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https://www.readbyqxmd.com/read/28441841/-an-experiment-control-study-on-the-ovarian-reserve-function-after-cisplatin-intraperitoneal-or-intravenous-chemotherapy-in-rats-model
#1
B Z Fan, H Xia, L Chu, X W Tong
Objective: To compare the impact on the ovarian reserve function after cisplatin intraperitoneal or intravenous chemotherapy in rats model. Methods: Thirty 8-weeks old female Sprague Dawley rats were randomly assigned to control group (group A, n=10), intraperitoneal chemotherapy group (group B, n=10) and intravenous chemotherapy group (group C, n=10). Cisplatin was diluted by normal saline (NS) into 4 mg/ml. On the first day of chemotherapy, 0.2 ml cisplatin dilution was injected into the abdomen of rats in group B, isodose cisplatin was injected into vein and 1...
April 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/28441797/breast-cancer-awareness-among-women-in-western-amazon-a-population-based-cross-sectional-study
#2
Marla Presa Raulino Schilling, Ilce Ferreira da Silva, Simone Perufo Opitz, Maria Fernanda de Sousa Oliveira Borges, Sergio Koifman, Koifman Rosalina Jorge
Background: A general lack of women`s awareness of breast cancer has been one of the barriers to screening and early presentation. Thus, the aim of this study was to evaluate levels of knowledge about risk factors, and early warning signs of breast cancer, and to determine factors associated with better levels of comprehension. Methods: A population-based cross-sectional study was carried out among 478 women over 40 years old, living in Rio Branco city, western Amazon. All were interviewed using the “Breast cancer knowledge, attitudes and practice scale”, developed by American Cancer Society...
March 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28441781/dengue-virus-non-structural-protein-5
#3
REVIEW
Abbas El Sahili, Julien Lescar
The World Health Organization estimates that the yearly number of dengue cases averages 390 million. This mosquito-borne virus disease is endemic in over 100 countries and will probably continue spreading, given the observed trend in global warming. So far, there is no antiviral drug available against dengue, but a vaccine has been recently marketed. Dengue virus also serves as a prototype for the study of other pathogenic flaviviruses that are emerging, like West Nile virus and Zika virus. Upon viral entry into the host cell and fusion of the viral lipid membrane with the endosomal membrane, the viral RNA is released and expressed as a polyprotein, that is then matured into three structural and seven non-structural (NS) proteins...
April 24, 2017: Viruses
https://www.readbyqxmd.com/read/28441777/health-effects-of-psidium-guajava-l-leaves-an-overview-of-the-last-decade
#4
REVIEW
Elixabet Díaz-de-Cerio, Vito Verardo, Ana María Gómez-Caravaca, Alberto Fernández-Gutiérrez, Antonio Segura-Carretero
Today, there is increasing interest in discovering new bioactive compounds derived from ethnomedicine. Preparations of guava (Psidium guajava L.) leaves have traditionally been used to manage several diseases. The pharmacological research in vitro as well as in vivo has been widely used to demonstrate the potential of the extracts from the leaves for the co-treatment of different ailments with high prevalence worldwide, upholding the traditional medicine in cases such as diabetes mellitus, cardiovascular diseases, cancer, and parasitic infections...
April 24, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28441770/direction-of-arrival-estimation-for-mimo-radar-via-unitary-nuclear-norm-minimization
#5
Xianpeng Wang, Mengxing Huang, Xiaoqin Wu, Guoan Bi
In this paper, we consider the direction of arrival (DOA) estimation issue of noncircular (NC) source in multiple-input multiple-output (MIMO) radar and propose a novel unitary nuclear norm minimization (UNNM) algorithm. In the proposed method, the noncircular properties of signals are used to double the virtual array aperture, and the real-valued data are obtained by utilizing unitary transformation. Then a real-valued block sparse model is established based on a novel over-complete dictionary, and a UNNM algorithm is formulated for recovering the block-sparse matrix...
