keyword
https://read.qxmd.com/read/38419293/contribution-of-zinc-accumulation-to-ischemic-brain-injury-and-its-mechanisms-about-oxidative-stress-inflammation-and-autophagy-an-update
#21
JOURNAL ARTICLE
Xueqi Yang, Wei Li, Mao Ding, Ke Jian Liu, Zhifeng Qi, Yongmei Zhao
Ischemic stroke is a leading cause of death and disability worldwide, and presently, there is no effective neuroprotective therapy. Zinc is an essential trace element which plays important physiological roles in the central nervous system. Free zinc concentration is tightly regulated by zinc-related proteins in the brain under normal conditions. Disruption of zinc homeostasis, however, has been found to play an important role in the mechanism of brain injury following ischemic stroke. A large of free zinc releases from storage sites after cerebral ischemia, which affects the functions and survival of nerve cells, including neurons, astrocytes and microglia, resulting in cell death...
February 28, 2024: Metallomics: Integrated Biometal Science
https://read.qxmd.com/read/38407220/protection-of-ndrg2-deficiency-on-renal-ischemia-reperfusion-injury-via-activating-pink1-parkin-mediated-mitophagy
#22
JOURNAL ARTICLE
Min Liu, Jianwen Chen, Miao Sun, Lixia Zhang, Yao Yu, Weidong Mi, Yulong Ma, Guyan Wang
BACKGROUND: Renal ischemia-reperfusion (R-I/R) injury is the most prevalent cause of acute kidney injury, with high mortality and poor prognosis. However, the underlying pathological mechanisms are not yet fully understood. Therefore, this study aimed to investigate the role of N-myc downstream-regulated gene 2 (Ndrg2) in R-I/R injury. METHODS: We examined the expression of Ndrg2 in the kidney under normal physiological conditions and after R-I/R injury by immunofluorescence staining, real-time polymerase chain reaction, and western blotting...
February 26, 2024: Chinese Medical Journal
https://read.qxmd.com/read/38403042/bmsc-exosomes-attenuate-alp-dysfunction-by-restoring-lysosomal-function-via-the-mtor-tfeb-axis-to-reduce-cerebral-ischemia-reperfusion-injury
#23
JOURNAL ARTICLE
Haining Liu, Chen Li, Xiaofeng Zhang, Hui Chen, Qi Zhang, Yuting Zeng, Shuqi Zheng, Jihua Zou, Yijin Zhao, Xiaoyan Zheng, Guozhi Huang, Qing Zeng
BACKGROUND: The complex pathophysiological changes following cerebral ischemia-reperfusion injury (CIRI) include the accumulation of defective proteins and damaged organelles, which cause massive neuron demise. To preserve cellular homeostasis, the autophagy-lysosomal pathway (ALP) is crucial for neurons to dispose of these substances. Many studies have shown that bone mesenchymal stem cell exosomes (BMSC-Exos) can reduce CIRI. However, the specific mechanisms have not been well elucidated, a fact that limits its widespread clinical use...
February 23, 2024: Experimental Neurology
https://read.qxmd.com/read/38397792/the-activation-of-gaba-a-r-alleviated-cerebral-ischemic-injury-via-the-suppression-of-oxidative-stress-autophagy-and-apoptosis-pathways
#24
JOURNAL ARTICLE
Jing Lan, Jiaqi Wang, Shujing Wang, Jia Wang, Sijuan Huang, Yazhou Wang, Yunfei Ma
Ischemic stroke is a devastating disease leading to neurologic impairment. Compounding the issue is the very limited array of available interventions. The activation of a γ-aminobutyric acid (GABA) type A receptor (GABAA R) has been reported to produce neuroprotective properties during cerebral ischemia, but its mechanism of action is not yet fully understood. Here, in a rat model of photochemically induced cerebral ischemia, we found that muscimol, a GABAA R agonist, modulated GABAergic signaling, ameliorated anxiety-like behaviors, and attenuated neuronal damage in rats suffering cerebral ischemia...
