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Aleksandra Klimczak, Urszula Kozlowska, Maciej Kurpisz
Muscular dystrophies represent a group of diseases which may develop in several forms, and severity of the disease is usually associated with gene mutations. In skeletal muscle regeneration and in muscular dystrophies, both innate and adaptive immune responses are involved. The regenerative potential of mesenchymal stem/stromal cells (MSCs) of bone marrow origin was confirmed by the ability to differentiate into diverse tissues and by their immunomodulatory and anti-inflammatory properties by secretion of a variety of growth factors and anti-inflammatory cytokines...
March 13, 2018: Archivum Immunologiae et Therapiae Experimentalis
Eny Kusrini, Fatimah Hashim, Cindy Gunawan, Riti Mann, Wan Nor Nadhirah Wan Noor Azmi, Nakisah Mat Amin
This work investigated the anti-amoebic activity of two samarium (Sm) complexes, the acyclic complex [bis(picrato)(pentaethylene glycol)samarium(III)] picrate-referred to as [Sm(Pic)2 (EO5)](Pic)-and the cyclic complex [bis(picrato)(18-crown-6)samarium(III)] picrate-referred to as [Sm(Pic)2 (18C6)](Pic). Both Sm complexes caused morphological transformation of the protozoa Acanthamoeba from its native trophozoite form carrying a spine-like structure called acanthopodia, to round-shaped cells with loss of the acanthopodia structure, a trademark response to environmental stress...
March 12, 2018: Parasitology Research
Sandra P Amaral, Maun H Tawara, Marcos Fernandez-Villamarin, Erea Borrajo, José Martínez-Costas, Anxo Vidal, Ricardo Riguera, Eduardo Fernandez-Megia
Herein we describe that the generation of dendrimers represents a powerful tool in the control of the size and biodistribution of polyion complexes (PIC). Using a combinatorial screening of six dendrimers (18-243 terminal groups) and five oppositely charged PEGylated copolymers, a dendrimer to PIC hierarchical transfer of structural information was revealed with PIC diameters that increased from 80 to 500 nm on decreasing the dendrimer generation. This rise in size, also accompanied by a micelle to vesicle transition, is interpreted according to a cone- to rod-shaped progression in the architecture of the unit PIC (uPIC)...
March 12, 2018: Angewandte Chemie
Luciana Gueiros da Motta, Juliana Alves de Morais, Ana Carolina A M Tavares, Leonora Maciel Sousa Vianna, Marcia Renata Mortari, Rivadávio Fernandes Batista Amorim, Rosângela R Carvalho, Francisco José R Paumgartten, Aline Pic-Taylor, Eloisa Dutra Caldas
Rats were treated orally with ayahuasca (AYA) on gestation days (GD) 6-20 at doses corresponding to one-(1X) to eight-fold (8X) the average dose taken by a human adult in a religious ritual, and the pregnancy outcome evaluated on GD21. Rats treated with 4X and 8X doses died during the treatment period (44 and 52%), and those that survived showed kidney injury. Rats surviving the 8X dose showed neuronal loss in hippocampal regions and in the raphe nuclei, and those from the 2X dose neuronal loss in CA1. Delayed intrauterine growth, induced embryo deaths and increased occurrence of foetal anomalies were observed at the 8X dose...
March 6, 2018: Reproductive Toxicology
Enshe Jiang, Andrew D Chapp, Yuanyuan Fan, Robert A Larson, Taija Hahka, Michael J Huber, Jianqun Yan, Qing-Hui Chen, Zhiying Shan
Accumulating evidence indicates that inflammation is implicated in hypertension. However, the role of brain proinflammatory cytokines (PICs) in salt sensitive hypertension remains to be determined. Thus, the objective of this study was to test the hypothesis that high salt (HS) diet increases PICs expression in the paraventricular nucleus (PVN) and leads to PVN neuronal activation. Eight-week-old male Dahl salt sensitive (Dahl S) rats, and age and sex matched normal Sprague Dawley (SD) rats were divided into two groups and fed with either a HS (4% NaCl) or normal salt (NS, 0...
2018: Frontiers in Physiology
Kinan G Zeno, Joseph G Ghafari
INTRODUCTION: The severity of a palatally impacted canine (PIC) is gauged radiographically on 2-dimensional and 3-dimensional positional components: eg, angulation and height. We hypothesized that the position of a PIC relative to its virtual alignment in the arch is a better indication of impaction severity and treatment requirements. The aims of this research were to evaluate variations in PIC location on 3-dimensional images and to determine positional components associated with impaction severity...