April 24, 2017: Sensors
https://www.readbyqxmd.com/read/28441748/convergent-validity-of-a-wearable-sensor-system-for-measuring-sub-task-performance-during-the-timed-up-and-go-test
#6
James Beyea, Chris A McGibbon, Andrew Sexton, Jeremy Noble, Colleen O'Connell
BACKGROUND: The timed-up-and-go test (TUG) is one of the most commonly used tests of physical function in clinical practice and for research outcomes. Inertial sensors have been used to parse the TUG test into its composite phases (rising, walking, turning, etc.), but have not validated this approach against an optoelectronic gold-standard, and to our knowledge no studies have published the minimal detectable change of these measurements. METHODS: Eleven adults performed the TUG three times each under normal and slow walking conditions, and 3 m and 5 m walking distances, in a 12-camera motion analysis laboratory...
April 23, 2017: Sensors
https://www.readbyqxmd.com/read/28441745/breast-cancer-screening-programmes-across-the-who-european-region-differences-among-countries-based-on-national-income-level
#7
Emma Altobelli, Leonardo Rapacchietta, Paolo Matteo Angeletti, Luca Barbante, Filippo Valerio Profeta, Roberto Fagnano
Breast cancer (BC) is the most frequent tumour affecting women all over the world. In low- and middle-income countries, where its incidence is expected to rise further, BC seems set to become a public health emergency. The aim of the present study is to provide a systematic review of current BC screening programmes in WHO European Region to identify possible patterns. Multiple correspondence analysis was performed to evaluate the association among: measures of occurrence; GNI level; type of BC screening programme; organization of public information and awareness campaigns regarding primary prevention of modifiable risk factors; type of BC screening services; year of screening institution; screening coverage and data quality...
April 23, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28441718/therapeutic-effect-of-melittin-on-a-rat-model-of-chronic-prostatitis-induced-by-complete-freund-s-adjuvant
#8
Li Lin, Bao-Ping Zhu, Liang Cai
OBJECTIVES: The present study was aimed to establish a model of chronic prostatitis in rat with the use of intraprostatic injection of Complete Freund's Adjuvant, and to examine the anti-inflammatory and analgesic effects of melittin on the newly-developed chronic prostatic pain model. METHODS: Adult male Sprague-Dawley rats were injected with Complete Freund's Adjuvant (CFA) into the prostate. Twelve days after model rats of the treatment group were injected melittin into the prostate, while those of the control group received sterile saline injection...
April 21, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28441700/ultrasound-based-renal-sympathetic-denervation-for-the-treatment-of-therapy-resistant-hypertension-a-single-center-experience
#9
Karl Fengler, Robert Höllriegel, Thomas Okon, Thomas Stiermaier, Karl-Philipp Rommel, Stephan Blazek, Christian Besler, Max von Roeder, Martin Petzold, Gerhard Schuler, Philipp Lurz
INTRODUCTION: The effectiveness of renal sympathetic denervation (RDN) as a treatment for therapy-resistant hypertension has been doubted as the Simplicity-HTN-3 trial was unable to show any treatment benefit over sham procedure. This might partly be explained by a high procedural variability in treatment with radiofrequency-based catheters. Recently, newer systems for RDN, like ultrasound-based devices, have been introduced into practice. To date however, data on their effectiveness for the treatment of resistant hypertension are scarce...
June 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28441699/folic-acid-therapy-reduces-the-risk-of-mortality-associated-with-heavy-proteinuria-among-hypertensive-patients
#10
Youbao Li, Xianhui Qin, Lian Luo, Binyan Wang, Yong Huo, Fan Fan Hou, Xin Xu
OBJECTIVE: We aimed to evaluate whether proteinuria and estimated glomerular filtration rate (eGFR) levels can modify the efficacy of folic acid therapy on the risk of all-cause mortality among hypertensive patients in the China Stroke Primary Prevention Trial, a randomized, double-blind, and controlled trial. METHODS: A total of 20 702 hypertensive patients without a history of major cardiovascular diseases were randomly assigned to a double-blind daily treatment of a single tablet containing 10-mg enalapril and 0...
