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https://www.readbyqxmd.com/read/28098956/the-effect-of-reference-group-classification-and-change-in-alcohol-consumption-on-the-association-between-alcohol-consumption-and-cardiovascular-disease
#1
Ji-Eun Park, Yeonhee Ryu, Sung-Il Cho
BACKGROUND: Many studies suggest that mild alcohol consumption can help avert cardiovascular disease (CVD). This study investigated the association between alcohol consumption and CVD incidence, and assessed whether this differed by reference group classification. As alcohol consumption amounts may change over time, the results of simple and time-dependent analyses were compared. METHODS: Data were from a community-based cohort study on 40- to 69-year-old Koreans recruited in 2001 to 2002...
January 18, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28098946/negative-association-between-mr-spectroscopic-glutamate-markers-and-gray-matter-volume-after-alcohol-withdrawal-in-the-hippocampus-a-translational-study-in-humans-and-rats
#2
Ulrich Frischknecht, Derik Hermann, Nuran Tunc-Skarka, Guo-Ying Wang, Markus Sack, Julia van Eijk, Traute Demirakca, Claudia Falfan-Melgoza, Bertram Krumm, Sandra Dieter, Rainer Spanagel, Falk Kiefer, Karl F Mann, Wolfgang H Sommer, Gabriele Ende, Wolfgang Weber-Fahr
BACKGROUND: Both chronic alcohol consumption and alcohol withdrawal lead to neural tissue damage which partly recovers during abstinence. This study investigated withdrawal-associated changes in glutamatergic compounds, markers of neuronal integrity, and gray matter volumes during acute alcohol withdrawal in the hippocampus, a key region in development and maintenance of alcohol dependence in humans and rats. METHODS: Alcohol-dependent patients (N = 39) underwent magnetic resonance imaging (MRI) and MR spectroscopy (MRS) measurements within 24 hours after the last drink and after 2 weeks of abstinence...
January 18, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28098917/tanning-equipment-use-2014-canadian-community-health-survey
#3
Sami Q Qutob, Michelle O'Brien, Katya Feder, James McNamee, Mireille Guay, John Than
BACKGROUND: Tanning equipment use is related to the early onset of cancer, with the risk increasing as the duration and repetition of exposure increase. In 2009, the International Agency for Research on Cancer classified tanning equipment use as carcinogenic to humans, and according to the World Health Organization, the risk of skin melanoma increases significantly when use begins before age 35. DATA AND METHODS: The rapid response component of the 2014 Canadian Community Health Survey collected data on the use of tanning equipment in the previous 12 months, including reasons for use, frequency/duration of use, precautions taken, and adverse reactions or injuries...
January 18, 2017: Health Reports
https://www.readbyqxmd.com/read/28098898/a-hepatic-stem-cell-vaccine-is-superior-to-an-embryonic-stem-cell-vaccine-in-the-prophylaxis-and-treatment-of-murine-hepatocarcinoma
#4
Qi Zheng, Yichao Zheng, Jing Chen, Jia You, Yueyong Zhu, Yurui Liu, Jia Ji Jiang
Stem cells and cancer cells express a common subset of antigens called oncofetal antigens. Theoretically, vaccination with stem cells is effective at boosting the preexisting anticancer immune response. Herein we describe the efficacy of two stem cell-based vaccines in the prophylaxis and treatment of subcutaneous hepatic tumors transplanted into mice. C57BL/6j mice were vaccinated weekly with either hepatic stem cells (HSCs) or embryonic stem cells (ESCs) for three weeks, followed by a subcutaneous challenge with Hepa 1-6 cells at one week (group 1) or four weeks (group 2) after vaccination...
January 17, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28098869/core%C3%A2-shell-lipid-polymer-nanoparticles-for-combined-chemo%C3%A2-and-gene-therapy-of-childhood-head-and-neck-cancers
#5
Tiesong Zhang, Jing Ma, Chao Li, Ken Lin, Fan Lou, Hongchao Jiang, Yingqin Gao, Yanli Yang, Cheng Ming, Biao Ruan
Pediatric head and neck cancers account for overall 12% of all pediatric cancers. Despite recent advances in therapeutic modalities, children with tumor metastasis have poor prognosis. Therefore, there is an unmet need for new and effective treatment modalities for pediatric head and neck cancers. The present study describes a simple and efficient method for fabrication of cationic lipid‑polymer hybrid nanoparticles (CLPNs) for co‑delivery of cisplatin (CDDP) and DNA (CDDP/DNA CLPNs) for the therapy of childhood head and neck cancers...
