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https://www.readbyqxmd.com/read/28214828/role-for-target-of-rapamycin-mtor-signal-pathway-in-regulating-neuronal-injury-after-intracerebral-hemorrhage
#1
Jie-Ping Wang, Meng-Yu Zhang
BACKGROUND/AIMS: Mammalian target of rapamycin (mTOR) is a serine/threonine protein kinase and activation of its signal pathway plays an important role in regulating protein growth and synthesis as well as cell proliferation and survival. In the present study, we examined the contribution of mTOR signal and its downstream products to brain injuries induced by intracerebral hemorrhage (ICH) in rats. METHODS: Western Blot analysis was employed to examine the protein expression of mTOR and its downstream pathway and Caspase-3...
January 18, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28206667/geometry-calibration-method-for-a-cone-beam-ct-system
#2
Hongkai Yang, Kejun Kang, Yuxiang Xing
PURPOSE: The positioning accuracy of each component is important to ensure the image quality of cone-beam CT. However, accurate positioning is not easy and requires experience and time. The option is to calibrate the geometric parameters and then plug them into a reconstruction algorithm which is the preferred solution in practice. In this case, the image quality is determined by the accuracy and precision of the calibration method. This work describes a method to independently calibrate an imaging system in each pose (projection angle) for a cone-beam CT with a non-ideal-circular trajectory...
February 16, 2017: Medical Physics
https://www.readbyqxmd.com/read/28197757/versatile-methodology-to-encapsulate-gold-nanoparticles-in-plga-nanoparticles-obtained-by-nano-emulsion-templating
#3
Cristina Fornaguera, Natàlia Feiner-Gracia, Aurora Dols-Perez, Maria José García-Celma, Conxita Solans
PURPOSE: Gold nanoparticles have been proved useful for many biomedical applications, specifically, for their use as advanced imaging systems. However, they usually present problems related with stability and toxicity. METHODS: In the present work, gold-nanoparticles have been encapsulated in polymeric nanoparticles using a novel methodology based on nano-emulsion templating. Firstly, gold nanoparticles have been transferred from water to ethyl acetate, a solvent classified as class III by the NIH guidelines (low toxic potential)...
February 14, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28188064/the-impact-of-the-patient-post-intensive-care-syndrome-components-upon-caregiver-burden
#4
J Torres, D Carvalho, E Molinos, C Vales, A Ferreira, C C Dias, R Araújo, E Gomes
OBJECTIVE: To evaluate patient post-intensive care syndrome (PICS-P) and caregiver burden 3 months after discharge from the Intensive Care Unit (ICU) and determine the impact of different components of PICS-P upon caregiver burden. DESIGN: A prospective observational study was conducted over 26 months (January 2013-February 2015). SETTING: Medical-surgical ICU and follow-up consultation in Portugal. PATIENTS OR PARTICIPANTS: Patients discharged after a minimum of 2 days in the ICU...
February 7, 2017: Medicina Intensiva
https://www.readbyqxmd.com/read/28187769/gastric-perforation-following-cytoreductive-surgery-and-perioperative-intraperitoneal-chemotherapy-a-case-series-of-six
#5
Lee S Kyang, Nayef A Alzahrani, Jing Zhao, David L Morris
BACKGROUND: Incidence of gastric perforation following cytoreductive surgery (CRS) and perioperative intraperitoneal chemotherapy (PIC) is not widely reported. METHODS: Suitable patients were identified from our database of 1028 procedures. Relevant information was then gathered via medical records and operation reports for these patients. RESULTS: Six patients suffered early postoperative gastric perforation following the procedure (0.58%), all of whom received heated intraoperative intraperitoneal chemotherapy (HIPEC)...
February 10, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28187178/genome-wide-assessment-of-population-structure-and-genetic-diversity-and-development-of-a-core-germplasm-set-for-sweet-potato-based-on-specific-length-amplified-fragment-slaf-sequencing
#6
Wenjin Su, Lianjun Wang, Jian Lei, Shasha Chai, Yi Liu, Yuanyuan Yang, Xinsun Yang, Chunhai Jiao
Sweet potato, Ipomoea batatas (L.) Lam., is an important food crop that is cultivated worldwide. However, no genome-wide assessment of the genetic diversity of sweet potato has been reported to date. In the present study, the population structure and genetic diversity of 197 sweet potato accessions most of which were from China were assessed using 62,363 SNPs. A model-based structure analysis divided the accessions into three groups: group 1, group 2 and group 3. The genetic relationships among the accessions were evaluated using a phylogenetic tree, which clustered all the accessions into three major groups...
