Javier D Martin-Romera, Emilio Borrego-Marin, Pedro J Jabalera-Ortiz, Francesco Carraro, Paolo Falcaro, Elisa Barea, Francisco J Carmona, Jorge A R Navarro
Organophosphate (OP) toxicity is related to inhibition of acetylcholinesterase (AChE) activity, which plays a key role in the neurotransmission process. In this work, we report the ability of different zinc zeolitic imidazolate frameworks (ZIFs) to behave as potential antidotes against OP poisoning. The Zn-L coordination bond (L = purine, benzimidazole, imidazole, or 2-methylimidazole) is sensitive to the G-type nerve agent model compounds diisopropylfluorophosphate (DIFP) and diisopropylchlorophosphate, leading to P-X (X = F or Cl) bond breakdown into nontoxic diisopropylphosphate...
February 12, 2024: ACS Applied Materials & Interfaces