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https://www.readbyqxmd.com/read/28739580/structural-insights-into-transcription-initiation-by-yeast-rna-polymerase-i
#1
Yashar Sadian, Lucas Tafur, Jan Kosinski, Arjen J Jakobi, Rene Wetzel, Katarzyna Buczak, Wim Jh Hagen, Martin Beck, Carsten Sachse, Christoph W Müller
In eukaryotic cells, RNA polymerase I (Pol I) synthesizes precursor ribosomal RNA (pre-rRNA) that is subsequently processed into mature rRNA. To initiate transcription, Pol I requires the assembly of a multi-subunit pre-initiation complex (PIC) at the ribosomal RNA promoter. In yeast, the minimal PIC includes Pol I, the transcription factor Rrn3, and Core Factor (CF) composed of subunits Rrn6, Rrn7, and Rrn11. Here, we present the cryo-EM structure of the 18-subunit yeast Pol I PIC bound to a transcription scaffold...
July 24, 2017: EMBO Journal
https://www.readbyqxmd.com/read/28732469/microsatellite-marker-development-by-partial-sequencing-of-the-sour-passion-fruit-genome-passiflora-edulis-sims
#2
Susan Araya, Alexandre M Martins, Nilton T V Junqueira, Ana Maria Costa, Fábio G Faleiro, Márcio E Ferreira
BACKGROUND: The Passiflora genus comprises hundreds of wild and cultivated species of passion fruit used for food, industrial, ornamental and medicinal purposes. Efforts to develop genomic tools for genetic analysis of P. edulis, the most important commercial Passiflora species, are still incipient. In spite of many recognized applications of microsatellite markers in genetics and breeding, their availability for passion fruit research remains restricted. Microsatellite markers in P. edulis are usually limited in number, show reduced polymorphism, and are mostly based on compound or imperfect repeats...
July 21, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28729914/effects-of-mtor-on-neurological-deficits-after-transient-global-ischemia
#3
Jihong Xing, Jian Lu
Mammalian target of rapamycin (mTOR) is a serine/threonine protein kinase and activation of its signal pathway plays an important role in regulating protein growth and synthesis as well as cell proliferation and survival. In the present study, we examined the contribution of mTOR and its downstream products to brain injuries and neurological deficiencies after cardiac arrest (CA) induced-transient global ischemia. CA was induced by asphyxia followed by cardiopulmonary resuscitation (CPR) in rats. Our results showed that expression of p-mTOR, mTOR-mediated phosphorylation of 4E-binding protein 4 (4E-BP1) and p70 ribosomal S6 protein kinase 1 (S6K1) pathways were amplified in CA rats compared to their controls...
2017: Translational Neuroscience
https://www.readbyqxmd.com/read/28729554/comparison-of-traditional-and-new-generation-dna-markers-declares-high-genetic-diversity-and-differentiated-population-structure-of-wild-almond-species
#4
Karim Sorkheh, Mehrana Koohi Dehkordi, Sezai Ercisli, Attila Hegedus, Júlia Halász
Wild almond species as sources of genetic variation may have crucial importance in breeding. A total of 389 accessions of 18 species have been analysed using inter-retrotransposon amplified polymorphism (IRAP), retrotransposon-microsatellite amplified polymorphism (REMAP), sequence-specific amplification polymorphism (S-SAP), amplified fragment length polymorphism (AFLP), inter simple sequence repeat (ISSR) and simple sequence repeats (SSR). Retrotransposon markers indicated the presence and movement of some Ty3-gypsy and Ty1-copia-elements in almond genome...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28727001/analysis-of-genetic-diversity-of-chinese-dairy-goats-via-microsatellite-markers
#5
G Z Wang, S S Chen, T L Chao, Z B Ji, L Hou, Z J Qin, J M Wang
In this study, 15 polymorphic microsatellite markers were used to analyze the genetic structure and phylogenetic relationships of 6 dairy goat breeds in China, including 4 native developed breeds and 2 introduced breeds. The results showed that a total of 172 alleles were detected in 347 samples of the dairy goat breeds included in this study. The mean number of effective alleles per locus was 4.92. Except for BMS0812, all of the remaining microsatellite loci were highly polymorphic (polymorphism information content [PIC] > 0...