2017: PloS One
https://www.readbyqxmd.com/read/28187131/genome-size-cytogenetic-data-and-transferability-of-est-ssrs-markers-in-wild-and-cultivated-species-of-the-genus-theobroma-l-byttnerioideae-malvaceae
#7
Rangeline Azevedo da Silva, Gustavo Souza, Lívia Santos Lima Lemos, Uilson Vanderlei Lopes, Nara Geórgia Ribeiro Braz Patrocínio, Rafael Moysés Alves, Lucília Helena Marcellino, Didier Clement, Fabienne Micheli, Karina Peres Gramacho
The genus Theobroma comprises several trees species native to the Amazon. Theobroma cacao L. plays a key economic role mainly in the chocolate industry. Both cultivated and wild forms are described within the genus. Variations in genome size and chromosome number have been used for prediction purposes including the frequency of interspecific hybridization or inference about evolutionary relationships. In this study, the nuclear DNA content, karyotype and genetic diversity using functional microsatellites (EST-SSR) of seven Theobroma species were characterized...
2017: PloS One
https://www.readbyqxmd.com/read/28185984/hydrogen-sulfide-in-paraventricular-nucleus-attenuates-blood-pressure-by-regulating-oxidative-stress-and-inflammatory-cytokines-in-high-salt-induced-hypertension
#8
Yan-Feng Liang, Dong-Dong Zhang, Xiao-Jing Yu, Hong-Li Gao, Kai-Li Liu, Jie Qi, Hong-Bao Li, Qiu-Yue Yi, Wen-Sheng Chen, Wei Cui, Guo-Qing Zhu, Yu-Ming Kang
Hydrogen sulfide (H2S) is an important gaseous signaling molecule in neuro-modulation, anti-inflammatory, anti-oxidant and anti-hypertensive effects. The paraventricular nucleus (PVN) is a major integrative nucleus in regulating BP and SNA. The aim of this study is to explore whether endogenous or exogenous H2S changed by hydroxylamine hydrochloride (HA) or GYY4137 infused in the PVN affects RSNA and MAP by regulating oxidative stress or the balance between pro-inflammatory cytokines (PICs) and anti-inflammatory cytokines in high salt-induced hypertensive rats...
February 6, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28183117/-i-neolinoptes-i-gen-n-a-replacement-name-for-the-net-winged-beetle-genus-i-linoptes-i-gorham-1884-and-a-new-species-of-i-lycomorphon-i-from-guyana-coleoptera-lycidae
#9
Elynton Alves DO Nascimento, Milada Bocakova
Neolinoptes gen. n. is erected to replace Linoptes Gorham, 1884, preoccupied by Linoptes Menge, 1854 (Arachnida: Araneae). Consequently, Neolinoptes imbrex (Gorham, 1884) comb. n., N. amazonicus (Pic, 1923) comb. n., N. atronotatus (Pic, 1922) comb. n., N. atripennis (Pic, 1932) comb. n. are proposed. Calocladon rubidum Gorham, 1884 is transferred to Neolinoptes. Lycomorphon iwokrama sp. n. is proposed as new to science and the genus is recorded from Guyana for the first time. Additionally, Falsocaenia irregularis var...
January 9, 2017: Zootaxa
https://www.readbyqxmd.com/read/28181619/phosphatase-triggered-cell-selective-release-of-a-pt-iv-backboned-prodrug-like-polymer-for-an-improved-therapeutic-index
#10
Shao-Lu Li, Yingqin Hou, Yali Hu, Jin Yu, Wei Wei, Hua Lu
We describe here the synthesis and cell-selective delivery of a cationic Pt(iv)-backboned prodrug-like polymer P(DSP-DAEP). P(DSP-DAEP) features excellent aqueous solubility, unusually high (44.5%) drug loading, can be rapidly reduced to release the active cisplatin, and is more potent than its small molecular Pt(iv) precursor DSP. P(DSP-DAEP) can be formulated with an oppositely charged methoxyl poly(ethylene glycol)-block-poly(l-phosphotyrosine) (mPEG-b-PpY) to afford a polyion micelle (Pt-PIC) by taking advantage of polyelectrolyte coacervation...
