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Josip Crnjac, Petar Ozretić, Siniša Merkaš, Martina Ratko, Mateja Lozančić, Marina Korolija, Maja Popović, Gordan Mršić
X chromosome STR typing has emerged recently as a powerful tool, complementary to autosomal STR typing, in solving complex forensic and missing person cases. Investigator® Argus X-12 is a commercial product that allows co-amplification of 12 X chromosomal markers belonging to four linkage groups (LGs). In this study, we analyzed by capillary electrophoresis blood samples from 100 females and 102 males from a population of northern Croatia. Statistical analysis included calculation of allele and haplotype frequencies, as well as forensic parameters...
October 20, 2016: Genetics and Molecular Biology
Koichiro Saito, Ichiro Tanabe, Tetsu Tatsuma
Plasmon-induced charge separation (PICS) at the interface between a plasmonic nanoparticle and semiconductor is now widely used for photovoltaics and photocatalysis. Here we take advantage of PICS for site-selective nanoetching of silver nanocubes on TiO2 beyond the diffraction limit. A silver nanocube exhibits two resonance modes localized at the top and bottom of the nanocube (distal and proximal modes, respectively) when it is placed on TiO2. We achieved selective etching at the top and the bottom of the nanocubes by PICS based on the distal and proximal modes, respectively...
October 21, 2016: Journal of Physical Chemistry Letters
Dana Ahnood, Savitha Madhusudhan, Marie D Tsaloumas, Nadia K Waheed, Pearse A Keane, Alastair K Denniston
Punctate Inner Choroidopathy (PIC), an idiopathic inflammatory multifocal chorioretinopathy that predominantly affects young myopic women, appears to be relatively rare, but there is limited data to support accurate estimates of prevalence, and it is likely that the condition is under-diagnosed. The etiological relationship between PIC and other conditions within the 'white dot syndromes' group remains uncertain. We, like others, would suggest that PIC and multifocal choroiditis with panuveitis (MCP) represent a single disease process that is modified by host factors (including host immunoregulation) to cause the range of clinical phenotypes seen...
October 14, 2016: Survey of Ophthalmology
Jian-Dong Li, Ai-Yuan Cheng, Yan-Li Huo, Jie Fan, Yu-Ping Zhang, Zhi-Qin Fang, Hong-Sheng Sun, Wei Peng, Jin-Shun Zhang, Hai-Ping Wang, Bao-Jian Xue
Heart failure (HF) is characterized by cardiac dysfunction along with autonomic unbalance that is associated with increased renin-angiotensin system (RAS) activity and elevated levels of proinflammatory cytokines (PICs). Renal denervation (RD) has been shown to improve cardiac function in HF, but the protective mechanisms remain unclear. The present study tested the hypothesis that RD ameliorates isoproterenol- (ISO-) induced HF through regulation of brain RAS and PICs. Chronic ISO infusion resulted in remarked decrease in blood pressure (BP) and increase in heart rate and cardiac dysfunction, which was accompanied by increased BP variability and decreased baroreflex sensitivity and HR variability...
2016: Oxidative Medicine and Cellular Longevity
Tainã Rapp Py-Daniel, Anderson Kennedy Soares De-Lima, Fabiano Campos Lima, Aline Pic-Taylor, Osmindo Rodrigues Pires Junior, Antonio Sebben
The mouse, chicken, African clawed frog and zebrafish are considered "model organisms" due to their extensive embryological and genetic characterization. However they are far from representative of known diversity, impairing phylogenetic analyses of developmental patterns. Since squamates have historically received limited attention in developmental studies, we here describe the developmental sequence for Tropidurus torquatus, and provide the first post-ovipositional developmental series for the lizard family Tropiduridae...
October 14, 2016: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
Yurong Du, Xiaoyan Zou, Yongtao Xu, Xinyi Guo, Shuang Li, Xuze Zhang, Mengyu Su, Jianbin Ma, Songchang Guo
The Tibetan antelope (chiru, Pantholops hodgsoni) is one of the most endangered mammals native to the Qinghai-Tibetan Plateau. The population size has rapidly declined over the last century due to illegal hunting and habitat damage. In the past 10 years, the population has reportedly been expanding due to conservation efforts. Several lines of evidence suggest that the Tibetan antelope has undergone a demographic bottleneck. However, the consequences of the bottleneck on genetic diversity and the post-bottleneck genetic recovery remain unknown...
October 14, 2016: Scientific Reports
Chunyan Yi, Chunyan Zheng, Ling Zeng, Yijuan Xu
BACKGROUND: Geographic isolation is an important factor that limit species dispersal and thereby affects genetic diversity. Because islands are often small and surrounded by a natural water barrier to dispersal, they generally form discrete isolated habitats. Therefore, islands may play a key role in the distribution of the genetic diversity of insects, including flies. RESULTS: To characterize the genetic structure of island populations of Bactrocera dorsalis, we analyzed a dataset containing both microsatellite and mtDNA loci of B...
