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https://www.readbyqxmd.com/read/28748698/band-gap-engineering-of-titania-film-through-cobalt-regulation-for-oxidative-damage-of-bacteria-respiration-and-viability
#1
Jinhua Li, Jiaxing Wang, Donghui Wang, Geyong Guo, Kelvin Wai Kwok Yeung, Xianlong Zhang, Xuanyong Liu
Biomaterial-related bacterial infections cause patient suffering, mortality and extended periods of hospitalization, and impose a substantial burden on medical systems. In this context, understanding the interactions between nanomaterials and bacteria is clinically significant. Herein, TiO2-based heterojunctions including Co-TiO2, CoO-TiO2 and Co3O4-TiO2, were firstly designed by optimizing magnetron sputtering to establish a platform to explore the interactions between nanomaterials and bacteria. We found that the energy band bending and band gap narrowing were effectively promoted at the contact interface of the heterojunctions, which have the ability to induce abiotic reactive oxygen species formation...
July 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28748415/role-of-plasma-derived-fibrin-on-keratinocyte-and-fibroblast-wound-healing
#2
Jia Xian Law, Shiplu Roy Chowdhury, Bin Saim Aminuddin, Binti Haji Idrus Ruszymah
Fibrin has excellent biocompatibility and biological properties to support tissue regeneration and promote wound healing. However, the role of diluted fibrin in wound healing has yet to be elucidated as it is commonly used in high concentration. This study was aimed to examine the effects of diluted plasma-derived fibrin (PDF) on keratinocyte and fibroblast wound healing in term of cell proliferation, migration, extracellular matrix (ECM) production and soluble factor secretion. Two PDF concentrations, 10 and 20% (v/v) were tested on keratinocytes and fibroblasts indirectly co-cultured in the transwell system...
July 26, 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/28748212/genetically-engineered-multilineage-differentiating-stress-enduring-cells-as-cellular-vehicles-against-malignant-gliomas
#3
Tomohiro Yamasaki, Shohei Wakao, Hiroshi Kawaji, Shinichiro Koizumi, Tetsuro Sameshima, Mari Dezawa, Hiroki Namba
Malignant glioma, the most common malignant brain tumor in adults, is difficult to treat due to its aggressive invasive nature. Enzyme/prodrug suicide gene therapy based on the herpes simplex virus thymidine kinase (HSVtk)/ganciclovir (GCV) system is an efficient strategy for treating malignant gliomas. In the present study, we evaluated treatment with multilineage-differentiating stress-enduring (Muse) cells, which are endogenous non-tumorigenic pluripotent-like stem cells that are easily collectable from the bone marrow as SSEA-3(+) cells, as carriers of the HSVtk gene...
September 15, 2017: Molecular Therapy Oncolytics
https://www.readbyqxmd.com/read/28747970/reproductive-performance-of-genetically-engineered-mice-housed-in-different-housing-systems
#4
Shikha Yadav, Inderjeet Yadav, Kunal Pratap, Pradeep Kumar Tiwari, Vijay Pal Singh
The genetically engineered mice require special husbandry care and are mainly housed in Individually Ventilated Cage (IVC) systems and Static Micro Isolator Cages (SMIC) to minimize the risk for spreading undesirable microorganisms. However, the static micro isolation cage housing like SMIC are being replaced with IVC systems in many facilities due to a number of benefits like a higher density housing in limited space, better protection from biohazards and allergens and decreased work load due to decreased frequency of cage changing required in this system...
June 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/28747647/delivery-of-intracavernosal-therapies-using-needle-free-injection-devices
#5
D O'Kane, L Gibson, J du Plessis, A Davidson, D Bolton, N Lawrentschuk
ED affects a significant proportion of males worldwide. With an ever-aging population the prevalence of ED is predicted to double in the next decade. Oral PDE-5 inhibitors are the first-line treatment for ED and have revolutionised its management. These agents are however ineffective in some men. Intracavernosal injection (ICI) of vasoactive agents is an effective second-line therapy for ED. Despite proven efficacy, needle phobia and anxiety with self-needling limit the use of intracavernosal (IC) therapies...
July 27, 2017: International Journal of Impotence Research
https://www.readbyqxmd.com/read/28746304/complex-cellular-logic-computation-using-ribocomputing-devices
#6
Alexander A Green, Jongmin Kim, Duo Ma, Pamela A Silver, James J Collins, Peng Yin
Synthetic biology aims to develop engineering-driven approaches to the programming of cellular functions that could yield transformative technologies. Synthetic gene circuits that combine DNA, protein, and RNA components have demonstrated a range of functions such as bistability, oscillation, feedback, and logic capabilities. However, it remains challenging to scale up these circuits owing to the limited number of designable, orthogonal, high-performance parts, the empirical and often tedious composition rules, and the requirements for substantial resources for encoding and operation...
