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https://www.readbyqxmd.com/read/28528395/enhancing-hair-growth-in-male-androgenetic-alopecia-by-a-combination-of-fractional-co2-laser-therapy-and-hair-growth-factors
#1
Yue Huang, Fenglin Zhuo, Linfeng Li
Laser therapy and growth factors have been used as alternative treatments for male androgenetic alopecia (MAA). The aim of this study is to determine the efficacy and safety of hair growth factors alone or combined with ablative carbon dioxide (CO2) fractional laser therapy in MAA. Twenty-eight men were enrolled in this randomized half-split study based on a left-head to right-head pattern. Fractional CO2 laser treatment was unilaterally performed; hair growth factors were bilaterally applied. Six sessions with 2-week intervals were performed...
May 21, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28521190/simultaneous-determination-of-bisphenol-a-and-estrogens-in-hair-samples-by-liquid-chromatography-electrospray-tandem-mass-spectrometry
#2
Chaelin Lee, Chong Hyeak Kim, Sunghwan Kim, Sung-Hee Cho
Bisphenol A (BPA), an endocrine disrupter, is widely used to make chemicals for polycarbonate, plastics, beverage containers, epoxy resins, and cash register receipts. BPA is one of the known xenoestrogens, which have weak estrogenic activity and cause obesity, diabetes, breast cancer, and reproductive disorders. Even though the concentration level of metabolomes in hair is usually lower than that in urine and blood, there are several reasons why we chose to use hair samples. First, the sampling procedure of hairs is simple...
May 11, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28512199/dominant-negative-sox18-function-inhibits-dermal-papilla-maturation-and-differentiation-in-all-murine-hair-types
#3
Rehan Villani, Samantha Hodgson, Julien Legrand, Jessica Greaney, Ho Yi Wong, Cathy Pichol-Thievend, Christelle Adolphe, Brandon Wainwight, Mathias Francois, Kiarash Khosrotehrani
SOX family proteins SOX2 and SOX18 have been reported as being essential in determining hair follicle type; however, the role they play during development remains unclear. Here, we demonstrate that Sox18 regulates the normal differentiation of the dermal papilla of all hair types. In guard (primary) hair dermal condensate (DC) cells, we identified transient Sox18 in addition to SOX2 expression at E14.5, which allowed fate tracing of primary DC cells until birth. Similarly, expression of Sox18 was detected in the DC cells of secondary hairs at E16...
May 15, 2017: Development
https://www.readbyqxmd.com/read/28510613/preliminary-report-on-%C3%AE-casein-gene-met183qval183-polymorphism-in-romanian-indigenous-zackel-sheep-breeds
#4
Szilvia Kusza, Daniela Elena Ilie, Maria Sauer, Ioan-Walter Sauer, Dinu Gavojdian
Genetic polymorphisms of the milk protein genes are important because of their effects on quantitative traits and technological properties of milk manufacturing. In the present study we identified the polymorphism of the beta-casein gene in two local sheep breeds (Racka n=98 and Turcana n=111) in Romania. The most studied variants at the ovine beta-casein (CSN2) locus are: A and G variants. Genomic DNA was extracted from hair follicles and beta-casein genotypes were determined by the rapid TaqMan (Applied Biosystems, USA) genotyping assay...
May 17, 2017: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/28508256/the-role-of-micronutrients-in-alopecia-areata-a-review
#5
REVIEW
Jordan M Thompson, Mehwish A Mirza, Min Kyung Park, Abrar A Qureshi, Eunyoung Cho
Alopecia areata (AA) is a common, non-scarring form of hair loss caused by immune-mediated attack of the hair follicle. As with other immune-mediated diseases, a complex interplay between environment and genetics is thought to lead to the development of AA. Deficiency of micronutrients such as vitamins and minerals may represent a modifiable risk factor associated with development of AA. Given the role of these micronutrients in normal hair follicle development and in immune cell function, a growing number of investigations have sought to determine whether serum levels of these nutrients might differ in AA patients, and whether supplementation of these nutrients might represent a therapeutic option for AA...