January 13, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28098858/mir-345-inhibits-tumor-metastasis-and-emt-by-targeting-irf1-mediated-mtor-stat3-akt-pathway-in-hepatocellular-carcinoma
#6
Miao Yu, Huanzhou Xue, Yadong Wang, Quan Shen, Qingfeng Jiang, Xiao Zhang, Ke Li, Meng Jia, Jiangkun Jia, Jian Xu, Yuwei Tian
MicroRNAs (miRNAs) have been reported to play critical roles in tumor progression including hepatocellular carcinoma (HCC). Thus, the underlying mechanisms need further investigation. Previous study reported that loss of miR-345 expression indicated a poor prognosis of HCC patients. This study evaluated whether loss of miR-345 could promote the tumor metastasis and epithelial-mesenchymal-transition (EMT) of HCC by targeting interferon regulatory factor 1 (IRF1)-mediated mTOR/STAT3/AKT signaling. Underexpression of miR-345 was identified in 65 cases of human HCC compared to matched tumor-adjacent tissues by qRT-PCR...
January 17, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28098857/anticancer-effects-of-ginsenoside-rg3-review
#7
Mengyao Sun, Ying Ye, Ling Xiao, Xinya Duan, Yongming Zhang, Hong Zhang
Cancer is a life-threatening disease with an alarmingly increased annual mortality rate globally. Although various therapies are employed for cancer, the final effect is not satisfactory. Chemotherapy is currently the most commonly used treatment option. However, the unsatisfactory efficacy, severe side-effects and drug resistance hinder the therapeutic efficacy of chemotherapeutic drugs. There is increasing evidence indicating that ginsenoside Rg3, a naturally occurring phytochemical, plays an important role in the prevention and treatment of cancer...
January 13, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28098839/continuous-glucose-monitoring-enables-the-detection-of-losses-in-infusion-set-actuation-lisas
#8
Daniel P Howsmon, Faye Cameron, Nihat Baysal, Trang T Ly, Gregory P Forlenza, David M Maahs, Bruce A Buckingham, Juergen Hahn, B Wayne Bequette
Reliable continuous glucose monitoring (CGM) enables a variety of advanced technology for the treatment of type 1 diabetes. In addition to artificial pancreas algorithms that use CGM to automate continuous subcutaneous insulin infusion (CSII), CGM can also inform fault detection algorithms that alert patients to problems in CGM or CSII. Losses in infusion set actuation (LISAs) can adversely affect clinical outcomes, resulting in hyperglycemia due to impaired insulin delivery. Prolonged hyperglycemia may lead to diabetic ketoacidosis-a serious metabolic complication in type 1 diabetes...
January 15, 2017: Sensors
https://www.readbyqxmd.com/read/28098825/optical-fibre-sensors-using-graphene-based-materials-a-review
#9
REVIEW
Miguel Hernaez, Carlos R Zamarreño, Sonia Melendi-Espina, Liam R Bird, Andrew G Mayes, Francisco J Arregui
Graphene and its derivatives have become the most explored materials since Novoselov and Geim (Nobel Prize winners for Physics in 2010) achieved its isolation in 2004. The exceptional properties of graphene have attracted the attention of the scientific community from different research fields, generating high impact not only in scientific journals, but also in general-interest newspapers. Optical fibre sensing is one of the many fields that can benefit from the use of these new materials, combining the amazing morphological, chemical, optical and electrical features of graphene with the advantages that optical fibre offers over other sensing strategies...