July 26, 2017: Nature
https://www.readbyqxmd.com/read/28745760/advances-in-spectroscopy-and-dynamics-of-small-and-medium-sized-molecules-and-clusters
#7
Majdi Hochlaf
Investigations of the spectroscopy and dynamics of small- and medium-sized molecules and clusters represent a hot topic in atmospheric chemistry, biology, physics, atto- and femto-chemistry and astrophysics. Nowadays, outstanding developments, both theoretical and experimental, have been achieved. The most recent results of these achievements are reviewed here. These molecular systems are studied by means of high-resolution spectroscopic techniques in either the frequency or the time domains. However, they still represent complex molecular systems since they may undergo processes that are still not fully understood in sufficient details...
July 26, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28745614/engineering-magnetism-at-functional-oxides-interfaces-manganites-and-beyond
#8
Di Yi, Nianpeng Lu, Xuegang Chen, Shengchun Shen, Pu Yu
The family of transition metal oxides (TMOs) is a large class of magnetic materials that has been intensively studied due to the rich physics involved as well as the promising potential applications in next generation electronic devices. In TMOs, the spin, charge, orbital and lattice are strongly coupled, and significant advances have been achieved to engineer the magnetism by different routes that manipulate these degrees of freedom. The family of manganites is a model system of strongly correlated magnetic TMOs...
July 26, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28745100/patient-and-provider-centered-design-of-an-outpatient-diabetes-technology-clinic
#9
Angela M Cramer, Patricia Scalzo, Sarah M Bach, Yogish C Kudva
The number of US patients using diabetes technology is increasing, and sophisticated technologies continue to emerge. Patients using diabetes technology require access to providers prepared to offer care in this rapidly changing field. The authors sought to identify factors important to both patients using diabetes technology and providers caring for such patients. They redesigned the Diabetes Technology Clinic at an academic group practice in response to the needs of patients and providers. Ongoing analysis of best practices, patient experience, and provider feedback is essential to structuring diabetes technology clinics to meet the complex needs of patients requiring diabetes technology...
May 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28744947/bmp-2-gene-activated-muscle-tissue-fragments-for-osteochondral-defect-regeneration-in-the-rabbit-knee
#10
Volker M Betz, Alexander Keller, Peter Foehr, Christian Thirion, Michael Salomon, Stefan Rammelt, Hans Zwipp, Rainer Burgkart, Volkmar Jansson, Peter E Müller, Oliver B Betz
BACKGROUND: Previously published data indicate that BMP-2 gene activated muscle tissue grafts can repair large bone defects in rats. This innovative abbreviated ex vivo gene therapy is appealing since it does not require elaborative and time-consuming extraction and expansion of cells. Hence, in the here presented experimental study we evaluated the potential of this expedited tissue engineering approach to regenerate osteochondral defects in rabbits. METHODS: Autologous muscle tissue grafts from female White New Zealand rabbits were directly transduced with an adenoviral BMP-2 vector or remained unmodified...
July 25, 2017: Journal of Gene Medicine
https://www.readbyqxmd.com/read/28744797/reconstructing-the-immune-system-with-lentiviral-vectors
#11
REVIEW
Henning Olbrich, Constanze Slabik, Renata Stripecke
Lentiviral vectors (LVs) developed in the past two decades for research and pre-clinical purposes have entered clinical trials with remarkable safety and efficacy performances. Development and clinical testing of LVs for improvement of human immunity showed major advantages in comparison to other viral vector systems. Robust and persisted transduction efficiency of blood cells with LVs, resulted into a broad range of target cells for immune therapeutic approaches: from hematopoietic stem cells and precursor cells for correction of immune deficiencies, up to effector lymphoid and myeloid cells...
July 25, 2017: Virus Genes
https://www.readbyqxmd.com/read/28743858/triggerable-tough-hydrogels-for-gastric-resident-dosage-forms
#12
Jinyao Liu, Yan Pang, Shiyi Zhang, Cody Cleveland, Xiaolei Yin, Lucas Booth, Jiaqi Lin, Young-Ah Lucy Lee, Hormoz Mazdiyasni, Sarah Saxton, Ameya R Kirtane, Thomas von Erlach, Jaimie Rogner, Robert Langer, Giovanni Traverso
Systems capable of residing for prolonged periods of time in the gastric cavity have transformed our ability to diagnose and treat patients. Gastric resident systems for drug delivery, ideally need to be: ingestible, be able to change shape or swell to ensure prolonged gastric residence, have the mechanical integrity to withstand the forces associated with gastrointestinal motility, be triggerable to address any side effects, and be drug loadable and release drug over a prolonged period of time. Materials that have been primarily utilized for these applications have been largely restricted to thermoplastics and thermosets...
July 25, 2017: Nature Communications
https://www.readbyqxmd.com/read/28743819/positive-autoregulation-of-an-acyl-homoserine-lactone-quorum-sensing-circuit-synchronizes-the-population-response
#13
Rebecca L Scholz, E Peter Greenberg
Many proteobacteria utilize acyl-homoserine lactone quorum-sensing signals. At low population densities, cells produce a basal level of signal, and when sufficient signal has accumulated in the surrounding environment, it binds to its receptor, and quorum-sensing-dependent genes can be activated. A common characteristic of acyl-homoserine lactone quorum sensing is that signal production is positively autoregulated. We have examined the role of positive signal autoregulation in Pseudomonas aeruginosa We compared population responses and individual cell responses in populations of wild-type P...
