Virginia Smit, Jill de Mol, Frank H Schaftenaar, Marie A C Depuydt, Rimke J Postel, Diede Smeets, Fenne W M Verheijen, Laurens Bogers, Janine van Duijn, Robin A F Verwilligen, Hendrika W Grievink, Mireia N A Bernabé Kleijn, Eva van Ingen, Maaike J M de Jong, Lauren Goncalves, Judith A H M Peeters, Harm J Smeets, Anouk Wezel, Julia K Polansky, Menno P J de Winther, Christoph J Binder, Dimitrios Tsiantoulas, Ilze Bot, Johan Kuiper, Amanda C Foks
AIMS: Aging is a dominant driver of atherosclerosis and induces a series of immunological alterations, called immunosenescence. Given the demographic shift towards elderly, elucidating the unknown impact of aging on the immunological landscape in atherosclerosis is highly relevant. While the young Western diet-fed Ldlr-deficient (Ldlr-/-) mouse is a widely used model to study atherosclerosis, it does not reflect the gradual plaque progression in the context of an aging immune system as occurs in humans...
June 30, 2023: Cardiovascular Research