May 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28726875/time-resolved-spectroscopic-analysis-of-the-light-energy-harvesting-mechanism-in-carbazole-dendrimers-with-a-blue-phosphorescent-ir-complex-core
#6
Yang-Jin Cho, So-Yoen Kim, Mi Rang Son, Ho-Jin Son, Dae Won Cho, Sang Ook Kang
In order to investigate the light-energy harvesting mechanism, a series of dendrimers with a heteroleptic iridium(iii) complex core, [Ir(dmb)2(pic-Czn)] (Gn: n = 1, 2, and 3), with 2,6-difluoro-3-(4-methylpyridin-2-yl)benzonitrile (dmb) as the cyclometallating ligand and 3-hydroxypicolinate (pic) as the ancillary ligand, connected to carbazole-based dendrons (Czn: n = 2, 4, and 8) was synthesized. The Ir centred complex [Ir(dmb)2(pic-OCH3), G0] shows a blue emission at <500 nm, which is assigned to metal-to-ligand charge-transfer ((3)MLCT) phosphorescence...
July 20, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28725854/improving-the-patient-experience-by-implementing-an-icu-diary-for-those-at-risk-of-post-intensive-care-syndrome
#7
K Taylor A Blair, Sarah D Eccleston, Hannah M Binder, Mary S McCarthy
The critical care literature in the US has recently brought attention to the impact an ICU experience can have long after the patient survives critical illness, particularly if delirium was present. Current recommendations to mitigate post-intensive care syndrome (PICS) are embedded in patient and family-centered care and aim to promote family presence in the ICU, provide support for decision-making, and enhance communication with the health-care team. Evidence-based interventions are few in number but include use of an ICU diary to minimize the psychological and emotional sequelae affecting patients and family members in the months following the ICU stay...
March 2017: Journal of patient experience
https://www.readbyqxmd.com/read/28722044/tripartite-polyionic-complex-pic-micelles-as-non-viral-vectors-for-mesenchymal-stem-cell-sirna-transfection
#8
Sophie Raisin, Marie Morille, Claire Bony, Danièle Noël, Jean-Marie Devoisselle, Emmanuel Belamie
In the context of regenerative medicine, the use of RNA interference mechanisms has already proven its efficiency in targeting specific gene expression with the aim of enhancing, accelerating or, more generally, directing stem cell differentiation. However, achievement of good transfection levels requires the use of a gene vector. For in vivo applications, synthetic vectors are an interesting option to avoid possible issues associated with viral vectors (safety, production costs, etc.). Herein, we report on the design of tripartite polyionic complex micelles as original non-viral polymeric vectors suited for mesenchymal stem cell transfection with siRNA...
July 19, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28721340/post-intensive-care-syndrome-an-overview
#9
Gautam Rawal, Sankalp Yadav, Raj Kumar
Survival of critically unwell patients has improved in the last decade due to advances in critical care medicine. Some of these survivors develop cognitive, psychiatric and /or physical disability after treatment in intensive care unit (ICU), which is now recognized as post intensive care syndrome (PICS). Given the limited awareness about PICS in the medical faculty this aspect is often overlooked which may lead to reduced quality of life and cause a lot of suffering of these patients and their families. Efforts should be directed towards preventing PICS by minimizing sedation and early mobilization during ICU...
June 2017: Journal of Translational Internal Medicine
https://www.readbyqxmd.com/read/28716375/aging-and-post-intensive-care-syndrome-a-critical-need-for-geriatric-psychiatry
#10
REVIEW
Sophia Wang, Duane Allen, You Na Kheir, Noll Campbell, Babar Khan
Because of the aging of the intensive care unit (ICU) population and an improvement in survival rates after ICU hospitalization, an increasing number of older adults are suffering from long-term impairments because of critical illness, known as post-intensive care syndrome (PICS). This article focuses on PICS-related cognitive, psychological, and physical impairments and the impact of ICU hospitalization on families and caregivers. The authors also describe innovative models of care for PICS and what roles geriatric psychiatrists could play in the future of this rapidly growing population...
