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https://www.readbyqxmd.com/read/28078868/minoxidil-dose-response-study-in-female-pattern-hair-loss-patients-determined-to-be-non-responders-to-5-topical-minoxidil
#1
J McCoy, A Goren, M Kovacevic, J Shapiro
Topical minoxidil is the only US FDA approved drug for the treatment of female pattern hair loss (FPHL). 5% minoxidil foam is only effective at re-growing hair in a minority of women (approximately 40%). Thus, the majority of FPHL patients remain untreated. Previously, we demonstrated that nonresponders to 5% minoxidil have low metabolism of minoxidil in hair follicles. As such, we hypothesized that increasing the dosage of topical minoxidil to low metabolizers would increase the number of responders without increasing the incidence of adverse events...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28073089/application-of-a-mitochondrial-dna-control-region-frequency-database-for-uk-domestic-cats
#2
Barbara Ottolini, Gurdeep Matharu Lall, Federico Sacchini, Mark A Jobling, Jon H Wetton
DNA variation in 402bp of the mitochondrial control region flanked by repeat sequences RS2 and RS3 was evaluated by Sanger sequencing in 152 English domestic cats, in order to determine the significance of matching DNA sequences between hairs found with a victim's body and the suspect's pet cat. Whilst 95% of English cats possessed one of the twelve globally widespread mitotypes, four new variants were observed, the most common of which (2% frequency) was shared with the evidential samples. No significant difference in mitotype frequency was seen between 32 individuals from the locality of the crime and 120 additional cats from the rest of England, suggesting a lack of local population structure...
December 21, 2016: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/28069640/sequence-variation-in-ppp1r13l-results-in-a-novel-form-of-cardio-cutaneous-syndrome
#3
Tzipora C Falik-Zaccai, Yiftah Barsheshet, Hanna Mandel, Meital Segev, Avraham Lorber, Shachaf Gelberg, Limor Kalfon, Shani Ben Haroush, Adel Shalata, Liat Gelernter-Yaniv, Sarah Chaim, Dorith Raviv Shay, Morad Khayat, Michal Werbner, Inbar Levi, Yishay Shoval, Galit Tal, Stavit Shalev, Eli Reuveni, Emily Avitan-Hersh, Eugene Vlodavsky, Liat Appl-Sarid, Dorit Goldsher, Reuven Bergman, Zvi Segal, Ora Bitterman-Deutsch, Orly Avni
Dilated cardiomyopathy (DCM) is a life-threatening disorder whose genetic basis is heterogeneous and mostly unknown. Five Arab Christian infants, aged 4-30 months from four families, were diagnosed with DCM associated with mild skin, teeth, and hair abnormalities. All passed away before age 3. A homozygous sequence variation creating a premature stop codon at PPP1R13L encoding the iASPP protein was identified in three infants and in the mother of the other two. Patients' fibroblasts and PPP1R13L-knocked down human fibroblasts presented higher expression levels of pro-inflammatory cytokine genes in response to lipopolysaccharide, as well as Ppp1r13l-knocked down murine cardiomyocytes and hearts of Ppp1r13l-deficient mice...
January 9, 2017: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/28063635/determination-of-cocaine-and-its-derivatives-in-hair-samples-by-liquid-phase-microextraction-lpme-and-gas-chromatography-mass-spectrometry-gc-ms
#4
A M F Pego, F L Roveri, R Y Kuninari, V Leyton, I D Miziara, M Yonamine
Hair testing is a recognized approach when it comes to accessing historical drug use. According to the World Drug Report of United Nations Office on Drugs and Crime (UNODC) 2015, Brazil is the largest cocaine (COC) market in South America. New analytical methodologies to detect crack/cocaine analytes in hair samples are highly desirable. Here, a method consisting of a liquid-phase microextraction (LPME) as a clean-up step, followed by gas chromatography-mass spectrometry (GC-MS) analysis has been proposed. The new validated method consisted of a washing step; an overnight incubation with methanol and a quick derivatization with butylchloroformate...
December 23, 2016: Forensic Science International
https://www.readbyqxmd.com/read/28063525/the-impact-of-skin-diseases-on-quality-of-life-a-multicenter-study
#5
G Sanclemente, C Burgos, J Nova, F Hernández, C González, M I Reyes, N Córdoba, Á Arévalo, E Meléndez, J Colmenares, S Ariza, G Hernández
INTRODUCTION: To date, no formal study has been published regarding how Colombian patients with skin disorders could be affected according to their perception of disease. OBJECTIVE: To determine the impact in quality of life of skin diseases in a Colombian population. METHODS: This multicenter study included patients with skin disease from almost the whole country. Individuals >18 years old; of any gender; with any skin disease and who signed informed consent, were included...