February 3, 2024: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/38396999/the-sphingolipid-modulating-drug-opaganib-protects-against-radiation-induced-lung-inflammation-and-fibrosis-potential-uses-as-a-medical-countermeasure-and-in-cancer-radiotherapy
#25
JOURNAL ARTICLE
Lynn W Maines, Staci N Keller, Ryan A Smith, Cecelia L Green, Charles D Smith
Fibrosis is a chronic pathology resulting from excessive deposition of extracellular matrix components that leads to the loss of tissue function. Pulmonary fibrosis can follow a variety of diverse insults including ischemia, respiratory infection, or exposure to ionizing radiation. Consequently, treatments that attenuate the development of debilitating fibrosis are in desperate need across a range of conditions. Sphingolipid metabolism is a critical regulator of cell proliferation, apoptosis, autophagy, and pathologic inflammation, processes that are all involved in fibrosis...
February 15, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38395121/activation-of-adenosine-a2b-receptor-alleviates-myocardial-ischemia-reperfusion-injury-by-inhibiting-endoplasmic-reticulum-stress-and-restoring-autophagy-flux
#26
JOURNAL ARTICLE
Feng He, Fuyu Wang, Hanmin Xiang, Yunna Ma, Qing Lu, Yun Xia, Huimin Zhou, Yanlin Wang, Jianjuan Ke
Myocardial ischemia-reperfusion injury (MIRI) poses a significant threat to patients with coronary heart disease. Adenosine A2A receptors have been known as a protective role in MIRI by regulating autophagy, so we assumed that activation of adenosine A2B receptor (A2BAR) might exert a similar effect during MIRI and underlying mechanism be related to proteostasis maintenance as well. In situ hearts were subjected to 30 min of ischemia and 120 min of reperfusion (IR), while in vitro cardiomyocytes from neonatal rats experienced 6 h of oxygen-glucose deprivation followed by 12 h of reoxygenation (OGDR)...
February 21, 2024: Archives of Biochemistry and Biophysics
https://read.qxmd.com/read/38381297/transcription-factor-tfap2b-exerts-neuroprotective-effects-targeting-bnip3-mediated-mitophagy-in-ischemia-reperfusion-injury
#27
JOURNAL ARTICLE
Yong Peng, Jiaoying Jia, Mingming Zhang, Wenjia Ma, Yan Cui, Mengqiang Yu
Cerebral ischemia-reperfusion injury (CIRI) leads to malignant brain edema, blood-brain barrier destruction, and neuronal apoptosis. N6-methyladenosine (m6A) RNA modification in CIRI was still limited explored. In this study, MeRIP- and RNA-sequencing were performed of middle cerebral artery occlusion and reperfusion (MCAO/R) rats to find novel potential molecular targets. Transcription factor TFAP2B stood out of which its m6A abundance decreased associated with a marked reduction of its mRNA based on cojoint interactive bioinformatics analysis of the MeRIP- and RNA-sequencing data...
