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Myxedema

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https://www.readbyqxmd.com/read/28396755/diagnosis-of-myxedema-coma-complicated-by-renal-failure-a-case-report
#1
Akiteru Takamura, Ryusho Sangen, Yoshiki Furumura, Daisuke Usuda, Yuji Kasamaki, Tsugiyasu Kanda
Myxedema coma, caused by severe lack of thyroid hormone, is characterized by deterioration of mental status, hypothermia, hypotension, hyponatremia, and hypoventilation. We describe an 84-year-old woman who presented with renal failure and new onset severe hypothyroidism leading to challenges in the recognition of myxedema coma.
April 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28355140/pretibial-myxedema-masquerading-as-a-venous-leg-ulcer
#2
Ingrid Herskovitz, Olivia Hughes, Flor MacQuhae, Robert S Kirsner
The authors report a case of pretibial myxedema (PTM) masquerading as a venous leg ulcer to alert wound care clinicians to this diagnostic possibility. Pretibial myxedema is a localized form of mucin cutaneous deposition characterized by indurated plaques most commonly on anterior legs. It is more likely to present in patients with Graves' disease, but it can be found in euthyroid patients as well. The physiopathology of PTM is complex, and there is an accumulation of highly hydrophilic glycosaminoglycans in the dermis...
March 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28255471/intracerebral-bleeding-and-massive-pericardial-effusion-as-presenting-symptoms-of-myxedema-crisis
#3
M Kirsch, C Rimpau, C H Nickel, P Baier
The endocrinological emergency of a fully blown myxedema crisis can present as a multicolored clinical picture. This can obscure the underlying pathology and easily lead to mistakes in clinical diagnosis, work-up, and treatment. We present a case of an unconscious 39-year-old patient with a medical history of weakness, lethargy, and findings of hyponatremia, intracerebral bleeding, and massive pericardial effusion. Finally, myxedema crisis was diagnosed as underlying cause. Replacement therapy of thyroid hormone and conservative management of the intracerebral bleeding resulted in patient's survival without significant neurological impairment...
2017: Case Reports in Emergency Medicine
https://www.readbyqxmd.com/read/28239466/nivolumab-induced-myxedema-crisis
#4
Uqba Khan, Humaira Rizvi, Dahlia Sano, Jane Chiu, Tarik Hadid
BACKGROUND: Nivolumab is an anti-programmed cell death (anti-PD-1) monoclonal antibody that is approved by Food and Drug Administration for treatment of metastatic non-small cell lung cancer, metastatic melanoma, relapsed Hodgkin lymphoma and advanced renal cell cancer. We report a rare case of myxedema crisis induced by nivolumab in a patient with metastatic squamous cell carcinoma of lung. CASE PRESENTATION: Fifty three-year old woman with metastatic squamous cell carcinoma currently on treatment with nivolumab presented with diffuse facial and tongue swelling, slurred speech, depressed mentation, fatigue and weakness...
2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28142035/clinical-characteristics-and-outcomes-of-myxedema-coma-analysis-of-a-national-inpatient-database-in-japan
#5
Yosuke Ono, Sachiko Ono, Hideo Yasunaga, Hiroki Matsui, Kiyohide Fushimi, Yuji Tanaka
BACKGROUND: Myxedema coma is a life-threatening and emergency presentation of hypothyroidism. However, the clinical features and outcomes of this condition have been poorly defined because of its rarity. METHODS: We conducted a retrospective observational study of patients diagnosed with myxedema coma from July 2010 through March 2013 using a national inpatient database in Japan. We investigated characteristics, comorbidities, treatments, and in-hospital mortality of patients with myxedema coma...
March 2017: Journal of Epidemiology
https://www.readbyqxmd.com/read/28055088/myxedema-psychosis-in-a-patient-with-undiagnosed-hashimoto-thyroiditis
#6
Matthew M Mavroson, Nirav Patel, Eleonora Akker
Myxedema psychosis is uncommon in patients with primary hypothyroidism. Most often, this disease state can be found in patients with Hashimoto thyroiditis or after total thyroidectomy. Chronic hypothyroidism can lead to an insidious onset of psychiatric symptoms in patients, such as dementia, delirium, psychosis, hallucinations, and coma. A 31-year-old man with an unremarkable medical history was brought to the psychiatric emergency department for new-onset aggression, paranoid behavior, and hallucinations for 4 days...