January 4, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28063329/determination-of-ethyl-glucuronide-in-human-hair-samples-a-multivariate-analysis-of-the-impact-of-extraction-conditions-on-quantitative-results
#6
Alexander Mueller, Hilke Jungen, Stefanie Iwersen-Bergmann, Lars Raduenz, Susanne Lezius, Hilke Andresen-Streichert
BACKGROUND: Ethyl glucuronide (EtG), a minor metabolite of ethanol, is used as a direct alcohol biomarker for the prolonged detection of ethanol consumption. Hair testing for EtG offers retrospective, long-term detection of ethanol exposition for several months and has gained practical importance in forensic and clinical toxicology. Since quantitative results of EtG hair testings are included in interpretations, a rugged quantitation of EtG in hair matrix is important. As generally known, sample preparation is critical in hair testing, and the scope of this study was on extraction of EtG from hair matrix...
December 19, 2016: Forensic Science International
https://www.readbyqxmd.com/read/28063236/reconstruction-of-travel-history-using-coupled-%C3%AE-18-o-and-87-sr-86-sr-measurements-of-hair
#7
Thuan H Chau, Brett J Tipple, Lihai Hu, Diego P Fernandez, Thure E Cerling, James R Ehleringer, Lesley A Chesson
RATIONALE: Oxygen isotope ratios (δ(18) O values) of hair largely reflect features of regional hydrology while strontium isotope ratios ((87) Sr/(86) Sr) are thought to reflect bedrock geology; combination of both isotope signatures may provide greater capacity for determining provenance and reconstructing travel history of an organism. To test this hypothesis, we compared the O-Sr isotope profiles of hair from domestic horses with known residency histories. METHODS: Tail hairs were collected from a pair of horses pastured together for a period of 16 months, one of which lived in a different location for the 8 months prior...
January 7, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28056375/evaluation-of-direct-and-indirect-ethanol-biomarkers-using-a-likelihood-ratio-approach-to-identify-chronic-alcohol-abusers-for-forensic-purposes
#8
Eugenio Alladio, Agnieszka Martyna, Alberto Salomone, Valentina Pirro, Marco Vincenti, Grzegorz Zadora
The detection of direct ethanol metabolites, such as ethyl glucuronide (EtG) and fatty acid ethyl esters (FAEEs), in scalp hair is considered the optimal strategy to effectively recognize chronic alcohol misuses by means of specific cut-offs suggested by the Society of Hair Testing. However, several factors (e.g. hair treatments) may alter the correlation between alcohol intake and biomarkers concentrations, possibly introducing bias in the interpretative process and conclusions. 125 subjects with various drinking habits were subjected to blood and hair sampling to determine indirect (e...
December 21, 2016: Forensic Science International
https://www.readbyqxmd.com/read/28049063/activity-of-pericampylus-glaucus-and-periglaucine-a-in-vitro-against-nasopharangeal-carcinoma-and-anti-inflammatory-activity
#9
Fiona Natalia Shipton, Teng-Jin Khoo, Md Shahadat Hossan, Christophe Wiart
ETHNOPHARMACOLOGICAL RELEVANCE: P. glaucus is a climbing plant found across Asia and used in traditional medicine to treat a number of conditions including splenomegaly, fever, cough, laryngitis, pulmonary disease, asthma, headache, hair loss, snake bite, boar bite, factures, boils, tumours, tetanus, rheumatic pain, itches and eclampsia. AIM OF THE STUDY: To test extracts of P. glaucus in a number of bioassays and determine the legitimacy of its traditional use...