February 21, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38375039/systematic-review-of-melatonin-in-cerebral-ischemia-reperfusion-injury-critical-role-and-therapeutic-opportunities
#28
REVIEW
Chenguang Zhang, Yumei Ma, Yating Zhao, Na Guo, Chen Han, Qian Wu, Changqing Mu, Yue Zhang, Shutong Tan, Jian Zhang, Xu Liu
Cerebral ischemia-reperfusion (I/R) injury is the predominant causes for the poor prognosis of ischemic stroke patients after reperfusion therapy. Currently, potent therapeutic interventions for cerebral I/R injury are still very limited. Melatonin, an endogenous hormone, was found to be valid in preventing I/R injury in a variety of organs. However, a systematic review covering all neuroprotective effects of melatonin in cerebral I/R injury has not been reported yet. Thus, we perform a comprehensive overview of the influence of melatonin on cerebral I/R injury by collecting all available literature exploring the latent effect of melatonin on cerebral I/R injury as well as ischemic stroke...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38361405/autophagy-inhibitors-3-ma-and-baf-may-attenuate-hippocampal-neuronal-necroptosis-after-global-cerebral-ischemia-reperfusion-injury-in-male-rats-by-inhibiting-the-interaction-of-the-rip3-aif-cypa-complex
#29
JOURNAL ARTICLE
Chen Zhang, Renhui Liu, Mengmeng Chen, Yang Xu, Xiaoqin Jin, Bing Shen, Jingye Wang
Our previous study found that receptor interacting protein 3 (RIP3) and apoptosis-inducing factor (AIF) were involved in neuronal programmed necrosis during global cerebral ischemia-reperfusion (I/R) injury. Here, we further studied its downstream mechanisms and the role of the autophagy inhibitors 3-methyladenine (3-MA) and bafilomycin A1 (BAF). A 20-min global cerebral I/R injury model was constructed using the 4-vessel occlusion (4-VO) method in male rats. 3-MA and BAF were injected into the lateral ventricle 1 h before ischemia...
February 2024: Journal of Neuroscience Research
https://read.qxmd.com/read/38342329/h-2-s-alleviates-renal-ischemia-and-reperfusion-injury-by-suppressing-ers-induced-autophagy
#30
JOURNAL ARTICLE
Sujuan Feng, Jiawei Ji, Han Li, Xiaodong Zhang
BACKGROUND: Ischemia/reperfusion injury (IRI) can lead to acute kidney injury and result in high disability and mortality rates. Cystathionine γ-lyase (CSE)-produced hydrogen sulfide (H2 S) has been confirmed to play a protective role in renal IRI. While autophagy is involved in renal IRI, its role in the regulation by endoplasmic reticulum stress (ERS) has not been considered. Our study explored the role of CSE/H2 S in protecting against renal IRI by regulating ERS-induced autophagy...
February 9, 2024: Transplant Immunology
https://read.qxmd.com/read/38342018/roles-of-flavonoids-in-ischemic-heart-disease-cardioprotective-effects-and-mechanisms-against-myocardial-ischemia-and-reperfusion-injury
#31
JOURNAL ARTICLE
Hui Xu, Shenglong Yu, Chunxi Lin, Dingjun Dong, Jianbo Xiao, Yanbin Ye, Mingfu Wang
BACKGROUND: Flavonoids are extensively present in fruits, vegetables, grains, and medicinal plants. Myocardial ischemia and reperfusion (MI/R) comprise a sequence of detrimental incidents following myocardial ischemia. Research indicates that flavonoids have the potential to act as cardioprotective agents against MI/R injuries. Several specific flavonoids, e.g., luteolin, hesperidin, quercetin, kaempferol, and puerarin, have demonstrated cardioprotective activities in animal models. PURPOSE: The objective of this review is to identify the cardioprotective flavonoids, investigate their mechanisms of action, and explore their application in myocardial ischemia...
February 2, 2024: Phytomedicine
https://read.qxmd.com/read/38331229/tetrahydropiperine-a-natural-alkaloid-with-neuroprotective-effects-in-ischemic-stroke
#32
JOURNAL ARTICLE
Hongyan Ren, Qianqian Yuan, Jiayuan Lu, Siyu Xi, Yanbo Liu, Guangyu Yang, Zhixi Xie, Bo Wang, Li Ma, Xueyan Fu, Juan Liu, Yiwei Zhang
BACKGROUND: Ischemic stroke (IS) is a life-threatening neurological disease with various pathological mechanisms. Tetrahydropiperine (THP) is a natural alkaloid with protective effects against multiple diseases, such as seizure, and pain. This study was to examine the impact of THP on IS and investigate its potential mechanism. MATERIAL AND METHODS: We employed network pharmacology and molecular docking techniques to identify the target proteins of THP for intervention in IS...