May 15, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28506719/two-fatalities-associated-with-synthetic-opioids-ah-7921-and-mt-45
#6
Helena Fels, Julia Krueger, Hans Sachs, Frank Musshoff, Matthias Graw, Gabriele Roider, Andreas Stoever
In this study, two fatalities associated with the synthetic opioids AH-7921 and MT-45 are reported. Within the last few years, both compounds have emerged on the recreational drug market and are sold as "research chemicals" on the internet. In the first case, a 22-year-old woman was found dead in the bedroom of her apartment by two of her friends. A plastic bag labeled "AH-7921" was found in the apartment and the two friends stated that the deceased had consumed AH-7921 prior to her death. The woman was a known drug addict...
April 15, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28505371/the-arm-domain-of-armadillo-repeat-kinesin-1-is-not-required-for-microtubule-catastrophe-but-can-negatively-regulate-nima-related-kinase-6-in-arabidopsis-thaliana
#7
Ryan C Eng, Laryssa S Halat, Samuel J Livingston, Tatsuya Sakai, Hiroyasu Motose, Geoffrey Wasteneys
Microtubules are dynamic filaments, the assembly and disassembly of which are under precise control of various associated proteins, including motor proteins and regulatory enzymes. In Arabidopsis thaliana, two such proteins are the ARMADILLO-REPEAT KINESIN 1 (ARK1), which promotes microtubule disassembly, and the NIMA-RELATED KINASE 6 (NEK6), which has a role in organizing microtubule arrays. Previous yeast 2-hybrid and in vitro pull-down assays determined that NEK6 can interact with ARK1 through the latter protein's Armadillo-repeat (ARM) cargo domain...
May 13, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/28504468/incubatory-environment-of-the-scalp-impacts-pre-emergent-hair-to-affect-post-emergent-hair-cuticle-integrity
#8
James R Schwartz, James P Henry, Kathy M Kerr, Michael J Flagler, Steve H Page, Nancy Redman-Furey
OBJECTIVES: To determine whether the oxidative stress transmitted to newly grown hair from an unhealthy scalp has physical consequences to the cuticular condition and function. METHODS: A uniquely designed 24-week clinical study included 8 weeks of pretreatment with a cosmetic shampoo and 16 weeks of treatment with either a potentiated zinc pyrithione (ZPT) antidandruff shampoo or a placebo cosmetic shampoo. This clinical design allowed the growth and acquisition of hair samples under conditions of varying but known scalp health as a result of treating a dandruff/seborrheic dermatitis (D/SD) population...
May 14, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28502801/genome-wide-association-reveals-pigmentation-genes-play-a-role-in-skin-aging
#9
Matthew H Law, Sarah E Medland, Gu Zhu, Seyhan Yazar, Ana Viñuela, Leanne Wallace, Sri Niranjan Shekar, David L Duffy, Veronique Bataille, Dan Glass, Tim D Spector, Diane Wood, Scott D Gordon, Julie M Barbour, Anjali K Henders, Alex W Hewitt, Grant W Montgomery, Richard A Sturm, David A Mackey, Adèle C Green, Nicholas G Martin, Stuart MacGregor
Loss of fine skin patterning is a sign of both aging and photoaging. Studies investigating the genetic contribution to skin patterning offer an opportunity to better understand a trait that influences both physical appearance and risk of keratinocyte skin cancer. We undertook a meta-analysis of genome-wide association studies (GWAS) of a measure of skin pattern (microtopography score) damage in 1,671 twin pairs and 1,745 singletons (N = 5,087) drawn from three independent cohorts. We identified that rs185146 near SLC45A2 is associated with a skin aging trait (p = 4...
May 11, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28495198/phenotypic-expression-of-parasite-susceptibility-to-haemonchus-contortus-in-pelibuey-sheep
#10
N F Ojeda-Robertos, J F J Torres-Acosta, R González-Garduño, D R Notter
The objective of this study was to determine if the mean faecal egg count (FEC) from a first experimental Haemonchus contortus infection could be used to classify parasite-naïve Pelibuey hair sheep as parasite-resistant high responders and parasite-susceptible low responders. Twenty 6- to 7-month-old Pelibuey male sheep raised free of gastrointestinal nematodes were challenged with 7500±1412 H. contortus L3 larvae administrated orally on day 0 of the study. Faecal samples from each lamb were obtained daily from 21 to 41days post-infection (Stage I)...