December 31, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28046391/su-d-brc-07-system-design-for-a-3d-volumetric-scintillation-detector-using-scmos-cameras
#10
C Darne, D Robertson, F Alsanea, S Beddar
PURPOSE: The purpose of this project is to build a volumetric scintillation detector for quantitative imaging of 3D dose distributions of proton beams accurately in near real-time. METHODS: The liquid scintillator (LS) detector consists of a transparent acrylic tank (20×20×20 cm(3) ) filled with a liquid scintillator that when irradiated with protons generates scintillation light. To track rapid spatial and dose variations in spot scanning proton beams we used three scientific-complementary metal-oxide semiconductor (sCMOS) imagers (2560×2160 pixels)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046145/effects-of-cows-grazing-toxic-endophyte-infected-tall-fescue-or-novel-endophyte-infected-tall-fescue-in-late-gestation-on-cow-performance-reproduction-and-progeny-growth-performance-and-carcass-characteristics
#11
L M Shoup, L M Miller, M Srinivasan, F A Ireland, D W Shike
Very little is known regarding the effects of cow exposure to toxic ergot alkaloids in late gestation and the subsequent, long-term effects on progeny. Therefore, the objectives were to determine the effects of grazing toxic endophyte-infected tall fescue () or novel endophyte-infected tall fescue during late gestation on cow BW, BCS, hair coat score (HCS), respiration rates, milk production, and reproduction and on growth performance and carcass characteristics of progeny. Eighty gestating, Angus × Simmental cows (age = 6...
December 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/28036050/environmental-determinants-of-bronchial-asthma-among-saudi-school-children-in-southwestern-saudi-arabia
#12
Jobran M Alqahtani, Ahmed M Asaad, Nabil J Awadalla, Ahmed A Mahfouz
The aim here was to study the possible environmental and dietary determinants of asthma among school-aged children in Southwestern Saudi Arabia. In a cross-sectional study on a representative sample in Najran in Southwestern Saudi Arabia using an Arabic version of the modified ISAAC Phase III, parent-administered questionnaire data were collected. Skin prick tests (SPTs) were performed. The study included 1700 school children, out of them 468 (27.5%) were diagnosed with, cases of bronchial asthma and 20.8% (353) reported a 12-month nocturnal cough (as a proxy of severe asthma)...
December 28, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28030754/tonotopic-action-potential-tuning-of-maturing-auditory-neurons-through-endogenous-atp
#13
Saša Jovanovic, Tamara Radulovic, Claudio Coddou, Beatrice Dietz, Jana Nerlich, Stanko S Stojilkovic, Rudolf Rübsamen, Ivan Milenkovic
KEY POINTS: Following the genetically controlled formation of neuronal circuits, early firing activity guides the development of sensory maps in the auditory, visual and somatosensory system. However, it is not clear whether the activity of central auditory neurons is specifically regulated depending on the position within the sensory map. In the ventral cochlear nucleus, the first central station along the auditory pathway, we describe a mechanism through which paracrine ATP signalling enhances firing in a cell-specific and tonotopically-determined manner...
November 7, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/28030585/organ-of-corti-and-stria-vascularis-is-there-an-interdependence-for-survival
#14
Huizhan Liu, Yi Li, Lei Chen, Qian Zhang, Ning Pan, David H Nichols, Weiping J Zhang, Bernd Fritzsch, David Z Z He
Cochlear hair cells and the stria vascularis are critical for normal hearing. Hair cells transduce mechanical stimuli into electrical signals, whereas the stria is responsible for generating the endocochlear potential (EP), which is the driving force for hair cell mechanotransduction. We questioned whether hair cells and the stria interdepend for survival by using two mouse models. Atoh1 conditional knockout mice, which lose all hair cells within four weeks after birth, were used to determine whether the absence of hair cells would affect function and survival of stria...
2016: PloS One
https://www.readbyqxmd.com/read/28029293/pharmacokinetics-of-terbinafine-in-little-brown-myotis-myotis-lucifugus-infected-with-pseudogymnoascus-destructans
#15
Michael H Court, Alison H Robbins, Anne M Whitford, Erika V Beck, Flo S Tseng, DeeAnn M Reeder
OBJECTIVE To determine the pharmacokinetics of terbinafine in little brown myotis (Myotis lucifugus) infected with Pseudogymnoascus destructans. ANIMALS 123 bats from a P destructans-infected hibernation site in Virginia. PROCEDURES 3 bats were euthanized and necropsied to confirm the presence of P destructans within the population. The remaining 120 bats were systematically assigned to 6 groups (20 bats/group). Bats in each of 3 groups received 6, 20, or 60 mg of terbinafine/kg, SC, once daily for 10 days...