March 2018: American Journal of Orthodontics and Dentofacial Orthopedics
Yun-Li Zhao, Zi-Feng Yang, Jian-Hua Shang, Wan-Yi Huang, Bei Wang, Xin Wei, Afsar Khan, Zhi-Wei Yuan, Ya-Ping Liu, Yi-Fen Wang, Xin-Hua Wang, Xiao-Dong Luo
ETHNOPHARMACOLOGICAL RELEVANCE: Leaf of Alstonia scholaris (L.) R. Br. (Apocynaceae), a wide used ethic-medicine in many Asia and Africa counties, has also been recorded as the common traditional Chinese medicine for treatment of illnesses in respiratory system by Dai people. AIM OF THE STUDY: To provide experimental data of clinical adaption of total indole alkaloids (TA) from leaf of A. scholaris for treating post-infectious cough in phase II clinical trial. MATERIALS AND METHODS: To model post-infectious cough, all animals except control group were instilled intra-tracheal with lipopolysaccharide (LPS) (80μg/50μL/mouse), followed by subsequent exposure to cigarette smoke (CS) for 30min per day for a total of 30 days...
February 26, 2018: Journal of Ethnopharmacology
Christiane S Hartog, Konrad Reinhart
PURPOSE OF REVIEW: End-of-life (EOL) care can be stressful for clinicians as well as patients and their relatives. Decisions to withhold or withdraw life-sustaining therapy vary widely depending on culture, beliefs and organizational norms. The following review will describe the current understanding of the problem and give an overview over interventional studies. RECENT FINDINGS: EOL care is a risk factor for clinician burnout; poor work conditions contribute to emotional exhaustion and intent to leave...
April 2018: Current Opinion in Anaesthesiology
M Akbari, H Salehi, A Niazi
The main goals of the present study were to screen Iranian common bermudagrasses to find cold-tolerant accessions and evaluate their genetic and morphological variabilities. In this study, 49 accessions were collected from 18 provinces of Iran. One foreign cultivar of common bermudagrass was used as control. Morphological variation was evaluated based on 14 morphological traits to give information about taxonomic position of Iranian common bermudagrass. Data from morphological traits were evaluated to categorize all accessions as either cold sensitive or tolerant using hierarchical clustering with Ward's method in SPSS software...
February 26, 2018: Molecular Biotechnology
S Parthiban, P Govindaraj, S Senthilkumar
Twenty-five primer pairs developed from genomic simple sequence repeats (SSR) were compared with 25 expressed sequence tags (EST) SSRs to evaluate the efficiency of these two sets of primers using 59 sugarcane genetic stocks. The mean polymorphism information content (PIC) of genomic SSR was higher (0.72) compared to the PIC value recorded by EST-SSR marker (0.62). The relatively low level of polymorphism in EST-SSR markers may be due to the location of these markers in more conserved and expressed sequences compared to genomic sequences which are spread throughout the genome...
March 2018: 3 Biotech
Joanne L Gusella, Anna G Campbell, Kristin Lalji
Family-based treatment (FBT) has emerged as a promising approach for medically stable youth with anorexia nervosa (AN). While there is evidence that therapists embrace the core principles of FBT, most face barriers in implementing the model with fidelity. Little research has been conducted to determine whether adhering to the core methods of placing parents in charge are sufficient in restoring weight in youth with AN. This study involved a chart review of youth under 16 years of age, treated by a Canadian tertiary care health centre-based eating disorders team (EDT)...
August 2017: Paediatrics & Child Health
Lulan Zeng, Ningbo Chen, Yibo Yao, Ruihua Dang, Hong Chen, Chuzhao Lei
To determine the genetic diversity and validate the pedigree record of Chinese Guanzhong horse, 67 individuals were genotyped with eight microsatellite markers. In our study, the mean observed and expected heterozygosities were 0.51 and 0.66, respectively. The mean observed number of alleles for the Guanzhong horse was 3.88. Nonetheless, the total value of FST multiloci clearly indicates that about 0.5% of overall genetic variation is due to line founder differences, while differences among individuals are responsible for the remaining 99...
February 20, 2018: Animal Biotechnology
Joanna L Stollings, Sarah L Bloom, Li Wang, E Wesley Ely, James C Jackson, Carla M Sevin
BACKGROUND: Many patients experience complications following critical illness; these are now widely referred to as post-intensive care syndrome (PICS). An interprofessional intensive care unit (ICU) recovery center (ICU-RC), also known as a PICS clinic, is one potential approach to promoting patient and family recovery following critical illness. OBJECTIVES: To describe the role of an ICU-RC critical care pharmacist in identifying and treating medication-related problems among ICU survivors...