February 6, 2024: Journal of Chemical Neuroanatomy
https://read.qxmd.com/read/38331005/effects-of-h-2-s-donor-ascorbic-acid-derivative-and-ischemia-reperfusion-induced-injury-in-isolated-rat-hearts
#33
JOURNAL ARTICLE
Bence Tánczos, Virág Vass, Erzsébet Szabó, Miklós Lovas, Rasha Ghanem Kattoub, Ilona Bereczki, Anikó Borbás, Pál Herczegh, Árpád Tósaki
Hydrogen sulfide (H2 S), a gasotransmitter, plays a crucial role in vasorelaxation, anti-inflammatory processes and mitigating myocardial ischemia/reperfusion-induced injury by regulating various signaling processes. We designed a water soluble H2 S-releasing ascorbic acid derivative, BM-164, to combine the beneficial cardiovascular and anti-inflammatory effects of H2 S with the excellent water solubility and antioxidant properties of ascorbic acid. DPPH antioxidant assay revealed that the antioxidant activity of BM-164 in the presence of a myocardial tissue homogenate (extract) increased continuously over the 120 min test interval due to the continuous release of H2 S from BM-164...
February 6, 2024: European Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/38328828/berberine-alleviates-ischemic-brain-injury-by-enhancing-autophagic-flux-via-facilitation-of-tfeb-nuclear-translocation
#34
JOURNAL ARTICLE
Yi-Li Liu, Tao Guo, Yong-Jie Zhang, Shun-Cong Tang, Xiao-Ming Zhao, Hong-Yun He, Chun-Lei Yu, Yi-Hao Deng
Berberine has been demonstrated to alleviate cerebral ischemia/reperfusion injury, but its neuroprotective mechanism has yet to be understood. Studies have indicated that ischemic neuronal damage was frequently driven by autophagic/lysosomal dysfunction, which could be restored by boosting transcription factor EB (TFEB) nuclear translocation. Therefore, this study investigated the pharmacological effects of berberine on TFEB-regulated autophagic/lysosomal signaling in neurons after cerebral stroke. A rat model of ischemic stroke and a neuronal ischemia model in HT22 cells were prepared using middle cerebral artery occlusion (MCAO) and oxygen-glucose deprivation (OGD), respectively...
February 7, 2024: American Journal of Chinese Medicine
https://read.qxmd.com/read/38325526/protective-effects-and-mechanisms-of-dapagliflozin-on-renal-ischemia-reperfusion-injury
#35
JOURNAL ARTICLE
Qiuxiao-Zhu, Huiyao-Hao, Na Li, Zibo-Liu, Qian-Wang, Linyi-Shu, Lihui-Zhang
BACKGROUND: Renal diseases have a significant negative impact on human health and the quality of life. Renal ischemia/reperfusion (I/R) injury is considered as one of the leading causes of renal dysfunction and tissue damage. Oxidative stress and inflammation are responsible for cellular apoptosis playing critical roles in renal I/R injury. Recent studies suggested that dapagliflozin-a medication used to treat Type 2 Diabetes-may exert protective effects on I/R injury in kidneys by alleviating oxidative stress and inflammation...
February 5, 2024: Transplant Immunology
https://read.qxmd.com/read/38311344/angiotensin-1-7-increases-cardiac-tolerance-to-ischemia-reperfusion-and-mitigates-adverse-remodeling-of-the-heart-the-signaling-mechanism
#36
REVIEW
Ivan A Derkachev, Sergey V Popov, Leonid N Maslov, Alexandr V Mukhomedzyanov, Natalia V Naryzhnaya, Alexander S Gorbunov, Artur Kan, Andrey V Krylatov, Yuri K Podoksenov, Ivan V Stepanov, Svetlana V Gusakova, Feng Fu, Jian-Ming Pei
BACKGROUND: The high mortality rate of patients with acute myocardial infarction (AMI) remains the most pressing issue of modern cardiology. Over the past 10 years, there has been no significant reduction in mortality among patients with AMI. It is quite obvious that there is an urgent need to develop fundamentally new drugs for the treatment of AMI. Angiotensin 1-7 has some promise in this regard. OBJECTIVE: The objective of this article is analysis of published data on the cardioprotective properties of angiotensin 1-7...
