with-metabolic-syndrome-among-brazilian-adult-population-national-health-survey-2013
#20
Elyssia Karine Nunes Mendonça Ramires, Risia Cristina Egito de Menezes, Giovana Longo-Silva, Taíse Gama Dos Santos, Patrícia de Menezes Marinho, Jonas Augusto Cardoso da Silveira
BACKGROUND: In Brazil, population-based researches analyzing prevalence and factors associated with metabolic syndrome (MS), a recognized predictor of cardiovascular diseases (CVD), and an important cause of disability and death in the country are scarce. OBJECTIVE: To evaluate prevalence of MS and its associated factors in Brazilian population. METHODS: Secondary analysis of the 2013 National Health Survey, a cross-sectional survey with national representativeness of Brazilian adult population (n = 59,402)...
May 2018: Arquivos Brasileiros de Cardiologia
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