February 9, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28177384/effects-of-distillers-dried-grains-with-solubles-and-added-fat-fed-immediately-before-slaughter-on-growth-performance-and-carcass-characteristics-of-finishing-pigs
#11
K F Coble, J M DeRouchey, M D Tokach, S S Dritz, R D Goodband, J C Woodworth
The addition of dietary fat has been shown to increase HCW and carcass yield in pigs fed low-fiber corn-soy diets; however, data on added fat in high-fiber, low-energy diets is less available. Therefore, the potential for dietary fat to ameliorate the negative effect high-fiber diets have on carcass yield during the last 3 wk before slaughter is of high importance. This experiment was conducted to determine the interactive effects of 30% distillers dried grains with solubles (DDGS) and 5% added fat fed before slaughter on growth performance and carcass characteristics...
January 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28169832/interface-between-40s-exit-channel-protein-us7-rps5-and-eif2%C3%AE-modulates-start-codon-recognition-in-vivo
#12
Jyothsna Visweswaraiah, Alan G Hinnebusch
The eukaryotic pre-initiation complex (PIC) bearing the eIF2•GTP•Met-tRNAi(Met) ternary complex (TC) scans the mRNA for an AUG codon in favorable context. AUG recognition evokes rearrangement of the PIC from an open, scanning to a closed, arrested conformation. Cryo-EM reconstructions of yeast PICs suggest remodeling of the interface between 40S protein Rps5/uS7 and eIF2α between open and closed states; however, its importance was unknown. uS7 substitutions disrupting eIF2α contacts favored in the open complex increase initiation at suboptimal sites, and uS7-S223D stabilizes TC binding to PICs reconstituted with a UUG start codon, indicating inappropriate rearrangement to the closed state...
February 7, 2017: ELife
https://www.readbyqxmd.com/read/28166447/nutrition-support-for-persistent-inflammation-immunosuppression-and-catabolism-syndrome
#13
Frederick A Moore, Stuart Phillips, Craig McClain, Jayshil J Patel, Robert Martindale
Despite tremendous advances in critical care, multiple-organ failure continues to be a significant problem. However, in recent years, far fewer patients with multiple-organ failure die early, but many experience ongoing immune dysregulation and are developing persistent inflammation, immunosuppression, and catabolism syndrome (PICS). Most PICS patients are discharged to nonhome destinations, fail to rehabilitate, and succumb to indolent death. From a nutrition perspective, patients with PICS experience persistent inflammation-induced cachexia despite evidenced-based recommended intensive care unit nutrition support...
February 1, 2017: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/28163598/ssr-marker-assisted-screening-of-commercial-tomato-genotypes-under-salt-stress
#14
Charfeddine Gharsallah, Ahmed Ben Abdelkrim, Hatem Fakhfakh, Amel Salhi-Hannachi, Faten Gorsane
Salt stress was applied to tomato commercial genotypes to study adverse effects on their phenotypic traits. Three were saline tolerant (San Miguel, Romelia and Llanero), two were mildly tolerant (Perfect peel HF1 and Heinz 1350) whereas the remaining were sensitive. Genotyping cultivars using 19 polymorphic SSRs out of 25 tested produced a total of 70 alleles with an average of 3.68 alleles per locus and PIC values ranging from 0.22 (SSR 26, 92, 66 and TG35) to 0.82 (SSR 356). Principal component analysis (PCA) showed two contrasting panels discriminating tolerant and sensitive groups and one panel with scattered genotypes...
December 2016: Breeding Science
https://www.readbyqxmd.com/read/28154429/grafting-and-paladin-pic-21-for-nematode-and-weed-management-in-vegetable-production
#15
Nancy Kokalis-Burelle, David M Butler, Jason C Hong, Michael G Bausher, Greg McCollum, Erin N Rosskopf
Two years of field trials conducted in a Meloidogyne incognita-infested field evaluated grafting and Paladin Pic-21 (dimethyl disulfide:chloropicrin [DMDS:Pic] 79:21) for root-knot nematode and weed control in tomato and melon. Tomato rootstocks evaluated were; 'TX301', 'Multifort', and 'Aloha'. 'Florida 47' was the scion and the nongrafted control. A double crop of melon was planted into existing beds following tomato harvest. Melon rootstocks, C. metulifer and 'Tetsukabuto', were evaluated with nongrafted 'Athena' in year 1...