June 1, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28716064/informed-consent-in-randomised-controlled-trials-development-and-preliminary-evaluation-of-a-measure-of-participatory-and-informed-consent-pic
#11
Julia Wade, Daisy Elliott, Kerry N L Avery, Daisy Gaunt, Grace J Young, Rebecca Barnes, Sangeetha Paramasivan, W Bruce Campbell, Jane M Blazeby, Alison J Birtle, Rob C Stein, David J Beard, Alison W Halliday, Jenny L Donovan
BACKGROUND: Informed consent (IC) is an ethical and legal prerequisite for trial participation, yet current approaches evaluating participant understanding for IC during recruitment lack consistency. No validated measure has been identified that evaluates participant understanding for IC based on their contributions during consent interactions. This paper outlines the development and formative evaluation of the Participatory and Informed Consent (PIC) measure for application to recorded recruitment appointments...
July 17, 2017: Trials
https://www.readbyqxmd.com/read/28714939/systematics-of-the-ceracis-furcifer-species-group-coleoptera-ciidae-the-specialized-consumers-of-the-blood-red-bracket-fungus-pycnoporus-sanguineus
#12
Italo S C Pecci-Maddalena, Cristiano Lopes-Andrade
The Ceracis furcifer species-group (Coleoptera: Ciidae) originally comprised nine species names: Ceracis cornifer (Mellié, 1849); C. cylindricus (Brèthes, 1922); C. furcifer Mellié, 1849; C. hastifer (Mellié, 1849); C. monocerus Lawrence, 1967; C. ruficornis Pic, 1916; C. simplicicornis (Pic, 1916); C. semipallidus Pic, 1922 and C. unicornis Gorham, 1898. Ceracis semipallidus was synonymised with C. furcifer and then no further changes were made to the composition of the group. Here, we provide a taxonomic revision of the Ceracis furcifer species-group and new data on the geographic distribution and host fungi of the included species...
July 17, 2017: Insects
https://www.readbyqxmd.com/read/28710987/the-long-term-quality-of-life-in-patients-with-persistent-inflammation-immunosuppression-and-catabolism-syndrome-after-severe-acute-pancreatitis-a-retrospective-cohort-study
#13
Na Yang, Baiqiang Li, Bo Ye, Lu Ke, Faxi Chen, Guotao Lu, Fangfang Jiang, Zhihui Tong, Jieshou Li, Weiqin Li
PURPOSE: To explore clinical characteristics and long-term quality of life (QOL) in severe acute pancreatitis (SAP) patients with persistent inflammation-immunosuppression and catabolism syndrome (PICS). MATERIALS AND METHODS: SAP patients admitted to ICU were eligible for the retrospective cohort study if they needed prolonged intensive care (>14days). Post-ICU QOL was assessed by a questionnaire, including 36-item Short Form Health Survey (SF-36) and record of re-work in a long-term follow-up...
July 8, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28708408/comprehension-of-the-effect-of-a-hydroxyl-group-in-ancillary-ligand-on-phosphorescent-property-for-heteroleptic-ir-iii-complexes-a-computational-study-using-quantitative-prediction
#14
Xiaolin Wang, Huiqing Yang, Yaping Wen, Li Wang, Junfeng Li, Jinglai Zhang
A new Ir(III) complex (dfpypya)2Ir(pic-OH) (2) is theoretically designed by introduction of a simple hydroxyl group into the ancillary ligand on the basis of (dfpypya)2Ir(pic) (1) with the aim to get the high-efficiency and stable blue-emitting phosphors, where dfpypya is 3-methyl-6-(2',4'-difluoro-pyridinato)pyridazine, pic is picolinate, and pic-OH is 3-hydroxypicolinic acid. The other configuration (dfpypya)2Ir(pic-OH)' (3) is also investigated to compare with 2. The difference between 2 and 3 is whether the intramolecular hydrogen bond is formed in the (dfpypya)2Ir(pic-OH)...
July 14, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28704940/effects-of-protein-iron-complex-concentrate-supplementation-on-iron-metabolism-oxidative-and-immune-status-in-preweaning-calves
#15
Robert Kupczyński, Michał Bednarski, Kinga Śpitalniak, Krystyna Pogoda-Sewerniak
The objective of this study was to determine the effects of feeding protein-iron complex (PIC) on productive performance and indicators of iron metabolism, hematology parameters, antioxidant and immune status during first 35 days of a calf's life. Preparation of the complex involved enzymatic hydrolysis of milk casein (serine protease from Yarrowia lipolytica yeast). Iron chloride was then added to the hydrolyzate and lyophilizate. Calves were divided into treated groups: LFe (low iron dose) 10 g/day calf of protein-iron complex, HFe (height iron dose) 20 g/day calf, and control group...