May 30, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28494584/development-of-a-common-procedure-for-the-determination-of-methylmercury-ethylmercury-and-inorganic-mercury-in-human-whole-blood-hair-and-urine-by-triple-spike-species-specific-isotope-dilution-mass-spectrometry
#11
Silvia Queipo Abad, Pablo Rodriguez-Gonzalez, W Clay Davis, Jose Ignacio Garcia-Alonso
We report the first common methodology for the simultaneous determination of methylmercury (MeHg), ethylmercury (EtHg) and inorganic mercury (Hg(II)) in human blood hair and urine. With the exception of the initial sample mass (0.15 g for blood, 0.5 g for urine and 0.1 g for hair), the same sample preparation and GC-ICP-MS measurement conditions are employed for the three matrices providing experimental values in agreement with the certified values in the analysis of NIST SRM 955c (Caprine blood) Level 3 and the certified human hairs IAEA 085 and IAEA 086...
May 12, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28494168/uveal-melanoma-risk-factors-a-systematic-review-of-meta-analyses
#12
Taylor Nayman, Cristina Bostan, Patrick Logan, Miguel N Burnier
PURPOSE: There is currently no clinical risk-assessment tool allowing identification of patients at risk for developing uveal melanoma (UM) who might benefit from regular screening. As a first step toward the elaboration of such a tool, we systematically reviewed UM risk factors already established by meta-analysis. METHODS: Two reviewers independently screened Pubmed, Medline, Embase, and Web of Science from their respective inception dates until July 2016 using a combination of keywords and MeSH terms...
May 11, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28492437/continuous-intrathecal-infusion-of-cannabinoid-receptor-agonists-attenuates-nerve-ligation-induced-pain-in-rats
#13
Sheng-Jie Shiue, Hsien-Yu Peng, Chung-Ren Lin, Shih-Wei Wang, Ruey-Horng Rau, Jen-Kun Cheng
BACKGROUND AND OBJECTIVES: Cannabinoid receptors (CB1R/CB2R) are known to play important roles in pain transmission. In this study, we investigated the effects of continuous intrathecal infusion of CB1/2R agonists in the L5/6 spinal nerve ligation pain model. METHODS: Under isoflurane anesthesia, rats received nerve ligation and intrathecal catheter connected to an infusion pump. After surgery, saline (1 μL/h), CB1/2R agonist WIN55,212-2, CB1R agonist ACEA, or CB2R agonist AM1241 (1 μmol/h) was given intrathecally for 7 days...
May 10, 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/28491023/characterization-of-the-transcriptomes-of-lgr5-hair-cell-progenitors-and-lgr5-supporting-cells-in-the-mouse-cochlea
#14
Cheng Cheng, Luo Guo, Ling Lu, Xiaochen Xu, ShaSha Zhang, Junyan Gao, Muhammad Waqas, Chengwen Zhu, Yan Chen, Xiaoli Zhang, Chuanying Xuan, Xia Gao, Mingliang Tang, Fangyi Chen, Haibo Shi, Huawei Li, Renjie Chai
Cochlear supporting cells (SCs) have been shown to be a promising resource for hair cell (HC) regeneration in the neonatal mouse cochlea. Previous studies have reported that Lgr5+ SCs can regenerate HCs both in vitro and in vivo and thus are considered to be inner ear progenitor cells. Lgr5+ progenitors are able to regenerate more HCs than Lgr5- SCs, and it is important to understand the mechanism behind the proliferation and HC regeneration of these progenitors. Here, we isolated Lgr5+ progenitors and Lgr5- SCs from Lgr5-EGFP-CreERT2/Sox2-CreERT2/Rosa26-tdTomato mice via flow cytometry...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28490049/comparison-of-plasma-saliva-and-hair-levetiracetam-concentrations
#15
Katarzyna Karaś-Ruszczyk, Julita Kuczyńska, Halina Sienkiewicz-Jarosz, Iwona Kurkowska-Jastrzębska, Przemyslaw Bienkowski, Magdalena Restel, Jerzy Samochowiec, Pawel Mierzejewski
BACKGROUND: Previous findings revealed high correlations between serum/plasma and saliva levetiracetam concentrations, indicating saliva as an alternative matrix for monitoring levetiracetam therapy. Levetiracetam concentration in the hair, which could reflect long-term drug exposure and patients' compliance, has not been systematically tested, as yet. The aim of this study was to determine the correlation between plasma, saliva, and hair levetiracetam concentrations in 47 patients with epilepsy...