June 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28441698/ambulatory-arterial-stiffness-index-and-its-role-in-assessing-arterial-stiffness-in-dialysis-patients
#11
Wenjin Liu, Jiajun Zhou, Jianping Chen, Meijuan Meng, Xiurong Li, Chaoqing Gao, Jianmei Zhou, Liang Wang, Zhuxing Sun, Hong Chu, Wei Fan, Youwei Bai, Junwei Yang
OBJECTIVE: Ambulatory arterial stiffness index (AASI) is a parameter derived from ambulatory blood pressure (ABP) readings. It is calculated as 1 minus the linear slope of DBP on SBP. We tested its value in assessing arterial stiffness in dialysis patients. METHODS: We performed a cross-sectional analysis of the baseline data from a cohort study. A total of 344 patients on maintenance hemodialysis from six tertiary hospitals were included. All patients underwent ABP monitoring and carotid-femoral pulse wave velocity (cfPWV) measurement...
June 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28441696/declining-blood-pressure-and-intensification-of-blood-pressure-management-among-people-over-80-years-cohort-study-using-electronic-health-records
#12
Rathi Ravindrarajah, Alex Dregan, Nisha C Hazra, Shota Hamada, Stephen H D Jackson, Martin C Gulliford
BACKGROUND: Management of high blood pressure (BP) in people over 80 years is controversial, but there is limited information available concerning the uptake of hypertension treatment at this age. OBJECTIVE: To evaluate use of antihypertensive drugs and changes in SBP and DBP from 2001 to 2014 in men and women aged 80 years and over. METHODS: Cohort study using primary care electronic health records of 265 225 participants from the UK Clinical Practice Research Datalink...
June 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28441677/building-a-global-online-community-of-practice-the-openpediatrics-world-shared-practices-video-series
#13
Traci A Wolbrink, Niranjan Kissoon, Nabila Mirza, Jeffrey P Burns
PROBLEM: Health care professionals are familiar with engaging in local communities of practice (CoPs) within their hospital, region, and/or country, but despite the availability of online technologies that facilitate online global collaboration, the health care sector has yet to fully embrace these tools. APPROACH: In 2013, OPENPediatrics (an online social learning platform) launched the World Shared Practices video (WSP) series to engage and coalesce the global community of critical care clinicians...
May 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28441673/gateways-to-the-laboratory-how-an-md-phd-program-increased-the-number-of-minority-physician-scientists
#14
Ruth Gotian, Jemella C Raymore, Shauna-Kay Rhooms, Laura Liberman, Olaf S Andersen
Traditional underrepresented minority (URM) groups (African Americans, Hispanic Americans, Native Americans) remain underrepresented among physician-scientists. To address the dearth of URM physician-scientists, in 1993 the Weill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-PhD Program developed a pipeline program, Gateways to the Laboratory (Gateways), which focuses on increasing the breadth and depth of the URM physician-scientist pipeline by offering an all-encompassing summer research training program which mirrors the life of a physician-scientist...
May 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28441652/ultraviolet-a1-phototherapy-in-the-treatment-of-early-mycosis-fungoides
#15
Esra Adışen, Volkan Tektaş, Funda Erduran, Özlem Erdem, Mehmet Ali Gürer
BACKGROUND: Phototherapy has been the mainstay of therapies for early mycosis fungoides (MF). The beneficial role of ultraviolet (UV) light on MF is suggested by the observation that lesions occur on non-sun-exposed areas. Therapeutic light sources that are available today are broadband UVB, psoralen and UVA, narrowband UVB, and long-wave UV (UVA1). Current literature provides increasing evidence on the use of UVA1 to treat MF. AIM: To investigate the treatment responses of early MF patients treated with fixed 30 J/cm2 doses of UVA1 phototherapy...