October 13, 2016: BMC Ecology
Ferhat Canbay, Vecdi Emre Levent, Gorkem Serbes, H Fatih Ugurdag, Sezer Goren, Nizamettin Aydin
The authors aimed to develop an application for producing different architectures to implement dual tree complex wavelet transform (DTCWT) having near shift-invariance property. To obtain a low-cost and portable solution for implementing the DTCWT in multi-channel real-time applications, various embedded-system approaches are realised. For comparison, the DTCWT was implemented in C language on a personal computer and on a PIC microcontroller. However, in the former approach portability and in the latter desired speed performance properties cannot be achieved...
September 2016: Healthcare Technology Letters
Barbara Terelak-Borys, Katarzyna Zagajewska, Irmina Jankowska-Lech, Piotr Tesla, Iwona Grabska-Liberek
PURPOSE: The purpose of this study was to describe a combination treatment for choroidal neovascular (CNV) membrane, secondary to punctate inner choroidopathy (PIC). PATIENT AND METHODS: A 44-year-old female patient was diagnosed with PIC complicated by the development of recurrent juxtafoveal neovascular membrane. The treatment included a sequence of monotherapy regimens: systemic steroid therapy, photodynamic therapy, and intravitreal injections of vascular endothelial growth factor (VEGF) inhibitor (anti-VEGF)...
2016: Therapeutics and Clinical Risk Management
G Pic, J E Terrier, B Ozenne, N Morel-Journel, P Paparel, A Ruffion
INTRODUCTION: Stress urinary incontinence (SUI) is a degradation of the quality of life factor in the consequences of radical prostatectomy. Artificial urinary sphincter (AUS) is the standard treatment. Screening and preoperative treatment of anastomotic strictures (AS) is an essential step for the success of the intervention. The objective of the study was to assess the impact of AS on the results of AUA. METHODS: We retrospectively studied 147 AUS settlements from 2005 to 2013 in the urology department of the Centre Hospitalier Lyon by three operators...
October 7, 2016: Progrès en Urologie
Yeqian Huang, Nayef A Alzahrani, Winston Liauw, Thamer B Traiki, David L Morris
BACKGROUND: There is little evidence for the use of early postoperative intraperitoneal chemotherapy (EPIC) in patients with low-grade appendiceal mucinous neoplasms (LAMNs) with pseudomyxoma peritonei (PMP). This study aims to assess the outcomes regarding the use of EPIC in a large cohort of patients with LAMNs with PMP uniformly treated by cytoreductive surgery (CRS) and perioperative intraperitoneal chemotherapy (PIC), all of whom received hyperthermic intraperitoneal chemotherapy (HIPEC), and most of whom also received EPIC...
October 7, 2016: Annals of Surgical Oncology
Elizabeth DeLaney, Donal S Luse
Pausing during the earliest stage of transcript elongation by RNA polymerase II (Pol II) is a nearly universal control point in metazoan gene expression. The substoichiometric Pol II subunit Gdown1 facilitates promoter proximal pausing in vitro in extract-based transcription reactions, out-competes the initiation/elongation factor TFIIF for binding to free Pol II and co-localizes with paused Pol II in vivo. However, we have shown that Gdown1 cannot functionally associate with the Pol II preinitiation complex (PIC), which contains TFIIF...
2016: PloS One
Jonathon D Brzezinski, Roland Felkner, Apexa Modi, Mengdan Liu, Monica J Roth
: The p12 protein of murine leukemia virus (MLV) Gag is associated with the preintegration complex (PIC), and mutants of p12 (PM14) exhibit defects in nuclear entry/retention. Mutants of the phosphorylated serine-61 also have reported defects in the early life cycle. Here we show that a phosphorylated peptide motif derived from human papillomavirus 8 (HPV 8), the E2 hinge region240-255, can functionally replace the main phosphorylated motif of MLV p12 and can rescue the viral titer of a lethal p12-PM14 mutant...
October 5, 2016: Journal of Virology
Jonathon D Brzezinski, Apexa Modi, Mengdan Liu, Monica J Roth
: Murine Leukemia Virus (MLV) p12, encoded within Gag, binds the viral preintegration complex (PIC) to the mitotic chromatin. This acts to anchor the viral PIC in the nucleus as the nuclear envelope reforms post-mitosis. Mutations within the p12 C-terminus (p12 PM13-15) block early stages in viral replication. Within the p12 PM13 region (p12 60PSPMA65), our studies indicated that chromatin tethering is not detected when the wild type p12 protein (M63) was expressed as a GFP fusion, however, constructs bearing p12-I63 were tethered...