December 2016: Journal of Nematology
https://www.readbyqxmd.com/read/28138030/the-tlr3-agonist-inhibit-drug-efflux-and-sequentially-consolidates-low-dose-cisplatin-based-chemoimmunotherapy-while-reducing-side-effects
#16
Liang Ding, Jing Ren, Dongya Zhang, Yi Li, XiaoFeng Huang, Jianjian Ji, Qingang Hu, Hui Wang, Yanhong Ni, Yayi Hou
The traditional maximum dose density chemotherapy renders the tumor patients not only the tumor remission but the chemotherapy resistance and more adverse side effects. According to the widely positive expression of Toll-like receptor (TLR)-3 in oral squamous cell carcinoma (OSCC) patients (n=166), we here provided an alternative strategy involved the orderly treatment of TLR3 agonist polyinosine-polycytidylic acid (PIC) and low-dose cisplatin. The optimal dose of cisplatin, the novel role of PIC and the side effects of the combined chemotherapy were determined in vitro and in distinct human tumor models in vivo...
January 30, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28135299/single-marker-and-haplotype-based-association-analysis-of-semolina-and-pasta-colour-in-elite-durum-wheat-breeding-lines-using-a-high-density-consensus-map
#17
Amidou N'Diaye, Jemanesh K Haile, Aron T Cory, Fran R Clarke, John M Clarke, Ron E Knox, Curtis J Pozniak
Association mapping is usually performed by testing the correlation between a single marker and phenotypes. However, because patterns of variation within genomes are inherited as blocks, clustering markers into haplotypes for genome-wide scans could be a worthwhile approach to improve statistical power to detect associations. The availability of high-density molecular data allows the possibility to assess the potential of both approaches to identify marker-trait associations in durum wheat. In the present study, we used single marker- and haplotype-based approaches to identify loci associated with semolina and pasta colour in durum wheat, the main objective being to evaluate the potential benefits of haplotype-based analysis for identifying quantitative trait loci...
2017: PloS One
https://www.readbyqxmd.com/read/28135294/evaluation-of-the-protective-efficacy-of-poly-i-c-as-an-adjuvant-for-h9n2-subtype-avian-influenza-inactivated-vaccine-and-its-mechanism-of-action-in-ducks
#18
Aiguo Zhang, Hanzhang Lai, Jiahua Xu, Wenke Huang, Yufu Liu, Dawei Zhao, Ruiai Chen
Current commercial H9 avian influenza vaccines cannot provide satisfactory protective immunity against antigenic variant influenza viruses in ducks. Poly I:C, when used as an adjuvant, improves humoral and cellular immunity in many animals but has not been tested in ducks. In this study, we investigated the protective efficacy of Poly I:C as an adjuvant for an inactivated H9N2 Avian influenza vaccine in ducks. We found that an H9N2 vaccine administered with poly I:C (H9-PIC vaccine) induced a significantly more rapid response with higher anti-influenza antibody titers than those of the vaccine alone (H9 vaccine)...
2017: PloS One
https://www.readbyqxmd.com/read/28135100/zinc-oxide-nanoparticle-poly-i-c-rna-complexes-implication-as-therapeutics-against-experimental-melanoma
#19
Meghana Ramani, Miranda C Mudge, R Tyler Morris, Yuntao Zhang, Stanislaw A Warcholek, Miranda N Hurst, Jim E Riviere, Robert K DeLong
There is current interest in harnessing the combined anti-cancer and immunological effect of nanoparticles (NP) and RNA. Here, we evaluate the bio-activity of poly I:C (pIC) RNA, bound to anti-cancer zinc oxide NP (ZnO-NP) against melanoma. Direct RNA association to unfunctionalized ZnO-NP is shown by observing change in size, zeta potential and absorption/fluorescence spectra upon complexation. RNA corona was visualized by transmission electron microscopy (TEM) for the first time. Binding constant (Kb = 1...
January 30, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28133791/the-effect-of-different-protease-inhibitors-on-stability-of-parathyroid-hormone-insulin-and-prolactin-levels-under-different-lag-times-and-storage-conditions-until-analysis
#20
Ozgur Baykan, Ali Yaman, Fethullah Gerin, Onder Sirikci, Goncagul Haklar
INTRODUCTION: Proteolytic cleavage through proteases affects peptide hormone levels, which is of particular significance when the time interval between sampling and analysis is prolonged. We evaluated the stability of parathyroid hormone, insulin, and prolactin molecules (i) with different protease inhibitors such as K2 EDTA, aprotinin, and protease inhibitor cocktail (PIC), (ii) with different lag times (6-72 hours), and (iii) under different storage temperatures (4°C vs room temperature [RT]) until analysis...
January 30, 2017: Journal of Clinical Laboratory Analysis
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