January 1, 2017: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/27872766/an-atypical-case-of-myxedema-coma-with-concomitant-nonconvulsive-seizure
#7
Pratik Patel, Mikhael Bekkerman, Cristina Varallo-Rodriguez, Rajendra Rampersaud
Hypothyroidism is a prevalent condition in the general population that is treatable with appropriately dosed thyroid hormone replacement medication. Infrequently, patients will present with myxedema coma, characterized by hypothermia, hypotension, bradycardia, and altered mental status in the setting of severe hypothyroidism. Myxedema coma has also been known to manifest in a number of unusual and dangerous forms. Here, we present the case of a woman we diagnosed with an uncharacteristic expression of myxedema coma and nonconvulsive seizure complicated by a right middle cerebral artery infarct...
2016: Case Reports in Critical Care
https://www.readbyqxmd.com/read/27851317/1682-mechanical-circulatory-support-in-myxedema-induced-cardiovascular-collapse
#8
Randi Connor-Schuler
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27823924/impending-myxedema-coma-as-the-initial-presentation-of-lung-cancer
#9
Chia-I Shen, Hsu-Ching Huang, Yi-Chen Yeh, Chao-Hua Chiu
No abstract text is available yet for this article.
November 4, 2016: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/27802562/periorbital-myxedema
#10
Jimmy Tam Huy, Christopher Thomas Doig
No abstract text is available yet for this article.
November 1, 2016: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/27730666/pre-tibial-mixedema-a-case-report-with-scanning-electron-microscopy
#11
R R da Cunha Filho, H L de Almeida, J D Basei, R H Camina, L A S de Castro
Pretibial myxedema (PTM) results from the accumulation of hyaluronic acid in the dermis and subcutis and is commonly associated with Graves' disease (GD). It occurs in up to 5% of patients with GD and in 13% of patients with GD and ophthalmopathy. PTM occasionally occurs in thyrotoxicosis but is much less frequently in patients with Hashimoto thyroiditis, primary hypothyroidism and euthyroidism. This article is protected by copyright. All rights reserved.
October 12, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27648339/morphological-diversity-of-pretibial-myxedema-and-its-mechanism-of-evolving-process-and-outcome-a-retrospective-study-of-216-cases
#12
Changgui Lan, Yi Wang, Xia Zeng, Jing Zhao, Xiaoxi Zou
Background. Pretibial myxedema (PTM) is a rare dermopathy. The morphologic features and mechanism of its evolving process are not reported in large case series. Methods. 216 cases with PTM were retrospectively reviewed to analyze demographics, history, lesional morphology and its evolving process, histopathology and immunohistochemistry, serum TRAb levels, treatment, and outcome. Results. First appearing lesions evolved into 6 variants that were correlated with serum TRAb levels. Subvariants were caused by different kinds and frequencies of local trauma...
2016: Journal of Thyroid Research
https://www.readbyqxmd.com/read/27631398/myxedema-coma-secondary-to-central-hypothyroidism-a-rare-but-real-cause-of-altered-mental-status-in-pediatrics
#13
Michael D Thompson, Rohan K Henry
BACKGROUND: Myxedema coma (MC), a medical emergency defined as severe hypothyroidism leading to altered mental status, is more common in older women with hypothyroidism. METHODS/RESULTS: A 7-year-old Caucasian male with chromosome 1q deletion presented with altered mental status preceded by milestone regression. His presenting labs results were: thyroid-stimulating hormone (TSH) 0.501 μIU/ml and free thyroxine (T4) <0.5 ng/dl. His morning cortisol level was 8...
September 16, 2016: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/27598067/thyroid-emergencies
#14
Angela M Leung
Myxedema coma and thyroid storm are thyroid emergencies associated with increased mortality. Prompt recognition of these states-which represent the severe, life-threatening conditions of extremely reduced or elevated circulating thyroid hormone concentrations, respectively-is necessary to initiate treatment. Management of myxedema coma and thyroid storm requires both medical and supportive therapies and should be treated in an intensive care unit setting.