January 14, 2017: Sensors
https://www.readbyqxmd.com/read/28098816/estrogen-enhances-the-expression-of-the-multidrug-transporter-gene-abcg2-increasing-drug-resistance-of-breast-cancer-cells-through-estrogen-receptors
#10
Fung-Wei Chang, Hueng-Chuen Fan, Jui-Ming Liu, Tai-Ping Fan, Jin Jing, Chia-Ling Yang, Ren-Jun Hsu
BACKGROUND: Multidrug resistance is a major obstacle in the successful therapy of breast cancer. Studies have proved that this kind of drug resistance happens in both human cancers and cultured cancer cell lines. Understanding the molecular mechanisms of drug resistance is important for the reasonable design and use of new treatment strategies to effectively confront cancers. RESULTS: In our study, ATP-binding cassette sub-family G member 2 (ABCG2), adenosine triphosphate (ATP) synthase and cytochrome c oxidase subunit VIc (COX6C) were over-expressed more in the MCF-7/MX cell line than in the normal MCF7 cell line...
January 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28098813/reverse-vaccinology-an-approach-for-identifying-leptospiral-vaccine-candidates
#11
REVIEW
Odir A Dellagostin, André A Grassmann, Caroline Rizzi, Rodrigo A Schuch, Sérgio Jorge, Thais L Oliveira, Alan J A McBride, Daiane D Hartwig
Leptospirosis is a major public health problem with an incidence of over one million human cases each year. It is a globally distributed, zoonotic disease and is associated with significant economic losses in farm animals. Leptospirosis is caused by pathogenic Leptospira spp. that can infect a wide range of domestic and wild animals. Given the inability to control the cycle of transmission among animals and humans, there is an urgent demand for a new vaccine. Inactivated whole-cell vaccines (bacterins) are routinely used in livestock and domestic animals, however, protection is serovar-restricted and short-term only...
January 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28098791/development-of-high-throughput-method-for-measurement-of-vascular-nitric-oxide-generation-in-microplate-reader
#12
Soad S Abd El-Hay, Christa L Colyer
BACKGROUND: Despite the importance of nitric oxide (NO) in vascular physiology and pathology, a high-throughput method for the quantification of its vascular generation is lacking. OBJECTIVE: By using the fluorescent probe 4-amino-5-methylamino-2',7'-difluorofluorescein (DAF-FM), we have optimized a simple method for the determination of the generation of endothelial nitric oxide in a microplate format. METHODS: A nitric oxide donor was used (3-morpholinosydnonimine hydrochloride, SIN-1)...
January 13, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28098788/evaluation-of-potential-average-daily-doses-adds-of-pm2-5-for-homemakers-conducting-pan-frying-inside-ordinary-homes-under-four-ventilation-conditions
#13
Seonyeop Lee, Sol Yu, Sungroul Kim
Several studies reported that commercial barbecue restaurants likely contribute to the indoor emission of particulate matters with a diameter of 2.5 micrometers or less (PM2.5) while pan-frying meat. However, there is inadequate knowledge of exposure level to indoor PM2.5 in homes and the contribution of a typical indoor pan-frying event. We measured the indoor PM2.5 concentration and, using Monte-Carlo simulation, estimated potential average daily dose (ADD) of PM2.5 for homemakers pan-frying a piece of pork inside ordinary homes...
January 13, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28098734/multimodal-fundus-imaging-of-outer-retinal-tubulations-in-choroidal-osteoma-patients
#14
Yi Xuan, Yongjin Zhang, Min Wang, Jinli Guo, Lei Li, Wei Liu, Xiaofeng Ye
PURPOSE: To evaluate the morphological findings of outer retinal tubulations (ORTs) shown on multimodal imaging modalities in patients with choroidal osteoma. METHODS: Nineteen eyes of 17 patients with choroidal osteoma underwent full clinical and imaging assessments. Color fundus photography, spectral-domain optical coherence tomography (OCT), and en face OCT were used to identify and detect the characteristics of ORT structures, including the shape, configuration, location, and distribution in the fundus...