February 1, 2018: Annals of Pharmacotherapy
Edward M Sion, Patrick Godon, Liam Jones
The old novae V533 Her (Nova Her 1963), DI Lac (Nova Lac 1910), and RR Pic (Nova Pic 1891) are in (or near) their quiescent stage, following their nova explosions, and continue to accrete at a high rate in the aftermath of their explosions. They exhibit continua that are steeply rising into the FUV, as well as absorption lines and emission lines of uncertain origin. All three have Far Ultraviolet Spectroscopic Explorer ( FUSE ) spectra that offer not only higher spectral resolution but also wavelength coverage extending down to the Lyman Limit...
March 2017: Astronomical Journal
Wenyan Xu, Yao Xiao, Pengfeng Luo, Lihong Fan
C‑phycocyanin peptide (CPC) grafted N‑succinyl chitosan (NSC) was prepared via the catalysis of Microbial transglutaminase (MTGase). The single factor experiment displayed that the degree of substitution (DS) of N‑succinyl chitosan‑C‑phycocyanin peptide (NSC‑CPC) depended on the reaction time, the reaction temperature and the reaction pH value. The CS, synthesized NSC and NSC‑CPC were characterized by Fourier transform infrared spectroscopy (FT-IR). NSC‑CPC showed excellent moisture absorption and retention ability...
February 15, 2018: International Journal of Biological Macromolecules
Jakub Zimoch, Joan Simó Padial, Agnes S Klar, Queralt Vallmajo-Martin, Martin Meuli, Thomas Biedermann, Christopher J Wilson, Alan Rowan, Ernst Reichmann
Molecular and mechanical interactions with the 3D extracellular matrix are essential for cell functions such as survival, proliferation, migration, and differentiation. Thermo-responsive biomimetic polyisocyanopeptide (PIC) hydrogels are promising new candidates for 3D cell, tissue, and organ cultures. This is a synthetic, thermo-responsive and stress-stiffening material synthesized via polymerization of the corresponding monomers using a nickel perchlorate as a catalyst. It can be tailored to meet various demands of cells by modulating its stiffness and through the decoration of the polymer with short GRGDS peptides using copper free click chemistry...
February 14, 2018: Acta Biomaterialia
Koichi Takao, Hideaki Yahagi, Yoshihiro Uesawa, Yoshiaki Sugita
A series of novel 3-(E)-styryl-2H-chromene derivatives were synthesized and their monoamine oxidase (MAO) A and B inhibitory activities were evaluated. All compounds exhibited no inhibitory activity towards MAO-A at 10 μM whereas compounds 1-5, 7, 9, 11-13, 15 and 16 showed strong inhibitory activity towards MAO-B at this concentration. Of these, compound 3, which contains fluorine at R 3 , showed the highest activity (IC 50 = 10 nM), and is about 22-fold more potent than pargyline (used as a positive control)...
February 7, 2018: Bioorganic Chemistry
Siti Nor Ain Seri Masran, Abdul Hafiz Ab Majid
Due to the growing public health and tourism awareness, Cimex hemipterus Fabricius (Hemiptera: Cimicidae) has gained a great interest in increasing reported infestation cases in tropical regions of the world, including Malaysia. Since the information on the molecular ecology and population biology of this species are tremendously lacking, the isolation and development of molecular markers can be used to determine its genetic structure. In this study, novel microsatellite primers isolated from enriched genomic libraries of C...
February 10, 2018: Journal of Medical Entomology
Shoichi Katsuta, Yuki Saito, Suguru Takahashi
The solvent-extraction behavior of Li+ and Na+ with a Li+ selective metallacrown, [{Ru(η6-3,5-dimethylanisole)(2,3-pyridinediolate)}3], was investigated in the presence of organic dye anions, 3',3″,5',5″-tetrabromophenolphthalein ethyl ester ([TBPE]-), 2,6-dichloroindophenolate, and picrate ([pic]-). Each alkali metal ion was extracted as a 1:1:1 ternary complex of the metal ion, metallacrown, and anion. The Li+/Na+ extraction selectivity is anion dependent and highest with [pic]-. Therefore, we devised an extraction-spectrophotometric determination method for Li+ in saline water based on the extraction of Li+ using the metallacrown and [pic]- for high selectivity and subsequent replacement of [pic]- in the extracted species with [TBPE]- for high sensitivity...
2018: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
B Kalyana Babu, Salej Sood, Dinesh Kumar, Anjeli Joshi, A Pattanayak, Lakshmi Kant, H D Upadhyaya
Barnyard millet (Echinochloa spp.) is an important crop from nutritional point of view, nevertheless, the genetic information is very scarce. In the present investigation, rice and finger millet genomic SSRs were used for assessing cross transferability, identification of polymorphic markers, syntenic regions, genetic diversity and population structure analysis of barnyard millet genotypes. We observed 100% cross transferability for finger millet SSRs, of which 91% were polymorphic, while 71% of rice markers were cross transferable with 48% polymorphic out of them...
February 2018: 3 Biotech
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