September 2016: Journal of Infusion Nursing: the Official Publication of the Infusion Nurses Society
https://www.readbyqxmd.com/read/27583414/morbidity-and-mortality-risks-of-premature-enteral-nutrition-during-the-recovery-of-myxedema-coma-a-response-to-the-article-entitled-pediatric-patient-with-altered-mental-status-and-hypoxemia
#15
https://www.readbyqxmd.com/read/27504447/injected-hyaluronidase-reduces-the-volume-of-exogenous-hyaluronate-fillers-in-mice-and-results-in-clinical-improvement-in-a-patient-with-pretibial-myxedema
#16
Sébastien Menzinger, Aysin Kaya, Jean-Hilaire Saurat, Gürkan Kaya
BACKGROUND: Hyaluronidases are essential for the breakdown of hyaluronate (HA) in tissues and may be used to prevent the adverse effects of HA fillers. OBJECTIVES: We explored the effect of hyaluronidase on exogenous and endogenous HA in vitro and in vivo. MATERIALS AND METHODS: HA fillers were incubated with different concentrations of hyaluronidase and visualized by electrophoresis. HA fillers were injected in the skin of hairless mice, and 4 h later hyaluronidase was injected in the papules of exogenous HA...
July 2016: Dermatopathology (Basel, Switzerland)
https://www.readbyqxmd.com/read/27484454/management-of-endocrine-disease-hypothyroidism-associated-hyponatremia-mechanisms-implications-and-treatment
#17
REVIEW
G Liamis, T D Filippatos, A Liontos, M S Elisaf
BACKGROUND: Patients with moderate to severe hypothyroidism and mainly patients with myxedema may exhibit reduced sodium levels (<135 mmol/L). SUMMARY: The aim of this short review is the presentation of the mechanisms of hyponatremia and of the available data regarding its implications and treatment in patients with hypothyroidism. Hypothyroidism is one of the causes of hyponatremia, thus thyroid-stimulating hormone determination is mandatory during the evaluation of patients with reduced serum sodium levels...
January 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/27467035/-psychotic-episode-due-to-hashimoto-s-thyroiditis
#18
M Nazou, E Parlapani, E-I Nazlidou, P Athanasis, V P Bozikas
Thyroid hormones are crucial in adult brain metabolic activity. As a result, abnormal thyroid gland function and in particular hypofunction, might cause principally depression and neurocognitive dysfunction. Psychosis, presented mainly with thought disorders and perceptual disturbances, is a much rarer manifestation of hypothyreoidism. A correlation between hypothyreoidism and psychosis has been described since 1888, especially in cases of advanced hypothyreoidism. A few years later (1949), Asher first added the terminology "myxedema madness" to the literature...
April 2016: Psychiatrikē, Psychiatriki
https://www.readbyqxmd.com/read/27293919/levothyroxine-tablet-malabsorption-associated-with-gastroparesis-corrected-with-gelatin-capsule-formulation
#19
David P Reardon, Peter S Yoo
Treatment of hypothyroidism with levothyroxine sodium often requires multiple dose adjustments and can be complicated by patients with gastric and intestinal dysfunction that limits absorption. In these cases, doses are often titrated higher than commonly used in clinical practice. Multiple formulations of levothyroxine are currently available and some may be preferred in cases of malabsorption. We report a case of a 42-year-old female who presented with a living unrelated kidney transplant evaluation with myxedema while being treated with levothyroxine sodium tablets...
2016: Case Reports in Endocrinology
https://www.readbyqxmd.com/read/27106615/undiagnosed-hypothyroidism-presenting-with-sigmoid-volvulus
#20
Vadim Meytes, Steven P Schulberg, Nicholas Morin, Galina Glinik
The incidence of hypothyroidism presenting with sigmoid volvulus, a phenomenon known as myxedema pseudovolvulus, is exceedingly rare. A male in his late thirties presented to our institution with a chief complaint of abdominal pain. The patient underwent CT scan, which was consistent with massive colonic dilatation with sigmoid volvulus. He was taken to the operating room for exploration and was found to have sigmoid volvulus and underwent a segmental resection. Postoperatively, the patient was newly diagnosed with severe hypothyroidism...
2016: Journal of Surgical Case Reports
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