June 2017: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/28483257/protective-role-of-intratympanic-nigella-sativa-oil-against-gentamicin-induced-hearing-loss
#16
Deniz Tuna Edizer, Ozgur Yigit, Zehra Cinar, Mehmet Gul, Eyyup Kara, Birgul Yigitcan, Duygu Hayır, Ahmet Atas
OBJECTIVE: Aminoglycosides, used to combat with life-threatening infections, have a substantial risk of hearing loss. Nigella sativa is an annual herbaceous plant and used for treatment of many diseases for ages. We aimed to investigate the protective role of intratympanic nigella sativa oil against gentamicin induced hearing loss in an animal model. METHODS AND MATERIALS: Twenty eight guinea pigs were randomly divided into four groups: i-control, ii- Intratympanic nigella sativa oil (IT-NSO), iii- Intraperitoneal gentamicin (IP-G) and iv- Intraperitoneal gentamicin and intratympanic nigella sativa oil (IP-G + IT-NSO)...
June 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28480941/-zinc-concentrations-in-different-sample-media-from-dairy-cows-and-establishment-of-reference-values
#17
Laura Pieper, Fabian Schmidt, Anja-Elvira Müller, Rudolf Staufenbiel
OBJECTIVE: Zinc plays an important role in many body functions, including health and fertility. The assessment of the zinc supply can be performed using blood, urine and hair. The objective of this study was to establish reference values for herd analysis for the different sample media and stages of lactation in German dairy herds. MATERIALS AND METHODS: The data of 1515 herds, which had been visited by the Clinic for Ruminant and Swine, Free University of Berlin, Germany, between 1995 and 2012 were analyzed...
May 8, 2017: Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere
https://www.readbyqxmd.com/read/28480402/effect-of-ruanganjiedu-decoction-inhibit-experimental-hepatic-fibrosis-of-rats
#18
Sheng Liu, Xiao-Min Wang, Guo-Wang Yang
BACKGROUND: RuanGanJieDu (RGJD) is a traditional Chinese medicine comprising nine Chinese medicinal herbs. The clinical use of RGJD by us was found that it has a good control effect on hepatic fibrosis (HF) patient. In order to further investigate the Anti-fibrosis mechanism of RGJD, hence this experiment has been carried out. METHODS: After treatment, the general conditions of rats in each group were observed. The liver tissues morphology and HF phases were observed under light microscope...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28475227/re-evaluation-of-the-hydrogen-stable-isotopic-composition-of-keratin-calibration-standards-for-wildlife-and-forensic-science-applications
#19
David X Soto, Geoff Koehler, Leonard I Wassenaar, Keith A Hobson
RATIONALE: Determination of non-exchangeable hydrogen isotopic compositions (δ(2) H values) of bulk complex organic materials is difficult due to uncontrolled H isotope exchange between the organic material and ambient water vapor. A number of calibration keratinous materials with carefully measured hydrogen isotopic compositions of the non-exchangeable fraction were proposed to enable stable isotope laboratories to normalize their (2) H measurements. However, it was recently reported that high temperature carbon-reactor methods for measuring the hydrogen isotopic composition of nitrogenous organic materials is biased by the production of HCN in the reactor...
May 5, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28470871/survival-of-staphylococcus-pseudintermedius-in-modified-romanowsky-staining-solutions
#20
Angus Misan, Wei Yee Chan, Darren Trott, Peter B Hill
BACKGROUND: Stains that are used regularly for patient-side diagnosis to rapidly identify bacterial and fungal infections could become contaminated by common pathogens, such as Staphylococcus pseudintermedius, during slide immersion. HYPOTHESIS/OBJECTIVES: To determine whether the inoculation of S. pseudintermedius into modified Romanowsky type stains (Quick Dip(®) ) results in viable bacterial contamination and whether this is influenced by the addition of organic debris (canine hair and skin)...
May 3, 2017: Veterinary Dermatology
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