October 5, 2016: Journal of Virology
Moran Golan, Valeria Feinshtein, Ayelet David
The key for successful gene silencing is to design a safe and efficient siRNA delivery system for the transfer of therapeutic nucleic acids into the target cells. Here, we describe the design of hydrophilic N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer displaying multiple copies of octaarginine (R8) and its use in promoting the effective delivery of small interfering RNA (siRNA) molecules intracellularly. Fluorescein-5-isothiocyanate (FITC)-labeled HPMA copolymer-bound R8 (P-R8-FITC) was synthesized with increasing R8 molar ratios (4 to 9...
October 1, 2016: European Journal of Pharmaceutics and Biopharmaceutics
Lesley A Ballantyne, Christine L Lambkin, Xin Luan, Yuvarin Boontop, Sorasak Nak-Eiam, Suttisan Pimpasalee, Sommyot Silalom, Anchana Thancharoen
Sclerotia Ballantyne gen. nov. is established for seven species. Sclerotia aquatilis (Thancharoen, 2007), Scl. brahmina (Bourgeois, 1890), Scl. carinata (Gorham, 1880), Scl. flavida (Hope, 1845), Scl. seriata (Olivier, 1891), and Scl. substriata (Gorham, 1880) are transferred from Luciola Laporte. Sclerotia fui sp. nov. from China is described as new. Luciola cingulata Olivier, 1885 is synonymised with Luciola substriata Gorham. Luciola formosana Pic, 1916 is removed from synonymy with Luciola substriata and newly synonymised with Luciola flavida (Hope)...
September 23, 2016: Zootaxa
M K Arevalo, J C Prieto, N Cost, G Nuss, B J Brown, L A Baker
INTRODUCTION: Symptomatic pediatric ureterocele has diverse manifestations, making evidence-based management impractical. Thus, detailed visualization of ureterocele anatomy prior to first surgical incision is invaluable. Retrograde ureterocelogram (RUC) is a simple, underutilized radiologic technique that can be performed during cystoscopy. This study sought to determine whether RUC changes surgical management by more accurately depicting the complex ureteral and ureterocele anatomy, compared with renal ultrasound (US) and voiding cystourethrography (VCUG)...
September 17, 2016: Journal of Pediatric Urology
J A Feldpausch, R G Amachawadi, M D Tokach, H M Scott, T G Nagaraja, S S Dritz, R D Goodband, J C Woodworth, J M DeRouchey
A total of 480 pigs (PIC 327 × 1050; initially 48.7 ± 2.3 kg) were used to determine the interactive effects of supplemental Cu, Zn, and ractopamine HCl (RAC) on finishing pig growth performance, carcass characteristics, and antimicrobial susceptibility of enteric bacteria. Treatments were arranged in a 2 × 2 × 2 factorial with the main effects of added Cu (CuSO; 0 vs. 125 mg/kg Cu), Zn (ZnO; 0 vs. 150 mg/kg Zn), and RAC (0 vs. 10 mg/kg during the last 28 d prior to marketing). All diets contained 11 mg/kg Cu and 73 mg/kg Zn from the trace mineral premix...
August 2016: Journal of Animal Science
J A De Jong, J M DeRouchey, M D Tokach, S S Dritz, R D Goodband, C B Paulk, J C Woodworth, C K Jones, C R Stark
Two experiments were conducted to test the effects of wheat source and particle size in meal and pelleted diets on finishing pig performance, carcass characteristics, and diet digestibility. In Exp. 1, pigs (PIC 327 × 1050; = 288; initially 43.8 kg BW) were balanced by initial BW and randomly allotted to 1 of 3 treatments with 8 pigs per pen (4 barrows and 4 gilts) and 12 pens per treatment. The 3 dietary treatments were hard red winter wheat ground with a hammer mill to 728, 579, or 326 μm, respectively...
August 2016: Journal of Animal Science
Linbo Yan, C Jim Lim, Guangxi Yue, Boshu He, John R Grace
A user-defined solver integrating the solid-gas surface reactions and the multi-phase particle-in-cell (MP-PIC) approach is built based on the OpenFOAM software. The solver is tested against experiments. Then, biomass-steam gasification in a dual fluidized bed (DFB) gasifier is preliminarily predicted. It is found that the predictions agree well with the experimental results. The bed material circulation loop in the DFB can form automatically and the bed height is about 1m. The voidage gradually increases along the height of the bed zone in the bubbling fluidized bed (BFB) of the DFB...
December 2016: Bioresource Technology
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