Renjie Hu, Wenjun Fan, Sanduo Li, Guoqing Zhang, Lu Zang, Li Qin, Ran Li, Rucheng Chen, Lu Zhang, Weijia Gu, Yunhui Zhang, Sanjay Rajagopalan, Qinghua Sun, Cuiqing Liu
Airborne fine particulate matter (PM2.5 ) exposure is closely associated with metabolic disturbance, in which brown adipose tissue (BAT) is one of the main contributing organs. However, knowledge of the phenotype and mechanism of PM2.5 exposure-impaired BAT is quite limited. In the study, male C57BL/6 mice at three different life phases (young, adult, and middle-aged) were simultaneously exposed to concentrated ambient PM2.5 or filtered air for 8 weeks using a whole-body inhalational exposure system. H&E staining and high-resolution respirometry were used to assess the size of adipocytes and mitochondrial function...
May 4, 2024: Ecotoxicology and Environmental Safety