February 4, 2024: Fundamental & Clinical Pharmacology
https://read.qxmd.com/read/38310454/effects-and-mechanisms-of-fisetin-against-ischemia-reperfusion-injuries-a-systematic-review
#37
JOURNAL ARTICLE
Omid-Ali Adeli, Saeid Heidari-Soureshjani, Sahar Rostamian, Zahra Azadegan-Dehkordi, Armin Khaghani
BACKGROUND: Ischemia-reperfusion injury (IRI) is a well-known ailment that can disturb organ function. OBJECTIVES: This systematic review study investigated fisetin's effects and possible mechanisms in attenuating myocardial, cerebral, renal, and hepatic IRIs. METHODS: This systematic review included studies earlier than Sep 2023 by following the PRISMA statement 2020. After determining inclusion and exclusion criteria and related keywords, bibliographic databases, such as Cochrane Library, PubMed, Web of Science, Embase, and Scopus databases, were used to search the relevant studies...
January 28, 2024: Current Pharmaceutical Biotechnology
https://read.qxmd.com/read/38301300/suxiao-jiuxin-pill-alleviates-myocardial-ischemia-reperfusion-induced-autophagy-via-mir-193a-3p-alkbh5-pathway
#38
JOURNAL ARTICLE
Dongyuan Wang, Dan Wang, Qipeng Jin, Xiaolong Wang
BACKGROUND: Myocardial ischemia/reperfusion injury (MIRI) poses a formidable challenge to cardiac reperfusion therapy due to the absence of effective clinical interventions. Methylation of N6-methyladenosine (m6 A), which is the most common post-transcriptional modifications occurring within mammalian mRNA, is believed to be involved in MIRI by modulating autophagy. MicroRNAs (miRNAs) play a crucial role in regulating gene expression at the post-transcriptional level and have been implicated in the regulation of m6 A methylation...
January 24, 2024: Phytomedicine
https://read.qxmd.com/read/38299288/inhibition-of-taurine-upregulated-gene-1-upregulates-mir-34a-5p-to-protect-against-myocardial-ischemia-reperfusion-via-autophagy-regulation
#39
JOURNAL ARTICLE
Qunjun Duan, Aiqiang Dong, Haifeng Cheng, Shufen Zhang, Wei Chen, Weijun Yang
BACKGROUND: Taurine upregulated gene 1 (TUG1) has been identified on long noncoding RNA (lncRNA); however, its function in myocardial cells following ischemia/ reperfusion (I/R) injury has not been explored. This study aimed to investigate the role of LncTUG1 in I/R injury by focusing on its relationship with autophagy induction by regulating miR-34a-5p expression. METHODS: We established a myocardial I/R model and H9C2 hypoxia-ischemic and reoxygenation (HI/R) conditions to induce I/R injury...
January 30, 2024: Combinatorial Chemistry & High Throughput Screening
https://read.qxmd.com/read/38299238/-retracted-antagonist-targeting-mir%C3%A2-106b%C3%A2-5p-attenuates-acute-renal-injury-by-regulating-renal-function-apoptosis-and-autophagy-via-the-upregulation-of-tcf4
#40
Jing-Meng Hu, Li-Jie He, Peng-Bo Wang, Yan Yu, Ya-Ping Ye, Li Liang
Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that the EdU staining assay data shown in Figs. 4C and 5C and the western blotting data shown in Fig. 4E were strikingly similar to data appearing in different form in other research articles written by different authors at different research institutes that had either already been published, or were submitted for publication at around the same time. Owing to the fact that contentious data in the above article had already been submitted for publication elsewhere prior to its submission to International Journal of Molecular Medicine , the Editor has decided that this paper should be retracted from the Journal...
March 2024: International Journal of Molecular Medicine
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