January 16, 2017: Retina
https://www.readbyqxmd.com/read/28098732/significant-reduction-of-peripapillary-choroidal-thickness-in-patients-with-unilateral-branch-retinal-vein-occlusion
#15
Hae Min Kang, Jeong Hoon Choi, Hyoung Jun Koh, Christopher Seungkyu Lee, Sung Chul Lee
PURPOSE: To evaluate changes in peripapillary choroidal thickness in patients with branch retinal vein occlusion (BRVO) over 12 months, using spectral-domain optical coherence tomography with enhanced depth imaging. METHODS: This retrospective, interventional case series included 20 treatment-naive patients with unilateral BRVO with at least 12 months follow-up. The peripapillary choroidal thickness was measured over 12 months. RESULTS: In BRVO-affected eyes, the mean peripapillary choroidal thickness was 213...
January 16, 2017: Retina
https://www.readbyqxmd.com/read/28098718/double-exposure-to-adverse-psychosocial-work-factors-and-high-family-responsibilities-as-related-to-ambulatory-blood-pressure-at-work-a-5-year-prospective-study-in-women-with-white-collar-jobs
#16
Mahée Gilbert-Ouimet, Chantal Brisson, Alain Milot, Michel Vézina
OBJECTIVE: Accumulating evidence shows that psychosocial work factors of the demand-control and effort-reward imbalance models may contribute to increase blood pressure (BP). Women are more likely to be exposed to these psychosocial factors than men. Moreover, women spend twice as much time per week performing family responsibilities than men. This study aims to evaluate the longitudinal association of the double exposure to psychosocial work factors and high family responsibilities in women with BP over a 5-year follow-up...
January 17, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28098706/current-trends-in-ulnar-collateral-ligament-reconstruction-surgery-among-newly-trained-orthopaedic-surgeons
#17
Ryan M Degen, Christopher L Camp, Johnathan A Bernard, David M Dines, David W Altchek, Joshua S Dines
INTRODUCTION: Ulnar collateral ligament (UCL) reconstructions are being performed with an increasing annual incidence. The purpose of this study was to evaluate trends in UCL surgery among recently trained orthopaedic surgeons. METHODS: The American Board of Orthopaedic Surgeons (ABOS) database was used to identify all UCL reconstructions from 2004 to 2013. Procedures were identified by Current Procedural Terminology (CPT) codes and verified by International Classification of Disease, Ninth Revision (ICD-9) codes...
February 2017: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/28098705/heterotopic-ossification-in-acetabular-fracture-surgery
#18
Reza Firoozabadi, Timothy Alton, Henry Claude Sagi
Heterotopic ossification (HO) is a common complication of the surgical treatment of acetabular fractures. HO is the formation of trabecular bone in soft tissues where bone does not usually occur. Over the last decade, many risk factors have been identified for HO after surgical fixation of acetabular fractures; however, prophylaxis and treatment of this condition are controversial. Potential preventive measures range from NSAIDs to external beam irradiation, but recent studies have questioned the utility of these measures...
February 2017: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/28098672/a-chronicle-of-pa-journals
#19
Roderick S Hooker
At its semicentennial mark, the PA profession appears to be flourishing. Over the past 50 years, a number of journals have emerged to highlight the development of the profession and offer observations on it. The Physician Associate Journal, launched in 1970, was the first foray into PA reporting. Following this small effort, a dozen journals or newspapers came into print, lasted for a while, and then were replaced or died. Of journals that survived to the present, four are in English and one in Dutch. Three of the five journals are association-based, and four produce clinical articles; publication is monthly, quarterly, or semiannually...
February 2017: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/28098667/18f-naf-pet-ct-in-symptomatic-fabella-syndrome
#20
Sharjeel Usmani, Fahad Marafi, Najeeb Ahmed, Fareeda Al Kandari
Fabella is a sesamoid bone, located within the tendon of the lateral head of the gastrocnemius muscle. It may be associated with posterolateral knee pain because of repetitive friction over the posterolateral femoral condyle. We report a case of a 64-year-old woman presenting with right posterolateral knee pain. F-NaF PET-CT demonstrated increased uptake posterior to the right knee joint localizing to a fabella. Standard examination and radiographic imaging excluded other causes for posterolateral knee pain, and the increased activity was considered to be secondary to fabella syndrome...
January 16, 2017: Clinical Nuclear Medicine
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