July 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28699889/evidence-that-mediator-is-essential-for-pol-ii-transcription-but-is-not-a-required-component-of-the-preinitiation-complex-in-vivo
#16
Natalia Petrenko, Yi Jin, Koon Ho Wong, Kevin Struhl
The Mediator complex has been described as a general transcription factor, but it is unclear if it is essential for Pol II transcription and/or is a required component of the preinitiation complex (PIC) in vivo. Here, we show that depletion of individual subunits, even those essential for cell growth, causes a general but only modest decrease in transcription. In contrast, simultaneous depletion of all Mediator modules causes a drastic decrease in transcription. Depletion of head or middle subunits, but not tail subunits, causes a downstream shift in the Pol II occupancy profile, suggesting that Mediator at the core promoter inhibits promoter escape...
July 12, 2017: ELife
https://www.readbyqxmd.com/read/28695759/diffusion-tensor-imaging-findings-suggestive-of-white-matter-alterations-in-a-canine-model-of-mucopolysaccharidosis-type-i
#17
Dana M Middleton, Jonathan Y Li, Steven D Chen, Leonard E White, Patricia Dickson, N Matthew Ellinwood, James M Provenzale
Purpose We investigated fractional anisotropy (FA) and radial diffusivity (RD) in a canine model of mucopolysaccharidosis (MPS). We hypothesized that canines affected with MPS would exhibit decreased FA and increased RD values when compared to unaffected canines, a trend that has been previously described in humans with white matter diseases. Methods Four unaffected canines and two canines with MPS were euthanized at 18 weeks of age. Their brains were imaged using high-resolution diffusion tensor imaging (DTI) on a 7T small-animal magnetic resonance imaging system...
January 1, 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28695625/water-oxidation-by-in-situ-generated-ruii-oh2-ncnhco-pic-2
#18
Wei Su, Kui Zhou, Fanglin Cai, Cheng Chen, Bibimaryam Mousavi, Somboon Chaemchuen, Francis Verpoort
: A dinuclear ruthenium complex [RuII(NCNHCO)(pic)2]22+ (2) was firstly prepared and characterized spectroscopically and electrochemically. Instead of the conventional ligand exchange, complex 2 dissociates in-situ to afford two single-site Ru aqua complexes, [RuII(OH2)(NCNHCO)(pic)2]+, which mediates water oxidation through proton-coupled electron transfer events. In electrokinetic studies, complex 2 demonstrated a TOF of 150.3 s-1 comparable to those state-of-the-art catalysts at neutral conditions. TONs of 2173 and 217 were attained in chemical and photochemical water oxidation when 2 was used as a catalyst, exhibiting good stability...
July 11, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28684585/impact-of-the-localization-of-dendritic-calcium-persistent-inward-current-on-the-input-output-properties-of-spinal-motoneuron-pool-a-computational-study
#19
Hojeong Kim
The goal of this study is to investigate how the dendritic Ca-PIC location influences nonlinear input-output properties and depends on the type of motoneurons across the motoneuron pool. A model motoneuron pool consisting of 10 motoneurons was constructed using a recently developed two-compartment modeling approach that reflected key cell type-associated properties experimentally identified. The dendritic excitability and firing output depended systematically on both the PIC location and the motoneuron type...
July 6, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28678899/incidence-of-phlebitis-and-post-infusion-phlebitis-in-hospitalised-adults
#20
Janete de Souza Urbanetto, Franciele de Oliveira Minuto Muniz, Renata Martins da Silva, Ana Paula Christo de Freitas, Ana Paula Ribeiro de Oliveira, Jessica de Cassia Ramos Dos Santos
Objective: to determine the incidence of phlebitis during and after the use of peripheral intravenous catheter (PIC), and analyse the association of this complication with risk factors. Methods: cohort study with 165 adult patients admitted to a university hospital in Porto Alegre, totalling 447 accesses, from December 2014 to February 2015. Data were collected on a daily basis and analysed by means of descriptive and analytical statistics. Results: The incidence of phlebitis during PIC was 7...
June 29, 2017: Revista Gaúcha de Enfermagem
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