January 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28027553/effect-of-radiation-and-non-radiation-environmental-factors-on-children-hematopoietic-system
#16
V G Bebeshko, K M Bruslova, V V Stankevych, N M Tsvietkova, L O Lyashenko, S G Galkina, T I Pushkaryova, V I Kolos, O Ye Kuznetsova, L O Honchar, S M Yatsemyrskii, Y M Samson
OBJECTIVE: Identification of impact of radiation and non radiation environmental factors on development of hematopoi etic abnormalities in children and justification of criteria for the increased risk groups of hematologic diseases. MATERIALS AND METHODS: The results of clinical and hematological survey of 1465 children living in Kyiv, Zhytomyr and Chernihiv regions for the period from 2008 to 2014 were presented. There were 777 children with anemia, 466 with changes in hemogram, 191 with acute leukemia...
December 2016: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://www.readbyqxmd.com/read/28024997/androgen-receptor-ar-gene-cag-n-and-ggn-n-length-polymorphisms-and-symptoms-in-young-males-with-long-lasting-adverse-effects-after-finasteride-use-against-androgenic-alopecia
#17
Sabina Cauci, Giovanni Chiriacò, Erika Cecchin, Giuseppe Toffoli, Serena Xodo, Giuseppe Stinco, Carlo Trombetta
INTRODUCTION: Long-term adverse symptoms of men who used oral finasteride against androgenic alopecia have been recently described as post-finasteride syndrome (PFS). AIM: To determine whether (CAG)n-rs4045402 and (GGN)n-rs3138869 polymorphisms in the androgen receptor (AR) gene are implicated in PFS. METHODS: AR polymorphisms were studied according to PFS symptoms in 66 white participants (31.8% Italian, 28.8% American, and 39.4% other). MAIN OUTCOME MEASURES: Symptoms were investigated by an ad hoc 100-item questionnaire and the Arizona Sexual Experience Scale and Aging Male Symptom Scale (AMS)...
December 23, 2016: Sexual Medicine
https://www.readbyqxmd.com/read/28019657/the-melanoma-linked-redhead-mc1r-influences-dopaminergic-neuron-survival
#18
Xiqun Chen, Hongxiang Chen, Waijiao Cai, Michael Maguire, Bailiu Ya, Fuxing Zuo, Robert Logan, Hui Li, Katey Robinson, Charles R Vanderburg, Yang Yu, Yinsheng Wang, David E Fisher, Michael A Schwarzschild
OBJECTIVE: Individuals with Parkinson's disease are more likely to develop melanoma, and melanoma patients are reciprocally at higher risk of developing Parkinson's disease. Melanoma is strongly tied to red hair/fair skin, a phenotype of loss-of-function polymorphisms in the MC1R (melanocortin 1 receptor) gene. Loss-of-function variants of MC1R have also been linked to increased risk of Parkinson's disease. The present study is to investigate the role of MC1R in dopaminergic neurons in vivo...
December 26, 2016: Annals of Neurology
https://www.readbyqxmd.com/read/28018728/phoebe-a-method-for-real-time-mapping-of-optodes-scalp-coupling-in-functional-near-infrared-spectroscopy
#19
Luca Pollonini, Heather Bortfeld, John S Oghalai
Recent functional near-infrared spectroscopy (fNIRS) instrumentation encompasses several dozen of optodes to enable reconstructing a hemodynamic image of the entire cerebral cortex. Despite its potential clinical applicability, widespread use of fNIRS with human subjects is currently limited by unresolved issues, namely the collection from the entirety of optical channels of signals with a signal-to-noise ratio (SNR) sufficient to carry out a reliable estimation of cortical hemodynamics, and the considerable amount of time that placing numerous optodes take with individuals for whom achieving good optical coupling to the scalp is difficult due to thick or dark hair...
December 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/28009336/hypocortisolism-and-preterm-birth
#20
S D Karakash, N Tschankoshvili, J Weedon, R M Schwartz, C Kirschbaum, H Minkoff
OBJECTIVE: We sought to determine whether hypocortisolism is associated with preterm birth, using hair cortisol as a marker of long term hypothalamic-pituitary-adrenal axis activity. STUDY DESIGN: In a prospective, matched, case-control study, 29 women who had a preterm birth at 24-36w5d gestation were compared to 29 women who delivered at term, matched for maternal age, gestational age, and ethnicity. Cases' samples were collected within 72 h of preterm birth and controls at the same gestational age as the corresponding case...
2016: Journal of Neonatal-perinatal Medicine
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