July 25, 2017: MBio
https://www.readbyqxmd.com/read/28743817/bacterial-signaling-nucleotides-inhibit-yeast-cell-growth-by-impacting-mitochondrial-and-other-specifically-eukaryotic-functions
#14
Andy Hesketh, Marta Vergnano, Chris Wan, Stephen G Oliver
We have engineered Saccharomyces cerevisiae to inducibly synthesize the prokaryotic signaling nucleotides cyclic di-GMP (cdiGMP), cdiAMP, and ppGpp in order to characterize the range of effects these nucleotides exert on eukaryotic cell function during bacterial pathogenesis. Synthetic genetic array (SGA) and transcriptome analyses indicated that, while these compounds elicit some common reactions in yeast, there are also complex and distinctive responses to each of the three nucleotides. All three are capable of inhibiting eukaryotic cell growth, with the guanine nucleotides exhibiting stronger effects than cdiAMP...
July 25, 2017: MBio
https://www.readbyqxmd.com/read/28743780/supply-chain-optimization-at-an-academic-medical-center
#15
Jonathan Labuhn, Philip Almeter, Christopher McLaughlin, Philip Fields, Benjamin Turner
PURPOSE: A successful supply chain optimization project that leveraged technology, engineering principles, and a technician workflow redesign in the setting of a growing health system is described. SUMMARY: With continued rises in medication costs, medication inventory management is increasingly important. Proper management of central pharmacy inventory and floor-stock inventory in automated dispensing cabinets (ADCs) can be challenging. In an effort to improve control of inventory costs in the central pharmacy of a large academic medical center, the pharmacy department implemented a supply chain optimization project in collaboration with the medical center's inhouse team of experts on process improvement and industrial engineering...
August 1, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28743485/content-of-web-based-continuing-medical-education-about-hpv-vaccination
#16
Melanie L Kornides, Jacob M Garrell, Melissa B Gilkey
BACKGROUND: Addressing low HPV vaccination coverage will require U.S. health care providers to improve their recommendation practices and vaccine delivery systems. Because readily available continuing medical education (CME) could be an important tool for supporting providers in this process, we sought to assess the content of web-based CME activities related to HPV vaccination. METHODS: We conducted a content analysis of web-based CME activities about HPV vaccination available to U...
July 22, 2017: Vaccine
https://www.readbyqxmd.com/read/28743272/establishment-of-neurospora-crassa-as-a-host-for-heterologous-protein-production-using-a-human-antibody-fragment-as-a-model-product
#17
David Havlik, Ulrike Brandt, Kathrin Bohle, André Fleißner
BACKGROUND: Filamentous fungi are commonly used as production hosts for bulk enzymes in biotechnological applications. Their robust and quick growth combined with their ability to secrete large amounts of protein directly into the culture medium makes fungi appealing organisms for the generation of novel production systems. The red bread mold Neurospora crassa has long been established as a model system in basic research. It can be very easily genetically manipulated and a wealth of molecular tools and mutants are available...
July 25, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/28743188/nanocomposite-hydrogels-for-cartilage-tissue-engineering-a-review
#18
Nahideh Asadi, Effat Alizadeh, Roya Salehi, Bahar Khalandi, Soodabeh Davaran, Abolfazl Akbarzadeh
The loss of cartilaginous tissues is an important challenge to orthopaedic surgeons. Injury to cartilage tissue due to its properties is along with movement difficulties. Tissue engineering is a developing field that can be used for regeneration or replacement of damaged tissues. In this field, an appropriate scaffold that support the recruitment, adhesion, proliferation and differentiation of cells is necessary. Hydrogels recently considered as materials that resemble the extracellular matrix (ECM) and efficiently replace defective tissues, but they have limited mechanical strength...
July 25, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28743068/applying-monte-carlo-simulations-to-optimize-an-inelastic-neutron-scattering-system-for-soil-carbon-analysis
#19
Galina Yakubova, Aleksandr Kavetskiy, Stephen A Prior, H Allen Torbert
Computer Monte-Carlo (MC) simulations (Geant4) of neutron propagation and acquisition of gamma response from soil samples was applied to evaluate INS system performance characteristic [minimal detectible level (MDL), sensitivity] for soil carbon measurement. The INS system model with best performance characteristics was determined based on MC simulation results. Measurements of MDL using an experimental prototype based on this model demonstrated good agreement with simulated data. This prototype will be used as the base engineering design for a new INS system...
July 5, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28743041/prospects-for-engineering-and-improvement-of-cross-protective-virus-strains
#20
REVIEW
Heiko Ziebell, Robin MacDiarmid
Mild strain cross-protection is currently an important method for the production of high quality plant products; despite challenge from severe virus isolates the initial protecting strain precludes symptom development. The mechanism of cross-protection is not yet resolved as RNA silencing does not sufficiently explain the phenomenon. Six requirements have been put forward to ensure long-lasting protection. We propose two additional requirements for effective and durable mild strain cross-protection; mild strains based on knowledge of the mechanism and consideration of impacts to consumers...
July 22, 2017: Current Opinion in Virology
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