April 26, 2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/28441647/subjective-memory-in-a-national-sample-predicting-psychological-well-being
#16
Jacqueline A Mogle, Nikki Hill, Caroline McDermott
BACKGROUND: Individual perception of memory performance (i.e., subjective memory) is assessed using a variety of approaches. This article focuses on 2 such approaches: (1) self-comparison assessments that attempt to capture changes in memory ability over a period of time and (2) age-anchored comparisons that assess how an individual perceives their memory in relation to others their age. These different types of assessment may relate to psychological well-being differently due to the underlying mechanisms of assessment...
April 26, 2017: Gerontology
https://www.readbyqxmd.com/read/28441638/health-risk-assessment-for-the-consumption-of-fresh-and-preserved-fish-alosa-agone-from-lago-di-como-northern-italy
#17
Silvia Quadroni, Roberta Bettinetti
BACKGROUND: Although banned in many countries for decades, DDTs and PCBs still represent a global threat to food safety. As these contaminants are still present in aquatic ecosystems, fish can be an important contributor to their total dietary intake. OBJECTIVES: Alosa agone specimens were sampled over a period of 10 years (from 2006 to 2015) to provide a representative overview of the DDT and PCB levels of Lago di Como, a deep Italian lake where a DDT input due to secondary sources was observed in recent years...
April 22, 2017: Environmental Research
https://www.readbyqxmd.com/read/28441635/validation-of-smartrank-a-likelihood-ratio-software-for-searching-national-dna-databases-with-complex-dna-profiles
#18
Corina C G Benschop, Linda van de Merwe, Jeroen de Jong, Vanessa Vanvooren, Morgane Kempenaers, C P Kees van der Beek, Filippo Barni, Eusebio López Reyes, Léa Moulin, Laurent Pene, Hinda Haned, Titia Sijen
Searching a national DNA database with complex and incomplete profiles usually yields very large numbers of possible matches that can present many candidate suspects to be further investigated by the forensic scientist and/or police. Current practice in most forensic laboratories consists of ordering these 'hits' based on the number of matching alleles with the searched profile. Thus, candidate profiles that share the same number of matching alleles are not differentiated and due to the lack of other ranking criteria for the candidate list it may be difficult to discern a true match from the false positives or notice that all candidates are in fact false positives...
April 15, 2017: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/28441602/fluoride-and-iodine-enrichment-in-groundwater-of-north-china-plain-evidences-from-speciation-analysis-and-geochemical-modeling
#19
Junxia Li, Hailing Zhou, Kun Qian, Xianjun Xie, Xiaobin Xue, Yijun Yang, Yanxin Wang
To better understand the enrichment of fluoride and iodine in groundwater at North China Plain (NCP), speciation analysis and geochemical modeling were conducted to identify the key hydrochemical processes controlling their mobilization in groundwater system. Groundwater fluoride and iodine concentrations ranged from 0.18 to 5.59mg/L and from 1.51 to 1106μg/L, respectively, and approximately 63% and 32.3% of groundwater fluoride and iodine were higher than the guidelines for drinking water (1.5mg/L and 150μg/L)...
April 22, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28441595/modelling-drivers-and-distribution-of-lead-and-zinc-concentrations-in-soils-of-an-urban-catchment-sydney-estuary-australia
#20
L E Johnson, T F A Bishop, G F Birch
The human population is increasing globally and land use is changing to accommodate for this growth. Soils within urban areas require closer attention as the higher population density increases the chance of human exposure to urban contaminants. One such example of an urban area undergoing an increase in population density is Sydney, Australia. The city also possesses a notable history of intense industrial activity. By integrating multiple soil surveys and covariates into a linear mixed model, it was possible to determine the main drivers and map the distribution of lead and zinc concentrations within the Sydney estuary catchment...
April 22, 2017: Science of the Total Environment
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